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1. Early seizures and risk of epilepsy and death after intracerebral haemorrhage: The MUCH Italy

Author

Pezzini, Alessandro, primary, Tarantino, Barbara, additional, Zedde, Marialuisa, additional, Marcheselli, Simona, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, DeLodovici, Maria Luisa, additional, Princiotta Cariddi, Lucia, additional, Vidale, Simone, additional, Paciaroni, Maurizio, additional, Azzini, Cristiano, additional, Padroni, Marina, additional, Gamba, Massimo, additional, Magoni, Mauro, additional, Del Sette, Massimo, additional, Tassi, Rossana, additional, De Franco, Ivo Giuseppe, additional, Cavallini, Anna, additional, Calabrò, Rocco Salvatore, additional, Cappellari, Manuel, additional, Giorli, Elisa, additional, Giacalone, Giacomo, additional, Lodigiani, Corrado, additional, Zenorini, Mara, additional, Valletta, Francesco, additional, Cutillo, Gianni, additional, Bonelli, Guido, additional, Abrignani, Giorgia, additional, Castellini, Paola, additional, Genovese, Antonio, additional, Latte, Lilia, additional, Trapasso, Maria Claudia, additional, Ferraro, Chiara, additional, Piancatelli, Francesco, additional, Pascarella, Rosario, additional, Grisendi, Ilaria, additional, Assenza, Federica, additional, Napoli, Manuela, additional, Moratti, Claudio, additional, Acampa, Maurizio, additional, and Grassi, Mario, additional

Published
2024
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2. Statin use and long-term risk of recurrent intracerebral haemorrhage: the MUCH-Italy

Author

Pezzini, Alessandro, Tarantino, Barbara, Zedde, Maria Luisa, Marcheselli, Simona, Silvestrelli, Giorgio, Ciccone, Alfonso, Delodovici, Maria Luisa, Princiotta Cariddi, Lucia, Vidale, Simone, Paciaroni, Maurizio, Azzini, Cristiano, Padroni, Marina, Gamba, Massimo, Magoni, Mauro, Del Sette, Massimo, Tassi, Rossana, de Franco, Ivo Giuseppe, Cavallini, Anna, Calabrò, Rocco Salvatore, Cappellari, Manuel, Giorli, Elisa, Giacalone, Giacomo, Lodigiani, Corrado, Zenorini, Mara, Valletta, Francesco, Pascarella, Rosario, Abrignani, Giorgia, Castellini, Paola, Genovese, Antonio, Latte, Lilia, Trapasso, Maria Claudia, Grisendi, Ilaria, Assenza, Federica, Napoli, Manuela, Moratti, Claudio, Beccattini, Sofia, Acampa, Maurizio, Valzania, Franco, Grassi, Mario, and Gentilini, Davide

Abstract

BackgroundWhether statin use after spontaneous intracerebral haemorrhage (ICH) increases the risk of recurrent ICH is uncertain.MethodsIn the setting of the Multicentric Study on Cerebral Haemorrhage in Italy we followed up a cohort of 30-day ICH survivors, consecutively admitted from January 2002 to July 2014, to assess whether the use of statins after the acute event is associated with recurrent cerebral bleeding.Results1623 patients (mean age, 73.9±10.3 years; males, 55.9%) qualified for the analysis. After a median follow-up of 40.5 months (25th to 75th percentile, 67.7) statin use was not associated with increased risk of recurrent ICH either in the whole study group (adjusted HR, 0.99; 95% CI 0.64 to 1.53) or in the subgroups defined by haematoma location (deep ICH, adjusted HR, 0.74; 95% CI 0.35 to 1.57; lobar ICH, adjusted HR, 1.09; 95% CI 0.62 to 1.90), intensity of statins (low-moderate intensity statins, adjusted HR, 0.93; 95% CI 0.58 to 1.49; high-intensity statins, adjusted HR, 1.48; 95% CI 0.66 to 3.31) and use of statins before the index event (adjusted HR, 0.66; 95% CI 0.38 to 1.17).ConclusionsStatin use appears to be unrelated to the risk of ICH recurrence.

