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189 results on '"M. Bartolucci"'

1. Stochastic epigenetic mutations as possible explanation for phenotypical discordance among twins with congenital hypothyroidism

Author

D. Gentilini, M. Muzza, T. de Filippis, M. C. Vigone, G. Weber, L. Calzari, A. Cassio, M. Di Frenna, M. Bartolucci, E. S. Grassi, E. Carbone, A. Olivieri, L. Persani, Gentilini, D, Muzza, M, de Filippis, T, Vigone, M C, Weber, G, Calzari, L, Cassio, A, Di Frenna, M, Bartolucci, M, Grassi, E S, Carbone, E, Olivieri, A, and Persani, L

Subjects
Thyroid, Congenital disease, Endocrinology, Congenital diseases, Endocrinology, Diabetes and Metabolism, Genome-wide DNA methylation, Preterm delivery, Thyroid dysgenesis, Thyroid dysgenesi, Twin gestation, Settore MED/13 - Endocrinologia
Abstract

Purpose The elevated frequency of discordance for congenital hypothyroidism (CH) phenotype between monozygotic twins suggests the involvement of non-mendelian mechanisms. The aim of the study was to investigate the role of epigenetics in CH pathogenesis. Methods A genome-wide DNA methylation analysis was performed on the peripheral blood of 23 twin pairs (10 monozygotic and 13 dizygotic), 4 concordant and 19 discordant pairs for CH at birth. Results Differential methylation analysis did not show significant differences in methylation levels between CH cases and controls, but a different methylation status of several genes may explain the CH discordance of a monozygotic twin couple carrying a monoallelic nonsense mutation of DUOX2. In addition, the median number of hypo-methylated Stochastic Epigenetic Mutations (SEMs) resulted significantly increased in cases compared to controls. The prioritization analysis for CH performed on the genes epimutated exclusively in the cases identified SLC26A4, FOXI1, NKX2-5 and TSHB as the genes with the highest score. The analysis of significantly SEMs-enriched regions led to the identification of two genes (FAM50B and MEG8) that resulted epigenetically dysregulated in cases. Conclusion Epigenetic modifications may potentially account for CH pathogenesis and explain discordance among monozygotic twins.

Published
2022
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3. Neonatal screening for congenital hypothyroidism: what can we learn from discordant twins?

Author

E, Medda, primary, MC, Vigone, additional, A, Cassio, additional, F, Calaciura, additional, P, Costa, additional, G, Weber, additional, T, de Filippis, additional, G, Gelmini, additional, M, Di Frenna, additional, S, Caiulo, additional, R, Ortolano, additional, D, Rotondi, additional, M, Bartolucci, additional, R, Gelsomino, additional, S, De Angelis, additional, M, Gabbianelli, additional, L, Persani, additional, and A, Olivieri, additional

Published
2020
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4. Fragmentation studies with the CHIMERA detector at LNS in Catania: recent progress

Author

H. Wu, L. Auditore, J. Blicharska, M. Papa, G. Vannini, M. Trimarchi, S. M. Li, L. Zetta, Z. Majka, Angelo Pagano, S. Lo Nigro, M. L. Sperduto, T. Paduszynski, G. Lanzalone, G. Lanzanó, A. Chbihi, I. Skwira, M. Iacono-Manno, E. La Guidara, M.F Rivet, M. Bruno, J.P. Wieleczko, K. Siwek-Wilczyńska, Maria Colonna, R. Bougault, G.R. Sechi, E. Rosato, Monica Alderighi, Amalia Pop, V. Simion, J. Cibor, N. Le Neindre, J.C. Steckmeyer, F. Rizzo, F. Porto, E. De Filippo, L. Swiderski, P. Russotto, A. Anzalone, V. Baran, Zhigang Xiao, M. Bartolucci, R. Planeta, M. D'Agostino, J. Wilczynski, M. Di Toro, A. Bonasera, P. Guazzoni, A. Grzeszczuk, R. Dayras, S. Cavallaro, I. Berceanu, S. Russo, E. Geraci, F. Giustolisi, B. Borderie, J. Brzychczyk, M. Sassi, S. Kowalski, W. Gawlikowicz, E. Piasecki, A. Trifiro, Mariano Vigilante, G. Politi, L. Arena, S. Pirrone, W. Zipper, D. Guinet, G. Cardella, G. Manfredi, F. Amorini, C. Maiolino, M. Petrovici, M. B. Chatterjee, Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), A. Pagano, M. Alderighi, F. Amorini, A. Anzalone, L. Arena, L. Auditore, V. Baran, M. Bartolucci, I. Berceanu, J. Blicharska, J.Brzychczyk, A. Bonasera, B. Borderie, R. Bougault, M. Bruno, G.Cardella, S. Cavallaro, M.B. Chatterjee, A. Chbihi, J. Cibor, M.Colonna, M. D'Agostino, R. Dayra, E. De Filippo, M. Di Toro, W.Gawlikowicz, E. Geraci, F. Giustolisi, A. Grzeszczuk, P. Guazzoni, D.Guinet, M. Iacono-Manno, S. Kowalski, E. La Guidara, G. Lanzano', G.Lanzalone, N.Le Neindre, S. Li, S. Lo Nigro, C. Maiolino, Z. Majka, G. Manfredi, T. Paduszynski, M. Papa, M. Petrovici, E. Piasecki, S.Pirrone, R. Planeta, G. Politi, A. Pop, F. Porto, M.F. Rivet, E. Rosato, F. Rizzo, S. Russo, P. Russotto, M. Sassi, G. Sechi, V. Simion, K. Siwek-Wilczynska, I. Skwira, M.L. Sperduto, J.C. Steckmeyer, L. Swiderski, A. Trifiro`, M. Trimarchi, G. Vannini, M. Vigilante, J.P. Wieleczko, J. Wilczynski, H. Wu, Z. Xiao, L. Zetta, W. Zipper, and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
Nuclear reaction, Nuclear and High Energy Physics, APPARATO DI RIVELAZIONE, TECNICHE DI IDENTIFICAZIONE, REAZIONI NUCLEARI SEMI-PERIFERICHE, PRODUZIONE DI FRAMMENTI DI MASSA INTERMEDIA, TEMPI DI PRODUZIONE DEI FRAMMENTI, Cyclotron, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 7. Clean energy, 01 natural sciences, Particle identification, law.invention, Ion, Nuclear physics, law, 0103 physical sciences, Nuclear Experiment, 010306 general physics, Physics, 010308 nuclear & particles physics, Detector, Charged particle, Time of flight, Nucleon
Abstract

The new detector CHIMERA, in its final 4π configuration, has been installed at Laboratori Nazionali del Sud (LNS) in Catania in January 2003. Beams of different energies ranging from protons to Au ions were delivered by the Tandem and the Super Conducting Cyclotron for nuclear reaction studies, in agreement with the approval of the Scientific Advisory Committee of LNS. Recent experimental results confirm very low energy thresholds of the trigger (below 0.5 MeV/nucleon), ensured within a wide dynamical range. Good characteristics of identification of light charged particles and heavy fragments have been obtained by using three detection techniques: Δ E-E , Δ E -time of flight, and the Pulse-Shape discrimination method. We present results of recent analysis concerning the production of intermediate mass fragments (IMF) in semi-peripheral collisions. Our results combined with theoretical Boltzmann-Nordheim-Vlasov simulations clearly demonstrate the presence of very fast processes of IMF production in the overlapping region of the target and projectile nuclei during re-separation, i.e. in the time scale comparable with the collision time. Evidence for slower, sequential-like production of IMF's is also shown.

