253 results on '"Li, Guo‐Bo"'
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2. TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro
3. Expanding causal genes for Parkinson’s disease via multi-omics analysis
4. Metal binding pharmacophore click-derived discovery of new broad-spectrum metallo-β-lactamase inhibitors
5. Metallo-β-lactamase-mediated antimicrobial resistance and progress in inhibitor discovery
6. New ε-N-thioglutaryl-lysine derivatives as SIRT5 inhibitors: Chemical synthesis, kinetic and crystallographic studies
7. List of contributors
8. Design, Synthesis, and Biological Evaluation of New 1H-Imidazole-2-Carboxylic Acid Derivatives as Metallo-β-Lactamase Inhibitors
9. TarKG: a comprehensive biomedical knowledge graph for target discovery.
10. Potential synthetic lethality for breast cancer: A selective sirtuin 2 inhibitor combined with a multiple kinase inhibitor sorafenib
11. Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-β-lactamase inhibitors
12. Discovery of new human Sirtuin 5 inhibitors by mimicking glutaryl-lysine substrates
13. ProfKin: A comprehensive web server for structure-based kinase profiling
14. Discovering New Metallo-Deubiquitinase CSN5 Inhibitors by a Non-Catalytic Activity Assay Platform.
15. Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery
16. X‑ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
17. Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-β-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding
18. X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells
19. ((S)-3-Mercapto-2-methylpropanamido)acetic acid derivatives as metallo-β-lactamase inhibitors: Synthesis, kinetic and crystallographic studies
20. Structure–Activity Relationship Studies of 2,4,5-Trisubstituted Pyrimidine Derivatives Leading to the Identification of a Novel and Potent Sirtuin 5 Inhibitor against Sepsis-Associated Acute Kidney Injury
21. Synthesis and evaluation of styrylpyran fluorophores for noninvasive detection of cerebral β-amyloid deposits
22. Organocatalytic Asymmetric Morita–Baylis–Hillman Reaction of Isatins with Vinyl Sulfones
23. LEADOPT: An automatic tool for structure-based lead optimization, and its application in structural optimizations of VEGFR2 and SYK inhibitors
24. Structure-Based Design of the Indole-Substituted Triazolopyrimidines as New EED–H3K27me3 Inhibitors for the Treatment of Lymphoma
25. Design, Synthesis, and Biological Evaluation of Boron-Containing β-Lactamase Inhibitors: Closed-Loop Education Experiences in an Undergraduate Medicinal Chemistry Course
26. MeDBA: the Metalloenzyme Data Bank and Analysis platform
27. A prediction model of drug-induced ototoxicity developed by an optimal support vector machine (SVM) method
28. Chapter 16 - Benzoxaborole: a privileged scaffold for drug discovery
29. Structure‐based discovery of new selective small‐molecule sirtuin 5 inhibitors
30. Deep learning in target prediction and drug repositioning: Recent advances and challenges
31. A combined molecular docking-based and pharmacophore-based target prediction strategy with a probabilistic fusion method for target ranking
32. Characterization of a novel carbapenem-hydrolysing β-lactamase OXA-1041 in Escherichia coli.
33. Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization
34. MeCOM: A Method for Comparing Three-Dimensional Metalloenzyme Active Sites
35. Design, Synthesis, and Biological Evaluation of Boron-Containing β‑Lactamase Inhibitors: Closed-Loop Education Experiences in an Undergraduate Medicinal Chemistry Course.
36. Structure-Based Design of the Indole-Substituted Triazolopyrimidines as New EED–H3K27me3 Inhibitors for the Treatment of Lymphoma.
37. MeDBA: the Metalloenzyme Data Bank and Analysis platform.
38. Targeting Metalloenzymes by Boron-Containing Metal-Binding Pharmacophores
39. Discovery of 3-aryl substituted benzoxaboroles as broad-spectrum inhibitors of serine- and metallo-β-lactamases
40. Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors
41. AncPhore: A versatile tool for anchor pharmacophore steered drug discovery with applications in discovery of new inhibitors targeting metallo-β-lactamases and indoleamine/tryptophan 2,3-dioxygenases
42. X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson’s Disease
43. Design and enantioselective synthesis of 3-(α-acrylic acid) benzoxaboroles to combat carbapenemase resistance
44. Cover Image, Volume 40, Issue 5
45. ProfKin: A Comprehensive Web Server for Structure-based Kinase Selectivity Profiling
46. Ruthenium‐Catalyzed meta ‐Selective C−H Nitration of Biologically Important Aryltetrazoles
47. Principles and current strategies targeting metallo‐β‐lactamase mediated antibacterial resistance
48. Divergent C–H activation synthesis of chalcones, quinolones and indoles
49. Discovery of mercaptopropanamide-substituted aryl tetrazoles as new broad-spectrum metallo-β-lactamase inhibitors
50. 19F‐NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo‐β‐Lactamase
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