131 results on '"Latorre, Daniela"'
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2. On group actions on Riemann-Roch spaces of curves
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Carocca, Angel and Vásquez Latorre, Daniela
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- 2024
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3. Narcolepsy: a model interaction between immune system, nervous system, and sleep-wake regulation
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Latorre, Daniela, Sallusto, Federica, Bassetti, Claudio L. A., and Kallweit, Ulf
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- 2022
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4. Expanding our understanding of Guillain–Barré syndrome: Recent advances and clinical implications.
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Ripellino, Paolo, Schreiner, Bettina, and Latorre, Daniela
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PERIPHERAL nervous system ,T cells ,DISEASE management ,AUTOIMMUNITY ,IMMUNOPATHOLOGY ,AUTOIMMUNE diseases - Abstract
Guillain–Barré syndrome (GBS) is a rare yet potentially life‐threatening disorder of the peripheral nervous system (PNS), characterized by substantial clinical heterogeneity. Although classified as an autoimmune disease, the immune mechanisms underpinning distinct GBS subtypes remain largely elusive. Traditionally considered primarily antibody‐mediated, the pathophysiology of GBS lacks clarity, posing challenges in the development of targeted and effective treatments. Nevertheless, recent investigations have substantially expanded our understanding of the disease, revealing an involvement of autoreactive T cell immunity in a major subtype of GBS patients and opening new biomedical perspectives. This review highlights these discoveries and offers a comprehensive overview of current knowledge about GBS, including ongoing challenges in disease management. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria
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Yang, Rui, Mele, Federico, Worley, Lisa, Langlais, David, Rosain, Jérémie, Benhsaien, Ibithal, Elarabi, Houda, Croft, Carys A., Doisne, Jean-Marc, Zhang, Peng, Weisshaar, Marc, Jarrossay, David, Latorre, Daniela, Shen, Yichao, Han, Jing, Ogishi, Masato, Gruber, Conor, Markle, Janet, Al Ali, Fatima, Rahman, Mahbuba, Khan, Taushif, Seeleuthner, Yoann, Kerner, Gaspard, Husquin, Lucas T., Maclsaac, Julia L., Jeljeli, Mohamed, Errami, Abderrahmane, Ailal, Fatima, Kobor, Michael S., Oleaga-Quintas, Carmen, Roynard, Manon, Bourgey, Mathieu, El Baghdadi, Jamila, Boisson-Dupuis, Stéphanie, Puel, Anne, Batteux, Fréderic, Rozenberg, Flore, Marr, Nico, Pan-Hammarström, Qiang, Bogunovic, Dusan, Quintana-Murci, Lluis, Carroll, Thomas, Ma, Cindy S., Abel, Laurent, Bousfiha, Aziz, Di Santo, James P., Glimcher, Laurie H., Gros, Philippe, Tangye, Stuart G., Sallusto, Federica, Bustamante, Jacinta, and Casanova, Jean-Laurent
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- 2020
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6. Editorial: T cell specificity and cross-reactivity – implications in physiology and pathology
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Latorre, Daniela, primary, Monticelli, Silvia, additional, Wypych, Tomasz P., additional, Aschenbrenner, Dominik, additional, and Notarbartolo, Samuele, additional
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- 2024
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7. Correction to: Narcolepsy: a model interaction between immune system, nervous system, and sleep-wake regulation
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Latorre, Daniela, Sallusto, Federica, Bassetti, Claudio L. A., and Kallweit, Ulf
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- 2022
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8. Narrow-Angle Glaucoma
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Galvis, Juan Carlos Rueda, primary, Uzcategui, Mary Alejandra Sánchez, additional, Latorre, Daniela Rueda, additional, and Latorre, Isabella Rueda, additional
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- 2023
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9. Glaucoma de Ángulo Estrecho
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Galvis, Juan Carlos Rueda, primary, Uzcategui, Mary Alejandra Sánchez, additional, Latorre, Daniela Rueda, additional, and Latorre, Isabella Rueda, additional
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- 2023
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10. T cells targeting peripheral nerves are expanded and shared in patients with Guillain-Barré Syndrome.
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Latorre, Daniela, primary, Súkeníková, Lenka, additional, Mallone, Anna, additional, Schreiner, Bettina, additional, Ripellino, Paolo, additional, Nilsson, Jakob, additional, and Sallusto, Federica, additional
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- 2023
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11. Human CD4+ T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro
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Nishihara, Hideaki, Soldati, Sasha, Mossu, Adrien, Rosito, Maria, Rudolph, Henriette, Muller, William A., Latorre, Daniela, Sallusto, Federica, Sospedra, Mireia, Martin, Roland, Ishikawa, Hiroshi, Tenenbaum, Tobias, Schroten, Horst, Gosselet, Fabien, and Engelhardt, Britta
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- 2020
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12. T cells in patients with narcolepsy target self-antigens of hypocretin neurons
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Latorre, Daniela, Kallweit, Ulf, Armentani, Eric, Foglierini, Mathilde, Mele, Federico, Cassotta, Antonino, and Jovic, Sandra
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Narcolepsy -- Genetic aspects -- Risk factors -- Diagnosis -- Care and treatment ,T cells -- Research ,Influenza vaccines ,Lymphocytes ,Neurons ,Antigens ,Antigenic determinants ,HLA antigens ,Autoimmunity ,Vaccination ,Influenza ,B cells ,Sleep disorders ,Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
Narcolepsy is a chronic sleep disorder caused by the loss of neurons that produce hypocretin. The close association with HLA-DQB1*06:02, evidence for immune dysregulation and increased incidence upon influenza vaccination together suggest that this disorder has an autoimmune origin. However, there is little evidence of autoreactive lymphocytes in patients with narcolepsy. Here we used sensitive cellular screens and detected hypocretin-specific CD4.sup.+ T cells in all 19 patients that we tested; T cells specific for tribbles homologue 2--another self-antigen of hypocretin neurons--were found in 8 out of 13 patients. Autoreactive CD4.sup.+ T cells were polyclonal, targeted multiple epitopes, were restricted primarily by HLA-DR and did not cross-react with influenza antigens. Hypocretin-specific CD8.sup.+ T cells were also detected in the blood and cerebrospinal fluid of several patients with narcolepsy. Autoreactive clonotypes were serially detected in the blood of the same--and even of different--patients, but not in healthy control individuals. These findings solidify the autoimmune aetiology of narcolepsy and provide a basis for rapid diagnosis and treatment of this disease.The detection of hypocretin-specific autoreactive CD4.sup.+ and CD8.sup.+ T cells in patients with narcolepsy reveals the autoimmune aetiology of this disorder., Author(s): Daniela Latorre [sup.1] [sup.2] , Ulf Kallweit [sup.3] [sup.4] , Eric Armentani [sup.1] , Mathilde Foglierini [sup.1] [sup.5] , Federico Mele [sup.1] , Antonino Cassotta [sup.1] [sup.2] , Sandra [...]
