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Background: Publication activity in the field of anesthesiology informs decisions that enhance academic advancement. Most previous bibliometric studies on anesthesiology examined data limited to journals focused on anesthesiology rather than data answerable to authors in anesthesia departments. This study comprehensively explored publication trends in the field of anesthesiology and their impact. We hypothesized that anesthesiology's bibliometric scene would differ based on whether articles in the same study period were published in anesthesiology-focused journals or were produced by authors in anesthesia departments but published in non-specialty journals.Methods: This cross-sectional study used bibliometric data from the Science Citation Index Expanded database between 1999 and 2018. Two datasets were assembled. The first dataset was a subject-dataset (articles published in 31 journals in the anesthesiology category of InCites Journal Citation Reports in 2018); the second dataset was the department-dataset (articles published in the Science Citation Index Expanded by authors in anesthesia departments). We captured the bibliographical record of each article in both datasets and noted each article's Institute for Scientific Information code, publication year, title, abstract, author addresses, subject category, and references for further study.Results: A total of 69,593 articles were published—cited 1,497,932 times—in the subject-dataset; a total of 167,501 articles were published—cited 3,731,540 times—in the department-dataset. The results demonstrate differences between the two datasets. First, the number of articles was stagnant, with little growth (average annual growth rate = 0.31%) in the subject-dataset; whereas there was stable growth (average annual growth rate = 4.50%) in articles in the department-dataset. Second, only 30.4% of anesthesia department articles were published in anesthesiology journals. Third, journals related to “pain” had the lowest department-subject ratio, which was attributable to a large portion of non-anesthesia department researchers' participation in related research.Conclusions: This study showed that articles published in anesthesiology-focused and non-specialty journals demonstrate fundamentally different trends. Thus, it not only helps researchers develop a more comprehensive understanding of the current publication status and trends in anesthesiology, but also provides a basis for national academic organizations to frame relevant anesthesiology development policies and rationalize resource allocation.

Designing highly conducting metal–organic frameworks (MOFs) is currently a subject of great interest for their potential applications in diverse areas encompassing energy storage and generation. Herein, a strategic design in which a metal–sulfur plane is integrated within a MOF to achieve high electrical conductivity, is successfully demonstrated. The MOF {[Cu2(6-Hmna)(6-mn)]·NH4}n (1, 6-Hmna = 6-mercaptonicotinic acid, 6-mn = 6-mercaptonicotinate), consisting of a two dimensional (–Cu–S–)n plane, is synthesized from the reaction of Cu(NO3)2, and 6,6′-dithiodinicotinic acid via the in situ cleavage of an S–S bond under hydrothermal conditions. A single crystal of the MOF is found to have a low activation energy (6 meV), small bandgap (1.34 eV) and a highest electrical conductivity (10.96 S cm−1) among MOFs for single crystal measurements. This approach provides an ideal roadmap for producing highly conductive MOFs with great potential for applications in batteries, thermoelectric, supercapacitors and related areas.

Cysteine (Cys) and homocysteine (Hcy) are two of important biological thiols and function as important roles in several biological processes. The development of Cys and Hcy probes will help to explore the functions of biothiols in biological systems. In this work, a new coumarin-based probe AC, containing an acryloyl moiety, was developed for Cys and Hcy detection in cells. Cys and Hcy undergo a nucleophilic addition and subsequent cyclization reaction to remove to the acryloyl group and yield a fluorescent product, 7-hydroxylcomuarin. The probe AC showed good selectivity for cysteine and homocysteine over glutathione and other amino acids and had low detection limits of 65nM for Cys and 79nM for Hcy, respectively. Additionally, confocal imaging experiments demonstrated that the probe AC can be applied to visualize Cys and Hcy in living cells.

Objectives The publication of anesthesiology papers presents the importance of understanding the corresponding research activity. This research used the bibliographic method to investigate the publication trend in anesthesiology using Science Citation Index Expanded over the period 1995–2014. Methods The journals listed in the subject category of anesthesiology in the 2014 Journal Citation Reports were selected, and bibliographic information was collected from Science Citation Index Expanded, with 128,003 papers published from 1995 to 2014. Only the document type "article" was analyzed. The productivity and impact of various journals, countries, and institutions are discussed. Results A total of 64,199 articles published from 1995 to 2014, with 1,084,491 cited times, were examined. The total number of articles published by journals showed a slight increase in the 2 nd decade. More than 45% of these articles were published by the top five journals, which have maintained their ranking over 2 decades. Most publications originated from North America and European countries, of which the United States had the highest number of publications and citations. Most of the institutions are academic universities and hospitals. More than half of the top 25 institutions (in rankings) are located in the United States, and Harvard University accounted the highest number of articles and citations among all institutions. Conclusion The results reported here may aid clinicians and researchers to better understand the worldwide contribution of anesthesiology research activities over 2 decades.