Published
2004
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5. 106. Parietal cortex involvement in visual perceptual learning: A rTMS investigation

Author

Fabio Giovannelli, Maria Pia Viggiano, M. Bartolucci, D. Battista, E. Del Sordo, Alessandra Borgheresi, Gaetano Zaccara, and Massimo Cincotta

Subjects
Visual perception, genetic structures, medicine.medical_treatment, Posterior parietal cortex, Sensory system, behavioral disciplines and activities, Sensory Systems, Transcranial magnetic stimulation, Visual cortex, medicine.anatomical_structure, Neurology, Orientation (mental), Learning curve, Perceptual learning, Physiology (medical), medicine, Neurology (clinical), Psychology, Neuroscience, Cognitive psychology
Abstract

Practice-induced visual perceptual learning is thought to reflect the plasticity of sensory brain regions. The hypothesis that changes in early visual areas may depend on top-down modulation from higher level brain regions by attentional mechanisms is still debated. We used a causal approach by repetitive transcranial magnetic stimulation (rTMS) to evaluate the role of primary visual cortex (V1) and posterior parietal cortex (PPC) in visual perceptual learning. Twelve healthy volunteers performed a forced-choice orientation discrimination task of gabor patches (consisting of 500 trials in five blocks) without any intervention or immediately after a conditioning inhibitory 1-Hz rTMS protocol delivered over the V1, the right PPC, and the vertex (control area), in four different days. Conditioning inhibition by 1-Hz rTMS over the V1 produced an overall worsening of the performance accuracy but no effect in the learning rate, as measured by the slope of the learning curve. The learning rate was lower after right PPC inhibition compared to the other conditions, when evaluated during the first two blocks (200 trials) where occurred most of the learning. These preliminary findings suggest that higher level brain regions may be involved in the mechanisms underlying perceptual learning.

Published
2016
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6. CHIMERA data acquisition and computational system using DSP-based VME modules

Author

M. Papa, F. Porto, O. Anzalone, M. Iacono-Manno, G. Lanzano, S. Russo, S. Pirrone, L. Zetta, E. Geraci, G. Lanzalone, M. Alderighi, F. Giustolisi, G. Manfredi, E. De Filippo, S. Cavallaro, L. Sperduto, A. Pagano, P. Guazzoni, G.R. Sechi, P. Opichal, M. Bartolucci, G. Cardella, and G. Politi

Subjects
Nuclear and High Energy Physics, Digital signal processor, Signal processing, business.industry, Computer science, System testing, Data acquisition, Nuclear Energy and Engineering, Eurocard, Central processing unit, Electrical and Electronic Engineering, business, Computer hardware, Digital signal processing, VMEbus
Abstract

We have built and tested a computational unit for on-line processing of special algorithms to be embedded in the central processing unit VERSAmodule Eurocard (CPU VME)-crate of the CHIMERA data acquisition system. The computational unit consists of a number of VME digital signal processor (DSP)-based commercial boards delivering 720 MFlops/board.

Published
2002
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7. Automatic analysis of CHIMERA experimental data by means of a hierarchical pre-attentive neural system

Author

G. Lanzano, M. L. Sperduto, S. Sambataro, M. Alderighi, S. Pirrone, A. Anzalone, G. Manfredi, G.R. Sechi, S. Cavallaro, G. Cardella, F. Giustolisi, F. Porto, M. Bartolucci, Luisa Zetta, M. Papa, P. Guazzoni, Angelo Pagano, E. Geraci, E. De Filippo, G. Politi, S. LoNigro, G. Lanzalone, and S. Russo

Subjects
Basis (linear algebra), Artificial neural network, Computer science, business.industry, General Physics and Astronomy, Experimental data, Context (language use), Field (computer science), Display device, Hardware and Architecture, Scatter plot, Neural system, Artificial intelligence, business
Abstract

Biological vision processes are at the basis of many studies in the image-processing field. In this context, neural networks developed by S. Grossberg constitute an interesting approach. The paper presents a novel method for the automatic analysis of scatter plots from CHIMERA experimental data based on Grossberg's pre-attentive neural systems. The design and implementation of a system developed for this purpose are illustrated. The proposed method yields satisfactory results also in very noisy cases.

Published
2001
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8. A spatial density analysis technique for the automatic classification of 4/spl pi/ detector data

Author

G. Lanzalone, S. Sambataro, E. De Filippo, F. Giustolisi, G. Cardella, A. Anzalone, R. Sechi, S. Russo, G. Manfredi, L. Sperduto, E. Geraci, F. Porto, S. Pirrone, G. Lanzano, L. Zetta, M. Bartolucci, G.R. Sechi, A. Pagano, P. Guazzoni, M. Alderighi, G. Politi, S. Cavallaro, A. Sala, Michele Papa, and S. LoNigro

Subjects
Physics, Nuclear and High Energy Physics, Data processing, Physics::Instrumentation and Detectors, Scattering, Detector, Scintillator, Spectral line, Reduction (complexity), Identification (information), Nuclear Energy and Engineering, Electronic engineering, Electrical and Electronic Engineering, Frequency distribution, Algorithm
Abstract

In nuclear physics at intermediate energies, the use of multidetector arrays consisting of thousands of detectors is customary. This paper presents a novel approach to the automatic classification of data collected by the 4/spl pi/ detector CHIMERA, constituted by 1192 telescopes of a thin silicon transparent detector coupled to a thick CsI(Tl) scintillator. The method is based on spatial density data processing and produces frequency distributions of the most significant physical parameters. These one-dimensional spectra can be more easily analyzed than the standard two-dimensional scatter plots. With respect to manual or semiautomatic procedures, presently used for data analysis, our method offers the advantages of drastic time reduction and unbiased criteria for cluster identification. The proposed method can be successfully used in both off-line data analysis and multidetector stability control.

Published
2001
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9. Intra-operative ultrasound of brain and spinal cord lesions

Author

M. Milazzotto, G. Guizzardi, M. Bartolucci, P. Innocenti, M. Cellerini, and P. Mennonna

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Ultrasound, Surgical procedures, Spinal cord, Surgery, medicine.anatomical_structure, Intra operative ultrasound, Medicine, Radiology, Nuclear Medicine and imaging, Neurosurgery, Radiology, business, Reduction (orthopedic surgery)
Abstract

Purpose To assess the role and to analyse the time required to perform intra-operative ultrasound (IUS) in neurosurgery. Methods Thirty-two patients with intracranial and spinal cord lesions underwent IUS with a standard, b-mode linear scanner. Results Intra-operative ultrasound resulted in reduction of the amount of potential damage to normal nervous tissues. In four patients, IUS played a fundamental role in the decision to enlarge the surgical exposure before opening the dura. The average length of time spent by the radiologist in the operating room was 1.45h in spinal cases and 1.15h in intracranial cases. Performance and interpretation of the IUS examination generally required one-fifth of the overall time spent by the radiologist in the operating room. Conclusions Intra-operative ultrasound is an easily available tool making the surgical procedures more accurate, even with standard equipment. However, it is both an operator-dependent and a time-consuming activity for the radiologist, and it would be useful for neurosurgeons to be trained to perform it.

