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1. Targeting metastasis-initiating cancer stem cells in gastric cancer with leukaemia inhibitory factor

Author

Seeneevassen, Lornella, Zaafour, Anissa, Sifré, Elodie, Genevois, Coralie, Nguyen, Tra Ly, Pobiedonoscew, Yasmine, Giese, Alban, Guignard, Jérôme, Tiffon, Camille, Rousseau, Benoit, Raymond, Anne-Aurélie, Belleannée, Geneviève, Boeuf, Hélène, Gronnier, Caroline, Martin, Océane C. B., Giraud, Julie, Lehours, Philippe, Dubus, Pierre, and Varon, Christine

Published
2024
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4. Multicenter Retrospective Study of Vascular Infections and Endocarditis Caused by Campylobacter spp., France

Author

Tinevez, Claire, Lehours, Philippe, Ranc, Anne-Gaelle, Belaroussi, Yaniss, Cazanave, Charles, Puges, Mathilde, Velardo, Fanny, Dubois, Damien, Neuwirth, Catherine, Pailhories, Helene, Dorel, Marie, Hery-Arnaud, Genevieve, Join-Lambert, Olivier, Gras, Emmanuelle, Corvec, Stephane, Codde, Cyrielle, Fournier, Damien, Boijout, Hugo, Doat, Violaine, Bouard, Leslie, Lagneaux, Anne-Sophie, Pichon, Maxime, Couzigou, Celia, Letellier, Claire, Lemaignen, Adrien, Bille, Emmanuelle, Berard, Xavier, Caradu, Caroline, Webster, Claire, and Neau, Didier

Subjects
Endocarditis, Bacterial -- Statistics -- Causes of, Campylobacter infections -- Statistics -- Complications and side effects, Blood circulation disorders -- Statistics -- Causes of, Health
Abstract

Campylobacteriosis is the leading cause of food-borne bacterial gastroenteritis. Its incidence in North America, Europe, and Australia is alarming, and data from Africa, Asia, and the Middle East indicate that [...]

Published
2023
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5. CD44v3 is a marker of invasive cancer stem cells driving metastasis in gastric carcinoma

Author

Giraud, Julie, Seeneevassen, Lornella, Rousseau, Benoit, Bouriez, Damien, Sifré, Elodie, Giese, Alban, Nguyen, Tra Ly, Tiffon, Camille, Lippi, Yannick, Azzi-Martin, Lamia, Pannequin, Julie, Ménard, Armelle, Bessède, Emilie, Staedel, Cathy, Mégraud, Francis, Belleannée, Geneviève, Lehours, Philippe, Gronnier, Caroline, Dubus, Pierre, and Varon, Christine

Published
2023
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6. Clinical and Epidemiologic Characteristics and Therapeutic Management of Patients with Vibrio Infections, Bay of Biscay, France, 2001-2019

Author

Hoefler, Florence, Pouget-Abadie, Xavier, Roncato-Saberan, Mariam, Lemarie, Romain, Takoudju, Eve-Marie, Raffi, Francois, Corvec, Stephane, Le Bras, Morgane, Cazanave, Charles, Lehours, Philippe, Guimard, Thomas, and Allix-Beguec, Caroline

Subjects
Bay of Biscay -- Health aspects, Vibrio infections -- Statistics -- Care and treatment -- Diagnosis, Health
Abstract

Some opportunistic pathogens associated with marine environments are already known but until now have caused rare infectious diseases. Among those pathogens are Vibrio spp. other than the well-known V. cholerae [...]

Published
2022
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7. Recurrent Campylobacter jejuni Infections with In Vivo Selection of Resistance to Macrolides and Carbapenems: Molecular Characterization of Resistance Determinants

Author

Alexandra Nunes, Mónica Oleastro, Frederico Alves, Nadia Liassine, David M. Lowe, Lucie Benejat, Astrid Ducounau, Quentin Jehanne, Vítor Borges, João Paulo Gomes, Gauri Godbole, and Lehours Philippe

Subjects
Campylobacter jejuni recurrent infection, immunocompromised patients, macrolide resistance, high-level carbapenem resistance, major porin, Microbiology, QR1-502
Abstract

ABSTRACT We present two independent cases of recurrent multidrug-resistant Campylobacter jejuni infection in immunocompromised hosts and the clinical challenges encountered due to the development of high-level carbapenem resistance. The mechanisms associated with this unusual resistance for Campylobacters were characterized. Initial macrolide and carbapenem-susceptible strains acquired resistance to erythromycin (MIC > 256mg/L), ertapenem (MIC > 32mg/L), and meropenem (MIC > 32mg/L) during treatment. Carbapenem-resistant isolates developed an in-frame insertion resulting in an extra Asp residue in the major outer membrane protein PorA, within the extracellular loop L3 that connects β-strands 5 and 6 and forms a constriction zone involved in Ca2+ binding. The isolates presenting the highest MIC to ertapenem exhibited an extra nonsynonymous mutation (G167A|Gly56Asp) at PorA’s extracellular loop L1. IMPORTANCE Carbapenem susceptibility patterns suggest drug impermeability, related to either insertion and/or single nucleotide polymorphism (SNP) within porA. Similar molecular events occurring in two independent cases support the association of these mechanisms with carbapenem resistance in Campylobacter spp.

Published
2023
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11. Effect of Lactobacillus gasseriBIO6369 and Lacticaseibacillus rhamnosusBIO5326 on Gastric Carcinogenesis Induced by Helicobacter pylori Infection.