Published
2025
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3. sj-pdf-1-wso-10.1177_1747493020976681 - Supplemental material for Complications of mechanical thrombectomy for acute ischemic stroke: Incidence, risk factors, and clinical relevance in the Italian Registry of Endovascular Treatment in acute stroke

Author

Salsano, Giancarlo, Pracucci, Giovanni, Mavilio, Nicola, Saia, Valentina, Poggio, Monica B Di, Malfatto, Laura, Sallustio, Fabrizio, Wlderk, Andrea, Limbucci, Nicola, Nencini, Patrizia, Vallone, Stefano, Zini, Andrea, Bigliardi, Guido, Velo, Mariano, Francalanza, Isabella, Gennari, Paola, Tassi, Rossana, Bergui, Mauro, Cerrato, Paolo, Carità, Giuseppe, Azzini, Cristiano, Gasparotti, Roberto, Magoni, Mauro, Isceri, Salvatore, Commodaro, Christian, Cordici, Francesco, Menozzi, Roberto, Latte, Lilia, Cosottini, Mirco, Mancuso, Michelangelo, Comai, Alessio, Franchini, Enrica, Alexandre, Andrea, Marca, Giacomo Della, Puglielli, Edoardo, Casalena, Alfonsina, Causin, Francesco, Baracchini, Claudio, Maggio, Luca Di, Naldi, Andrea, Grazioli, Andrea, Forlivesi, Stefano, Chiumarulo, Luigi, Petruzzellis, Marco, Sanfilippo, Giuseppina, Toscano, Gianpaolo, Cavasin, Nicola, Critelli Adriana, Ganimede, Maria Porzia, Prontera, Maria Pia, Giorgianni Andrea, Mauri, Marco, Auteri, William, Petrone, Alfredo, Cirelli, Carlo, Falcou, Anne, Corraine, Simona, Piras, Valeria, Ganci, Giuseppe, Tassinari, Tiziana, Nuzzi, Nunzio Paolo, Corato, Manuel, Sacco, Simona, Squassina, Guido, Invernizzi, Paolo, Gallesio, Ivan, Ferrandi, Delfina, Dui, Giovanni, Deiana, Gianluca, Amistà, Pietro, Russo, Monia, Pintus, Francesco, Baule, Antonio, Craparo, Giuseppe, Mannino, Marina, Castellan, Lucio, Toni, Danilo, and Mangiafico, Salvatore

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-1-wso-10.1177_1747493020976681 for Complications of mechanical thrombectomy for acute ischemic stroke: Incidence, risk factors, and clinical relevance in the Italian Registry of Endovascular Treatment in acute stroke by Giancarlo Salsano, Giovanni Pracucci, Nicola Mavilio, Valentina Saia, Monica B di Poggio, Laura Malfatto, Fabrizio Sallustio, Andrea Wlderk, Nicola Limbucci, Patrizia Nencini, Stefano Vallone, Andrea Zini, Guido Bigliardi, Mariano Velo, Isabella Francalanza, Paola Gennari, Rossana Tassi, Mauro Bergui, Paolo Cerrato, Giuseppe Carità, Cristiano Azzini, Roberto Gasparotti, Mauro Magoni, Salvatore Isceri, Christian Commodaro, Francesco Cordici, Roberto Menozzi, Lilia Latte, Mirco Cosottini, Michelangelo Mancuso, Alessio Comai, Enrica Franchini, Andrea Alexandre, Giacomo Della Marca, Edoardo Puglielli, Alfonsina Casalena, Francesco Causin, Claudio Baracchini, Luca Di Maggio, Andrea Naldi, Andrea Grazioli, Stefano Forlivesi, Luigi Chiumarulo, Marco Petruzzellis, Giuseppina Sanfilippo, Gianpaolo Toscano, Nicola Cavasin, Critelli Adriana, Maria Porzia Ganimede, Maria Pia Prontera, Giorgianni Andrea, Marco Mauri, William Auteri, Alfredo Petrone, Carlo Cirelli, Anne Falcou, Simona Corraine, Valeria Piras, Giuseppe Ganci, Tiziana Tassinari, Nunzio Paolo Nuzzi, Manuel Corato, Simona Sacco, Guido Squassina, Paolo Invernizzi, Ivan Gallesio, Delfina Ferrandi, Giovanni Dui, Gianluca Deiana, Pietro Amistà, Monia Russo, Francesco Pintus, Antonio Baule, Giuseppe Craparo, Marina Mannino, Lucio Castellan, Danilo Toni and Salvatore Mangiafico in International Journal of Stroke

Published
2020
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4. European Multicenter Study of ET-COVID-19

