247 results on '"Li, Guo-Bo"'
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2. Macrocyclic peptides: up-and-coming weapons to combat antimicrobial resistance
3. TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro
4. Metal binding pharmacophore click-derived discovery of new broad-spectrum metallo-β-lactamase inhibitors
5. Metallo-β-lactamase-mediated antimicrobial resistance and progress in inhibitor discovery
6. New ε-N-thioglutaryl-lysine derivatives as SIRT5 inhibitors: Chemical synthesis, kinetic and crystallographic studies
7. List of contributors
8. Design, Synthesis, and Biological Evaluation of New 1H-Imidazole-2-Carboxylic Acid Derivatives as Metallo-β-Lactamase Inhibitors
9. Potential synthetic lethality for breast cancer: A selective sirtuin 2 inhibitor combined with a multiple kinase inhibitor sorafenib
10. Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-β-lactamase inhibitors
11. X‑ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.
12. Discovery of new human Sirtuin 5 inhibitors by mimicking glutaryl-lysine substrates
13. ProfKin: A comprehensive web server for structure-based kinase profiling
14. Sensitive fluorogenic substrates for sirtuin deacylase inhibitor discovery
15. Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-β-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding
16. Structure–Activity Relationship Studies of 2,4,5-Trisubstituted Pyrimidine Derivatives Leading to the Identification of a Novel and Potent Sirtuin 5 Inhibitor against Sepsis-Associated Acute Kidney Injury
17. X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells
18. ((S)-3-Mercapto-2-methylpropanamido)acetic acid derivatives as metallo-β-lactamase inhibitors: Synthesis, kinetic and crystallographic studies
19. Organocatalytic Asymmetric Morita–Baylis–Hillman Reaction of Isatins with Vinyl Sulfones
20. Structure-Based Design of the Indole-Substituted Triazolopyrimidines as New EED–H3K27me3 Inhibitors for the Treatment of Lymphoma
21. Design, Synthesis, and Biological Evaluation of Boron-Containing β-Lactamase Inhibitors: Closed-Loop Education Experiences in an Undergraduate Medicinal Chemistry Course
22. Synthesis and evaluation of styrylpyran fluorophores for noninvasive detection of cerebral β-amyloid deposits
23. Characterization of a novel carbapenem-hydrolysing β-lactamase OXA-1041 in Escherichia coli.
24. LEADOPT: An automatic tool for structure-based lead optimization, and its application in structural optimizations of VEGFR2 and SYK inhibitors
25. MeDBA: the Metalloenzyme Data Bank and Analysis platform
26. Chapter 16 - Benzoxaborole: a privileged scaffold for drug discovery
27. A prediction model of drug-induced ototoxicity developed by an optimal support vector machine (SVM) method
28. Deep learning in target prediction and drug repositioning: Recent advances and challenges
29. Structure‐based discovery of new selective small‐molecule sirtuin 5 inhibitors
30. Design, Synthesis, and Biological Evaluation of Boron-Containing β‑Lactamase Inhibitors: Closed-Loop Education Experiences in an Undergraduate Medicinal Chemistry Course.
31. A combined molecular docking-based and pharmacophore-based target prediction strategy with a probabilistic fusion method for target ranking
32. Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization
33. Structure-Based Design of the Indole-Substituted Triazolopyrimidines as New EED–H3K27me3 Inhibitors for the Treatment of Lymphoma.
34. MeDBA: the Metalloenzyme Data Bank and Analysis platform.
35. MeCOM: A Method for Comparing Three-Dimensional Metalloenzyme Active Sites
36. Targeting Metalloenzymes by Boron-Containing Metal-Binding Pharmacophores
37. Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors
38. Discovery of 3-aryl substituted benzoxaboroles as broad-spectrum inhibitors of serine- and metallo-β-lactamases
39. AncPhore: A versatile tool for anchor pharmacophore steered drug discovery with applications in discovery of new inhibitors targeting metallo-β-lactamases and indoleamine/tryptophan 2,3-dioxygenases
40. X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson’s Disease
41. Design and enantioselective synthesis of 3-(α-acrylic acid) benzoxaboroles to combat carbapenemase resistance
42. Cover Image, Volume 40, Issue 5
43. ProfKin: A Comprehensive Web Server for Structure-based Kinase Selectivity Profiling
44. Ruthenium‐Catalyzed meta ‐Selective C−H Nitration of Biologically Important Aryltetrazoles
45. Principles and current strategies targeting metallo‐β‐lactamase mediated antibacterial resistance
46. Divergent C–H activation synthesis of chalcones, quinolones and indoles
47. Discovery of mercaptopropanamide-substituted aryl tetrazoles as new broad-spectrum metallo-β-lactamase inhibitors
48. Practical Synthesis of Benzimidazo[1,2-a]quinolines via Rh(III)-Catalyzed C–H Activation Cascade Reaction from Imidamides and Anthranils
49. MeLAD: an integrated resource for metalloenzyme-ligand associations
50. 19F‐NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo‐β‐Lactamase
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