Author

Jauvain, Marine, Lepied, Gorann, Bénéjat, Lucie, Roudier, Nathalie, Dussert, Christelle, Lehours, Philippe, Varon, Christine, and Bessède, Emilie

Subjects
HELICOBACTER pylori, LACTIC acid bacteria, HELICOBACTER pylori infections, CANCER stem cells, TIGHT junctions, LACTOBACILLUS rhamnosus
Abstract

Background: Helicobacter pylori infection‐associated gastric adenocarcinoma is influenced by various factors, including the digestive microbiota. Lactic acid bacteria role in digestive carcinogenesis has been discussed, and some Lactobacillaceae family species have been shown to act against H. pylori‐induced inflammation and colonization. However, their effects on H. pylori‐related carcinogenesis have not yet been studied. Lactobacillaceae family effects on the epithelial‐to‐mesenchymal transition (EMT), emergence of cells with cancer stem cell (CSC) properties and the pro‐inflammatory response of gastric epithelial cells to H. pylori infection were investigated. Materials and Methods: A co‐culture model of AGS gastric epithelial cells infected with a carcinogenic strain of H. pylori associated with 18 different probiotic strains candidates were used. Different EMT indicators and CSC properties were studied, including quantification of the mesenchymal phenotype, tumorsphere formation, EMT marker expression, and tight junction evaluation with immunofluorescence microscopy. The effect of the strains on the pro‐inflammatory response to H. pylori was also evaluated by quantifying interleukin‐8 (IL‐8) production using ELISA. Results: Among the strains tested, Lactobacillus gasseri BIO6369 and Lacticaseibacillus rhamnosus BIO5326 induced a 30.6% and 38.4% reduction in the mesenchymal phenotype, respectively, caused a significant decrease in Snail and Zeb1 EMT marker expression and prevented the loss of tight junctions induced by H. pylori infection. A separate co‐culture with a Boyden chamber maintained the effects induced by the two strains. H. pylori‐induced IL‐8 production was also significantly reduced in the presence of L. gasseri BIO6369 and L. rhamnosus BIO5326. Conclusion: Lactobacillus gasseri BIO6369 and L. rhamnosus BIO5326 strains decreased epithelial‐to‐mesenchymal transition and inflammation induced by H. pylori infection, suggesting that these species may have a protective effect against H. pylori‐induced gastric carcinogenesis. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Combined genomic-proteomic approach in the identification of Campylobacter coli amoxicillin-clavulanic acid resistance mechanism in clinical isolates

Author

Deforet, Francis, primary, Jehanne, Quentin, additional, Bénéjat, Lucie, additional, Aptel, Johanna, additional, Prat, Roxane, additional, Desbiolles, Chloé, additional, Ducournau, Astrid, additional, Jauvain, Marine, additional, Bonnet, Richard, additional, Vandenesch, François, additional, Lemoine, Jérôme, additional, and Lehours, Philippe, additional

Published
2023
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15. Erratum for Nunes et al., “Recurrent Campylobacter jejuni Infections with In Vivo Selection of Resistance to Macrolides and Carbapenems: Molecular Characterization of Resistance Determinants”

Author

Nunes, Alexandra, primary, Oleastro, Mónica, additional, Alves, Frederico, additional, Liassine, Nadia, additional, Lowe, David M., additional, Benejat, Lucie, additional, Ducounau, Astrid, additional, Jehanne, Quentin, additional, Borges, Vítor, additional, Gomes, João Paulo, additional, Godbole, Gauri, additional, and Lehours, Philippe, additional

Published
2023
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18. Recurrent Cellulitis Revealing Helicobacter cinaedi in Patient on Ibrutinib Therapy, France

Author

Roupie, Anne-Laure, Lafont, Emmanuel, Fraitag, Sylvie, Ferroni, Agnes, Lecuyer, Herve, Boccara, Olivia, Bessede, Emilie, Lehours, Philippe, Lefrere, Francois, and Lortholary, Olivier

Subjects
Helicobacter infections -- Case studies -- Complications and side effects, Diseases -- Relapse, Cellulitis -- Case studies -- Causes of, Health
Abstract

A 61-year-old man who had been treated for 4 years with the Bruton's tyrosine-kinase (BTK) inhibitor ibrutinib as a first-line therapy for chronic lymphocytic leukemia (CLL) sought treatment for a [...]

Published
2023
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20. Campylobacter fetus foodborne illness outbreak in the elderly

Author

Grouteau, Gaspard, primary, Mignonat, Cédric, additional, Marchou, Bruno, additional, Martin-Blondel, Guillaume, additional, Glass, Olivier, additional, Roubaud-Baudron, Claire, additional, Lansalot-Matras, Pauline, additional, Alik, Simon, additional, Balardy, Laurent, additional, De Nadaï, Thomas, additional, Bénéjat, Lucie, additional, Jehanne, Quentin, additional, Le Coustumier, Alain, additional, and Lehours, Philippe, additional

Published
2023
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22. Incidence of paediatric pneumococcal meningitis and emergence of new serotypes: a time-series analysis of a 16-year French national survey

