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271 results on '"Liakakos, Theodoros"'

5. Consensus statement of the Hellenic and Cypriot Gastric Cancer Study Group on the diagnosis, staging and management of gastric cancer

Author

Douridas, Gerasimos N., Fountoulakis, Andreas, Souglakos, John, Gourtsoyianni, Sofia, Vini, Louiza, Levidou, Georgia, Liakakos, Theodoros, Agalianos, Christos, Dervenis, Christos, Kalogeridi, Maria Angeliki, Karavokyros, Ioannis, Koumarianou, Anna, Kountourakis, Panteleimon, Oikonomopoulos, Georgios, Economopoulou, Panagiota, Sgouros, Joseph, Sgouros, Spiros N., Stamou, Konstantinos, Triantopoulou, Charikleia, Zacharoulis, Dimitrios, Gouvas, Nikolaos, and Xynos, Evangelos

Published
2020
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6. Consensus statement of the Hellenic and Cypriot Oesophageal Cancer Study Group on the diagnosis, staging and management of oesophageal cancer

Author

Fountoulakis, Andreas, Souglakos, John, Vini, Louiza, Douridas, Gerasimos N., Koumarianou, Anna, Kountourakis, Panteleimon, Agalianos, Christos, Alexandrou, Andreas, Dervenis, Christos, Gourtsoyianni, Sofia, Gouvas, Nikolaos, Kalogeridi, Maria-Angeliki, Levidou, Georgia, Liakakos, Theodoros, Sgouros, Joseph, Sgouros, Spiros N., Triantopoulou, Charikleia, and Xynos, Evangelos

Published
2019
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8. #1007 Comparing the use of MRNA high risk HPV and HPV DNA test combined with liquid based cytology as primary screening tool for cervical cancer (preliminary results)

Author

Papakonstantinou, Aikaterini, primary, Panagakis, George, additional, Liakakos, Theodoros, additional, Sotirchos, Athanasios, additional, Karaiskou, Akrivi, additional, Papageorgiou, Dimitris, additional, Petrogiannis, Savvas, additional, Petrogiannis, Nikolaos, additional, and Trachanas, Dimitrios, additional

Published
2023
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10. The Expression Patterns and Implications of MALAT1 , MANCR , PSMA3-AS1 and miR-101 in Esophageal Adenocarcinoma.

Author

Syllaios, Athanasios, Gazouli, Maria, Vailas, Michail, Mylonas, Konstantinos S., Sakellariou, Stratigoula, Sougioultzis, Stavros, Karavokyros, Ioannis, Liakakos, Theodoros, and Schizas, Dimitrios

Subjects
NON-coding RNA, LINCRNA, PROGNOSIS, ADENOCARCINOMA, LYMPH nodes, LYMPHATIC metastasis
Abstract

Esophageal adenocarcinoma (EAC) is a malignant tumor with poorly understood molecular mechanisms. This study endeavors to elucidate how the long non-coding RNAs (lncRNAs) MALAT1, MANCR and PSMA3-AS1, as well as the microRNA miR-101, exhibit specific expression patterns in the pathogenesis and prognosis of EAC. A total of 50 EAC tissue samples (tumors and lymph nodes) and a control group comprising 26 healthy individuals were recruited. The samples underwent quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analyses. The relative expression levels of MALAT1, MANCR, PSMA3-AS1, and miR-101 were ascertained and correlated with various clinicopathological parameters including TNM staging, tumor characteristics (size and grade of the tumor) lymphatic invasion, disease-free (DFS) and overall survival (OS) of EAC patients. Quantitative analyses revealed that MALAT1 and MANCR were significantly upregulated in EAC tumors and positive lymph nodes when compared to control tissues (p < 0.05). Such dysregulations correlated positively with advanced lymphatic metastases and a higher N stage. DFS in the subgroup of patients with negative lymph nodes was higher in the setting of low-MANCR-expression patients compared to patients with high MANCR expression (p = 0.02). Conversely, miR-101 displayed a significant downregulation in EAC tumors and positive lymph nodes (p < 0.05), and correlated negatively with advanced tumor stage, lymphatic invasion and the grade of the tumor (p = 0.006). Also, patients with low miR-101 expression showed a tendency towards inferior overall survival. PSMA3-AS1 did not demonstrate statistically significant alterations (p > 0.05). This study reveals MALAT1, MANCR, and miR-101 as putative molecular markers for prognostic evaluation in EAC and suggests their involvement in EAC progression. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Gastrectomy for Cancer: A 15-Year Analysis of Real-World Data from the University of Athens