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- 2018
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13. Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency
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Kong, Xiao-Fei, Martinez-Barricarte, Ruben, Kennedy, James, Mele, Federico, Lazarov, Tomi, Deenick, Elissa K., Ma, Cindy S., Breton, Gaëlle, Lucero, Kimberly B., Langlais, David, Bousfiha, Aziz, Aytekin, Caner, Markle, Janet, Trouillet, Céline, Jabot-Hanin, Fabienne, Arlehamn, Cecilia S. Lindestam, Rao, Geetha, Picard, Capucine, Lasseau, Théo, Latorre, Daniela, Hambleton, Sophie, Deswarte, Caroline, Itan, Yuval, Abarca, Katia, Moraes-Vasconcelos, Dewton, Ailal, Fatima, Ikinciogullari, Aydan, Dogu, Figen, Benhsaien, Ibtihal, Sette, Alessandro, Abel, Laurent, Boisson-Dupuis, Stéphanie, Schröder, Bernd, Nussenzweig, Michel C., Liu, Kang, Geissmann, Frédéric, Tangye, Stuart G., Gros, Philippe, Sallusto, Federica, Bustamante, Jacinta, and Casanova, Jean-Laurent
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- 2018
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14. Editorial: Knocking on neuroimmunology’s doors: an entrechat concerning the immune system balance and its cell metabolism orchestration
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Sambucci, Manolo, primary, Dardalhon, Valérie, additional, and Latorre, Daniela, additional
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- 2023
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15. Corneal endothelium assessment in specular microscopy images with Fuchs’ dystrophy via deep regression of signed distance maps
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Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria, Universitat Politècnica de Catalunya. GOAPI - Grup d'Òptica Aplicada i Processament d'Imatge, Sierra Bravo, Juan Sebastián, Pineda, Jesús, Rueda Latorre, Daniela, Trello, Alejandro, Prada, Angélica M., Galvis Ramírez, Virgilio, Volpe, Giovanni, Millán Garcia-Varela, M. Sagrario, Romero Pérez, Lenny Alexandra, Marrugo Hernandez, Andrés Guillermo, Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria, Universitat Politècnica de Catalunya. GOAPI - Grup d'Òptica Aplicada i Processament d'Imatge, Sierra Bravo, Juan Sebastián, Pineda, Jesús, Rueda Latorre, Daniela, Trello, Alejandro, Prada, Angélica M., Galvis Ramírez, Virgilio, Volpe, Giovanni, Millán Garcia-Varela, M. Sagrario, Romero Pérez, Lenny Alexandra, and Marrugo Hernandez, Andrés Guillermo
- Abstract
Specular microscopy assessment of the human corneal endothelium (CE) in Fuchs’ dystrophy is challenging due to the presence of dark image regions called guttae. This paper proposes a UNet-based segmentation approach that requires minimal post-processing and achieves reliable CE morphometric assessment and guttae identification across all degrees of Fuchs’ dystrophy. We cast the segmentation problem as a regression task of the cell and gutta signed distance maps instead of a pixel-level classification task as typically done with UNets. Compared to the conventional UNet classification approach, the distance-map regression approach converges faster in clinically relevant parameters. It also produces morphometric parameters that agree with the manually-segmented ground-truth data, namely the average cell density difference of -41.9 cells/mm2 (95% confidence interval (CI) [-306.2, 222.5]) and the average difference of mean cell area of 14.8 µm 2 (95% CI [-41.9, 71.5]). These results suggest a promising alternative for CE assessment., This work has been partly funded by Ministerio de Ciencia, Tecnología e Innovación, Colombia, Project 124489786239 (Contract 763-2021), Universidad Tecnológica de Bolívar (UTB) Project CI2021P02, and Agencia Estatal de Investigación del Gobierno de España (PID2020-114582RB-I00/ AEI / 10.13039/501100011033). J. Sierra thanks UTB for a post-graduate scholarship., Peer Reviewed, Postprint (published version)
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- 2023
16. Distinct migratory pattern of naive and effector T cells through the blood–CSF barrier following Echovirus 30 infection
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Wiatr, Marie, Stump-Guthier, Carolin, Latorre, Daniela, Uhlig, Stefanie, Weiss, Christel, Ilonen, Jorma, Engelhardt, Britta, Ishikawa, Hiroshi, Schwerk, Christian, Schroten, Horst, Tenenbaum, Tobias, and Rudolph, Henriette
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- 2019
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17. The swiss young immunologists society (SYIS): Empowering the next generation of immunologists
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Latorre, Daniela, Hausmann, Annika, Krishnarajah, Sinduya, Weiden, Jorieke, Näf, Pascal, and Bull, Anna Estrada
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610 Medizin und Gesundheit - Published
- 2023
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18. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations
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Okada, Satoshi, Markle, Janet G., Deenick, Elissa K., Mele, Federico, Averbuch, Dina, Lagos, Macarena, Alzahrani, Mohammed, Al-Muhsen, Saleh, Halwani, Rabih, Ma, Cindy S., Wong, Natalie, Soudais, Claire, Henderson, Lauren A., Marzouqa, Hiyam, Shamma, Jamal, Gonzalez, Marcela, Martinez-Barricarte, Rubén, Okada, Chizuru, Avery, Danielle T., Latorre, Daniela, Deswarte, Caroline, Jabot-Hanin, Fabienne, Torrado, Egidio, Fountain, Jeffrey, Belkadi, Aziz, Itan, Yuval, Boisson, Bertrand, Migaud, Mélanie, Arlehamn, Cecilia S. Lindestam, Sette, Alessandro, Breton, Sylvain, McCluskey, James, Rossjohn, Jamie, de Villartay, Jean-Pierre, Moshous, Despina, Hambleton, Sophie, Latour, Sylvain, Arkwright, Peter D., Picard, Capucine, Lantz, Olivier, Engelhard, Dan, Kobayashi, Masao, Abel, Laurent, Cooper, Andrea M., Notarangelo, Luigi D., Boisson-Dupuis, Stéphanie, Puel, Anne, Sallusto, Federica, Bustamante, Jacinta, Tangye, Stuart G., and Casanova, Jean-Laurent
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- 2015
19. Functional heterogeneity of human memory CD4 + T cell clones primed by pathogens or vaccines
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Becattini, Simone, Latorre, Daniela, Mele, Federico, Foglierini, Mathilde, De Gregorio, Corinne, Cassotta, Antonino, Fernandez, Blanca, Kelderman, Sander, Schumacher, Ton N., Corti, Davide, Lanzavecchia, Antonio, and Sallusto, Federica
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- 2015
20. Autoimmunity and SARS‐CoV‐2 infection: Unraveling the link in neurological disorders
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Latorre, Daniela, primary
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- 2022
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21. Computational tool for the simulation of autoamtic events in active distribution networks
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Férnandez, Mildre José, Latorre, Daniela Carolina, Orozco, Cesar Augusto, and Marín, Juan Guillermo
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Microrredes, herramienta computacional, fuentes renovables, sistemas de distribución ,Microgrids, computational tool, renewable sources, distribution systems - Abstract
En la actualidad, existe un déficit de herramientas computacionales de bajo costo para modelar y simular distintas condiciones de operación de las microrredes con fuentes de generación no convencionales. Por está razón, nuestro proyecto desarrolló la herramienta SEM ( Simulación - Eventos - Microrredes ) en ATP-EMTP con interfaz en PyQt de Python, que simula automáticamente eventos en escenario de operación normal y fallas de baja impedancia en sistemas de distribución que incluyen fuentes no convencionales. Durante el desarrollo de este proyecto, fuimos cuidadosos del cumplimiento de las normas (IEC 60909, ANSI/IEEE 141-4, IEEE 399) y además contemplamos restricciones de ingeniería. Por ejemplo, restricciones económicas garantizando que el proyecto fuera de bajo presupuesto; restricciones ambientales contemplando que este proyecto contribuya en la reducción de gases de efecto invernadero y tecnológicas mediante la implementación de tecnologías informáticas. El proceso de validación experimental de funcionamiento de la herramienta se realizó mediante la implementación de los sistemas IEEE 34 nodos e IEEE 123 nodos. Se desarrollaron casos de estudios en ambos sistemas que fueron solucionados de forma manual y automática. En conclusión, se demostró que la herramienta SEM cumplió con el objetivo de simular y enriquecer la base de datos de escenarios de operación normal y bajo condiciones de falla para el estudio de microrredes. Los impactos de la herramienta son : tecnológico debido a que es una herramienta muy importante para el diseño de las protecciones de microrredes, específicamente aquellas que cuentan con fuentes no convencionales de energía; económico porque el costo de producción del prototipo es inferior que el de otro software con las mismas características. Nowadays, there is a deficit of low-cost computational tools for the simulation of different operating conditions in microgrids with unconventional generation sources. For this reason, we developed SEM computational tool (Simulation - Events - Microgrids) in ATP-EMTP with a Python PyQt5 interface, which automatically simulates events in a normal operating scenario and low impedance faults in distribution systems that include unconventional renewable sources. During the development of this project, we were careful to comply with the standards (IEC 60909, ANSI / IEEE 141-4, IEEE 399) and contemplated engineering restrictions. For example, economic constraints ensuring the project was low budget; environmental restrictions considering that this project contributes to the reduction of greenhouse gases and technology through the implementation of information technology. The process of experimental validation of the operation of the tool was carried out by implementing the IEEE 34 nodes and IEEE 123 nodes systems. Case studies were developed in both systems by creating an event and comparing the manual results with the computational tool results. In conclusion, it was shown that the SEM tool fulfilled the objective of simulating and enriching the database of normal operation scenarios and under fault conditions for the study of microgrids. The impacts of the tool are technological because it is a very important tool for the design of microgrid protections, specifically those that have unconventional energy sources; economic because the production cost of the prototype is lower than that of other software with the same characteristics.