Author

Cagnazzo, Federico, primary, Piotin, Michel, additional, Escalard, Simon, additional, Maier, Benjamin, additional, Ribo, Marc, additional, Requena, Manuel, additional, Pop, Raoul, additional, Hasiu, Anca, additional, Gasparotti, Roberto, additional, Mardighian, Dikran, additional, Piano, Mariangela, additional, Cervo, Amedeo, additional, Eker, Omer Faruk, additional, Durous, Vincent, additional, Sourour, Nader-Antoine, additional, Elhorany, Mahmoud, additional, Zini, Andrea, additional, Simonetti, Luigi, additional, Marcheselli, Simona, additional, Paolo, Nuzzi Nunzio, additional, Houdart, Emmanuel, additional, Guédon, Alexis, additional, Ligot, Noémie, additional, Mine, Benjamin, additional, Consoli, Arturo, additional, Lapergue, Bertrand, additional, Cordona Portela, Pere, additional, Urra, Xabier, additional, Rodriguez, Alejandro, additional, Bolognini, Federico, additional, Lebedinsky, Pablo Ariel, additional, Pasco-Papon, Anne, additional, Godard, Sophie, additional, Marnat, Gaultier, additional, Sibon, Igor, additional, Limbucci, Nicola, additional, Nencini, Patrizia, additional, Nappini, Sergio, additional, Saia, Valentina, additional, Caldiera, Valentina, additional, Romano, Daniele, additional, Frauenfelder, Giulia, additional, Gallesio, Ivan, additional, Gola, Giuliano, additional, Menozzi, Roberto, additional, Genovese, Antonio, additional, Terrana, Alberto, additional, Giorgianni, Andrea, additional, Cappellari, Manuel, additional, Augelli, Raffaele, additional, Invernizzi, Paolo, additional, Pavia, Marco, additional, Lafe, Elvis, additional, Cavallini, Anna, additional, Giossi, Alessia, additional, Besana, Michele, additional, Valvassori, Luca, additional, Macera, Antonio, additional, Castellan, Lucio, additional, Salsano, Giancarlo, additional, Di Caterino, Fortunato, additional, Biondi, Alessandra, additional, Arquizan, Caroline, additional, Lebreuche, Julien, additional, Galvano, Gianluca, additional, Cannella, Alfio, additional, Cosottini, Mirco, additional, Lazzarotti, Guido, additional, Guizzardi, Giuseppe, additional, Stecco, Alessandro, additional, Tassi, Rossana, additional, Bracco, Sandra, additional, Bianchini, Elena, additional, Micieli, Camilla, additional, Pascarella, Rosario, additional, Napoli, Manuela, additional, Causin, Francesco, additional, Desal, Hubert, additional, Cotton, François, additional, Costalat, Vincent, additional, Delvoye, François, additional, Ciccio, Gabriele, additional, Smajda, Stanislas, additional, Redjem, Hocine, additional, Hébert, Solène, additional, Blanc, Raphaël, additional, Mazighi, Mikael, additional, Desilles, Jean-Philippes, additional, Mihoc, Dan, additional, Manisor, Monica, additional, Beaujeux, Rémy, additional, Quenardelle, Véronique, additional, Gheoca, Roxana, additional, Wolff, Valérie, additional, Pero, Guiglielmo, additional, Giuditta, Giussani, additional, Chiara, Ceresa, additional, Riva, Roberto, additional, Cappucci, Matteo, additional, Laubacher, Morgane, additional, Tuttle, Celia, additional, Piergallini, Lorenzo, additional, Turjman, Francis, additional, Clarençon, Frédéric, additional, Shotar, Eimad, additional, Lenck, Stéphanie, additional, Premat, Kevin, additional, Degos, Vincent, additional, Samson, Yves, additional, Rosso, Charlotte, additional, Alamowitch, Sonia, additional, Cirillo, Luigi, additional, Gentile, Mauro, additional, Migliaccio, Ludovica, additional, Isceri, Salvatore, additional, Rossi, Simone, additional, Baldini, Tommaso, additional, Dall’Olio, Massimo, additional, Cellerini, Martino, additional, Saint-Maurice, Jean-Pierre, additional, Civelli, Vittorio, additional, Fantoni, Matteo, additional, Gilles, Naeije, additional, Lise, Jodaïtis, additional, Boris, Lubicz, additional, Elens, Stephanie, additional, Thomas, Bonnet, additional, Adrien, Guenego, additional, Niloufar, Sadeghi, additional, Marc, Van Nuffelen, additional, Maria, Federico Di, additional, Coskun, Oguzhan, additional, Rodesch, Georges, additional, Zimatore, Sergio, additional, Florent, Gariel, additional, Berge, Jérôme, additional, Menegon, Patrice, additional, Barreau, Xavier, additional, Tourdias, Thomas, additional, Olindo, Stéphane, additional, Lucas, Ludovic, additional, Liegey, Jean-Sebastien, additional, Sagnier, Sharmila, additional, Renou, Pauline, additional, Couture, Marie, additional, Debruxelles, Sabrina, additional, Poli, Mathilde, additional, Musacchio, Mariano, additional, Delaitre, Mariette, additional, Padolecchia, Riccardo, additional, Ganci, Giuseppe, additional, Sugo, Annalisa, additional, Stefano, Barbero, additional, Giovanni, Taverna Giacomo, additional, Scoditti, Umberto, additional, Castellini, Paola, additional, Latte, Lilia, additional, Grisendi, Ilaria, additional, Epifani, Enrico, additional, Vizzari, Francesco, additional, Molinaro, Stefano, additional, Nativo, Luca, additional, Vinacci, Gabriele, additional, Bonetti, Bruno, additional, Micheletti, Nicola, additional, Tomelleri, Giampaolo, additional, Zampieri, Piergiuseppe, additional, Plebani, Mauro, additional, Grazioli, Andrea, additional, Ricciardi, Giuseppe Kenneth, additional, Polistena, Alessandra, additional, Alessando, Sgreccia, additional, Sanfilippo, Giuseppina, additional, Persico, Alessandra, additional, Boadu, William, additional, Cuzzoni, Maria Giovanna, additional, Magno, Serena, additional, Toscano, Gianpaolo, additional, Denaro, Maria Federica, additional, Tosi, Piera, additional, Censori, Bruno, additional, Puglisi, Valentina, additional, Vinciguerra, Luisa, additional, De Giuli, Valeria, additional, Mavillo, Nicola, additional, Renieri, Leonardo, additional, Fainardi, Enrico, additional, Vitale, Giovanni, additional, Panagiotis, Primikiris, additional, Charbonnier, Guillaume, additional, Claudio, Moratti, additional, Sallustio, Fabrizio, additional, Wlderk, Andrea, additional, Russo, Riccardo, additional, Bergui, Mauro, additional, Comelli, Chiara, additional, Boghi, Andrea, additional, Moynier, Marinette, additional, Maria Ciceri, Elisa Francesca, additional, Toni, Danilo, additional, Frandon, Julien, additional, Mourand, Isabelle, additional, Gaillard, Nicolas, additional, Mangiafico, Salvatore, additional, Derraz, Imad, additional, Dargazanli, Cyril, additional, Lefevre, Pierre-Henri, additional, Riquelme, Carlos, additional, Gascou, Gregory, additional, and Bonafe, Alain, additional