Published
2001
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10. The enhanced data acquisition system for the 4/spl pi/ detector CHIMERA

Author

S. Pirrone, A. Anzalone, M. Bartolucci, M. L. Sperduto, R. Papa, S. Sambataro, G.R. Sechi, M. Geraci, G. Manfredi, Monica Alderighi, G. Lanzano, S. Femino, L. Zetta, F. Porto, G. Cardella, F. Giustolisi, S. Cavallaro, M. G. Campisi, A. Greco, C.M.I. Manno, Salvatore Lo Nigro, Sebastiano Aiello, E. Geraci, C. M. Sutera, G. Lanzalone, E. De Filippo, G. Politi, A. Pagano, and P. Guazzoni

Subjects
Nuclear and High Energy Physics, Engineering, business.industry, Detector, Data link, Data acquisition, Nuclear Energy and Engineering, Control system, Transfer (computing), Nuclear electronics, Central processing unit, Electrical and Electronic Engineering, business, Computer hardware, VMEbus
Abstract

CHIMERA is a second generation 4/spl pi/ detector for high resolution light particle and fragment measurements in the field of intermediate energy nuclear reactions. An enhanced data acquisition, control and trigger system has been developed to manage the almost 5000 electronic channels of the detector. The data acquisition system is based on a Fast Data Link (FDL) connection between 9U VME crates. The FDL is a highly programmable VME device. It performs data readout and transfer to a destination VME CPU, the FIC8243, running the real time OS9 operating system. Data read and transfer is performed by a fast protocol (Sparse Data Scan) whose performances have been improved introducing the Chained Block Transfer mode (CBLT) technique. Data collected by the CPU are broadcast to analysis work-stations for on-line data analysis and storage. All commands from and to the VME CPU are sent by socket-based network protocols. Complete remote control of the electronic front-end is obtained by a system of client-server applications. A first level event selection and control during readout is made by a trigger system based on a new VME 9U board (MUSE), fully integrated with the FDL readout system.

Published
2000
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11. The on-line computational and control system for the 4/spl pi/-detector CHIMERA

Author

D. Salvadori, G. Lanzano, G. Manfredi, S. Cavallaro, L. Zetta, G. Lanzalone, S. Pirrone, M. L. Sperduto, F. Giustolisi, G. Politi, Monica Alderighi, G. Cardella, E. Geraci, E. De Filippo, C. M. Sutera, Sebastiano Aiello, A. Anzalone, M. Bartolucci, G.R. Sechi, S. LoNigro, S. Femino, M. Papa, F. Porto, M. Geraci, A. Greco, A. Pagano, P. Guazzoni, C. M. Iacono-Manno, and S. Sambataro

Subjects
Ethernet, Nuclear and High Energy Physics, Windows NT, Computer science, business.industry, Interface (computing), Local area network, Electrical engineering, Pentium, Data acquisition, Software, Nuclear Energy and Engineering, Electrical and Electronic Engineering, business, Host (network), Computer hardware
Abstract

A commercial two-DSP-based board is the basic unit of the on-line computational and control system under development for the multidetector array CHIMERA. The system design includes a small scale parallel and distributed architecture of PCs and DSP boards. The PCs are used both as host computer and interface between user and network. Each PC can host up to three DSP boards. The system is able to accomplish the on-beam control of CHIMERA, by means of the on-line computation of special algorithms, instead of using the usual techniques of special pulses to be sent off-beam. The physical data, collected and organized in UDP packets by the data acquisition system, are read through a 10 Mbit/s Ethernet network. The PC software, running under Windows NT 4.0, is based on threads and assures the communication and program managing as well as the result presentation. The DSP-software is written in C++ and takes care of the communication with the PC and of the computation of algorithms. The preliminary on beam results for the first three wheels (about 100 telescopes), obtained by employing two biprocessor boards located in the PCI bus of a Pentium MMX PC, are also presented.

Published
2000
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12. Identification of 8Be isotopes in the CsI of CHIMERA detector

Author

W. Zipper, J. Blicharska, A. Grzeszczuk, M. Krauze, A. Stasz, M. Alderighi, A. Anzalone, L. Auditore, R. Barnà, V. Baran, I. Berceanu, M. Bartolucci, A. Bonasera, B. Borderie, R. Bougault, M. Bruno, J. Brzychczyk, G. Cardella, S. Cavallaro, A. Chbihi, M. Colonna, M. D’Agostino, R. Dayras, E. De Filippo, D. De Pasquale, M. Di Toro, W. Gawlikowicz, E. Geraci, F. Giustolisi, P. Guazzoni, D. Guinet, M. Iacono Manno, S. Kowalski, A. Italiano, E. La Guidara, G. Lanzanò, G. Lanzalone, N. Le Neindre, S. Li, S. Lo Nigro, C. Maiolino, Z. Majka, G. Manfredi, A. Pagano, M. Papa, M. Petrovici, E. Piasecki, S. Pirrone, R. Płaneta, G. Politi, A. Pop, F. Porto, M. F. Rivet, F. Rizzo, R. Russo, P. Russotto, K. Schmidt, G. Sechi, V. Simion, M. L. Sperduto, J. C. Steckmeyer, A. Trifirò, M. Trimarchi, G. Vannini, J. P. Wieleczko, J. Wilczynski, H. Wu, X. Ziao, L. Zetta, ROSATO, ELIO, VIGILANTE, MARIANO, R.Bougault, A.Pagano, S.Pirrone, M.F.Rivet e F.Rizzo, W., Zipper, J., Blicharska, A., Grzeszczuk, M., Krauze, A., Stasz, M., Alderighi, A., Anzalone, L., Auditore, R., Barnà, V., Baran, I., Berceanu, M., Bartolucci, A., Bonasera, B., Borderie, R., Bougault, M., Bruno, J., Brzychczyk, G., Cardella, S., Cavallaro, A., Chbihi, M., Colonna, M., D’Agostino, R., Dayra, E., De Filippo, D., De Pasquale, M., Di Toro, W., Gawlikowicz, E., Geraci, F., Giustolisi, P., Guazzoni, D., Guinet, M., Iacono Manno, S., Kowalski, A., Italiano, E., La Guidara, G., Lanzanò, G., Lanzalone, N., Le Neindre, S., Li, S., Lo Nigro, C., Maiolino, Z., Majka, G., Manfredi, A., Pagano, M., Papa, M., Petrovici, E., Piasecki, S., Pirrone, R., Płaneta, G., Politi, A., Pop, F., Porto, M. F., Rivet, F., Rizzo, Rosato, Elio, R., Russo, P., Russotto, K., Schmidt, G., Sechi, V., Simion, M. L., Sperduto, J. C., Steckmeyer, A., Trifirò, M., Trimarchi, G., Vannini, Vigilante, Mariano, J. P., Wieleczko, J., Wilczynski, H., Wu, X., Ziao, and L., Zetta

Published
2006

13. Comparing different architectures for real-time computing of special algorithms: A case study

Author

Stefano Feminò, Maria Leda Sperduto, S. Pirrone, Mario Geraci, G. Lanzalone, Luisa Zetta, A. Anzalone, G. Cardella, Sebastiano Aiello, F. Rizzo, F. Porto, P. Guazzoni, Giuseppe Politi, G. Manfredi, G.R. Sechi, Concetta Sutera, Salvatore Lo Nigro, M. Bartolucci, Carmelo Marcello Iacono-Manno, G. Lanzano, Angelo Pagano, S. Cavallaro, Enrico De Filippo, M. Papa, F. Giustolisi, and Salvatore Sambataro

Subjects
Artificial Intelligence, Computer Networks and Communications, Hardware and Architecture, Group method of data handling, Computer science, Computation, Work (physics), Real-time computing, Benchmark (computing), Nuclear Experiment, Algorithm, Software, Particle identification
Abstract

The on-line computation of special algorithms, such as those required for controlling multidetectors in heavy-ion nuclear physics experiments, is a fundamental problem. It requires real-time computational resources capable of satisfying the associated time constraints. The work presented describes general considerations on real-time architectures, and tests performed employing, as a benchmark, the computation of a power law, used for particle identification in nuclear physics experiments.