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- 2021
22. Colaboradores
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Acosta Acero, Marcy Viviana, Acuña Vesga, María Fernanda, Alvarán Mejía, Melissa, Álvarez Guachichulca, Javier Santiago, Álvarez Osorio, Leonardo, Álvarez-Cofiño Tuñón, Almudena, Amaya Romero, Nathaly, Andrade Rivas, María Leonor, David Arias, Juan, Arias Gómez, Alejandro, Aucapiña Calle, Cristina Soledad, Ávalos Gaxiola, Guillermo, Bautista Torres, Ana Milena, Cabarcas Solano, María, Cárdenas Angelone, Pedro Luis, Carrillo Rodríguez, Juan Sebastián, Castañeda Díez, Rafael, Castaño Parra, Andrés, Castellanos Prada, Leonardo, Chávez Díaz, Ricardo Manuel, Chávez Gutiérrez, Karla Gabriela, Chávez Gutiérrez, Ricardo Daniel, Chourio Ortiz, Eladio, Córdova López, Patricio F., Cuadros Segovia, Marco, Dávalos Feret, Andrea Paola, Juan de la Torre Estremadoyro, Mario Danilo, de Vera Gutiérrez, Jorge Luis, Díaz Carrasco, Andrés, Echeverría Vargas, Juan Antonio, Carlos Escaf, Luis, Escobar Gómez, Héctor Darío, Espinosa Encalada, Denisse, Espinoza García, Gustavo Adolfo, Estrada Uribe, Juliana, Fernández Engroba, Jorge, Fernández Vila, Pedro, Fernández-Vega González, Álvaro, Fernández-Vega Sanz, Álvaro, Forero, Lizeth, Fuquen Rojas, Johanna Patricia, Garcés Palacios, Manuel, García Loza, Brenda Alegría, García Medina, Karen Analí, García Mendoza, Betzabeth, Garzón Menjura, Angie Valentina, Giraldo Hoyos, John Mauricio, González Garrido, María Ángeles, González Martínez, Natalia, Ibares Frías, Lucía, Idrovo Calle, María Daniela, Iglesias Martínez, Katherine, Iturralde, Juan, Jácome Morejón, David Mateo, Jalil Florencia, Alejandro, Jalil Morante, Emilio, Jiménez Román, Jesús, Karam Aguilar, Emely Zoraida, Lazcano Gómez, Gabriel, Llantada Soto, Fátima Eleonora, Maldonado, Ramiro, Manríquez Salazar, María Paz, Marroquín Gómez, Guillermo, Martínez, Dayron, Martínez Malo, Luz Catherine, Mateos Oropeza, Rodrigo, Mejía Vergara, Álvaro José, Meza, Katherinne, Miotto Montesinos, Giuseppe, Miro-Quesada Woll, Juan José, Muci Mendoza, Rafael, Muñoz Cardona, Marta Lucía, Muñoz Flores, Tatiana, Nadal Reus, Jeroni, Newball Henry, Lyle, Ordóñez Mancheno, José Marcelo, Orozco García, Andrea, Ortega Figueroa, Jessica, Ortiz Farfán, Iván Teodoro, Ortiz Zapata, Álvaro Iván, Ortiz Zapata, Jacobo, Paczka Zapata, José Antonio, Camilo Parra, Juan, Peña Suárez, Jorge, Peralta Álvarez, Marcela, Pérez Rueda, Mario Alberto, Marcela Pineda, Lina, Pólit Macías, Mario, Pólit Manríquez, María Paz, Porras Zamora, Katherine Daniela, Prada Rocha, Angélica María, Rangel Gualdrón, Carlos Mario, Rodas Serrano, Agustín Esteban, Rodríguez Nieto, Harold Alexander, Rodríguez Pérez, José Manuel, Rodríguez Uña, Ignacio, Rojas Álvarez, Eduardo, Rojo Arnao, María, Roldán Vásquez, Ana María, De León, Laura Romero, Rueda Galvis, Juan Carlos, Rueda Latorre, Daniela, Saiz Ayala, Antonio, Sales Sanz, Marco, Sánchez Reyes, Walter, Sánchez Uzcátegui, Mary Alejandra, Sarrazín, Luis, Carlos Serrano, Juan, Tornero Jiménez, Andrea, Translateur Grynspan, Amir, Valarezo Macías, Paúl Alfonso, Vargas, Laura, Vásquez García, Ana María, Vázquez Ortiz, Emmanuel, Vélez Cevallos, María Alejandra, Villagómez Tirado, Germán, Villamizar, Jorge, Viteri Solorzano, Eduardo, Viver Oller, Sonia, Won Kim, Hae-Ryung, Wong Cam, Carlos, Wong Morales, Carlos, Zapata Díaz, Gloria Leonor, and Zaquinaula Iñahuazo, Elvis Bryan
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- 2024
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23. Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
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Cossarizza, Andrea, primary, Chang, Hyun‐Dong, additional, Radbruch, Andreas, additional, Abrignani, Sergio, additional, Addo, Richard, additional, Akdis, Mübeccel, additional, Andrä, Immanuel, additional, Andreata, Francesco, additional, Annunziato, Francesco, additional, Arranz, Eduardo, additional, Bacher, Petra, additional, Bari, Sudipto, additional, Barnaba, Vincenzo, additional, Barros‐Martins, Joana, additional, Baumjohann, Dirk, additional, Beccaria, Cristian G., additional, Bernardo, David, additional, Boardman, Dominic A., additional, Borger, Jessica, additional, Böttcher, Chotima, additional, Brockmann, Leonie, additional, Burns, Marie, additional, Busch, Dirk H., additional, Cameron, Garth, additional, Cammarata, Ilenia, additional, Cassotta, Antonino, additional, Chang, Yinshui, additional, Chirdo, Fernando Gabriel, additional, Christakou, Eleni, additional, Čičin‐Šain, Luka, additional, Cook, Laura, additional, Corbett, Alexandra J., additional, Cornelis, Rebecca, additional, Cosmi, Lorenzo, additional, Davey, Martin S., additional, De Biasi, Sara, additional, De Simone, Gabriele, additional, del Zotto, Genny, additional, Delacher, Michael, additional, Di Rosa, Francesca, additional, Di Santo, James, additional, Diefenbach, Andreas, additional, Dong, Jun, additional, Dörner, Thomas, additional, Dress, Regine J., additional, Dutertre, Charles‐Antoine, additional, Eckle, Sidonia B. G., additional, Eede, Pascale, additional, Evrard, Maximilien, additional, Falk, Christine S., additional, Feuerer, Markus, additional, Fillatreau, Simon, additional, Fiz‐Lopez, Aida, additional, Follo, Marie, additional, Foulds, Gemma A., additional, Fröbel, Julia, additional, Gagliani, Nicola, additional, Galletti, Giovanni, additional, Gangaev, Anastasia, additional, Garbi, Natalio, additional, Garrote, José Antonio, additional, Geginat, Jens, additional, Gherardin, Nicholas A., additional, Gibellini, Lara, additional, Ginhoux, Florent, additional, Godfrey, Dale I., additional, Gruarin, Paola, additional, Haftmann, Claudia, additional, Hansmann, Leo, additional, Harpur, Christopher M., additional, Hayday, Adrian C., additional, Heine, Guido, additional, Hernández, Daniela Carolina, additional, Herrmann, Martin, additional, Hoelsken, Oliver, additional, Huang, Qing, additional, Huber, Samuel, additional, Huber, Johanna E., additional, Huehn, Jochen, additional, Hundemer, Michael, additional, Hwang, William Y. K., additional, Iannacone, Matteo, additional, Ivison, Sabine M., additional, Jäck, Hans‐Martin, additional, Jani, Peter K., additional, Keller, Baerbel, additional, Kessler, Nina, additional, Ketelaars, Steven, additional, Knop, Laura, additional, Knopf, Jasmin, additional, Koay, Hui‐Fern, additional, Kobow, Katja, additional, Kriegsmann, Katharina, additional, Kristyanto, H., additional, Krueger, Andreas, additional, Kuehne, Jenny F., additional, Kunze‐Schumacher, Heike, additional, Kvistborg, Pia, additional, Kwok, Immanuel, additional, Latorre, Daniela, additional, Lenz, Daniel, additional, Levings, Megan K., additional, Lino, Andreia C., additional, Liotta, Francesco, additional, Long, Heather M., additional, Lugli, Enrico, additional, MacDonald, Katherine N., additional, Maggi, Laura, additional, Maini, Mala K., additional, Mair, Florian, additional, Manta, Calin, additional, Manz, Rudolf Armin, additional, Mashreghi, Mir‐Farzin, additional, Mazzoni, Alessio, additional, McCluskey, James, additional, Mei, Henrik E., additional, Melchers, Fritz, additional, Melzer, Susanne, additional, Mielenz, Dirk, additional, Monin, Leticia, additional, Moretta, Lorenzo, additional, Multhoff, Gabriele, additional, Muñoz, Luis Enrique, additional, Muñoz‐Ruiz, Miguel, additional, Muscate, Franziska, additional, Natalini, Ambra, additional, Neumann, Katrin, additional, Ng, Lai Guan, additional, Niedobitek, Antonia, additional, Niemz, Jana, additional, Almeida, Larissa Nogueira, additional, Notarbartolo, Samuele, additional, Ostendorf, Lennard, additional, Pallett, Laura J., additional, Patel, Amit A., additional, Percin, Gulce Itir, additional, Peruzzi, Giovanna, additional, Pinti, Marcello, additional, Pockley, A. Graham, additional, Pracht, Katharina, additional, Prinz, Immo, additional, Pujol‐Autonell, Irma, additional, Pulvirenti, Nadia, additional, Quatrini, Linda, additional, Quinn, Kylie