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INTRODUCTION: The study aims as a pilot study to evaluate the effect of different treatment regimen and different types of endodontic sealers on pain and periapical radiographic changes was studied. MATERIALS AND METHODS: Forty patients in need of an endodontic root canal treatment on anterior teeth were selected and divided into two groups (20 patients each), according to the endodontic treatment protocol (single or multiple visits). Then, each group was subdivided into two subgroups according to sealer used 10 each (AH Plus Jet resin sealer, Total Fill Bioceramic Sealer). To record pain intensity of the patients at different intervals: 1, 2, 3, 7 days, a visual analog scale was used. Furthermore, patients were recalled after 1, 3, 6, 9 months to evaluate periapical radiographic changes. RESULTS: Showed that as regard pain assessment both tested endodontic sealers, as well as single or multiple visits have no statistically significant difference between pain values of patients during all the observation period from immediately post-operative, after 4, 12, 24, 48, 72 h as well as after 7 days (p > 0.05). As regard lamina dura thickness, results showed that with both tested endodontic sealers as well as single or multiple visits, there was no statistically significant difference between lamina dura thickness of patients after 1 month, 3, 6 as well as after 9 months. CONCLUSIONS: Neither number of visits of endodontic treatment nor type of sealer used for obturation affects post-operative pain and thickness of lamina dura.

Background Guinea pigs with dental disease usually present with nonspecific signs such as reduced food intake, difficulty eating and poor general condition. It is assumed that deficient dental attrition is the cause for overlong teeth. Giant teeth, or Macrodonts, have been mentioned as an occasionally occurring pathology. Methods Guinea pigs with clinically and radiologically confirmed dental disease presented between 2011 and 2014 and with complete sets of radiographs of the skull (laterolateral, dorsoventral, oblique and isolated views of the mandible and maxilla) were included in this retrospective study (n = 131). Every tooth was radiologically assessed and documented as changed, if an alteration in tooth width, tooth structure, periodontal ligament space, alveolar bone lamina dura and, in the incisors, pulp cavity was present. Special focus was placed on macrodonts and their additional alterations besides increase in width. Results The majority (89% = 116/131) of all guinea pigs had at least one macrodont; more than half (58% = 246/422) of all abnormal teeth were macrodonts. In total, 246 teeth (54 incisors, 192 cheek teeth) were diagnosed as macrodonts by means of radiography based on the presence of tooth expansion. Mandibular incisors were much more often affected by macrodontia (87%, 47/54). Furthermore, 91% (175/192) of cheek teeth macrodonts were found in the last two tooth positions. In the present study 97% of all macrodonts (238/246) showed both expansion and structural loss. Alterations to the periodontal ligament space were found in 76% (118/246) of macrodonts. The lamina dura of alveolar bone was changed in 46% (113/246) of cases. Abnormalities of the pulp cavity were present in 80% (43/54) of incisor macrodonts. Conclusion and clinical relevance In conclusion, macrodonts occur much more often than previously documented and present a common diagnostic finding in guinea pigs with dental disease. Macrodontia is radiologically characterised by expansion of the tooth and structural loss.

Objectives. The dental alveolus is lined by a thin cortical layer (“bundle bone”, “alveolar bone proper”, “cribriform plate”, “lamina dura”), that can impede access to the bone marrow and its vasculature. During unassisted socket healing, the alveolar bundle bone is gradually resorbed allowing tissue resources from the bone marrow to enter into the socket space. An optimized wound healing process, either during unassisted socket healing or during ridge preservation procedures, with autogenous bone and/or any bone/collagen substitute material, depends at least partly on an adequate vascularization of the socket space. This ensures sufficient recruitment of osteoblast and osteoclast precursor cells and facilitates fast bone regeneration and/or uneventful integration of the augmentation material. Methods. The present technical note describes an easy treatment step after tooth extraction aiming to improve socket healing with or without any ridge preservation procedure, by facilitating an increased blood inflow into the dental alveolus. Specifically, after tooth extraction the alveolar bundle bone is perforated several times – mainly in a palatally/lingually – by a small round bur (diameter < 1 mm) extending into the trabecular bone. Results and conclusions. By means of this relatively simple treatment step, an increased blood inflow into the alveolus is achieved after tooth extraction, which might enhance socket healing and corticalization of the entrance, and in turn result in a lower complication rate (e.g., dry socket), in an enhanced graft incorporation, and/or in a reduced loss of alveolar ridge volume.

Background Sagittal fractures of equine cheek teeth are commonly observed during oral examination. There are few reports on the apical and endodontic pathology associated with such fractures seen during computed tomographic (CT) examination. Objectives This study aimed to document the prevalence of CT changes indicative of apical disease in equine cheek teeth, which have suffered a sagittal fracture involving the clinical ± reserve crown. Study design This study is a retrospective case series. Methods CT examinations of equine heads with sagittal fractures of cheek teeth present were reviewed: 81 teeth from 49 horses were identified to have a sagittal cheek tooth fracture. The images were evaluated for apical pathology including gas (in the endodontic system and periapically), widened periodontal space, periapical sclerosis, apical clubbing, cementoma/hypercementosis, lamina dura loss, associated sinusitis and sinus mucosal swelling. An apical infection grading system was created to give each tooth a score. Hounsfield units were used to measure the density of the endodontic, apical and periapical regions. The fracture length ratio was recorded. Statistical analysis was performed using a generalised estimating equation to evaluate predictors of apical infection and associations between clinical signs and CT abnormalities. Results Eighty-seven sagittal fractures (56 buccal, 17 palatal/lingual and 14 midline) from 81 teeth were recorded (74 maxillary and 7 mandibular). Apical infection was diagnosed in 73% (37/51, P = .05) of buccal, 55% (6/11, P = .07) of palatal/lingual, 100% (13/13) of midline, 100% (6/6) of multiple fractures and 96% (23/24, P = .008) of fractures involving infundibula. There was no significant relationship between apical infection and the presence of clinical signs associated with dental pathology (P = .4). There was no significant association between fracture length ratio and apical infection (P = 1.0). Midline sagittal fractures were significantly associated with sinusitis when compared with all other maxillary fractures (odds ratio [OR] 5.92, 95% confidence interval [CI] 1.67-20.83, P = .006). Loss of the lamina dura was not significantly associated with apical infection (P = .5). Main limitations There is a maxillary cheek tooth bias in the data set and the subjective grading system. Conclusions A large proportion of fractured cheek teeth have evidence of apical infection on CT examination and therefore warrant treatment.

