36 results on '"M Tia"'
Search Results
2. Factors Associated with Echocardiographic Abnormalities in Patients with Chronic Kidney Disease in a Tertiary Hospital in Ivory Coast
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Weu M. Tia, Abdoulaye Togo, Manzan A. Wognin, Reine M. Koffi, Jonathan Kpan, Bourhaima Ouattara, and Dame A. Gnionsahe
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Mechanical Engineering ,Energy Engineering and Power Technology ,Management Science and Operations Research - Published
- 2022
3. Dépistage de la maladie rénale chronique en population générale dans une ville africaine en 2022
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M. Tia, R. Koffi, J. Kpan, H. Yao, and A. Gnionsahe
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Nephrology - Published
- 2022
4. Fiber and Insulin Sensitivity
- Author
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C., Kevin, primary and M., Tia, additional
- Published
- 2011
- Full Text
- View/download PDF
5. The American Servicemembers' Protection Act: protecting whom?
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Johnson, M. Tia
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Military personnel -- Laws, regulations and rules ,Sovereignty -- Laws, regulations and rules ,Peacekeeping forces -- Laws, regulations and rules ,Government regulation ,American Servicemembers Protection Act of 2002 - Published
- 2003
6. Mobilizations and Movements of Foreign Fighters From Southeast Asia to Syria and Iraq
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Kibtiah, T. M. (Tia), Kibtiah, T. M. (Tia), Kibtiah, T. M. (Tia), and Kibtiah, T. M. (Tia)
- Abstract
This article examines foreign fighter movements, in particular those who joined the Islamic State and al-Nusra front from Southeast Asia to Syria and Iraq. It will analyze the dynamics of the movements in Southeast Asia and Syria and Iraq, provide a discussion of the potential threats of the returnees and how state and civil society respond to the threats of the groups. It is based on interviews to Afghan veterans in Indonesia and analyses of primary and secondary sources of the Syrian and Iraq conflicts. It argues that it is urgent to strengthen unity and partnership between state and civil society in coping the rise of the terrorism movements and to prevent violent attacks after the returns of Southeast Asian fighters from Syria and Iraq.
- Published
- 2016
7. Time-of-flight spectrometer for efficient coincidence detection of low-energy electrons from surfaces with 2π solid angle, pair recognition and unlimited band path (2e2πCS)
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S. Schößler, M. Tia, S. Voss, Ottmar Jagutzki, and Achim Czasch
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Physics ,Electron pair ,Radiation ,010304 chemical physics ,Spectrometer ,Synchrotron radiation ,Angle-resolved photoemission spectroscopy ,02 engineering and technology ,Electron ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Computational physics ,Time of flight ,Coincident ,Condensed Matter::Superconductivity ,Secondary emission ,0103 physical sciences ,Condensed Matter::Strongly Correlated Electrons ,Physical and Theoretical Chemistry ,0210 nano-technology ,Spectroscopy - Abstract
Time-of-flight spectrometer configurations combined with position sensitive single particle counting detectors have been simulated with a Monte Carlo code to find an efficient solution for coincident low energy electron detection. Photoemission experiments on polycrystalline silver have been performed at a synchrotron radiation facility with a likewise wide-angle ARPES (angle resolved photoemission spectroscopy) setup. Low-energy electron pairs created from secondary electron emission have been detected in coincidence obtaining their full momentum vectors.
- Published
- 2020
8. The Usefulness of 111Indium-Oxine Autologous Platelet Gel Graft Imaging to Evaluate Osteoinduction in Patients Undergoing Surgery of Jaw Bone Defects
- Author
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A. Fusco, M. Ottiero, Stefano Tetè, Gilberto Sammartino, M. Tia, L. Celentano, Elio D'Agostino, Sammartino, Gilberto, Celentano, L, Tia, M, D., Agostino E, Fusco, A, Tete, S, Ottiero, M., L., Celentano, M., Tia, D'Agostino, Elio, A., Fusco, S., Tetè, M., Ottiero, Celentano, L., Tia, M., D'Agostino, E., Fusco, A., and Tete, S.
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Adult ,Blood Platelets ,Male ,Molar ,Pathology ,medicine.medical_specialty ,Immunology ,Enucleation ,Scintigraphy ,Indium ,Bone remodeling ,PLATELET GEL ,Jaw Abnormalities ,In vivo ,Image Processing, Computer-Assisted ,medicine ,Humans ,Immunology and Allergy ,Platelet ,Cyst ,Radionuclide Imaging ,111indium-oxine ,Pharmacology ,medicine.diagnostic_test ,BONE DEFECTS ,business.industry ,Indium Radioisotopes ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Tooth Extraction ,Female ,Molar, Third ,Bone Remodeling ,Bone marrow ,Radiopharmaceuticals ,business - Abstract
Autologous platelet gel (AGP) is a source of concentrated growth factors contained in the platelet granules used to enhance bone quality and, especially, quicken bone formation in regeneration techniques, and also ameliorate the haemostasis in anti-coagulated patient management. The purpose of this study is to describe a technique to perform labelling of autologous platelet-gel with 111In -Oxine and to evaluate its usefulness, as a marker of bone osteoinduction by means of scintigraphy, after in vivo application in patients with jaw bone defects following cystic lesion enucleation and the extraction of deeply impacted lower third molar. All patients included in the study presented mandible bone defects following cyst enucleation or deeply impacted lower third molar extraction. In sterile conditions, 111In-Oxine AGP was added during the bone-milling phase of the graft preparation and then applied to the bone defects. The scintigraphy was performed 2 hours after the application of labelled AGP (early scan) and at 24, 48, 72, 384 hours (delayed scan). At early scan all the patients presented a high concentration of 111In-Oxine AGP, which was easily recognized at the level of jaw defect. Limited diffusion of AGP was seen in the tissue surrounding the bone defect; this activity was attributed to the presence, in the PRP, of a quote of autologous granulocytes, as marker of inflammatory process, which was labelled with 111In-Oxine. In order to demonstrate the persistence and stability of labelling AGP, abdominal scintigraphies were performed to assess the presence of activity in the liver, spleen and bone marrow. None of the patients presented appreciable activity in these organs. The labelled AGP topically applied showed high uptake values, without statistically significant activity in the surrounding tissues or in critical organs during the early phase, as well as in delayed controls, and confirmed a very low grade of loss of 111In-Oxine from the bone defect. The scintigraphy represents a useful method of assessing the success of surgical procedure for jaw bone defects performed with autogenous grafts. It is well accepted by the patients, offering at the same time a sensitive method of studying uptake of topically applied AGP and to follow up kinetics of AGP in order to correlate quantitative data of the platelet gel life span with evolution of the bone remodelling process. Finally, the labelled granulocytes around the bone defect allow to assess the inflammatory process evolution derived from the surgical technique.