M., additional, Radbruch, Helena, additional, Rhys, Hefin, additional, Rodrigo, Maria B., additional, Romagnani, Chiara, additional, Saggau, Carina, additional, Sakaguchi, Shimon, additional, Sallusto, Federica, additional, Sanderink, Lieke, additional, Sandrock, Inga, additional, Schauer, Christine, additional, Scheffold, Alexander, additional, Scherer, Hans U., additional, Schiemann, Matthias, additional, Schildberg, Frank A., additional, Schober, Kilian, additional, Schoen, Janina, additional, Schuh, Wolfgang, additional, Schüler, Thomas, additional, Schulz, Axel R., additional, Schulz, Sebastian, additional, Schulze, Julia, additional, Simonetti, Sonia, additional, Singh, Jeeshan, additional, Sitnik, Katarzyna M., additional, Stark, Regina, additional, Starossom, Sarah, additional, Stehle, Christina, additional, Szelinski, Franziska, additional, Tan, Leonard, additional, Tarnok, Attila, additional, Tornack, Julia, additional, Tree, Timothy I. M., additional, van Beek, Jasper J. P., additional, van de Veen, Willem, additional, van Gisbergen, Klaas, additional, Vasco, Chiara, additional, Verheyden, Nikita A., additional, von Borstel, Anouk, additional, Ward‐Hartstonge, Kirsten A., additional, Warnatz, Klaus, additional, Waskow, Claudia, additional, Wiedemann, Annika, additional, Wilharm, Anneke, additional, Wing, James, additional, Wirz, Oliver, additional, Wittner, Jens, additional, Yang, Jennie H. M., additional, and Yang, Juhao, additional
- Published
- 2021
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24. IMMUNODEFICIENCIES: Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations
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Okada, Satoshi, Markle, Janet G., Deenick, Elissa K., Mele, Federico, Averbuch, Dina, Lagos, Macarena, Alzahrani, Mohammed, Al-Muhsen, Saleh, Halwani, Rabih, Ma, Cindy S., Wong, Natalie, Soudais, Claire, Henderson, Lauren A., Marzouqa, Hiyam, Shamma, Jamal, Gonzalez, Marcela, Martinez-Barricarte, Rubén, Okada, Chizuru, Avery, Danielle T., Latorre, Daniela, Deswarte, Caroline, Jabot-Hanin, Fabienne, Torrado, Egidio, Fountain, Jeffrey, Belkadi, Aziz, Itan, Yuval, Boisson, Bertrand, Migaud, Mélanie, Lindestam Arlehamn, Cecilia S., Sette, Alessandro, Breton, Sylvain, McCluskey, James, Rossjohn, Jamie, Villartay, Jean-Pierre de, Moshous, Despina, Hambleton, Sophie, Latour, Sylvain, Arkwright, Peter D., Picard, Capucine, Lantz, Olivier, Engelhard, Dan, Kobayashi, Masao, Abel, Laurent, Cooper, Andrea M., Notarangelo, Luigi D., Boisson-Dupuis, Stéphanie, Puel, Anne, Sallusto, Federica, Bustamante, Jacinta, Tangye, Stuart G., and Casanova, Jean-Laurent
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- 2015
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25. T CELL IMMUNITY: Functional heterogeneity of human memory CD4+ T cell clones primed by pathogens or vaccines
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Becattini, Simone, Latorre, Daniela, Mele, Federico, Foglierini, Mathilde, De Gregorio, Corinne, Cassotta, Antonino, Fernandez, Blanca, Kelderman, Sander, Schumacher, Ton N., Corti, Davide, Lanzavecchia, Antonio, and Sallusto, Federica
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- 2015
- Full Text
- View/download PDF
26. Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
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Rolf M. Schwiete Foundation, Associazione Italiana per la Ricerca sul Cancro, German Research Foundation, National Institutes of Health (US), European Commission, Cossarizza, Andrea, Chang, Hyun‐Dong, Radbruch, Andreas, Abrignani, Sergio, Addo, Richard, Akdis, Mübeccel, Andrä, Immanuel, Andreata, Francesco, Annunziato, Francesco, Arranz, Eduardo, Bacher, Petra, Knop, Laura, Knopf, Jasmin, Koay, Hui-Fern, Kobow, Katja, Kriegsmann, Katharina, Kristyanto, H., Krueger, Andreas, Kuehne, Jenny F., Kunze-Schumacher, Heike, Maini, Mala K., Verheyden, Nikita A., Kvistborg, Pia, Kwok, Immanuel, Latorre, Daniela, Mair, Florian, Bari, Sudipto, Manta, Calin, Armin Manz, Rudolf, Mashreghi, Mir-Farzin, Mazzoni, Alessio, McCluskey, James, Borstel, Anouk von, Mei, Henrik E., Melchers, Fritz, Melzer, Susanne, Mielenz, Dirk, Monin, Leticia, Barnaba, Vincenzo, Moretta, Lorenzo, Multhoff, Gabriele, Muñoz, Luis Enrique, Muñoz-Ruiz, Miguel, Ward-Hartstonge, Kirsten A., Muscate, Franziska, Natalini, Ambra, Neumann, Katrin, Guan N., Lai, Niedobitek, Antonia, Niemz, Jana, Barros-Martins, Joana, Nogueira Almeida, Larissa, Notarbartolo, Samuele, Ostendorf, Lennard, Warnatz, Klaus, Pallett, Laura J., Patel, Amit A., Itir Percin, Gulce, Peruzzi, Giovanna, Pinti, Marcello, Pockley, A. Graham, Pracht, Katharina, Baumjohann, Dirk, Prinz, Immo, Pujol-Autonell, Irma, Waskow, Claudia, Pulvirenti, Nadia, Quatrini, Linda, Quinn, Kylie M., Radbruch, Helena, Rhys, Hefin, Rodrigo, Maria B., Romagnani, Chiara, Saggau, Carina, Beccaria, Cristian G., Sakaguchi, Shimon, Wiedemann, Annika, Sallusto, Federica, Sanderink, Lieke, Sandrock, Inga, Schauer, Christine, Scheffold, Alexander, Scherer, Hans U., Schiemann, Matthias, Schildberg, Frank A., Schober, Kilian, Bernardo, David, Wilharm, Anneke, Schoen, Janina, Schuh, Wolfgang, Schüler, Thomas, Schulz, Axel R., Schulz, Sebastian, Schulze, Julia, Simonetti, Sonia, Singh, Jeeshan, Sitnik, Katarzyna M., Stark, Regina, Wing, James, Boardman, Dominic A., Starossom, Sarah, Stehle, Christina, Szelinski, Franziska, Tan, Leonard, Tarnok, Attila, Tornack, Julia, Tree, Timothy I. M., Van Beek, Jasper J. P., Veen, Willem van de, Wirz, Oliver, Gisbergen, Klaas van, Borger, Jessica, Vasco, Chiara, Böttcher, Chotima, Lenz, Daniel, Wittner, Jens, Yang, Jennie H. M., Yang, Juhao, Brockmann, Leonie, Burns, Marie, Busch, Dirk H., Cameron, Garth, Cammarata, Ilenia, Cassotta, Antonino, Chang, Yinshui, Levings, Megan K., Chirdo, Fernando G., Christakou, Eleni, Cicin-Sain, Luka, Cook, Laura, Corbett, Alexandra J., Cornelis, Rebecca, Cosmi, Lorenzo, Davey, Martin S., Biasi, Sara De, Simone, Gabriele De, Lino, Andreia C., Zotto, Genny del, Delacher, Michael, Rosa, Francesca Di, Santo, James Di, Diefenbach, Andreas, Dong, Jun, Dörner, Thomas, Dress, Regine J., Dutertre, Charles-Antoine, Eckle, Sidonia B. G., Liotta, Francesco, Eede, Pascale, Evrard, Maximilien, Falk, Christine S., Feuerer, Markus, Fillatreau, Simon, Fiz-López, Aida, Follo, Marie, Foulds, Gemma A., Fröbel, Julia, Gagliani, Nicola, Long, Heather M., Galletti, Giovanni, Gangaev, Anastasia, Garbi, Natalio, Garrote, José Antonio, Geginat, Jens, Gherardin, Nicholas A., Gibellini, Lara, Ginhoux, Florent, Godfrey, Dale I., Gruarin, Paola, Lugli, Enrico, Haftmann, Claudia, Hansmann, Leo, Harpur, Christopher M., Hayday, Adrian C., Heine, Guido, Hernández, Daniela Carolina, Herrmann, Martin, Hoelsken, Oliver, Huang, Qing, Huber, Samuel, MacDonald, Katherine N., Huber, Johanna E., Huehn, Jochen, Hundemer, Michael, Hwang, William Y. K., Iannacone, Matteo, Ivison, Sabine M., Jäck, Hans-Martin, Jani, Peter K., Keller, Baerbel, Kessler, Nina, Maggi, Laura, Ketelaars, Steven, Rolf M. Schwiete Foundation, Associazione Italiana per la Ricerca sul Cancro, German Research Foundation, National Institutes of Health (US), European Commission, Cossarizza, Andrea, Chang, Hyun‐Dong, Radbruch, Andreas, Abrignani, Sergio, Addo, Richard, Akdis, Mübeccel, Andrä, Immanuel, Andreata, Francesco, Annunziato, Francesco, Arranz, Eduardo, Bacher, Petra, Knop, Laura, Knopf, Jasmin, Koay, Hui-Fern, Kobow, Katja, Kriegsmann, Katharina, Kristyanto, H., Krueger, Andreas, Kuehne, Jenny F., Kunze-Schumacher, Heike, Maini, Mala K., Verheyden, Nikita A., Kvistborg, Pia, Kwok, Immanuel, Latorre, Daniela, Mair, Florian, Bari, Sudipto, Manta, Calin, Armin Manz, Rudolf, Mashreghi, Mir-Farzin, Mazzoni, Alessio, McCluskey, James, Borstel, Anouk von, Mei, Henrik E., Melchers, Fritz, Melzer, Susanne, Mielenz, Dirk, Monin, Leticia, Barnaba, Vincenzo, Moretta, Lorenzo, Multhoff, Gabriele, Muñoz, Luis Enrique, Muñoz-Ruiz, Miguel, Ward-Hartstonge, Kirsten