Published
2021
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5. Complications of mechanical thrombectomy for acute ischemic stroke: Incidence, risk factors, and clinical relevance in the Italian Registry of Endovascular Treatment in acute stroke

Author

Salsano, Giancarlo, primary, Pracucci, Giovanni, additional, Mavilio, Nicola, additional, Saia, Valentina, additional, Bandettini di Poggio, Monica, additional, Malfatto, Laura, additional, Sallustio, Fabrizio, additional, Wlderk, Andrea, additional, Limbucci, Nicola, additional, Nencini, Patrizia, additional, Vallone, Stefano, additional, Zini, Andrea, additional, Bigliardi, Guido, additional, Velo, Mariano, additional, Francalanza, Isabella, additional, Gennari, Paola, additional, Tassi, Rossana, additional, Bergui, Mauro, additional, Cerrato, Paolo, additional, Carità, Giuseppe, additional, Azzini, Cristiano, additional, Gasparotti, Roberto, additional, Magoni, Mauro, additional, Isceri, Salvatore, additional, Commodaro, Christian, additional, Cordici, Francesco, additional, Menozzi, Roberto, additional, Latte, Lilia, additional, Cosottini, Mirco, additional, Mancuso, Michelangelo, additional, Comai, Alessio, additional, Franchini, Enrica, additional, Alexandre, Andrea, additional, Marca, Giacomo Della, additional, Puglielli, Edoardo, additional, Casalena, Alfonsina, additional, Causin, Francesco, additional, Baracchini, Claudio, additional, Di Maggio, Luca, additional, Naldi, Andrea, additional, Grazioli, Andrea, additional, Forlivesi, Stefano, additional, Chiumarulo, Luigi, additional, Petruzzellis, Marco, additional, Sanfilippo, Giuseppina, additional, Toscano, Gianpaolo, additional, Cavasin, Nicola, additional, Adriana, Critelli, additional, Ganimede, Maria Porzia, additional, Prontera, Maria Pia, additional, Andrea, Giorgianni, additional, Mauri, Marco, additional, Auteri, William, additional, Petrone, Alfredo, additional, Cirelli, Carlo, additional, Falcou, Anne, additional, Corraine, Simona, additional, Piras, Valeria, additional, Ganci, Giuseppe, additional, Tassinari, Tiziana, additional, Nuzzi, Nunzio Paolo, additional, Corato, Manuel, additional, Sacco, Simona, additional, Squassina, Guido, additional, Invernizzi, Paolo, additional, Gallesio, Ivan, additional, Ferrandi, Delfina, additional, Dui, Giovanni, additional, Deiana, Gianluca, additional, Amistà, Pietro, additional, Russo, Monia, additional, Pintus, Francesco, additional, Baule, Antonio, additional, Craparo, Giuseppe, additional, Mannino, Marina, additional, Castellan, Lucio, additional, Toni, Danilo, additional, and Mangiafico, Salvatore, additional

