Search

In this study, 1-(2-bromo-4-(dimethylamino)phenyl)-4-(2-chlorobenzyl)-[1,2,4] triazolo[4,3-a]quinazolin-5(4H)-one was synthesized via a five-step reaction and its single-crystal was obtained via solution crystallization, which was followed by crystallographic analysis. The molecular structure was calculated using density functional theory (DFT) and conformational analysis showed that the optimized molecular structure from DFT was comparable with that elucidated using X-ray diffraction. At the same time, the physicochemical properties of the compound could be understood by analyzing its frontier molecular orbitals and molecular electrostatic potentials. [ABSTRACT FROM AUTHOR]

Abstract In this paper the white-light-emitting Gd 2 P 4 O 13 :Tm3+-Dy3+ phosphors were synthesized via high temperature solid-state reaction method. The X-ray diffraction of the Gd 2 P 4 O 13 :Tm3+-Dy3+ phosphors were performed. Concentration quenching of Gd 2 P 4 O 13 with Tm3+ - doped ions was studied in detail. The luminescence excitation, emission and decay measurements were performed. Energy transfer between Tm3+ and Dy3+ have been studied. The phosphor Gd 2 P 4 O 13 :Tm3+ exhibit strong blue emission ranging from 440 nm to 470 nm of Tm3+ (3H 6 → 1D 2) under 359 nm excitation. The emission peak at 456 nm is the luminescence of Tm3+ (1D 2 → 3F 4). Energy transfer process in the Dy3+-Tm3+ system is proved. This paper includes the color perception analysis of synthesized phosphors. The coordinates of Gd 2 P 4 O 13 :1%Tm3+-3%Dy3+ phosphor is very close to the white-lighting location. [ABSTRACT FROM AUTHOR]

Four new Zn II -coordination polymers (CPs), namely [Zn 3 (4-bmbpd) 2 (1,4-BDC) 3 ] ( 1 ), [Zn(4-bmbpd)(4,4′-OBA)]·H 2 O ( 2 ), [Zn 3 (4-bmbpd) 1.5 (2,2′-BDC) 3 ] ( 3 ) and [Zn(4-bmbpd)(1,3,5-HBTC)]·2H 2 O ( 4 ) (4-bmbpd = N,N′-bis(4-methylenepyridin-4-yl)-1,4-benzenedicarboxamide, 1,4-benzenedicarboxylic acid (1,4-H 2 BDC), 4,4′-oxybisbenzoic acid (4,4′-H 2 OBA), 2,2′-biphenyldicarboxylic acid (2,2′-H 2 BDC) and 1,3,5-benzenetricarboxylic acid (1,3,5-H 3 BTC)), have been synthesized with Zn II ions and the 4-bmbpd ligand in the presence of auxiliary polycarboxylate ligands under hydrothermal conditions and have been fully structurally characterized by single-crystal X-ray diffraction analyses, thermal gravimetric analyses (TG), IR spectroscopy and powder X-ray diffraction (PXRD). The structural analysis reveals that complexes 1 – 3 are all 2D networks with different structural details adjusted by the different polycarboxylate ligands. Complex 4 is a 3D threefold interpenetrated framework with an uncoordinated carboxyl group. The effect of the polycarboxylate ligands on the structures of the title complexes is discussed. The solid-state fluorescent properties of the title complexes have been determined at room temperature. The title complexes exhibited good selectivity for the luminescent detection of Fe 3+ ions in aqueous solution with mixed metal ions, which make them promising crystalline materials as luminescent probes for the Fe 3+ ion. [ABSTRACT FROM AUTHOR]

To investigate the effect of the uncoordinated groups of “V”-type dipyridylamide on the interlocking arrays of Zn(II) coordination polymers, [Zn(L 1 )(1,4-bdc)]·H 2 O ( 1 ) and [Zn(L 2 )(1,4-bdc)]·H 2 O ( 2 ) [L 1  =  N , N ′-bis(pyridin-3-yl)-5-hydroxybenzene-1,3-dicarboxamide, L 2  =  N , N ′-bis(pyridine-3-yl)-5-methylbenzene-1,3-dicarboxamide, 1,4-H 2 bdc = 1,4-benzenedicarboxylic acid] have been hydrothermally synthesized and structurally characterized by IR, TG and X-ray single-crystal diffraction. Complex 1 is a 2D 6 3 network based on [Zn(1,4-bdc)] zigzag chains and [Zn(L 1 )] 2 loops, which is further extended into 2D → 3D parallel polycatenation array. Complex 2 features a 2D (4,4) network derived from [Zn(1,4-bdc)] zigzag chains and [Zn(L 1 )] helixes, which is further extended into 2D → 3D inclined interpenetration array. The effect of the uncoordinated groups of “V”-type dipyridylamide on the structures of the title complexes was discussed. The fluorescent behaviors of 1 – 2 in aqueous solutions with Fe 3+ , Co 2+ , Ni 2+ , Cu 2+ , Zn 2+ were investigated. The photocatalytic properties of complexes 1 – 2 , Ag loaded CPs composite materials (Ag@ 1 – 2 ) and Fe 3+ -functionalized composite materials (Fe 3+ @ 1 – 2 ) for the degradation of methylene blue (MB) under ultraviolet light irradiation have been investigated. [ABSTRACT FROM AUTHOR]