A., Muscate, Franziska, Natalini, Ambra, Neumann, Katrin, Guan N., Lai, Niedobitek, Antonia, Niemz, Jana, Barros-Martins, Joana, Nogueira Almeida, Larissa, Notarbartolo, Samuele, Ostendorf, Lennard, Warnatz, Klaus, Pallett, Laura J., Patel, Amit A., Itir Percin, Gulce, Peruzzi, Giovanna, Pinti, Marcello, Pockley, A. Graham, Pracht, Katharina, Baumjohann, Dirk, Prinz, Immo, Pujol-Autonell, Irma, Waskow, Claudia, Pulvirenti, Nadia, Quatrini, Linda, Quinn, Kylie M., Radbruch, Helena, Rhys, Hefin, Rodrigo, Maria B., Romagnani, Chiara, Saggau, Carina, Beccaria, Cristian G., Sakaguchi, Shimon, Wiedemann, Annika, Sallusto, Federica, Sanderink, Lieke, Sandrock, Inga, Schauer, Christine, Scheffold, Alexander, Scherer, Hans U., Schiemann, Matthias, Schildberg, Frank A., Schober, Kilian, Bernardo, David, Wilharm, Anneke, Schoen, Janina, Schuh, Wolfgang, Schüler, Thomas, Schulz, Axel R., Schulz, Sebastian, Schulze, Julia, Simonetti, Sonia, Singh, Jeeshan, Sitnik, Katarzyna M., Stark, Regina, Wing, James, Boardman, Dominic A., Starossom, Sarah, Stehle, Christina, Szelinski, Franziska, Tan, Leonard, Tarnok, Attila, Tornack, Julia, Tree, Timothy I. M., Van Beek, Jasper J. P., Veen, Willem van de, Wirz, Oliver, Gisbergen, Klaas van, Borger, Jessica, Vasco, Chiara, Böttcher, Chotima, Lenz, Daniel, Wittner, Jens, Yang, Jennie H. M., Yang, Juhao, Brockmann, Leonie, Burns, Marie, Busch, Dirk H., Cameron, Garth, Cammarata, Ilenia, Cassotta, Antonino, Chang, Yinshui, Levings, Megan K., Chirdo, Fernando G., Christakou, Eleni, Cicin-Sain, Luka, Cook, Laura, Corbett, Alexandra J., Cornelis, Rebecca, Cosmi, Lorenzo, Davey, Martin S., Biasi, Sara De, Simone, Gabriele De, Lino, Andreia C., Zotto, Genny del, Delacher, Michael, Rosa, Francesca Di, Santo, James Di, Diefenbach, Andreas, Dong, Jun, Dörner, Thomas, Dress, Regine J., Dutertre, Charles-Antoine, Eckle, Sidonia B. G., Liotta, Francesco, Eede, Pascale, Evrard, Maximilien, Falk, Christine S., Feuerer, Markus, Fillatreau, Simon, Fiz-López, Aida, Follo, Marie, Foulds, Gemma A., Fröbel, Julia, Gagliani, Nicola, Long, Heather M., Galletti, Giovanni, Gangaev, Anastasia, Garbi, Natalio, Garrote, José Antonio, Geginat, Jens, Gherardin, Nicholas A., Gibellini, Lara, Ginhoux, Florent, Godfrey, Dale I., Gruarin, Paola, Lugli, Enrico, Haftmann, Claudia, Hansmann, Leo, Harpur, Christopher M., Hayday, Adrian C., Heine, Guido, Hernández, Daniela Carolina, Herrmann, Martin, Hoelsken, Oliver, Huang, Qing, Huber, Samuel, MacDonald, Katherine N., Huber, Johanna E., Huehn, Jochen, Hundemer, Michael, Hwang, William Y. K., Iannacone, Matteo, Ivison, Sabine M., Jäck, Hans-Martin, Jani, Peter K., Keller, Baerbel, Kessler, Nina, Maggi, Laura, and Ketelaars, Steven
- Abstract
The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive sections describing phenotypes and functional assays of all major human and murine immune cell subsets. Notably, the Guidelines contain helpful tables highlighting phenotypes and key differences between human and murine cells. Another useful feature of this edition is the flow cytometry analysis of clinical samples with examples of flow cytometry applications in the context of autoimmune diseases, cancers as well as acute and chronic infectious diseases. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid. All sections are written and peer-reviewed by leading flow cytometry experts and immunologists, making this edition an essential and state-of-the-art handbook for basic and clinical researchers.
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- 2021
27. The Swiss Primary Hypersomnolence and Narcolepsy Cohort study (SPHYNCS): Study protocol for a prospective, multicentre cohort observational study
- Author
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Dietmann, Anelia; https://orcid.org/0000-0002-8949-0645, Wenz, Elena; https://orcid.org/0000-0002-6231-3358, van der Meer, Julia; https://orcid.org/0000-0002-1913-5146, Ringli, Maya, Warncke, Jan D; https://orcid.org/0000-0001-6852-4191, Edwards, Ellen; https://orcid.org/0000-0003-1986-1831, Schmidt, Markus H; https://orcid.org/0000-0002-3299-1318, Bernasconi, Corrado A; https://orcid.org/0000-0002-1019-5468, Nirkko, Arto, Strub, Mathias, Miano, Silvia; https://orcid.org/0000-0003-4475-3947, Manconi, Mauro; https://orcid.org/0000-0002-1849-7196, Acker, Jens; https://orcid.org/0000-0002-5875-656X, von Manitius, Sigrid, Baumann, Christian R; https://orcid.org/0000-0003-3417-1978, Valko, Philip O; https://orcid.org/0000-0002-8435-1697, Yilmaz, Bahtiyar; https://orcid.org/0000-0003-1888-9226, Brunner, Andreas-David; https://orcid.org/0000-0002-2733-7899, Tzovara, Athina; https://orcid.org/0000-0002-7588-1418, Zhang, Zhongxing; https://orcid.org/0000-0003-0184-8882, Largiadèr, Carlo R; https://orcid.org/0000-0002-0889-8922, Tafti, Mehdi; https://orcid.org/0000-0002-6997-3914, Latorre, Daniela; https://orcid.org/0000-0003-1031-1534, Sallusto, Federica; https://orcid.org/0000-0003-3750-2752, Khatami, Ramin, Bassetti, Claudio L A; https://orcid.org/0000-0002-4535-0245, Dietmann, Anelia; https://orcid.org/0000-0002-8949-0645, Wenz, Elena; https://orcid.org/0000-0002-6231-3358, van der Meer, Julia; https://orcid.org/0000-0002-1913-5146, Ringli, Maya, Warncke, Jan D; https://orcid.org/0000-0001-6852-4191, Edwards, Ellen; https://orcid.org/0000-0003-1986-1831, Schmidt, Markus H; https://orcid.org/0000-0002-3299-1318, Bernasconi, Corrado A; https://orcid.org/0000-0002-1019-5468, Nirkko, Arto, Strub, Mathias, Miano, Silvia; https://orcid.org/0000-0003-4475-3947, Manconi, Mauro; https://orcid.org/0000-0002-1849-7196, Acker, Jens; https://orcid.org/0000-0002-5875-656X, von Manitius, Sigrid, Baumann, Christian R; https://orcid.org/0000-0003-3417-1978, Valko, Philip O; https://orcid.org/0000-0002-8435-1697, Yilmaz, Bahtiyar; https://orcid.org/0000-0003-1888-9226, Brunner, Andreas-David; https://orcid.org/0000-0002-2733-7899, Tzovara, Athina; https://orcid.org/0000-0002-7588-1418, Zhang, Zhongxing; https://orcid.org/0000-0003-0184-8882, Largiadèr, Carlo R; https://orcid.org/0000-0002-0889-8922, Tafti, Mehdi; https://orcid.org/0000-0002-6997-3914, Latorre, Daniela; https://orcid.org/0000-0003-1031-1534, Sallusto, Federica; https://orcid.org/0000-0003-3750-2752, Khatami, Ramin, and Bassetti, Claudio L A; https://orcid.org/0000-0002-4535-0245
- Abstract
Narcolepsy type 1 (NT1) is a disorder with well-established markers and a suspected autoimmune aetiology. Conversely, the narcoleptic borderland (NBL) disorders, including narcolepsy type 2, idiopathic hypersomnia, insufficient sleep syndrome and hypersomnia associated with a psychiatric disorder, lack well-defined markers and remain controversial in terms of aetiology, diagnosis and management. The Swiss Primary Hypersomnolence and Narcolepsy Cohort Study (SPHYNCS) is a comprehensive multicentre cohort study, which will investigate the clinical picture, pathophysiology and long-term course of NT1 and the NBL. The primary aim is to validate new and reappraise well-known markers for the characterization of the NBL, facilitating the diagnostic process. Seven Swiss sleep centres, belonging to the Swiss Narcolepsy Network (SNaNe), joined the study and will prospectively enrol over 500 patients with recent onset of excessive daytime sleepiness (EDS), hypersomnia or a suspected central disorder of hypersomnolence (CDH) during a 3-year recruitment phase. Healthy controls and patients with EDS due to severe sleep-disordered breathing, improving after therapy, will represent two control groups of over 50 patients each. Clinical and electrophysiological (polysomnography, multiple sleep latency test, maintenance of wakefulness test) information, and information on psychomotor vigilance and a sustained attention to response task, actigraphy and wearable devices (long-term monitoring), and responses to questionnaires will be collected at baseline and after 6, 12, 24 and 36 months. Potential disease markers will be searched for in blood, cerebrospinal fluid and stool. Analyses will include quantitative hypocretin measurements, proteomics/peptidomics, and immunological, genetic and microbiota studies. SPHYNCS will increase our understanding of CDH and the relationship between NT1 and the NBL. The identification of new disease markers is expected to lead to better and earlier diagn