Author

Schizas, Dimitrios, primary, Mylonas, Konstantinos S., additional, Syllaios, Athanasios, additional, Kapetanakis, Emmanouil I., additional, Hasemaki, Natasha, additional, Ntomi, Vasileia, additional, Michalinos, Adamantios, additional, Theochari, Nikoletta A., additional, Theochari, Christina A., additional, Krivan, Sylvia, additional, Mpoura, Maria, additional, Bakopoulos, Anargyros, additional, Karavokyros, Ioannis, additional, and Liakakos, Theodoros, additional

Published
2022
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21. 587. ROLE OF THORACOSCOPIC HAND-SEWN ESOPHAGO-GASTRIC ANASTOMOSIS IN 2-STAGE TOTALLY MINIMALLY INVASIVE ESOPHAGECTOMY. REPORT OF 200 CONSECUTIVE CASES

Author

Davakis, Spyridon, primary, Liakakos, Theodoros, additional, Sakellariou, Stratigoula, additional, Ziogas, Dimitrios, additional, Theochari, Maria, additional, Ntoka, Polyxeni, additional, Stratigopoulou, Panagiota, additional, Mpaili, Efstatia, additional, and Charalabopoulos, Alexandros, additional

Published
2022
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27. The Role of Toll-like Receptors in Esophageal Cancer

Author

DAVAKIS, SPYRIDON, primary, KAPELOUZOU, ALKISTIS, additional, LIAKAKOS, THEODOROS, additional, MPOURA, MARIA, additional, STERGIOU, DIMITRIOS, additional, SAKELLARIOU, STRATIGOULA, additional, and CHARALABOPOULOS, ALEXANDROS, additional

Published
2022
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29. Growth of Intestinal Neomucosa on Pedicled Gastric Wall Flap, a Novel Technique in an Animal Model

Author

Sakarellos, Panagiotis, primary, Papalois, Apostolos, additional, Gakiopoulou, Harikleia, additional, Zacharioudaki, Iro, additional, Katsimpoulas, Michalis, additional, Belia, Marina, additional, Moris, Dimitrios, additional, Aggelou, Kyveli, additional, Vagios, Ilias, additional, Davakis, Spiridon, additional, Vailas, Michail, additional, Liakakos, Theodoros, additional, Diamantis, Theodoros, additional, Felekouras, Evangelos, additional, and Kontos, Michael, additional

Published
2022
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30. Alterations in Toll-Like Receptor 7 and -9 mRNA Levels in Lungs after Ovariohysterectomy in a Pyometra Mouse Model

Author

Kyriakopoulos, Konstantinos, primary, Katsimpoulas, Michael, additional, Mylonas, Konstantinos S., additional, Lidoriki, Irene, additional, Ziogas, Ioannis A., additional, Perivolioti, Efstathia P., additional, Stamataki, Despoina K., additional, Chrelias, Charalampos, additional, Schizas, Dimitrios, additional, Alexandrou, Andreas, additional, Liakakos, Theodoros, additional, and Kapelouzou, Alkistis, additional

Published
2021
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35. Gastrointestinal Stromal Tumor With chondrosarcomatous Dedifferentiation Following Imatinib Therapy

Author

Koufopoulos, Nektarios Zacharatou, Andriani Athanasiadou, Sophia and Tomos, Periklis Ekonomopoulou, Panagiota Liakakos, Theodoros and Panayiotides, Ioannis G.