Saponins from the roots of Platycodon grandiflorum, an edible medicinal plant, have shown a wide range of beneficial effects on various biological processes. In this study, an animal model was established by a single intraperitoneal injection of cisplatin (20 mg/kg) for evaluating the protective effects of saponins from the roots of P. grandiflorum (PGS, 15 mg/kg and 30 mg/kg) in mice. The results indicated that PGS treatment for 10 days restored the destroyed intestinal mucosal oxidative system, and the loosened junctions of small intestinal villi was significantly improved. In addition, a significant mitigation of apoptotic effects deteriorated by cisplatin exposure in small intestinal villi was observed by immunohischemical staining. Also, western blot showed that PGS could effectively prevent endoplasmic reticulum (ER) stress-induced apoptosis caused by cisplatin in mice by restoring the activity of PERK (an ER kinase)-eIF2 α -ATF4 signal transduction pathway. Furthermore, molecular docking results of main saponins in PGS suggested a better binding ability with target proteins. In summary, the present work revealed the underlying protective mechanisms of PGS on intestinal injury induced by cisplatin in mice. [ABSTRACT FROM AUTHOR]

Saponins from the roots of Platycodon grandiflorum, an edible medicinal plant, have shown a wide range of beneficial effects on various biological processes. In this study, an animal model was established by a single intraperitoneal injection of cisplatin (20 mg/kg) for evaluating the protective effects of saponins from the roots of P. grandiflorum (PGS, 15 mg/kg and 30 mg/kg) in mice. The results indicated that PGS treatment for 10 days restored the destroyed intestinal mucosal oxidative system, and the loosened junctions of small intestinal villi was significantly improved. In addition, a significant mitigation of apoptotic effects deteriorated by cisplatin exposure in small intestinal villi was observed by immunohischemical staining. Also, western blot showed that PGS could effectively prevent endoplasmic reticulum (ER) stress-induced apoptosis caused by cisplatin in mice by restoring the activity of PERK (an ER kinase)-eIF2 α -ATF4 signal transduction pathway. Furthermore, molecular docking results of main saponins in PGS suggested a better binding ability with target proteins. In summary, the present work revealed the underlying protective mechanisms of PGS on intestinal injury induced by cisplatin in mice. [ABSTRACT FROM AUTHOR]

Child neglect robustly predicts many behavioral problems and adulthood mental disorders, but little is known about its association with daily lifestyles and psychological development during childhood, particularly in the longitudinal study. We aimed to examine the association of child neglect with physical activity (PA), screen time (ST), eating habits (EHs), and depression/self-esteem using a two-wave follow-up study of primary schoolchildren in Wuhan, China. Data of 1085 schoolchildren aged 8–10 years (boys: 53.5%) were analyzed. Child neglect, lifestyles, and depression/self-esteem were collected in 2018 (T1) and 2019 (T2). Autoregressive cross-lagged models (ARCLMs) were fitted to explore the interrelationships among these variables. In ARCLM including child neglect and lifestyles, higher child neglect at T1 was significantly associated with higher ST and more risky EHs at T2, while insignificantly associated with PA. In ARCLM including child neglect and depression/self-esteem, lower T1 child neglect significantly predicted a higher T2 depression, but insignificantly for T2 self-esteem. In ARCLM including all variables, child neglect still significantly predicted later ST and depression, but insignificantly predicted EHs. Our study underscores that child neglect is strongly intertwined with ST, EHs, and depression during childhood. The prevention of child neglect may promote some healthy lifestyles and depression in children. • Higher child neglect predicts later more screen time and risky eating habits among Chinese primary schoolchildren. • Higher child neglect predicts later depression among Chinese primary schoolchildren. • Depression was bi-directionally associated with self-esteem among Chinese primary schoolchildren. [ABSTRACT FROM AUTHOR]

MicroRNA‐142‐3p (miR‐142‐3p) was previously investigated in various cancers, whereas, it's role in breast cancer (BC) remains far from understood. In this study, we found that miR‐142‐3p was markedly decreased both in cell lines and BC tumor tissues. Elevated miR‐142‐3p expression suppressed growth and metastasis of BC cell lines via gain‐of‐function assay in vitro and in vivo. Mechanistically, miR‐142‐3p could regulate the ras‐related C3 botulinum toxin substrate 1 (RAC1) expression in protein level, which simultaneously suppressed the epithelial‐to‐mesenchymal transition related protein levels and the activity of PAK1 phosphorylation, respectively. In addition, rescue experiments revealed RAC1 overexpression could reverse tumor‐suppressive role of miR‐142‐3p. Our results showed miR‐142‐3p could function as a tumor suppressor via targeting RAC1/PAK1 pathway in BC, suggesting a potent therapeutic target for BC treatment. [ABSTRACT FROM AUTHOR]

