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7. Tensor-to-scalar ratio forecasts for extended LiteBIRD frequency configurations

Author

U. Fuskeland, J. Aumont, R. Aurlien, C. Baccigalupi, A. J. Banday, H. K. Eriksen, J. Errard, R. T. Génova-Santos, T. Hasebe, J. Hubmayr, H. Imada, N. Krachmalnicof, L. Lamagna, G. Pisano, D. Poletti, M. Remazeilles, K. L. Thompson, L. Vache, I. K. Wehus, S. Azzoni, M. Ballardini, R. B. Barreiro, N. Bartolo, A. Basyrov, D. Beck, M. Bersanelli, M. Bortolami, M. Brilenkov, E. Calabrese, A. Carones, F. J. Casas, K. Cheung, J. Chluba, S. E. Clark, L. Clermont, and E.J. Wollack

Subjects
Space Sciences (General)
Abstract

LiteBIRD is a planned JAXA-led cosmic microwave background (CMB) B-mode satellite experiment aiming for launch in the late 2020s, with a primary goal of detecting the imprint of primordial inflationary gravitational waves. Its current baseline focal-plane configuration includes 15 frequency bands between 40 and 402 GHz, fulfilling the mission requirements to detect the amplitude of gravitational waves with the total uncertainty on the tensor-to-scalar ratio, δr, down to δr < 0.001. A key aspect of this performance is accurate astrophysical component separation, and the ability to remove polarized thermal dust emission is particularly important. In this paper we note that the CMB frequency spectrum falls off nearly exponentially above 300 GHz relative to the thermal dust spectral energy distribution, and a relatively minor high frequency extension can therefore result in even lower uncertainties and better model reconstructions. Specifically, we compared the baseline design with five extended configurations, while varying the underlying dust modeling, in each of which the High-Frequency Telescope (HFT) frequency range was shifted logarithmically toward higher frequencies, with an upper cutoff ranging between 400 and 600 GHz. In each case, we measured the tensor-to-scalar ratio r uncertainty and bias using both parametric and minimum-variance component-separation algorithms. When the thermal dust sky model includes a spatially varying spectral index and temperature, we find that the statistical uncertainty on r after foreground cleaning may be reduced by as much as 30–50% by extending the upper limit of the frequency range from 400 to 600 GHz, with most of the improvement already gained at 500 GHz. We also note that a broader frequency range leads to higher residuals when fitting an incorrect dust model, but also it is easier to discriminate between models through higher χ2 sensitivity. Even in the case in which the fitting procedure does not correspond to the underlying dust model in the sky, and when the highest frequency data cannot be modeled with sufficient fidelity and must be excluded from the analysis, the uncertainty on r increases by only about 5% for a 500 GHz configuration compared to the baseline.

Published
2023
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9. Planck 2018 results

Author

Y. Akrami, M. Ashdown, J. Aumont, C. Baccigalupi, M. Ballardini, A. J. Banday, R. B. Barreiro, N. Bartolo, S. Basak, K. Benabed, M. Bersanelli, P. Bielewicz, J. J. Bock, J. R. Bond, J. Borrill, F. R. Bouchet, F. Boulanger, M. Bucher, C. Burigana, R. C. Butler, E. Calabrese, J.-F. Cardoso, B. Casaponsa, H. C. Chiang, L. P. L. Colombo, C. Combet, D. Contreras, B. P. Crill, P. de Bernardis, G. de Zot

Published
2020
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10. Planck intermediate results

Author

Y. Akrami, K. J. Andersen, M. Ashdown, C. Baccigalupi, M. Ballardini, A. J. Banday, R. B. Barreiro, N. Bartolo, S. Basak, K. Benabed, J.-P. Bernard, M. Bersanelli, P. Bielewicz, J. R. Bond, J. Borrill, C. Burigana, R. C. Butler, E. Calabrese, B. Casaponsa, H. C. Chiang, L. P. L. Colombo, C. Combet, B. P. Crill, F. Cuttaia, P. de Bernardis, A. de Rosa, G. de Zotti, J. Delabrouille, E. Di Valentino

Published
2020
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11. In vitro culture to improve breeding activities inRosa hybrida

Author

Matteo Caser, Andrea Mansuino, Valentina Scariot, M. Ballardini, G.G. Ghione, A. Cassetti, and A. Giovannini

Subjects
acclimatization, seedling development, Horticulture, morphological traits, Botany, Rosa hybrida, in vitro rooting, Biology, Acclimatization, acclimatization, in vitro rooting, in vitro shoot multiplication, morphological traits, seedling development, in vitro shoot multiplication
Published
2017
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12. Exploring cosmic origins with CORE: Inflation

Author

F. Finelli, M. Bucher, A. Achúcarro, M. Ballardini, N. Bartolo, D. Baumann, S. Clesse, J. Errard, W. Handley, M. Hindmarsh, K. Kiiveri, M. Kunz, A. Lasenby, M. Liguori, D. Paoletti, C. Ringeval, J. Väliviita, B. van Tent, V. Vennin, P. Ade, R. Allison, F. Arroja, M. Ashdown, A.J. Banday, R. Banerji, J.G. Bartlett, S. Basak, P. de Bernardis, M. Bersanelli, A. Bonaldi, J. Borril, F.R. Bouchet, F. Boulanger, T. Brinckmann, C. Burigana, A. Buzzelli, Z.-Y. Cai, M. Calvo, C.S. Carvalho, G. Castellano, A. Challinor, J. Chluba, I. Colantoni, A. Coppolecchia, M. Crook, G. D'Alessandro, G. D'Amico, J. Delabrouille, V. Desjacques, G. De Zotti, J.M. Diego, E. Di Valentino, S. Feeney, J.R. Fergusson, R. Fernandez-Cobos, S. Ferraro, F. Forastieri, S. Galli, J. García-Bellido, G. de Gasperis, R.T. Génova-Santos, M. Gerbino, J. González-Nuevo, S. Grandis, J. Greenslade, S. Hagstotz, S. Hanany, D.K. Hazra, C. Hernández-Monteagudo, C. Hervias-Caimapo, M. Hills, E. Hivon, B. Hu, T. Kisner, T. Kitching, E.D. Kovetz, H. Kurki-Suonio, L. Lamagna, M. Lattanzi, J. Lesgourgues, A. Lewis, V. Lindholm, J. Lizarraga, M. López-Caniego, G. Luzzi, B. Maffei, N. Mandolesi, E. Martínez-González, C.J.A.P. Martins, S. Masi, D. McCarthy, S. Matarrese, A. Melchiorri, J.-B. Melin, D. Molinari, A. Monfardini, P. Natoli, M. Negrello, A. Notari, F. Oppizzi, A. Paiella, E. Pajer, G. Patanchon, S.P. Patil, M. Piat, G. Pisano, L. Polastri, G. Polenta, A. Pollo, V. Poulin, M. Quartin, A. Ravenni, M. Remazeilles, A. Renzi, D. Roest, M. Roman, J.A. Rubiño-Martin, L. Salvati, A.A. Starobinsky, A. Tartari, G. Tasinato, M. Tomasi, J. Torrado, N. Trappe, T. Trombetti, M. Tucci, C. Tucker, J. Urrestilla, R. van de Weygaert, P. Vielva, N. Vittorio, K. Young, M. Zannoni, ITA, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut Lagrange de Paris, Sorbonne Université (SU), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Théorique d'Orsay [Orsay] (LPT), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut Nanosciences et Cryogénie (INAC), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Département de Physique des Particules (ex SPP) (DPP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Néel (NEEL), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire d'Annecy-le-Vieux de Physique Théorique (LAPTH), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), CORE, Department of Physics, Helsinki Institute of Physics, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Sorbonne Universités, Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université Grenoble Alpes (UGA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Finelli, F, Bucher, M, Achúcarro, A, Ballardini, M, Bartolo, N, Baumann, D, Clesse, S, Errard, J, Handley, W, Hindmarsh, M, Kiiveri, K, Kunz, M, Lasenby, A, Liguori, M, Paoletti, D, Ringeval, C, Väliviita, J, Tent, B, Vennin, V, Ade, P, Allison, R, Arroja, F, Ashdown, M, Banday, A, Banerji, R, Bartlett, J, Basak, S, de Bernardis, P, Bersanelli, M, Bonaldi, A, Borril, J, Bouchet, F, Boulanger, F, Brinckmann, T, Burigana, C, Buzzelli, A, Cai, Z, Calvo, M, Carvalho, C, Castellano, G, Challinor, A, Chluba, J, Colantoni, I, Coppolecchia, A, Crook, M, D'Alessandro, G, D'Amico, G, Delabrouille, J, Desjacques, V, Zotti, G, Diego, J, Valentino, E, Feeney, S, Fergusson, J, Fernandez-Cobos, R, Ferraro, S, Forastieri, F, Galli, S, García-Bellido, J, de Gasperis, G, Génova-Santos, R, Gerbino, M, González-Nuevo, J, Grandis, S, Greenslade, J, Hagstotz, S, Hanany, S, Hazra, D, Hernández-Monteagudo, C, Hervias-Caimapo, C, Hills, M, Hivon, E, Hu, B, Kisner, T, Kitching, T, Kovetz, E, Kurki-Suonio, H, Lamagna, L, Lattanzi, M, Lesgourgues, J, Lewis, A, Lindholm, V, Lizarraga, J, López-Caniego, M, Luzzi, G, Maffei, B, Mandolesi, N, Martínez-González, E, Martins, C, Masi, S, Mccarthy, D, Matarrese, S, Melchiorri, A, Melin, J, Molinari, D, Monfardini, A, Natoli, P, Negrello, M, Notari, A, Oppizzi, F, Paiella, A, Pajer, E, Patanchon, G, Patil, S, Piat, M, Pisano, G, Polastri, L, Polenta, G, Pollo, A, Poulin, V, Quartin, M, Ravenni, A, Remazeilles, M, Renzi, A, Roest, D, Roman, M, Rubiño-Martin, J, Salvati, L, Starobinsky, A, Tartari, A, Tasinato, G, Tomasi, M, Torrado, J, Trappe, N, Trombetti, T, Tucci, M, Tucker, C, Urrestilla, J, de Weygaert, R, Vielva, P, Vittorio, N, Young, K, Zannoni, M, Finelli F., Bucher M., Achucarro A., Ballardini M., Bartolo N., Baumann D., Clesse S., Errard J., Handley W., Hindmarsh M., Kiiveri K., Kunz M., Lasenby A., Liguori M., Paoletti D., Ringeval C., Valiviita J., Tent B.V., Vennin V., Ade P., Allison R., Arroja F., Ashdown M., Banday A.J., Banerji R., Bartlett J.G., Basak S., De Bernardis P., Bersanelli M., Bonaldi A., Borril J., Bouchet F.R., Boulanger F., Brinckmann T., Burigana C., Buzzelli A., Cai Z.-Y., Calvo M., Carvalho C.S., Castellano G., Challinor A., Chluba J., Colantoni I., Coppolecchia A., Crook M., D'Alessandro G., D'Amico G., Delabrouille J., Desjacques V., Zotti G.D., Diego J.M., Valentino E.D., Feeney S., Fergusson J.R., Fernandez-Cobos R., Ferraro S., Forastieri F., Galli S., Garcia-Bellido J., De Gasperis G., Genova-Santos R.T., Gerbino M., Gonzalez-Nuevo J., Grandis S., Greenslade J., Hagstotz S., Hanany S., Hazra D.K., Hernandez-Monteagudo C., Hervias-Caimapo C., Hills M., Hivon E., Hu B., Kisner T., Kitching T., Kovetz E.D., Kurki-Suonio H., Lamagna L., Lattanzi M., Lesgourgues J., Lewis A., Lindholm V., Lizarraga J., Lopez-Caniego M., Luzzi G., Maffei B., Mandolesi N., Martinez-Gonzalez E., Martins C.J.A.P., Masi S., McCarthy D., Matarrese S., Melchiorri A., Melin J.-B., Molinari D., Monfardini A., Natoli P., Negrello M., Notari A., Oppizzi F., Paiella A., Pajer E., Patanchon G., Patil S.P., Piat M., Pisano G., Polastri L., Polenta G., Pollo A., Poulin V., Quartin M., Ravenni A., Remazeilles M., Renzi A., Roest D., Roman M., Rubino-Martin J.A., Salvati L., Starobinsky A.A., Tartari A., Tasinato G., Tomasi M., Torrado J., Trappe N., Trombetti T., Tucci M., Tucker C., Urrestilla J., De Weygaert R.V., Vielva P., Vittorio N., Young K., Zannoni M., String Theory (ITFA, IoP, FNWI), High-Energy Frontier, Astronomy, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Cryogénie (NEEL - Cryo), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Département de Physique des Particules (ex SPP) (DPhP), and Hélium : du fondamental aux applications (NEEL - HELFA)

Subjects
cosmological model, reheating, Cosmic microwave background, cosmic background radiation: polarization, SPECTRAL DISTORTIONS, astro-ph.CO, Astrophysics, cosmic background radiation, 7. Clean energy, 01 natural sciences, GRAVITATIONAL-WAVES, law.invention, law, 010303 astronomy & astrophysics, CMBR theory, ination, Astronomy and Astrophysics, CMBR theory, inflation, QC, QB, Physics, COSMIC cancer database, ST/J005673/1, ST/H008586/1, inflation: model, MICROWAVE BACKGROUND ANISOTROPY, Core inflation, Astrophysics - Cosmology and Nongalactic Astrophysics, Big Bang, scale: grand unified theory, Astrophysics and Astronomy, noise, Cosmology and Nongalactic Astrophysics (astro-ph.CO), STANDARD MODEL, satellite, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, isocurvature: perturbation, frequency: high, PRIMORDIAL NON-GAUSSIANITY, NO, Telescope, power spectrum: primordial, FIS/05 - ASTRONOMIA E ASTROFISICA, Settore FIS/05 - Astronomia e Astrofisica, LARGE-SCALE STRUCTURE, 0103 physical sciences, inflation, cosmic string, STFC, MODEL SELECTION, Inflation (cosmology), non-Gaussianity: primordial, ST/K00333X/1, ISOCURVATURE PERTURBATIONS, 010308 nuclear & particles physics, string tension, big bang, inflation: slow-roll approximation, RCUK, Spectral density, 115 Astronomy, Space science, cosmic background radiation: temperature, Cosmic string, detector: sensitivity, angular resolution, 13. Climate action, PRE-BIG-BANG, BAYESIAN-INFERENCE, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], cosmic background radiation: anisotropy
Abstract

We forecast the scientific capabilities to improve our understanding of cosmic inflation of CORE, a proposed CMB space satellite submitted in response to the ESA fifth call for a medium-size mission opportunity. The CORE satellite will map the CMB anisotropies in temperature and polarization in 19 frequency channels spanning the range 60-600 GHz. CORE will have an aggregate noise sensitivity of $1.7 ��$K$\cdot \,$arcmin and an angular resolution of 5' at 200 GHz. We explore the impact of telescope size and noise sensitivity on the inflation science return by making forecasts for several instrumental configurations. This study assumes that the lower and higher frequency channels suffice to remove foreground contaminations and complements other related studies of component separation and systematic effects, which will be reported in other papers of the series "Exploring Cosmic Origins with CORE." We forecast the capability to determine key inflationary parameters, to lower the detection limit for the tensor-to-scalar ratio down to the $10^{-3}$ level, to chart the landscape of single field slow-roll inflationary models, to constrain the epoch of reheating, thus connecting inflation to the standard radiation-matter dominated Big Bang era, to reconstruct the primordial power spectrum, to constrain the contribution from isocurvature perturbations to the $10^{-3}$ level, to improve constraints on the cosmic string tension to a level below the presumptive GUT scale, and to improve the current measurements of primordial non-Gaussianities down to the $f_{NL}^{\rm local} < 1$ level. For all the models explored, CORE alone will improve significantly on the present constraints on the physics of inflation. Its capabilities will be further enhanced by combining with complementary future cosmological observations., Latex 107 pages, revised with updated author list and minor modifications

Published
2018
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13. Exploring cosmic origins with CORE: Gravitational lensing of the CMB