Dens invaginatus is a developmental deformation with varying anatomical features, caused by the envelopment of the enamel organ and/or the Hertwig’s epithelial root sheath within the tooth before calcification completes, increasing the vulnerability of pulpal and periodontal inflammation, posing challenges to treatment, and adequate healing. Cell rest of Malassez, remnants of enamel organ or root sheet may cause cystic lesion formations, also hinder the normal healing process and form a fibrous scar. Intraosseous fibrous scar is a result of incomplete wound healing after periradicular surgery which mimics an asymptomatic residual cyst clinically and radiographically. We herein report a case of a surgically managed an immature maxillary lateral incisor affected with Type II dens invaginatus associated with incomplete periradicular healing presented as intraosseous fibrous scar with a persistent well-defined radiolucency between the healthy trabecular bone. The regular clinical and radiographic follow-up records the asymptomatic endodontically treated dens invaginatus with an intact lamina dura and regular healing trabecular bone pattern. Its 4 years of post-operative evaluation has been presented. Features of this case, causes of such incomplete healing, diagnosis, treatment line, prognosis, and the dilemma of the clinician are discussed together with its probable implications.

Medication-related osteonecrosis of the jaws (MRONJ) is a rare and serious adverse effect of anti-resorptive and/or antiangiogenic therapy that can cause necrotic bone exposure in the oral cavity, which affects patients’ quality of life. The present study aimed to review literature regarding MRONJ with special focus on diagnostic and treatment. The databases PubMed, Scielo and Google Scholar were searched for reports regarding diagnostic and treatment of MRONJ. Even though this disorder shows poor response to treatment, there is an increase in cure rates when early diagnosed and treated. In this way, systematic dental follow-up of patients under anti-resorptive and/or antiangiogenic therapy is essential for the identification of signs and symptoms suggestive of MRONJ like pain, swelling or dental mobility. Radiographic and tomographic features like increase of bone density, bone sclerosis or osteolysis, persisting alveolar socket, periosteal neoformation, lamina dura widening and mandibular canal widening may indicate bone necrosis. Since there is no universally accepted treatment to cure MRONJ, the management involves symptom palliation and control of associated infection, and surgical excision of necrotic bone is recommended for more severe cases. Each case must be individually evaluated by a multidisciplinary team, allowing dental and medical discussion. The prevention of MRONJ by patients education, elimination of risk factors and oral health maintenance is still the most important measure in the management of these patients. A osteonecrose maxilar relacionada a medicamentos (MRONJ) é um raro e grave efeito adverso de terapia antirreabsortiva e/ou antiangiogênica que pode causar exposição de osso necrótico em cavidade bucal, o que implica na qualidade de vida dos pacientes. O presente trabalho teve por objetivo revisar a literatura sobre MRONJ enfatizando os critérios de diagnóstico e tratamento. As bases de dados PubMed, Scielo e Google scholar foram consultadas em busca de artigos que abordassem o tema. Embora apresente baixa resposta ao tratamento, o diagnóstico e tratamento precoce aumentam a chance de cura. Dessa forma, o acompanhamento odontológico sistemático de pacientes que estejam em terapia antirreabsortiva e/ou antiangiogênica é fundamental para a identificação de sinais ou sintomas sugestivos de MRONJ como dor, tumefação ou mobilidade dentária. Alterações radiográficas ou tomográficas como aumento da densidade óssea, esclerose óssea ou osteólise, persistência de alvéolo dentário, neoformação periosteal, espessamento da lâmina dura e estreitamento do canal mandibular podem ser indicativos da presença de necrose óssea. Como ainda não existe um tratamento universalmente aceito capaz de curar a MRONJ, a abordagem envolve paliação de sintomas e controle da infecção associada, reservando-se a remoção cirúrgica da área necrótica para casos mais graves. Salienta-se que cada caso deve ser avaliado individualmente por uma equipe multidisciplinar que permita a discussão entre a equipe de saúde bucal e equipe médica. A prevenção da MRONJ por meio da educação dos pacientes, eliminação dos fatores de risco e manutenção da saúde bucal constitui ainda a medida mais importante no manejo desses indivíduos.

Cribriform adenocarcinoma of minor salivary gland (CAMSG) is currently classified as a subtype of polymorphous adenocarcinoma. CAMSG differs from polymorphous adenocarcinoma in that it has a distinct histopathologic appearance and clinically CAMSG has higher rate of lymph node metastasis at initial presentation. Panoramic radiograph shows an ill-defined radiolucent lesion in the right maxilla that extends from the distal of maxillary right canine to the mesial of maxillary second molar. The lesion has invasive borders and causes destruction and loss of the lamina dura and periodontal ligament space in the mesial of the second molar and distal of the canine. The lesion has also invaded into the right maxillary sinus destroying the floor of sinus. CBCT images show a low attenuation lesion involving the right maxillary alveolar bone at the premolars and first molar area. This report describes the radiographic appearance of a case of CAMSG on panoramic radiograph, cone-beam computed tomography (CBCT), multi-detector computed tomography (MDCT) and on magnetic resonance imaging (MRI).