Author

Adam, Marie Noelle, Agha-Mir, Ilhem, Akitani, Sylvia, Amara, Marlène, Arlet, Guillaume, Asensio, Valérie, Autret, Fanny, Baleine, Julien, Barnaud, Guilaine, Barrans, Alain, Barsotti, Katia, Basmaci, Romain, Bednarek, Nathalie, Belgaid, Abdelmalek, Benoist, Grégoire, Bertrou, Anne, Biessy, Hélène, Biran, Valérie, Blanc, Véronique, Blondel, Elodie, Bolot, Pascal, Bosi, Claude, Boyer, Sophie, Brouard, Jacques, Cartier-Riviere, Bernadette, Cascarigny, Françoise, Cattoen, Christian, Chace, Anne, Chalumeau, Martin, Chamouilli, Jean Marc, Chaplain, Chantal, Charachon, Sylvie, Charbonneau, Anne, Cheron, Mireille, Chevallier, Bertrand, Chomienne, Francis, Courouble, Gery, Danekova, Nevena, Dao-Dubremetz, Anne, Daoud, Patrick, Dauger, Stéphane, De Champs, Christophe, De Luca, Danièle, De Briel, André, Decobert, Marion, Desbois, Delphine, Despert, Véronique, Dessein, Rodrigue, Dessioux, Emmanuelle, Dieckmann, Katherine, Dommergues, Marie Aliette, Dorangeon, Elodie, Doucet-Populaire, Florence, Dubos, François, Dubourg, Grégory, Dufour, Marie Josée, Duval, Véronique, Eitenschenck, Laurence, Epaud, Ralph, Evreux, Françoise, Eyer, Didier, Eyssette-Gayraud, Stéphanie, Fabbro, Chrystèle, Faye, Albert, Ferroni, Agnes, Fos, Marie Pierre, Gallet, Serge, Garandeau, Caroline, Garrec, Hélène, Gaschignard, Jean, Gaudelus, Joel, Geniez, Laurent, Girard, Florent, Glastre, Catherine, Glatz, Isabelle, Goudeau, Alain, Gougeon Jollivet, Anne, Goumy, Pierre, Gouraud, François, Goux, Alain, Grando, Anna, Grimprel, Emmanuel, Guilluy, Olivier, Guyon, Gael, Guyot, Caroline, Haas, Hervé, Haegy-Doehring, Isabelle, Halna, Muriel, Hamdad, Farida, Haouisee, Severine, Herve, Christian, Heyman Guenais, Rachel, Hochart, Anne Cécile, Honore Bouakline, Stéphanie, Hubert, Nathalie, Jan, Didier, Javouhey, Etienne, Jeannot, Emmanuel, Jehan, Josette, Juvin, Marie Emmanuelle, Kalach, Nicolas, Khalfi, Ali, Labrune, Philippe, Lafendi, Leila, Lahrach, Hakim, Laisney, Norbert, Landragin, Danielle, Lapeyre, Fabrice, Laugel, Vincent, Launay, Elise, Lavigne, Jean Philippe, Le Bideau, Marc, Ledru, Sylvie, Lehours, Philippe, Lejri, Nejib, Lemenand, Olivier, Lorrot, Mathie, Lureau, Pierre, M'Bamba, Célestin, Macchi, Valérie, Madhi, Fouad, Marcou, Valérie, Marin, Mariane, Martha, Sandrine Anne, Martinot, Alain, Mezgueldi, Ellia, Micaelo, Maité, Milcent, Karen, Minette Brunel, Delphine, Moissenet, Didier, Moquet, Olivier, Morisot, Cyril, Moulene, Eric, Nicola, Nawal, Oulepsir, Abdelaziz, Pantalone, Leatitia, Patoz, Pierre, Pellegrino, Beatrice, Penel-Capelle, Delphine, Pierre, Marie Hélène, Pinquier, Didier, Pitsch, Aurélia, Plassart, Claire, Porcheret, Huong, Prere, Marie Françoise, Raymond, Josette, Rey, Agnes, Richardin, Florence, Roussellier, Patricia, Roux, Anne Laure, Roybet, Danielle, Sadik, Ahmed, Sarlangue, Jean, Saumureau, Simone, Savoy, Isabelle, Schneider, Jean Marc, Sebag, Olivier, Sivadon-Tardy, Valérie, Soustelle, Nicolas, Texier, Anthony, Thouvenin, Maxime, Toubiana, Julie, Tronc, Fréderic, Twizeyimana, Eterne, Vachee, Anne, Vernet-Garnier, Véronqiue, Vervel, Christine, Violette, Jérémie, Wallet, Fréderic, Warin, Laure, Yangui, Mohamed Amine, Ythier, Hubert, Zimmermann, Brigitte, Ouldali, Naim, Levy, Corinne, Varon, Emmanuelle, Bonacorsi, Stéphane, Béchet, Stéphane, Cohen, Robert, and Angoulvant, François

Published
2018
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25. APRIL-producing eosinophils are involved in gastric MALT lymphomagenesis induced by Helicobacter sp infection

Author

Blosse, Alice, Peru, Sara, Levy, Michael, Marteyn, Benoit, Floch, Pauline, Sifré, Elodie, Giese, Alban, Prochazkova-Carlotti, Martine, Azzi Martin, Lamia, Dubus, Pierre, Mégraud, Francis, Ruskone Fournestraux, Agnès, Fabiani, Bettina, Copie Bergman, Christiane, Robe, Cyrielle, Hahne, Michael, Huard, Bertrand, and Lehours, Philippe

Published
2020
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27. Dynamics of the digestive acquisition of bacterial carriage and integron presence by French preterm newborns according to maternal colonization: The DAIR3N multicentric study

Author

Patry, Alice, primary, Bothorel, Philippe, additional, Labrunie, Anaïs, additional, Renesme, Laurent, additional, Lehours, Philippe, additional, Benard, Melinda, additional, Dubois, Damien, additional, Ponthier, Laure, additional, Meyer, Sylvain, additional, Norbert, Karine, additional, Villeneuve, Laurent, additional, Jouvencel, Philippe, additional, Leysenne, David, additional, Chainier, Delphine, additional, Luce, Sandrine, additional, Grélaud, Carole, additional, Ploy, Marie-Cecile, additional, Bedu, Antoine, additional, and Garnier, Fabien, additional

Published
2023
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31. CD44v3 is a marker of invasive cancer stem cells driving metastasis in gastric carcinoma

Author

Giraud, Julie, primary, Seeneevassen, Lornella, additional, Rousseau, Benoit, additional, Bouriez, Damien, additional, Sifré, Elodie, additional, Giese, Alban, additional, Nguyen, Tra Ly, additional, Tiffon, Camille, additional, Lippi, Yannick, additional, Azzi-Martin, Lamia, additional, Pannequin, Julie, additional, Ménard, Armelle, additional, Bessède, Emilie, additional, Staedel, Cathy, additional, Mégraud, Francis, additional, Belleannée, Geneviève, additional, Lehours, Philippe, additional, Gronnier, Caroline, additional, Dubus, Pierre, additional, and Varon, Christine, additional