Published
1998
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14. Data acquisition and real-time computing by a DSP-based system

Author

E. DeFilippo, G. Cardella, S. Pirrone, M. Bartolucci, L. Sperduto, C. Sutera, Angelo Pagano, G. Lanzalone, M. Geraci, P. Guazzoni, F. Porto, F. Giustolisi, G. Lanzano, S. Femino, M. Iacono Manno, A. Anzalone, M. Papa, G. Politi, S. Cavallaro, L. Zetta, S. Lo Nigro, Sebastiano Aiello, F. Rizzo, G. Manfredi, and S. Sambataro

Subjects
Nuclear and High Energy Physics, Digital signal processor, Data processing, business.industry, Computer science, Interface (computing), Converters, Programmable logic device, Data acquisition, Table (database), business, Instrumentation, Digital signal processing, Computer hardware
Abstract

A digital signal processor (DSP) based two-parameter data acquisition system, connected to two analog-to-digital converters (ADCs) by means of an ad hoc built interface, was developed in order to perform real-time, on-line data processing. The interface, realized with programmable logic devices (PLD); may also work as a table of pre-computed values through which it is possible to carry out a simple analysis on the incoming or outcoming data.

Published
1998
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15. Isotope correlations as a freeze-out probe: central 124Sn+64Ni, 112Sn+58Ni collisions

Author

E. GERACI, M. BRUNO, M. D'AGOSTINO, E. DE FILIPPO, G. VANNINI, M. ALDERIGHI, A. ANZALONE, V. BARAN, R. BARN, M. BARTOLUCCI, I. BERCEANU, J. BLICHARSKA, J. BRZYCHCZYK, A. BONASERA, B. BORDERIE, R. BOUGAULT, G. CARDELLA, S. CAVALLARO, A. CHBIHI, J. CIBOR, M. COLONNA, R. DAYRAS, D. DE PASQUALE, M. DI TORO, F. GIUSTOLISI, A. GRZESZCZUK, P. GUAZZONI, D. GUI NET, M. IACONO MANNO, A. ITALIANO, S. KOWALSKI, E. LA GUIDARA, G. LANZALONE, G. LANZAN, N. LE NEINDRE, S. LI, S. LO NI GRO, C. MAIOLINO, Z. MAJKA, G. MANFREDI, T. PADUSZYNSKI, A. PAGANO, M. PAPA, C. M. PETROVICI, E. PIASECKI, S. PIRRONE, G. POLITI, A. POP, F. PORTO, M. F. RIVET, S. RUSSO, S. SAMBATARO, G. SECHI, V. SIMION, M. L. SPERDUTO, J. C. STECKMEYER C. SUTERA, A. TRI FIR, M. TRIMARCHI, J. P. WIELECZKO, J. WILCZYNSKI, H. WU, Z. XIAO, L. ZETTA E. W. ZIPPER, ROSATO, ELIO, VIGILANTE, MARIANO, E., Geraci, M., Bruno, M., D'Agostino, E., DE FILIPPO, G., Vannini, M., Alderighi, A., Anzalone, V., Baran, R., Barn, M., Bartolucci, I., Berceanu, J., Blicharska, J., Brzychczyk, A., Bonasera, B., Borderie, R., Bougault, G., Cardella, S., Cavallaro, A., Chbihi, J., Cibor, M., Colonna, R., Dayra, D., DE PASQUALE, M., DI TORO, F., Giustolisi, A., Grzeszczuk, P., Guazzoni, D., GUI NET, M., IACONO MANNO, A., Italiano, S., Kowalski, E., LA GUIDARA, G., Lanzalone, G., Lanzan, N., LE NEINDRE, S., Li, S., LO NI GRO, C., Maiolino, Z., Majka, G., Manfredi, T., Paduszynski, A., Pagano, M., Papa, C. M., Petrovici, E., Piasecki, S., Pirrone, G., Politi, A., Pop, F., Porto, M. F., Rivet, Rosato, Elio, S., Russo, S., Sambataro, G., Sechi, V., Simion, M. L., Sperduto, J. C. STECKMEYER C., Sutera, A., TRI FIR, M., Trimarchi, Vigilante, Mariano, J. P., Wieleczko, J., Wilczynski, H., Wu, Z., Xiao, and L. ZETTA E. W., Zipper

Published
2004

16. Isoscaling in central 124Sn+64Ni, 112Sn+58Ni collisions

Author

E. GERACI, M. BRUNO, M. D'AGOSTINO, E. DE FILIPPO, A. PAGANO, G. VANNINI, M. ALDERIGHI, A. ANZALONE, V. BARAN, R. BARN, M. BARTOLUCCI, I. BERCEANU, J. BLICHARSKA, A. BONASERA, B. BORDERIE, R. BOUGAULT, J. BRZYCHCZYK, G. CARDELLA, S. CAVALLA RO, A. CHBIHI, J. CIBOR, M. COLONNA, D. DE PASQUALE, M. DI TORO, F. GIUSTOLISI, A. GRZESZCZUK, P. GUAZZONI, D. GUINET, M. IA CONO MANNO, A. ITALIANO, S. KOWALSKI, E. LA GUIDARA, G. LANZALONE, G. LANZAN, N. LE NEINDRE, S. LI, S. LO NI GRO, C. MAIOLI NO, Z. MAJKA, G. MANFREDI, T. PADUSZYNSKI, M. PAPA, C. M. PETROVICI, E. PIASECKI, S. PIRRONE, G. POLITI, A. POP, F. PORTO, M. F. RIVET, S. RUSSO, P. RUSSOTTO, G. SECHI, V. SIMION, M. L. SPERDUTO, J. C. STECKMEYER, A. TRIFIR, M. TRIMARCHI, J. P. WIELECZKO, J. WILCZYNSKI, H. WU, Z. XIAO, L. ZETTA E. W. ZIPPER, ROSATO, ELIO, VIGILANTE, MARIANO, E., Geraci, M., Bruno, M., D'Agostino, E., DE FILIPPO, A., Pagano, G., Vannini, M., Alderighi, A., Anzalone, V., Baran, R., Barn, M., Bartolucci, I., Berceanu, J., Blicharska, A., Bonasera, B., Borderie, R., Bougault, J., Brzychczyk, G., Cardella, S., CAVALLA RO, A., Chbihi, J., Cibor, M., Colonna, D., DE PASQUALE, M., DI TORO, F., Giustolisi, A., Grzeszczuk, P., Guazzoni, D., Guinet, M., IA CONO MANNO, A., Italiano, S., Kowalski, E., LA GUIDARA, G., Lanzalone, G., Lanzan, N., LE NEINDRE, S., Li, S., LO NI GRO, C., MAIOLI NO, Z., Majka, G., Manfredi, T., Paduszynski, M., Papa, C. M., Petrovici, E., Piasecki, S., Pirrone, G., Politi, A., Pop, F., Porto, M. F., Rivet, Rosato, Elio, S., Russo, P., Russotto, G., Sechi, V., Simion, M. L., Sperduto, J. C., Steckmeyer, A., Trifir, M., Trimarchi, Vigilante, Mariano, J. P., Wieleczko, J., Wilczynski, H., Wu, Z., Xiao, and L. ZETTA E. W., Zipper