The central giant cell granuloma (CGCG) presents as a benign, painless, slow-growing swelling of the jaw. These lesions are reported more frequently in females and most often occur in the mandible. Radiographically, it presents as a distinct delineated bony pathology with a loss of lamina dura around teeth. There can be frequent signs of displacement of teeth and tooth germs. Currently, the usually followed surgical treatment of the CGCG ranges from simple curettage to en -bloc resection. The extensive resection of aggressive and larger lesions inevitably results in the loss of teeth and tooth germs, especially in younger patients. Since, calcitonin has a direct inhibiting effect on osteoclasts and is efficient in controlling diseases with increased osteoclast activity, such as Paget’s disease, and osteoclastic bone metastases, hence serve as a promising alternative. This paper presents the effectiveness and safety of Calcitonin nasal spray, in the management of a CGCG of the jaw, in an 8-year-old patient who was given calcitonin as first-line therapy. Keywords: Bony pathology, Calcitonin nasal spray, Central giant cell granuloma (CGCG), Enbloc resection, Management, Swellings of jaws.

Background/Purpose Due to the rarity of oral lymphoma (OL), we aimed to evaluate the clinical features of OL and discuss these findings in light of the literature. Methods English language literature (1980–2019) related to OL was searched in two electronic databases. Patients (2000–2019) diagnosed with OL were also selected from the database of the Oral Pathology Department in our institution. The clinical features, radiographic appearance, and histopathological diagnosis in these selected cases from publications and our institution were then analyzed. Results 607 cases of OL (15 in our institution and 592 from literature) in patients aged between 0 and 92 years (average, 51.8 years) with a male to female ratio of 1.6:1 were included. The most common diagnosis was diffuse large B-cell lymphoma (n = 205), followed by Burkitt lymphoma (n = 72) and T-cell lymphoma (n = 37). The most frequent site was the gingiva, followed by palate, maxilla, mandible, tongue and buccal mucosa. The most frequent symptoms were swelling, ulceration, paresthesia, mobile tooth and pain. Radiographic findings included ill-defined osteolytic lesion, thickening of the periodontal ligament, loss of lamina dura and tooth displacement. Conclusion Despite the rarity of extranodal lymphomas in oral cavity, their occurrence may be part of disseminated disease. Detailed history-taking, clinical and imaging examination and awareness of the patient's signs and symptoms are important for early diagnosis and an improved prognosis. The current data form a useful basis for clinical investigation and teaching regarding lymphoma occurring in the oral cavity.

Purpose To evaluate the success rate of simultaneous autotransplantation of the immature impacted third molars with the guidance of computer-aided rapid prototyping (CARP) to the place of mandibular first or second molars with extraction indication due to the untreatable radiographic periapical lesions. Patients and Methods Twelve radiographically and clinically hopeless mandibular first or second molars with periapical lesions of 10 patients between the ages of 15 to 21 were included in this retrospective clinical study. Cone-beam computed tomography (CBCT) images were used to produce the CARP models of the donor impacted third molars. Following the extractions of the mandibular first or second molars with periapical lesions, sockets were curetted and prepared with proper burs until a suitable infraocclusal fit of the CARP models. The donor teeth were transplanted synchronously with their surgical extractions. Postoperatively patients were followed clinically and radiographically in the 3rd and 6th months and every 6th month thereafter for at least 18 months. Clinically, the mobility, periodontal plaque, bleeding on probing, percussion sensitivity, periodontal pocket, vitality, and occlusion, and radiographically, the root resorption, ankylosis, presence of lamina dura, and healing of periapical lesion were assessed. Result By the end of 12th month, and thereafter, all transplanted teeth were in occlusion and functioning properly with no clinical or radiological signs of pathology. All of the autotransplantation cases involved in this clinical study were successful within a mean follow-up period of 20.4 months with the least one of 18 months. Conclusion Immediate autotransplantation of the immature third molars to the place of mandibular first or second molars with extraction indication due to the periapical lesion can be a proper treatment option for adolescent patients.

Objective: this study aims to assess the rate of agreement between panoramic radiography (PR) and CBCT in evaluating the radiographic features of intraosseous lesions and detecting whether these differences had a significant impact on the accuracy of differential diagnoses. Methods: Twenty four (24) intraosseous biopsy-proven lesions were reviewed using PR and CBCT images by two oral and maxillofacial radiologists. Both observers answered eighteen questions for each case describing the lesions` radiographic criteria and listed two possible differential diagnoses for each case. Results: McNemar’s test was used for comparing the two modalities and for calculating the inter-observer agreement. The intra-observer agreement showed that questions 18 (cortical destruction) and 10 (expansion in the anatomical landmarks) had the lowest percentage of agreement between both observers. Furthermore, there was no statistically significant difference between the two modalities in terms of the agreement between differential diagnosis and final diagnosis (P > 0.05). Conclusions: Both PR and CBCT provide similar agreement in describing the lesion location, epicenter, internal structure. Moreover, similar agreement was also observed regarding the effect of the lesion on the teeth including resorption, impaction and displacement, root resorption, lamina dura, and periodontal membrane space of the teeth. The main disagreement between the two modalities was found in the expansion of the normal surrounding anatomic boundaries, and cortical destruction.

The management of an immature permanent tooth protocol aims to eliminate pulpal pathology, disinfection, and if possible, redevelopment of the root. The paper aimed to present a case report that a successful survival history of a seemingly inadequate mineral trioxide aggregate plug and its 8-year follow-up. In the presented case, all treatment goals such as the elimination of clinical symptoms/signs of infection, apical periodontitis healing, healthy lamina dura, and further root maturation were achieved; however, a formation was observed in an 8-year recall similar to regeneration-associated intracanal calcification. There was no way to clinically understand how the healing process occurred in the area histologically, but the follow-up showed that the relevant tooth met the healing criteria.