Author

A. Challinor, R. Allison, J. Carron, J. Errard, S. Feeney, T. Kitching, J. Lesgourgues, A. Lewis, Í. Zubeldía, A. Achucarro, P. Ade, M. Ashdown, M. Ballardini, A.J. Banday, R. Banerji, J. Bartlett, N. Bartolo, S. Basak, D. Baumann, M. Bersanelli, A. Bonaldi, M. Bonato, J. Borrill, F. Bouchet, F. Boulanger, T. Brinckmann, M. Bucher, C. Burigana, A. Buzzelli, Z.-Y. Cai, M. Calvo, C.-S. Carvalho, G. Castellano, J. Chluba, S. Clesse, I. Colantoni, A. Coppolecchia, M. Crook, G. d'Alessandro, P. de Bernardis, G. de Gasperis, G. De Zotti, J. Delabrouille, E. Di Valentino, J.-M. Diego, R. Fernandez-Cobos, S. Ferraro, F. Finelli, F. Forastieri, S. Galli, R. Genova-Santos, M. Gerbino, J. González-Nuevo, S. Grandis, J. Greenslade, S. Hagstotz, S. Hanany, W. Handley, C. Hernandez-Monteagudo, C. Hervías-Caimapo, M. Hills, E. Hivon, K. Kiiveri, T. Kisner, M. Kunz, H. Kurki-Suonio, L. Lamagna, A. Lasenby, M. Lattanzi, M. Liguori, V. Lindholm, M. López-Caniego, G. Luzzi, B. Maffei, E. Martinez-González, C.J.A.P. Martins, S. Masi, S. Matarrese, D. McCarthy, A. Melchiorri, J.-B. Melin, D. Molinari, A. Monfardini, P. Natoli, M. Negrello, A. Notari, A. Paiella, D. Paoletti, G. Patanchon, M. Piat, G. Pisano, L. Polastri, G. Polenta, A. Pollo, V. Poulin, M. Quartin, M. Remazeilles, M. Roman, J.-A. Rubino-Martin, L. Salvati, A. Tartari, M. Tomasi, D. Tramonte, N. Trappe, T. Trombetti, C. Tucker, J. Valiviita, R. Van de Weijgaert, B. van Tent, V. Vennin, P. Vielva, N. Vittorio, K. Young, M. Zannoni, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut Lagrange de Paris, Sorbonne Universités, AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut Néel (NEEL), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Département de Physique des Particules (ex SPP) (DPP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Annecy-le-Vieux de Physique Théorique (LAPTH), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Théorique d'Orsay [Orsay] (LPT), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), CORE, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Sorbonne Université (SU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), Challinor, A, Allison, R, Carron, J, Errard, J, Feeney, S, Kitching, T, Lesgourgues, J, Lewis, A, Zubeldía, Í, Achucarro, A, Ade, P, Ashdown, M, Ballardini, M, Banday, A, Banerji, R, Bartlett, J, Bartolo, N, Basak, S, Baumann, D, Bersanelli, M, Bonaldi, A, Bonato, M, Borrill, J, Bouchet, F, Boulanger, F, Brinckmann, T, Bucher, M, Burigana, C, Buzzelli, A, Cai, Z, Calvo, M, Carvalho, C, Castellano, G, Chluba, J, Clesse, S, Colantoni, I, Coppolecchia, A, Crook, M, D'Alessandro, G, de Bernardis, P, de Gasperis, G, Zotti, G, Delabrouille, J, Valentino, E, Diego, J, Fernandez-Cobos, R, Ferraro, S, Finelli, F, Forastieri, F, Galli, S, Genova-Santos, R, Gerbino, M, González-Nuevo, J, Grandis, S, Greenslade, J, Hagstotz, S, Hanany, S, Handley, W, Hernandez-Monteagudo, C, Hervías-Caimapo, C, Hills, M, Hivon, E, Kiiveri, K, Kisner, T, Kunz, M, Kurki-Suonio, H, Lamagna, L, Lasenby, A, Lattanzi, M, Liguori, M, Lindholm, V, López-Caniego, M, Luzzi, G, Maffei, B, Martinez-González, E, Martins, C, Masi, S, Matarrese, S, Mccarthy, D, Melchiorri, A, Melin, J, Molinari, D, Monfardini, A, Natoli, P, Negrello, M, Notari, A, Paiella, A, Paoletti, D, Patanchon, G, Piat, M, Pisano, G, Polastri, L, Polenta, G, Pollo, A, Poulin, V, Quartin, M, Remazeilles, M, Roman, M, Rubino-Martin, J, Salvati, L, Tartari, A, Tomasi, M, Tramonte, D, Trappe, N, Trombetti, T, Tucker, C, Valiviita, J, de Weijgaert, R, Tent, B, Vennin, V, Vielva, P, Vittorio, N, Young, K, Zannoni, M, Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Helsinki Institute of Physics, Department of Physics, String Theory (ITFA, IoP, FNWI), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Cryogénie (NEEL - Cryo), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Département de Physique des Particules (ex SPP) (DPhP), and Hélium : du fondamental aux applications (NEEL - HELFA)

Subjects
deflection, Cosmic microwave background, cosmic background radiation: polarization, astro-ph.CO, Astrophysics, ST/N000927/1, ST/L000652/1, 7. Clean energy, 01 natural sciences, CMBR polarisation, gravitational lensing, inflation, neutrino masses from cosmology, ART. NO. 023003, estimator, neutrino: mass, 010303 astronomy & astrophysics, Physics, FLUCTUATIONS, GRAVITY-WAVES, Amplitude, non-Gaussianity, galaxy: cluster, Halo, gravitational radiation: power spectrum, Neutrino, CMBR polarization, gravitational lensing, ination, neutrino masses from cosmology, Astronomy and Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics, CMBR polarisation, noise, Cosmology and Nongalactic Astrophysics (astro-ph.CO), B-mode: lens, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, MASS, NO, FIS/05 - ASTRONOMIA E ASTROFISICA, Settore FIS/05 - Astronomia e Astrofisica, gravitation: lens, 0103 physical sciences, ddc:530, RECONSTRUCTION, inflation, Galaxy cluster, STFC, halo: mass, 010308 nuclear & particles physics, Gravitational wave, gravitational radiation: primordial, RCUK, 115 Astronomy, Space science, redshift, calibration, Redshift, Gravitational lens, CROSS-CORRELATION, RADIATION, neutrino: oscillation, GALAXY CLUSTERS, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], MICROWAVE BACKGROUND POLARIZATION, MATTER
Abstract

Lensing of the CMB is now a well-developed probe of large-scale clustering over a broad range of redshifts. By exploiting the non-Gaussian imprints of lensing in the polarization of the CMB, the CORE mission can produce a clean map of the lensing deflections over nearly the full-sky. The number of high-S/N modes in this map will exceed current CMB lensing maps by a factor of 40, and the measurement will be sample-variance limited on all scales where linear theory is valid. Here, we summarise this mission product and discuss the science that it will enable. For example, the summed mass of neutrinos will be determined to an accuracy of 17 meV combining CORE lensing and CMB two-point information with contemporaneous BAO measurements, three times smaller than the minimum total mass allowed by neutrino oscillations. In the search for B-mode polarization from primordial gravitational waves with CORE, lens-induced B-modes will dominate over instrument noise, limiting constraints on the gravitational wave power spectrum amplitude. With lensing reconstructed by CORE, one can "delens" the observed polarization internally, reducing the lensing B-mode power by 60%. This improves to 70% by combining lensing and CIB measurements from CORE, reducing the error on the gravitational wave amplitude by 2.5 compared to no delensing (in the null hypothesis). Lensing measurements from CORE will allow calibration of the halo masses of the 40000 galaxy clusters that it will find, with constraints dominated by the clean polarization-based estimators. CORE can accurately remove Galactic emission from CMB maps with its 19 frequency channels. We present initial findings that show that residual Galactic foreground contamination will not be a significant source of bias for lensing power spectrum measurements with CORE. [abridged], 44 pages, 12 figures

Published
2018
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14. Planck intermediate results

Author

Y. Akrami, F. Argüeso, M. Ashdown, J. Aumont, C. Baccigalupi, M. Ballardini, A. J. Banday, R. B. Barreiro, N. Bartolo, S. Basak, K. Benabed, J.-P. Bernard, M. Bersanelli, P. Bielewicz, L. Bonavera, J. R. Bond, J. Borrill, F. R. Bouchet, C. Burigana, R. C. Butler, E. Calabrese, J. Carron, H. C. Chiang, C. Combet, B. P. Crill, F. Cuttaia, P. de Bernardis, A. de Rosa, G. de Zotti, J. Delabrouille, and J

Published
2018
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15. NEW GENOTYPES OF HIBISCUS × ROSA-SINENSIS THROUGH CLASSICAL BREEDING AND GENETIC TRANSFORMATION

Author

A. Mercuri, Luca Braglia, F. Nicoletti, C. Bianchini, M. Ballardini, and L. De Benedetti

Subjects
food.ingredient, biology, Agrobacterium, food and beverages, Hibiscus rosa-sinensis, Horticulture, Hibiscus, biology.organism_classification, food, Micropropagation, Plant morphology, Callus, Botany, Cultivar, Cotyledon
Abstract

Since 2006, a breeding programme for Hibiscus rosa-sinensis was established at CRA-FSO, Italy. The aim is to select specific cultivars suitable for pot plant production and well-adapted to the Mediterranean climate. A partial diallelic cross design (reciprocals without self-fecundations) was used to test crossing ability of the collected cultivars. However, only a limited number of cross combinations resulted in progenies with desirable characters. The first selected cultivars are presented. At the same time, we followed another approach to investigate whether desirable morphological modifications (plant size reduction for pot plant cultivation) could be obtained by transforming H. x rosa-sinensis with Agrobacterium rhizogenes. In vitro seedlings were used as sources of explants for the transformation experiments. Two A. rhizogenes strains (ATCC 15834 and NCPPB 1855) were used. Axenic hairy root cultures were established about 4 months after inoculation. Hairy roots grew vigorously on hormone free medium whereas normal roots did not. Transformed roots displayed a typical hairy root phenotype characterized by fast growth, high lateral branching and lack of geotropism. So far, after more than one year of cultivation, a clone of hairy root deriving from a cotyledon formed a friable yellowish callus at root node level and several adventitious buds are spontaneously regenerating from it.

Published
2010
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16. Second-line high-dose chemotherapy in patients with mediastinal and retroperitoneal primary non-seminomatous germ cell tumors: the EBMT experience

Author

C. Taverna, Martin Bornhäuser, Giovanni Rosti, M Ballardini, Wolfgang Siegert, Giorgio Papiani, U. De Giorgi, T. Kozak, Hannes Wandt, Taner Demirer, University of Zurich, and De Giorgi, U

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Databases, Factual, medicine.medical_treatment, 2720 Hematology, 610 Medicine & health, 142-005 142-005, Mediastinal Neoplasms, Disease-Free Survival, High dose chemotherapy, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Retroperitoneal space, In patient, Retroperitoneal Neoplasms, Survival rate, Retrospective Studies, Salvage Therapy, Chemotherapy, business.industry, Mediastinum, Hematology, Middle Aged, Neoplasms, Germ Cell and Embryonal, Prognosis, medicine.disease, Chemotherapy regimen, Surgery, medicine.anatomical_structure, Oncology, 2730 Oncology, Female, Germ cell tumors, Cisplatin, business
Abstract

Background: Results of second-line chemotherapy in patients with extragonadal non-seminomatous germ cell tumor (NSGCT) appear inferior to results in testicular NSGCT. Patients with retroperitoneal NSGCT achieve a comparable long-term survival rate of 30%, but the salvage rates of patients with mediastinal primary are less than 10%. We conducted a retrospective analysis on patients with mediastinal and retroperitoneal NSGCT treated with second-line high-dose chemotherapy (HDCT) registered with the European Group for Blood and Marrow Transplantation (EBMT). Patients and methods: Between 1987 and 1999, 59 registered patients with retroperitoneal (n=37) and mediastinal (n=22) primary NSGCT, median age 28 years (range 18-60), were treated with second-line HDCT. All had received cisplatin-containing chemotherapy as first-line treatment. Results: Toxic death occurred in three cases (5%). With a median follow-up of 58 months (range 14-114), 18/59 patients (30%) continue to be disease-free. Of three patients who had a disease recurrence after HDCT, one patient achieved a disease-free status with further chemotherapy and surgery. In total, 19 patients (32%) are currently disease-free. Sixteen of 37 patients (43%) with retroperitoneal NSGCT, and three of 22 patients (14%) with mediastinal NSGCT are currently alive and disease-free. Conclusions: Second-line HDCT might represent a possible option for patients with retroperitoneal primary NSGCT. New salvage strategies are needed for patients with mediastinal NSGCT. © 2005 European Society for Medical Oncology.

Published
2005
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17. First-line high-dose chemotherapy for patients with poor prognosis extragonadal germ cell tumors: the experience of the European Bone Marrow Transplantation (EBMT) Solid Tumors Working Party

Author

Giovanni Rosti, U. De Giorgi, A Kulekci, Bruno Lioure, M Ballardini, Giorgio Papiani, K Kolbe, Hannes Wandt, Taner Demirer, and Serge Leyvraz

Subjects
Adult, Male, Oncology, medicine.medical_specialty, Extragonadal, Adolescent, Cyclophosphamide, medicine.medical_treatment, Antineoplastic Agents, Hematopoietic stem cell transplantation, chemistry.chemical_compound, Internal medicine, medicine, Humans, Registries, Etoposide, Retrospective Studies, Transplantation, Chemotherapy, business.industry, Remission Induction, Hematopoietic Stem Cell Transplantation, Hematology, Middle Aged, Prognosis, medicine.disease, Survival Analysis, Carboplatin, Surgery, Extragonadal Germ Cell Tumor, chemistry, Female, Risk Adjustment, Germinoma, Germ cell tumors, business, medicine.drug
Abstract

Extragonadal germ cell tumors are classified according to the staging system of the International Germ Cell Cancer Collaborative Group (IGCCCG). The 5-year overall and disease-free survival rates for poor prognosis patients are 41 and 48%, respectively after standard-dose chemotherapy. We report the experience of the EBMT Solid Tumours Working Party (STWP) with first-line HDCT with hematopoietic progenitor cell support (HPCS) in patients with poor prognosis extragonadal nonseminomatous germ cell tumor (NSGCT). Between 1990 and 2001, 22 extragonadal NSGCT patients (21 M, 1 F), median age 30 years (range 17-52) were treated with first-line HDCT with HPCS. Primary site was mediastinum in 11 patients, retroperitoneum in 10, and unknown in one. The Carbopec regimen, consisting of high doses of carboplatin, etoposide, and cyclophosphamide, was used in most cases (12 patients). No treatment-related deaths occurred. No patient developed myelodysplasia or a secondary leukemia. In total, 17 of 22 patients (77%) achieved complete remission. At a median follow-up of 50 months (range 26-132), 15 patients (68%) are alive disease-free. The survival rates of patients with poor prognosis extragonadal NSGCT treated with first-line HDCT in the EBMT STWP experience appear higher than that expected according to the IGCCCG classification.

Published
2004
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18. Exposure occurred, but Morbillivirus was not the likely cause of striped dolphin deaths in the Ligurian Sea during 2007

Author

G. Di Guardo, U. Proietto, C. E. Di Francesco, F. Marsilio, M. Baffoni, W. Mignone, P. Caroggio, F. Garibaldi, M. Ballardini, S. Kennedy, F. Forster, M. Podestà, E. Bozzetta, B. Iulini, C. Casalone, ZACCARONI, ANNALISA, SCARAVELLI, DINO, G. Di Guardo, U. Proietto, C. E. Di Francesco, F. Marsilio, M. Baffoni, A. Zaccaroni, D. Scaravelli, W. Mignone, P. Caroggio, F. Garibaldi, M. Ballardini, S. Kennedy, F. Forster, M. Podestà, E. Bozzetta, B. Iulini, and C. Casalone

Abstract

We report herein the results of post-mortem, parasitological, microbiological, histopathological, immunohistochemical (IHC), indirect immunofluorescence (IIF), biomolecular (RT-PCR) and serological investigations carried out on 8 (1 male calf, 1 subadult female, 5 adult females, 1 adult male) striped dolphins (S. coeruleoalba) found stranded from August to November 2007 on the Ligurian Sea coast of Italy. A (broncho-interstitial) pneumonia occurred in 6 animals, with numerous parasitic bodies in both pulmonary and extra-pulmonary locations. Histologically, a multifocal, subacute to chronic, nonpurulent meningo-encephalitis occurred in 1 adult male and 3 adult females, with more or less prominent perivascular cuffs of inflammatory mononuclear cells and peri-paravascular macrophage accumulations. A mild choroid plexus lymphocytic-plasmacytic infiltration was also present, along with moderate neuronal damage, although no viral inclusions were seen in any brain cell (nor in any other cell type). The blood sera from 4 dolphins (1 calf, 1 subadult, 2 adults) had anti-Morbillivirus neutralizing antibodies, with positive titres ranging from 1:10 to 1:40. Nevertheless, IHC, IIF and RT-PCR investigations gave negative results in all animals. On the basis of the above findings, we conclude that one or more factors other than Morbillivirus likely were the primary cause of these dolphin mortality episodes.

