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1. Benralizumab for eosinophilic granulomatosis with polyangiitis: a retrospective, multicentre, cohort study

Author

Bettiol, Alessandra, Urban, Maria Letizia, Padoan, Roberto, Groh, Matthieu, Lopalco, Giuseppe, Egan, Allyson, Cottin, Vincent, Fraticelli, Paolo, Crimi, Claudia, Del Giacco, Stefano, Losappio, Laura, Moi, Laura, Cinetto, Francesco, Caminati, Marco, Novikov, Pavel, Berti, Alvise, Cameli, Paolo, Cathébras, Pascal, Coppola, Angelo, Durel, Cécile-Audrey, Folci, Marco, Gullo, Alberto Lo, Lombardi, Carlo, Monti, Sara, Parronchi, Paola, Rivera, Carlos Martinez, Solans, Roser, Vacca, Angelo, Espígol-Frigolé, Georgina, Guarnieri, Gabriella, Bianchi, Fulvia Chieco, Marchi, Maria Rita, Tcherakian, Colas, Kahn, Jean-Emmanuel, Iannone, Florenzo, Venerito, Vincenzo, Desaintjean, Charlene, Moroncini, Gianluca, Nolasco, Santi, Costanzo, Giulia Anna Maria Luigia, Schroeder, Jan Walter, Ribi, Camillo, Tesi, Michelangelo, Gelain, Elena, Mattioli, Irene, Bello, Federica, Jayne, David, Prisco, Domenico, Vaglio, Augusto, and Emmi, Giacomo

Published
2023
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2. Mollusk allergy in shrimp-allergic patients: Still a complex diagnosis. An Italian real-life cross-sectional multicenter study

Author

Scala, Enrico, Abeni, Damiano, Aruanno, Arianna, Boni, Elisa, Brusca, Ignazio, Cappiello, Francesca, Caprini, Elisabetta, Buzzulini, Francesca, Deleonardi, Gaia, Demonte, Antongiulio, Farioli, Laura, Lodi Rizzini, Fabio, Michelina Losappio, Laura, Macchia, Donatella, Manzotti, Giuseppina, Meneguzzi, Giorgia, Montagni, Marcello, Nucera, Eleonora, Onida, Rosa, Pastorello, Elide Anna, Peveri, Silvia, Radice, Anna, Rivolta, Federica, Rizzi, Angela, Giani, Mauro, Cecchi, Lorenzo, Pinter, Elena, Miglionico, Marzia, Vantaggio, Lorenzo, Pravettoni, Valerio, Villalta, Danilo, and Asero, Riccardo

Published
2022
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3. Peanut allergy in Italy: A unique Italian perspective

Author

Asero, Riccardo, Nucera, Eleonora, Rizzi, Angela, Aruanno, Arianna, Uasuf, Carina G., Manzotti, Giuseppina, Villalta, Danilo, Conte, Mariaelisabetta, Pastorello, Elide A., Losappio, Laura, Schroeder, Jan V., Pinter, Elena, Miglionico, Marzia, Vantaggio, Lorenzo, Macchia, Donatella, Radice, Anna, Marra, Alessandro M., Barzaghi, Claudio, Santucci, Annalisa, Cortellini, Gabriele, Peveri, Silvia, Montagni, Marcello, Demonte, Antongiulio, Borrelli, Paolo, Errico, Micol A., Rivolta, Federica, Pravettoni, Valerio, Sangalli, Andrea, Magnani, Monica, Celi, Giorgio, Yang, Baoran, Costantino, Maria T., Deleonardi, Gaia, Boni, Elisa, Gattoni, Marco, Rizzini, Fabio Lodi, Di Paolo, Camilla, Montera, Mariacarmela, Giordano, Annaclaudia, De Carli, Marco, Murzilli, Francesco, Fumagalli, Federica, Maffeis, Laura, Ghiglioni, Daniele Giovanni, Centonze, Simone, Di Lizia, Michela, Calafiore, Paolo, and Scala, Enrico

Published
2022
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4. Ophthalmic vascular manifestations in eosinophil-associated diseases: a comprehensive analysis of 57 patients from the CEREO and EESG networks and a literature review

Author

Chapuis, Elisa, primary, Bousquet, Elodie, additional, Viallard, Jean-François, additional, Terrier, Benjamin, additional, Amoura, Zahir, additional, Batani, Veronica, additional, Brézin, Antoine, additional, Cacoub, Patrice, additional, Caminati, Marco, additional, Chazal, Thibaud, additional, Comarmond, Cloé, additional, Durieu, Isabelle, additional, Ebbo, Mikael, additional, Grall, Maximilien, additional, Ledoult, Emmanuel, additional, Losappio, Laura, additional, Mattioli, Irene, additional, Mékinian, Arsène, additional, Padoan, Roberto, additional, Regola, Francesca, additional, Schroeder, Jan, additional, Seluk, Lior, additional, Trefond, Ludovic, additional, Wechsler, Michael E., additional, Lefevre, Guillaume, additional, Kahn, Jean-Emmanuel, additional, Sève, Pascal, additional, and Groh, Matthieu, additional

Published
2024
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6. Mollusk allergy in shrimp-allergic patients: still a complex diagnosis. An Italian multicenter study

Author

Scala, Enrico, primary, A, Aruanno, additional, Elisa, Boni, additional, Brusca, Ignazio, additional, Francesca, Cappiello, additional, Elisabetta, Caprini, additional, Buzzulini, Francesca, additional, Deleonardi, Gaia, additional, A, Demonte, additional, Farioli, Laura, additional, Lodi-Rizzini, Fabio, additional, Losappio, Laura, additional, Macchia, Donatella, additional, Manzotti, Giuseppina, additional, Giorgia, Meneguzzi, additional, Marcello, Montagni, additional, Nucera, Eleonora, additional, Rosa, Onida, additional, Pastorello, Elide Anna, additional, peveri, silvia, additional, Radice, Anna, additional, Rivolta, Federica, additional, Rizzi, Angela, additional, Giani, Mauro, additional, Cecchi, Lorenzo, additional, E, Pinter, additional, Marzia, Miglionico, additional, L, Vantaggio, additional, V, Pravettoni, additional, Villalta, Danilo, additional, and Asero, Riccardo, additional

Published
2024
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7. The Severity and Frequency of Systemic Reactions to Hazelnut Are Significantly Higher in Hazelnut Allergic Patients Monosensitized to Cor a 8 than in Patients Polysensitized to Cor a 1, Cor a 8, and Cor a 9

Author

Pastorello, Elide Anna, primary, Scibilia, Joseph, additional, Rossi, Carlo Maria, additional, Toscano, Alessandro, additional, Losappio, Laura Michelina, additional, Nichelatti, Michele, additional, Aversano, Maria Gloria, additional, and Farioli, Laura, additional

Published
2023
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8. Anxiety and Depression Effects During Drug Provocation Test

Author

Losappio, Laura Michelina, Cappai, Alessandra, Arcolaci, Alessandra, Badiu, Iuliana, Bonadonna, Patrizia, Boni, Elisa, Bussolino, Claudia, Caminati, Marco, Galati, Pietro, Heffler, Enrico, Intravaia, Rossella, Mauro, Marina, Massaro, Ilaria, Romano, Antonino, Rumi, Gabriele, Parolo, Anna, Pizzimenti, Stefano, Nichelatti, Michele, and Pastorello, Elide Anna

Published
2018
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9. The Severity and Frequency of Systemic Reactions to Hazelnut Are Significantly Higher in Hazelnut Allergic Patients Monosensitized to Cor a 8 than in Patients Polysensitized to Cor a 1, Cor a 8, and Cor a 9.