- Published
- 2008
9. ANSWERING THE CLARION CALL TO ACTION: CONGRESS'S ROLE IN PROTECTING ELECTION SECURITY.
- Author
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JOHNSON, M. TIA
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EMAIL hacking ,VOTING ,UNITED States presidential elections ,FOREIGN electoral interference ,ELECTION boards ,ELECTIONS ,PUBLIC opinion ,VOTING registers - Published
- 2020
10. Preimplant bone regeneration: indications, possibilities and limits
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RAMAGLIA, LUCA, F. MORGESE, M. TIA, DI LAURO, ALESSANDRO ESPEDITO, SAMMARTINO, GILBERTO, Ramaglia, Luca, F., Morgese, M., Tia, DI LAURO, ALESSANDRO ESPEDITO, and Sammartino, Gilberto
- Published
- 2004
11. Growth-promoting action and growth factor release by different platelet derivatives
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Vittoria D'Esposito, Rossella Valentino, M Tia, Domenico Liguoro, Francesco Beguinot, Gilberto Sammartino, M Del Corso, M De Pascale, R Sepulveres, Pietro Formisano, Federica Passaretti, Passaretti, F, Tia, M, D'Esposito, V, Pascale, Md, Corso, Md, Sepulveres, R, Liguoro, D, Valentino, R, Beguinot, F, Formisano, P, and Sammartino, Gilberto
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Adult ,Blood Platelets ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Biology ,chemistry.chemical_compound ,Young Adult ,Platelet degranulation ,Internal medicine ,medicine ,Human Umbilical Vein Endothelial Cells ,Humans ,Platelet ,Cell Proliferation ,Platelet-Rich Plasma ,Growth factor ,Hematology ,General Medicine ,Fibroblasts ,digestive system diseases ,Vascular endothelial growth factor ,Endocrinology ,chemistry ,Platelet-rich plasma ,biology.protein ,Cytokines ,Intercellular Signaling Peptides and Proteins ,Female ,Wound healing ,Platelet-derived growth factor receptor ,Transforming growth factor - Abstract
Platelet derivatives are commonly used in wound healing and tissue regeneration. Different procedures of platelet preparation may differentially affect growth factor release and cell growth. Preparation of platelet-rich fibrin (PRF) is accompanied by release of growth factors, including platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and transforming growth factor ?1 (TGF?1), and several cytokines. When compared with the standard procedure for platelet-rich plasma (PRP), PRF released 2-fold less PDGF, but >15-fold and >2-fold VEGF and TGF?1, respectively. Also, the release of several cytokines (IL-4, IL-6, IL-8, IL-10, IFN?, MIP-1?, MIP-1? and TNF?) was significantly increased in PRF-conditioned medium (CM), compared to PRP-CM. Incubation of both human skin fibroblasts and human umbilical vein endothelial cells (HUVECs) with PRF-derived membrane (mPRF) or with PRF-CM enhanced cell proliferation by >2-fold (p < 0.05). Interestingly, PRP elicited fibroblast growth at a higher extent compared to PRF. At variance, PRF effect on HUVEC growth was significantly greater than that of PRP, consistent with a higher concentration of VEGF in the PRF-CM. Thus, the procedure of PRP preparation leads to a larger release of PDGF, as a possible result of platelet degranulation, while PRF enhances the release of proangiogenic factors.
- Published
- 2013
12. Prevalence of acquired cystic disease in black Africans on hemodialysis in West Africa
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D A, Gnionsahe, D A, Lagou, and W M, Tia
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Male ,Time Factors ,Kidney Diseases, Cystic ,Africa, Western ,Renal Dialysis ,Urinary Tract Infections ,Disease Progression ,Prevalence ,Humans ,Kidney Failure, Chronic ,Mass Screening ,Female ,Low Back Pain ,Hematuria ,Ultrasonography - Abstract
Acquired cystic kidney disease (ACKD) is a late manifestation of end-stage renal disease. To determine the prevalence of ACKD in black African patients on chronic hemodialysis in West Africa, we examined by ultrasonography the native kidneys of 83 patients from February to August 2002. ACKD was present in 26 patients, with estimated prevalence of 31% that was higher in males. There were 20 (77%) ACKD patients with a duration on dialysis of more than five years. The associated clinical manifestations were lumbar pain (58%), hematuria (23%) and urinary tract infection (23%). No case of renal cancer was detected during this study. We conclude that the prevalence of ACKD and its complications in black African patients on chronic hemodialysis in West Africa is high. We recommend that renal ultrasonography should be performed routinely in patients on hemodialysis for more than 5 years.
- Published
- 2007
13. Nutrient load analysis of Lago de Yojoa, Honduras
- Author
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Peter Shanahan., Massachusetts Institute of Technology. Dept. of Civil and Environmental Engineering., Trate, Tia M. (Tia Marie), Peter Shanahan., Massachusetts Institute of Technology. Dept. of Civil and Environmental Engineering., and Trate, Tia M. (Tia Marie)
- Abstract
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 2006., Includes bibliographical references (leaves 47-49)., Lake Yojoa, Honduras is an important natural resource to the people of Honduras. The lake's water quality has been a controversial subject. This thesis describes a nutrient load analysis performed to gain a better understanding of the water quality. Loads were calculated for point sources, non-point sources, and other sources. These loads were applied to a trophic model to determine the lake's trophic status. The results of this study seem to point out that much about tropical limnology is unknown. Lake Yojoa appears to be a mesotrophic lake with nitrogen as the limiting nutrient. However, further field evaluation of the limiting nutrient and nutrient loadings is recommended in order to provide information for better management of the lake., by Tia M. Trate., M.Eng.
- Published
- 2006
14. Prevalence of Acquired Cystic disease in Black Africans on Hemodialysis in West Africa.
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Gnionsahe, Daze A., Lagou D., A., and M., Tia W.
