1. Age-dependent effect of susceptibility factors on the risk of intracerebral haemorrhage: Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy)
- Author
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Martina Locatelli, Rosa Musolino, Monica Acciarresi, Paolo La Spina, Valentina Saba, Sonia Bonacina, Mauro Magoni, Cristiano Azzini, Mario Grassi, Giovanni de Gaetano, Debora Pezzini, Cinzia Finocchi, Alessandro De Vito, Giampaolo Tomelleri, Domenico Marco Bonifati, Augusto Di Castelnuovo, Giorgio Silvestrelli, Massimo Del Sette, Francesco Grillo, Simona Marcheselli, Corrado Lodigiani, Alfonso Ciccone, Marialuisa Zedde, Andrea Zini, Lucia Princiotta Cariddi, Rocco Salvatore Calabrò, Andrea Morotti, Alessandro Pezzini, Carlo Gandolfo, Marco Ritelli, Massimo Gamba, Licia Iacovello, Anna Cavallini, Giuseppe Martini, Maurizio Paciaroni, Marina Colombi, Maria Luisa DeLodovici, Alberto Chiti, Alessia Giossi, Rossana Tassi, Valentina Mazzoleni, Alessandro Padovani, and Antonella Toriello
- Subjects
Male ,Risk ,medicine.medical_specialty ,Databases, Factual ,Age dependent ,030204 cardiovascular system & hematology ,Logistic regression ,cerebrovascular ,stroke ,Stroke risk ,Databases ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Internal medicine ,80 and over ,medicine ,Humans ,Stroke ,Factual ,Aged ,Cerebral Hemorrhage ,Aged, 80 and over ,business.industry ,Incidence ,Age Factors ,Middle Aged ,medicine.disease ,Case-Control Studies ,Female ,Italy ,Psychiatry and Mental health ,Quartile ,Multicenter study ,Surgery ,Alcohol intake ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
ObjectiveTo investigate the age-dependent impact of traditional stroke risk factors on the occurrence of intracerebral haemorrhage (ICH).MethodsWe performed a case–control analysis, comparing consecutive patients with ICH with age-matched and sex-matched stroke-free controls, enrolled in the setting of the Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy) between 2002 and 2014 by multivariable logistic regression model within subgroups stratified by age quartiles (Q1–Q4).ResultsWe analysed 3492 patients and 3492 controls. The impact of untreated hypertension on the risk of ICH was higher in the lower than in the upper age quartile (OR 11.64, 95% CI 7.68 to 17.63 in Q1 vs OR 6.05, 95% CI 3.09 to 11.85 in Q4 with intermediate ORs in Q2 and Q3), while the opposite trend was observed for untreated hypercholesterolaemia (OR 0.63, 95% CI 0.45 to 0.97 in Q1 vs OR 0.36, 95% CI 0.26 to 0.56 in Q4 with intermediate ORs in Q2 and Q3). The effect of untreated diabetes and excessive alcohol intake was detected only in the older age group (OR 3.63, 95% CI 1.22 to 10.73, and OR 1.69, 95% CI 1.13 to 2.51, respectively).ConclusionsOur findings provide evidence of age-dependent differences in the effects of susceptibility factors on the risk of ICH.
- Published
- 2021