Author

Pastorello, Elide Anna, Scibilia, Joseph, Rossi, Carlo Maria, Toscano, Alessandro, Losappio, Laura Michelina, Nichelatti, Michele, Aversano, Maria Gloria, and Farioli, Laura

Subjects
URTICARIA, HAZELNUTS, FOOD allergy, LIPID transfer protein
Abstract

Introduction: Hazelnuts are a leading trigger of food allergy. To date, several molecular components of hazelnut are available for component-resolved diagnosis. However, little is known about how simultaneous sensitization to multiple allergens affects the severity of the hazelnut-induced reaction. In a previous study, our group demonstrated a lower risk of systemic reactions to peach in patients sensitized to both Pru p 3 and Pru p 1 than in the patient monosensitized to peach LTP. We aimed to assess whether this was also true in hazelnut allergy in a cohort of adult patients. Methods: Patients were selected based on a history of symptoms such as urticaria, vomiting, diarrhea, asthma, and anaphylaxis indicative of hazelnut IgE-mediated food allergy and graded according to a clinical severity scale. For all patients, specific IgE was determined for Cor a 1 and Cor a 8 and, for most patients, also Cor a 9. Patients were offered an oral food challenge in open format (OFC) with a cocoa-based roasted hazelnut spread on a voluntary basis in order to prescribe an appropriate diet. Results: A total of two hundred and fourteen patients were recruited. Among these, 43 patients were monosensitized to Cor a 8. One hundred and seventy-one patients were sensitized to Cor a 1 (79.9%), and, among them, 48/171 (28.1%) were also Cor a 8 positive. Cor a 9 was evaluated in 124/214 patients, testing positive in 21/124 (16.9%). Patients monosensitized to Cor a 8 experienced systemic reactions more frequently than those sensitized to Cor a 1 ± Cor a 8 (p < 0.00001), with significantly more severe reactions (p < 0.0005) and testing more frequently positive at OFC (p < 0.0001). Regarding Cor a 9, the sensitized patients were significantly younger (p = 0.0013) and showed reactions of similar severity to patients who tested Cor a 9 negative, and these reactions were milder than in patients monosensitized only to Cor a 8. Discussion/Conclusion: Sensitization to Cor a 1 seems to protect from the development of the severe systemic reactions induced by Cor a 8 sensitization, Cor a 9 does not influence the severity of symptoms in adult patients. The OFC with roasted hazelnut may help in dietary guidance. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Preliminary pilot study results of the EAACI allergy educational needs in primary care pediatricians Task Force in managing allergic disorders

Author

Cabrera, Martha, primary, Ryan, Dermot, additional, Erlewyn‐Lajeunesse, Michel, additional, Levin, Michael Eliad, additional, Martínez‐Cañavate, Ana, additional, Villaizán Pérez, Carmen, additional, Angier, Elizabeth, additional, Trujillo, Juan, additional, Cárdenas‐Rebollo, José Miguel, additional, Losappio, Laura, additional, and Reali, Laura, additional

Published
2023
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13. Pest sensitization to cockroach, mouse, and rat: An Italian multicenter study

Author

Liccardi, Gennaro, primary, Bilò, Maria Beatrice, additional, Calzetta, Luigino, additional, Milanese, Manlio, additional, Martini, Matteo, additional, Bresciani, Megon, additional, Cilia, Marcello, additional, Cucinelli, Francesco, additional, D'Angelo, Romina, additional, Feliziani, Annamaria, additional, Filon, Francesca Larese, additional, Longo, Rocco, additional, Losappio, Laura, additional, Manzotti, Giusy, additional, Minale, Paola, additional, Modica, Stella, additional, Murzilli, Francesco, additional, Musarra, Antonino, additional, Pingitore, Giuseppe, additional, Polillo, Battista Roberto, additional, Puggioni, Francesca, additional, Quercia, Oliviero, additional, Rapone, Carla, additional, and Rogliani, Paola, additional

Published
2022
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17. Pest sensitization to cockroach, mouse, and rat: An Italian multicenter study.

Author

Liccardi, Gennaro, Bilò, Maria Beatrice, Calzetta, Luigino, Milanese, Manlio, Martini, Matteo, Bresciani, Megon, Cilia, Marcello, Cucinelli, Francesco, D'Angelo, Romina, Feliziani, Annamaria, Filon, Francesca Larese, Longo, Rocco, Losappio, Laura, Manzotti, Giusy, Minale, Paola, Modica, Stella, Murzilli, Francesco, Musarra, Antonino, Pingitore, Giuseppe, and Polillo, Battista Roberto

Subjects
COCKROACHES, PESTS, MICE, ALLERGENIC extracts, RATS, CAT diseases
Published
2023
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18. Current allergy educational needs in primary care. Results of the EAACI working group on primary care survey exploring the confidence to manage and the opportunity to refer patients with allergy

Author

Cabrera, Martha, primary, Ryan, Dermot, additional, Angier, Elisabeth, additional, Losappio, Laura, additional, Flokstra ‐ de Blok, Bertine M. J., additional, Gawlik, Radoslaw, additional, Purushotam, Dan, additional, and Bosnic‐Anticevich, Sinthia, additional

Published
2021
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20. Basal Tryptase High Levels Associated with a History of Arterial Hypertension and Hypercholesterolemia Represent Risk Factors for Severe Anaphylaxis in Hymenoptera Venom-Allergic Subjects over 50 Years Old

Author

Pastorello, Elide Anna, primary, Borgonovo, Linda, additional, Preziosi, Donatella, additional, Schroeder, Jan Walter, additional, Pravettoni, Valerio, additional, Aversano, Maria Gloria, additional, Pastori, Stefano, additional, Bilò, Maria Beatrice, additional, Piantanida, Marta, additional, Losappio, Laura Michelina, additional, Nichelatti, Michele, additional, Rossi, Carlo Maria, additional, and Farioli, Laura, additional

Published
2020
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22. Current allergy educational needs in primary care. Results of the EAACI working group on primary care survey exploring the confidence to manage and the opportunity to refer patients with allergy.

