7 results on '"Liane LaDouceur"'
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2. Highly stable hierarchically structured all-polymeric lubricant-infused films prevent blood stains and repel multi drug-resistant pathogens
- Author
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Elisabet Afonso, Fereshteh Bayat, Liane Ladouceur, Shadman Khan, Aránzazu Martínez-Gómez, Jeffrey Weitz, Zeinab Hosseinidoust, Pilar Tiemblo, Nuria García, and Tohid Didar
- Abstract
Thrombus formation and infections caused by bacterial adhesion are the most common causes of failure in blood-contacting medical devices. Reducing interaction of pathogens by using repellent surfaces has proven to be a successful strategy in preventing device failure. However, designing scale-up methodologies to create large scale repellent surfaces remains challenging. To address this need, we have created an all-polymeric lubricant-infused system using an industrially viable swelling-coagulation solvent (S-C) method. This induces hierarchically structured micro/nano features onto the surface, enabling improved lubricant-infusion. Poly(3,3,3 - trifluoropropylmethylsiloxane) (PTFS) was used as the lubricant of choice, a previously unexplored omniphobic non-volatile silicone oil. This resulted in all-polymeric liquid-infused surfaces that are transparent and flexible with long-term stability. Repellent properties have been demonstrated using human whole blood and methicillin-resistant Staphyloccus aureus (MRSA) bacteria matrices, with lubricated surfaces showing 93% reduction in blood stains and 96.7% reduction in bacterial adherence. The developed material has the potential to prevent blood and pathogenic contamination for a range of biomedical devices within healthcare settings.
- Published
- 2022
- Full Text
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3. Producing Fluorine- and Lubricant-Free Flexible Pathogen- and Blood-Repellent Surfaces Using Polysiloxane-Based Hierarchical Structures
- Author
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Liane Ladouceur, Amid Shakeri, Shadman Khan, Alejandra Rey Rincon, Esra Kasapgil, Jeffrey I. Weitz, Leyla Soleymani, and Tohid F. Didar
- Subjects
Siloxanes ,Surface Properties ,Materials Testing ,Escherichia coli ,General Materials Science ,Biocompatible Materials ,Microbial Sensitivity Tests ,Particle Size ,Anti-Bacterial Agents - Abstract
High-touch surfaces are known to be a major route for the spread of pathogens in healthcare and public settings. Antimicrobial coatings have, therefore, garnered significant attention to help mitigate the transmission of infectious diseases
- Published
- 2022
4. Highly Stable Hierarchically Structured All-Polymeric Lubricant-Infused Films Prevent Thrombosis and Repel Multidrug-Resistant Pathogens
- Author
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Elisabet Afonso, Fereshteh Bayat, Liane Ladouceur, Shadman Khan, Aránzazu Martínez-Gómez, Jeffrey I. Weitz, Zeinab Hosseinidoust, Pilar Tiemblo, Nuria García, Tohid F. Didar, Ministerio de Ciencia e Innovación (España), Canada Research Chairs, and University of Ontario
- Subjects
Methicillin-Resistant Staphylococcus aureus ,liquid-infused surfaces, omniphobic lubricant, hierarchically structured surfaces, antibacterial, antithrombogenic ,Blood Stains ,Humans ,General Materials Science ,Lubricants - Abstract
Thrombus formation and infections caused by bacterial adhesion are the most common causes of failure in blood-contacting medical devices. Reducing the interaction of pathogens using repellent surfaces has proven to be a successful strategy in preventing device failure. However, designing scale-up methodologies to create large-scale repellent surfaces remains challenging. To address this need, we have created an all-polymeric lubricant-infused system using an industrially viable swelling-coagulation solvent (S-C) method. This induces hierarchically structured micro/nano features onto the surface, enabling improved lubricant infusion. Poly(3,3,3-trifluoropropylmethylsiloxane) (PTFS) was used as the lubricant of choice, a previously unexplored omniphobic nonvolatile silicone oil. This resulted in all-polymeric liquid-infused surfaces that are transparent and flexible with long-term stability. Repellent properties have been demonstrated using human whole blood and methicillin-resistant Staphylococcus aureus (MRSA) bacteria matrices, with lubricated surfaces showing 93% reduction in blood stains and 96.7% reduction in bacterial adherence. The developed material has the potential to prevent blood and pathogenic contamination for a range biomedical devices within healthcare settings., E.A. thanks Spanish Ministry of Science and Innovation for the FPI Grant (BES-2017-080057). T.F.D. acknowledges support from NSERC Discovery Grant, Ontario Early Researcher Award and McMaster Start-up funds to T.F.D. T.F.D and Z.H.D are Tier II Canada Research Chairs.