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- 2021
28. LF immunomodulatory strategies: mastering bacterial endotoxin
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Latorre, Daniela, Berlutti, Francesca, Valenti, Piera, Gessani, Sandra, and Puddu, Patrizia
- Subjects
Immunology -- Research ,Endotoxins -- Health aspects -- Physiological aspects ,Lactoferrins -- Health aspects -- Physiological aspects ,Biological sciences - Abstract
Lactoferrin (LF), an iron-binding glycoprotein expressed in most biological fluids, represents a major component of mammalian innate immune system. The multiple activities of LF rely not only on its capacity to bind iron but also to interact with molecular and cellular components of both the host and pathogens. LF can bind and sequester lipopolysaccharide thus preventing proinflammatory pathway activation, sepsis, and tissue damage. However, the interplay between LF and lipopolysaccharide is complex and may lead to different outcomes including both the suppression of inflammatory response and immune activation. Understanding the molecular basis and the functional consequences of this complex interaction is critically relevant in the development of LF-based therapeutic interventions in humans. Key words: lactoferrin, lipopolysaccharide, inflammation, immune response. La lactoferrine (LF), une glycoproteine liant le fer presente dans la plupart des liquides biologiques, constitue une composante majeure du systeme immunitaire inne chez les mammiferes. Les nombreuses activites de la LF dependent non seulement de sa capacite a lier le fer mais aussi de ses interactions avec des composantes moleculaires et cellulaires des hotes et des pathogenes. La LF peut lier et sequestrer le lipopolysaccharide (LPS), prevenant ainsi l'activation de voies pro-inflammatoires, la sepsie et le dommage tissulaire. Cependant, l'interaction entre la LF et le LPS est complexe et peut mener a des resultats differents, incluant autant la suppression de la reponse inflammatoire que l'activation immunitaire. La comprehension des bases moleculaires et des consequences fonctionnelles de cette interaction complexe est capitale au developpement d' interventions therapeutiques a base de LF chez l' humain. Mots-cles : lactoferrine, lipopolysaccharide, inflammation, reponse immunitaire., Lactoferrin biological activities in host defence Lactoferrin (LF) plays a key role in maintaining cellular iron levels in the body, a function common to all transferrins. However, its structural features [...]
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- 2012
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29. Immunoregulatory role of lactoferrin-lipopolysaccharide interactions
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Puddu, Patrizia, Latorre, Daniela, Valenti, Piera, and Gessani, Sandra
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- 2010
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30. The immunopathogenesis of narcolepsy type 1
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Liblau, Roland S., Latorre, Daniela, Kornum, Birgitte R., Dauvilliers, Yves, and Mignot, Emmanuel J.
- Abstract
Narcolepsy type 1 (NT1) is a chronic sleep disorder resulting from the loss of a small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; also known as orexin) peptides. An immune-mediated pathology for NT1 has long been suspected given its exceptionally tight association with the MHC class II allele HLA-DQB1*06:02, as well as recent genetic evidence showing associations with polymorphisms of T cell receptor genes and other immune-relevant loci and the increased incidence of NT1 that has been observed after vaccination with the influenza vaccine Pandemrix. The search for both self-antigens and foreign antigens recognized by the pathogenic T cell response in NT1 is ongoing. Increased T cell reactivity against HCRT has been consistently reported in patients with NT1, but data demonstrating a primary role for T cells in neuronal destruction are currently lacking. Animal models are providing clues regarding the roles of autoreactive CD4+and CD8+T cells in the disease. Elucidation of the pathogenesis of NT1 will allow for the development of targeted immunotherapies at disease onset and could serve as a model for other immune-mediated neurological diseases.
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- 2023
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31. The Swiss Primary Hypersomnolence and Narcolepsy Cohort study (SPHYNCS): Study protocol for a prospective, multicentre cohort observational study
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Dietmann, Anelia, primary, Wenz, Elena, additional, Meer, Julia, additional, Ringli, Maya, additional, Warncke, Jan D., additional, Edwards, Ellen, additional, Schmidt, Markus H., additional, Bernasconi, Corrado A., additional, Nirkko, Arto, additional, Strub, Mathias, additional, Miano, Silvia, additional, Manconi, Mauro, additional, Acker, Jens, additional, Manitius, Sigrid, additional, Baumann, Christian R., additional, Valko, Philip O., additional, Yilmaz, Bahtiyar, additional, Brunner, Andreas‐David, additional, Tzovara, Athina, additional, Zhang, Zhongxing, additional, Largiadèr, Carlo R., additional, Tafti, Mehdi, additional, Latorre, Daniela, additional, Sallusto, Federica, additional, Khatami, Ramin, additional, and Bassetti, Claudio L. A., additional
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- 2021
- Full Text
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32. Automated corneal endothelium image segmentation in the presence of cornea guttata via convolutional neural networks - 115110H
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Sierra Bravo, Juan Sebastián, Pineda, Jesús, Viteri Coronel, Eduardo, Rueda Latorre, Daniela, Tibaduiza Vargas, Beatriz Eugenia, Berrospi, Rubén, Tello, Alejandro, Galvis Ramírez, Virgilio, Volpe, Giovanni, Millán Garcia-Varela, M. Sagrario, Romero Pérez, Lenny Alexandra, Marrugo Hernandez, Andrés Guillermo, Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria, and Universitat Politècnica de Catalunya. GOAPI - Grup d'Òptica Aplicada i Processament d'Imatge
- Subjects
Microscopy ,Corneal endothelium ,Convolutional neural network ,Medical image segmentation ,Endoteli ,eye diseases ,U-net ,Cornea ,Cornea guttata ,Microscòpia ,Specular microscopy ,Imatgeria mèdica ,Ciències de la visió [Àrees temàtiques de la UPC] ,sense organs ,Endothelium ,Imaging systems in medicine ,Còrnia - Abstract
Automated cell counting in in-vivo specular microscopy images is challenging, especially in situations where single-cell segmentation methods fail due to pathological conditions. This work aims to obtain reliable cell segmentation from specular microscopy images of both healthy and pathological corneas. We cast the problem of cell segmentation as a supervised multi-class segmentation problem. The goal is to learn a mapping relation between an input specular microscopy image and its labeled counterpart, indicating healthy (cells) and pathological regions (e.g., guttae). We trained a U-net model by extracting 96 96 pixel patches from corneal endothelial cell images and the corresponding manual segmentation by a physician. Encouraging results show that the proposed method can deliver reliable feature segmentation enabling more accurate cell density estimations for assessing the state of the cornea. This work has been partly funded by the Centre de Cooperació i Desenvolupament (CCD) at the Universitat Politècnica de Catalunya under project ref. CCD 2020-B014.