- Published
- 2007
15. Prevention of mandibular third molar extraction-associated periodontal defects: a comparative study
- Author
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Mariano Tia, T. Bucci, Hom-Lay Wang, Gilberto Sammartino, Sammartino, Gilberto, M., Tia, Bucci, Tommaso, and Wang, H. L.
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Adult ,Male ,Molar ,periodontology ,Gingival and periodontal pocket ,Bone Matrix ,Dentistry ,Biocompatible Materials ,Mandible ,Mandibular second molar ,Young Adult ,Postoperative Complications ,stomatognathic system ,prevention ,Periodontal Attachment Loss ,Tooth impaction ,Humans ,Periodontal Pocket ,Medicine ,Gingival Recession ,third molar ,Gingival recession ,Periodontal Diseases ,Orthodontics ,Bone mineral ,Minerals ,business.industry ,Dental Plaque Index ,Tooth, Impacted ,Membranes, Artificial ,medicine.disease ,Treatment Outcome ,Clinical attachment loss ,Bone Substitutes ,Tooth Extraction ,Guided Tissue Regeneration, Periodontal ,Periodontics ,Female ,Molar, Third ,Collagen ,Periodontal Index ,medicine.symptom ,business ,Follow-Up Studies - Abstract
Background: Extraction of deep-impacted mandibular third molars may lead to periodontal defects at the distal surface of the adjacent second molar. The purpose of this study was to compare the ability of three regenerative approaches to prevent third molar extraction-related periodontal defects. Methods: Forty-five patients with bilateral osseous or soft tissue–impacted lower third molars were selected to participate in the study. Inclusion criteria were the presence of a pocket that was located distally to the mandibular second molar with a probing depth (PD) ‡7 mm and with a probing clinical attachment level (CAL) ‡6 mm. Ninety third molar impactions were used and were randomly assigned to three equal treatment groups (30 each): bovine porous bone mineral (BPBM) alone, BPBM plus collagen membrane (CM), and an untreated control group. Clinical and radiographic measurements were recorded at 3, 6, 9, 12, 18, 24, 36, 48, 60, and 72 months after the surgery. Results: BPBM or BPBM + CM resulted in a significant reduction in PD and gain in CAL compared to the control group at all time points. BPBM + CM had the best outcome for the prevention of a second-molar periodontal defect. Conclusion: The application of BPBM, with or without a collagen membrane, can be a viable and stable treatment to alleviate the periodontal defects that are often associated with impacted mandibular third molar extractions. J Periodontol 2009;80:389-396.
- Published
- 2009
16. General practitioners' knowledge and perception of chronic kidney disease diagnosis and treatment in Lome (Togo).
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Tsevi MY, Tia M, Sabi AK, and Konan DS
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- Humans, Perception, Togo, General Practitioners, Renal Insufficiency, Chronic diagnosis, Renal Insufficiency, Chronic therapy
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- 2022
- Full Text
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17. [Renal involvement during monoclonal gammopathies at the teaching hospital of Yopougon in Abidjan, from 2000 to 2016].
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Tia Weu M, Guei Monlet C, Sawadogo A, Coulibaly Pessa A, Lagou Delphine A, and Gnionsahé Daze A
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- Cote d'Ivoire, Female, Hospitals, Teaching, Humans, Male, Middle Aged, Retrospective Studies, Time Factors, Kidney Diseases etiology, Paraproteinemias complications
- Abstract
Background: Renal involvement is common during monoclonal gammopathies and their occurrence impacts the survival of the patients. Our objective was to describe the renal features during monoclonal gammopathies from 2004 to 2016 at the University Hospital of Yopougon in Abidjan., Methods: Renal failure was defined as blood creatinine level > 20 mg/L and/or proteinuria > 500 mg/24 hours., Results: We identified 42 cases of monoclonal gammopathiesincluding multiple myeloma (n=40) and monoclonal gammopathy of underdetermined significance (n=2). The rate of renal impairment was 57% (n=24) including tubular disease (n=20)and glomerular nephropathy (n=3). Two patients (one with cast nephropathy and another with Randall's disease) performed renal biopsy. The factors associated with renal impairment were mainly hyperuricemia (n=24)and hypercalcemia (n=23). Three cases were treated by hemodialysis. There were 6 (14.3%) deaths among patients with renal impairment., Conclusion: Tubular injury was common among patients with monoclonal gammopathy. It was associated with hypercalcemia and Hyperuricemia., (Le comitée de rédaction se réserve le droit de revoyer aux auteurs avant toute soumission à l'avis des lecteurs les manuscrits qui ne seraient pas conformes à ces modalités de présentation. En outre il leur conseille de sonserver un examplaire du manuscrit, des figures et des tableaux.)
- Published
- 2018
18. An imaging photoelectron-photoion coincidence investigation of homochiral 2R,3R-butanediol clusters.
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Daly S, Powis I, Garcia GA, Tia M, and Nahon L
- Abstract
We report an experimental investigation of homochiral cluster formation in seeded molecular beam expansions of (2R,3R)-butanediol. Synchrotron radiation vacuum ultraviolet photoionization measurements have been performed using a double imaging electron-ion spectrometer in various configurations and modes of operation. These include measurements of the cluster ion mass spectra, wavelength scanned ion yields, and threshold electron spectra. Protonated cluster ions ranging up to n = 7 have been observed and size-selected photoelectron spectra and photoelectron circular dichroism (PECD) have been recorded by velocity map imaging, recorded in coincidence with ions, at a number of fixed photon energies. Translation temperatures of the cluster ions have been further examined by ion imaging measurements. As well as the sequence of protonated clusters with integral numbers of butanediol monomer units, a second series with half-integral monomer masses is observed and deduced to result from a facile cleavage of a butanediol monomer moiety within the nascent cluster. This second sequence of half-integral masses displays quite distinct behaviours. PECD measurements are used to show that the half-integral mass cluster ions do not share a common parentage with whole integer masses. Using an analogy developed with simple theoretical calculations of butanediol dimer structures, it is inferred that the dissociative branching into integral and half-integral ion mass sequences is controlled by the presence of different butanediol monomer conformations within the hydrogen bonded clusters.
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- 2017
- Full Text
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19. Observation of Enhanced Chiral Asymmetries in the Inner-Shell Photoionization of Uniaxially Oriented Methyloxirane Enantiomers.