Abstract Due to dramatic growth of the aging population worldwide, there has been an urgent call for a public health strategy to manage healthy aging, with the ultimate goal being advancement of aging research. Considerable progress has been made in uncovering the mystery of aging process using multidisciplinary methods. There is a growing consensus in the field that aging traits which were originally thought to be disparate are likely to be interconnected. Thus, emerging research is needed to incorporate current findings of aging by building multiscale network models. This study reported the network of healthy aging research using bibliometric approaches. Based on the results, aging of the brain and muscle is a primary research focus which is a critical part of the multiscale network regulating the aging process. Among aging-associated diseases, Alzheimer's disease and frailty are among the main research focuses, and emerging work has focused on developing diagnostic tools for these diseases. For research on anti-aging interventions, calorie restriction, physical activity, and anti-aging pharmacology are the main interventions, of which the underlying mechanisms have been comprehensively studied in animal models. Highlights • A comprehensive and integrative view of current research findings on healthy aging • Brain and muscle aging is the research focus and regulating aging throughout the body • Alzheimer's disease and frailty are the intensively studied aging-associated diseases • Calorie restriction, exercise, and drugs are the majority anti-aging interventions [ABSTRACT FROM AUTHOR]

To investigate the effect of the spacers of S-/O-bridged dipyridylamides on the structures of Co(II)/Zn(II) complexes, [Co(L1)(chda)]·1.5H2O (CP1), [Co(L2)(chda)] (CP2), [Zn(L1)(hip)]·DMA·2H2O (CP3), and [Zn(L2)(hip)]·2.8H2O (CP4) [L1 = N,N′-bis(pyridine-3-yl)thiophene-2,5-dicarboxamide, H2chda = trans-1,4-cyclohexanedicarboxylic acid, L2 = N,N′-bis(pyridine-3-yl)-4,4′-oxybis(benzoic) dicarboxamide, H2hip = 5-hydroxyisophthalic acid, DMA = N,N-dimethylacetamide], have been solvothermally synthesized. X-ray single-crystal diffraction shows that CP1 is a 2-D 3,5-connected network based on Co-L1 linear chains and (Co-chda)2 double chains. CP2 features a 1-D structure derived from 1-D wave-like (Co-chda)2 double chains decorated by terminal L2 ligands. CP3 and CP4 show wave-like (4,4) networks constructed by 1-D Zn-L1 zigzag and Zn-hip zigzag (for CP3)/linear (for CP4) chains. The effect of the spacers of S-/O-bridged dipyridylamides on the structures of the title complexes was discussed. Electrochemical behaviors of CP1-CP2 and solid-state luminescent properties of CP3-CP4 were studied. The luminescence investigations show that CP3 and CP4 are recycled fluorescent probes for environmentally relevant Fe3+ ions. The photocatalytic properties for the degradation of methylene blue (MB) under ultraviolet light irradiation of CP3-CP4 and the recyclable materials after fluorescent sensing Fe3+ ions (named CP3@Fe3+ and CP4@Fe3+) have also been investigated. [ABSTRACT FROM AUTHOR]

A Co(ii) metal–organic framework (MOF) based on the pyridyl-amide-carboxylate-3-(2-pyridinecarboxylic acid)amido pyridine (HPCAP) ligand, namely [Co(PCAP)2]·2H2O (1), has been hydrothermally synthesized and structurally characterized, which was firstly used as a combined catalyst precursor to synthesize multi-walled carbon nanotubes (MWCNTs). The decomposition of ethylene in the presence of the Co-MOF by the chemical vapor deposition (CVD) method at 800 °C led to successful production of high quality as-grown MWCNT products. Interestingly, the as-grown MWCNTs exhibit high performance in the selective adsorption of Congo red (CR) with an adsorption capacity of 1639 mg g−1. [ABSTRACT FROM AUTHOR]

BACKGROUND Human exposure to cadmium (Cd) is largely attributed to consumption of vegetables grown in polluted soils. In China, guidelines set for Cd in soils are uniform for different crops and diverse soil types, but not risk based. A high-density sampling of 711 paired soil and vegetables was carried out across Guangdong, South China. We aimed to model the transfer of Cd from soil to leafy, rootstalk and fruit vegetables, and to set regional guidelines of Cd [total and diethylenetriaminepentaacetic acid ( DTPA) -extractable] in soil for vegetable safe production. RESULTS Both total and DTPA-extractable Cd concentrations in soil were good predictors for Cd in vegetables. The transfer of Cd in soil to vegetables could be estimated by nonlinear models, with better fit when using DTPA-extractable Cd than total Cd in soil. The calculated thresholds of soil total Cd were 2.42, 0.94 and 1.57 mg kg−1 whereas those of soil DTPA-extractable Cd were 1.08, 0.33 and 0.63 mg kg−1 for leafy, rootstalk and fruit vegetable fields in Guangdong, respectively, all higher than the national soil Cd threshold. CONCLUSION Cadmium-contaminated risk for vegetable production in Guangdong province might have been over-estimated according to the Chinese Environmental Quality Standard for Soil. © 2013 Society of Chemical Industry [ABSTRACT FROM AUTHOR]