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- 2020
33. Automated corneal endothelium image segmentation in the presence of cornea guttata via convolutional neural networks - 115110H
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Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria, Universitat Politècnica de Catalunya. GOAPI - Grup d'Òptica Aplicada i Processament d'Imatge, Sierra Bravo, Juan Sebastián, Pineda, Jesús, Viteri Coronel, Eduardo, Rueda Latorre, Daniela, Tibaduiza Vargas, Beatriz Eugenia, Berrospi, Rubén, Tello, Alejandro, Galvis Ramírez, Virgilio, Volpe, Giovanni, Millán Garcia-Varela, M. Sagrario, Romero Pérez, Lenny Alexandra, Marrugo Hernandez, Andrés Guillermo, Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria, Universitat Politècnica de Catalunya. GOAPI - Grup d'Òptica Aplicada i Processament d'Imatge, Sierra Bravo, Juan Sebastián, Pineda, Jesús, Viteri Coronel, Eduardo, Rueda Latorre, Daniela, Tibaduiza Vargas, Beatriz Eugenia, Berrospi, Rubén, Tello, Alejandro, Galvis Ramírez, Virgilio, Volpe, Giovanni, Millán Garcia-Varela, M. Sagrario, Romero Pérez, Lenny Alexandra, and Marrugo Hernandez, Andrés Guillermo
- Abstract
Automated cell counting in in-vivo specular microscopy images is challenging, especially in situations where single-cell segmentation methods fail due to pathological conditions. This work aims to obtain reliable cell segmentation from specular microscopy images of both healthy and pathological corneas. We cast the problem of cell segmentation as a supervised multi-class segmentation problem. The goal is to learn a mapping relation between an input specular microscopy image and its labeled counterpart, indicating healthy (cells) and pathological regions (e.g., guttae). We trained a U-net model by extracting 96 96 pixel patches from corneal endothelial cell images and the corresponding manual segmentation by a physician. Encouraging results show that the proposed method can deliver reliable feature segmentation enabling more accurate cell density estimations for assessing the state of the cornea., This work has been partly funded by the Centre de Cooperació i Desenvolupament (CCD) at the Universitat Politècnica de Catalunya under project ref. CCD 2020-B014., Peer Reviewed, Postprint (published version)
- Published
- 2020
34. Bovine lactoferrin-induced CCL1 expression involves distinct receptors in monocyte-derived dendritic cells and their monocyte precursors
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Latorre, Daniela, Pulvirenti, Nadia, Covino, Daniela Angela, Varano, Barbara, Purificato, Cristina, Rainaldi, Gabriella, Gauzzi, Maria Cristina, Fantuzzi, Laura, Conti, Lucia, Donninelli, Gloria, Del Cornò, Manuela, Sabbatucci, Michela, Gessani, Sandra, Puddu, Patrizia, Latorre, Daniela, Pulvirenti, Nadia, Covino, Daniela Angela, Varano, Barbara, Purificato, Cristina, Rainaldi, Gabriella, Gauzzi, Maria Cristina, Fantuzzi, Laura, Conti, Lucia, Donninelli, Gloria, Del Cornò, Manuela, Sabbatucci, Michela, Gessani, Sandra, and Puddu, Patrizia
- Abstract
Lactoferrin (LF) exhibits a wide range of immunomodulatory activities including modulation of cytokine and chemokine secretion. In this study, we demonstrate that bovine LF (bLF) up-modulates, in a concentration- and time-dependent manner, CCL1 secretion in monocytes (Mo) at the early stage of differentiation toward dendritic cells (DCs), and in fully differentiated immature Mo-derived DCs (MoDCs). In both cell types, up-modulation of CCL1 secretion is an early event following bLF-mediated enhanced accumulation of CCL1 transcripts. Notably, bLF-mediated up-regulation of CCL1 involves the engagement of distinct surface receptors in MoDCs and their Mo precursors. We show that bLF-mediated engagement of CD36 contributes to CCL1 induction in differentiating Mo. Conversely, toll-like receptor (TLR)2 blocking markedly reduces bLF-induced CCL1 production in MoDCs. These findings add further evidence for cell-specific differential responses elicited by bLF through the engagement of distinct TLRs and surface receptor. Furthermore, the different responses observed at early and late stages of Mo differentiation towards DCs may be relevant in mediating bLF effects in specific body districts, where these cell types may be differently represented in physiopathological conditions.
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- 2020
35. How the Gut Microbiota Influences Our Health and How We Can Influence It
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Arnoldini, Markus, primary, Lentsch, Verena, additional, Latorre, Daniela, additional, Greter, Giorgia, additional, Slack, Emma, additional, Giorgetti, Ambra, additional, Groppo, Alessandro, additional, and Kha, Lilian, additional
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- 2021
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- View/download PDF
36. Broadly reactive human CD4 + T cells against Enterobacteriaceae are found in the naïve repertoire and are clonally expanded in the memory repertoire
- Author
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Cassotta, Antonino, primary, Goldstein, Jérémie D., additional, Durini, Greta, additional, Jarrossay, David, additional, Baggi Menozzi, Franca, additional, Venditti, Mario, additional, Russo, Alessandro, additional, Falcone, Marco, additional, Lanzavecchia, Antonio, additional, Gagliardi, Maria Cristina, additional, Latorre, Daniela, additional, and Sallusto, Federica, additional
- Published
- 2020
- Full Text
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37. Human T-bet governs innate and innate-like adaptive IFN-γ immunity against mycobacteria
- Author
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Yang, Rui, primary, Mele, Federico, additional, Worley, Lisa, additional, Langlais, David, additional, Rosain, Jérémie, additional, Benhsaien, Ibithal, additional, Elarabi, Houda, additional, Croft, Carys A., additional, Doisne, Jean-Marc, additional, Zhang, Peng, additional, Weisshaar, Marc, additional, Jarrossay, David, additional, Latorre, Daniela, additional, Shen, Yichao, additional, Han, Jing, additional, Gruber, Conor, additional, Markle, Janet, additional, Al Ali, Fatima, additional, Rahman, Mahbuba, additional, Khan, Taushif, additional, Seeleuthner, Yoann, additional, Kerner, Gaspard, additional, Husquin, Lucas T., additional, Maclsaac, Julia L., additional, Jeljeli, Mohamed, additional, Ailal, Fatima, additional, Kobor, Michael S., additional, Oleaga-Quintas, Carmen, additional, Roynard, Manon, additional, Bourgey, Mathieu, additional, El Baghdadi, Jamila, additional, Boisson-Dupuis, Stéphanie, additional, Puel, Anne, additional, Batteux, Fréderic, additional, Rozenberg, Flore, additional, Marr, Nico, additional, Pan-Hammarström, Qiang, additional, Bogunovic, Dusan, additional, Quintana-Murci, Lluis, additional, Carroll, Thomas, additional, Ma, Cindy S, additional, Abel, Laurent, additional, Bousfiha, Aziz, additional, Di Santo, James P., additional, Glimcher, Laurie H, additional, Gros, Philippe, additional, Tangye, Stuart G, additional, Sallusto, Federica, additional, Bustamante, Jacinta, additional, and Casanova, Jean-Laurent, additional
- Published
- 2020
- Full Text
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38. ERK phosphorylation and miR-181a expression modulate activation of human memory TH17 cells
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Mele, Federico, Basso, Camilla, Leoni, Cristina, Aschenbrenner, Dominik, Becattini, Simone, Latorre, Daniela, Lanzavecchia, Antonio, Sallusto, Federica, Monticelli, Silvia, Mele, Federico, Basso, Camilla, Leoni, Cristina, Aschenbrenner, Dominik, Becattini, Simone, Latorre, Daniela, Lanzavecchia, Antonio, Sallusto, Federica, and Monticelli, Silvia
- Abstract
T helper (TH) cell polarization during priming is modulated by a number of signals, but whether polarization to a given phenotype also influences recall responses of memory TH cells is relatively unknown. Here we show that miR-181a is selectively induced in both human and mouse naive T cells differentiating into the TH17, but not TH1 or TH2 subset. In human memory TH17 cells, miR-181a regulates responses to cognate antigens through modulation of ERK phosphorylation. By enhancing the signalling cascade from the T-cell receptor, such molecular network reduces the threshold of TH17 cell activation. Moreover, at a late time point, the same network induces a self-regulatory mechanism dependent on ID3, a negative regulator of transcription factors that control RORC expression, thus modulating TH17 activity. Our results demonstrate that the phenotype acquired by TH cells during priming contributes to their threshold of activation to secondary antigenic stimulations, thus influencing memory responses.