Panoramic imaging is the most widely requested radiographic technique in dentistry. In orthodontics, the clinical and radiographic examinations are routinely carried out along with dental and skeletal photographs as a part of diagnosis and treatment planning. The evaluation of radiographs of patients after orthodontic treatment is important in understanding the possible changes that tend to occur post-treatment. This study aims to analyze the incidental findings present in the radiographs of patients who previously underwent orthodontic treatment. A total of 30 patients (18 females; 12 male) were randomly selected from the Orthodontic clinic at the Department of Orthodontics, Saveetha Dental College and Hospital, Chennai. Two independent examiners analyzed the panoramic radiographs for anomalies and pathologies. The result showed the most common finding, which was periodontal pathology (Generalised bone loss, widening of periodontal ligament space, or both, loss of lamina dura) with a prevalence of 36.7%. All the patients taken into the study had at least one anomaly. In conclusion, the relevant findings were observed in all the radiographs & special care should be taken while evaluating them to diagnose alterations that may require other dental treatments.

Periapical lesion is the most common sequelae of pulp necrosis due to either carious involvement or trauma. Treatment options to manage periapical lesion with open apex ranges from non-surgical root canal treatment and/or apical surgery to extraction. Objective: clinicall and radiogrphicall evaluation of the effect of MTA and bioceramic root canal sealer to manage immature permenant teeth with open apex. Methodology: The study was composed of sixty teeth from 54 children with age ranged from seven to ten years old age. Children were divided in to two equal groups: 1-Group A:Teeth were received apexification with MTA 2-Group B:Teeth were received apexification with bioceramic root canal sealer. All patients were followed clinically and radiographically immediate postoperatively, 3 and 6 months. Results: The success rate in both bioceramic and MTA was 93.3% and 90% respectively with no statistical significant difference. After 6 months, all teeth shows normal lamina dura among both bio ceramic and MTA groups. While, reduced radiolucences and obvious healing of bone detected among 93.3% and 90% of tooth among bio ceramic and MTA groups respectively. Conclusions: Both MTA and bioceramic sealer show good results

The main aim is to identify, by means of different imaging modalities, the early bone changes in patients “at risk” and in stage 0 MRONJ. A search of the literature was performed on PubMed, Embase, Web of Science, and Cochrane Library databases, until June 9, 2020. No language or year restrictions were applied. Screening of the articles, data collection, and qualitative analysis was done. The Newcastle-Ottawa Scale (NOS) was used for observational studies, and the Systematic Review Centre for Laboratory Animal Experimentation’s (SYRCLE) risk of bias tool for the animal studies. A total of 1188 articles were found, from which 47 were considered eligible, whereas 42 were suitable for the qualitative analysis. They correspond to 39 human studies and 8 animal studies. Radiographic findings such as bone sclerosis, osteolytic areas, thickening of lamina dura, persisting alveolar socket, periapical radiolucency, thicker mandibular cortex, widening of the periodontal ligament space, periodontal bone loss, and enhancement of the mandibular canal were identified as early bone changes due to antiresorptive therapy. All those findings were also reported later in Stage 0 patients. The main limitations of these results are the lack of prospective data and comparisons groups; therefore, careful interpretation should be made. It is a fact that radiographic findings are present in antiresorptive-treated patients, but the precise timepoint of occurrence, their relation to the posology, and potential risk to develop MRONJ are not clear. The importance of a baseline radiographic diagnosis for antiresorptive-treated patients.

Lateral periodontal cysts (LPCs) are odontogenic cysts with rare occurrence and developmental origin. A 46-year old female patient, chronic smoker with non-contributory medical history presented with dull pain/pressure in the left mandibular premolar region and the associated teeth were vital on pulp testing. Periapical radiograph revealed a well- circumscribed, radiolucent region measuring

Aim: Ludwig's angina is a rare aggressive infection, often of dental origin, characterized by a rapid spread of cellulitis in the submandibular and sublingual spaces. Ludwig's angina is potentially fatal, if it obstructs the airways and if it is not treated with appropriate antibiotic therapy. Summary: The case report describes the diagnosis and the management of a Ludwig's angina caused by an endodontic infection in a 16 years-old female patient. The infection has been caused by a decay of the second lower right molar. After hospitalization and systemic antibiotic therapy, in accordance with the patient and the parents endodontic and restorative treatments of the tooth were performed. After 3 and 5 years, the radiological examination revealed no periapical lesions around right lower second molar and the presence of lamina dura. Key learning points: This aggressive infection may often be undervalued and this may cause dangerous consequences to the patient's life. The infection can be prevented by periodic dental care and interventions, which can avoid odontogenic infections. In the case of Ludwig's angina, early diagnosis is fundamental to save the patient's life. After the initial antibiotic therapy and once the life of the patient is no longer at risk, an appropriate endodontic therapy can be considered a valid therapy for this disease. Riassunto: Obiettivi: L’angina di Ludwig è un’infezione aggressiva, spesso di origine odontogena, caratterizzata da una raccolta cellulitica a rapida evoluzione che coinvolge gli spazi sotto-mandibolare e sotto-linguale. Essa può ostruire le vie respiratorie ed essere potenzialmente fatale se non tempestivamente trattata con cure antibiotiche appropriate. Riassunto: In questo articolo viene descritto un caso di diagnosi e trattamento di un’angina di Ludwig causata da un’infezione odontogena in una ragazza di 16 anni. L’infezione é stata causata da una carie a carico del secondo molare inferiore di destra. Dopo il ricovero ospedaliero ed una terapia antibiotica sistemica parenterale, con il consenso dei genitori abbiamo è stata eseguita una terapia endodontica e la successiva ricostruzione con materiali adesivi dell’elemento dentario in questione. Dopo 3 e 5 anni gli esami radiografici mostrano assenza di lesioni periapicali e la presenza della lamina dura. Punti chiave di apprendimento: Questa infezione aggressiva è spesso sottovalutata e ciò può causare conseguenze gravi per la vita del paziente. Tali infezioni possono essere prevenute con controlli periodici del cavo orale. In caso di angina di Ludwig una diagnosi tempestiva è fondamentale per salvare la vita del paziente. Dopo l’iniziale terapia antibiotica ed aver messo in sicurezza la salute generale del paziente, la terapia endodontica può essere considerata una valida alternativa per questa patologia. Keywords: Ludwig's angina, Endodontic therapy, Endodontic infection, CBCT, Management infection, Parole chiave: Angina di Ludwig, Terapia endodontica, Infezione endodontica, CBCT, Gestione dell’infezione