Author

Cabrera, Martha, Ryan, Dermot, Angier, Elisabeth, Losappio, Laura, Flokstra ‐ de Blok, Bertine M. J., Gawlik, Radoslaw, Purushotam, Dan, and Bosnic‐Anticevich, Sinthia

Subjects
PRIMARY care, ALLERGIES, CONFIDENCE, THERAPEUTICS, LIKERT scale
Abstract

The aim of this survey was to explore the specific educational needs of a cohort of European GPs with regards to allergy training so that future educational initiatives may better support the delivery of allergy services in primary care. Method: This study took the form of a cross‐sectional observational study in which a structured electronic questionnaire was distributed to primary care providers, in eight languages, across 8 European countries between September 2019 and November 2019. Data associated with demographic parameters, professional qualifications, type of employment, level of confidence regarding competencies for diagnosis and treatment of allergic diseases, referral of patients to allergist and preferred method of learning and assessment were collected. A 5‐point Likert scale was used to assess level of confidence. Exploratory analysis was carried out. Results: A total of 687 responses were available for analysis, with 99.3% of responders working within Europe. 70.1% of participants were female; and 48.0% and 48.0% of participants respectively had received some undergraduate and/or postgraduate allergy education. Confidence in dealing with different aspect of allergy management differed between countries. The main reason for specialist referral was a perceived need for tertiary assessment (54.3%), and the main barrier for referral was the consideration that the patient's condition could be appropriately diagnosed and treated in a primary care facility. Up to 44.7% and 55.3% of participants reported that they preferred e‐Learning over traditional learning. Conclusions: This study identified the specific areas of skills training and educational needs of GPs in managing allergic conditions in primary care, and provided insights into possible strategies for more feasible and cost‐effective approaches. [ABSTRACT FROM AUTHOR]

Published
2022
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23. Favorable Prognosis of Wheat Allergy in Adults

Author

Valerio Pravettoni, Corrado Mirone, M Rossi Carlo, Laura Farioli, Elide A. Pastorello, M Losappio Laura, and Joseph Scibilia

Subjects
Adult, Male, Allergy, medicine.medical_specialty, Adolescent, Immunology, Wheat Hypersensitivity, Cross Reactions, 01 natural sciences, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Quality of life, Food allergy, Internal medicine, medicine, Immunology and Allergy, Ingestion, Humans, Triticum, Skin Tests, business.industry, 010401 analytical chemistry, food and beverages, Allergens, Immunoglobulin E, Middle Aged, medicine.disease, Prognosis, 0104 chemical sciences, Natural history, Patient Outcome Assessment, 030228 respiratory system, Cohort, Female, business, Anaphylaxis, Wheat allergy, Follow-Up Studies
Abstract

Background and objective Wheat ingestion can lead to disorders such as IgE-mediated food allergy and wheat-dependent exercise-induced anaphylaxis (WDEIA), both of which are associated with impaired quality of life and significant morbidity. Allergy to wheat is relatively benign in children, although its natural history in adults is still unknown. Objective: We used placebo-controlled challenge to evaluate the natural history of wheat hypersensitivity in atopic patients with adultonset wheat allergy. Methods We enrolled 13 patients from an initial cohort of adult patients with IgE-mediated wheat allergy (mean age, 40 years). After diagnosis, the patients observed a wheat-free diet and were followed as outpatients for 5 years to evaluate wheat exposure. Wheat-IgEtiters were determined at the end of follow-up, and a second wheat-challenge was performed. Results Ten out of 13 patients took part in the study. The mean period of wheat avoidance was 4.2 years. Three patients had spontaneously reintroduced wheat before the second evaluation, after a mean (IQR) of 28 (18-36) months, with only mild gastrointestinal discomfort at reintroduction. At the end of follow-up, 9 of the 10 patients were wheat-tolerant. Two patients had a history of WDEIA. We observed a reduction in IgE levels, with median (IQR) IgE falling from 2.77 (0.35-100) kU/L at diagnosis to 0.88 (0.1-20.8) kU/L. The association between IgE and a negative challenge result was not statistically significant. Conclusion IgE-mediated wheat allergy in adults is benign and represents a temporary break in gastrointestinal tolerance. Future studies may improve our knowledge of wheat allergens, routes of and factors leading to sensitization, and prognostic biomarkers.

Published
2019

24. Additional file 1: of 'Characteristics of patients admitted to emergency department for asthma attack: a real-LIFE study'

Author

Losappio, Laura, Heffler, Enrico, Carpentiere, Rossella, Fornero, Monica, Cannito, Cosimo, Guerrera, Francesco, Puggioni, Francesca, Monti, Riccardo, Nicola, Stefania, Rolla, Giovanni, and Brussino, Luisa

Subjects
immune system diseases, humanities, respiratory tract diseases
Abstract

“Asthma questionnaire – Emergency Department admission due to asthma attack” Description of data: the questionnaire contains data assessing asthma diagnosis and management, primary vital signs and drugs administered in Emergency Department (ED) in patients admitted to the ED for an acute asthma attack. (DOCX 15 kb)

Published
2019
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25. Anti-Neutrophil Cytoplasmic Antibodies Positivity and Anti-Leukotrienes in Eosinophilic Granulomatosis with Polyangiitis: A Retrospective Monocentric Study on 134 Italian Patients

Author

Schroeder, J, Folci, M, Losappio, L, Chevallard, M, Sinico, R, Mirone, C, De Luca, F, Nichelatti, M, Pastorello, E, Schroeder, Jan Walter, Folci, Marco, Losappio, Laura Michelina, Chevallard, Michel, Sinico, Renato Alberto, Mirone, Corrado, De Luca, Fabrizio, Nichelatti, Michele, Pastorello, Elide Anna, Schroeder, J, Folci, M, Losappio, L, Chevallard, M, Sinico, R, Mirone, C, De Luca, F, Nichelatti, M, Pastorello, E, Schroeder, Jan Walter, Folci, Marco, Losappio, Laura Michelina, Chevallard, Michel, Sinico, Renato Alberto, Mirone, Corrado, De Luca, Fabrizio, Nichelatti, Michele, and Pastorello, Elide Anna