Published
2022
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32. Genomic Diversity of Campylobacter lari Group Isolates from Europe and Australia in a One Health Context

Author

Gourmelon, Michele, primary, Boukerb, Amine M., additional, Nabi, Nesrine, additional, Banerji, Sangeeta, additional, Joensen, Katrine G., additional, Serghine, Joelle, additional, Cormier, Alexandre, additional, Megraud, Francis, additional, Lehours, Philippe, additional, Alter, Thomas, additional, Ingle, Danielle J., additional, Kirk, Martyn D., additional, and Nielsen, Eva M., additional

Published
2022
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35. Nrf2 Downregulation Contributes to Epithelial-to-Mesenchymal Transition in Helicobacter pylori-Infected Cells

Author

Bacon, Sarah, primary, Seeneevassen, Lornella, additional, Fratacci, Alison, additional, Rose, Faustine, additional, Tiffon, Camille, additional, Sifré, Elodie, additional, Haykal, Maria M., additional, Moubarak, Maya M., additional, Ducournau, Astrid, additional, Bruhl, Lucie, additional, Claverol, Stéphane, additional, Tokarski, Caroline, additional, Gouloumi, Alina-Roxani, additional, Pateras, Ioannis S., additional, Daubon, Thomas, additional, Lehours, Philippe, additional, Varon, Christine, additional, and Martin, Océane C. B., additional

Published
2022
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40. List of Contributors