Published
2008

19. The Effects of digital implementation on ZePoC CoDec

Author

M. Ballardini, S. Santi, Riccardo Rovatti, Gianluca Setti, VARI, S. Santi, M. Ballardini, R. Rovatti, and G. Setti

Subjects
Digital electronics, Total harmonic distortion, Computer science, business.industry, Encoding (memory), Electronic engineering, Codec, business
Abstract

This paper investigates the intrinsic problems of a digital implementation of a ZePoC Codec. We review the basic steps of a ZePoC modulator, showing its intrinsically analog nature. Then we evaluate the loss of performance of a digitally implemented ZePoC modulator, in terms of harmonic distortion within a certain low-pass band. To do this, we developed a fully analytical method to evaluate the effects of nonlinearities over quasiperiodic signals. Finally, an application of the analytical method were shown in an example. The example results suggest that, though ZePoC modulator is theoretically optimal, its digital implementation would unavoidably lead to a high loss in its performance.

Published
2006
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20. High-dose epirubicin, preceded by dexrazoxane, given in combination with paclitaxel plus filgrastim provides an effective mobilizing regimen to support three courses of high-dose dense chemotherapy in patients with high-risk stage II-IIIA breast cancer

Author

M Baioni, Maurizio Marangolo, U. De Giorgi, M Ballardini, E Ferrari, Giovanni Rosti, M R Minzi, Alberto Zaniboni, and L Zornetta

Subjects
Oncology, Adult, medicine.medical_specialty, Neutropenia, Dose-dense chemotherapy, Filgrastim, Paclitaxel, medicine.medical_treatment, Breast Neoplasms, Cell Count, Breast cancer, Antigens, CD, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Granulocyte Colony-Stimulating Factor, medicine, Humans, Leukapheresis, skin and connective tissue diseases, Epirubicin, Transplantation, Chemotherapy, business.industry, Hematology, Middle Aged, medicine.disease, Hematopoietic Stem Cell Mobilization, Recombinant Proteins, Surgery, Granulocyte colony-stimulating factor, Regimen, Female, Dexrazoxane, business, Razoxane, medicine.drug
Abstract

We verified the possibility of collecting large amounts of peripheral blood stem cells (PBSCs) to support three courses of adjuvant high-dose dense chemotherapy (HDDC) with high-dose epirubicin, preceded by dexrazoxane, and high-dose paclitaxel, in patients with high-risk breast cancer (/=9 positive nodes). The mobilizing regimen consisted of high-dose epirubicin 150 mg/m(2), preceded by dexrazoxane 1000 mg/m(2) (day 1), given in combination with paclitaxel 175 mg/m(2) (day 2), plus filgrastim. Of the 25 patients enrolled, one went off study due to a severe hypersensitivity reaction to paclitaxel, another did not undergo leukapheresis due to fever persistent after hematological recovery, while in 23 patients an adequate number of PBSCs was collected by a single leukapheresis. The median number of CD34+, CD34+/CD33-, and CD34+/CD38- cells collected per patient was 17 x 10(6)/kg, 13.4 x 10(6)/kg, and 1.5 x 10(6)/kg, respectively. Neutropenia was the only grade 4 toxicity and lasted a median of 3 days. High-dose epirubicin, preceded by dexrazoxane for the first time used in mobilizing regimen, and paclitaxel plus filgrastim are effective in releasing large amounts of PBSCs, which can then be safely employed to support multiple courses of HDDC.

Published
2003

21. [Cohen syndrome. A new case and review of the literature]

Author

S, Calzolari, M, Ballardini, and P, De Marco

Subjects
Fingers, Male, Intellectual Disability, Humans, Abnormalities, Multiple, Obesity, Syndrome, Child
Abstract

We report the case of a 12-year-old child suffering from mild mental retardation, hypotonia, long hands with tapering fingers, microcephaly, truncal obesity, particular facial features. The association of these abnormalities has been known as Cohen Syndrome since 1973. Such a dysmorphic syndrome is usually inherited as an autosomal recessive trait whose gene has not been yet localized. There is no biological marker and the diagnosis is made only on a clinical basis. The diagnosis is quite difficult because of the intrafamiliar variation and the lack of a symptom present in 100% of the cases. From the analysis of the literature it proves that the more frequent symptoms are: mental retardation, open mouth, short philtrum, high palate, hypotonia. Because of the diagnostic difficulties it is possible that this syndrome was underestimate. Moreover, it is usually diagnosed too late, (mean age: 12,9). Therefore, we think necessary to consider the possibility of Cohen Syndrome in the case of every mental retardation of unknown cause.

Published
1995

23. Italian multicentric trial comparing chemotherapy with or without low-dose interleukin-2 (IL-2) in advanced non-small cell lung cancer: Results from a phase III randomized study

Author

A. Santo, Oscar Bertetto, Emanuele Naglieri, Ruggero Ridolfi, F. Recchia, M. Lopez, P. Lissoni, Laura Ridolfi, M. Ballardini, and Luca Fumagalli

Subjects
Interleukin 2, Oncology, Cancer Research, Chemotherapy, medicine.medical_specialty, business.industry, medicine.medical_treatment, Lymphocyte, Low dose, medicine.disease, law.invention, medicine.anatomical_structure, Randomized controlled trial, law, Internal medicine, Medicine, Non small cell, business, Lung cancer, Immunodeficiency, medicine.drug
Abstract

8019 Background: Non small cell lung cancer (NSCLC) is associated with an IL-2-dependent cell-mediated immunodeficiency, and lymphocyte count is considered an independent prognostic factor as it seems to correlate with overall survival. A phase III randomized Italian multicentric trial was conducted to evaluate the efficacy of subcutaneous low-dose IL-2 added to standard CT on overall survival (OS) in advanced NSCLC patients. Methods: Histologically/cytologically confirmed stage IIIb or IV non operable NSCLC patients with measurable disease, ECOG PS 0–2, age 18–70 years and adequate bone marrow, renal and liver function were eligible for the study. Randomization was stratified by center, ECOG PS, stage of disease and percentage of weight loss. All patients received gemcitabine (1000mg/m2) on days 1 and 8 + cisplatin (100mg/m2) on day 2 every 21 days for a maximum of 6 cycles (CT arm). In the CT+IL-2 arm, patients also received low-dose subcutaneous IL-2 3,000,000 IU/die on days 3–5; 9–11; 15–17. The study had 90% power to detect a 20% absolute increase in 1-year OS with 120 patients per arm. Results: From June 2000 to October 2004, 241 patients were randomized (arm A/B: 127/114). At a median follow up of 32 months, 1-year OS was 45% for the CT+IL-2 arm vs. 51% for the CT arm (p=0.456 logrank). Median progression-free survival was 6.6 months in the CT+IL-2 arm vs. 6.9 months in the CT arm (p=0.573, logrank). Conclusions: The study did not show any relevant difference in clinical outcome by the addition of IL-2 to CT. Safety and subgroup analyses are ongoing to verify the efficacy of IL-2 as a function of clinical and biological characteristics of patients and tumors. Future studies to investigate the role of T-regulators in chemoimmunotherapy strategies, unknown when the study was originally planned, could be conducted. No significant financial relationships to disclose.

Published
2009
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25. Exploring Cosmic Origins with CORE: The Instrument

Author

P. de Bernardis, P.A.R. Ade, J.J.A. Baselmans, E.S. Battistelli, A. Benoit, M. Bersanelli, A. Bideaud, M. Calvo, F.J. Casas, M.G. Castellano, A. Catalano, I. Charles, I. Colantoni, F. Columbro, A. Coppolecchia, M. Crook, G. D'Alessandro, M. De Petris, J. Delabrouille, S. Doyle, C. Franceschet, A. Gomez, J. Goupy, S. Hanany, M. Hills, L. Lamagna, J. Macias-Perez, B. Maffei, S. Martin, E. Martinez-Gonzalez, S. Masi, D. McCarthy, A. Mennella, A. Monfardini, F. Noviello, A. Paiella, F. Piacentini, M. Piat, G. Pisano, G. Signorelli, C.Y. Tan, A. Tartari, N. Trappe, S. Triqueneaux, C. Tucker, G. Vermeulen, K. Young, M. Zannoni, A. Achúcarro, R. Allison, E. Artall, M. Ashdown, M. Ballardini, A.J. Banday, R. Banerji, J. Bartlett, N. Bartolo, S. Basak, A. Bonaldi, M. Bonato, J. Borrill, F. Bouchet, F. Boulanger, T. Brinckmann, M. Bucher, C. Burigana, A. Buzzelli, Z.Y. Cai, C.S. Carvalho, A. Challinor, J. Chluba, S. Clesse, G. De Gasperis, G. De Zotti, E. Di Valentino, J.M. Diego, J. Errard, S. Feeney, R. Fernandez-Cobos, F. Finelli, F. Forastieri, S. Galli, R. Génova-Santos, M. Gerbino, J. González-Nuevo, S. Hagstotz, J. Greenslade, W. Handley, C. Hernández-Monteagudo, C. Hervias-Caimapo, E. Hivon, K. Kiiveri, T. Kisner, T. Kitching, M. Kunz, H. Kurki-Suonio, A. Lasenby, M. Lattanzi, J. Lesgourgues, A. Lewis, M. Liguori, V. Lindholm, G. Luzzi, C.J.A.P. Martins, S. Matarrese, A. Melchiorri, J.B. Melin, D. Molinari, P. Natoli, M. Negrello, A. Notari, D. Paoletti, G. Patanchon, L. Polastri, G. Polenta, A. Pollo, V. Poulin, M. Quartin, M. Remazeilles, M. Roman, J.A. Rubiño-Martín, L. Salvati, M. Tomasi, D. Tramonte, T. Trombetti, J. Väliviita, R. Van de Weyjgaert, B. van Tent, V. Vennin, P. Vielva, N. Vittorio, Institut Néel (NEEL), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Institut Nanosciences et Cryogénie (INAC), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut Lagrange de Paris, Sorbonne Université (SU), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Département de Physique des Particules (ex SPP) (DPP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Annecy-le-Vieux de Physique Théorique (LAPTH), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Théorique d'Orsay [Orsay] (LPT), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), CORE, Hélium : du fondamental aux applications (NEEL - HELFA), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Cryogénie (NEEL - Cryo), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Laboratoire des Cryoréfrigérateurs et Cryogénie Spatiale (LCCS), Service des Basses Températures (SBT ), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Département de Physique des Particules (ex SPP) (DPhP), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Helsinki Institute of Physics, Department of Physics, Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Sorbonne Universités, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), de Bernardis, P, Ade, P, Baselmans, J, Battistelli, E, Benoit, A, Bersanelli, M, Bideaud, A, Calvo, M, Casas, F, Castellano, M, Catalano, A, Charles, I, Colantoni, I, Columbro, F, Coppolecchia, A, Crook, M, D'Alessandro, G, Petris, M, Delabrouille, J, Doyle, S, Franceschet, C, Gomez, A, Goupy, J, Hanany, S, Hills, M, Lamagna, L, Macias-Perez, J, Maffei, B, Martin, S, Martinez-Gonzalez, E, Masi, S, Mccarthy, D, Mennella, A, Monfardini, A, Noviello, F, Paiella, A, Piacentini, F, Piat, M, Pisano, G, Signorelli, G, Tan, C, Tartari, A, Trappe, N, Triqueneaux, S, Tucker, C, Vermeulen, G, Young, K, Zannoni, M, Achúcarro, A, Allison, R, Artall, E, Ashdown, M, Ballardini, M, Banday, A, Banerji, R, Bartlett, J, Bartolo, N, Basak, S, Bonaldi, A, Bonato, M, Borrill, J, Bouchet, F, Boulanger, F, Brinckmann, T, Bucher, M, Burigana, C, Buzzelli, A, Cai, Z, Carvalho, C, Challinor, A, Chluba, J, Clesse, S, Gasperis, G, Zotti, G, Valentino, E, Diego, J, Errard, J, Feeney, S, Fernandez-Cobos, R, Finelli, F, Forastieri, F, Galli, S, Génova-Santos, R, Gerbino, M, González-Nuevo, J, Hagstotz, S, Greenslade, J, Handley, W, Hernández-Monteagudo, C, Hervias-Caimapo, C, Hivon, E, Kiiveri, K, Kisner, T, Kitching, T, Kunz, M, Kurki-Suonio, H, Lasenby, A, Lattanzi, M, Lesgourgues, J, Lewis, A, Liguori, M, Lindholm, V, Luzzi, G, Martins, C, Matarrese, S, Melchiorri, A, Melin, J, Molinari, D, Natoli, P, Negrello, M, Notari, A, Paoletti, D, Patanchon, G, Polastri, L, Polenta, G, Pollo, A, Poulin, V, Quartin, M, Remazeilles, M, Roman, M, Rubiño-Martín, J, Salvati, L, Tomasi, M, Tramonte, D, Trombetti, T, Väliviita, J, de Weyjgaert, R, Tent, B, Vennin, V, Vielva, P, Vittorio, N, Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Institut Néel ( NEEL ), Université Grenoble Alpes [Saint Martin d'Hères]-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physique Subatomique et de Cosmologie ( LPSC ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Institut Nanosciences et Cryogénie ( INAC ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Grenoble Alpes ( UGA ), AstroParticule et Cosmologie ( APC - UMR 7164 ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Institut d'astrophysique spatiale ( IAS ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de recherche en astrophysique et planétologie ( IRAP ), Université Paul Sabatier - Toulouse 3 ( UPS ) -Observatoire Midi-Pyrénées ( OMP ) -Centre National de la Recherche Scientifique ( CNRS ), Institut d'Astrophysique de Paris ( IAP ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physique Nucléaire et de Hautes Énergies ( LPNHE ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Département de Physique des Particules (ex SPP) ( DPP ), Institut de Recherches sur les lois Fondamentales de l'Univers ( IRFU ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Laboratoire d'Annecy-le-Vieux de Physique Théorique ( LAPTH ), Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physique Théorique d'Orsay [Orsay] ( LPT ), and Université Paris-Sud - Paris 11 ( UP11 ) -Centre National de la Recherche Scientifique ( CNRS )

Subjects
[ PHYS.ASTR ] Physics [physics]/Astrophysics [astro-ph], Kinetic inductance detectors, Cosmic microwave background, KINETIC INDUCTANCE DETECTORS, cosmic background radiation: polarization, DUAL-REFLECTOR ANTENNAS, 01 natural sciences, 7. Clean energy, BAND, law.invention, law, CMBR experiments, physics.ins-det, [ PHYS.PHYS.PHYS-INS-DET ] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010303 astronomy & astrophysics, QC, QB, CALIBRATION, Physics, COSMIC cancer database, COMBINATIONS, Astrophysics::Instrumentation and Methods for Astrophysics, Instrumentation and Detectors (physics.ins-det), Polarization (waves), PLANCK, Cardinal point, experimental equipment, astro-ph.CO, CMBR detectors, CMBR experiment, astro-ph.IM, physics - instrumentation and detectors, Astrophysics - Instrumentation and Methods for Astrophysics, CMBR polarization, ination, Astronomy and Astrophysics, CMBR detector, Astrophysics - Cosmology and Nongalactic Astrophysics, PRESCRIBED GEOMETRIC PARAMETERS, CMBR polarisation, Cosmic Vision, Cosmology and Nongalactic Astrophysics (astro-ph.CO), kinetic, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, NO, Telescope, FIS/05 - ASTRONOMIA E ASTROFISICA, Optics, Settore FIS/05 - Astronomia e Astrofisica, 0103 physical sciences, PRE-LAUNCH STATUS, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], inflation, Instrumentation and Methods for Astrophysics (astro-ph.IM), Astrophysics::Galaxy Astrophysics, beam: polarization, detector, 010308 nuclear & particles physics, business.industry, beam: width, Polarimeter, PERFORMANCE, WAVELENGTHS, 115 Astronomy, Space science, sensitivity, CMBR detectors, CMBR experiments, CMBR polarisation, inflation, business, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract

PdB acknowledges support from University of Rome La Sapienza (project “Cosmologia di Precisione 2015”) and from the Italian Space Agency (Agreement 2016-019-H.0 “Kinetic Inductance Detectors for Space”). CJM is supported by an FCT Research Professorship, contract reference IF/00064/2012, funded by FCT/MCTES (Portugal) and POPH/FSE (EC). C.H.-M. acknowledges the financial support of the Spanish Ministry of Economy and Competitiveness via I+D project AYA-2015-66211-C2-2-P. GDZ acknowledges the financial support of ASI/INAF agreement n. 2014-024-R.1. J.G.N. acknowledges financial support from the Spanish MINECO for a “Ramon y Cajal” fellowship (RYC-2013-13256) and the I+D 2015 project AYA2015-65887-P (MINECO/FEDER). F.J.C., E.M.-G. and P.V. acknowledge support from the Spanish Ministerio de Econom´ıa y Competitividad project ESP2015-70646- C2-1-R co-financed with EU FEDER funds., De Bernardis, P., Ade, P.A.R., Baselmans, J.J.A., Battistelli, E.S., Benoit, A., Bersanelli, M., Bideaud, A., Calvo, M., Casas, F.J., Castellano, M.G., Catalano, A., Charles, I., Colantoni, I., Columbro, F., Coppolecchia, A., Crook, M., D'Alessandro, G., Petris, M.D., Delabrouille, J., Doyle, S., Franceschet, C., Gomez, A., Goupy, J., Hanany, S., Hills, M., Lamagna, L., Macias-Perez, J., Maffei, B., Martin, S., Martinez-Gonzalez, E., Masi, S., McCarthy, D., Mennella, A., Monfardini, A., Noviello, F., Paiella, A., Piacentini, F., Piat, M., Pisano, G., Signorelli, G., Tan, C.Y., Tartari, A., Trappe, N., Triqueneaux, S., Tucker, C., Vermeulen, G., Young, K., Zannoni, M., Achúcarro, A., Allison, R., Artall, E., Ashdown, M., Ballardini, M., Banday, A.J., Banerji, R., Bartlett, J., Bartolo, N., Basak, S., Bonaldi, A., Bonato, M., Borrill, J., Bouchet, F., Boulanger, F., Brinckmann, T., Bucher, M., Burigana, C., Buzzelli, A., Cai, Z.Y., Carvalho, C.S., Challinor, A., Chluba, J., Clesse, S., Gasperis, G.D., Zotti, G.D., Valentino, E.D., Diego, J.M., Errard, J., Feeney, S., Fernandez-Cobos, R., Finelli, F., Forastieri, F., Galli, S., Génova-Santos, R., Gerbino, M., González-Nuevo, J., Hagstotz, S., Greenslade, J., Handley, W., Hernández-Monteagudo, C., Hervias-Caimapo, C., Hivon, E., Kiiveri, K., Kisner, T., Kitching, T., Kunz, M., Kurki-Suonio, H., Lasenby, A., Lattanzi, M., Lesgourgues, J., Lewis, A., Liguori, M., Lindholm, V., Luzzi, G., Martins, C.J.A.P., Matarrese, S., Melchiorri, A., Melin, J.B., Molinari, D., Natoli, P., Negrello, M., Notari, A., Paoletti, D., Patanchon, G., Polastri, L., Polenta, G., Pollo, A., Poulin, V., Quartin, M., Remazeilles, M., Roman, M., Rubiño-Martín, J.A., Salvati, L., Tomasi, M., Tramonte, D., Trombetti, T., Väliviita, J., De Weyjgaert, R.V., Tent, B.V., Vennin, V., Vielva, P., Vittorio, N.

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26. Euclid preparation : XXIII. Derivation of galaxy physical properties with deep machine learning using mock fluxes and H-band images

Author

Collaboration, Euclid, Bisigello, L, Conselice, C J, Baes, M, Bolzonella, M, Brescia, M, Cavuoti, S, Cucciati, O, Humphrey, A, Hunt, L K, Maraston, C, Pozzetti, L, Tortora, C, van Mierlo, S E, Aghanim, N, Auricchio, N, Baldi, M, Bender, R, Bodendorf, C, Bonino, D, Branchini, E, Brinchmann, J, Camera, S, Capobianco, V, Carbone, C, Carretero, J, Castander, F J, Castellano, M, Cimatti, A, Congedo, G, Conversi, L, Copin, Y, Corcione, L, Courbin, F, Cropper, M, Da Silva, A, Degaudenzi, H, Douspis, M, Dubath, F, Duncan, C A J, Dupac, X, Dusini, S, Farrens, S, Ferriol, S, Frailis, M, Franceschi, E, Franzetti, P, Fumana, M, Garilli, B, Gillard, W, Gillis, B, Giocoli, C, Grazian, A, Grupp, F, Guzzo, L, Haugan, S V H, Holmes, W, Hormuth, F, Hornstrup, A, Jahnke, K, Kümmel, M, Kermiche, S, Kiessling, A, Kilbinger, M, Kohley, R, Kunz, M, Kurki-Suonio, H, Ligori, S, Lilje, P B, Lloro, I, Maiorano, E, Mansutti, O, Marggraf, O, Markovic, K, Marulli, F, Massey, R, Maurogordato, S, Medinaceli, E, Meneghetti, M, Merlin, E, Meylan, G, Moresco, M, Moscardini, L, Munari, E, Niemi, S M, Padilla, C, Paltani, S, Pasian, F, Pedersen, K, Pettorino, V, Polenta, G, Poncet, M, Popa, L, Raison, F, Renzi, A, Rhodes, J, Riccio, G, Rix, H -W, Romelli, E, Roncarelli, M, Rosset, C, Rossetti, E, Saglia, R, Sapone, D, Sartoris, B, Schneider, P, Scodeggio, M, Secroun, A, Seidel, G, Sirignano, C, Sirri, G, Stanco, L, Tallada-Crespí, P, Tavagnacco, D, Taylor, A N, Tereno, I, Toledo-Moreo, R, Torradeflot, F, Tutusaus, I, Valentijn, E A, Valenziano, L, Vassallo, T, Wang, Y, Zacchei, A, Zamorani, G, Zoubian, J, Andreon, S, Bardelli, S, Boucaud, A, Colodro-Conde, C, Ferdinando, D Di, Graciá-Carpio, J, Lindholm, V, Maino, D, Mei, S, Scottez, V, Sureau, F, Tenti, M, Zucca, E, Borlaff, A S, Ballardini, M, Biviano, A, Bozzo, E, Burigana, C, Cabanac, R, Cappi, A, Carvalho, C S, Casas, S, Castignani, G, Cooray, A, Coupon, J, Courtois, H M, Cuby, J, Davini, S, De Lucia, G, Desprez, G, Dole, H, Escartin, J A, Escoffier, S, Farina, M, Fotopoulou, S, Ganga, K, Garcia-Bellido, J, George, K, Giacomini, F, Gozaliasl, G, Hildebrandt, H, Hook, I, Huertas-Company, M, Kansal, V, Keihanen, E, Kirkpatrick, C C, Loureiro, A, Macías-Pérez, J F, Magliocchetti, M, Mainetti, G, Marcin, S, Martinelli, M, Martinet, N, Metcalf, R B, Monaco, P, Morgante, G, Nadathur, S, Nucita, A A, Patrizii, L, Peel, A, Potter, D, Pourtsidou, A, Pöntinen, M, Reimberg, P, Sánchez, A G, Sakr, Z, Schirmer, M, Sefusatti, E, Sereno, M, Stadel, J, Teyssier, R, Valieri, C, Valiviita, J, Viel, M, Astronomy, Euclid Collaboration, L. Bisigello, C. J. Conselice, M. Bae, M. Bolzonella, M. Brescia, S. Cavuoti, O. Cucciati, A. Humphrey, L. K. Hunt, C. Maraston, L. Pozzetti, C. Tortora, S. E. van Mierlo, N. Aghanim, N. Auricchio, M. Baldi, R. Bender, C. Bodendorf, D. Bonino, E. Branchini, J. Brinchmann, S. Camera, V. Capobianco, C. Carbone, J. Carretero, F. J. Castander, M. Castellano, A. Cimatti, G. Congedo, L. Conversi, Y. Copin, L. Corcione, F. Courbin, M. Cropper, A. Da Silva, H. Degaudenzi, M. Douspi, F. Dubath, C. A. J. Duncan, X. Dupac, S. Dusini, S. Farren, S. Ferriol, M. Fraili, E. Franceschi, P. Franzetti, M. Fumana, B. Garilli, W. Gillard, B. Gilli, C. Giocoli, A. Grazian, F. Grupp, L. Guzzo, S. V. H. Haugan, W. Holme, F. Hormuth, A. Hornstrup, K. Jahnke, M. Kümmel, S. Kermiche, A. Kiessling, M. Kilbinger, R. Kohley, M. Kunz, H. Kurki-Suonio, S. Ligori, P. B. Lilje, I. Lloro, E. Maiorano, O. Mansutti, O. Marggraf, K. Markovic, F. Marulli, R. Massey, S. Maurogordato, E. Medinaceli, M. Meneghetti, E. Merlin, G. Meylan, M. Moresco, L. Moscardini, E. Munari, S. M. Niemi, C. Padilla, S. Paltani, F. Pasian, K. Pedersen, V. Pettorino, G. Polenta, M. Poncet, L. Popa, F. Raison, A. Renzi, J. Rhode, G. Riccio, H. -W. Rix, E. Romelli, M. Roncarelli, C. Rosset, E. Rossetti, R. Saglia, D. Sapone, B. Sartori, P. Schneider, M. Scodeggio, A. Secroun, G. Seidel, C. Sirignano, G. Sirri, L. Stanco, P. Tallada-Crespí, D. Tavagnacco, A. N. Taylor, I. Tereno, R. Toledo-Moreo, F. Torradeflot, I. Tutusau, E. A. Valentijn, L. Valenziano, T. Vassallo, Y. Wang, A. Zacchei, G. Zamorani, J. Zoubian, S. Andreon, S. Bardelli A. Boucaud, C. Colodro-Conde, D. Di Ferdinando, J. Graciá-Carpio, V. Lindholm, D. Maino, S. Mei, V. Scottez, F. Sureau, M. Tenti, E. Zucca, A. S. Borlaff, M. Ballardini, A. Biviano, E. Bozzo, C. Burigana, R. Cabanac, A. Cappi, C. S. Carvalho, S. Casa, G. Castignani, A. Cooray, J. Coupon, H. M. Courtoi, J. Cuby, S. Davini, G. De Lucia, G. Desprez, H. Dole, J. A. Escartin, S. Escoffier, M. Farina, S. Fotopoulou, K. Ganga, J. Garcia-Bellido, K. George, F. Giacomini, G. Gozaliasl, H. Hildebrandt, I. Hook, M. Huertas-Company, V. Kansal, E. Keihanen, C. C. Kirkpatrick, A. Loureiro, J. F. Macías-Pérez, M. Magliocchetti, G. Mainetti, S. Marcin, M. Martinelli, N. Martinet, R. B. Metcalf, P. Monaco, G. Morgante, S. Nadathur, A. A. Nucita, L. Patrizii, A. Peel, D. Potter, A. Pourtsidou, M. Pöntinen, P. Reimberg, A. G. Sánchez, Z. Sakr, M. Schirmer, E. Sefusatti, M. Sereno, J. Stadel, R. Teyssier, C. Valieri, J. Valiviita, M. Viel, Bisigello, L., Conselice, C. J., Baes, M., Bolzonella, M., Brescia, M., Cavuoti, S., Cucciati, O., Humphrey, A., Hunt, L. K., Maraston11, C., Pozzetti, L., Tortora, C., van Mierlo, S. E., Aghanim, N., Auricchio, N., Baldi, M., Bender, R., Bodendorf, C., Bonino, D., Branchini, E., Brinchmann, J., Camera, S., Capobianco, V., Carbone, C., Carretero, J., Castander, F. J., Castellano, M., Cimatti, A., Congedo, G., Conversi, L., Copin, Y., Corcione, L., Courbin, F., Cropper, M., Da Silva, A., Degaudenzi, H., Douspis, M., Dubath, F., Duncan, C. A. J., Dupac, X., Dusini, S., Farrens, S., Ferriol, S., Frailis, M., Franceschi, E., Franzetti, P., Fumana, M., Garilli, B., Gillard, W., Gillis, B., Giocoli, C., Grazian, A., Grupp, F., Guzzo, L., Haugan, S. V. H., Holmes, W., Hormuth, F., Hornstrup, A., Jahnke, K., Kümmel, M., Kermiche, S., Kiessling, A., Kilbinger, M., Kohley, R., Kunz, M., Kurki-Suonio, H., Ligori, S., Lilje, P. B., Lloro, I., Maiorano, E., Mansutti, O., Marggraf, O., Markovic, K., Marulli, F., Massey, R., Maurogordato, S., Medinaceli, E., Meneghetti, M., Merlin, E., Meylan, G., Moresco, M., Moscardini, L., Munari, E., Niemi, S. M., Padilla, C., Paltani, S., Pasian, F., Pedersen, K., Pettorino, V., Polenta, G., Poncet, M., Popa, L., Raison, F., Renzi, A., Rhodes, J., Riccio, G., Rix, H. -W., Romelli, E., Roncarelli, M., Rosset, C., Rossetti, E., Saglia, R., Sapone, D., Sartoris, B., Schneider, P., Scodeggio, M., Secroun, A., Seidel, G., Sirignano, C., Sirri, G., Stanco, L., Tallada-Crespí, P., Tavagnacco, D., Taylor, A. N., Tereno, I., Toledo-Moreo, R., Torradeflot, F., Tutusaus, I., Valentijn, E. A., Valenziano, L., Vassallo, T., Wang, Y., Zacchei, A., Zamorani, G., Zoubian, J., Andreon, S., Boucaud, S. Bardelli A., Colodro-Conde, C., Di Ferdinando, D., Graciá-Carpio, J., Lindholm, V., Maino, D., Mei, S., Scottez, V., Sureau, F., Tenti, M., Zucca, E., Borlaff, A. S., Ballardini, M., Biviano, A., Bozzo, E., Burigana, C., Cabanac, R., Cappi, A., Carvalho, C. S., Casas, S., Castignani, G., Cooray, A., Coupon, J., Courtois, H. M., Cuby, J., Davini, S., De Lucia, G., Desprez, G., Dole, H., Escartin, J. A., Escoffier, S., Farina, M., Fotopoulou, S., Ganga, K., Garcia-Bellido, J., George, K., Giacomini, F., Gozaliasl, G., Hildebrandt, H., Hook, I., Huertas-Company, M., Kansal, V., Keihanen, E., Kirkpatrick, C. C., Loureiro, A., Macías-Pérez, J. F., Magliocchetti, M., Mainetti, G., Marcin, S., Martinelli, M., Martinet, N., Metcalf, R. B., Monaco, P., Morgante, G., Nadathur, S., Nucita, A. A., Patrizii, L., Peel, A., Potter, D., Pourtsidou, A., Pöntinen, M., Reimberg, P., Sánchez, A. G., Sakr, Z., Schirmer, M., Sefusatti, E., Sereno, M., Stadel, J., Teyssier, R., Valieri, C., Valiviita111, J., Viel, M., Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Observatoire de la Côte d'Azur (OCA), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique (LERMA), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
FOS: Physical sciences, Euclid, Astronomy and Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, galaxies: general, galaxies: general, galaxies: photometry, galaxies: star formation, galaxies: evolution, Astrophysics - Astrophysics of Galaxies, Cosmology, galaxies: photometry, Physics and Astronomy, [SDU]Sciences of the Universe [physics], Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), galaxies: star formation, photometry [galaxies], star formation [galaxies], galaxies: evolution, Astrophysics::Galaxy Astrophysics, evolution [galaxies], general [galaxies]
Abstract

Next generation telescopes, like Euclid, Rubin/LSST, and Roman, will open new windows on the Universe, allowing us to infer physical properties for tens of millions of galaxies. Machine learning methods are increasingly becoming the most efficient tools to handle this enormous amount of data, because they are often faster and more accurate than traditional methods. We investigate how well redshifts, stellar masses, and star-formation rates (SFR) can be measured with deep learning algorithms for observed galaxies within data mimicking the Euclid and Rubin/LSST surveys. We find that Deep Learning Neural Networks and Convolutional Neutral Networks (CNN), which are dependent on the parameter space of the training sample, perform well in measuring the properties of these galaxies and have a better accuracy than methods based on spectral energy distribution fitting. CNNs allow the processing of multi-band magnitudes together with $H_{\scriptscriptstyle\rm E}$-band images. We find that the estimates of stellar masses improve with the use of an image, but those of redshift and SFR do not. Our best results are deriving i) the redshift within a normalised error of less than 0.15 for 99.9$\%$ of the galaxies with S/N>3 in the $H_{\scriptscriptstyle\rm E}$-band; ii) the stellar mass within a factor of two ($\sim0.3 \rm dex$) for 99.5$\%$ of the considered galaxies; iii) the SFR within a factor of two ($\sim0.3 \rm dex$) for $\sim$70$\%$ of the sample. We discuss the implications of our work for application to surveys as well as how measurements of these galaxy parameters can be improved with deep learning., accepted for publication in MNRAS, 21 pages, 22 figures, 6 tables

