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Purpose: Slow transit constipation is a common disorder in children, which often does not respond well to ordinary treatments. We have conducted a systematic review of reported studies in order to better define the current state of knowledge about electrical stimulation treatment of slow transit constipation in children. Methods: We searched PubMed, Embase, Cochrane Library, BioMed Central, and ISI Web of Knowledge with relevant terms; six studies, all from one center, met the criteria for inclusion. Two trials were randomized clinical trials, and four were prospective studies. The number of subjects included in the studies was 8 to 39, with ages 3 to 18 years. Results: Treatment sessions varied from 20 to 30 min 3 times per week to 1 h daily, and duration of therapy varied from 3 weeks to 6 months. Statistically significant improvements after electrical stimulation therapy were recorded in one to four outcome measures in each of the studies: frequency of defecation, soiling, Bristol Stool Scale, radionuclear transit studies, and quality of life; however, the improvements were of modest degree and of uncertain clinical significance. Quality assessment of the studies found various levels of bias, with attrition bias and reporting bias in all six. Conclusions: This systemic review found moderate support for the effectiveness of electrical stimulation therapy in slow transit constipation in children. However, better-designed studies, with larger and more diverse patient populations followed for longer time periods, will be needed in order to reliably determine the efficacy of electrical stimulation therapy in the treatment of this disorder. [ABSTRACT FROM AUTHOR]

This study compared proton pump inhibitors (PPIs) and histamine H2 receptor antagonists (H2RAs) for prevention of low-dose aspirin (LDA)-related gastrointestinal (GI) erosion, ulcer and bleeding. Electronic databases including PubMed, Embase, Cochrane Central Register of Controlled Trials, Chinese National Knowledge Infrastructure, Chinese Biomedical Literature Database, and WanFang Data were searched from the date of their establishment to December 31, 2013. Randomized controlled trials comparing PPIs and H2RAs for prevention of GI injury associated with low-dose aspirin (LDA) were collected. Two reviewers independently abstracted studies and patient characteristics and appraised study quality using the Cochrane risk-of-bias tool. Meta-analysis was performed using RevMan 5.1 software. We included nine RCTs involving 1047 patients. The meta-analysis showed that PPIs were superior to H2RAs for prevention of LDA-associated GI erosion/ulcer [odds ratio (OR=0.28, 95% confidence interval (CI): 0.16–0.50] and bleeding (OR=0.28, 95% CI: 0.14–0.59). In conclusion, PPIs were superior to H2RAs for prevention of LDA-related GI erosion/ulcer and bleeding. Higher quality, large, multicenter RCTs are needed to demonstrate the preventive effect of the two acid-suppressive drugs. [ABSTRACT FROM AUTHOR]

Objective To study the effect of different position on the application of capsule endoscopy through the pylorus into duodenum in gastroptosis patients. Methods Sixty gastroptosis patients who accepted OMOM capsule endoscopy from December 2007 to July 2014 were enrolled in this study. The enrolled patients were randomly divided into two groups: right lateral position group (n=30) and control group (n=30). The patients in the control group were allowed to keep upright or sitting position. The patients in the right lateral position group were instructed to lie on right side. Gastric transit time (GTT) were recorded in each patient. Results All 60 patients completed the examination and the success rate was 100% . No patients had capsule retention in the stomach. Gastric transit time in the right position group was significantly shorter than that in the control group (<0.05). Gastric transit time of moderate or severe gastroptosis patients in the right position group was significantly shorter than that of control group (<0.05). There was no significantly difference between mild gastroptosis patients of the two groups (>0.05). Conclusions The right lateral position for the gastroptosis patients can shorten gastric transit time and increase the complete examination rate of the samall bowel. For moderate or severe gastroptosis patients to shorten the transit times of CE, the right side should be taken as early as possible in order to improve the success rate of small bowel examination. [ABSTRACT FROM AUTHOR]