Author

Abrahamian, Fredrick M., primary, Aldape, Michael J., additional, Aldasoro, Edelweiss, additional, Allen, Upton D., additional, Al-Sum, Hythem, additional, Anadkat, Milan J., additional, Anders, Katherine, additional, Angelakis, Emmanouil, additional, Angus, Brian John, additional, Antoniadou, Anastasia, additional, Arena, Fabio, additional, Arends, Joop E., additional, Arribas, Jose R., additional, Artenstein, Andrew W., additional, Atherton, John C., additional, Aucott, John N., additional, Aw, Tar-Ching, additional, Babcock, Hilary M., additional, Bailey, Robin, additional, Bailey, Thomas C., additional, Banks, Adam Z., additional, Barillo, David J., additional, Barrette, Ernie-Paul, additional, Bauer, Martijn P., additional, Bayston, Roger, additional, Beard, C. Ben, additional, Beardsley, Justin, additional, Beeching, Nick J., additional, Bégué, Rodolfo E., additional, Beldi, Guido, additional, Benson, Constance A., additional, Berbari, Elie F., additional, Berenger, Jean-Michel, additional, Berger, Christoph, additional, Bernardino, Jose I., additional, Bille, Jacques, additional, Billioux, Alexander C., additional, Bitnun, Ari, additional, Blair, Iain, additional, Blanche, Stéphane, additional, Bleck, Thomas P., additional, Bleeker-Rovers, Chantal P., additional, Bleijenberg, Gijs, additional, Bloch, Karen C., additional, Blum, Johannes, additional, Blumberg, Emily A., additional, Bonomo, Robert A., additional, Bonten, Marc J.M., additional, Bourayou, Rafik, additional, Bouza, Emilio, additional, Brandt, K. Ashley, additional, Bretelle, Florence, additional, Brisse, Sylvain, additional, Britton, Warwick J., additional, Brook, Itzhak, additional, Brouwer, Matthijs C., additional, Browne, Sarah K., additional, Bryant, Amy E., additional, Bühler, Silja, additional, Bulger, Eileen M., additional, Buller, R. Mark L., additional, Burke, Leah A., additional, Burri, Christian, additional, Butler, Marcus W., additional, Calandra, Thierry, additional, Calfee, David P., additional, Calvo-Cano, Antonia, additional, Cameron, D. William, additional, Carcillo, Joseph A., additional, Carson, Gail, additional, Chambers, Stephen T., additional, Charrel, Remi N., additional, Nguyen, Vinh Chau Van, additional, Chevaliez, Stéphane, additional, Chiller, Tom M., additional, Christaki, Eirini, additional, Chung, Kevin K., additional, Clifford, David B., additional, Clumeck, Nathan, additional, Cohen, Jonathan, additional, Collinge, John, additional, Conlon, Christopher P., additional, Conrad, Curdin, additional, Cooke, Fiona J., additional, Cope, Jennifer Rittenhouse, additional, Corey, G. Ralph, additional, Cross, John H., additional, Cunha, Burke A., additional, Cunha, Cheston B., additional, D'Journo, Benoit, additional, Daikos, George L., additional, Daniels, Johannes M.A., additional, Davidson, Robert N., additional, Day, Nicholas P.J., additional, De Cock, Kevin M., additional, de Silva, Thushan I., additional, de Vries, Henry J.C., additional, de Wit, Stéphane, additional, Delaloye, Julie, additional, Denning, David W., additional, Dennis, David T., additional, Dhanireddy, Shireesha, additional, Dielubanza, Elodi J., additional, Diemert, David J., additional, Doganay, Mehmet, additional, Doherty, Tom, additional, Dolecek, Christiane, additional, Dondorp, Arjen M., additional, Douglas, Abby, additional, Drancourt, Michel, additional, Dubourg, Grégory, additional, Dudley, Michael N., additional, Durand, Guillaume, additional, Eckhardt, Benjamin J., additional, Efstratiou, Androulla, additional, Ekkelenkamp, Miquel B., additional, Eranki, Ambika, additional, Erdem, Hakan, additional, Escota, Gerome V., additional, Evans, Heather L., additional, Eziefula, Alice Chijioke, additional, Fenollar, Florence, additional, Fenwick, Alan, additional, Fierer, Joshua, additional, Finch, Roger G., additional, Fleckenstein, James M., additional, Forstner, Christina, additional, Foschi, Federico, additional, Fournier, Pierre-Edouard, additional, French, Martyn A., additional, Gage, Kenneth L., additional, Garcia, Lynne S., additional, Gascon, Joaquim, additional, Gastañaduy, Arturo S., additional, Gautret, Philippe, additional, Geisler, William M., additional, Ghanem, Khalil G., additional, Giani, Tommaso, additional, Giannella, Maddalena, additional, Gilliam, Bruce L., additional, Gilliet, Michel, additional, Glaser, Carol A., additional, Glupczynski, Youri, additional, Gnann, John W., additional, Goldstein, Ellie J.C., additional, Gottstein, Bruno, additional, Gouriet, Frederique, additional, Gravitt, Patti E., additional, Green, Michael D., additional, Green, Stephen T., additional, Groll, Andreas H., additional, Gulick, Roy M., additional, Gupta, Arjun, additional, Habib, Gilbert, additional, Harbarth, Stephan, additional, Harris, Marianne, additional, Hayden, Frederick G., additional, Hetem, David J., additional, Hill, Philip C., additional, Hirschel, Bernard, additional, Hodowanec, Aimee C., additional, Hoffart, Louis, additional, Hoffmann, Christian, additional, Holland, Steven M., additional, Horby, Peter W., additional, Horne, David J., additional, Hraiech, Sami, additional, Hull, Mark W., additional, Huttner, Angela, additional, Ingram, Richard J.M., additional, Islam, Jasmin, additional, Ison, Michael G., additional, James, Scott H., additional, Jenkins, Claire, additional, Jenkins, Stephen G., additional, Jensen, Jørgen Skov, additional, Johnston, Christine, additional, Jones, Theodore B., additional, Jordan, Stephen J., additional, Julian, Kathleen G., additional, Kato, Yasuyuki, additional, Kauffman, Carol A., additional, Kaye, Keith S., additional, Keane, Michael P., additional, Keeney, James, additional, Kelly, Paul, additional, Kent, Stephen J., additional, Kern, Winfried V., additional, Keynan, Yoav, additional, Kim, Andrea A., additional, Koné-Paut, Isabelle, additional, Kosmidis, Chris, additional, Kroes, Aloys C.M., additional, Kroon, Frank P., additional, Ksiazek, Thomas G., additional, Kuhlmann, F. Matthew, additional, Kuijper, Ed J., additional, Kwon, Jennie H., additional, Kyei, George B., additional, Lacombe, Karine, additional, Lagacé-Wiens, Philippe, additional, Lagier, Jean-Christophe, additional, Lamagni, Theresa, additional, Landraud, Luce, additional, Lanternier, Fanny, additional, LaPlante, Kerry L., additional, Lawn, Stephen D., additional, Lawrence, Steven J., additional, Leblebicioglu, Hakan, additional, Lee, Nelson, additional, Leggett, James E., additional, Lehours, Philippe, additional, Levy, Pierre-Yves, additional, Leyh, Rainer