Subjects
hemic and lymphatic diseases, neoplasms, digestive system diseases
Abstract

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the digestive tract, followed by schwannomas, lipomas, leiomyomas, and vascular tumors. They arise more often in the stomach, followed by the small bowel, esophagus, and rectum. Imatinib mesylate, a tyrosine kinase inhibitor with activity against ABL, BCR-ABL, platelet-derived growth factor receptor-alpha (PDGFRA), and c-KIT (CD117), constitutes the cornerstone of treatment for inoperable or metastatic GIST. Cases showing disease progression or resistance to imatinib mesylate may retain their morphology or present unusual morphologic and immunohistochemical characteristics. We herein describe a case of a 67-year-old patient with a previous history of GIST of the stomach, with local recurrence, who was admitted with a workup of lung nodule on chest computed tomography as part of the routine follow-up. The nodule was resected which showed a malignant tumor composed of epithelioid cells, with an abrupt transition to chondrosarcoma. Epithelioid cells were immunostained for CD117, DOG1, and Vimentin, whereas chondrosarcomatous cells expressed only Vimentin. These findings were consistent with metachronous pulmonary metastasis of the previously diagnosed GIST with chondrosarcomatous dedifferentiation. No KIT or PDGFRA mutation was detected. A review of all accessible pertinent papers disclosed 26 similar cases with unusual morphological and immunohistochemical findings, either postimatinib treatment or, less commonly, de novo, with heterogeneous differentiation. Awareness of the histological and immunohistochemical changes in GISTs post imatinib therapy is essential to avoid a severe diagnostic pitfall.

Published
2021

41. Postoperative Changes in Nutritional and Functional Status of Gastroesophageal Cancer Patients.

Author

Lidoriki, Irene, Schizas, Dimitrios, Mylonas, Konstantinos S., Vergadis, Chrysovalantis, Karydakis, Lysandros, Alexandrou, Andreas, Karavokyros, Ioannis, and Liakakos, Theodoros

Abstract

Objective: Disease-related malnutrition is a debilitating condition frequently observed in patients with cancer. The aim of the current study was to prospectively examine postoperative changes in nutritional and functional status of patients undergoing surgery for gastric, esophageal, and gastroesophageal junction cancer. Methods: Participants were prospectively recruited from September 2015 to September 2019. The assessment of malnutrition was based on the Patient-Generated Subjective Global Assessment tool. The functional assessment included the evaluation of muscle strength and physical performance, while muscle mass assessment was based on Skeletal Muscle Mass Index (SMI) derived from the analysis of computed tomography scans. The follow up of patients was scheduled at six months postoperatively. Results: A total of 98 patients were analyzed. Mean patient age was 60.79 ± 10.19 years and 80.6% were males. The mean unintentional weight loss at 6months was 11.7 ± 8.0%. Patients who underwent McKeown esophagectomy reported the greatest weight loss postoperatively (16.2 ± 9.6%), whereas the lowest rate of weight loss was observed in patients who underwent partial gastrectomy (5.6 ± 6.7%). The rate of severe malnutrition declined at six months postoperatively (39.7% vs 27%). Muscle strength and physical performance were significantly deteriorated at 6months postoperatively, except for the group of partial gastrectomy, while SMI significantly decreased in all groups of patients except for McKewon esophagectomy group. Finally, the prevalence of low muscle mass increased significantly from 43.5% in the preoperative period to 66.7% at the follow-up. Conclusions: Our study revealed a significant deterioration in gastroesophageal cancer patient nutritional and functional status at six months postoperatively. The high prevalence of malnutrition and low muscle mass requires systematic follow-up and multidirectional monitoring in order to ensure the successful rehabilitation of these patients. [ABSTRACT FROM AUTHOR]

Published
2022
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42. Alterations in Toll-Like Receptor 7 and -9 mRNA Levels in Lungs after Ovariohysterectomy in a Pyometra Mouse Model.