Published
2020
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6. IER-SICH Nomogram to Predict Symptomatic Intracerebral Hemorrhage After Thrombectomy for Stroke

Author

Cappellari, Manuel, Mangiafico, Salvatore, Saia, Valentina, Pracucci, Giovanni, Nappini, Sergio, Nencini, Patrizia, Konda, Daniel, Sallustio, Fabrizio, Vallone, Stefano, Zini, Andrea, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Cerrato, Paolo, Pitrone, Antonio, Grillo, Francesco, Saletti, Andrea, De Vito, Alessandro, Gasparotti, Roberto, Magoni, Mauro, Puglielli, Edoardo, Casalena, Alfonsina, Causin, Francesco, Baracchini, Claudio, Castellan, Lucio, Malfatto, Laura, Menozzi, Roberto, Scoditti, Umberto, Comelli, Chiara, Duc, Enrica, Comai, Alessio, Franchini, Enrica, Cosottini, Mirco, Mancuso, Michelangelo, Peschillo, Simone, De Michele, Manuela, Giorgianni, Andrea, Delodovici, Maria Luisa, Lafe, Elvis, Denaro, Maria Federica, Burdi, Nicola, Internò, Saverio, Cavasin, Nicola, Critelli, Adriana, Chiumarulo, Luigi, Petruzzellis, Marco, Doddi, Marco, Carolei, Antonio, Auteri, William, Petrone, Alfredo, Padolecchia, Riccardo, Tassinari, Tiziana, Pavia, Marco, Invernizzi, Paolo, Turcato, Gianni, Forlivesi, Stefano, Ciceri, Elisa Francesca Maria, Bonetti, Bruno, Inzitari, Domenico, Toni, Danilo, Limbucci, Nicola, Consoli, Arturo, Renieri, Leonardo, Fainardi, Enrico, Gandini, Roberto, Pampana, Enrico, Diomedi, Marina, Koch, Giacomo, Verganti, Luca, Sacchetti, Federico, Zelent, Gabriele, Bigliardi, Guido, Picchetto, Livio, Vandelli, Laura, Romano, Daniele Giuseppe, Cioni, Samuele, Gennari, Paola, Cerase, Alfonso, Martini, Giuseppe, Stura, Guido, Daniele, Dino, Naldi, Andrea, Papa, Rosario, Vinci, Sergio Lucio, Bernava, Gianmarco, Velo, Mariano, Caragliano, Antonio, Tessitore, Agostino, Buonomo, Orazio, Musolino, Rossella, La Spina, Paolino, Casella, Carmela, Carolina Fazio, Maria, Cotroneo, Masina, Onofrio, Marcello, Azzini, Cristiano, Casetta, Ilaria, Mardighian, Dikran, Frigerio, Michele, Costa, Angelo, Di Egidio, Vincenzo, Lattanzi, Ruggero, Assetta, Maurizio, Cester, Giacomo, Mavilio, Nicola, Serrati, Carlo, Piazza, Paolo, Epifani, Enrico, Andreone, Andrea, Castellini, Paola, Latte, Lilia, Grisendi, Ilaria, Vaudano, Giacomo, Comelli, Simone, Cavallo, Roberto, Chianale, Gigliola, Simonetti, Luigi, Taglialatela, Francesco, Isceri, Salvatore, Procaccianti, Gaetano, Zaniboni, Anna, Borghi, Annamaria, Bonatti, Giampietro, Ferro, Federica, Bonatti, Matteo, Dall’Ora, Elisa, Currò Dossi, Roberto, Turri, Emanuela, Turri, Mara, Puglioli, Michele, Lazzarotti, Guido, Lauretti, DARIO LUCA, Giannini, Nicola, Maccarone, Miriam, Orlandi, Giovanni, Chiti, Alberto, Guidetti, Giulio, Biraschi, Francesco, Falcou, Anne, Anzini, Alexia, Mancini, Alessandra, Fausti, Silvia, Di Mascio, Maria Teresa, Durastanti, Laura, Sbardella, Emilia, Mellina, Vittorio, Baruzzi, Fabio, Pellegrino, Carlo, Terrana, Alberto, Carimati, Federico, Ruggiero, Maria, Sanna, Antioco, Passarin, Maria Grazia, Colosimo, Cesare, Pedicelli, Alessandro, D’Argento, Francesco, Alexandre, Andrea, Frisullo, Giovanni, Zappoli, Federico, Martignoni, Alessandra, Cavallini, Anna, Persico, Alessandra, Valvassori, Luca, Piano, Mariangela, Agostoni, Elio, Motto, Cristina, Gatti, Antonella, Longoni, Marco, Guccione, Angelo, Tortorella, Rachele, Zampieri, Piergiuseppe, Zimatore, Domenico Sergio, Grazioli, Andrea, Ricciardi, Giuseppe Kenneth, Augelli, Raffaele, Bovi, Paolo, Tomelleri, Giampaolo, Micheletti, Nicola, Semeraro, Vittorio, Lucarelli, Nicola, Ganimede, Maria, Tinelli, Angelica, Pia Prontera, Maria, Pesare, Angela, Cagliari, Enrico, Quatrale, Rocco, Federico, Francesco, Passalacqua, Giovanni, Filauri, Pietro, Orlandi, Berardino, De Santis, Federica, Gabriele, Amleto, Tiseo, Cindy, Armentano, Antonio, Di Benedetto, Olindo, Silvagni, Umberto, Perrotta, Paolo, Crispino, Emanuela, Stancati, Furio, Rizzuto, Stefano, Pugliese, Pierfrancesco, Pisani, Ermanno, Siniscalchi, Antonio, Gaudiano, Carmen, Pirritano, Domenico, Del Giudice, Francesco, Calia, Stefano, Ganci, Giuseppe, Sugo, Annalisa, Scomazzoni, Francesco, Simionato, Franco, Roveri, Luisa, De Nicola, Maurizio, Giannoni, Mirko, Bruni, Stefano, Gambelli, Elena, Provinciali, Leandro, Carriero, Alessandro, Coppo, Lorenzo, Baldan, Julika, Paolo Nuzzi, Nunzio, Marcheselli, Simona, Corato, Manuel, Cotroneo, Enrico, Ricciardi, Fabrizio, Gigli, Renato, Pozzessere, Claudio, Pezzella, Francesca Romana, Corsi, Fabio, Squassina, Guido, Cobelli, Milena, Morassi, Mauro, Magni, Eugenio, Pepe, Fulvio, Bigni, Barbara, Costa, Paolo, Crabbio, Massimo, Griffini, Simona, Palmerini, Francesco, Piras, Maria Paola, Natrella, Massimiliano, Fanelli, Gianluca, Cristoferi, Massimo, Bottacchi, Edo, Corso, Giovanni, Tosi, Piera, Amistà, Pietro, Russo, Monia, Tettoni, Serena, Gallesio, Ivan, Mascolo, Maria Carmela, Meloni, Giovanni Battista, Fabio, Claudio, Maiore, Mario, Pintus, Francesco, Pischedda, Aldo, Manca, Antonio, Mongili, Claudia, Zanda, Bastianina, Sanna, Antonella, Baule, Antonio, Pappalardo, Maria Pia, Craparo, Giuseppe, Gallo, Cristina, Monaco, Serena, Mannino, Marina, Terruso, Valeria, Muto, Mario, Guarnieri, Gianluigi, Andreone, Vincenzo, Dui, Giovanni, Ticca, Anna, Salmaggi, Andrea, Iannucci, Giuseppe, Pinna, Vittore, Di Clemente, Loris, Perini, Francesco, De Boni, Antonella, De Luca, Cristina, De Giorgi, Franco, Corraine, Simona, Enne, Paolo, Ganau, Claudio, and Piras, Valeria