Purpose Chitosan has been shown to promote wound healing and induce bone formation. The aim of this split-mouth study was to evaluate the effectiveness of chitosan based dressing in wound healing after lower third molar extraction. Method Asymptomatic symmetrical mandibular third molars were extracted simultaneously in 27 patients and Chitosan dressing was placed into the extraction socket in the test side. Pain scores were recorded on VAS using a 0 to 10 pain score. Wound healing was compared between right and left side. Radiographic findings were evaluated by observing lamina dura and density of extraction socket. Results Test group had more pain than control at all time intervals and unerupted tooth sites showed mean pain score significantly more than erupted tooth sites. Test group was superior to control in event of wound healing. Healing was significantly better in erupted tooth than unerupted tooth. At second week 12 sites showed better radiographic findings in chitosan treated group compared to 3 sites in the control group. At third month, 14 sites showed improved bone formation in chitosan treated group compared to 4 in control group. None of the unerupted teeth group showed better radiographic finding in test side at 2 week and 3 month compared to erupted teeth group. Conclusion Chitosan is effective in promoting wound healing and early osteogenesis in erupted tooth socket after extraction. We recommend that chitosan dressing should be used in the sockets of erupted tooth after extraction but should be avoided in unerupted or impacted teeth cases.

Objective: To analyze the relationship between age, body mass index (BMI), bone mineral density (BMD), and alveolar bone resorption with menopause duration in postmenopausal women. Material and Methods: A cross-sectional study was developed involving 59 subjects, aged 45 to 80 years and categorized the duration of menopause as ≤5 years and >5 years. Body mass index measurement and menopause duration were collected. Bone loss seen on radiography was measured by drawing a vertical line from the cementoenamel in the distal part of the 36 teeth and the mesial portion of 46 teeth to the base of the bone marked by the lamina dura intact. Categorical determinations of age, BMI, BMD, and alveolar bone resorption were based on receiver operating characteristic (ROC) curves. Were used Pearson correlation and Spearman correlation tests with the significance level set at 5%. Results: The majority of subjects (54.2%) with menopause duration >5 years were aged >54.5 years, most had BMI >24.2 kg/m2 (39%), had bone resorption >2.95 mm (52.5%), and had bone density ≤73.89 (49.2%). Pearson and Spearman correlation tests showed no significant correlation between age, BMI, bone density, and alveolar bone resorption (p>0.05). Conclusion: The longer the duration of menopause showed a tendency for lower bone density and higher age, BMI, and bone resorption.

Introduction The endodontic treatment of apical periodontitis (AP) without surgical intervention presents a unique clinical challenge. This case series aimed to test the changes in size of periapical lesion scale and healing in post-treatment of AP by cone beam computed tomography (CBCT) using Waveobe Gold reciprocating file with single cone treatment approach. Presentation of cases A total of 20 patients with 20 teeth (9 M, six premolars, one canine, and four incisors) with AP underwent CBCT scanning before and after non-surgical root canal treatment (NSRCT) or non-surgical retreatment (NSReTx). Standardized root canal chemo-debridement and instrumentation with WaveOne Gold (WOG) reciprocating files was used. The canals were obturated using epoxy-based sealer (AH Plus) with a single WaveOne Gold conform fit gutta-percha cone technique. After one year, assessment with CBCT images showed that the success and healing rate using (AH Plus) with single cone technique was very high. Discussion Apical periodontitis is an inflammatory disease at the root end of teeth. Following NSRCT or NSReTx, evaluation of lesion size by radiograph has been essential to the evaluation of lesions post-operatively. In addition to the absence of symptoms, complete restitution of the lamina dura and periodontal ligament (PDL) space on post-operative radiograph has been considered the optimal outcome success. Conclusions Within the limitations of this study, NSRCT or NSReTx using reciprocating WaveOne Gold and single cone with AH plus sealer resulted in healing of AP as assessed by CBCT., Highlights • This case series report consider the first clinical trial assessing the outcome of Non-surgical root canal treatment on healing of apical periodontitis by CBCT in different tooth types with primary apical periodontitis without endodontic treatment and post apical periodontitis with inadequate apical filling. • Within the limitations of this study, NSRCT or NSReTx using reciprocating WaveOne Gold files and single cone with AH plus sealer resulted in healing of AP as assessed by CBCT.

Background: Osteonecrosis of the Jaw (ONJ) - related to Bisphosphonates (BPs), denosumab, and other drugs - is a bone disease, that should be evaluated not only on base of clinical features (bone exposure and other signs or symptoms) but also by imaging tools, mostly Computed Tomography (CT) or Cone Beam Computed Tomography (CBCT). An Italian proposal of definition and staging is based on extension of bone alterations at CT scan study. Some scarce literature suggests that ONJ cases observed after denosumab might have different characteristics at CT scan. Methods: We reviewed CT relevant images at ONJ sites of patients developing ONJ after denosumab treatment only, looking for presence of radiological alteration signs. “Early signs” included: cortical disruption; markedly thickened and sclerotic lamina dura; trabecular thickening; focal bone marrow sclerosis; persisting alveolar socket; sequestra formation; widening of periodontal ligament space. “Late signs” included: oro-antral fistula; pathologic fracture; prominence of the inferior alveolar nerve canal; osteolysis extending to the sinus floor; diffuse osteosclerosis; osteosclerosis of adjacent bones (zygoma; hard palate); periosteal reaction; sinusitis. Cases of patients receiving BPs and shifted to denosumab were excluded. The results were compared with similar data collected by CT scans of ONJ patients treated with zoledronic acid only. The ONJ stage according to Italian staging system (stage 1, focal ONJ; stage 2, diffuse ONJ; stage 3, complicated ONJ) was adopted in both the groups. Results: We evaluated CT scans of patients treated with denosumab, developing ONJ. After exclusion of patients shifted to denosumab after biphosphonates, 8 patients were found as receiving denosumab only and their CT scan findings were compared with those of 10 ONJ cases observed after zoledronic acid treatment, randomly selected in a database of 103 ONJ cases. Tha stage resulted more advanced in cases after zoledronic acid treatment. Preliminary analysis indicate that frequency of the single characteristics might be slightly different in the two patient populations; particularly diffuse osteosclerosis was less frequent in this little sample of patients receiving denosumab (2 out of 8 cases) in comparison with those ones receiving zoledronic acid (7 out of 10 cases). Conclusions: A large multicentre retrospective and prospective study is warranted and hopeful, aimed to clarify the differences on CT alterations in denosumab-related and BP-related ONJ cases.