- Published
- 2022
5. Transparent and Highly Flexible Hierarchically Structured Polydimethylsiloxane Surfaces Suppress Bacterial Attachment and Thrombosis Under Static and Dynamic Conditions
- Author
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Shadman Khan, Noor Abu Jarad, Liane Ladouceur, Kenneth Rachwalski, Veronica Bot, Amid Shakeri, Roderick Maclachlan, Sadman Sakib, Jeffrey I. Weitz, Eric D. Brown, Leyla Soleymani, and Tohid F. Didar
- Subjects
Biomaterials ,Methicillin-Resistant Staphylococcus aureus ,Surface Properties ,Biofilms ,Humans ,General Materials Science ,Thrombosis ,General Chemistry ,Dimethylpolysiloxanes ,Bacterial Adhesion ,Biotechnology - Abstract
The surface fouling of biomedical devices has been an ongoing issue in healthcare. Bacterial and blood adhesion in particular, severely impede the performance of such tools, leading to poor patient outcomes. Various structural and chemical modifications have been shown to reduce fouling, but all existing strategies lack the combination of physical, chemical, and economic traits necessary for widespread use. Herein, a lubricant infused, hierarchically micro- and nanostructured polydimethylsiloxane surface is presented. The surface is easy to produce and exhibits the high flexibility and optical transparency necessary for incorporation into various biomedical tools. Tests involving two clinically relevant, priority pathogens show up to a 98.5% reduction in the biofilm formation of methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. With blood, the surface reduces staining by 95% and suppresses thrombin generation to background levels. Furthermore, the surface shows applicability within applications such as catheters, extracorporeal circuits, and microfluidic devices, through its effectiveness in dynamic conditions. The perfusion of bacterial media shows up to 96.5% reduction in bacterial adhesion. Similarly, a 95.8% reduction in fibrin networks is observed following whole blood perfusion. This substrate stands to hold high applicability within biomedical systems as a means to prevent fouling, thus improving performance.
- Published
- 2021
6. Antimicrobial Nanomaterials and Coatings: Current Mechanisms and Future Perspectives to Control the Spread of Viruses Including SARS-CoV-2
- Author
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Leyla Soleymani, Tohid F. Didar, Terrel Marshall, Liane Ladouceur, Sara M. Imani, and Roderick Maclachlan
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2019-20 coronavirus outbreak ,Virus inactivation ,Coronavirus disease 2019 (COVID-19) ,Emerging technologies ,Computer science ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Pneumonia, Viral ,General Physics and Astronomy ,Nanotechnology ,02 engineering and technology ,Review ,010402 general chemistry ,01 natural sciences ,Antiviral Agents ,Betacoronavirus ,Humans ,General Materials Science ,Pandemics ,Personal Protective Equipment ,nanocoatings ,SARS-CoV-2 ,General Engineering ,antiviral surfaces ,COVID-19 ,photoactive materials ,021001 nanoscience & nanotechnology ,Antimicrobial ,0104 chemical sciences ,Nanostructures ,virus repellent ,pathogen-repellent surfaces ,virus inactivation ,antimicrobial coatings ,engineered surfaces ,0210 nano-technology ,Coronavirus Infections - Abstract
The global COVID-19 pandemic has attracted considerable attention toward innovative methods and technologies for suppressing the spread of viruses. Transmission via contaminated surfaces has been recognized as an important route for spreading SARS-CoV-2. Although significant efforts have been made to develop antibacterial surface coatings, the literature remains scarce for a systematic study on broad-range antiviral coatings. Here, we aim to provide a comprehensive overview of the antiviral materials and coatings that could be implemented for suppressing the spread of SARS-CoV-2 via contaminated surfaces. We discuss the mechanism of operation and effectivity of several types of inorganic and organic materials, in the bulk and nanomaterial form, and assess the possibility of implementing these as antiviral coatings. Toxicity and environmental concerns are also discussed for the presented approaches. Finally, we present future perspectives with regards to emerging antimicrobial technologies such as omniphobic surfaces and assess their potential in suppressing surface-mediated virus transfer. Although some of these emerging technologies have not yet been tested directly as antiviral coatings, they hold great potential for designing the next generation of antiviral surfaces.
- Published
- 2020
7. Comparison of the MK-801-induced increase in non-rewarded appetitive responding with dopamine agonists and locomotor activity in rats
- Author
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Parnell L Davis-MacNevin, Matthew R. Holahan, Jordan DeKraker, and Liane LaDouceur
- Subjects
Male ,medicine.medical_specialty ,Apomorphine ,medicine.drug_class ,Perseveration ,Dopamine ,Motor Activity ,Receptors, N-Methyl-D-Aspartate ,Piperazines ,Extinction, Psychological ,Cocaine ,Internal medicine ,medicine ,Animals ,Pharmacology (medical) ,Rats, Long-Evans ,Pharmacology ,Extinction (psychology) ,Receptor antagonist ,medicine.disease ,Rats ,Psychiatry and Mental health ,Endocrinology ,Dopamine receptor ,Schizophrenia ,Dopamine Agonists ,NMDA receptor ,medicine.symptom ,Dizocilpine Maleate ,Psychology ,Neuroscience ,medicine.drug - Abstract
Systemic administration of the noncompetitive N-methyl-D-aspartate (NMDA)- receptor antagonist, MK-801, has been proposed to model cognitive deficits similar to those seen in patients with schizophrenia. Evidence has shown that MK-801 increases the probability of operant responding during extinction, possibly modeling perseveration, as would be seen in patients with schizophrenia. This MK-801-induced behavioral perseveration is reversed by dopamine receptor antagonism. To further explore the role of dopamine in this behavioral change, the current study sought to determine if the MK-801-induced increase in non-rewarded operant responding could be mimicked by dopamine agonism and determine how it was related to locomotor activity. Male Long Evans rats were treated systemically with MK-801, cocaine, GBR12909 or apomorphine (APO) and given a single trial operant extinction session, followed by a separate assessment of locomotor activity. Both MK-801 (0.05 mg/kg) and cocaine (10 mg/kg) significantly increased responding during the extinction session and both increased horizontal locomotor activity. No dose of GBR-12909 (5, 10 or 20 mg/kg) was found to effect non-rewarded operant responding or locomotor activity. APO (0.05, 0.5, 2 or 5 mg/kg) treatment produced a dose-dependent decrease in both operant responding and locomotor activity. These results suggest the possibility that, rather than a primary influence of increased dopamine concentration on elevating bar-pressing responses during extinction, other neurotransmitter systems may be involved.
- Published
- 2013
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