Subjects
Male, medicine.medical_specialty, Fibrinolytic Agents/therapeutic use Humans Male Middle Aged *Nomograms Postoperative Complications/etiology Risk Assessment Risk Factors Stroke/complications/drug therapy/*surgery Thrombectomy/*adverse effects Thrombolytic Therapy/adverse effects, medicine.medical_treatment, contraindications, Risk Assessment, NO, Brain Ischemia, Brain ischemia, Postoperative Complications, Fibrinolytic Agents, Risk Factors, contraindications ◼ logistic models ◼ nomograms ◼ standard of care ◼ thrombectomy, medicine, 80 and over, Humans, Thrombolytic Therapy, Stroke, contraindications, logistic models, nomograms, standard of care, thrombectomy, Aged, Cerebral Hemorrhage, Aged, 80 and over, Advanced and Specialized Nursing, Intracerebral hemorrhage, Receiver operating characteristic, business.industry, Thrombolysis, Nomogram, Middle Aged, medicine.disease, logistic models, nomograms, standard of care, thrombectomy, Female, Thrombectomy, Tissue Plasminogen Activator, Nomograms, Settore MED/26 - NEUROLOGIA, Neurology (clinical), Radiology, Cardiology and Cardiovascular Medicine, business, Fibrinolytic agent, Cohort study
Abstract