Published
2023
Full Text
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27. Euclid preparation : XX. The Complete Calibration of the Color-Redshift Relation survey: LBT observations and data release

Author

Euclid Collaboration, Saglia, R., De Nicola, S., Fabricius, M., Guglielmo, V., Snigula, J., Zöller, R., Bender, R., Heidt, J., Masters, D., Stern, D., Paltani, S., Amara, A., Auricchio, N., Baldi, M., Bodendorf, C., Bonino, D., Branchini, E., Brescia, M., Brinchmann, J., Camera, S., Capobianco, V., Carbone, C., Carretero, J., Castellano, M., Cavuoti, S., Cledassou, R., Congedo, G., Conselice, C. J., Conversi, L., Copin, Y., Corcione, L., Courbin, F., Cropper, M., Da Silva, A., Degaudenzi, H., Douspis, M., Dubath, F., Duncan, C. A. J., Dupac, X., Dusini, S., Farrens, S., Frailis, M., Franceschi, E., Galeotta, S., Garilli, B., Gillard, W., Gillis, B., Giocoli, C., Grazian, A., Grupp, F., Haugan, S. V. H., Hoekstra, H., Holmes, W., Hormuth, F., Hornstrup, A., Jahnke, K., Kümmel, M., Kermiche, S., Kiessling, A., Kunz, M., Kurki-Suonio, H., Laureijs, R., Ligori, S., Lilje, P. B., Lloro, I., Maiorano, E., Marggraf, O., Markovic, K., Marulli, F., Massey, R., McCracken, H. J., Melchior, M., Meylan, G., Moresco, M., Moscardini, L., Munari, E., Niemi, S. M., Padilla, C., Pasian, F., Pedersen, K., Percival, W. J., Pettorino, V., Pires, S., Poncet, M., Popa, L., Pozzetti, L., Raison, F., Renzi, A., Rhodes, J., Riccio, G., Romelli, E., Rossetti, E., Sapone, D., Sartoris, B., Schneider, P., Secroun, A., Seidel, G., Sirignano, C., Sirri, G., Stanco, L., Tallada-Crespí, P., Tavagnacco, D., Taylor, A. N., Tereno, I., Toledo-Moreo, R., Torradeflot, F., Tutusaus, I., Valentijn, E. A., Valenziano, L., Vassallo, T., Wang, Y., Zacchei, A., Zamorani, G., Zoubian, J., Andreon, S., Bardelli, S., Graciá-Carpio, J., Maino, D., Mauri, N., Tramacere, A., Zucca, E., Ayllon, A. Alvarez, Aussel, H., Baccigalupi, C., Balaguera-Antolínez, A., Ballardini, M., Biviano, A., Bolzonella, M., Bozzo, E., Burigana, C., Cabanac, R., Cappi, A., Carvalho, C. S., Casas, S., Castignani, G., Cooray, A., Coupon, J., Courtois, H. M., Davini, S., Desprez, G., Dole, H., Escartin, J. A., Escoffier, S., Farina, M., Fotopoulou, S., Ganga, K., Garcia-Bellido, J., George, K., Giacomini, F., Gozaliasl, G., Hildebrandt, H., Hook, I., Ilbert, O., Kansal, V., Kashlinsky, A., Keihanen, E., Kirkpatrick, C. C., Loureiro, A., Macías-Pérez, J., Magliocchetti, M., Mainetti, G., Maoli, R., Martinelli, M., Martinet, N., Metcalf, R. B., Morgante, G., Nadathur, S., Nucita, A. A., Patrizii, L., Popa, V., Porciani, C., Potter, D., Pourtsidou, A., Reimberg, P., Sánchez, A. G., Sakr, Z., Schirmer, M., Sefusatti, E., Sereno, M., Stadel, J., Teyssier, R., Valieri, C., Valiviita, J., Veropalumbo, A., Viel, M., Department of Physics, Research Program in Systems Oncology, Helsinki Institute of Physics, Saglia, R., De Nicola, S., Fabricius, M., Guglielmo, V., Snigula, J., Z??ller, R., Bender, R., Heidt, J., Masters, D., Stern, D., Paltani, S., Amara, A., Auricchio, N., Baldi, M., Bodendorf, C., Bonino, D., Branchini, E., Brescia, M., Brinchmann, J., Camera, S., Capobianco, V., Carbone, C., Carretero, J., Castellano, M., Cavuoti, S., Cledassou, R., Congedo, G., Conselice, C. J., Conversi, L., Copin, Y., Corcione, L., Courbin, F., Cropper, M., Da Silva, A., Degaudenzi, H., Douspis, M., Dubath, F., Duncan, C. A. J., Dupac, X., Dusini, S., Farrens, S., Frailis, M., Franceschi, E., Galeotta, S., Garilli, B., Gillard, W., Gillis, B., Giocoli, C., Grazian, A., Grupp, F., Haugan, S. V. H., Hoekstra, H., Holmes, W., Hormuth, F., Hornstrup, A., Jahnke, K., K??mmel, M., Kermiche, S., Kiessling, A., Kunz, M., Kurki-Suonio, H., Laureijs, R., Ligori, S., Lilje, P. B., Lloro, I., Maiorano, E., Marggraf, O., Markovic, K., Marulli, F., Massey, R., Mccracken, H. J., Melchior, M., Meylan, G., Moresco, M., Moscardini, L., Munari, E., Niemi, S. M., Padilla, C., Pasian, F., Pedersen, K., Percival, W. J., Pettorino, V., Pires, S., Poncet, M., Popa, L., Pozzetti, L., Raison, F., Renzi, A., Rhodes, J., Riccio, G., Romelli, E., Rossetti, E., Sapone, D., Sartoris, B., Schneider, P., Secroun, A., Seidel, G., Sirignano, C., Sirri, G., Stanco, L., Tallada-Cresp??, P., Tavagnacco, D., Taylor, A. N., Tereno, I., Toledo-Moreo, R., Torradeflot, F., Tutusaus, I., Valentijn, E. A., Valenziano, L., Vassallo, T., Wang, Y., Zacchei, A., Zamorani, G., Zoubian, J., Andreon, S., Bardelli, S., Graci??-Carpio, J., Maino, D., Mauri, N., Tramacere, A., Zucca, E., Alvarez Ayllon, A., Aussel, H., Baccigalupi, C., Balaguera-Antol??nez, A., Ballardini, M., Biviano, A., Bolzonella, M., Bozzo, E., Burigana, C., Cabanac, R., Cappi, A., Carvalho, C. S., Casas, S., Castignani, G., Cooray, A., Coupon, J., Courtois, H. M., Davini, S., Desprez, G., Dole, H., Escartin, J. A., Escoffier, S., Farina, M., Fotopoulou, S., Ganga, K., Garcia-Bellido, J., George, K., Giacomini, F., Gozaliasl, G., Hildebrandt, H., Hook, I., Ilbert, O., Kansal, V., Kashlinsky, A., Keihanen, E., Kirkpatrick, C. C., Loureiro, A., Mac??as-P??rez, J., Magliocchetti, M., Mainetti, G., Maoli, R., Martinelli, M., Martinet, N., Metcalf, R. B., Morgante, G., Nadathur, S., Nucita, A. A., Patrizii, L., Popa, V., Porciani, C., Potter, D., Pourtsidou, A., Reimberg, P., S??nchez, A. G., Sakr, Z., Schirmer, M., Sefusatti, E., Sereno, M., Stadel, J., Teyssier, R., Valieri, C., Valiviita, J., Veropalumbo, A., Viel, M., Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Euclid, Intelligent Systems, Astronomy, R. Saglia, S. De Nicola, M. Fabriciu, V. Guglielmo, J. Snigula, R. Zöller, R. Bender, J. Heidt, D. Master, D. Stern, S. Paltani, A. Amara, N. Auricchio, M. Baldi, C. Bodendorf, D. Bonino, E. Branchini, M. Brescia, J. Brinchmann, S. Camera, V. Capobianco, C. Carbone, J. Carretero, M. Castellano, S. Cavuoti, R. Cledassou, G. Congedo, C. J. Conselice, L. Conversi, Y. Copin, L. Corcione, F. Courbin, M. Cropper, A. Da Silva, H. Degaudenzi, M. Douspi, F. Dubath, C. A. J. Duncan, X. Dupac, S. Dusini, S. Farren, M. Fraili, E. Franceschi, S. Galeotta, B. Garilli, W. Gillard, B. Gilli, C. Giocoli, A. Grazian, F. Grupp, S. V. H. Haugan, H. Hoekstra, W. Holme, F. Hormuth, A. Hornstrup, K. Jahnke, M. Kümmel, S. Kermiche, A. Kiessling, M. Kunz, H. Kurki-Suonio, R. Laureij, S. Ligori, P. B. Lilje, I. Lloro, E. Maiorano, O. Marggraf, K. Markovic, F. Marulli, R. Massey, H. J. McCracken, M. Melchior, G. Meylan, M. Moresco, L. Moscardini, E. Munari, S. M. Niemi, C. Padilla, F. Pasian, K. Pedersen, W. J. Percival, V. Pettorino, S. Pire, M. Poncet, L. Popa, L. Pozzetti, F. Raison, A. Renzi, J. Rhode, G. Riccio, E. Romelli, E. Rossetti, D. Sapone, B. Sartori, P. Schneider, A. Secroun, G. Seidel, C. Sirignano, G. Sirri, L. Stanco, P. Tallada-Crespí, D. Tavagnacco, A. N. Taylor, I. Tereno, R. Toledo-Moreo, F. Torradeflot, I. Tutusau, E. A. Valentijn, L. Valenziano, T. Vassallo, Y. Wang, A. Zacchei, G. Zamorani, J. Zoubian, S. Andreon, S. Bardelli, J. Graciá-Carpio, D. Maino, N. Mauri, A. Tramacere, E. Zucca, A. Alvarez Ayllon, H. Aussel, C. Baccigalupi, A. Balaguera-Antolínez, M. Ballardini, A. Biviano, M. Bolzonella, E. Bozzo, C. Burigana, R. Cabanac, A. Cappi, C. S. Carvalho, S. Casa, G. Castignani, A. Cooray, J. Coupon, H. M. Courtoi, S. Davini, G. Desprez, H. Dole, J. A. Escartin, S. Escoffier, M. Farina, S. Fotopoulou, K. Ganga, J. Garcia-Bellido, K. George, F. Giacomini, G. Gozaliasl, H. Hildebrandt, I. Hook, O. Ilbert, V. Kansal, A. Kashlinsky, E. Keihanen, C. C. Kirkpatrick, A. Loureiro, J. Macías-Pérez, M. Magliocchetti, G. Mainetti, R. Maoli, M. Martinelli, N. Martinet, R. B. Metcalf, G. Morgante, S. Nadathur, A. A. Nucita, L. Patrizii, V. Popa, C. Porciani, D. Potter, A. Pourtsidou, P. Reimberg, A. G. Sánchez, Z. Sakr, M. Schirmer, E. Sefusatti, M. Sereno, J. Stadel, R. Teyssier, C. Valieri, J. Valiviita, A. Veropalumbo, M. Viel, Zöller, R., Kümmel, M., Tallada-Crespí, P., Graciá-Carpio, J., Balaguera-Antolínez, A., Macías-Pérez, J., and Sánchez, A. G.

Subjects
Cosmology and Nongalactic Astrophysics (astro-ph.CO), catalogs, Galaxies: distances and redshifts, surveys, Astrophysics - cosmology and nongalactic astrophysics, Astrophysics::Instrumentation and Methods for Astrophysics, Euclid, FOS: Physical sciences, Galaxies - distances and redshifts, Astronomy and Astrophysics, cosmos, Astrophysics::Cosmology and Extragalactic Astrophysics, Surveys, 115 Astronomy, Space science, Cosmology, deep imaging survey, Space and Planetary Science, distances and redshifts, catalogs, surveys [galaxies], distances and redshifts [Galaxies], galaxies: distances and redshifts, Catalogs, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics::Galaxy Astrophysics
Abstract

The Complete Calibration of the Color-Redshift Relation survey (C3R2) is a spectroscopic programme designed to empirically calibrate the galaxy color-redshift relation to the Euclid depth (I_E=24.5), a key ingredient for the success of Stage IV dark energy projects based on weak lensing cosmology. A spectroscopic calibration sample as representative as possible of the galaxies in the Euclid weak lensing sample is being collected, selecting galaxies from a self-organizing map (SOM) representation of the galaxy color space. Here, we present the results of a near-infrared H- and K-bands spectroscopic campaign carried out using the LUCI instruments at the LBT. For a total of 251 galaxies, we present new highly-reliable redshifts in the 1.3, A&A language edited version

Published
2022
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28. Planck 2018 results

