1. EAACI position paper: Influence of dietary fatty acids on asthma, food allergy, and atopic dermatitis
- Author
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Berber Vlieg-Boerstra, Rosan Meyer, Cezmi A. Akdis, Antonella Muraro, Mary Feeney, Karine Adel-Patient, Sylwia Smolinska, Kate Maslin, Holger Garn, Ioana Agache, Isabella Pali-Schöll, Graham Roberts, Caroline Roduit, Karin Hoffmann-Sommergruber, Lars K. Poulson, Remo Frei, Bright I Nwaru, Harald Renz, Eva Untersmayr, George Du Toit, Matthew Greenhawt, Peter K. Smith, Carina Venter, Catherine Stanton, Stephan C. Bischoff, Liam O'Mahony, Clare Mills, Carlo Agostoni, Milena Sokolowska, Imke Reese, Nonhlanhla Lunjani, University of Colorado, University of Colorado [Boulder], Imperial College London, University of Gothenburg (GU), University Children’s Hospital Zurich, Medizinische Universität Wien = Medical University of Vienna, Service de Pharmacologie et Immunoanalyse (SPI), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Paris Saclay (COmUE), Sapientia Hungarian University of Transylvania, Ospedale Maggiore Policlinico, Università degli Studi di Milano = University of Milan (UNIMI), Christine Kühne Center, Partenaires INRAE, Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), University of Hohenheim, King‘s College London, Guy's and St Thomas' Hospitals, Philipps Universität Marburg = Philipps University of Marburg, University of Colorado Anschutz [Aurora], University of Cape Town, MRC Lifecourse Epidemiology Unit, University of Southampton, School of Biological Sciences, Manchester Academic Health Sciences Centre, Manchester Institute of Biotechnology, University of Manchester, Università degli Studi di Padova = University of Padua (Unipd), Copenhagen University Hospitals, Dietary Counseling and Nutrition Therapy Centre, Institute of Laboratory Medicine, Helios-Hospital, The David Hide Asthma and Allergy Research Centre, St Mary's Hospital-University Hospital Southampton NHS Foundation Trust, NIHR Biomedical Research Centre, Griffith University [Brisbane], Department of Clinical Immunology, Wrocław Medical University, APC Microbiome Ireland, University College Cork (UCC), OLVG, Service de Pharmacologie et d'Immunoanalyse (SPI), Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Università degli Studi di Milano [Milano] (UNIMI), Philipps University of Marburg, Universita di Padova, Griffith University, and Wroclaw Medical University
- Subjects
0301 basic medicine ,Allergy ,Lydia Becker Institute ,[SDV]Life Sciences [q-bio] ,allergic ,chemistry.chemical_compound ,0302 clinical medicine ,Epidemiology ,Immunology and Allergy ,Rhinitis ,2. Zero hunger ,dietary fatty acids ,Fatty Acids ,Age Factors ,Atopic dermatitis ,3. Good health ,Food Hypersensitivity ,altered environmenta ,Signal Transduction ,Adult ,medicine.medical_specialty ,Immunology ,Dermatitis, Atopic ,Immunomodulation ,03 medical and health sciences ,Immune system ,Food allergy ,ResearchInstitutes_Networks_Beacons/lydia_becker_institute_of_immunology_and_inflammation ,Manchester Institute of Biotechnology ,medicine ,Animals ,Humans ,Microbiome ,Nutrition ,Asthma ,Fatty acid metabolism ,business.industry ,Infant, Newborn ,Infant ,ResearchInstitutes_Networks_Beacons/manchester_institute_of_biotechnology ,Lipid Metabolism ,medicine.disease ,Dietary Fats ,Disease Models, Animal ,030104 developmental biology ,030228 respiratory system ,chemistry ,business - Abstract
International audience; The prevalence of allergic diseases such as allergic rhinitis, asthma, food allergy, and atopic dermatitis has increased dramatically during the last decades, which is associated with altered environmental exposures and lifestyle practices. The purpose of this review was to highlight the potential role for dietary fatty acids, in the prevention and management of these disorders. In addition to their nutritive value, fatty acids have important immunoregulatory effects. Fatty acid-associated biological mechanisms, human epidemiology, and intervention studies are summarized in this review. The influence of genetics and the microbiome on fatty acid metabolism is also discussed. Despite critical gaps in our current knowledge, it is increasingly apparent that dietary intake of fatty acids may influence the development of inflammatory and tolerogenic immune responses. However, the lack of standardized formats (ie, food versus supplement) and standardized doses, and frequently a lack of prestudy serum fatty acid level assessments in clinical studies significantly limit our ability to compare allergy outcomes across studies and to provide clear recommendations at this time. Future studies must address these limitations and individualized medical approaches should consider the inclusion of specific dietary factors for the prevention and management of asthma, food allergy, and atopic dermatitis.
- Published
- 2019