Published
2004

17. Fragmentation studies with the CHIMERA detector at LNS Catania: recent progress

Author

A. PAGANO, M. ALDERIGHI, F. AMORINI, A. ANZALONE, N. ARENA, L. AUDITORE, V. BARAN, M. BARTOLUCCI, I. BERCEANU, J. BLICHARSKA, J. BRZYCHCZYK, A. BONASERA, B. BORDERIE, R. BOUGAULT, M. BRUNO, G. CARDELLA, S. CAVALLARO, M. B. CHATTERJEE, A. CHBIHI, J. CIBOR, M. COLONNA, M. D'AGOSTINO, R. DAYRAS, E. DE FILIPPO, M. DI TORO, W. GAWLIKOWICZ, E. GERACI, F. GIUSTOLISI, A. GRZESZCZUK, P. GUAZZONI, D. GUINET, M. IACONO MANNO, S. KOWALSKI, E. LA GUIDARA, G. LANZALONE, G. LANZAN, N. LE NEINDRE, S. LI, S. LO NI GRO, C. MAIOLINO, Z. MAJKA, G. MANFREDI, T. PADUSZYNSKI, M. PAPA, C. M. PETROVICI, E. PIASECKI, S. PIRRONE, R. PLANETA, G. POLITI, A. POP, F. PORTO, M. F. RIVET, F. RIZZO, S. RUSSO, P. RUSSOTTO, M. SASSI, G. SECHI, V. SIMION, K. SIWEK WILCZYNSKA, I. SKWIRA, M. L. SPERDUTO, J. C. STECKMEYER L. SWIDERSKI, A. TRIFIR, M. TRIMARCHI, G. VANNINI, J. P. WIELECZKO, J. WILCZYNSKI, H. WU, Z. XIAO, L. ZETTA E. W. ZIPPER, ROSATO, ELIO, VIGILANTE, MARIANO, A., Pagano, M., Alderighi, F., Amorini, A., Anzalone, N., Arena, L., Auditore, V., Baran, M., Bartolucci, I., Berceanu, J., Blicharska, J., Brzychczyk, A., Bonasera, B., Borderie, R., Bougault, M., Bruno, G., Cardella, S., Cavallaro, M. B., Chatterjee, A., Chbihi, J., Cibor, M., Colonna, M., D'Agostino, R., Dayra, E., DE FILIPPO, M., DI TORO, W., Gawlikowicz, E., Geraci, F., Giustolisi, A., Grzeszczuk, P., Guazzoni, D., Guinet, M., IACONO MANNO, S., Kowalski, E., LA GUIDARA, G., Lanzalone, G., Lanzan, N., LE NEINDRE, S., Li, S., LO NI GRO, C., Maiolino, Z., Majka, G., Manfredi, T., Paduszynski, M., Papa, C. M., Petrovici, E., Piasecki, S., Pirrone, R., Planeta, G., Politi, A., Pop, F., Porto, M. F., Rivet, F., Rizzo, Rosato, Elio, S., Russo, P., Russotto, M., Sassi, G., Sechi, V., Simion, K., SIWEK WILCZYNSKA, I., Skwira, M. L., Sperduto, J. C. STECKMEYER L., Swiderski, A., Trifir, M., Trimarchi, G., Vannini, Vigilante, Mariano, J. P., Wieleczko, J., Wilczynski, H., Wu, Z., Xiao, and L. ZETTA E. W., Zipper

Published
2004

18. Isoscaling in central $^{124]$Sn + $^{64}$Ni, $^{112}$Sn + $^{58}$Ni collisions at 35 A MeV

Author

A. Chbihi, J.C. Steckmeyer, M. Iacono-Manno, A. Italiano, J. Brzychczyk, S. Kowalski, E. La Guidara, V. Baran, E. Piasecki, M. Papa, G. Vannini, L. Zetta, F. Giustolisi, D. Guinet, Z. Majka, S. Lo Nigro, R. Barnà, J. Cibor, M. Trimarchi, M.F. Rivet, Maria Colonna, S. M. Li, Antonio Trifiro, Amalia Pop, Mariano Vigilante, M. Di Toro, C. Maiolino, G. Lanzanó, P. Guazzoni, R. Bougault, M. Petrovici, D. De Pasquale, F. Porto, Angelo Pagano, S. Cavallaro, A. Bonasera, M. Bartolucci, A. Grzeszczuk, S. Russo, L. Auditore, G. Cardella, S. Pirrone, W. Zipper, N. Le Neindre, M. L. Sperduto, E. Geraci, Bernard Borderie, G. Lanzalone, G. Manfredi, M. D'Agostino, P. Russotto, M. Alderighi, Zhigang Xiao, H. Wu, A. Anzalone, G. Politi, J.P. Wieleczko, M. Bruno, I. Berceanu, G.R. Sechi, V. Simion, Elio Rosato, E. De Filippo, J. Wilczynski, J. Blicharska, T. Paduszynski, Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Grand Accélérateur National d'Ions Lourds (GANIL), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), E. GERACI, M. ALDERIGHI, A. ANZALONE, L. AUDITORE, V. BARAN, R. BARNA', M. BARTOLUCCI, I. BERCEANU, J. BLICHARSKA, A. BONASERA, B. BORDERIE, R. BOUGAULT, BRUNO M., J. BRZYCHCZYK, G. CARDELLA, S. CAVALLARO, A. CHBIHI, J. CIBOR, M. COLONNA, M. D'AGOSTINO, E .DE FILIPPO, D. DE PASQUALE, M. DI TORO, F. GIUSTOLISI, A. GRZESZCZUK, P. GUAZZONI, D. GUINET, M. IACONO-MANNO, A. ITALIANO, S. KOWALSKI, E. LA GUIDARA, G. LANZALONE, G. LANZANO', N. LE NEINDRE, S. LI, S. LO NIGRO, C. MAIOLINO, Z. MAJKA, G. MANFREDI, T. PADUSZYNSKI, A. PAGANO, M. PAPA, M. PETROVICI, E. PIASECKI, S. PIRRONE, G. POLITI, A. POP, F. PORTO, M. F. RIVET, E. ROSATO, S. RUSSO, P. RUSSOTTO, G. SECHI, V. SIMION, M. L. SPERDUTO, J. C. STECKMEYER, A. TRIFIRO, M. TRIMARCHI, G. VANNINI, M. VIGILANTE, J. P. WIELECZKO, J. WILCZYNSKI, H. WU, Z. XIAO, L. ZETTA, W. ZIPPER, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Nuclear reaction, Nuclear and High Energy Physics, Phase transition, Heavy ion–nucleus reactions, Nuclear isospin, Nuclear fragmentation, MATERIA NUCLEARE, Nuclear Theory, Hadron, 112Sn(58Ni, FRAMMENTAZIONE NUCLEARE, ISOSPIN, REAZIONI NUCLEARI FRA IONI PESANTI, ISOTOPI, Elementary particle, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, 7. Clean energy, 25.70.-z, 25.70.Pq, 24.10.Pa, 02.50.Sk, 124Sn(64Ni, Isotopes, 0103 physical sciences, Neutron, Nuclear Experiment, 010306 general physics, Nuclear matter, X), Physics, 010308 nuclear & particles physics, Baryon, Isospin, E=35 A MeV, Nuclear reactions, Atomic physics, Nucleon
Abstract