Author

Kyriakopoulos, Konstantinos, Katsimpoulas, Michael, Mylonas, Konstantinos S., Lidoriki, Irene, Ziogas, Ioannis A., Perivolioti, Efstathia P., Stamataki, Despoina K., Chrelias, Charalampos, Schizas, Dimitrios, Alexandrou, Andreas, Liakakos, Theodoros, and Kapelouzou, Alkistis

Subjects
TOLL-like receptors, NF-kappa B, LABORATORY mice, PYOMETRA, ANIMAL disease models
Abstract

Background: Pyometra (P) leads to sepsis and multiple organ dysfunction syndrome. Toll-like receptors (TLRs) recognize pathogens which can cause P. The aim of this study was to investigate TLR-7 and -9 via the MYD88 pathway and the nuclear factor kappa B (NFκB) response in the uterus of a P mouse model before and after ovariohysterectomy (RP) as well as potential lung injury. Materials and Methods: 200 female C57BL/6J mice were randomly divided into groups (N = 10/subgroup; sham 1, 2, 3, 7; P1, 2, 3, 7; 1RP1, 2, 3, 7; 2RP1, 2, 3, 7; 3RP1, 2, 3, 7) according to the day of euthanasia. Pathogens were administrated in the groups P and RP in order to induce P. Results: Alterations in blood chemistry, histopathology, and RT-qPCT analysis before (P) and after RP were observed. Significant correlations were also found between MYD88, NFκB, and TLR9 in P and RP groups in the lungs and in RP groups in the uterus, suggesting that the immune system responded via the TLR9-MYD88 pathway. Conclusions: This is the first report of immunohistochemical TLR-7 and -9 localization and of TLR-7, -9, MYD88, and NFκB mRNA expression in the uterus causing lung injury in a P mouse model. [ABSTRACT FROM AUTHOR]

Published
2022
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44. 202 In vitro and in vivo combination therapy of Low Molecular Weight Heparins, chemotherapy and immunotherapy, induce antitumor activity in Pancreatic Cancer

Author

Karamouzis, Michalis, primary, Karamouzis, Michalis, additional, Sarantis, Panagiotis, additional, Koustas, Evangelos, additional, Papadimitropoulou, Adriana, additional, Papakotoulas, Pavlos, additional, Bokas, Alexandros, additional, Schizas, Dimitrios, additional, Papalampros, Alexandros, additional, Felekouras, Evangelos, additional, Liakakos, Theodoros, additional, and Papavassiliou, Athanasios, additional

Published
2020
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45. Esophageal cancer surgery in Greece during the era of the financial crisis

Author

Schizas, Dimitrios, primary, Mylonas, Konstantinos S, additional, Hasemaki, Natasha, additional, Mpaili, Efstratia, additional, Ntomi, Vasileia, additional, Michalinos, Adamantios, additional, Theochari, Nikoletta A, additional, Theochari, Christina A, additional, Mpoura, Maria, additional, Bakopoulos, Anargyros, additional, and Liakakos, Theodoros, additional

Published
2020
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47. Inflammation and Immunotherapy in Atherosclerosis

Author

Mylonas, Konstantinos S., primary, Kapelouzou, Alkistis, additional, Spartalis, Michael, additional, Schizas, Dimitrios, additional, Spartalis, Eleftherios, additional, Bakoyiannis, Christos, additional, Iliopoulos, Dimitrios, additional, Liakakos, Theodoros, additional, and Nikiteas, Nikolaos, additional

Published
2020
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50. Expression of ZO Proteins in Benign Nevi and Skin Malignant Melanoma

Author

Lakiotaki, Eleftheria, primary, Delicostantinou, Irakles, additional, Basios, Neofytos, additional, Tsimpoukelis, Antonis, additional, Chelidonis, Georgios, additional, Dimitriou, Nikoleta, additional, Griniatsos, John, additional, Kyros, Eleandros, additional, Tsechpenakis, Anastasios, additional, Liakakos, Theodoros, additional, and Karavokyros, Ioannis, additional

Published
2020
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