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Tia M, Pitzer M, Kastirke G, Gatzke J, Kim HK, Trinter F, Rist J, Hartung A, Trabert D, Siebert J, Henrichs K, Becht J, Zeller S, Gassert H, Wiegandt F, Wallauer R, Kuhlins A, Schober C, Bauer T, Wechselberger N, Burzynski P, Neff J, Weller M, Metz D, Kircher M, Waitz M, Williams JB, Schmidt LPH, Müller AD, Knie A, Hans A, Ben Ltaief L, Ehresmann A, Berger R, Fukuzawa H, Ueda K, Schmidt-Böcking H, Dörner R, Jahnke T, Demekhin PV, and Schöffler M
- Abstract
Most large molecules are chiral in their structure: they exist as two enantiomers, which are mirror images of each other. Whereas the rovibronic sublevels of two enantiomers are almost identical (neglecting a minuscular effect of the weak interaction), it turns out that the photoelectric effect is sensitive to the absolute configuration of the ionized enantiomer. Indeed, photoionization of randomly oriented enantiomers by left or right circularly polarized light results in a slightly different electron flux parallel or antiparallel with respect to the photon propagation direction-an effect termed photoelectron circular dichroism (PECD). Our comprehensive study demonstrates that the origin of PECD can be found in the molecular frame electron emission pattern connecting PECD to other fundamental photophysical effects such as the circular dichroism in angular distributions (CDAD). Accordingly, distinct spatial orientations of a chiral molecule enhance the PECD by a factor of about 10.
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- 2017
- Full Text
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20. Human Infections by Non-Rodent-Associated Hantaviruses in Africa.
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Heinemann P, Tia M, Alabi A, Anon JC, Auste B, Essbauer S, Gnionsahe A, Kigninlman H, Klempa B, Kraef C, Kruger N, Leendertz FH, Ndhatz-Sanogo M, Schaumburg F, Witkowski PT, Akoua-Koffi CG, and Kruger DH
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- Animals, Cote d'Ivoire epidemiology, Gabon epidemiology, Humans, Seroepidemiologic Studies, Antibodies, Viral blood, Orthohantavirus immunology, Hantavirus Infections epidemiology, Hantavirus Infections virology
- Abstract
Various hantaviruses have been discovered in unconventional hosts (shrews and bats) in Africa. Up to now, it was unknown whether these viruses pose a threat for human health. In this study, using newly established serological assays, we demonstrated evidence of shrew-borne hantavirus infections in humans from Côte d'Ivoire and Gabon., (© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.)
- Published
- 2016
- Full Text
- View/download PDF
21. The Interplay Between Conformation and Absolute Configuration in Chiral Electron Dynamics of Small Diols.
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Daly S, Tia M, Garcia GA, Nahon L, and Powis I
- Abstract
A competition between chiral characteristics alternatively attributable to either conformation or to absolute configuration is identified. Circular dichroism associated with photoexcitation of the outer orbital of configurational enantiomers of 1,3- and 2,3-butanediols has been examined with a focus on the large changes in electron chiral asymmetry produced by different molecular conformations. Experimental gas-phase measurements offer support for the theoretical modeling of this chiroptical effect. A surprising prediction is that a conformationally produced pseudo-enantiomerism in 1,3-butanediol generates a chiral response in the frontier electron dynamics that outweighs the influence of the permanent configurational handedness established at the asymmetrically substituted carbon. Induced conformation, and specifically induced conformational chirality, may thus be a dominating factor in chiral molecular recognition in such systems., (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
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- 2016
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22. Influence of Leukocyte- and Platelet-Rich Fibrin (L-PRF) in the Healing of Simple Postextraction Sockets: A Split-Mouth Study.
- Author
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Marenzi G, Riccitiello F, Tia M, di Lauro A, and Sammartino G
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- Blood Platelets metabolism, Female, Humans, Leukocytes metabolism, Male, Middle Aged, Mouth physiology, Platelet-Rich Plasma metabolism, Tooth Extraction methods, Blood Platelets physiology, Fibrin metabolism, Leukocytes physiology, Platelet-Rich Plasma physiology, Wound Healing physiology
- Abstract
The aim of this study was to evaluate the effects of leukocyte- and platelet-rich fibrin (L-PRF) on the pain and soft tissue healing after tooth extractions. Twenty-six patients (9 males and 17 females) were treated with multiple extractions (2 to 8), with a total of 108 extractions. This was an exploratory single blinded randomized clinical trial with a split-mouth design. The pain after the surgery was assessed in each patient by the VAS scale (1 to 10) at intervals of 24-48-72-96 hours. The soft tissue healing was clinically evaluated at 3, 7, 14, and 21 days after surgery by the same examiner surgeon, using the modified Healing Index (4 to 12). The mean value of postextraction pain was 3.2 ± 0.3 in the experimental sides and 4.1 ± 0.1 in the control sides. After 7 days from the extractions, the values of modified Healing Index in the experimental and control groups were, respectively, 4.8 ± 0.6 and 5.1 ± 0.9. The use of L-PRF in postextraction sockets filling can be proposed as a useful procedure in order to manage the postoperative pain and to promote the soft tissue healing process, reducing the early adverse effects of the inflammation.
- Published
- 2015
- Full Text
- View/download PDF
23. VUV photodynamics and chiral asymmetry in the photoionization of gas phase alanine enantiomers.
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Tia M, Cunha de Miranda B, Daly S, Gaie-Levrel F, Garcia GA, Nahon L, and Powis I
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- Aerosols, Photochemical Processes, Photoelectron Spectroscopy, Stereoisomerism, Synchrotrons, Thermodynamics, Ultraviolet Rays, Vacuum, Volatilization, Alanine chemistry, Gases chemistry, Photons
- Abstract
The valence shell photoionization of the simplest proteinaceous chiral amino acid, alanine, is investigated over the vacuum ultraviolet region from its ionization threshold up to 18 eV. Tunable and variable polarization synchrotron radiation was coupled to a double imaging photoelectron/photoion coincidence (i(2)PEPICO) spectrometer to produce mass-selected threshold photoelectron spectra and derive the state-selected fragmentation channels. The photoelectron circular dichroism (PECD), an orbital-sensitive, conformer-dependent chiroptical effect, was also recorded at various photon energies and compared to continuum multiple scattering calculations. Two complementary vaporization methods-aerosol thermodesorption and a resistively heated sample oven coupled to an adiabatic expansion-were applied to promote pure enantiomers of alanine into the gas phase, yielding neutral alanine with different internal energy distributions. A comparison of the photoelectron spectroscopy, fragmentation, and dichroism measured for each of the vaporization methods was rationalized in terms of internal energy and conformer populations and supported by theoretical calculations. The analytical potential of the so-called PECD-PICO detection technique-where the electron spectroscopy and circular dichroism can be obtained as a function of mass and ion translational energy-is underlined and applied to characterize the origin of the various species found in the experimental mass spectra. Finally, the PECD findings are discussed within an astrochemical context, and possible implications regarding the origin of biomolecular asymmetry are identified.