Abstract

Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic vasculitis associated with asthma, anti-neutrophil cytoplasmic antibodies (ANCA) positivity, and tissue eosinophilia. Objective: To describe the presenting clinical features, significant biochemical alterations, and also potential pathogenic factors in adult patients diagnosed in our Center over a period of >20 years. Method: A retrospective study of EGPA patients diagnosed from 1994 to 2019 at ASST Grande Ospedale Metropolitano Niguarda Ca' Granda, Milan (Italy), which was performed according to the 1990 American College of Rheumatology criteria and Chapel Hill Consensus Conference definition. A dataset was compiled, registering demographic and clinical features, biochemical analysis at onset, and also the therapies received 3 months prior to EGPA diagnose. Statistical analyses were subsequently conducted dividing patients in 2 groups based on ANCA positivity and comparing them. Results: Two groups were clearly identified by ANCA serology and specific organ involvement in accordance with literature reports; however, our data underline for the first time the association between anti-leukotriene receptor antagonists (LTRAs) and ANCA positivity. The group of previously treated patients presents an OR of 6.42 to be ANCA positive. This finding could be attributed to an imbalanced stimulation of leukotriene receptors, inducing both mast cells activation and an increased neutrophil extracellular traps release from neutrophils. Conclusion: Despite the limitations of this retrospective study, the association between LTRAs and ANCA antibodies elucidates the mechanism by which innate immunity is directly involved in tolerance breakdown and autoantibodies production. Validation of our results with targeted studies could clarify the differences between ANCA-positive and ANCA-negative patients with important consequences on the use of some drug classes in the treatment of EGPA and asthmatic subjects.

Published
2019

26. House dust mite allergy in Italy. Diagnostic and clinical relevance of Der p 23 (and of minor allergens): A real life, multicenter study

Author

Celi, Giorgio, Brusca, Ignazio, Scala, Enrico, Villalta, Danilo, Pastorello, Elide, Farioli, Laura, Cortellini, Gabriele, Deleonardi, Gaia, Galati, Pietro, Losappio, Laura, Manzotti, Giuseppina, Pirovano, Barbara, Muratore, Lionello, Murzilli, Francesco, Cucinelli, Francesco, Musarra, Antonino, Cilia, Marcello, Nucera, Eleonora, Aruanno, Arianna, Ria, Francesco, Patria, Maria Francesca, Varin, Elena, Polillo, Battista Roberto, Sargentini, Vittorio, Quercia, Oliviero, Uasuf, Carina Gabriela, Zampogna, Stefania, Carollo, Michela, Graci, Stefania, Amato, Stefano, Mistrello, Gianni, Asero, Riccardo, Nucera, Eleonora (ORCID:0000-0002-0565-7680), Ria, Francesco (ORCID:0000-0002-8444-0307), Celi, Giorgio, Brusca, Ignazio, Scala, Enrico, Villalta, Danilo, Pastorello, Elide, Farioli, Laura, Cortellini, Gabriele, Deleonardi, Gaia, Galati, Pietro, Losappio, Laura, Manzotti, Giuseppina, Pirovano, Barbara, Muratore, Lionello, Murzilli, Francesco, Cucinelli, Francesco, Musarra, Antonino, Cilia, Marcello, Nucera, Eleonora, Aruanno, Arianna, Ria, Francesco, Patria, Maria Francesca, Varin, Elena, Polillo, Battista Roberto, Sargentini, Vittorio, Quercia, Oliviero, Uasuf, Carina Gabriela, Zampogna, Stefania, Carollo, Michela, Graci, Stefania, Amato, Stefano, Mistrello, Gianni, Asero, Riccardo, Nucera, Eleonora (ORCID:0000-0002-0565-7680), and Ria, Francesco (ORCID:0000-0002-8444-0307)

Abstract

House dust mites (HDM) area major cause of respiratory allergy and of perennial asthmaworldwide. 32 allergens for Dermatophagoidesfarinae(D2) and 21 for Dermatophagoides pteronyssinus(D1) have been detectedso farand novel allergens are still being reported(1). Der p 23, a gut-derived peritrophin present in the outer membrane of mite feces (2),has been recognized as a major allergen (2,3).Der p 1, Der p 2, Der p 23, and Der p 10(tropomyosin)are theonly allergens currently available for the component-resolved diagnosis of HDMallergyon ImmunoCAP.The clinical relevance of Der p 23 is only partially defined, and the prevalence and relevance of the exclusive sensitization to allergensother than groups1, 2, 10, and 23 has received little attention so far. We addressed these aspects ina large multicenter study.

Published
2019

28. House dust mite allergy in Italy—Diagnostic and clinical relevance of Der p 23 (and of minor allergens): A real‐life, multicenter study

Author

Celi, Giorgio, primary, Brusca, Ignazio, additional, Scala, Enrico, additional, Villalta, Danilo, additional, Pastorello, Elide, additional, Farioli, Laura, additional, Cortellini, Gabriele, additional, Deleonardi, Gaia, additional, Galati, Pietro, additional, Losappio, Laura, additional, Manzotti, Giuseppina, additional, Pirovano, Barbara, additional, Muratore, Lionello, additional, Murzilli, Francesco, additional, Cucinelli, Francesco, additional, Musarra, Antonino, additional, Cilia, Marcello, additional, Nucera, Eleonora, additional, Aruanno, Arianna, additional, Ria, Francesco, additional, Patria, Maria Francesca, additional, Varin, Elena, additional, Polillo, Battista Roberto, additional, Sargentini, Vittorio, additional, Quercia, Oliviero, additional, Gabriela Uasuf, Carina, additional, Zampogna, Stefania, additional, Carollo, Michela, additional, Graci, Stefania, additional, Amato, Stefano, additional, Mistrello, Gianni, additional, and Asero, Riccardo, additional

Published
2019
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29. Anti-Neutrophil Cytoplasmic Antibodies Positivity and Anti-Leukotrienes in Eosinophilic Granulomatosis with Polyangiitis: A Retrospective Monocentric Study on 134 Italian Patients

Author

Schroeder, Jan Walter, primary, Folci, Marco, additional, Losappio, Laura Michelina, additional, Chevallard, Michel, additional, Sinico, Renato Alberto, additional, Mirone, Corrado, additional, De Luca, Fabrizio, additional, Nichelatti, Michele, additional, and Pastorello, Elide Anna, additional

Published
2019
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30. Basal Tryptase High Levels Associated with a History of Arterial Hypertension and Hypercholesterolemia Represent Risk Factors for Severe Anaphylaxis in Hymenoptera Venom-Allergic Subjects over 50 Years Old.