Author

Antony Lewis, X. Dupac, James R. Fergusson, François R. Bouchet, Diego Molinari, E. Martínez-González, Jean-François Cardoso, L. Salvati, Jörg P. Rachen, Krzysztof M. Gorski, K. Ganga, A. Marcos-Caballero, C. Combet, Hannu Kurki-Suonio, E. Di Valentino, Jose M. Diego, L. Montier, Jan Hamann, J. F. Macías-Pérez, E. Franceschi, Charles R. Lawrence, M. Douspis, Erminia Calabrese, E. P. S. Shellard, Frederico Arroja, M. Le Jeune, P. Vielva, Andrea Zacchei, Graca Rocha, Martina Gerbino, Zhiqi Huang, Davide Maino, Adam Moss, Ricardo Genova-Santos, D. Tavagnacco, M. López-Caniego, A. A. Fraisse, M. Tenti, F. Piacentini, J.-P. Bernard, P. de Bernardis, Tiziana Trombetti, L. Toffolatti, Soumen Basak, F. Elsner, J.-L. Puget, Benjamin D. Wandelt, Julian Borrill, R. B. Barreiro, Gabriel Jung, Michele Liguori, S. Galeotta, Will Handley, F. Cuttaia, G. Polenta, R. C. Butler, K. Kiiveri, Anthony Lasenby, Alessandro Melchiorri, Reijo Keskitalo, A. J. Banday, M.-A. Miville-Deschênes, A. Renzi, P. Bielewicz, F. Oppizzi, Yashar Akrami, Anthony Challinor, B. Casaponsa, E. Keihänen, Gianmarco Maggio, B. P. Crill, Nicola Bartolo, B. Van Tent, Fabrizio Villa, Francesca Perrotta, F. K. Hansen, J. B. Kim, G. Sirri, Andrei V. Frolov, Michele Maris, J. A. Tauber, M. Savelainen, D. Herranz, A.-S. Suur-Uski, Yabebal Fantaye, Sabino Matarrese, M. Migliaccio, M. Tomasi, M. Bucher, Nicola Vittorio, J. Valiviita, V. Lindholm, W. C. Jones, Douglas Scott, R. Fernandez-Cobos, D. Paoletti, Marco Bersanelli, Torsten A. Enßlin, A. Moneti, M. Frailis, Carlo Baccigalupi, V. Pettorino, François Levrier, E. Hivon, J. Aumont, B. Racine, A. Mennella, G. Patanchon, Alessandro Gruppuso, Ingunn Kathrine Wehus, M. Reinecke, J.-M. Delouis, P. D. Meerburg, Massimiliano Lattanzi, Jose Alberto Rubino-Martin, N. Mandolesi, Chiara Sirignano, Kendrick M. Smith, Andrew H. Jaffe, Peter Meinhold, J.-M. Lamarre, A. de Rosa, G. de Zotti, B. Partridge, J. González-Nuevo, A. Ducout, Locke D. Spencer, M. Ashdown, H. K. Eriksen, Martin Kunz, Mathieu Remazeilles, Jon E. Gudmundsson, L. P. L. Colombo, Jason D. McEwen, Mario Ballardini, Peter G. Martin, George Efstathiou, Serge Gratton, Carlo Burigana, Nicoletta Krachmalnicoff, Yin-Zhe Ma, Jacques Delabrouille, Fabio Finelli, L. Pagano, N. Mauri, S. Dusini, Andrea Zonca, R. A. Sunyaev, P. B. Lilje, Luca Stanco, H. C. Chiang, K. Benabed, J. R. Bond, B. Ruiz-Granados, O. Doré, Paolo Natoli, Maresuke Shiraishi, Moritz Münchmeyer, S. Galli, Gianluca Morgante, Astrophysique, Laboratoire de physique de l'ENS - ENS Paris (LPENS (UMR_8023)), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), University of Parma = Università degli studi di Parma [Parme, Italie], Canadian Institute for Theoretical Astrophysics (CITA), Lawrence Berkeley National Laboratory [Berkeley] (LBNL), Patrimoine, Littérature, Histoire (PLH), Université Toulouse - Jean Jaurès (UT2J), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Universidade Aberta [Lisboa], Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Dipartimento di Fisica [Roma La Sapienza], Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratory for Phytosanitary Diagnostics and Forecasts, All-Russian Institute for Plant Protection, Russian Academy of Sciences [Moscow] (RAS), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Department of Atmospheric, Oceanic, and Space Sciences [Ann Arbor] (AOSS), University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique (LERMA (UMR_8112)), Sorbonne Université (SU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), ICRA and Physics Department, Dipartimento di Fisica 'G. Galilei', Universita degli Studi di Padova, University of Cambridge [UK] (CAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), University of Manchester [Manchester], University of British Columbia (UBC), Laboratoire de neurobiologie cellulaire et moléculaire (NBCM), Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Planck Collaboration, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2020-....] (UGA [2020-....])-Institut polytechnique de Grenoble - Grenoble Institute of Technology [2020-....] (Grenoble INP [2020-....]), Université Grenoble Alpes [2020-....] (UGA [2020-....]), Sorbonne Université (SU)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Théorique d'Orsay [Orsay] (LPT), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Planck, Department of Physics, Helsinki Institute of Physics, Universidad de Cantabria, Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique de l'ENS - ENS Paris (LPENS), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Sorbonne Université (SU)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Sorbonne Université (SU)-École normale supérieure - Paris (ENS Paris), High-Energy Frontier, Van Swinderen Institute for Particle Physics and G, Ministerio de Economía y Competitividad (España), Consejo Superior de Investigaciones Científicas (España), European Commission, European Research Council, European Space Agency, Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Département de Physique de l'ENS-PSL, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Département de Physique de l'ENS-PSL, Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Università degli studi di Parma = University of Parma (UNIPR), Université de Toulouse (UT)-Université de Toulouse (UT), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Padova = University of Padua (Unipd), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Y. Akrami, F. Arroja, M. Ashdown, J. Aumont, C. Baccigalupi, M. Ballardini, A. J. Banday, R. B. Barreiro, N. Bartolo, S. Basak, K. Benabed, J. -P. Bernard, M. Bersanelli, P. Bielewicz, J. R. Bond, J. Borrill, F. R. Bouchet, M. Bucher, C. Burigana, R. C. Butler, E. Calabrese, J. -F. Cardoso, B. Casaponsa, A. Challinor, H. C. Chiang, L. P. L. Colombo, C. Combet, B. P. Crill, F. Cuttaia, P. de Bernardi, A. de Rosa, G. de Zotti, J. Delabrouille, J. -M. Deloui, E. Di Valentino, J. M. Diego, O. Doré, M. Douspi, A. Ducout, X. Dupac, S. Dusini, G. Efstathiou, F. Elsner, T. A. Enßlin, H. K. Eriksen, Y. Fantaye, J. Fergusson, R. Fernandez-Cobo, F. Finelli, M. Fraili, A. A. Fraisse, E. Franceschi, A. Frolov, S. Galeotta, K. Ganga, R. T. Génova-Santo, M. Gerbino, J. González-Nuevo, K. M. Górski, S. Gratton, A. Gruppuso, J. E. Gudmundsson, J. Hamann, W. Handley, F. K. Hansen, D. Herranz, E. Hivon, Z. Huang, A. H. Jaffe, W. C. Jone, G. Jung, E. Keihänen, R. Keskitalo, K. Kiiveri, J. Kim, N. Krachmalnicoff, M. Kunz, H. Kurki-Suonio, J. -M. Lamarre, A. Lasenby, M. Lattanzi, C. R. Lawrence, M. Le Jeune, F. Levrier, A. Lewi, M. Liguori, P. B. Lilje, V. Lindholm, M. López-Caniego, Y. -Z. Ma, J. F. Macías-Pérez, G. Maggio, D. Maino, N. Mandolesi, A. Marcos-Caballero, M. Mari, P. G. Martin, E. Martínez-González, S. Matarrese, N. Mauri, J. D. McEwen, P. D. Meerburg, P. R. Meinhold, A. Melchiorri, A. Mennella, M. Migliaccio, M. -A. Miville-Deschêne, D. Molinari, A. Moneti, L. Montier, G. Morgante, A. Mo, M. Münchmeyer, P. Natoli, F. Oppizzi, L. Pagano, D. Paoletti, B. Partridge, G. Patanchon, F. Perrotta, V. Pettorino, F. Piacentini, G. Polenta, J. -L. Puget, J. P. Rachen, B. Racine, M. Reinecke, M. Remazeille, A. Renzi, G. Rocha, J. A. Rubiño-Martín, B. Ruiz-Granado, L. Salvati, M. Savelainen, D. Scott, E. P. S. Shellard, M. Shiraishi, C. Sirignano, G. Sirri, K. Smith, L. D. Spencer, L. Stanco, R. Sunyaev, A. -S. Suur-Uski, J. A. Tauber, D. Tavagnacco, M. Tenti, L. Toffolatti, M. Tomasi, T. Trombetti, J. Valiviita, B. Van Tent, P. Vielva, F. Villa, N. Vittorio, B. D. Wandelt, I. K. Wehu, A. Zacchei, A. Zonca, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)

Subjects
High Energy Physics - Theory, cosmological model, Astronomy, Cosmic microwave background, POLARIZATION ANISOTROPIES, cosmic background radiation: polarization, Astrophysics, cosmic background radiation, Cosmic background radiation, Early Universe, 01 natural sciences, 7. Clean energy, expansion: multipole, General Relativity and Quantum Cosmology, High Energy Physics - Phenomenology (hep-ph), cosmology: theory, 3-POINT CORRELATION-FUNCTION, observations [Cosmology], data analysis [Methods], 010303 astronomy & astrophysics, TEMPERATURE, Physics, [PHYS.HTHE]Physics [physics]/High Energy Physics - Theory [hep-th], hep-th, formation, hep-ph, early Universe, CMB cold spot, inflation: model, High Energy Physics - Phenomenology, scale dependence, non-Gaussianity, symbols, Sunyaev-Zel'dovich effect, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], astro-ph.CO, Trispectrum, Astrophysics - Cosmology and Nongalactic Astrophysics, Particle physics, data analysis method, Cosmology and Nongalactic Astrophysics (astro-ph.CO), satellite: Planck, gr-qc, FOS: Physical sciences, PREDICTIONS, General Relativity and Quantum Cosmology (gr-qc), Astrophysics::Cosmology and Extragalactic Astrophysics, Sunyaev–Zel'dovich effect, Separable space, NO, isocurvature, symbols.namesake, trispectrum, Settore FIS/05 - Astronomia e Astrofisica, parity: violation, gravitation: lens, statistical analysis, theory [Cosmology], Non-Gaussianity, 0103 physical sciences, BISPECTRUM, INFRARED BACKGROUND ANISOTROPIES, structure, bispectrum: scale dependence, Planck, cosmic background radiation: bispectrum, inflation, FAST ESTIMATOR, numerical calculations, non-Gaussianity: primordial, 010308 nuclear & particles physics, ISOCURVATURE PERTURBATIONS, Astronomy and Astrophysics, stability, 115 Astronomy, Space science, Inflation, methods: data analysis, boundary condition, cosmic background radiation: temperature, Cosmology: observations, Cosmology: theory, Methods: data analysis, High Energy Physics - Theory (hep-th), 13. Climate action, Space and Planetary Science, axion, [PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph], cosmology: observations, Cosmic background radiation, Cosmology: observations, Cosmology: theory, Early Universe, Inflation, Methods: data analysis, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Bispectrum
Abstract

Planck Collaboration: et al., arXiv:1905.05697v1, We analyse the Planck full-mission cosmic microwave background (CMB) temperature and E-mode polarization maps to obtain constraints on primordial non-Gaussianity (NG). We compare estimates obtained from separable template-fitting, binned, and optimal modal bispectrum estimators, finding consistent values for the local, equilateral, and orthogonal bispectrum amplitudes. Our combined temperature and polarization analysis produces the following final results: fNLlocal = −0.9 ± 5.1; fNLequil = −26 ± 47; and fNLortho = −38 ± 24 (68% CL, statistical). These results include low-multipole (4 ≤ ℓ < 40) polarization data that are not included in our previous analysis. The results also pass an extensive battery of tests (with additional tests regarding foreground residuals compared to 2015), and they are stable with respect to our 2015 measurements (with small fluctuations, at the level of a fraction of a standard deviation, which is consistent with changes in data processing). Polarization-only bispectra display a significant improvement in robustness; they can now be used independently to set primordial NG constraints with a sensitivity comparable to WMAP temperature-based results and they give excellent agreement. In addition to the analysis of the standard local, equilateral, and orthogonal bispectrum shapes, we consider a large number of additional cases, such as scale-dependent feature and resonance bispectra, isocurvature primordial NG, and parity-breaking models, where we also place tight constraints but do not detect any signal. The non-primordial lensing bispectrum is, however, detected with an improved significance compared to 2015, excluding the null hypothesis at 3.5σ. Beyond estimates of individual shape amplitudes, we also present model-independent reconstructions and analyses of the Planck CMB bispectrum. Our final constraint on the local primordial trispectrum shape is gNLlocal = (−5.8 ± 6.5) × 104 (68% CL, statistical), while constraints for other trispectrum shapes are also determined. Exploiting the tight limits on various bispectrum and trispectrum shapes, we constrain the parameter space of different early-Universe scenarios that generate primordial NG, including general single-field models of inflation, multi-field models (e.g. curvaton models), models of inflation with axion fields producing parity-violation bispectra in the tensor sector, and inflationary models involving vector-like fields with directionally-dependent bispectra. Our results provide a high-precision test for structure-formation scenarios, showing complete agreement with the basic picture of the ΛCDM cosmology regarding the statistics of the initial conditions, with cosmic structures arising from adiabatic, passive, Gaussian, and primordial seed perturbations., The Planck Collaboration acknowledges the support of: ESA; CNES and CNRS/INSU-IN2P3-INP (France); ASI, CNR, and INAF (Italy); NASA and DoE (USA); STFC and UKSA (UK); CSIC, MINECO, JA, and RES (Spain); Tekes, AoF, and CSC (Finland); DLR and MPG (Germany); CSA (Canada); DTU Space (Denmark); SER/SSO (Switzerland); RCN (Norway); SFI (Ireland); FCT/MCTES (Portugal); and ERC and PRACE (EU).

Published
2020
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29. Detection of KPC-216, a Novel KPC-3 Variant, in a Clinical Isolate of Klebsiella pneumoniae ST101 Co-Resistant to Ceftazidime-Avibactam and Cefiderocol.

Author

Giufrè M, Errico G, Del Grosso M, Pagnotta M, Palazzotti B, Ballardini M, Pantosti A, Meledandri M, and Monaco M

Abstract

Background: Carbapenemase-producing Klebsiella pneumoniae (CP-KP) represents a global threat to public health, with limited antimicrobial therapeutic options. In this study, we analyzed a ceftazidime/avibactam (CAZ-AVI)-resistant K. pneumoniae isolate obtained from a patient previously exposed to CAZ-AVI expressing a novel K. pneumoniae carbapenemase (KPC)-3 variant., Methods: Antimicrobial susceptibility testing was performed using reference broth microdilution. Whole-genome sequencing (WGS) was performed using Illumina and Nanopore Technologies. Short- and long-reads were combined with Unicycler. Assemblies were investigated for multilocus sequence typing (MLST), antimicrobial resistance genes, porins, and plasmids., Results: The K . pneumoniae isolate (KP&#95;RM&#95;1) was resistant to CAZ-AVI, expanded-spectrum cephalosporins, amikacin, ertapenem, and cefiderocol (FDC) but was susceptible to tigecycline, colistin, trimethoprim/sulfamethoxazole, meropenem-vaborbactam, and imipenem-relebactam. WGS revealed that the KP&#95;RM&#95;1 genome is composed of a single chromosome of 5 Mbp and five circular plasmids. Further analysis showed the presence of novel bla KPC-216 located on a 72 kb plasmid. KPC-216 differs from KPC-3 by a Lysin (K) insertion at position 168 (+K168)., Conclusions: We report the identification of a new KPC-3 variant associated with CAZ-AVI resistance. The KPC variants associated with CAZ-AVI resistance should be determined to promptly inform clinicians and start the appropriate antimicrobial therapy.

Published
2024
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30. Immigration as the main driver of population dynamics in a cryptic cetacean.

Author

Tenan S, Moulins A, Tepsich P, Bocconcelli A, Verga A, Ballardini M, Nani B, Papi D, Motta G, Aguilar AS, and Rosso M

Abstract

Empirical evidence about the role and interaction of immigration with local demographic processes in shaping population dynamics is still scarce. This knowledge gap limits our capability to derive a conceptual framework that can be used to inform conservation actions. Populations exposed to nonstationary environment do not converge to a stable stage distribution, implying the need for evaluating the demographic role of both vital rates and stage distribution using appropriate tools. This is particularly important for species with larger generation times like cetaceans. We explored the relative demographic role of vital rates and population structure of a poorly known cetacean, the Mediterranean Cuvier's beaked whale, while accounting for the exposure to nonstationary environments. We performed a retrospective analysis through transient life table response experiments (tLTRE) using demographic rates and population structure of both sexes obtained from an integrated population model. The contribution of immigration to variation in realized population growth rates was 4.2, 7.6, and 12.7 times larger than that of female apparent survival, proportional abundance of breeding females with a 2-year-old calf, and proportional abundance of breeding females with a 3-year-old calf, respectively. Immigration rate and proportional abundance of breeding females with a 2- or 3-year-old calf explained, respectively, 65% and 20% of total temporal variability in realized population growth rates. Changes in realized population growth rate between successive years were mainly driven by changes in immigration and population structure, specifically the proportional abundance of breeding females with a 2-year-old calf. Our study provides insight into the demographic processes that affect population dynamics and in a cryptic cetacean. We presented an analytical approach for maximizing the use of available data through the integration of multiple sources of information for individuals of different distinctiveness levels., (© 2023 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd.)

Published
2023
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31. First evidence of pyrethroid resistance in Italian populations of West Nile virus vector Culex pipiens.

Author

Pichler V, Giammarioli C, Bellini R, Veronesi R, Arnoldi D, Rizzoli A, Lia RP, Otranto D, Ballardini M, Cobre P, Serini P, Della Torre A, and Caputo B

Subjects
Animals, Italy, Mosquito Vectors, Permethrin, Culex genetics, Culex virology, Insecticide Resistance genetics, Insecticides, Pyrethrins, West Nile virus
Abstract

Culex pipiens (Linnaeus), one of the most abundant mosquito species in Europe, plays a crucial role in the endemic transmission of West Nile virus and caused the large outbreak with >1600 human cases in 2018. Although evidence of resistance to pyrethroids has been reported for Cx. pipiens populations from Spain and Greece, resistance monitoring has been largely neglected in Italy. Herein, we investigate susceptibility of Italian Cx. pipiens populations to the pyrethroids permethrin and deltamethrin. Results from WHO-tube-bioassays revealed mortalities ranging from 14-54%, indicating high levels of resistance, in four out of 10 populations exposed to permethrin (0.75%) and of 63% in one of three populations exposed to deltamethrin (0.05%). Reduced susceptibility (mortality<98%) was detected in almost all other populations. A clear association is shown between the resistant phenotype and the presence of kdr-alleles in position 1014 of the VSSC, strongly suggesting its role in reducing susceptibility. The study provides the first evidence of pyrethroid-resistance in Italian Cx. pipiens populations and reports levels of resistance paralleled in the European region only in Turkey. This highlights the urgent need to implement insecticide-resistance management plans to restore the efficacy of the nowadays only chemical weapon available to control arbovirus transmission in Europe., (© 2022 The Authors. Medical and Veterinary Entomology published by John Wiley & Sons Ltd on behalf of Royal Entomological Society.)

Published
2022
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32. Complement Activation Profile in Myasthenia Gravis Patients: Perspectives for Tailoring Anti-Complement Therapy.