- Published
- 2014
- Full Text
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24. A photoionization investigation of small, homochiral clusters of glycidol using circularly polarized radiation and velocity map electron-ion coincidence imaging.
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Powis I, Daly S, Tia M, de Miranda BC, Garcia GA, and Nahon L
- Abstract
A detailed study of the valence photoionization of small homochiral glycidol (C3O2H6) clusters is carried out with the help of circularly-polarized VUV synchrotron radiation by recording photoionization-based spectroscopic data detected by velocity map electron imaging with coincidence ion selection. We show that information on the stability of cationic as well as neutral chiral clusters can be obtained with enhanced sensitivity by examining the chiral fingerprint encapsulated in Photoelectron Circular Dichroism (PECD) spectra. In particular, by varying the clustering conditions we demonstrate that the PECD signal effectively carries the signature of the neutral precursor species, prior to any fragmentation of the ion, as may be inferred from the below-threshold monomer measurements (including ion imaging). Here the monomer's direct ionization channel is closed and the monomer ion hence must result exclusively as a fragment from dissociative ionization of the dimer (or higher) clusters. At higher photon energies, the mass-selection on the electron spectroscopy data, achieved through filtering the electron images in coincidence with selected ion masses, evidently succeeds in providing a degree of size-selection on the neutral clusters being ionized with, in particular, a clear differentiation of monomer and dimer PECD, showing the strong sensitivity of this chiroptical effect to the non-local long-range molecular potential.
- Published
- 2014
- Full Text
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25. Growth-promoting action and growth factor release by different platelet derivatives.
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Passaretti F, Tia M, D'Esposito V, De Pascale M, Del Corso M, Sepulveres R, Liguoro D, Valentino R, Beguinot F, Formisano P, and Sammartino G
- Subjects
- Adult, Cell Proliferation drug effects, Cytokines metabolism, Female, Fibroblasts drug effects, Fibroblasts metabolism, Human Umbilical Vein Endothelial Cells drug effects, Human Umbilical Vein Endothelial Cells metabolism, Humans, Intercellular Signaling Peptides and Proteins pharmacology, Male, Young Adult, Blood Platelets physiology, Intercellular Signaling Peptides and Proteins metabolism, Platelet-Rich Plasma
- Abstract
Abstract Platelet derivatives are commonly used in wound healing and tissue regeneration. Different procedures of platelet preparation may differentially affect growth factor release and cell growth. Preparation of platelet-rich fibrin (PRF) is accompanied by release of growth factors, including platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and transforming growth factor β1 (TGFβ1), and several cytokines. When compared with the standard procedure for platelet-rich plasma (PRP), PRF released 2-fold less PDGF, but >15-fold and >2-fold VEGF and TGFβ1, respectively. Also, the release of several cytokines (IL-4, IL-6, IL-8, IL-10, IFNγ, MIP-1α, MIP-1β and TNFα) was significantly increased in PRF-conditioned medium (CM), compared to PRP-CM. Incubation of both human skin fibroblasts and human umbilical vein endothelial cells (HUVECs) with PRF-derived membrane (mPRF) or with PRF-CM enhanced cell proliferation by >2-fold (p<0.05). Interestingly, PRP elicited fibroblast growth at a higher extent compared to PRF. At variance, PRF effect on HUVEC growth was significantly greater than that of PRP, consistent with a higher concentration of VEGF in the PRF-CM. Thus, the procedure of PRP preparation leads to a larger release of PDGF, as a possible result of platelet degranulation, while PRF enhances the release of proangiogenic factors.
- Published
- 2014
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26. DELICIOUS III: a multipurpose double imaging particle coincidence spectrometer for gas phase vacuum ultraviolet photodynamics studies.
- Author
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Garcia GA, Cunha de Miranda BK, Tia M, Daly S, and Nahon L
- Abstract
We present a versatile double imaging particle coincidence spectrometer operating in fully continuous mode, named DELICIOUS III, which combines a velocity map imaging device and a modified Wiley-McLaren time of flight momentum imaging analyzer for photoelectrons and photoions, respectively. The spectrometer is installed in a permanent endstation on the DESIRS vacuum ultraviolet (VUV) beamline at the French National Synchrotron Radiation Facility SOLEIL, and is dedicated to gas phase VUV spectroscopy, photoionization, and molecular dynamics studies. DELICIOUS III is capable of recording mass-selected threshold photoelectron photoion coincidence spectra with a sub-meV resolution, and the addition of a magnifying lens inside the electron drift tube provides a sizeable improvement of the electron threshold/ion mass resolution compromise. In fast electron mode the ultimate kinetic energy resolution has been measured at ΔE/E = 4%. The ion spectrometer offers a mass resolution--full separation of adjacent masses--of 250 amu for moderate extraction fields and the addition of an electrostatic lens in the second acceleration region allows measuring the full 3D velocity vector for a given mass with an ultimate energy resolution of ΔE/E = 15%, without sacrificing the mass resolution. Hence, photoelectron images are correlated both to the mass and to the ion kinetic energy and recoil direction, to access the electron spectroscopy of size-selected species, to study the photodissociation processes of state-selected cations in detail, or to measure in certain cases photoelectron angular distributions in the ion recoil frame. The performances of DELICIOUS III are explored through several examples including the photoionization of N2, NO, and CF3.
- Published
- 2013
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27. Adverse reaction to irrigation with povidone-iodine after deep-impacted, lower third molar extraction.