Background Central giant cell granuloma (CGCG) is one of the most intriguing lesions of the jaws and its nature has not yet been fully elucidated. Clinically, some CGCG behave more aggressively, while others have an indolent course. In cases of aggressive CGCG of the maxilla, effective personalized therapies are worth understanding. Case report We report here a challenging case of aggressive CGCG in a 15-year-old girl which was misdiagnosed as an endodontic lesion. Radiographically, a large osteolytic lesion involving the hard palate from the central incisor to the second premolar, extending into the nasal cavity, with loss of the lamina dura and cortical resorption was observed. The lesion expanded aggressively after extensive curettage. With possible mutilation and defects due to a more radical approach to the lesion, treatment with systemic prednisone and intralesional triamcinolone hexacetonide associated with a calcitonin nasal spray was instituted. The decision in favor of this therapeutic strategy was made after careful immunohistochemical analysis of calcitonin and glucocorticoid receptors. The H-score for the staining of glucocorticoid and calcitonin receptors in multinucleated giant cells was 222 and 153.6, respectively. The lesion reduced in size, and no adverse effects associated with medications were observed. Another curettage was performed, and only fibrous connective tissue was found. The patient is in follow-up for 11 years without evidence of recurrence. Conclusion Pharmacological agents hold clinical promise in cases of aggressive CGCG affecting the maxilla of pediatric patients. Investigating the expression of calcitonin and glucocorticoid receptors in order to plan treatment is very helpful in the decision to manage aggressive CGCG.

Background. This study aimed to assess the prevalence of missed canals in endodontically treated teeth and their association with apical periodontitis in a Saudi Arabian population using CBCT. Materials and Methods. A total of 208 CBCT radiographs were investigated. For each tooth, radiographs of axial, coronal, and sagittal segments were acquired to appraise the external as well as the internal structure of the root canal system and apical area. In root canal-treated teeth, unfilled canals appearing from the cementoenamel junction to the apex were defined as missed untreated canals; and a periapical lesion was considered when disruption of the lamina dura was detected, and the low-density area associated with the radiographic apex was at least twice the width of the periodontal ligament space. The data were presented as frequencies and percentages. The Z-test was used to analyze the differences in proportions with the significance level set at P value

Objective Hypercalcemia is determined as an increase in the serum calcium level (above 10.5 mg/dL or ionized calcium is above 1.5 mmol/L). It was aimed to evaluate the effect of the increased serum calcium levels in dental panoramic radiographs with oral pathologies. Materials & Methods The final sample number of the present study was determined as 143. 61 patients with hypercalcemic calcium levels were grouped in Hypercalcemia Group (HPEG) whereas 82 patients were grouped in Normal Group. (NG) Measurements were performed only on the panoramic radiographs. The evaluated parameters were cyst-tumor or granuloma existence, sinus pneumatization, stylohyoid ligament calcifications, lamina dura loss, bone loss existence, etc. Statistical tests were carried out at p Results The cyst-tumor formation (p = 0.03) and stylohyoid ligament calcification (p = 0.009) and increased radiopacity (p = 0.03) were significantly more common in NG than the HPEG group. Alveolar bone loss (p = 0.001) and periodontal defects (p = 0.01) were significantly more common in HPEG than the NG group. There was no significant relationship between other examined parameters. (p > 0.05) Conclusion The serum calcium level revealed statistically significant outcomes and a close relationship with the pathologies occurring in the alveolar bone in the oral and maxillofacial region. However, it is highly recommended to include more patients in the newly planned studies and another bone-related biomarker should be evaluated simultaneously.

Internal root resorption is characterised by progressive loss of tooth substance initiating at the root canal wall as a result of clastic activity. This report describes a case of a perforating internal root resorption on a maxillary central incisor in a 25-year-old patient. The perforating internal root resorption was firstly diagnosed with periapical radiographs and assessed with full detail with the aid of CBCT, allowing determination of the extension and areas involved in the resorption lesion, as well as the treatment planning. According to these findings, a MTA barrier was performed on the root, -coronally to the resorption lesion, leaving the root apically to the resorption lesion untouched. Clinical findings and periapical radiographs indicated complete resolution of the radiolucency associated with the resorptive defect, with reestablishment of lamina dura along the root and occlusion of the lumen of the root canal in the apical segment, after a 5-year follow-up.