Author

Iacomino N, Vanoli F, Frangiamore R, Ballardini M, Scandiffio L, Bortone F, Andreetta F, Baggi F, Bernasconi P, Antozzi C, Cavalcante P, and Mantegazza R

Abstract

The complement system plays a key role in myasthenia gravis (MG). Anti-complement drugs are emerging as effective therapies to treat anti-acetylcholine receptor (AChR) antibody-positive MG patients, though their usage is still limited by the high costs. Here, we searched for plasma complement proteins as indicators of complement activation status in AChR-MG patients, and potential biomarkers for tailoring anti-complement therapy in MG. Plasma was collected from AChR-MG and MuSK-MG patients, and healthy controls. Multiplex immunoassays and ELISA were used to quantify a panel of complement components (C1Q, C2, C3, C4, C5, Factor B, Factor H, MBL, and properdin) and activation products (C4b, C3b, C5a, and C5b-9), of classical, alternative and lectin pathways. C2 and C5 levels were significantly reduced, and C3, C3b, and C5a increased, in plasma of AChR-MG, but not MuSK-MG, patients compared to controls. This protein profile was indicative of complement activation. We obtained sensitivity and specificity performance results suggesting plasma C2, C3, C3b, and C5 as biomarkers for AChR-MG. Our findings reveal a plasma complement "C2, C3, C5, C3b, and C5a" profile associated with AChR-MG to be further investigated as a biomarker of complement activation status in AChR-MG patients, opening new perspectives for tailoring of anti-complement therapies to improve the disease treatment.

Published
2022
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33. A case report on fatal intoxication by tapentadol: Study of distribution and metabolism.

Author

Carelli C, Freni F, Moretti M, Vignali C, Ballardini M, and Morini L

Subjects
Adult, Analgesics, Opioid analysis, Benzodiazepines analysis, Bile chemistry, Chromatography, Liquid, Diazepam analysis, Dibenzothiazepines analysis, Gas Chromatography-Mass Spectrometry, Gastrointestinal Contents chemistry, Hair chemistry, Humans, Male, Nordazepam analogs & derivatives, Nordazepam analysis, Prisoners, Tapentadol analysis, Tranquilizing Agents analysis, Valproic Acid analysis, Analgesics, Opioid poisoning, Tapentadol poisoning
Abstract

We report a case in which a tapentadol acute intoxication was suspected as the cause of death of a 39-year-old man: approximately two days after death, cardiac and femoral blood, as well as urine, bile, gastric content and chest hair, were collected during the autopsy. Tapentadol was detected before and after hydrolysis in femoral (530 ng/mL unconjugated and 1570 ng/mL conjugated) and cardiac (680 ng/mL unconjugated and 3440 ng/mL conjugated) blood, and additionally in bile (3200 ng/mL), urine (9300 ng/mL), chest hair (2850 pg/mg) and gastric content. LC-QTOF screening analysis confirmed the presence of five different tapentadol metabolites (tapentadol-O-glucuronide, tapentadol-O-sulfate, N-desmethyltapentadol, N-desmethyltapentadol-glucuronide and N-desmethyltapentadol-O-sulfate), in urine, bile, cardiac and femoral blood. Positivity of body hairs allowed us to conclude that the man had used tapentadol in the last weeks/months. Autopsy and toxicological results (also positive for clotiapine, diazepam and chlordesmethyldiazepam) suggested that tapentadol could have caused, even at low concentrations, a severe respiratory depression, which contributed to the death of the subject. This is one of the few cases in literature where tapentadol was detected in blood, together with its metabolites, and the only one in which the parent drug was identified in hairs., (Copyright © 2021 Elsevier B.V. All rights reserved.)

Published
2021
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34. Fatal poisoning of four workers in a farm: Distribution of hydrogen sulfide and thiosulfate in 10 different biological matrices.

Author

Moretti M, Ballardini M, Siodambro C, Tronconi L, Osculati AMM, Freni F, Vignali C, and Morini L

Subjects
Adipose Tissue chemistry, Adult, Animals, Bile chemistry, Brain Chemistry, Humans, Liver chemistry, Lung chemistry, Male, Middle Aged, Muscle, Skeletal chemistry, Occupational Exposure adverse effects, Spleen chemistry, Air Pollutants poisoning, Farmers, Hydrogen Sulfide poisoning, Manure, Sulfides analysis, Thiosulfates analysis
Abstract

We evaluate the distribution of sulfide and thiosulfate (TS) in biological samples of four dairy farmers died inside a pit connected to a manure lagoon. Autopsies were performed 4 days later. Toxicological analyses of sulfide and TS were made using an extractive alkylation technique combined with gas chromatography/mass spectrometry (GC/MS). Autopsies revealed: multiorgan congestion; pulmonary edema; manure inside distal airways of three of the four victims. Sulfide concentrations were cardiac blood: 0.5-3.0 μg/mL, femoral blood: 0.5-1.2 μg/mL, bile: <0.1-2.2 μg/mL; liver 2.8-8.3 μg/g, lung: 5.0-9.4 μg/g, brain: 2.7-13.9 μg/g, spleen: 3.3-6.3 μg/g, fat: <0.1-1.5 μg/g, muscle: 2.6-3.5 μg/g. TS concentrations were cardiac blood: 2.1-4.9 μg/mL, femoral blood: 2.1-2.3 μg/mL, bile: 2.5-4.4 μg/mL, urine: <0.5-1.8 μg/mL; liver <0.5-2.6, lung: 2.8-5.4 μg/g, brain: <0.5-1.9 μg/g, spleen: 1.2-2.9 μg/g, muscle: <0.5-5.6 μg/g. The cause of death was assessed to be acute poisoning by hydrogen sulfide (H 2 S) for all the victims. Manure inhalation contributed to the death of three subjects. The measurement of sulfide and TS concentrations in biological samples contributed to better understand the sequence of the events. Subjects 3 provided the highest concentration of sulfide in brain, thus, supporting the hypothesis of a rapid loss of consciousness and respiratory depression. One by one, the other farmers entered the pit in attempts to rescue the coworkers but collapsed. Despite the rapid death, subject 3 was the only one with TS detectable in urine. This could be due to differences in metabolism of H 2 S., Competing Interests: Declaration of Competing Interest The authors report no declarations of interest., (Copyright © 2020 Elsevier B.V. All rights reserved.)

Published
2020
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35. A unique case of traumatic pulmonary food embolism.

Author

Lanzillotta F, Visonà SD, Ballardini M, Javan GT, and Osculati A

Subjects
Accidents, Traffic, Adult, Autopsy, Food, Humans, Male, Abdominal Injuries complications, Lung pathology, Pulmonary Embolism etiology, Thoracic Injuries complications, Wounds, Nonpenetrating complications
Abstract

We report a unique case of post-traumatic pulmonary food embolism, due to a lethal blunt force trauma occurred in a traffic accident. The subject was a 37-year old man, victim of a road traffic accident while he was riding his motorbike. A forensic autopsy, followed by histological examination, was ordered in order to find out the cause of death and to assess the compatibility of the lesions with the dinamic of the accident. Autopsy revealed a blunt force thoraco-abdominal trauma responsible of the death. The most interesting histological evidences concerned lungs. Here, inside arterious and arteriolar pulmonary vessels, we identified crystal-like corpuscles, of various shape and size, sometimes aggregated in small masses and thin vegetal fibers, refracting at polarized light, both PAS-positive and meat fibers shadows. The presence of alimentary material in the pulmonary vessels was explained by a pulmonary food embolism. The occurring of this kind of embolism implies a communication between the viscera lumen and the venous circulation of his wall (through a small wall rupture) in presence of cardiocirculatory activity, and provides, therefore, a strong proof of vitality., Competing Interests: Declaration of competing interest None., (Copyright © 2020 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.)

Published
2020
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36. Phenotypic and genotypic pyrethroid resistance of Aedes albopictus, with focus on the 2017 chikungunya outbreak in Italy.

Author

Pichler V, Malandruccolo C, Serini P, Bellini R, Severini F, Toma L, Di Luca M, Montarsi F, Ballardini M, Manica M, Petrarca V, Vontas J, Kasai S, Della Torre A, and Caputo B

Subjects
Aedes genetics, Animals, Chikungunya Fever prevention & control, Disease Outbreaks prevention & control, Genotype, Italy, Phenotype, Aedes drug effects, Insecticide Resistance genetics, Nitriles pharmacology, Permethrin pharmacology, Pyrethrins pharmacology
Abstract

Background: The highly invasive mosquito species Aedes albopictus has become a major health concern in temperate areas due to its role as vector of exotic arboviruses. Pyrethroid insecticides represent the main tools for limiting the circulation of such mosquito-borne viruses. The present work aim to extend previous reports on phenotypic pyrethroid-resistance in European Ae. albopictus, to identify its genetic basis and to monitor the geographical distribution of resistant genotypes, with a particular focus on sites experiencing the 2017 chikungunya outbreak in Italy., Results: Bioassays, performed according to World Health Organization protocols, showed full susceptibility to deltamethrin (concentration = 0.05%) and varying levels of resistance to permethrin (0.75%) and/or α-cypermethrin (0.05%) across Italy, with highest levels in the core of the 2017 chikungunya outbreak. Partial genotyping of the VSSC gene revealed widespread distribution of V1016G mutation and confirmed its association with pyrethroid resistance., Conclusion: The results obtained show that the condition for the spread of pyrethroid resistance in Ae. albopictus in Europe exists under strong selective pressure due to intensive insecticide spraying to control exotic arbovirus outbreak or high levels of nuisance. The results draw attention to the need for an evidence-based implementation of mosquito nuisance control, taking insecticide resistance management into consideration. © 2019 Society of Chemical Industry., (© 2019 Society of Chemical Industry.)

Published
2019
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38. First report of the invasive mosquito Aedes koreicus (Diptera: Culicidae) and of its establishment in Liguria, northwest Italy.

Author

Ballardini M, Ferretti S, Chiaranz G, Pautasso A, Riina MV, Triglia G, Verna F, Bellavia V, Radaelli MC, Berio E, Accorsi A, De Camilli M, Cardellino U, Fiorino N, Acutis PL, Casalone C, and Mignone W

Subjects
Aedes genetics, Airports, Animals, Entomology, Female, Introduced Species, Italy, Male, Mosquito Vectors genetics, Seasons, Aedes classification, Mosquito Vectors classification
Abstract

Background: Invasive mosquito species (IMS) of the genus Aedes are a cause of increasing concern in Europe owing to their ability to vector important human viral diseases. Entomological surveillance to early detect alien mosquito and flavivirus circulation in Liguria, northwest Italy, has been carried out since 2011., Results: The invasive species Aedes koreicus was first detected in Genoa in September 2015, when a male specimen was caught near the international airport; species identity was confirmed by genetic analysis. Over the next three years, 86 more adult specimens were trapped at sites throughout the city, accounting for 0.50% of all mosquitoes and 1.04% of Aedes sp. mosquitoes trapped in Genova in the four-year period 2015-2018. So far, no other monitored sites in Liguria have revealed the presence of this species. Ovitraps at two sites became positive for the species in July-August 2017. All female Ae. koreicus pools analysed were negative in biomolecular assays for Flavivirus., Conclusions: Our findings of Ae. koreicus in Genoa constitute, to the best of our knowledge, the first report of the species in northwest Italy and in a Mediterranean port city. The species appears to be established; trapping and climatic data support survival of Ae. koreicus in the area through three consecutive winters. Monitoring of adult mosquitoes detected the species two years before its discovery with ovitraps; trapping for adult specimens appears to be a more effective tool for the early detection of IMS. The airport (located near the commercial port area) and the flower market are the most probable sites of introduction; however, the exact time and place of arrival of this IMS in Liguria remain unknown. Based on morphological and genetic data, a common origin for most of the Ae. koreicus populations established in Europe is suspected. So far, no control measures have been adopted in Genoa and the species will probably colonize an even wider area in the next few years.

Published
2019
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39. Streptococcus pneumoniae primary peritonitis mimicking acute appendicitis in an immunocompetent patient: a case report and review of the literature.

Author

Cortese F, Fransvea P, Saputelli A, Ballardini M, Baldini D, Gioffre A, Marcello R, and Sganga G

Subjects
Abdomen, Acute etiology, Aged, Appendicitis diagnosis, Diagnosis, Differential, Humans, Immunocompetence, Peritonitis diagnosis, Pneumonia, Pneumococcal microbiology, Streptococcus pneumoniae isolation & purification, Peritonitis etiology, Pneumonia, Pneumococcal complications
Abstract

Introduction: Primary peritonitis without an identifiable intra-abdominal source is extremely rare in healthy individuals; it is commonly seen in cases of nephrotic syndrome, cirrhosis and end-stage liver disease, ascites, immunosuppression, and inflamed peritoneum due to pre-existing autoimmune and oncological conditions., Case Presentation: We present the case of a 68-year-old Caucasian woman operated on due to acute abdomen with a provisional diagnosis of acute appendicitis. During the operation a small amount of free intra-abdominal fluid was found. Her uterus, ovaries, and fallopian tubes were macroscopically normal. Therefore, with the suspicion of appendicitis, appendectomy was performed. Her blood cultures were negative while peritoneal fluid was positive for capsulated form of Streptococcus pneumoniae. A 30-day follow-up was performed and she was asymptomatic without any sign of infection., Discussion: Streptococcus pneumoniae commonly causes upper respiratory tract infection and cutaneous infections. It very rarely causes gastrointestinal infection and it is very rarely responsible for primary peritonitis and septic shock syndrome., Conclusion: Pneumococcal peritonitis has a rare occurrence and represents a clinical challenge because of its subtle and non-specific clinical findings. The interest in our case lays in the relatively rare diagnosis of primary peritonitis mimicking acute appendicitis.

Published
2019
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40. First report of Salmonella 1,4,[5],12:i:- in free-ranging striped dolphins (Stenella coeruleoalba), Italy.

Author

Grattarola C, Gallina S, Giorda F, Pautasso A, Ballardini M, Iulini B, Varello K, Goria M, Peletto S, Masoero L, Serracca L, Romano A, Dondo A, Zoppi S, Garibaldi F, Scaglione FE, Marsili L, Di Guardo G, Lettini AA, Mignone W, Fernandez A, and Casalone C

Subjects
Animals, Bacterial Typing Techniques, Coinfection microbiology, Drug Resistance, Multiple, Bacterial genetics, Fatal Outcome, Female, Italy, Male, Minisatellite Repeats genetics, Salmonella typhimurium isolation & purification, Coinfection veterinary, Salmonella Infections, Animal microbiology, Salmonella typhimurium genetics, Stenella microbiology
Abstract

Between 2015 and the beginning of 2018 (January-March), 30 cetaceans were found stranded along the Ligurian Sea coast of Italy. Necropsies were performed in 22 cases and infectious diseases resulted the most common cause of death. Three striped dolphins, showed a severe coinfection involving the monophasic variant of Salmonella Typhimurium (Salmonella 1,4,[5],12:i:-). The isolates were characterized based on antimicrobial resistance, Multiple-Locus Variable-number tandem-repeat Analysis (MLVA) and whole-genome sequencing (WGS). All isolates demonstrated the same multidrug resistant genotype (ASSuT isolates), showed three different MLVA profiles, two of which closely related, and were identified as Sequence Type 34. Moreover, Single nucleotide polymorphisms (SNP) analysis confirmed strong correlations between two out of the three isolates. To our knowledge, S. 1,4,[5],12:i:-, one of the most common serovars in cases of human infection and food sources worldwide, has not previously been described in marine mammals, and reports of Salmonella-associated disease in free-ranging cetaceans are rare. These results highlight the role of cetaceans as sentinel species for zoonotic and terrestrial pathogens in the marine environment, suggest a potential risk for cetaceans and public health along the North Western Italian coastline and indicate cetaceans as a novel potential reservoir for one of the most widespread Salmonella serovars.

Published
2019
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41. First evidence of resistance to pyrethroid insecticides in Italian Aedes albopictus populations 26 years after invasion.