Author

Pastorello, Elide Anna, Borgonovo, Linda, Preziosi, Donatella, Schroeder, Jan Walter, Pravettoni, Valerio, Aversano, Maria Gloria, Pastori, Stefano, Bilò, Maria Beatrice, Piantanida, Marta, Losappio, Laura Michelina, Nichelatti, Michele, Rossi, Carlo Maria, and Farioli, Laura

Subjects
TRYPTASE, HYPERCHOLESTEREMIA, HYMENOPTERA, ANAPHYLAXIS, GENDER, ATOPY, VENOM hypersensitivity
Abstract

Introduction: Allergy to Hymenoptera venom (HV) may lead to life-threatening anaphylaxis. Some of the factors influencing the symptom's severity are still undetermined. The aim of this study was to identify the clinical aspects associated with the most severe reactions in a population with HV allergy, by comparing clinical and immunochemical biomarkers between patients with previous local large reactions (LLRs) and systemic reactions (SRs). Methods: We selected adult patients with a history of HV allergy, with positive diagnostic tests and a correlation with one single Hymenoptera species. Age, gender, atopy, serum basal tryptase (sBT) value, total IgE, venom-specific IgE, history of hypertension, cardiovascular diseases, and hypercholesterolemia were compared between patients with previous LLRs and SRs. Results: 460 adult patients (381 SRs, 79 LLRs) were included. Age (p = 0.0097), male gender (p < 0.0001), arterial hypertension (p = 0.046), hypercholesterolemia (p = 0.009), and higher sBT levels (p = 0.0004) were significantly associated with severe reactions as independent variables. Moreover, considering the previous variables as risk factors, there was a significant and progressive increase in the odds of being Mueller III + IV as the number of positive variables increased. Patients with sBT ≥6.4 ng/mL adjusted for any of the positive variables had increased the risk of Mueller grade IV reaction (p < 0.0001). Conclusion: According to our results, older age, male gender, arterial hypertension, hypercholesterolemia, and increased levels of sBT ≥6.4 ng/mL are risk factors for severe anaphylaxis to HV in adults. Atopy and allergic asthma do not increase the risk of HV-induced SRs. [ABSTRACT FROM AUTHOR]

Published
2021
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31. A survey of clinical features of allergic rhinitis in adults