- Author
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Sammartino G, Tia M, Tete S, Perillo L, and Trosino O
- Subjects
- Adult, Humans, Male, Surgical Wound Dehiscence complications, Therapeutic Irrigation adverse effects, Tooth, Impacted, Anti-Infective Agents, Local adverse effects, Molar, Third surgery, Povidone-Iodine adverse effects, Therapeutic Irrigation methods, Tooth Extraction adverse effects
- Abstract
Povidone-iodine is most commonly used worldwide because of its germicidal activity, relatively low irritancy or toxicity and low cost. Frequently, povidone-iodine is used as a topical antiseptic for treating and preventing wound infection. In rare cases skin irritation or iododerma-like eruption could represent possible adverse effects due to the oxidative effects of iodine and allergic hypersensitivity reaction. In this report we describe a case of a massive adverse reaction to the irrigation of surgical wound dehiscence with 10 percent povidone-iodine solution after deep-impacted, lower third molar extraction. This reaction was related to a central neurotrophic reflex involving three trigeminal branches and probably due to peripheral chemical insult of mandible nerve. This adverse reaction determined a severe edema and diffuse skin lesions, involving the whole left side of the face mimicking an iododerma-like eruption. These violent symptoms were solved after 60 days. Furthermore, we report a small permanent skin scar in the zygomatic area and transient alterations of facial sensitivity on the affected side which completely disappeared in 6 months.
- Published
- 2012
28. Prevention of hemorrhagic complications after dental extractions into open heart surgery patients under anticoagulant therapy: the use of leukocyte- and platelet-rich fibrin.
- Author
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Sammartino G, Dohan Ehrenfest DM, Carile F, Tia M, and Bucci P
- Subjects
- Aged, Blood Platelets, Female, Humans, Leukocytes, Male, Middle Aged, Oral Hemorrhage prevention & control, Anticoagulants therapeutic use, Dental Care for Chronically Ill, Fibrin therapeutic use, Heart Valve Prosthesis, Hemostatics therapeutic use, Postoperative Hemorrhage prevention & control, Tooth Extraction
- Abstract
Leukocyte- and platelet-rich fibrin (L-PRF) is a biomaterial commonly used in periodontology and implant dentistry to improve healing and tissue regeneration, particularly as filling material in alveolar sockets to regenerate bone for optimal dental implant placement. The objective of this work was to evaluate the use of L-PRF as a safe filling and hemostatic material after dental extractions (or avulsions) for the prevention of hemorrhagic complications in heart surgery patients without modification of the anticoagulant oral therapy. Fifty heart surgery patients under oral anticoagulant therapy who needed dental extractions were selected for the study. Patients were treated with L-PRF clots placed into 168 postextraction sockets without modification of anticoagulant therapy (mean international normalized ratio = 3.16 ± 0.39). Only 2 patients reported hemorrhagic complications (4%), all of which resolved a few hours after the surgery by compression and hemostatic topical agents. Ten patients (20%) showed mild bleeding, which spontaneously resolved or was resolved by minimal compression less than 2 hours after surgery. No case of delayed bleeding was reported. The remaining 38 patients (76%) showed an adequate hemostasis after the dental extractions. In all cases, no alveolitis or painful events were reported, soft tissue healing was quick, and wound closure was always complete at the time of suture removal one week after surgery. The proposed protocol is a reliable therapeutic option to avoid significant bleeding after dental extractions without the suspension of the continuous oral anticoagulant therapy in heart surgery patients. Other applications of the hemostatic and healing properties of L-PRF should be investigated in oral implantology.
- Published
- 2011
- Full Text
- View/download PDF
29. Tooth replantation as an alternative to dental implantology in adolescent patients.
- Author
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Ferrazzano GF, Orlando S, Ingenito A, Tia M, and Sammartino G
- Subjects
- Adolescent, Contraindications, Dental Implants, Female, Humans, Incisor injuries, Nasal Bone injuries, Periodontal Splints, Retrograde Obturation, Skull Fractures complications, Tooth Avulsion etiology, Tooth Avulsion surgery, Tooth Extraction, Tooth Replantation
- Abstract
Background: A 16-years old female patient was referred to our observation in July 2006, 14 days after an accident, with traumatic intrusive luxation of the right upper central incisor that caused the nasal floor and buccal cortical bone fracture. While the extraoral examination showed the traumatic lesions of the upper lip, the intraoral examination revealed intrusive luxation, pain and high mobility of the tooth, and bleeding of the adjacent oral tissue. The treatment protocol consisted in surgical buccal bone removal, tooth extraction, retrograde root-canal filling, and tooth repositioning in occlusion with a resilient splinting. After 8 weeks the splinting was removed, and clinical and radiological examinations were taken 3, 6, 9, 12, and 24 months after surgery. At the 24 months follow-up the root showed no radiographic signs of inflammation, resorption or ankylosis, and the function of the replanted tooth was fully maintained. Tooth replantation can be considered an effective alternative to dental implant, when the latter is contraindicated in young patient with incomplete skeletal development. The long-term success of the procedure will likely require a multidisciplinary approach.
- Published
- 2010
30. Platelet-rich plasma and resorbable membrane for prevention of periodontal defects after deeply impacted lower third molar extraction.
- Author
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Sammartino G, Tia M, Gentile E, Marenzi G, and Claudio PP
- Subjects
- Adult, Alveolar Bone Loss etiology, Alveolar Bone Loss prevention & control, Animals, Biological Dressings, Female, Follow-Up Studies, Guided Tissue Regeneration, Periodontal methods, Humans, Male, Mandible, Membranes, Artificial, Molar, Third surgery, Periodontal Pocket complications, Periodontal Pocket etiology, Root Resorption etiology, Single-Blind Method, Statistics, Nonparametric, Swine, Tooth Extraction adverse effects, Tooth Extraction methods, Tooth, Impacted surgery, Treatment Outcome, Wound Healing drug effects, Wound Healing physiology, Young Adult, Biocompatible Materials therapeutic use, Bone Regeneration drug effects, Collagen therapeutic use, Platelet-Rich Plasma physiology, Root Resorption prevention & control, Tooth Socket drug effects
- Abstract
Purpose: The extraction of deeply included third molars may cause multiple periodontal defects at the distal root of the second molar. Platelet-rich plasma (PRP) is a material containing autologous growth factors, which may be used in repairing and preventing periodontal complications at the distal root of the second molar adjacent to the extracted third molar. We have previously analyzed the effects of autologous PRP on periodontal tissues after extraction of the third molar in 18 young patients. In the current study, we investigated the clinical effects of a resorbable collagen membrane of porcine origin (Bio-Gide; Geistlich Biomaterials, Wolhusen, Switzerland) associated with PRP on bone regeneration after surgical avulsion of the inferior third molars in mesio-horizontal inclusion in comparison with the use of PRP alone., Materials and Methods: Inclusion criteria were the presence of a pocket distal to the mandibular second molar with a probing depth greater than or equal to 7.5 mm and a probing attachment level greater than or equal to 6 mm, and a postextraction defect presenting with the vestibular and lingual cortical bone intact., Results and Conclusions: We show that although clinical results from the comparison of PRP alone versus PRP and resorbable membrane can be considered similar, from a histologic point of view, the association of PRP to Bio-Gide membrane showed earlier signs of bone maturation but not a higher grade of bone regeneration.