G., additional, Lillis, Rebecca A., additional, Limmathurotsakul, Direk, additional, Lin, Jennifer, additional, Lindquist, H.D. Alan, additional, Lipsky, Benjamin A., additional, Liscynesky, Christina, additional, Looney, David, additional, Lortholary, Olivier, additional, Lowy, Franklin D., additional, Luft, Benjamin J., additional, Mackowiak, Philip A., additional, MacPherson, Paul A., additional, Maghraoui-Slim, Valérie, additional, Mallon, Patrick W., additional, Mangino, Julie E., additional, Manuel, Oriol, additional, Marchetti, Oscar, additional, Marks, Kristen M., additional, Marr, Kieren A., additional, Marrazzo, Jeanne, additional, Marschall, Jonas, additional, Martin, David H., additional, Matonti, Frédéric, additional, Matulewicz, Richard S., additional, Mayer, Kenneth H., additional, McCulloh, Russell J., additional, McGready, Rose, additional, Mdodo, Rennatus, additional, Mead, Simon, additional, Mégraud, Francis, additional, Meintjes, Graeme, additional, Metcalf, Sarah C., additional, Michaels, Marian G., additional, Migliori, Giovanni Battista, additional, Miles, Michael A., additional, Miller, Alastair, additional, Mimiaga, Matthew J., additional, Mingeot-Leclercq, Marie-Paule, additional, Misch, Elizabeth Ann, additional, Mitreva, Makedonka, additional, Montaner, Julio S.G., additional, Moore, Caroline B., additional, Muñoz, Patricia, additional, Muñoz, Jose, additional, Murray, Clinton K., additional, Musso, Didier, additional, Mutengo, Mable, additional, Mutizwa, Misha M., additional, Naber, Kurt G., additional, Natarajan, Pavithra, additional, Neme, Santiago, additional, Newton, Paul N., additional, Nichols, Ronald A., additional, Nicolle, Lindsay E., additional, Nosten, François, additional, Notarangelo, Luigi D., additional, Nutman, Thomas B., additional, Nyirjesy, Paul, additional, O'Connell, P. Ronan, additional, Opal, Steven M., additional, Ormerod, L. Peter, additional, Osmon, Douglas R., additional, Pankert, Marie Boulze, additional, Pantaleo, Giuseppe, additional, Papazian, Laurent, additional, Parente, Diane M., additional, Parola, Philippe, additional, Parsaei, Shadi, additional, Pascual, Manuel A., additional, Patel, Rupa, additional, Patrozou, Eleni, additional, Pawlotsky, Jean-Michel, additional, Peacock, Sharon J., additional, Pechère, Jean-Claude, additional, Pelegrin, Ivan, additional, Peters, Barry S., additional, Peters, Edgar J.G., additional, Petersen, Jeannine M., additional, Petersen, Lyle R., additional, Petraitis, Vidmantas, additional, Pham, Luu-Ly, additional, Picado, Albert, additional, Pilatz, Adrian, additional, Pilmis, Benoit, additional, Pinazo, María-Jesús, additional, Pletz, Mathias W., additional, Pogue, Jason M., additional, Polgreen, Evelyn L., additional, Polgreen, Philip M., additional, Posfay-Barbe, Klara M., additional, Powderly, William G., additional, Presti, Rachel, additional, Prod'hom, Guy, additional, Puolakkainen, Mirja, additional, Quinn, Thomas C., additional, Raoult, Didier, additional, Razonable, Raymund R., additional, Read, Robert C., additional, Redfield, Robert R., additional, Rentenaar, Rob J., additional, Reynolds, Steven J., additional, Ribi, Camillo, additional, Richardson, Malcolm D., additional, Ritter, Michele L., additional, Roch, Antoine, additional, Rockstroh, Jürgen Kurt, additional, Rojek, Amanda, additional, Romero, José R., additional, Rooijakkers, Suzan H.M., additional, Rosenbluth, Daniel, additional, Rosenzweig, Sergio D., additional, Rossolini, Gian Maria, additional, Rubinstein, Ethan, additional, Ryan, Greg, additional, Safren, Steven A., additional, Sahasrabuddhe, Vikrant V., additional, Saikku, Pekka A.I., additional, Sajadi, Mohammad M., additional, Salvaggio, Michelle R., additional, Santos, Carlos A.Q., additional, Satlin, Michael J., additional, Schaeffer, Anthony J., additional, Schimmer, Christoph, additional, Schooley, Robert T., additional, Schumacher, Richard F., additional, Sha, Beverly E., additional, Shapiro, Daniel S., additional, Sheehan, Gerard, additional, Shlaes, David M., additional, Shoham, Shmuel, additional, Simmons, Cameron P., additional, Simon, Dennis W., additional, Simon, Matthew S., additional, Simonsen, Kari A., additional, Slack, Mary P.E., additional, Smith, Tyrel T., additional, Sobel, Jack D., additional, Souli, Maria, additional, Sridhar, Shruti, additional, Steckelberg, James M., additional, Stevens, Dennis L., additional, Strah, Heather, additional, Sturm, A. Willem, additional, Sungkanuparph, Somnuek, additional, Tabrizi, Sarah J., additional, Tacconelli, Evelina, additional, Tan, Chen Sabrina, additional, Taplitz, Randy A., additional, Thomas, Guillemette, additional, Thomas, Lora D., additional, Thuny, Franck, additional, Thwaites, Guy, additional, Tissot, Frederic, additional, Tønjum, Tone, additional, Torriani, Francesca J., additional, Toso, Christian, additional, Tulkens, Paul M., additional, Tunkel, Allan R., additional, Turner, Claire E., additional, Ustianowski, Andrew P., additional, van Bambeke, Françoise, additional, van Crevel, Reinout, additional, van de Beek, Diederik, additional, van Delden, Christian, additional, van der Eerden, Menno M., additional, van der Meer, Jos W.M., additional, van der Poll, Tom, additional, van Ingen, Jakko, additional, van Putten, Jos, additional, Vaudaux, Bernard P., additional, Vermund, Sten H., additional, Viscidi, Raphael P., additional, Visvanathan, Kumar, additional, Visvesvara, Govinda S., additional, von Seidlein, Lorenz, additional, Wagenlehner, Florian M.E., additional, Wald, Anna, additional, Walsh, Thomas J., additional, Warhurst, David C., additional, Warnock, David W., additional, Warrell, David A., additional, Warrell, Mary J., additional, Warris, Adilia, additional, Watkins, Richard R., additional, Weatherall, David J., additional, Weber, Rainer, additional, Weidner, Wolfgang, additional, White, Jonathan R., additional, White, Peter J., additional, Whitehorn, James, additional, Whitley, Richard J., additional, Whitty, Christopher J.M., additional, Wiersinga, Willem Joost, additional, Wilcox, Mark H., additional, Williams, Thomas N., additional, Wilson, Cara C., additional, Wilson, Mary Elizabeth, additional, Wisplinghoff, Hilmar, additional, Wood, Robin, additional, Wunderink, Richard G., additional, Wyles, David, additional, Yang, Zhi-Tao, additional, Yoder, Jonathan S., additional, Zaidi, Najam A., additional, Zimmer, Andrea J., additional, Zuckerman, Jane N., additional, and Zumla, Alimuddin, additional