- Published
- 2019
39. Why Is Measles Vaccination So Important?
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Slack, Emma, primary, Arnoldini, Markus, additional, Latorre, Daniela, additional, Aslani, Selma, additional, Biagioli, Valentina, additional, Cruz, Tania, additional, Dünki, Naomi Elina, additional, Eichelberg, Antonia Chiara Jeanne, additional, Goldiger, Matthias, additional, Howald, Nicole, additional, Marastoni, Giovanni, additional, Marti, Thierry, additional, Peterhans, Vega, additional, Selvakumar, Lavanja, additional, and Winterberg, Anna, additional
- Published
- 2019
- Full Text
- View/download PDF
40. Broadly reactive human CD4+ T cells against Enterobacteriaceae are found in the naïve repertoire and are clonally expanded in the memory repertoire.
- Author
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Cassotta, Antonino, Goldstein, Jérémie D., Durini, Greta, Jarrossay, David, Baggi Menozzi, Franca, Venditti, Mario, Russo, Alessandro, Falcone, Marco, Lanzavecchia, Antonio, Gagliardi, Maria Cristina, Latorre, Daniela, and Sallusto, Federica
- Subjects
T cells ,ENTEROBACTERIACEAE ,NOSOCOMIAL infections ,GRAM-negative bacteria ,CLONE cells - Abstract
Enterobacteriaceae are a large family of Gram‐negative bacteria that includes both commensals and opportunistic pathogens. The latter can cause severe nosocomial infections, with outbreaks of multi‐antibiotics resistant strains, thus being a major public health threat. In this study, we report that Enterobacteriaceae‐reactive memory Th cells were highly enriched in a CCR6+CXCR3+ Th1*/17 cell subset and produced IFN‐γ, IL‐17A, and IL‐22. This T cell subset was severely reduced in septic patients with K. pneumoniae bloodstream infection who also selectively lacked circulating K. pneumonie‐reactive T cells. By combining heterologous antigenic stimulation, single cell cloning and TCR Vβ sequencing, we demonstrate that a large fraction of memory Th cell clones was broadly cross‐reactive to several Enterobacteriaceae species. These cross‐reactive Th cell clones were expanded in vivo and a large fraction of them recognized the conserved outer membrane protein A antigen. Interestingly, Enterobacteriaceae broadly cross‐reactive T cells were also prominent among in vitro primed naïve T cells. Collectively, these data point to the existence of immunodominant T cell epitopes shared among different Enterobacteriaceae species and targeted by cross‐reactive T cells that are readily found in the pre‐immune repertoire and are clonally expanded in the memory repertoire. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
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41. Prevalence of glaucoma in a low-income population of adults screened during a teleophthalmology campaign in Colombia, South America
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Rueda, Juan Carlos, Sánchez-Uzcátegui, Mary, Paczka, Jose, López-Carreño, Helio, Rueda-Latorre, Daniela, and Paczka-Giorgi, Luz America
- Published
- 2017
- Full Text
- View/download PDF
42. Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23
- Author
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Martínez-Barricarte, Rubén, primary, Markle, Janet G., additional, Ma, Cindy S., additional, Deenick, Elissa K., additional, Ramírez-Alejo, Noé, additional, Mele, Federico, additional, Latorre, Daniela, additional, Mahdaviani, Seyed Alireza, additional, Aytekin, Caner, additional, Mansouri, Davood, additional, Bryant, Vanessa L., additional, Jabot-Hanin, Fabienne, additional, Deswarte, Caroline, additional, Nieto-Patlán, Alejandro, additional, Surace, Laura, additional, Kerner, Gaspard, additional, Itan, Yuval, additional, Jovic, Sandra, additional, Avery, Danielle T., additional, Wong, Natalie, additional, Rao, Geetha, additional, Patin, Etienne, additional, Okada, Satoshi, additional, Bigio, Benedetta, additional, Boisson, Bertrand, additional, Rapaport, Franck, additional, Seeleuthner, Yoann, additional, Schmidt, Monika, additional, Ikinciogullari, Aydan, additional, Dogu, Figen, additional, Tanir, Gonul, additional, Tabarsi, Payam, additional, Bloursaz, Mohammed Reza, additional, Joseph, Julia K., additional, Heer, Avneet, additional, Kong, Xiao-Fei, additional, Migaud, Mélanie, additional, Lazarov, Tomi, additional, Geissmann, Frédéric, additional, Fleckenstein, Bernhard, additional, Arlehamn, Cecilia Lindestam, additional, Sette, Alessandro, additional, Puel, Anne, additional, Emile, Jean-François, additional, van de Vosse, Esther, additional, Quintana-Murci, Lluis, additional, Di Santo, James P., additional, Abel, Laurent, additional, Boisson-Dupuis, Stéphanie, additional, Bustamante, Jacinta, additional, Tangye, Stuart G., additional, Sallusto, Federica, additional, and Casanova, Jean-Laurent, additional
- Published
- 2018
- Full Text
- View/download PDF
43. Immunomodulatory Effects Of Bovine Lactoferrin On Antigen Presenting Cells
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LATORRE, DANIELA, GESSANI, SANDRA, and VALENTI, PIERA
- Subjects
dendritic cells ,monocytes ,Scienze biologiche [Settori Disciplinari MIUR] ,lactoferrin - Published
- 2013
44. Bovine lactoferrin induces CCL1 production in myeloid cells
- Author
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Gessani Sandra, Puddu Patrizia, Valenti Piera, and Latorre Daniela
- Subjects
Chemistry ,Immunology ,Bovine lactoferrin ,Myeloid cells ,Immunology and Allergy ,CCL1 ,Molecular biology - Published
- 2013
- Full Text
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45. Acciónes de grupos sobre el espació de riemann-roch
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Vásquez-Latorre, Daniela, Carocca, Angel, Rojas, Anita M., and Universidad de Chile
- Abstract
Sea G un grupo finito de automorfismos de una curva proyectiva suave X, sobre elcuerpo de los números complejos, y D un divisor no especial de X invariante bajola acción de G. En este trabajo estudiaremos el problema de descomposición de larepresentación natural del grupo G en el espacio de Riemann-Roch L(D), asociadoal divisor D. Presentaremos fórmulas explícitas para la multiplicidad de cada factor irreducible, en términos de la multiplicidad de estos factores en la descomposición de la acción de G, en el espacio dual de las 1-formas diferenciales holomorfas sobre X.Generalizando de esta forma las fórmulas conocidas para la multiplicidad de los factores irreducibles para el caso racional. Doctor en Ciencias Mención Matemáticas TERMINADA PFCHA-Becas 114p. PFCHA-Becas
- Published
- 2013
46. Bovine Lactoferrin-Induced CCL1 Expression Involves Distinct Receptors in Monocyte-Derived Dendritic Cells and Their Monocyte Precursors
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Latorre, Daniela, primary, Pulvirenti, Nadia, additional, Covino, Daniela, additional, Varano, Barbara, additional, Purificato, Cristina, additional, Rainaldi, Gabriella, additional, Gauzzi, Maria, additional, Fantuzzi, Laura, additional, Conti, Lucia, additional, Donninelli, Gloria, additional, Del Cornò, Manuela, additional, Sabbatucci, Michela, additional, Gessani, Sandra, additional, and Puddu, Patrizia, additional
- Published
- 2015
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- View/download PDF
47. ERK phosphorylation and miR-181a expression modulate activation of human memory TH17 cells
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Mele, Federico, primary, Basso, Camilla, additional, Leoni, Cristina, additional, Aschenbrenner, Dominik, additional, Becattini, Simone, additional, Latorre, Daniela, additional, Lanzavecchia, Antonio, additional, Sallusto, Federica, additional, and Monticelli, Silvia, additional
- Published
- 2015
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48. Subnormalidad en productos de grupos
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VASQUEZ LATORRE, DANIELA, CAROCCA BECERRA, ANGEL DENYS, and PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE/FACULTAD DE MATEMATICAS
- Abstract
MAGISTER EN CIENCIAS EXACTAS FONDECYT FONDECYT
- Published
- 2000
49. Bovine Lactoferrin Counteracts Toll-Like Receptor Mediated Activation Signals in Antigen Presenting Cells
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Puddu, Patrizia, primary, Latorre, Daniela, additional, Carollo, Maria, additional, Catizone, Angela, additional, Ricci, Giulia, additional, Valenti, Piera, additional, and Gessani, Sandra, additional
- Published
- 2011
- Full Text
- View/download PDF
50. Reciprocal Interactions between Lactoferrin and Bacterial Endotoxins and Their Role in the Regulation of the Immune Response
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Latorre, Daniela, primary, Puddu, Patrizia, additional, Valenti, Piera, additional, and Gessani, Sandra, additional
- Published
- 2010
- Full Text
- View/download PDF
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