Background and Purpose— As a reliable scoring system to detect the risk of symptomatic intracerebral hemorrhage after thrombectomy for ischemic stroke is not yet available, we developed a nomogram for predicting symptomatic intracerebral hemorrhage in patients with large vessel occlusion in the anterior circulation who received bridging of thrombectomy with intravenous thrombolysis (training set), and to validate the model by using a cohort of patients treated with direct thrombectomy (test set). Methods— We conducted a cohort study on prospectively collected data from 3714 patients enrolled in the IER (Italian Registry of Endovascular Stroke Treatment in Acute Stroke). Symptomatic intracerebral hemorrhage was defined as any type of intracerebral hemorrhage with increase of ≥4 National Institutes of Health Stroke Scale score points from baseline ≤24 hours or death. Based on multivariate logistic models, the nomogram was generated. We assessed the discriminative performance by using the area under the receiver operating characteristic curve. Results— National Institutes of Health Stroke Scale score, onset-to-end procedure time, age, unsuccessful recanalization, and Careggi collateral score composed the IER-SICH nomogram. After removing Careggi collateral score from the first model, a second model including Alberta Stroke Program Early CT Score was developed. The area under the receiver operating characteristic curve of the IER-SICH nomogram was 0.778 in the training set (n=492) and 0.709 in the test set (n=399). The area under the receiver operating characteristic curve of the second model was 0.733 in the training set (n=988) and 0.685 in the test set (n=779). Conclusions— The IER-SICH nomogram is the first model developed and validated for predicting symptomatic intracerebral hemorrhage after thrombectomy. It may provide indications on early identification of patients for more or less postprocedural intensive management.

Published
2019

8. Statin use and long-term risk of recurrent intracerebral haemorrhage: the MUCH-Italy.

Author

Pezzini A, Tarantino B, Zedde ML, Marcheselli S, Silvestrelli G, Ciccone A, Delodovici ML, Princiotta Cariddi L, Vidale S, Paciaroni M, Azzini C, Padroni M, Gamba M, Magoni M, Del Sette M, Tassi R, de Franco IG, Cavallini A, Calabrò RS, Cappellari M, Giorli E, Giacalone G, Lodigiani C, Zenorini M, Valletta F, Pascarella R, Abrignani G, Castellini P, Genovese A, Latte L, Trapasso MC, Grisendi I, Assenza F, Napoli M, Moratti C, Beccattini S, Acampa M, Valzania F, Grassi M, and Gentilini D

Subjects
Humans, Male, Female, Aged, Italy epidemiology, Middle Aged, Aged, 80 and over, Risk Factors, Follow-Up Studies, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Hydroxymethylglutaryl-CoA Reductase Inhibitors adverse effects, Cerebral Hemorrhage chemically induced, Recurrence
Abstract

Background: Whether statin use after spontaneous intracerebral haemorrhage (ICH) increases the risk of recurrent ICH is uncertain., Methods: In the setting of the Multicentric Study on Cerebral Haemorrhage in Italy we followed up a cohort of 30-day ICH survivors, consecutively admitted from January 2002 to July 2014, to assess whether the use of statins after the acute event is associated with recurrent cerebral bleeding., Results: 1623 patients (mean age, 73.9±10.3 years; males, 55.9%) qualified for the analysis. After a median follow-up of 40.5 months (25th to 75th percentile, 67.7) statin use was not associated with increased risk of recurrent ICH either in the whole study group (adjusted HR, 0.99; 95% CI 0.64 to 1.53) or in the subgroups defined by haematoma location (deep ICH, adjusted HR, 0.74; 95% CI 0.35 to 1.57; lobar ICH, adjusted HR, 1.09; 95% CI 0.62 to 1.90), intensity of statins (low-moderate intensity statins, adjusted HR, 0.93; 95% CI 0.58 to 1.49; high-intensity statins, adjusted HR, 1.48; 95% CI 0.66 to 3.31) and use of statins before the index event (adjusted HR, 0.66; 95% CI 0.38 to 1.17)., Conclusions: Statin use appears to be unrelated to the risk of ICH recurrence., Competing Interests: Competing interests: AC reports grants from Daiichi-Sankyo; grants from Italfarmaco; and grants from Alexion Pharmaceuticals. MP reports compensation from SANOFI-AVENTIS US LLC for other services; compensation from PFIZER CANADA for other services; compensation from iRhythm Technologies for other services; compensation from Daiichi Sankyo Europe GmbH for other services; and compensation from Bristol-Myers Squibb for other services. The other authors have nothing to disclose., (© Author(s) (or their employer(s)) 2025. No commercial re-use. See rights and permissions. Published by BMJ Group.)