Published
2017
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43. Genome-wide identification of host-segregating SNPs for source attribution of clinical Campylobacter coli isolates

Author

Lehours, Philippe, Jehanne, Quentin, Pascoe, Ben, Benejat, Lucie, Ducournau, Astrid, Mourkas, Evangelos, Mégraud, Francis, Bessède, Emilie, Sheppard, Samuel, Centre National de Référence des Campylobacters et des Hélicobacters [Bordeaux] (CNRCH), Physiopathologie du cancer du foie, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Biology and Biochemistry [Bath, Royaume-Uni], Milner Centre for Evolution [Bath, Royaume-Uni], University of Bath [Bath]-University of Bath [Bath], Biochemistry and Molecular Biology Unit, Department of Basic Sciences, School of Medicine, University of Kinshasa (UNIKIN), LEHOURS, PHILIPPE, and University of Bath [Bath]

Subjects
[SDV] Life Sciences [q-bio], [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, [SDV]Life Sciences [q-bio], [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology
Abstract

International audience; Campylobacter is among the most common causes of gastroenteritis worldwide. Campylobacter jejuni and Campylobacter coli are the most common species causing human-disease. DNA-sequence-based methods for strain characterization have focussed largely on C. jejuni, responsible for 80-90% of infections, meaning that C. coli epidemiology has lagged behind. Here we have analyzed the genome of 450 C. coli isolates to determine genetic markers that can discriminate isolates sampled from 3 major reservoir hosts (chickens, cattle and pigs). These markers were then applied to identify the source of infection of 147 C. coli from French clinical cases. Using STRUCTURE software, 259 potential host-segregating markers were revealed by probabilistic characterization of SNP frequency variation in strain collections from three different hosts. These SNPs were found in 41 genes or intergenic regions, mostly coding for proteins involved in motility and membrane functions. Source attribution of clinical isolates based on the differential presence of these markers confirmed chicken as the most common source of C. coli infection in France.IMPORTANCE Genome-wide and source attribution studies based on Campylobacter species have shown their importance for the understanding of foodborne infections. Although the use of MLST based on 7 genes from C. jejuni is a powerful method to structure populations, when applied to C. coli results have not clearly demonstrated their robustness. Therefore, we aim here to provide more accurate data based on the identification of single-nucleotide polymorphisms. Results from this study reveal an important number of host-segregating SNPs, found in proteins implied in motility, membrane functions or DNA repair systems. These findings offer new interesting opportunities for further study on C. coli adaptation to its environment. Additionally, the results demonstrate that poultry is potentially the main reservoir of C. coli in France.

Published
2020

46. Evolution of Bordetella pertussis over a 23-year period in France, 1996 to 2018

Author

Bouchez, Valérie, Guillot, Sophie, Landier, Annie, Armatys, Nathalie, Matczak, Soraya, Toubiana, Julie, Brisse, Sylvain, Brieu, Nathalie, Hamdad, Farida, Kempf, Marie, Pailhoriès, Hélène, Jensen, Cécile, Lehours, Philippe, Guiraud, Jennifer, Le Bars, Hervé, Isnard, Christophe, Wilhelm, Nathalie, Le Coustumier, Alain, Delmas, Julien, De Briel, Dominique, Souply, Laurent, Aberrane, Saïd, Coudé, Marie, Garnier, Fabien, Descours, Ghislaine, Jean-Pierre, Hélène, Alauzet, Corentine, Gibaud, Sophie-Anne, Bonacorsi, Stéphane, Brasme, Lucien, Lemée, Ludovic, Koebel, Christelle, Lanotte, Philippe, Bland, Stéphane, Petitprez, Hélène, Raffenot, Didier, Levast, Marion, Doucet-Populaire, Florence, Bourgeois-Nicolaos, Nadège, Burucoa, Christophe, Grattard, Florence, Marque-Juillet, Stéphanie, Biodiversité et Epidémiologie des Bactéries pathogènes - Biodiversity and Epidemiology of Bacterial Pathogens, Institut Pasteur [Paris], Centre national de Référence de la Coqueluche et autres Bordetelloses - National Reference Center for Whooping Cough and other Bordetella infections (CNR), Collège doctoral [Sorbonne universités], Sorbonne Université (SU), Département de Pédiatrie et maladies infectieuses [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Paris (UP), This work was performed with the financial support of the Institut Pasteur and of Santé Publique France., French pertussis microbiology study group: Nathalie Brieu, Farida Hamdad, Marie Kempf, Hélène Pailhoriès, Cécile Jensen, Philippe Lehours, Jennifer Guiraud, Hervé Le Bars, Christophe Isnard, Nathalie Wilhelm, Alain Le Coustumier, Julien Delmas, Dominique De Briel, Laurent Souply, Saïd Aberrane, Marie Coudé, Fabien Garnier, Ghislaine Descours, Hélène Jean-Pierre, Corentine Alauzet, Sophie-Anne Gibaud, Stéphane Bonacorsi, Lucien Brasme, Ludovic Lemée, Christelle Koebel, Philippe Lanotte, Stéphane Bland, Hélène Petitprez, Didier Raffenot, Marion Levast, Florence Doucet-Populaire, Nadège Bourgeois-Nicolaos, Christophe Burucoa, Florence Grattard, Stéphanie Marque-Juillet, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Collège Doctoral, Université Paris Cité (UPCité), and Institut Pasteur [Paris]-Institut Pasteur [Paris]

Subjects
Serotype, Bordetella pertussis, population evolution, Whooping Cough, Epidemiology, [SDV]Life Sciences [q-bio], Fimbria, MESH: Pertussis Toxin, MESH: Virulence Factors, Bordetella, Pertussis toxin, Microbiology, pertactin, MESH: Bordetella pertussis, 03 medical and health sciences, 0302 clinical medicine, Antigen, Virology, MESH: Child, medicine, Humans, Virulence Factors, Bordetella, 030212 general & internal medicine, Child, Whooping cough, 030304 developmental biology, Pertussis Vaccine, vaccine antigen deficiency, 0303 health sciences, Surveillance, MESH: Humans, biology, MESH: Bacterial Outer Membrane Proteins, Public Health, Environmental and Occupational Health, MESH: Whooping Cough, biology.organism_classification, medicine.disease, fimbriae serotype, 3. Good health, respiratory tract diseases, Vaccination, MESH: France, Pertussis Toxin, MESH: Pertussis Vaccine, France, Pertactin, Bacterial Outer Membrane Proteins
Abstract

Background Bordetella pertussis is the main agent of whooping cough. Vaccination with acellular pertussis vaccines has been largely implemented in high-income countries. These vaccines contain 1 to 5 antigens: pertussis toxin (PT), filamentous haemagglutinin (FHA), pertactin (PRN) and/or fimbrial proteins (FIM2 and FIM3). Monitoring the emergence of B. pertussis isolates that might partially escape vaccine-induced immunity is an essential component of public health strategies to control whooping cough. Aim We aimed to investigate temporal trends of fimbriae serotypes and vaccine antigen-expression in B. pertussis over a 23-year period in France (1996–2018). Methods Isolates (n = 2,280) were collected through hospital surveillance, capturing one third of hospitalised paediatric pertussis cases. We assayed PT, FHA and PRN production by Western blot (n = 1,428) and fimbriae production by serotyping (n = 1,058). Molecular events underlying antigen deficiency were investigated by genomic sequencing. Results The proportion of PRN-deficient B. pertussis isolates has increased steadily from 0% (0/38) in 2003 to 48.4% (31/64) in 2018 (chi-squared test for trend, p 481 insertion within the prn gene or a 22 kb genomic inversion involving the prn promoter sequence, indicative of convergent evolution. FIM2-expressing isolates have emerged since 2011 at the expense of FIM3. Conclusions B. pertussis is evolving through the rapid increase of PRN-deficient isolates and a recent shift from FIM3 to FIM2 expression. Excluding PRN, the loss of vaccine antigen expression by circulating B. pertussis isolates is epidemiologically insignificant.