124 Sn+ 64 Ni and 112 Sn+ 58 Ni reactions at 35 A MeV incident energy were studied by using the 688 Si–CsI telescopes of the forward part (1°⩽ θ lab ⩽30°) of CHIMERA multi-detector. The most central part, 1% of the total measured cross section was selected by means of a multidimensional analysis of the experimental observables. The detected isotopes of light fragments (3⩽ Z ⩽8) provided information on breakup temperatures of the emitting sources. The space–time structure of these sources was deduced from fragment correlations. An odd–even effect in the fragment production, enhanced by the isospin of the entrance channel, was observed. Freeze-out unbound neutron-to-proton relative densities for both studied reactions have been deduced, indicating for a possible isospin distillation mechanism related to a phenomenon of the liquid–gas phase transition in asymmetric systems.

Published
2004
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19. La RM nelle sequele dei traumi spinali

Author

M. D'Andrea, M. Bartolucci, M. Mizzau, G. Caracchini, G. Dal Pozzo, G. Pellicanò, I. Del Seppia, and M. Cellerini

Subjects
medicine.medical_specialty, Radiological and Ultrasound Technology, Medullary cavity, business.industry, Sequela, medicine.disease, Spinal cord, 030218 nuclear medicine & medical imaging, Surgery, Lesion, 03 medical and health sciences, 0302 clinical medicine, Atrophy, medicine.anatomical_structure, medicine, Radiology, Nuclear Medicine and imaging, Syrinx (medicine), Neurology (clinical), Radiology, medicine.symptom, business, Myelomalacia, 030217 neurology & neurosurgery, Syringomyelia
Abstract

From January 1990 to April 1997 we retrospectively evaluated 90 patients with MR examinations at our Spine Unit. The following post-traumatic spinal cord lesions were diagnosed: atrophy (47 pts), myelomalacia (40 pts), cysts (14), syrinx (14) and medullary transection with adhesion(4 pts). MR was very useful to identify atrophy more frequently found at the cervical-thoracic level (C6-D3). Myelomalcia was found in a patient with severe vertebral body trauma with chronic compression of the spinal cord. Intramedullary cysts were found in patients with hematomyelia in acute phase and were stable lesions. Post-traumatic syringomyelia is the most important sequela due to the fact that is often correlated with symptoms. MR not only detected the lesion but also identified intramedullary cavities without new neurological symptoms and guided surgery and follow-up. MR is the examination of choice not only for diagnosis of chronic spinal cord lesions but also to evaluate the possibility of surgical treatment.

Published
1997
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20. Computation of numerical algorithms with parametric floating point operators

Author

Luisa Zetta, M. Bartolucci, P. Guazzoni, G.R. Sechi, and G. Manfredi

Subjects
Polynomial, Significand, Mathematical optimization, Correctness, Floating point, Hardware and Architecture, Computer science, Computation, Limit (mathematics), Symbolic computation, Polynomial expansion, Algorithm, Software
Abstract

The computation complexity of a large number of applications, makes useful the development of new design strategies both in the direction of correctness and reduction of computational time and size of the used devices. Since a large part of numerical algorithms involves the computation of polynomial expansions in terms of sum and products of floating point numbers, a way for reducing both dimension and execution time of the devices, is to adapt the elementary operators and the number of terms of the polynomial expansion to the very computational needs. In this work a design method consisting in using an ad hoc designed set of Elementary Floating Point Operators parametrically defined is presented. Moreover, we discuss the mantissa size influence on real-time computation of numerical algorithms, in order to state the truncation limit for which the correctness constraints are anyhow saved for different applications in order to allow a more reliable choice of the hardware, and to limit also the general costs.

Published
1997
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21. Isotope correlations as a probe for freeze-out charaterization: central $^{124}$Sn+$^{64}$Ni, $^{112}$Sn+$^{58}$Ni collisions

Author

S. Pirrone, M. L. Sperduto, Bernard Borderie, Monica Alderighi, M. Di Toro, J. Brzychczyk, P. Russotto, L. Zetta, Z. Majka, S. Lo Nigro, F. Porto, S. Kowalski, Maria Colonna, M. Bartolucci, A. Anzalone, Angelo Pagano, M. Papa, G. Vannini, S. Russo, Amalia Pop, S. Cavallaro, J. Wilczynski, G.R. Sechi, V. Simion, T. Paduszynski, A. Chbihi, D. Guinet, J. Blicharska, J.C. Steckmeyer, E. Piasecki, M. Bruno, G. Cardella, M.F. Rivet, M. Iacono-Manno, Elio Rosato, E. De Filippo, G. Lanzalone, F. Giustolisi, Marina Trimarchi, G. Manfredi, Antonio Trifiro, E. Geraci, P. Guazzoni, Zhigang Xiao, H. Wu, I. Berceanu, Mariano Vigilante, A. Grzeszczuk, G. Lanzanó, R. Bougault, V. Baran, S. M. Li, E. La Guidara, M. Petrovici, J. Cibor, A. Bonasera, W. Zipper, N. Le Neindre, J.P. Wieleczko, C. Maiolino, M. D'Agostino, Lucrezia Auditore, G. Politi, Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Grand Accélérateur National d'Ions Lourds (GANIL), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), E. GERACI, M. ALDERIGHI, A. ANZALONE, L. AUDITORE, V. BARAN, M. BARTOLUCCI, I. BERCEANU, J. BLICHARSKA, A. BONASERA, B. BORDERIE, R. BOUGAULT, BRUNO M., J. BRZYCHCZYK, G. CARDELLA, S. CAVALLARO, A. CHBIHI, J. CIBOR, M. COLONNA, M. D'AGOSTINO, E .DE FILIPPO, M. DI TORO, F. GIUSTOLISI, A. GRZESZCZUK, P. GUAZZONI, D. GUINET, M. IACONO-MANNO, S. KOWALSKI, E. LA GUIDARA, G. LANZALONE, G. LANZANO', N. LE NEINDRE, S. LI, S. LO NIGRO, C. MAIOLINO, Z. MAJKA, G. MANFREDI, T. PADUSZYNSKI, A. PAGANO, M. PAPA, M. PETROVICI, E. PIASECKI, S. PIRRONE, G. POLITI, A. POP, F. PORTO, M. F. RIVET, E. ROSATO, S. RUSSO, P. RUSSOTTO, G. SECHI, V. SIMION, M. L. SPERDUTO, J. C. STECKMEYER, A. TRIFIRO, M. TRIMARCHI, G. VANNINI, M. VIGILANTE, J. P. WIELECZKO, J. WILCZYNSKI, H. WU, Z. XIAO, L. ZETTA, W. ZIPPER, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Nuclear reaction, RAPPORTO FRA DENSITA’ FRA NEUTRONI E PROTONI, Nuclear and High Energy Physics, TEMPERATURA E VOLUME DELLA SORGENTE, Proton, FOS: Physical sciences, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 7. Clean energy, 01 natural sciences, SORGENTE ECCITATA, 0103 physical sciences, Incident energy, Neutron, Nuclear Experiment (nucl-ex), 010306 general physics, Nuclear Experiment, DIMENSIONE, Physics, Isotope, 010308 nuclear & particles physics, REAZIONI NUCLEARI CENTRALI, RESE DI ISOTOPI, Characterization (materials science), Volume (thermodynamics), Yield (chemistry), Atomic physics
Abstract