Author

Pichler V, Bellini R, Veronesi R, Arnoldi D, Rizzoli A, Lia RP, Otranto D, Montarsi F, Carlin S, Ballardini M, Antognini E, Salvemini M, Brianti E, Gaglio G, Manica M, Cobre P, Serini P, Velo E, Vontas J, Kioulos I, Pinto J, Della Torre A, and Caputo B

Subjects
Aedes physiology, Animals, Female, Italy, Mosquito Vectors drug effects, Mosquito Vectors physiology, Aedes drug effects, Insecticide Resistance, Insecticides pharmacology, Nitriles pharmacology, Permethrin pharmacology, Pyrethrins pharmacology
Abstract

Background: Aedes albopictus has spread during the last few decades all over the world. This has increased significantly the risk of exotic arbovirus transmission (e.g. chikungunya, dengue, and Zika) also in temperate areas, as demonstrated by the Chikungunya 2007 and 2017 outbreaks in northeastern and central Italy. Insecticides are an important tool for limiting the circulation of these mosquito-borne viruses. The aim of the present study was to address the gap in current knowledge of pyrethroid insecticide resistance of European Ae. albopictus populations, focusing on populations from Italy, Albania and Greece., Results: Bioassays for resistance to permethrin (0.75%), α-cypermethrin (0.05%) or deltamethrin (0.05%) were performed according to World Health Organization (WHO) protocols and showed reduced susceptibility (<90% mortality) of some Italian populations to permethrin and α-cypermethrin, but not to deltamethrin., Conclusion: This study reports the first evidence of resistance to pyrethroids in adult Italian Ae. albopictus populations. Results refer to the season preceding the Chikungunya 2017 outbreak in central Italy and highlight the need to increase efforts to monitor the spread of insecticide resistance and the need to develop strategies to limit the spread of insecticide resistance, particularly in areas where extensive treatments have been carried out to contain disease outbreaks. © 2017 Society of Chemical Industry., (© 2017 Society of Chemical Industry.)

Published
2018
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42. Analysis of the environmental and host-related factors affecting the distribution of the tick Dermacentor marginatus.

Author

Selmi M, Tomassone L, Ceballos LA, Crisci A, Ragagli C, Pintore MD, Mignone W, Pautasso A, Ballardini M, Casalone C, and Mannelli A

Subjects
Animals, Ecosystem, France epidemiology, Incidence, Italy epidemiology, Risk, Tick Bites parasitology, Animal Distribution, Dermacentor physiology, Host-Parasite Interactions, Spotted Fever Group Rickettsiosis epidemiology, Sus scrofa parasitology, Tick Bites epidemiology
Abstract

Understanding and responding to the ecological, social and economic conditions that facilitate disease emergence and transmission represents a substantial challenge for epidemiologists and health professionals. In this article we integrate knowledge about the human and the vector population, to provide a context from which to examine the underlying causal factors of D. marginatus-borne diseases emergence in the study area. Within this framework we analyse the biotic and abiotic factors that drive D. marginatus population dynamics and the role of its typical host for dispersal. These investigations suggest that D. marginatus is a tick species prone to spatially overlap its presence with human population presence. Then we consider the public health implications for the residents, when simply carrying out trivial outdoor activities may increase the risk to contact an infected tick.

Published
2018
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43. NEUROPATHOLOGIC FINDINGS IN CETACEANS STRANDED IN ITALY (2002-14).

Author

Pintore MD, Mignone W, Di Guardo G, Mazzariol S, Ballardini M, Florio CL, Goria M, Romano A, Caracappa S, Giorda F, Serracca L, Pautasso A, Tittarelli C, Petrella A, Lucifora G, Di Nocera F, Uberti BD, Corona C, Casalone C, and Iulini B

Subjects
Animals, Brain Diseases pathology, Female, Italy epidemiology, Male, Brain Diseases veterinary, Dolphins, Whales
Abstract

We summarized the neuropathologic findings in 60 cetaceans stranded along the Italian coastline from 2002 to 2014. The following neuropathologic changes were detected in 45% (27/60) of animals: nonsuppurative meningo-encephalitides (30%, 18/60), nonspecific lesions (12%, 7/60), suppurative encephalitis (2%, 1/60), and neoplasm (2%, 1/60). No histologic lesions were found in 47% (28/60) of the specimens. Five (8%, 5/60) samples were unsuitable for analysis. Analysis with PCR detected Brucella spp., morbillivirus, and Toxoplasma gondii infection in one, six, and seven individuals, respectively. Immunohistochemical analysis confirmed positivity for morbillivirus and for T. gondii infection in three cases each. No evidence of the scrapie-associated prion protein PrPSc was detected. Our findings underscore the importance of an adequate surveillance system for monitoring aquatic mammal pathologies and for protecting both animal and human health.

Published
2018
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44. Occlusive mycotic tracheobronchitis and systemic Alphaherpesvirus coinfection in a free-living striped dolphin Stenella coeruleoalba in Italy.

Author

Grattarola C, Giorda F, Iulini B, Pautasso A, Ballardini M, Zoppi S, Marsili L, Peletto S, Masoero L, Varello K, Garibaldi F, Scaglione FE, Di Guardo G, Dondo A, Goria M, Serracca L, Mignone W, and Casalone C

Subjects
Animals, Bronchitis epidemiology, Bronchitis microbiology, Female, Herpesviridae Infections epidemiology, Herpesviridae Infections virology, Italy epidemiology, Phylogeny, Tracheitis epidemiology, Tracheitis microbiology, Alphaherpesvirinae isolation & purification, Bronchitis veterinary, Herpesviridae Infections veterinary, Mycoses veterinary, Stenella microbiology, Tracheitis veterinary
Abstract

A juvenile female striped dolphin Stenella coeruleoalba live stranded on 4 March 2016 at Alassio, western Ligurian Sea coast, Italy. The dolphin died shortly after stranding, and a complete postmortem examination was performed. Necropsy revealed severe tracheal occlusion and unilateral bronchial stenosis with luminal accumulation of abundant green-yellow mucous-gelatinous material. Histological features suggestive of tracheobronchial aspergillosis were observed. Cultures of lung tissue and tracheo-bronchial exudate isolated Aspergillus fumigatus, identified by a Microseq D2 LSUrDNA fungal sequencing kit. A pan-Herpesvirus nested-PCR assay on frozen samples obtained from multiple organs was positive. Phylogenetic analysis on the partial DNA polymerase gene revealed that the striped dolphin isolate was closely related to known cetacean Alphaherpesvirus sequences from the same host species. Attempted virus isolation was unsuccessful. The tissue levels of different persistent organic pollutants and the toxicological stress, evaluated using a theoretical model, showed a severely impaired immune response. This study reports the first case of occlusive mycotic tracheobronchitis in a free-living cetacean and the first molecular identification of an Alphaherpesvirus in a free-ranging striped dolphin stranded on the coast of Italy.

Published
2018
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45. POSTMORTEM FINDINGS IN CETACEANS FOUND STRANDED IN THE PELAGOS SANCTUARY, ITALY, 2007-14.

Author

Giorda F, Ballardini M, Di Guardo G, Pintore MD, Grattarola C, Iulini B, Mignone W, Goria M, Serracca L, Varello K, Dondo A, Acutis PL, Garibaldi F, Scaglione FE, Gustinelli A, Mazzariol S, Di Francesco CE, Tittarelli C, Casalone C, and Pautasso A

Subjects
Adrenal Cortex Neoplasms mortality, Adrenal Cortex Neoplasms veterinary, Adrenocortical Adenoma mortality, Adrenocortical Adenoma veterinary, Age Distribution, Animals, Animals, Newborn, Communicable Diseases mortality, Communicable Diseases veterinary, Female, Heart Diseases mortality, Heart Diseases veterinary, Hemorrhage mortality, Hemorrhage veterinary, Human Activities, Italy, Male, Nutritional Status, Urologic Diseases mortality, Urologic Diseases veterinary, Wounds and Injuries mortality, Wounds and Injuries veterinary, Autopsy veterinary, Cause of Death, Cetacea
Abstract

Between 2007 and 2014, 83 cetaceans were found stranded along the Ligurian coast of Italy, in the Pelagos Sanctuary, the largest marine protected area in the Mediterranean basin. Forty-nine (59%) were submitted to complete or partial necropsy, depending on the conservation status of the carcass. Based on gross and histological pathology and ancillary testing, the cause of death was determined and categorized as anthropogenic or natural (i.e., nonanthropogenic) in origin for 33 animals (67%) and of undetermined origin in the remaining 16 (33%). Natural causes of death, accompanied by either poor or good nutritional status, were attributed to 29 animals (59%), whereas four (8%) were diagnosed with an anthropogenic cause of death, consisting of interaction with fishing activities. Infectious and noninfectious disease was the most common cause of death, involving 29 cetaceans (59%). These data are valuable for understanding health and mortality trends in cetacean populations and can provide information for establishing policies for cetacean conservation and management in such an important protected area of the Mediterranean basin.

Published
2017
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46. Rickettsia spp. in Dermacentor marginatus ticks: analysis of the host-vector-pathogen interactions in a northern Mediterranean area.

Author

Selmi M, Ballardini M, Salvato L, and Ricci E

Subjects
Animals, Animals, Wild, Rickettsia Infections, Sus scrofa microbiology, Sus scrofa parasitology, Dermacentor microbiology, Host-Pathogen Interactions, Rickettsia growth & development
Abstract

In this work, we have analyzed the key features of Rickettsia spp. maintenance in Dermacentor marginatus ticks in four regions of the northern Mediterranean area, where extensive investigations are currently lacking. For this purpose, 380 adult D. marginatus ticks were collected from vegetation and wild ungulates during a 3-year study. A host-vector-pathogen interaction approach was applied to investigate the key components of the disease systems and evaluate their respective weight in the intensity of infection in natural foci. A high variability in the R. slovaca infection rate among sampling sites was observed, whereas R. raoultii was sporadically present and at low infection rates. Dermacentor marginatus presence was confirmed in all the investigated regions. The local wild boar population showed a strong association with adult D. marginatus ticks. The results of this investigation suggest that wild boars not only maintain D. marginatus populations by feeding adult ticks, but may also have a potential role in the eco-epidemiology of rickettsioses, as carriers of rickettsiae-infected ticks. The public health implications of these results are discussed.

Published
2017
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47. Q fever seroprevalence and risk factors in sheep and goats in northwest Italy.

Author

Rizzo F, Vitale N, Ballardini M, Borromeo V, Luzzago C, Chiavacci L, and Mandola ML

Subjects
Animals, Antibodies, Bacterial blood, Coxiella burnetii immunology, Coxiella burnetii isolation & purification, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay veterinary, Female, Goat Diseases blood, Goat Diseases microbiology, Goats, Italy epidemiology, Logistic Models, Male, Prevalence, Q Fever blood, Q Fever epidemiology, Risk Factors, Seroepidemiologic Studies, Sheep, Sheep Diseases blood, Sheep Diseases microbiology, Spatial Analysis, Goat Diseases epidemiology, Q Fever veterinary, Sheep Diseases epidemiology
Abstract

Q fever is a zoonosis caused by the bacterium Coxiella burnetii; domestic ruminants, mainly goats and sheep, are the main source of Q fever outbreaks in humans. From both a public and an animal health perspective, providing reliable prevalence data is extremely relevant for the decision processes by policymakers and food producer organizations. Information on Q fever seroprevalence in small ruminants in Italy is currently incomplete and largely based on reports of reproductive disorders in livestock farms. To estimate animal and flock seroprevalence of C. burnetii in small ruminants (sheep, goats and mixed flocks), a cross-sectional study with a two-stage design was carried out in northwest Italy. Between January and December 2012, sera from 5738 animals (2553 sheep and 3185 goats) belonging to 411 flocks (206 goats, 111 sheep, and 94 mixed flocks) were examined for specific anti-C. burnetii IgG antibodies by a commercial ELISA kit. A questionnaire investigating possible associations between farm management and C. burnetii seropositivity was administered. At the flock level, the overall true seroprevalence adjusted for test sensitivity and specificity was 31.2% (95% confidence interval [CI]: 24.8-37.7). Sheep-farm and goat-farm true seroprevalence was 38.7% (95% CI 25.5-51.9) and 19.5% (95% CI 11.5-27.6), respectively. Interestingly, the true seroprevalence (48.5%; 95% CI 34.7-62.3) was higher in the mixed flocks (sheep and goats). At the animal level, the overall true seroprevalence was 15.9% (95% CI 15.4-16.4). No difference was found between the two species, but the true seroprevalence was significantly higher (χ(2)=7.49; p<0.007) among the goats in mixed flocks (25.7%; 95% CI 24.4-27.1) than the sheep (16.3%; 95% CI 15.1-17.4), suggesting a potential difference in susceptibility between the two species or the result of factors affecting their immune response or related to the livestock management system as the period of exposure to C. burnetii. A multivariable logistic model that controlled for farm-level clustering identified five main risk factors associated with farm seropositivity (p≤0.05): flock size of more than 12 animals (odds ratio [OR] 4.2; 95% CI 2.6-6.7), contact with other flocks (OR 2.1; 95% CI 1.2-3.6), mixed flock type (OR 2.4; 95% CI 1.4-4.2), farms located in the western area (OR 2.4; 95% CI 1.4-4.2), and infertility during the previous year (OR 2.6; 95% CI 1.2-5.2). The results of this study yielded baseline information that may be useful to set up future epidemiologic, flock management, and public health policies for the prevention and control of Q fever in Italy., (Copyright © 2016 Elsevier B.V. All rights reserved.)

Published
2016
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48. Detection of West Nile and Usutu Viruses in Italian Free Areas: Entomological Surveillance in Piemonte and Liguria Regions, 2014.

Author

Pautasso A, Radaelli MC, Ballardini M, Francese DR, Verna F, Modesto P, Grattarola C, Desiato R, Bertolini S, Vitale N, Ferrari A, Rossini I, Accorsi A, Mosca A, Monaco F, Savini G, Prearo M, Mignone W, Chiavacci L, and Casalone C

Subjects
Animals, Flavivirus genetics, Horses immunology, Horses virology, Insect Vectors virology, Italy, RNA, Viral analysis, West Nile Fever immunology, West Nile Fever veterinary, West Nile virus genetics, Culicidae virology, Flavivirus isolation & purification, West Nile virus isolation & purification
Abstract

West Nile virus and Usutu virus have established in different parts of Italy over the past 10 years. Piemonte and Liguria Regions (Northwestern Italy) are known to be nonendemic areas, despite the presence of competent vectors and environmental conditions conducive to maintaining infection. This work evidences for the first time, through an entomological surveillance implemented on the basis of risk factor approach, the presence of West Nile and Usutu viruses in Piemonte and Liguria Regions (Northwestern Italy).

Published
2016
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49. In Vitro Activity of Tea Tree Oil Vaginal Suppositories against Candida spp. and Probiotic Vaginal Microbiota.

Author

Di Vito M, Mattarelli P, Modesto M, Girolamo A, Ballardini M, Tamburro A, Meledandri M, and Mondello F

Subjects
Candida albicans, Female, Humans, Lactobacillus, Middle Aged, Probiotics, Suppositories, Antifungal Agents, Candida drug effects, Microbiota drug effects, Tea Tree Oil, Vagina microbiology
Abstract

The aim of this work is to evaluate the in vitro microbicidal activity of vaginal suppositories (VS) containing tea tree oil (TTO-VS) towards Candida spp. and vaginal probiotics. A total of 20 Candida spp. strains, taken from patients with vaginitis and from an established type collection, including reference strains, were analysed by using the CLSI microdilution method. To study the action of VS towards the beneficial vaginal microbiota, the sensitivity of Bifidobacterium animalis subsp. lactis (DSM 10140) and Lactobacillus spp. (Lactobacillus casei R-215 and Lactobacillus acidophilus R-52) was tested. Both TTO-VS and TTO showed fungicidal activity against all strains of Candida spp. whereas placebo-VS or the Aloe gel used as controls were ineffective. The study of fractional fungicidal concentrations (FFC) showed synergistic interaction with the association between Amphotericin B and TTO (0.25 to 0.08 µg/ml, respectively) against Candida albicans. Instead, the probiotics were only affected by TTO concentration ≥ 4% v/v, while, at concentrations < 2% v/v, they remained viable. TTO-VS exhibits, in vitro, a selective fungicidal action, slightly affecting only the Bifidobacteriun animalis strain growth belonging to the vaginal microbiota. In vivo studies are needed to confirm the efficacy to prevent acute or recurrent vaginal candidiasis., (Copyright © 2015 John Wiley & Sons, Ltd.)

Published
2015
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50. Genetic structure of the date palm (Phoenix dactylifera) in the Old World reveals a strong differentiation between eastern and western populations.

Author

Zehdi-Azouzi S, Cherif E, Moussouni S, Gros-Balthazard M, Abbas Naqvi S, Ludeña B, Castillo K, Chabrillange N, Bouguedoura N, Bennaceur M, Si-Dehbi F, Abdoulkader S, Daher A, Terral JF, Santoni S, Ballardini M, Mercuri A, Ben Salah M, Kadri K, Othmani A, Littardi C, Salhi-Hannachi A, Pintaud JC, and Aberlenc-Bertoss F

Abstract

Since the publication of this paper, it has become apparent that an error was made in the legend to Fig. 3 and the colours referring to occidental and oriental are the wrong way round. The authors apologise for this error, and a correct version of the legend to Fig. 3 is given below.

Published
2015
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