The development of fluorescent probes to detect trace metal ions in biological samples has been in great need. Herein, a fluorescence turn-on sensor (PHC) was designed for highly selective detection of Cu2+ ions. The probe PHC shows weak fluorescence due to imine isomerization. With Cu2+, a significant blue emission due to Cu2+-induced oxidation of imine to a carboxylate group is observed. The turn-on process is observed with a 63-fold increase of fluorescence quantum yield (from 0.004 to 0.252). The emission intensity has a good linear relation at Cu2+ concentrations of 0–40 μM. The detection limit is estimated as 8 nM (S/N = 3). The maximum emission change induced by Cu2+ is found in the pH range of 6.5–8.0. The probe PHC can be applied in detecting Cu2+ in living cells monitored by confocal fluorescence microscopy imaging.

A new coumarin-based fluorescent probe CAA containing an acrylamide group has been designed and synthesized for the detection of biothiols. The probe CAA shows high selectivity and sensitivity for cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) over other amino acids. A fluorescence turn-on response is induced by a Michael-type reaction. It shows a highly sensitive fluorescence emission to Cys, Hcy, and GSH, with detection limits of 192 nM for Cys, 158 nM for Hcy, and 155 nM for GSH (S/N = 3). Furthermore, confocal fluorescence microscopy imaging using RAW264.7 macrophages demonstrates that CAA can be an effective fluorescent probe for thiols in living cells.

This study aims to examine research collaboration between universities and industry in the field of computer science using bibliometric methods. To further understand the impact of individual countries on university–industry (UI) collaboration, data were retrieved from the computer science journal papers included in the Science Citation Index and published during the period 2002–2011. The density, degree centrality, betweenness centrality, and closeness centrality of UI collaborative networks were calculated in order to ascertain the core countries involved in international UI collaboration. This study investigates university–industry collaborative papers (UI papers) at the global and country levels. At the global level, the results show an increasing trend in UI papers and a stable UI collaboration ratio during the last decade. The average number of authors for UI papers is 4.13, which is higher than that for all other papers. Most UI papers result from two-institution collaboration, but we obser...

Designing highly conducting metal–organic frameworks (MOFs) is currently a subject of great interest for their potential applications in diverse areas encompassing energy storage and generation. Herein, a strategic design in which a metal–sulfur plane is integrated within a MOF to achieve high electrical conductivity, is successfully demonstrated. The MOF {[Cu2(6-Hmna)(6-mn)]·NH4}n (1, 6-Hmna = 6-mercaptonicotinic acid, 6-mn = 6-mercaptonicotinate), consisting of a two dimensional (–Cu–S–)n plane, is synthesized from the reaction of Cu(NO3)2, and 6,6′-dithiodinicotinic acid via the in situ cleavage of an S–S bond under hydrothermal conditions. A single crystal of the MOF is found to have a low activation energy (6 meV), small bandgap (1.34 eV) and a highest electrical conductivity (10.96 S cm−1) among MOFs for single crystal measurements. This approach provides an ideal roadmap for producing highly conductive MOFs with great potential for applications in batteries, thermoelectric, supercapacitors and related areas., Metal–organic frameworks that contain metal–sulfur chains have been demonstrated to exhibit good electrical conductivity. Here, the authors integrate a 2D metal–sulfur plane into a metal–organic framework, reporting a single crystal with a high conductivity of 10.96 S/cm.

There is no current consensus on which lumen an airway exchange catheter (AEC) should be passed through in double-lumen endotracheal tube (DLT) to exchange for a single-lumen endotracheal tube (SLT) after thoracic surgery. We report an unusual case to provide possible solution on this issue. A 71-year-old man with lung adenocarcinoma had an event of a broken exchange catheter used during a DLT replacement with a SLT, after a video-assisted thoracic surgery. The exchange catheter was impinged at the distal tracheal lumen and snapped during manipulation. All three segments of the catheter were retrieved without further airway compromises. Placement of airway tube exchanger into the tracheal lumen of double-lumen tube is a potential contributing factor of the unusual complication. We suggest an exchange catheter be inserted into the bronchial lumen in optimal depth with the adjunct of video laryngoscope, as the safe method for double-lumen tube exchange.

A coumarin-based fluorometric probe, HS1, has been successfully developed for highly sensitive and selective detection of hypochlorous acid (HOCl). The probe is based on the specific HOCl-promoted oxidation of oxime. The reaction is accompanied by a 7-fold increase in the fluorescent quantum yield (from 0.03 to 0.21). The fluorescence intensity of the reaction between HOCl and HS1 shows a good linearity in the HOCl concentration range of 1–20 μM and a low detection limit of 25 nM (S/N = 3). In addition, confocal fluorescence microscopy imaging using RAW264.7 macrophages demonstrates that the HS1 probe could be an efficient fluorescent probe for HOCl in living cells.