124Sn+64Ni and 112Sn+58Ni reactions at 35 AMeV incident energy were studied with the forward part of CHIMERA multi-detector. The most central collisions were selected by means of a multidimensional analysis. The characteristics of the source formed in the central collisions, as size, temperature and volume, were inspected. The measured isotopes of light fragments (3, 4 pages, Contribution to 8th International Conference on Nucleus-Nucleus Collisions, Moscow 2003

Published
2003

22. Dynamical aspects of fragment productions in the reactions 124Sn+64Ni and 112Sn+58Ni at 35 A.Mev

Author

E. DE FILLIPPO, M. ALDERIGHI, F. AMORINI, A. ANZALONE, N. ARENA, L. AUDITORE, V. BARAN, M. BARTOLUCCI, I. BERCEANU, J. BLICHARSKA, J. BRZYCHCZYK, A. BONASERA, B. BORDERIE, R. BOUGAULT, M. BRUNO, G. CARDELLA, S. CAVALLARO, M. B. CHATTERJEE, A. CHBIHI, J. CIBOR, M. COLONNA, M. D'AGOSTINO, R. DAYRAS, M. DI TORO, W. GAWLIKOWICZ, E. GERACI, F. GIUSTOLISI, A. GRZESZCZUK, P. GUAZZONI, D. GUINET, M. IACONO MANNO, S. KOWALSKI, E. LA GUIDARA, G. LANZAN, G. LANZALONE, N. LE NEINDRE, S. LI, S. LO NIGRO, C. MAIOLINO, Z. MAJKA, G. MANFREDI, T. PADUSZYNSKI, A. PAGANO, M. PAPA, C. M. PETROVICI, E. PIASECKI, S. PIRRONE, R. PLANETA, G. POLITI, A. POP, F. PORTO, M. F. RIVET, F. RIZZO, S. RUSSO, P. RUSSOTTO, K. SCHMIDT, G. SECHI, V. SIMION, K. SIWEK WILCZYNSKA, I. SKWIRA, M. L. SPERDUTO, J. C. STECKMEYER, L. SWIDERSKI, A. TRIFIR, M. TRIMARCHI, G. VANNINI, J. P. WIELECZKO, J. WILCZYNSKI, H. WU, Z. XIAO, L. ZETTA, W. ZIPPER, ROSATO, ELIO, VIGILANTE, MARIANO, G.Agnello, A.Pagano, S.Pirrone, E., DE FILLIPPO, M., Alderighi, F., Amorini, A., Anzalone, N., Arena, L., Auditore, V., Baran, M., Bartolucci, I., Berceanu, J., Blicharska, J., Brzychczyk, A., Bonasera, B., Borderie, R., Bougault, M., Bruno, G., Cardella, S., Cavallaro, M. B., Chatterjee, A., Chbihi, J., Cibor, M., Colonna, M., D'Agostino, R., Dayra, M., DI TORO, W., Gawlikowicz, E., Geraci, F., Giustolisi, A., Grzeszczuk, P., Guazzoni, D., Guinet, M., IACONO MANNO, S., Kowalski, E., LA GUIDARA, G., Lanzan, G., Lanzalone, N., LE NEINDRE, S., Li, S., LO NIGRO, C., Maiolino, Z., Majka, G., Manfredi, T., Paduszynski, A., Pagano, M., Papa, C. M., Petrovici, E., Piasecki, S., Pirrone, R., Planeta, G., Politi, A., Pop, F., Porto, M. F., Rivet, Rosato, Elio, F., Rizzo, S., Russo, P., Russotto, K., Schmidt, G., Sechi, V., Simion, K., SIWEK WILCZYNSKA, I., Skwira, M. L., Sperduto, J. C., Steckmeyer, L., Swiderski, A., Trifir, M., Trimarchi, G., Vannini, Vigilante, Mariano, J. P., Wieleczko, J., Wilczynski, H., Wu, Z., Xiao, and L. ZETTA, W. ZIPPER

Published
2003

23. Global results of the REVERSE experiment

Author

E. DE FILLIPPO, S. AIELLO, M. ALDERIGHI, A. ANZALONE, M. BALDO, R. BARN, M. BARTOLUCCI, I. BERCEANU, A. BONASERA, B. BORDERIE, A. BOTVINA, R. BOUGAULT, M. BRUNO, G. CARDELLA, S. CAVALLARO, M. COLONNA, M. D'AGOSTINO, E. D'AMICO, R. DAYRAS, N. DE CESARE, D. DE PASQUALE, M. DI TORO, S. FEMIN, E. FUSCHINI, E. GERACI, F. GIUSTOLISI, A. GRZESZCZUK, P. GUAZZONI, D. GUINET, M. IACONO MANNO, A. ITALIANO, S. KOWALSKI, G. LANZAN, G. LANZALONE, N. LE NEINDRE, S. LI, U. LOMBARDO, S. LO NIGRO, C. MAIOLINO, D. MAHBOUB, G. MANFREDI, G. MARGAGLIOTTI, D. MOISA, T. PADUSZYNSKI, A. PAGANO, M. PAPA, C. M. PETROVICI, E. PIASECKI, S. PIRRONE, G. POLITI, E. POLLACCO, A. POP, F. PORTO, A. RAPISARDA, M. F. RIVET, S. SAMBATARO, G. SECHI, V. SIMION, M. L. SPERDUTO, J. C. STECKMEYER, C. SUTERA, A. TRIFIR, M. TRIMARCHI, G. VANNINI, J. WILCZYNSKI, H. WU, Z. XIAO, L. ZETTA, W. ZIPPER, ROSATO, ELIO, VIGILANTE, MARIANO, G.Agnello, A.Pagano, S.Pirrone, E., DE FILLIPPO, S., Aiello, M., Alderighi, A., Anzalone, M., Baldo, R., Barn, M., Bartolucci, I., Berceanu, A., Bonasera, B., Borderie, A., Botvina, R., Bougault, M., Bruno, G., Cardella, S., Cavallaro, M., Colonna, M., D'Agostino, E., D'Amico, R., Dayra, N., DE CESARE, D., DE PASQUALE, M., DI TORO, S., Femin, E., Fuschini, E., Geraci, F., Giustolisi, A., Grzeszczuk, P., Guazzoni, D., Guinet, M., IACONO MANNO, A., Italiano, S., Kowalski, G., Lanzan, G., Lanzalone, N., LE NEINDRE, S., Li, U., Lombardo, S., LO NIGRO, C., Maiolino, D., Mahboub, G., Manfredi, G., Margagliotti, D., Moisa, T., Paduszynski, A., Pagano, M., Papa, C. M., Petrovici, E., Piasecki, S., Pirrone, G., Politi, E., Pollacco, A., Pop, F., Porto, A., Rapisarda, M. F., Rivet, Rosato, Elio, S., Sambataro, G., Sechi, V., Simion, M. L., Sperduto, J. C., Steckmeyer, C., Sutera, A., Trifir, M., Trimarchi, G., Vannini, Vigilante, Mariano, J., Wilczynski, H., Wu, Z., Xiao, and L. ZETTA, W. ZIPPER