Author

Frati, Franco, Dell’Albani, Ilaria, Passalacqua, Giovanni, Bonini, Sergio, Rossi, Oliviero, Senna, Gianenrico, Incorvaia, Cristoforo, Albano, Monica, Allegretti, Lucrezia, Altomonte, Giorgia, Antico, Andrea, Arena, ANTONIO IGNAZIO, Ariano, Renato, Arigliano, Pasquale, Arrigoni, Paola, Arsieni, Augusto, Aruanno, Arianna, Bernardis, Paola, Berra, Adriano, Billeri, Lucia, Boccafogli, Arrigo, Borghesan, Franco, Borgonovo, Linda, Borrelli, Paolo, Braga, Marina, Bresciani, Megan, Bruno, Guglielmo, Bruno, Massimo, Bruzzese, Domenico, Buonomo, Alessandro, Cadario, Gianni, Candi, Paolo, Cantone, Renato, Capretti, Stefania, Carabelli, Anna, Caramazza, Rino, Carbonara, Annamaria, Carosso, Aurelia, Caruso, Cristiano, Caruso, Riccardo, Casino, Giuseppe, Casotto, Stefano, Castellano, Francesco, Castiglioni, Gloria, Cecchi, Lidia, Chiarini, Francesca, Bianchi, Fulvia Chieco, Cinquepalmi, Giuseppe, Cinquini, Massimo, Cocchi, Silvia, Colangelo, Caterina, Colombo, Giselda, Cortellini, Gabriele, Crescioli, Stefano, Crimi, Nunzio, Cucinelli, Francesco, Curcio, Antonio, Cutajar, Marina, D’Amato, Gennaro, De Palma, Rafaele, Del Pozzo, Giuseppe, Torre, Fabrizio Della, Donne, Pantalea Delle, Di Claudio, Fabio, Di Leo, Elisabetta, Di Lorenzo, Gabriele, Di Marco, Giuseppe, Di Rocco Cesinaro, Paola, Distaso, Maria, Ditta, Vito, Emiliani, Francesca, Ermini, Giuseppe, Facchetti, Susanna, Farsi, Alessandro, Favero, Elisabetta, Folletti, Ilenia, Franchini, Maurizio, Gammeri, Enrico, Gangemi, Sebastiano, Gani, Federica, Gargano, Domenico, Giannoccaro, Francesco, Giro, Giuseppina, Gracefa, Dario, Greco, Giacomo, Guarnieri, Gabriella, Ingrassia, Antonino, Intravaia, Rossella, Iorno, Loredana, Piana, Simona La, Rosa, Luigi La, Laddaga, Rocco, Lamanna, Carlo, Landi, Massimo, Leonetti, Luigi, Barone, Stefania Leto, Liccardi, Gennaro, Lodi Rizzini, Fabio, Losappio, Laura, Lucivero, Giacomo, Macchia, Donatella, Madonna, Francesco, Mafezzoni, Enrico, Mancuso, Vincenzo, Manetti, Roberto, Manfredi, Giacomo, Manzoni, Silvia, Marcotulli, Maria, Marengo, Fulvia, D’Ippolito, Gianna Maria, Masieri, Simonetta, Matucci, Andrea, Mauro, Marina, Melchiorre, Antonietta, Menzella, Francesco, Micucci, Corrado, Mietta, Sabrina, Milanese, Manlio, Minetti, Stefano, Modiano, Ambra, Modica, Stella, Moinaghi, Marcello, Mondino, Michela, Munno, Giorgio, Muratore, Lionello, Murzilli, Francesco, Natoli, Rosalba, Nebiolo, Franco, Nettis, Eustachio, Olivieri, Elisa, Pannofno, Alessandro, Parpanesi, Mauro, Patella, Vincenzo, Petraroli, Angelica, Peveri, Silvia, Piantanida, Marta, Pietrafesa, Maria, Pinter, Elena, Pizzimenti, Stefano, Pompilio, Luana, Porcaro, Valeria, Prandini, Paolo, Pravettoni, Valerio, Pugliese, Salvatore, Quarta, Carlo, Quecchia, Cristina, Quercia, Oliviero, Quilleri, Roberto, Raie, Alberto, Randazzo, Salvatore, Ridolo, Erminia, Rolla, Giovanni, Romano, Antonino, Rota, Federica, Russello, Marina, Santucci, Annalisa, Savi, Eleonora, Scarantino, Giovanna, Scarpa, Sergio, Schiavino, Domenico, Sciacca, Angelo Rito, Serra, Paolo, Severino, Maurizio, Sirena, Alberto, Spadaro, Giuseppe, Spina, Francesca, Sugamiele, Mario, Taddeo, Giordano, Ventura, Maria Teresa, Testi, Sergio, Tombetti, Enrico, Tosoni, Cinzia, Triggiani, Massimo, Tripodi, Salvatore, Vallerani, Elisabetta, Vargiu, Arnoldo, Varricchio, Attilio, Zambito, Marcello, Zanforlin, Mario, Zanoni, Giovanna, Frati, F, Dell’Albani, I, Passalacqua, G, Bonini, Sergio, Rossi, O, Senna, G, Incorvaia, C, Adult SURF Study, Group, DE PALMA, Raffaele, Frati, Franco, Dell’Albani, Ilaria, Passalacqua, Giovanni, Rossi, Oliviero, Senna, Gianenrico, Incorvaia, Cristoforo, Albano, Monica, Allegretti, Lucrezia, Altomonte, Giorgia, Antico, Andrea, Arena, Antonio, Ariano, Renato, Arigliano, Pasquale, Arrigoni, Paola, Arsieni, Augusto, Aruanno, Arianna, Bernardis, Paola, Berra, Adriano, Billeri, Lucia, Boccafogli, Arrigo, Borghesan, Franco, Borgonovo, Linda, Borrelli, Paolo, Braga, Marina, Bresciani, Megan, Bruno, Guglielmo, Bruno, Massimo, Bruzzese, Domenico, Buonomo, Alessandro, Cadario, Gianni, Candi, Paolo, Cantone, Renato, Capretti, Stefania, Carabelli, Anna, Caramazza, Rino, Carbonara, Annamaria, Carosso, Aurelia, Caruso, Cristiano, Caruso, Riccardo, Casino, Giuseppe, Casotto, Stefano, Castellano, Francesco, Castiglioni, Gloria, Cecchi, Lidia, Chiarini, Francesca, Bianchi, Fulvia Chieco, Cinquepalmi, Giuseppe, Cinquini, Massimo, Cocchi, Silvia, Colangelo, Caterina, Colombo, Giselda, Cortellini, Gabriele, Crescioli, Stefano, Crimi, Nunzio, Cucinelli, Francesco, Curcio, Antonio, Cutajar, Marina, D’Amato, Gennaro, De Palma, Rafaele, Del Pozzo, Giuseppe, Torre, Fabrizio, Donne, Pantalea Delle, Di Claudio, Fabio, Di Leo, Elisabetta, Di Lorenzo, Gabriele, Di Marco, Giuseppe, Di Rocco Cesinaro, Paola, Distaso, Maria, Ditta, Vito, Emiliani, Francesca, Ermini, Giuseppe, Facchetti, Susanna, Farsi, Alessandro, Favero, Elisabetta, Folletti, Ilenia, Franchini, Maurizio, Gammeri, Enrico, Gangemi, Sebastiano, Gani, Federica, Gargano, Domenico, Giannoccaro, Francesco, Giro, Giuseppina, Gracefa, Dario, Greco, Giacomo, Guarnieri, Gabriella, Ingrassia, Antonino, Intravaia, Rossella, Iorno, Loredana, Piana, Simona La, Rosa, Luigi La, Laddaga, Rocco, Lamanna, Carlo, Landi, Massimo, Leonetti, Luigi, Barone, Stefania Leto, Liccardi, Gennaro, Lodi-Rizzini, Fabio, Losappio, Laura, Lucivero, Giacomo, Macchia, Donatella, Madonna, Francesco, Mafezzoni, Enrico, Mancuso, Vincenzo, Manetti, Roberto, Manfredi, Giacomo, Manzoni, Silvia, Marcotulli, Maria, Marengo, Fulvia, D’Ippolito, Gianna Maria, Masieri, Simonetta, Matucci, Andrea, Mauro, Marina, Melchiorre, Antonietta, Menzella, Francesco, Micucci, Corrado, Mietta, Sabrina, Milanese, Manlio, Minetti, Stefano, Modiano, Ambra, Modica, Stella, Moinaghi, Marcello, Mondino, Michela, Munno, Giorgio, Muratore, Lionello, Murzilli, Francesco, Natoli, Rosalba, Nebiolo, Franco, Nettis, Eustachio, Olivieri, Elisa, Pannofno, Alessandro, Parpanesi, Mauro, Patella, Vincenzo, Petraroli, Angelica, Peveri, Silvia, Piantanida, Marta, Pietrafesa, Maria, Pinter, Elena, Pizzimenti, Stefano, Pompilio, Luana, Porcaro, Valeria, Prandini, Paolo, Pravettoni, Valerio, Pugliese, Salvatore, Quarta, Carlo, Quecchia, Cristina, Quercia, Oliviero, Quilleri, Roberto, Raie, Alberto, Randazzo, Salvatore, Ridolo, Erminia, Rolla, Giovanni, Romano, Antonino, Rota, Federica, Russello, Marina, Santucci, Annalisa, Savi, Eleonora, Scarantino, Giovanna, Scarpa, Sergio, Schiavino, Domenico, Sciacca, Angelo Rito, Serra, Paolo, Severino, Maurizio, Sirena, Alberto, Spadaro, Giuseppe, Spina, Francesca, Sugamiele, Mario, Taddeo, Giordano, Ventura, Maria Teresa, Testi, Sergio, Tombetti, Enrico, Tosoni, Cinzia, Triggiani, Massimo, Tripodi, Salvatore, Vallerani, Elisabetta, Vargiu, Arnoldo, Varricchio, Attilio, Zambito, Marcello, Zanforlin, Mario, and Zanoni, Giovanna

Subjects
Adult, Male, medicine.medical_specialty, Allergen immunotherapy, Sublingual, Adolescent, medicine.medical_treatment, ARIA guidelines, Desensitization, allergic rhinitis, survey data, Drug treatment, Young Adult, Patient satisfaction, Allergic, Immunologic, Allergic Rhinitis, Internal medicine, Administration, Patient compliance, Rhinitis, Seasonal, Female, Humans, Italy, Middle Aged, Patient Satisfaction, Rhinitis, Allergic, Skin Tests, Treatment Outcome, Data Collection, Medicine (all), medicine, In patient, Young adult, Rhiniti, Desensitization (medicine), High prevalence, Skin Test, Adult patients, business.industry, Settore MED/09 - MEDICINA INTERNA, General Medicine, Surgery, Public Health, business, Human
Abstract

Background: Allergic rhinitis (AR) has high prevalence and substantial socio-economic burden.Material/Methods: The study included 35 Italian Centers recruiting an overall number of 3383 adult patients with rhinitis (48% males, 52% females, mean age 29.1, range 18-45 years). For each patient, the attending physician had to fill in a standardized questionnaire, covering, in particular, some issues such as the ARIA classification of allergic rhinitis (AR), the results of skin prick test (SPT), the kind of treatment, the response to treatment, and the satisfaction with treatment.Results: Out of the 3383 patients with rhinitis, 2788 (82.4%) had AR: 311 (11.5%) had a mild intermittent, 229 (8.8%) a mild persistent, 636 (23.5%) a moderate-severe intermittent, and 1518 (56.1%) a moderate-severe persistent form. The most frequently used drugs were oral antihistamines (77.1%) and topical corticosteroids (60.8%). The response to treatment was judged as excellent in 12.2%, good in 41.3%, fair in 31.2%, poor in 14.5%, and very bad in 0.8% of subjects. The rate of treatment dissatisfaction was significantly higher in patients with moderate-to-severe AR than in patients with mild AR (p