- Published
- 2009
- Full Text
- View/download PDF
31. Prevention of mandibular third molar extraction-associated periodontal defects: a comparative study.
- Author
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Sammartino G, Tia M, Bucci T, and Wang HL
- Subjects
- Adult, Biocompatible Materials therapeutic use, Bone Matrix transplantation, Bone Substitutes therapeutic use, Collagen, Dental Plaque Index, Female, Follow-Up Studies, Gingival Recession prevention & control, Guided Tissue Regeneration, Periodontal methods, Humans, Male, Mandible surgery, Membranes, Artificial, Minerals therapeutic use, Periodontal Attachment Loss prevention & control, Periodontal Index, Periodontal Pocket prevention & control, Treatment Outcome, Young Adult, Molar, Third surgery, Periodontal Diseases prevention & control, Postoperative Complications prevention & control, Tooth Extraction adverse effects, Tooth, Impacted surgery
- Abstract
Background: Extraction of deep-impacted mandibular third molars may lead to periodontal defects at the distal surface of the adjacent second molar. The purpose of this study was to compare the ability of three regenerative approaches to prevent third molar extraction-related periodontal defects., Methods: Forty-five patients with bilateral osseous or soft tissue-impacted lower third molars were selected to participate in the study. Inclusion criteria were the presence of a pocket that was located distally to the mandibular second molar with a probing depth (PD) >or=7 mm and with a probing clinical attachment level (CAL) >or=6 mm. Ninety third molar impactions were used and were randomly assigned to three equal treatment groups (30 each): bovine porous bone mineral (BPBM) alone, BPBM plus collagen membrane (CM), and an untreated control group. Clinical and radiographic measurements were recorded at 3, 6, 9, 12, 18, 24, 36, 48, 60, and 72 months after the surgery., Results: BPBM or BPBM + CM resulted in a significant reduction in PD and gain in CAL compared to the control group at all time points. BPBM + CM had the best outcome for the prevention of a second-molar periodontal defect., Conclusion: The application of BPBM, with or without a collagen membrane, can be a viable and stable treatment to alleviate the periodontal defects that are often associated with impacted mandibular third molar extractions.
- Published
- 2009
- Full Text
- View/download PDF
32. High failure rate of first arterio-venous fistula in patients starting hemodialysis treatment: a report from the Ivory Coast.
- Author
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Ackoundou-N'Guessan C, Gnionsahe A, Guei M, Sayegh M, Kossi S, Tia M, and Sissoko DL
- Subjects
- Adult, Cote d'Ivoire, Female, Humans, Male, Retrospective Studies, Treatment Failure, Arteriovenous Shunt, Surgical, Renal Dialysis
- Abstract
This study was conducted in order to identify the failure rate of the first arterio-venous fistula (AVF) in patients starting hemodialysis (HD) with a central venous catheter (CVC) and to search for factors responsible for this failure. A retrospective study was conducted on 85 patients on chronic HD in Abidjan, from March 15 th to April 15 th , 2007. Factors that could potentially influence the failure of the first AVF were collected. Statistical analysis was used for comparison between groups. Among the study subjects, 7.14% had AVF at the start of their dialysis as against 92.86% who had CVC. About 50% of the patients starting dialysis with CVC failed to have an AVF created within 90 days of commencing dialysis. The number of catheters inserted was significantly higher in patients with failed first AVF as compared to their counterparts (49.29 % versus 30.77%) (p< 0.001). Similarly, the number of attempts at AVF creation, within 90 days of starting HD, was significantly higher in patients with failed first AVF (81.48% versus 18.52%) (p< 0.001). Multivariate analysis did not reveal any specific factor(s) that influenced the failure rate of the first AVF. Our study suggests that a very small number of patients in Ivory Coast started dialysis with an AVF. The failure rate of the first AVF in patients starting dialysis on CVC is about 50%.
- Published
- 2008
33. The usefulness of 111indium-oxine autologous platelet gel graft imaging to evaluate osteoinduction in patients undergoing surgery of jaw bone defects.
- Author
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Sammartino G, Celentano L, Tia M, D'Agostino E, Fusco A, Tetè S, and Ottiero M
- Subjects
- Adult, Female, Humans, Image Processing, Computer-Assisted, Indium Radioisotopes, Jaw Abnormalities surgery, Male, Molar, Third surgery, Radionuclide Imaging, Tooth Extraction, Blood Platelets chemistry, Bone Remodeling immunology, Bone Remodeling physiology, Indium, Jaw Abnormalities diagnostic imaging, Radiopharmaceuticals
- Abstract
Autologous platelet gel (AGP) is a source of concentrated growth factors contained in the platelet granules used to enhance bone quality and, especially, quicken bone formation in regeneration techniques, and also ameliorate the haemostasis in anti-coagulated patient management. The purpose of this study is to describe a technique to perform labelling of autologous platelet-gel with 111In -Oxine and to evaluate its usefulness, as a marker of bone osteoinduction by means of scintigraphy, after in vivo application in patients with jaw bone defects following cystic lesion enucleation and the extraction of deeply impacted lower third molar. All patients included in the study presented mandible bone defects following cyst enucleation or deeply impacted lower third molar extraction. In sterile conditions, 111In-Oxine AGP was added during the bone-milling phase of the graft preparation and then applied to the bone defects. The scintigraphy was performed 2 hours after the application of labelled AGP (early scan) and at 24, 48, 72, 384 hours (delayed scan). At early scan all the patients presented a high concentration of 111In-Oxine AGP, which was easily recognized at the level of jaw defect. Limited diffusion of AGP was seen in the tissue surrounding the bone defect; this activity was attributed to the presence, in the PRP, of a quote of autologous granulocytes, as marker of inflammatory process, which was labelled with 111In-Oxine. In order to demonstrate the persistence and stability of labelling AGP, abdominal scintigraphies were performed to assess the presence of activity in the liver, spleen and bone marrow. None of the patients presented appreciable activity in these organs. The labelled AGP topically applied showed high uptake values, without statistically significant activity in the surrounding tissues or in critical organs during the early phase, as well as in delayed controls, and confirmed a very low grade of loss of 111In-Oxine from the bone defect. The scintigraphy represents a useful method of assessing the success of surgical procedure for jaw bone defects performed with autogenous grafts. It is well accepted by the patients, offering at the same time a sensitive method of studying uptake of topically applied AGP and to follow up kinetics of AGP in order to correlate quantitative data of the platelet gel life span with evolution of the bone remodelling process. Finally, the labelled granulocytes around the bone defect allow to assess the inflammatory process evolution derived from the surgical technique.