A simple bone cyst (SBC) is an intrabone cavity without epithelial lining, which occasionally occur with fibrous-osseous lesions. The imaging finding of the scalloped border and conserving the lamina dura, periodontal ligament spaces, or follicular spaces are considered radiographically pathognomonic of SBC. SBC has been reported to occur with fibrous-osseous lesions, including cemento-osseous dysplasia (COD). Computed tomography (CT) imaging findings are sparse, and there are no reports of magnetic resonance imaging (MRI) findings, including apparent diffusion coefficient (ADC) value calculated by diffusion-weighted MRI for the florid COD-associated SBC. We report a case of a 39-year-old woman who was referred to our hospital because a panoramic radiograph of her right mandible showed asymptomatic radiolucency in the apical molar area. CT images showed a low-density lesion in the periapical areas of the right mandible, which accompanied a well-defined, high-density lesion, and a mixed low/high-density lesion with an unusual marked irregular border in the left mandible. The MRI showed cyst-like extremely hyperintense signals on fat-suppressed T2-weighted images at the right mandibular low-density and the left mandibular mixed low/high-density areas. ADC map showed high values (over 2.5×10−3 mm2/s) at the cystic areas in the bilateral mandible. We performed incisional biopsies of the bilateral mandibular lesions and resections of the bilateral maxillary lesions. Surgical and histopathological findings established a diagnosis of florid COD in the bilateral mandible and maxilla, simultaneously complicated by multiple SBCs in the bilateral mandible. The ADC value of cystic component is useful for the diagnosis, if the COD-associated SBC exhibits solitary, nonspecific, or rare imaging findings.

Introduction: Teeth frequently fail to erupt and situations arise that prevent the canines from reaching the occlusal plane. Objective: Discourse about the three situations in which the canine does not reach the occlusal plane, and remains unerupted; and at the same time, point how to make a safe diagnosis of alveolodental ankylosis - one of the three causes -, based on tomography. Conclusions: Ankylosis occurs in impacted teeth by atrophy of the periodontal ligament, including the epithelial rests of Malassez. The tomographic signs of alveolodental ankylosis in unerupted canines are the interruption of hypodense periodontal space, discontinuity of the lamina dura and its continuity with the root surface, which gradually loses its regular shape. RESUMO Introdução: Muitas vezes, a erupção falha, e ocorrem situações que impedem que os caninos cheguem até o plano oclusal. Objetivos: Discorrer sobre quais as três situações nas quais o canino não chega até o plano oclusal, permanecendo não irrompido e, ao mesmo tempo, destacar como se diagnosticar com segurança uma dessas três causas, a anquilose alveolodentária, a partir da tomografia. Conclusões: A anquilose em dentes não irrompidos ocorre pela atrofia do ligamento periodontal, incluindo os Restos Epiteliais de Malassez. Os sinais tomográficos de uma anquilose alveolodentária em caninos não irrompidos são a interrupção do espaço periodontal hipodenso, a descontinuidade da lâmina dura e a sua continuidade com a superfície radicular, que, gradativamente, perde sua regularidade.

Background and Overview Cone-beam computerized tomographic (CBCT) imaging is increasingly used in the maxillofacial region for various purposes. The volumetric dataset created by means of CBCT increases the possibility of detecting incidental findings. Case Description In this case report, the authors describe an otherwise healthy 45-year-old man who was referred from the Sjogren's Syndrome Center in Jerusalem, Israel, for bilateral parotid CBCT sialographic imaging owing to xerostomia lasting for 4 months. CBCT sialographic imaging using iodine contrast material showed normal glandular structure and activity according to the postcannulation panoramic imaging. CBCT sialographic imaging routine volume interpretation revealed a lesion in the mandibular area causing destruction and perforation of the cortical plates, partial disappearance of adjacent lamina dura, and resorption of adjacent teeth, suggesting an aggressive benign tumor. Histopathologic examination confirmed mural cystic ameloblastoma, which was resected with preservation of the mental nerve and the lower mandibular border. The patient received bone graft and implants, with regular follow-ups and no recurrence after 4 years. Conclusions and Practical Implications This case strengthens the need for thorough examination of the whole CBCT imaging volume within and outside the region of interest to detect incidental findings with clinical importance.

Chronic pulpal inflammation and infection are the main predisposing factors for internal and external root resorption (IRR & ERR); however, merging of IRR and ERR is a rare lesion which rigorously alters the anatomy of root canals. This study reports a case of merged IRR and ERR in an asymptomatic maxillary left central incisor in a 33-year old Caucasian woman that was managed by one-visit root canal therapy (RCT) using calcium-enriched mixture (CEM) cement. Radiographic examination showed a short root with under-filled root canal obturation associated with ERR/IRR and an apical lesion. After thorough chemo-mechanical preparation, the root canal was obturated with CEM cement; one week later, the access cavity was permanently restored. Clinical/radiographic examinations at 1-year follow-up revealed uneventful healing, reestablishment of lamina dura and stabilization of the resorptive defects. The treatment outcome demonstrates that one-visit RCT using CEM cement may be a viable treatment option in cases with merged external/internal root resorption. Further clinical trials with a larger number of cases are suggested to document a higher level of evidence.

Lateral periodontal cysts (LPCs) are rare odontogenic cysts of developmental origin. A 52-year-old man presented with an asymptomatic gingival swelling located between the mandibular left canine and first premolar, both of which were vital. Radiography showed a well-circumscribed radiolucent area and loss of the lamina dura around the tooth socket in contact with the lesion and of the interproximal buccal bone. The lesion was enucleated. The defect was immediately grafted with a 1:1 mixed autologous and heterologous bone graft covered with a collagen membrane. Histology confirmed the diagnosis of LPC. At 12- and 24-month clinical and radiologic follow-up, complete bone and periodontal healing was found, with no sign of recurrence.

Deep carious lesions in immature permanent molars with pulp necrosis pose a serious challenge to contemporary paedodontic practice. A further complex clinical scenario is an immature permanent molar with varying root formation in both roots. This case report demonstrates the successful management of an immature permanent mandibular first molar. An 8-year-old boy was referred for endodontic management of 36 by a general practitioner. After clinical and radiographic evaluation, a diagnosis of recurrent chronic periapical abscess with abrupt root closure in the mesial root and cessation of root closure in the distal root was made. Apexification was undertaken in three appointments. In the first appointment, under local analgesia and isolation, the mesial canals were prepared to size #F3 with rotary Protaper Universal and the distal canal was left unprepared. Both canals were irrigated with 5% sodium hypochlorite and calcium hydroxide intracanal medicament was placed. One week later, the mesial canals were obturated and a 4 mm white MTA apical plug was placed in the distal canal. Partial extrusion of the MTA was seen periapically. After 24 h, the hard-setting of the MTA plug was verified, remainder of the distal canal was obturated and core filling was placed followed by a preformed metal crown as an intermediate restoration. The patient was asymptomatic and showed resolution of the lesion, normal thickness of the PDL space with continuity of the lamina dura after 12 months. Extruded MTA was partially resorbed. Three years follow-up showed complete resorption of the extruded MTA and an intact lamina dura.