Published
2014
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33. Mite-Induced Asthma and IgE Levels to Shrimp, Mite, Tropomyosin, Arginine Kinase, and Der p 10 Are the Most Relevant Risk Factors for Challenge-Proven Shrimp Allergy

Author

Farioli, Laura, primary, Losappio, Laura Michelina, additional, Giuffrida, Maria Gabriella, additional, Pravettoni, Valerio, additional, Micarelli, Gianluigi, additional, Nichelatti, Michele, additional, Scibilia, Joseph, additional, Mirone, Corrado, additional, Cavallarin, Laura, additional, Lamberti, Cristina, additional, Balossi, Luca Giuseppe, additional, and Pastorello, Elide Anna, additional

Published
2017
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34. A Case of Apparent Contact Dermatitis Caused by Toxocara Infection

Author

Qualizza, Rosanna, Makrì, Eleni, Losappio, Laura, and Incorvaia, Cristoforo

Subjects
Article Subject, parasitic diseases
Abstract

Infection from Toxocara species may give rise to a large array of clinical symptoms, including apparent manifestations of allergy such as asthma, urticaria/angioedema, and dermatitis. We report a case, thus far not described, of contact dermatitis attributed to nickel allergy but caused by Toxocara infection. The patient was a 53-year-old woman presenting from 10 years a dermatitis affecting head, neck, and thorax. Patch tests initially performed gave a positive result to nickel, but avoidance of contact with nickel did not result in recovery. The patient referred to our Allergy Service in 2010 because of dermatitis to feet. Patch testing confirmed the positive result for nickel, but expanding the investigation a positive result for IgG antibodies to Toxocara was detected by Western blotting and ELISA. Treatment with mebendazole achieved immediate efficacy on feet dermatitis. Then, two courses of treatment with albendazole resulted in complete regression of dermatitis accompanied by development of negative ELISA and Western blotting for Toxocara antibodies. This report adds another misleading presentation of Toxocara infection as apparent contact dermatitis caused by nickel and suggests bearing in mind, in cases of contact dermatitis not responding to avoidance of the responsible hapten and to medical treatment, the possible causative role of Toxocara.

Published
2014
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35. Mast cells and acute coronary syndromes: relationship between serum tryptase, clinical outcome and severity of coronary artery disease

Author

Morici, Nuccia, primary, Farioli, Laura, additional, Losappio, Laura Michelina, additional, Colombo, Giulia, additional, Nichelatti, Michele, additional, Preziosi, Donatella, additional, Micarelli, Gianluigi, additional, Oliva, Fabrizio, additional, Giannattasio, Cristina, additional, Klugmann, Silvio, additional, and Pastorello, Elide Anna, additional

Published
2016
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36. Identification of risk factors of severe hypersensitivity reactions in general anaesthesia

Author

Mirone, Corrado, primary, Preziosi, Donatella, additional, Mascheri, Ambra, additional, Micarelli, Gianluigi, additional, Farioli, Laura, additional, Balossi, Luca G, additional, Scibilia, Joseph, additional, Schroeder, Jan, additional, Losappio, Laura M, additional, Aversano, Maria G, additional, Stafylaraki, Chrysi, additional, Nichelatti, Michele, additional, and Pastorello, Elide A, additional

Published
2015
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39. Anti-Amoxicillin Immunoglobulin E, Histamine-2 Receptor Antagonist Therapy and Mast Cell Activation Syndrome Are Risk Factors for Amoxicillin Anaphylaxis

Author

Pastorello, Elide Anna, primary, Stafylaraki, Chrysi, additional, Mirone, Corrado, additional, Preziosi, Donatella, additional, Aversano, Maria Gloria, additional, Mascheri, Ambra, additional, Losappio, Laura Michelina, additional, Ortolani, Valeria, additional, Nichelatti, Michele, additional, and Farioli, Laura, additional

Published
2015
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42. Wheat-dependent exercise-induced anaphylaxis caused by a lipid transfer protein and not by ω-5 gliadin

Author

Pastorello, Elide Anna, primary, Farioli, Laura, additional, Stafylaraki, Chrysi, additional, Scibilia, Joseph, additional, Mirone, Corrado, additional, Pravettoni, Valerio, additional, Ottolenghi, Anna Ines, additional, Conio, Stefania, additional, Mascheri, Ambra, additional, Losappio, Laura, additional, Capocchi, Antonella, additional, Fontanini, Debora, additional, and De Giacomo, Costantino, additional

Published
2014
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43. Serum Tryptase: A New Biomarker in Patients with Acute Coronary Syndrome?

Author

Pastorello, Elide Anna, primary, Morici, Nuccia, additional, Farioli, Laura, additional, Di Biase, Matteo, additional, Losappio, Laura Michelina, additional, Nichelatti, Michele, additional, Lupica, Loredana, additional, Schroeder, Jan Walter, additional, Stafylaraki, Chrysi, additional, and Klugmann, Silvio, additional

Published
2014
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44. 5-grass pollen tablets achieve disease control in patients with seasonal allergic rhinitis unresponsive to drugs: a real-life study

Author

Pastorello,Elide Anna, Losappio,Laura, Milani,Stefania, Manzotti,Giuseppina, Fanelli,Valentina, Pravettoni,Valerio, Agostinis,Fabio, D'Arcais,Alberto Flores, Dell'Albani,Ilaria, Puccinelli,Paola, Incorvaia,Cristoforo, Frati,Franco, Pastorello,Elide Anna, Losappio,Laura, Milani,Stefania, Manzotti,Giuseppina, Fanelli,Valentina, Pravettoni,Valerio, Agostinis,Fabio, D'Arcais,Alberto Flores, Dell'Albani,Ilaria, Puccinelli,Paola, Incorvaia,Cristoforo, and Frati,Franco

