172 results on '"Light, David R."'
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2. MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease
3. Augmentative & Alternative Communication: Supporting Children and Adults with Complex Communication Needs
4. SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells
5. VLA-4 blockade by natalizumab inhibits sickle reticulocyte and leucocyte adhesion during simulated blood flow
6. SGK1 Inhibition Induces Fetal Hemoglobin in Erythroid Cells
7. Development of a Homogeneous Time-Resolved Fluorescence Leukotriene B4 Assay for Determining the Activity of Leukotriene A4 Hydrolase
8. Obligate multivalent recognition of cell surface tomoregulin following selection from a multivalent phage antibody library
9. Crystal structures of two potent nonamidine inhibitors bound to factor Xa
10. Preparation, characterization, and the crystal structure of the inhibitor ZK-807834 (CI-1031) complexed with factor Xa
11. Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex
12. MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease
13. Genetic Activation of NRF2 By KEAP1 Inhibition Induces Fetal Hemoglobin Expression and Triggers Anti-Oxidant Stress Response in Erythroid Cells
14. Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice
15. Discovery and characterization of a potent and selective non-amidine inhibitor of human factor Xa
16. Can natural variation in erythroid microRNA‐29b be translated to sickle cell disease severity?
17. LC-MS Analysis of Anti-Sickling Compounds in Cord Blood Derived RBCs Demonstrates Modification of Fetal Hemoglobin and Globin Chain Binding Preferences
18. Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease
19. Nrf2 Activation and Fetal Hemoglobin Induction in Sickle Cell Disease
20. Conformation of a bound inhibitor of blood coagulant factor Xa
21. Prolonged Half-Life and Improved Recovery of Recombinant Factor IX-XTEN Fusion Proteins in Hemophilia B Mouse Model
22. Dimethyl Fumarate Induces Fetal Hemoglobin in Sickle Cell Disease
23. Evaluation of the toxicology and pharmacokinetics of recombinant factor VIII Fc fusion protein in animals
24. Evaluation of the toxicology, pharmacokinetics, and local tolerance of recombinant factor IX Fc fusion protein in animals
25. FcRn Rescues Recombinant Factor VIII Fc Fusion Protein from a VWF Independent FVIII Clearance Pathway in Mouse Hepatocytes
26. Enhancing the Acute Hemostatic Efficacy in Cynomolgus Monkeys By Targeting Activated Coagulation Factor VII to Platelets
27. Natalizumab Blocks VLA-4 Mediated Red Blood Cell Adhesion and Is a Potential Therapy for Sickle Cell Disease
28. THERMODYNAMIC AND KINETIC PROPERTIES OF THE ADRENOCORTICAL MITOCHONDRIAL CYTOCHROME P450 WHICH CONVERTS CHOLESTEROL INTO PREGNENOLONE
29. Immunohistochemical Staining of rFVIIIFc and rFVIII in Liver Cells Differentiates Between a VWF-Dependent and Independent Clearance Pathway in Mice
30. An Immunodeficient Mouse Model With Circulating Human Platelets To Evaluate The Platelet Clearance and Pharmacokinetics Of Platelet-Targeted Coagulation Factor VIIa
31. Structural Comparability Between Recombinant FVIII-Fc and Its Isolated FVIII and Fc Constituents
32. Different Contribution of Hematopoietic and Somatic Cell Types Expressing FcRn to the Prolonged Half-Life of Recombinant Factor VIII Fc and Recombinant FIX Fc
33. Cellular Uptake of rFVIIIFc in Liver Is Primarily Contributed by Sinusoidal Endothelial Cells.
34. In Vivo Biodistribution, PET Imaging, and Tumor Accumulation of 86Y- and 111In-Antimindin/RG-1, Engineered Antibody Fragments in LNCaP Tumor–Bearing Nude Mice
35. Monoclonal antibody therapeutics: Leading companies to maximise sales and market share
36. Monoclonal antibody therapeutics: Leading companies to maximise sales and market share
37. Obligate Multivalent Recognition of Cell Surface Tomoregulin following Selection from a Multivalent Phage Antibody Library
38. Anti-EphA2 Antibodies Decrease EphA2 Protein Levels in Murine CT26 Colorectal and Human MDA-231 Breast Tumors But Do Not Inhibit Tumor Growth
39. The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex
40. Cloning and characterization of the rat HIF-1α prolyl-4-hydroxylase-1 gene
41. Fasudil, a Rho-Kinase Inhibitor, Attenuates Angiotensin II–Induced Abdominal Aortic Aneurysm in Apolipoprotein E–Deficient Mice by Inhibiting Apoptosis and Proteolysis
42. Solid-phase synthesis of naphthylamidines as factor VIIa/tissue factor inhibitors
43. Human Factor Xa Bound Amidine Inhibitor Conformation by Double Rotational-Echo Double Resonance Nuclear Magnetic Resonance and Molecular Dynamics Simulations
44. Human in vitro pharmacodynamic profile of the selective Factor Xa inhibitor ZK-807834 (CI-1031)
45. FXa-Induced Responses in Vascular Wall Cells are PAR-Mediated and Inhibited by ZK-807834
46. An Inhibitor of Activated Thrombin-Activatable Fibrinolysis Inhibitor Potentiates Tissue-Type Plasminogen Activator-Induced Thrombolysis in a Rabbit Jugular Vein Thrombolysis Model
47. Effects of ZK-807834, a Novel Inhibitor of Factor Xa, on Arterial and Venous Thrombosis in Rabbits
48. Synthesis, Characterization, and Structure−Activity Relationships of Amidine-Substituted (Bis)benzylidene-Cycloketone Olefin Isomers as Potent and Selective Factor Xa Inhibitors
49. Conformations of Trypsin-Bound Amidine Inhibitors of Blood Coagulant Factor Xa by Double REDOR NMR and MD Simulations
50. Crystallographic analysis of potent and selective factor Xa inhibitors complexed to bovine trypsin
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