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Combination of nonvolatile storage and in-memory computing promises to break through the "memory bottleneck" that computing device adopts von Neumann architecture with individual computing and memory unit. Thus, the advanced nonvolatile memory device with ultrafast operation speed is urgently required. Here, the optoelectronic hybrid phase-change memory based on the Ge2Sb2Te5 material is proposed, where the picosecond laser induced reversible phase-change is utilized to write and erase the information while the resistance difference is adopted to realize the accurate information readout. Due to the significant difference in resistance between crystalline and amorphous states, a partial crystallization strategy can be adopted to achieve ultrafast SET operation. Results indicate that SET operation speed of the Ge2Sb2Te5 film and device unit can be as fast as 52 and 130 ps, respectively, while the RESET speed reaches 13 ps. In parallel, the resistance ratio of RESET to SET state is still as high as two orders of magnitude. By using partial crystallization strategy, the phase-change induced by picosecond laser only occurs from amorphous to face-centered-cubic crystalline state with low crystallinity and the defective octahedral motif is observed in the Ge2Sb2Te5 film, which is beneficial to achieve the ultrafast operation speed. At the same time, the ordered clusters existed in the as-deposited and picosecond laser induced RESET films can accelerate the nucleation process of the Ge2Sb2Te5 film, which is one of the important reasons for achieving ultrafast SET speed. The optoelectronic hybrid phase-change memory with ultrafast operation speed may be one of the promising solutions for the in-memory computing. [ABSTRACT FROM AUTHOR]

[Display omitted] • The 3D printing effect and baking quality of 3D printed bread were evaluated. • The prediction model was based on Partial least squares regression analysis. • The 3D printing properties were predicated using rheo-fermentation models. • Simultaneous acquisition of 3D printing and post-processing properties was possible. The rheological properties of dough closely correlate to a dough's ability to be three-dimensionally (3D) printed, but only weakly characterize its fermentation and baking process. This study aimed to use rheo-fermentation properties to predict rheological properties of dough, thereby obtaining indirect information on both 3D printing properties and post-processing characteristics. The 3D printing behavior and baking quality of the dough were measured. A gluten content of 13% was found to be the most suitable for 3D printing and exhibited desirable performance during fermentation and baking. Pearson correlation analysis revealed a strong correlation between rheological properties and rheo-fermentation properties. Using partial least squares regression-based models, the coefficients of determination of the prediction for rheological parameters (G′, G″, η*) were 0.920, 0.854 and 0.863, respectively, with corresponding residual prediction deviation values of 3.063, 3.774, and 4.773. These findings suggest that 3D printing of bread dough products can be easily and successfully accomplished. [ABSTRACT FROM AUTHOR]

Background: Thin endometrium negatively impacts the reproductive function. Current treatments for thin endometrium do not always improve endometrial receptivity. Preliminary evidence suggests that electroacupuncture could have potential therapy for thin endometrium in infertile women. Thus, this randomized controlled trial was designed to test whether electroacupuncture can improve endometrial receptivity in infertile women with thin endometrium.Methods: This study is a randomized, single-blinded, controlled, clinical trial. A total of 142 eligible patients will be recruited and randomly assigned to the electroacupuncture (EA) group or the sham electroacupuncture (SEA) group in a 1:1 ratio. Participants will receive 36 sessions over three menstrual cycles (12 weeks in total), with the same acupoint prescription. The primary outcome of this trial is endometrial thickness in the midluteal phase. The secondary outcomes include endometrial pattern, resistance index (RI) and pulsatility index (PI) of bilateral uterine artery and endometrium blood flow, serum estradiol (E2) and progesterone (P), and pregnancy rate. The pregnancy rate will be evaluated during a 6-month follow-up after completion of the trial. All other outcomes will be evaluated before treatment, during the treatment of 1st, 2nd, and 3rd menstrual cycle, and 6 months after treatment.Discussion: If the outcome confirms the effectiveness of electroacupuncture for thin endometrium in infertile women, this treatment will be proposed for application in clinical practice.Trial Registration: Chinese Clinical Trials Registry ChiCTR2 000029983. Registered on 18 February 2020. [ABSTRACT FROM AUTHOR]

Enantioselective β‐Alkylation In article number 2303517, Yong Huang, Jiean Chen, and co‐workers, describe a novel SN2 reaction mode for NHC‐mediated homoenolate chemistry, enabling enantioselective β‐alkylation, allylation and propargylation of enals. By combining with a “transient acyl trap” strategy, a diverse collection of chiral oxindole derivatives could be accessed, offering an efficient synthetic entry to the pyrroloindoline motif frequently encountered in natural products. [ABSTRACT FROM AUTHOR]