Abstract

Elide Anna Pastorello,1 Laura Losappio,1 Stefania Milani,2 Giuseppina Manzotti,3 Valentina Fanelli,4 Valerio Pravettoni,5 Fabio Agostinis,6 Alberto Flores D’Arcais,7 Ilaria Dell'Albani,8 Paola Puccinelli,9 Cristoforo Incorvaia,10 Franco Frati81Allergy and Immunology Department, Niguarda Hospital, Milan, 2Allergy Department, San Marco General Hospital, Bergamo, 3Allergy Department, Treviglio Hospital, Bergamo, 4Allergy Department, Italian Institute for Auxology, Milan, 5Clinical Allergy and Immunology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, 6Department of Pediatrics, Riuniti Hospital, Bergamo, 7Department of Pediatrics, Legnano Hospital, Milan, 8Medical and Scientific Department, Stallergenes Italy, Milan, 9Regulatory Department, Stallergenes Italy, Milan, 10Allergy/Pulmonary Rehabilitation, ICP Hospital, Milan, ItalyBackground: An important subpopulation in allergic rhinitis is represented by patients with severe form of disease that is not responsive to drug treatment. It has been reported that grass pollen subcutaneous immunotherapy is effective in drug-resistant patients. In a real-life study, we evaluated the efficacy of 5-grass pollen tablets in patients with grass pollen-induced allergic rhinitis not responsive to drug therapy.Methods: We carried out this multicenter observational study in adults and adolescents with grass-induced allergic rhinitis not responsive to drug therapy who were treated for a year with 5-grass pollen tablets. Clinical data collected before and after sublingual immunotherapy (SLIT) included Allergic Rhinitis and its Impact on Asthma (ARIA) classification of allergic rhinitis, response to therapy, and patient satisfaction.Results: Forty-seven patients entered the study. By ARIA classification, three patients had moderate to severe intermittent allergic rhinitis, ten had mild persistent allergic rhinitis, and 34 had moderate to severe persistent allergic rhinitis. There were no ca

Published
2013

45. 5-grass pollen tablets achieve disease control in patients with seasonal allergic rhinitis unresponsive to drugs: a real-life study

Author

Frati, Franco, primary, Pastorello, Elide Anna, additional, Losappio, Laura, additional, Milani, Stefania, additional, Manzotti, Giuseppina, additional, Fanelli, Valentina, additional, Pravettoni, Valerio, additional, Agostinis, Fabio, additional, D'Arcais, Alberto Flores, additional, Dell'Albani, Ilaria, additional, Puccinelli, Paola, additional, and Incorvaia, Cristoforo, additional

Published
2013
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46. Rice Allergy Demonstrated by Double-Blind Placebo-Controlled Food Challenge in Peach-Allergic Patients Is Related to Lipid Transfer Protein Reactivity

Author

Pastorello, Elide Anna, primary, Scibilia, Joseph, additional, Farioli, Laura, additional, Primavesi, Laura, additional, Giuffrida, Maria Gabriella, additional, Mascheri, Ambra, additional, Piantanida, Marta, additional, Mirone, Corrado, additional, Stafylaraki, Chrysi, additional, Violetta, Marta Riva, additional, Nichelatti, Michele, additional, Preziosi, Donatella, additional, Losappio, Laura, additional, and Pravettoni, Valerio, additional

Published
2013
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48. 5-grass pollen tablets achieve disease control in patients with seasonal allergic rhinitis unresponsive to drugs: a real-life study.

Author

Pastorello, Elide Anna, Losappio, Laura, Milani, Stefania, Manzotti, Giuseppina, Fanelli, Valentina, Pravettoni, Valerio, Agostinis, Fabio, D'Arcais, Alberto Flores, Dell'Albani, Ilaria, Puccinelli, Paola, Incorvaia, Cristoforo, and Frati, Franco

Subjects
PALYNOLOGY, INPATIENT care, ALLERGENS, POLLINATION, POLLEN
Abstract

Background: An important subpopulation in allergic rhinitis is represented by patients with severe form of disease that is not responsive to drug treatment. It has been reported that grass pollen subcutaneous immunotherapy is effective in drug-resistant patients. In a real-life study, we evaluated the efficacy of 5-grass pollen tablets in patients with grass pollen-induced allergic rhinitis not responsive to drug therapy. Methods: We carried out this multicenter observational study in adults and adolescents with grass-induced allergic rhinitis not responsive to drug therapy who were treated for a year with 5-grass pollen tablets. Clinical data collected before and after sublingual immunotherapy (SLIT) included Allergic Rhinitis and its Impact on Asthma (ARIA) classification of allergic rhinitis, response to therapy, and patient satisfaction. Results: Forty-seven patients entered the study. By ARIA classification, three patients had moderate to severe intermittent allergic rhinitis, ten had mild persistent allergic rhinitis, and 34 had moderate to severe persistent allergic rhinitis. There were no cases of mild intermittent allergic rhinitis before SLIT. After SLIT, 33 patients had mild intermittent allergic rhinitis, none had moderate to severe intermittent allergic rhinitis, seven had mild persistent allergic rhinitis, and seven had moderate to severe persistent allergic rhinitis. The mean medication score decreased from 4.2±1.3 before to 2.4±2.0 after SLIT (P<0.01), representing a reduction of 42%. The response to treatment before SLIT was judged as poor by 70% of patients and very poor by 30%. Patient satisfaction was significantly increased after SLIT (P<0.01). Conclusion: In real life, most patients with grass pollen-induced allergic rhinitis not responsive to drug treatment can achieve control of the condition with one season of treatment using 5-grass pollen tablets. [ABSTRACT FROM AUTHOR]

Published
2013
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49. A case of atopic dermatitis caused by <italic>Ascaris lumbricoides</italic> infection.

Author

Qualizza, Rosanna, Losappio, Laura M, and Furci, Fabiana

Subjects
HETEROCYCLIC compounds, ANTHELMINTICS, ASCARIASIS, ATOPIC dermatitis, INTESTINAL parasites, TREATMENT effectiveness, SYMPTOMS, THERAPEUTICS
Abstract

Background: Parasite infections stimulate total and specific IgE production that, in the case of Toxocara canis infection, corresponds to chronic allergic symptoms. There may also be other infections which have similar symptoms, such as Ascaris lumbricoides infection. Ascaris lumbricoides is a large nematode that causes abdominal pain, nausea, vomiting, bloating, anorexia and intermittent diarrhoea. Patients with ascaridiasis and high IgE levels may also have allergy-like symptoms such as asthma, urticaria and atopic dermatitis. Case presentation: We report a case of atopic dermatitis caused by Ascaris lumbricoides which shows the important role of parasitic infection in patients with long-lasting dermatitis. The patient was a 12-year old female suffering since early infancy from atopic dermatitis and asthma. She was treated for dermatitis with oral bethametasone and topical pimecrolimus with little benefit. After two cycles of mebendazole therapy, the patient showed progressive improvement of symptoms. Conclusions: In patients with dermatitis, Ascaris lumbricoides infection should be not excluded: adequate anthelmintic treatment may result in complete regression from the disease. [ABSTRACT FROM AUTHOR]

Published
2018
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