- Published
- 2008
- Full Text
- View/download PDF
34. [Characteristics of potential living kidney donors in Ivory Coast: a survey prior to a project of kidney transplantation in French Black Africa].
- Author
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Ackoundou-N'guessan C, Gnionsahe A, Kouame E, Lagou D, Tia M, Sissoko H, and Guei M
- Subjects
- Adult, Africa, Northern, Attitude, Cote d'Ivoire, Data Collection, Feasibility Studies, Female, Humans, Living Donors psychology, Living Donors statistics & numerical data, Male, Middle Aged, Sampling Studies, Socioeconomic Factors, Urban Population statistics & numerical data, Kidney Transplantation, Living Donors supply & distribution, Tissue and Organ Procurement statistics & numerical data
- Abstract
The source of living kidney donors in the general population remains underused. The present study aims at assessing the prevalence and the characteristics of potential living kidney donors in Ivory Coast in a view of a project of kidney transplantation in French Black Africa. A survey was undertaken in Abidjan from 30 June to 7 July 2006. Nine hundred (and) sixty-two subjects living in the capital and aged between 19 and 64 years old were randomly chosen using data from the 1998 population census. Subjects were asked their age, gender, nationality, marital status, information on kidney graft and renal failure, and their willingness to donate kidney to a relative or friend for transplantation purpose. Seventy per cent of the population study appeared favourable to kidney donation. Potentials living kidney donors have displayed following characteristics: age inferior to 26 years old [OR=2.08, P<0.02, 95%CI: 1.10-3.92]; Ivorians national [OR=2.72, P<0.002, 95% CI 1.42-5.21]; having heard of kidney transplantation (OR=1.89, P<0.047, 95% CI 1-3.54]); the death of a relative or friend from renal failure [OR=1.82, P<0.002, 95% CI 1.25 2.67]. Being married adversely affect kidney donation [OR=0.52, P<0.0002, 95% CI 0.34-0.79]. Potentials living kidney donors are in great number in Ivory Coast, who had specific characteristics.
- Published
- 2007
- Full Text
- View/download PDF
35. Use of autologous platelet-rich plasma (PRP) in periodontal defect treatment after extraction of impacted mandibular third molars.
- Author
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Sammartino G, Tia M, Marenzi G, di Lauro AE, D'Agostino E, and Claudio PP
- Subjects
- Adult, Alveolar Bone Loss etiology, Female, Humans, Male, Mandible surgery, Periodontal Pocket complications, Periodontal Pocket etiology, Plasmapheresis, Tooth, Impacted surgery, Alveolar Bone Loss drug therapy, Blood Platelets, Bone Regeneration drug effects, Growth Substances administration & dosage, Molar, Third surgery, Tooth Extraction adverse effects
- Abstract
Purpose: The extraction of mesioangular impacted third molars may cause multiple periodontal defects at the distal root of the second molar. Platelet-rich plasma (PRP) is a material containing many autologous growth factors that may be used in repairing and preventing periodontal complications at the distal root of the second molar adjacent to the extracted third molar., Patients and Methods: We analyzed the effects of autologous PRP on periodontal tissues after extraction of the third molar in 18 young patients (age, 21-26 years). Inclusion criteria were the presence of a pocket distal to the mandibular second molar with a probing depth>or=7.5 mm and a probing attachment level>or=6 mm., Results: We observed, at 12 weeks after surgery, a notable reduction in the probing depth and an improvement in the probing attachment level in those cases treated with PRP compared with the controls, as well as formation of new bone tissue in the bone defect., Conclusion: We showed that PRP is effective in inducing and accelerating bone regeneration for the treatment of periodontal defects at the distal root of the mandibular second molar after surgical extraction of a mesioangular, deeply impacted mandibular third molar.
- Published
- 2005
- Full Text
- View/download PDF
36. Prevention of postoperative bleeding in anticoagulated patients undergoing oral surgery: use of platelet-rich plasma gel.
- Author
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Della Valle A, Sammartino G, Marenzi G, Tia M, Espedito di Lauro A, Ferrari F, and Lo Muzio L
- Subjects
- Adult, Aged, Alveolar Process pathology, Female, Heart Valve Prosthesis, Hemostatics therapeutic use, Humans, International Normalized Ratio, Male, Middle Aged, Plasma, Tooth Extraction, Tooth Socket pathology, Treatment Outcome, Warfarin therapeutic use, Anticoagulants therapeutic use, Oral Hemorrhage prevention & control, Platelet Transfusion, Postoperative Hemorrhage prevention & control
- Abstract
Purpose: This study evaluated the effectiveness of a protocol using platelet-rich plasma (PRP) to prevent bleeding after dental extraction in patients treated with anticoagulant oral therapy., Materials and Methods: Forty patients with mechanical heart-value replacement who were treated with anticoagulant oral therapy were selected for the study. Each patient was treated with PRP gel placed into residual alveolar bone after extraction without heparin administration after suspension of oral anticoagulant drugs (36 hours)., Results: Only 2 patients reported hemorrhagic complications (5%). Sixteen patients (40%) had mild bleeding that was easy to control with hemostatic topical agents; this mild bleeding terminated completely 1 to 3 days after the surgical procedures. The remaining 22 patients (55%) presented with adequate hemostasis., Conclusions: Oral surgery in heart surgical patients under oral anticoagulant therapy may be facilitated with PRP gel. Its use is an advanced and safe procedure. This biological and therapeutical improvement can simplify systemic management and help avoid hemorrhagic and/or thromboembolic complications.
- Published
- 2003
- Full Text
- View/download PDF
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