Published
2021

48. Explorations microbiologiques de la sensibilité aux antibiotiques de Helicobacter pylori.

Author

Lehours, Philippe

Subjects
*MICROBIAL sensitivity tests, *HELICOBACTER pylori, *BASE isolation system, *MACROLIDE antibiotics, *CLARITHROMYCIN, *HELICOBACTER pylori infections
Abstract

Résumé: L'étude de la sensibilité de Helicobacter pylori aux antibiotiques repose sur l'isolement par culture de la bactérie à partir de biopsies gastriques. Les antibiogrammes sont réalisés par détermination des concentrations minimales inhibitrices en testant au minimum la clarithromycine et la lévofloxacine. L'alternative à la culture est de chercher au minimum par PCR les mutations associées à la résistance aux macrolides. Les PCR sur échantillons de selles ne sont pas encore au point. The study of the sensitivity of Helicobacter pylori to antibiotics is based on the isolation of the bacteria from gastric biopsies by culture. Antibiotic susceptibility tests are performed by determining the minimum inhibitory concentrations by testing at least clarithromycin and levofloxacin. The alternative to culture is to test for macrolide resistance mutations by PCR. PCR on stool samples is not yet developed. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Helicobacter pylori resistance to antibiotics in Europe in 2018 and its relationship to antibiotic consumption in the community

Author

Megraud, Francis, Bruyndonckx, Robin, Coenen, Samuel, Wittkop, Linda, Huang, Te-Din, Hoebeke, Martin, Benejat, Lucie, Lehours, Philippe, Goossens, Herman, Glupczynski, youri, European Helicobacter Pylori Antimicrobial Susceptibility Testing Working, Group, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), European Helicobacter Pylori, DARMIGNY, SANDRINE, Bordeaux Research In Translational Oncology [Bordeaux] (BaRITOn), Université de Bordeaux (UB)-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Vaccine & Infectious Disease Institute [Antwerp, Belgium] (VAXINFECTIO), University of Antwerp (UA), Hasselt University (UHasselt), Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Université Bordeaux Segalen - Bordeaux 2, Université de Bordeaux (UB), CHU UCL Namur, European Helicobacter pylori Antimicrobial Susceptibility Testing Working Group: Athanasios Makristathis, Lyudmila Boyanova, Ante Tonkic, Marija Tonkic, Leif Andersen, Benjamin Blumel, Erick Glocker, Ina Tammer, Alexander Link, Sebastian Suerbaum, Karl Dichtl, Andreas Mentis, Beatriz Marintez-Gonzales, Sinead Smith, Deirdre McNamara, Maria Pina Dore, Rosa Monno, Antonio Lippolis, Dace Rudzite, Marcis Leja, Juozas Kupcinskas, Kjetil K Melby, Grazyna Gosciniak, Tomasz M Karpinski, Monica Oleastro, Samo Jeverica, Xavier Calvet, Maria José Ramirez-Lázaro, Milagrosa Montes Ros, Ana Morilla, Sjoukje Boonstra, Peter M Schneeberger, UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Laboratoire de biologie clinique

Subjects
0301 basic medicine, medicine.medical_specialty, medicine.drug_class, [SDV]Life Sciences [q-bio], Gastric diseases, 030106 microbiology, Antibiotics, Drug resistance, antibiotics, WATER, SURVEILLANCE, ERADICATION, MULTICENTER, PREVALENCE, Helicobacter pylori infection, 03 medical and health sciences, 0302 clinical medicine, Antibiotic resistance, Levofloxacin, Clarithromycin, Internal medicine, medicine, drug resistance, biology, business.industry, Gastroenterology, gastric diseases, Helicobacter pylori, biology.organism_classification, Quinolone, bacterial infections and mycoses, 3. Good health, [SDV] Life Sciences [q-bio], Metronidazole, 030211 gastroenterology & hepatology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Human medicine, business, medicine.drug
Abstract

ObjectiveOur aim was to prospectively assess the antibiotic resistance rates in Helicobacter pylori strains in Europe in 2018 and to study the link between antibiotic consumption in the community and H. pylori resistance levels in the different countries.DesignThe proportion of primary antibiotic resistance cases of H. pylori and their corresponding risk factors were investigated in 24 centres from 18 European countries according to a standardised protocol. Data on antibiotic consumption in the community were collected for the period 2008–2017. The link between antibiotic consumption and resistance data was assessed using generalised linear mixed models. The model with the best fit was selected by means of the Akaike Information Criterion.ResultsH. pylori resistance rates for the 1211 adult patients included were 21.4% for clarithromycin, 15.8% for levofloxacin and 38.9% for metronidazole and were significantly higher in Central/Western and Southern than in the Northern European countries.The best model fit was obtained for the Poisson distribution using 2013 consumption data. A significant association was found between H. pylori clarithromycin resistance and consumption in the community of macrolides (p=0.0003) and intermediate-acting macrolides (p=0.005), and between levofloxacin resistance and consumption of quinolones (p=0.0002) and second-generation quinolones (p=0.0003).ConclusionThis study confirms the positive correlation between macrolide and quinolone consumption in the community and corresponding H. pylori resistance in European countries. Hence, H. pylori treatment with clarithromycin and levofloxacin should not be started without susceptibility testing in most European countries.

Published
2021

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