Dentin sialophosphoprotein (DSPP) plays an important role in the mineralization of both dentin and bones. The Dspp null mice developed periodontal diseases. Patients with DSPP mutations have dentinogenesis imperfecta (DGI), but very little is known about their bone characteristics. This study aims to characterize alveolar bone cells of a DGI patient with DSPP mutation. Pathogenic variants were identified by whole exome and sanger sequencing. Cells isolated from the alveolar bones of a DSPP patient were investigated for their characteristics including cell morphology, attachment, spreading, proliferation, colony formation, mineralization, and osteogenic differentiation. We identified a Thai family with three members affected with autosomal dominant DGI harboring a heterozygous pathogenic missense mutation, c.50C > T, p.P17L, in exon 2 of the DSPP gene. The patients’ phenotypes presented deteriorated opalescent teeth with periapical lesions, thickening of lamina dura, furcation involvement, alveolar bone loss, and bone exostoses. The alveolar bone cells isolated from DSPP patient exhibited compromised proliferation and colony formation. Scanning electron microscope revealed altered cellular morphology and spreading. The DSPP cells showed deviated mRNA levels of OCN, ALP, and COL1 but maintained in vitro mineralization ability compared to the control. We demonstrate that the DSPP p.P17L mutant alveolar bone cells had compromised cell spreading, proliferation, colony formation, and osteogenic induction, suggesting abnormal bone characteristics in the patient with DGI caused by DSPP mutation. DSPP mutation can induce the behavior alterations of alveolar bone cells.

Background This study evaluated the relationship between radiographic crestal alveolar bone morphology and progressive periodontitis. Methods A total of 1,356 posterior interproximal sites in 56 adults treated for chronic periodontitis and receiving systematic 3-month maintenance care were scored for angular or horizontal marginal bone morphology, as well as for alveolar crestal lamina dura, on radiographs obtained at baseline of a 30-month post-treatment period. Semi-annually, the study patients were clinically evaluated for progressive periodontitis. Logistic regression analysis assessed baseline parameters to progressive periodontitis over the 30-month post-treatment period. Results Progressive periodontitis was detected at 33 (2.4%) posterior interproximal sites in 20 (35.7%) patients. Sites with post-treatment angular bony defects developed progressive periodontitis more frequently (14.7%) than sites with a horizontal bone topography (1.8%). Angular bony defects (odds ratio = 10.6) and periodontal probing depths ≥5 mm (odds ratio = 4.2) were identified as statistically significant independent predictors of progressive periodontitis at posterior interproximal sites. Angular bony and horizontal lesions with intact radiographic lamina dura revealed an absence of progressive periodontitis through 24 months. Conclusions Post-treatment presence of angular bone morphology and periodontal probing depths ≥5 mm significantly increased risk of progressive periodontitis at posterior interproximal sites. Sites of all morphology and probing depth that displayed radiographic crestal lamina dura at post-treatment baseline exhibited clinical stability for ≥24 months.

Purpose This study aimed to investigate the prevalence of juxta-apical radiolucency (JAR), assessing its association with third molar status and describing its radiologic features through panoramic radiography. Materials and Methods We evaluated 1,050 radiographs (1,830 third molars) for the presence of JAR. The JAR and control groups were classified according to the third molar's angulation, impaction, and root development. The presence of radiographic signs of proximity between the mandibular canal and third molar and the imaging features of JAR also were recorded. Results JAR was identified in 116 patients (11%) and 130 third molars (7.1%), being significantly associated with female patients and with the second and third decades of life. There also was an association with teeth with a vertical angulation and complete root formation. Radiographic signs of proximity to the mandibular canal were absent in 66.2% of JAR cases. In most cases, there was lamina dura in the juxta-apical area that appeared to overlap the mandibular canal and to have a cortical outline. Conclusions JAR is not a rare imaging finding. Given its possible relationship with nerve injuries and its differential diagnostic possibilities, knowing the characteristics of JAR is important to assist professionals in treatment planning and making the correct diagnosis.

BACKGROUND: The hyperparathyroidism (HPT) is a condition in which the parathyroid hormone (PTH) levels in the blood are increased. HPT is categorised into primary, secondary and tertiary. A rare entity that occurs in the lower jaw in association with HPT is the so-called brown tumour, which an osteolytic lesion is predominantly occurring in the lower jaw. It is usually a manifestation of the late stage of the disease. Osteosclerotic changes in other bones are almost always associated with renal osteodystrophy in secondary HPT and are extremely rare in primary HPT. This article reports a rare case of a brown tumour in the mandible as the first sign of a severe primary HPT, associated with osteosclerotic changes on the skull.CASE REPORT: A brown tumour in the mandible was diagnosed in 60 - year old female patient with no previous history of systemic disease. The x - rays showed radiolucent osteolytic lesion in the frontal area of the mandible affecting the lamina dura of the frontal teeth, and skull osteosclerosis in the form of salt and pepper sign. The blood analyses revealed increased values of PTH, calcitonin and β – cross-laps, indicating a primary HPT. The scintigraphy of the parathyroid glands showed a presence of adenoma in the left lower lobe. The tumour lesion was surgically removed together with the lower frontal teeth, and this was followed by total parathyroidectomy. The follow - up of one year did not reveal any signs of recurrence.CONCLUSION: It is critical to ensure that every osteolytic lesion in the maxillofacial region is examined thoroughly. Moreover, a proper and detailed systemic investigation should be performed. Patients should undergo regular check-ups to prevent late complications of HPT.