Published
2024
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9. Complications of mechanical thrombectomy for acute ischemic stroke: Incidence, risk factors, and clinical relevance in the Italian Registry of Endovascular Treatment in acute stroke.

Author

Salsano G, Pracucci G, Mavilio N, Saia V, Bandettini di Poggio M, Malfatto L, Sallustio F, Wlderk A, Limbucci N, Nencini P, Vallone S, Zini A, Bigliardi G, Velo M, Francalanza I, Gennari P, Tassi R, Bergui M, Cerrato P, Carità G, Azzini C, Gasparotti R, Magoni M, Isceri S, Commodaro C, Cordici F, Menozzi R, Latte L, Cosottini M, Mancuso M, Comai A, Franchini E, Alexandre A, Marca GD, Puglielli E, Casalena A, Causin F, Baracchini C, Di Maggio L, Naldi A, Grazioli A, Forlivesi S, Chiumarulo L, Petruzzellis M, Sanfilippo G, Toscano G, Cavasin N, Adriana C, Ganimede MP, Prontera MP, Andrea G, Mauri M, Auteri W, Petrone A, Cirelli C, Falcou A, Corraine S, Piras V, Ganci G, Tassinari T, Nuzzi NP, Corato M, Sacco S, Squassina G, Invernizzi P, Gallesio I, Ferrandi D, Dui G, Deiana G, Amistà P, Russo M, Pintus F, Baule A, Craparo G, Mannino M, Castellan L, Toni D, and Mangiafico S

Subjects
Humans, Incidence, Italy epidemiology, Registries, Risk Factors, Treatment Outcome, Brain Ischemia epidemiology, Endovascular Procedures adverse effects, Ischemic Stroke, Stroke epidemiology, Stroke therapy, Thrombectomy adverse effects
Abstract

Background: There are limited data concerning procedure-related complications of endovascular thrombectomy for large vessel occlusion strokes., Aims: We evaluated the cumulative incidence, the clinical relevance in terms of increased disability and mortality, and risk factors for complications., Methods: From January 2011 to December 2017, 4799 patients were enrolled by 36 centers in the Italian Registry of Endovascular Stroke Treatment. Data on demographic and procedural characteristics, complications, and clinical outcome at three months were prospectively collected., Results: The complications cumulative incidence was 201 per 1000 patients undergoing endovascular thrombectomy. Ongoing antiplatelet therapy (p < 0.01; OR 1.82, 95% CI: 1.21-2.73) and large vessel occlusion site (carotid-T, p < 0.03; OR 3.05, 95% CI: 1.13-8.19; M2-segment-MCA, p < 0.01; OR 4.54, 95% CI: 1.66-12.44) were associated with a higher risk of subarachnoid hemorrhage/arterial perforation. Thrombectomy alone (p < 0.01; OR 0.50, 95% CI: 0.31-0.83) and younger age (p < 0.04; OR 0.98, 95% CI: 0.97-0.99) revealed a lower risk of developing dissection. M2-segment-MCA occlusion (p < 0.01; OR 0.35, 95% CI: 0.19-0.64) and hypertension (p < 0.04; OR 0.77, 95% CI: 0.6-0.98) were less related to clot embolization. Higher NIHSS at onset (p < 0.01; OR 1.04, 95% CI: 1.02-1.06), longer groin-to-reperfusion time (p < 0.01; OR 1.05, 95% CI: 1.02-1.07), diabetes (p < 0.01; OR 1.67, 95% CI: 1.25-2.23), and LVO site (carotid-T, p < 0.01; OR 1.96, 95% CI: 1.26-3.05; M2-segment-MCA, p < 0.02; OR 1.62, 95% CI: 1.08-2.42) were associated with a higher risk of developing symptomatic intracerebral hemorrhage compared to no/asymptomatic intracerebral hemorrhage. The subgroup of patients treated with thrombectomy alone presented a lower risk of symptomatic intracerebral hemorrhage (p < 0.01; OR 0.70; 95% CI: 0.55-0.90). Subarachnoid hemorrhage/arterial perforation and symptomatic intracerebral hemorrhage after endovascular thrombectomy worsen both functional independence and mortality at three-month follow-up (p < 0.01). Distal embolization is associated with neurological deterioration (p < 0.01), while arterial dissection did not affect clinical outcome at follow-up., Conclusions: Complications globally considered are not uncommon and may result in poor clinical outcome. Early recognition of risk factors might help to prevent complications and manage them appropriately in order to maximize endovascular thrombectomy benefits.

Published
2021
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