Abstract

iwm2001

Published
2002

24. First results on isotopic studies in multifragmentation obtained with the CHIMERA 4 multide-tector

Author

N. LE NEINDRE, S. AIELLO, M. ALDERIGHI, A. ANZALONE, M. BALDO, R. BARN, M. BARTOLUCCI, I. BERCEANU, A. BONASERA, B. BORDERIE, A. BOTVINA, R. BOUGAULT, M. BRUNO, G. CARDELLA, S. CAVALLARO, M. COLONNA, M. D'AGOSTINO, E. D'AMICO, R. DAYRAS, N. DE CESARE, E. DE FILLIPPO, D. DE PASQUALE, M. DI TORO, S. FEMIN, E. FUSCHINI, E. GERACI, F. GIUSTOLISI, A. GRZESZCZUK, P. GUAZZONI, D. GUINET, M. IACONO MANNO, A. ITALIANO, S. KOWALSKI, G. LANZAN, G. LANZALONE, S. LI, U. LOMBARDO, S. LO NIGRO, C. MAIOLINO, D. MAHBOUB, G. MANFREDI, G. MARGAGLIOTTI, D. MOISA, T. PADUSZYNSKI, A. PAGANO, M. PAPA, C. M. PETROVICI, E. PIASECKI, S. PIRRONE, G. POLITI, E. POLLACCO, A. POP, F. PORTO, A. RAPISARDA, M. F. RIVET, S. SAMBATARO, G. SECHI, V. SIMION, M. L. SPERDUTO, J. C. STECKMEYER, C. SUTERA, A. TRIFIR, M. TRIMARCHI, G. VANNINI, J. WILCZYNSKI, H. WU, Z. XIAO, L. ZETTA, W. ZIPPER, ROSATO, ELIO, VIGILANTE, MARIANO, G.Agnello, A.Pagano, S.Pirrone, N., LE NEINDRE, S., Aiello, M., Alderighi, A., Anzalone, M., Baldo, R., Barn, M., Bartolucci, I., Berceanu, A., Bonasera, B., Borderie, A., Botvina, R., Bougault, M., Bruno, G., Cardella, S., Cavallaro, M., Colonna, M., D'Agostino, E., D'Amico, R., Dayra, N., DE CESARE, E., DE FILLIPPO, D., DE PASQUALE, M., DI TORO, S., Femin, E., Fuschini, E., Geraci, F., Giustolisi, A., Grzeszczuk, P., Guazzoni, D., Guinet, M., IACONO MANNO, A., Italiano, S., Kowalski, G., Lanzan, G., Lanzalone, S., Li, U., Lombardo, S., LO NIGRO, C., Maiolino, D., Mahboub, G., Manfredi, G., Margagliotti, D., Moisa, T., Paduszynski, A., Pagano, M., Papa, C. M., Petrovici, E., Piasecki, S., Pirrone, G., Politi, E., Pollacco, A., Pop, F., Porto, A., Rapisarda, M. F., Rivet, Rosato, Elio, S., Sambataro, G., Sechi, V., Simion, M. L., Sperduto, J. C., Steckmeyer, C., Sutera, A., Trifir, M., Trimarchi, G., Vannini, Vigilante, Mariano, J., Wilczynski, H., Wu, Z., Xiao, and L. ZETTA, W. ZIPPER

Abstract

ibidem

Published
2002

25. Dynamical fission observed in 112,124Sn + 58,64Ni REVERSE experiment

Author

E. PIASECKI, S. AIELLO, M. ALDERIGHI, A. ANZALONE, M. BALDO, R. BARN, M. BARTOLUCCI, I. BERCEANU, A. BONASERA, B. BORDERIE, A. BOTVINA, R. BOUGAULT, M. BRUNO, G. CARDELLA, S. CAVALLARO, M. COLONNA, M. D'AGOSTINO, E. D'AMICO, R. DAYRAS, N. DE CESARE, E. DE FILLIPPO, D. DE PASQUALE, M. DI TORO, S. FEMIN, E. FUSCHINI, E. GERACI, F. GIUSTOLISI, A. GRZESZCZUK, P. GUAZZONI, D. GUINET, M. IACONO MANNO, A. ITALIANO, S. KOWALSKI, G. LANZAN, G. LANZALONE, N. LE NEINDRE, S. LI, U. LOMBARDO, S. LO NIGRO, C. MAIOLINO, D. MAHBOUB, G. MANFREDI, G. MARGAGLIOTTI, D. MOISA, T. PADUSZYNSKI, A. PAGANO, M. PAPA, C. M. PETROVICI, S. PIRRONE, G. POLITI, E. POLLACCO, A. POP, F. PORTO, A. RAPISARDA, M. F. RIVET, S. SAMBATARO, G. SECHI, V. SIMION, M. L. SPERDUTO, J. C. STECKMEYER, C. SUTERA, A. TRIFIR, M. TRIMARCHI, G. VANNINI, J. WILCZYNSKI, H. WU, Z. XIAO, L. ZETTA, W. ZIPPER, ROSATO, ELIO, VIGILANTE, MARIANO, G.Agnello, A.Pagano, S.Pirrone, E., Piasecki, S., Aiello, M., Alderighi, A., Anzalone, M., Baldo, R., Barn, M., Bartolucci, I., Berceanu, A., Bonasera, B., Borderie, A., Botvina, R., Bougault, M., Bruno, G., Cardella, S., Cavallaro, M., Colonna, M., D'Agostino, E., D'Amico, R., Dayra, N., DE CESARE, E., DE FILLIPPO, D., DE PASQUALE, M., DI TORO, S., Femin, E., Fuschini, E., Geraci, F., Giustolisi, A., Grzeszczuk, P., Guazzoni, D., Guinet, M., IACONO MANNO, A., Italiano, S., Kowalski, G., Lanzan, G., Lanzalone, N., LE NEINDRE, S., Li, U., Lombardo, S., LO NIGRO, C., Maiolino, D., Mahboub, G., Manfredi, G., Margagliotti, D., Moisa, T., Paduszynski, A., Pagano, M., Papa, C. M., Petrovici, S., Pirrone, G., Politi, E., Pollacco, A., Pop, F., Porto, A., Rapisarda, M. F., Rivet, Rosato, Elio, S., Sambataro, G., Sechi, V., Simion, M. L., Sperduto, J. C., Steckmeyer, C., Sutera, A., Trifir, M., Trimarchi, G., Vannini, Vigilante, Mariano, J., Wilczynski, H., Wu, Z., Xiao, and L. ZETTA, W. ZIPPER

Abstract

iwm2001

Published
2001

26. Isospin physics with the REVERSE experiment

Author

S. Pirrone, S. Aiello, M. Alderighi, A. Anzalone, M. Baldo, R. Barnà, M. Bartolucci, I. Berceanu, A. Bonasera, B. Borderie, A. Botvina, R. Bougault, M. Bruno, G. Cardella, S. Cavallaro, M. Colonna, M. D'Agostino, E. D'Amico, R. Dayras, N. De Cesare, E. De Fillippo, D. De Pasquale, M. Di Toro, S. Feminò, E. Fuschini, E. Geraci, F. Giustolisi, A. Grzeszczuk, P. Guazzoni, D. Guinet, M. Iacono Manno, A. Italiano, S. Kowalski, G. Lanzanò, G. Lanzalone, N. Le Neindre, S. Li, U. Lombardo, S. Lo Nigro, C. Maiolino, D. Mahboub, G. Manfredi, G. Margagliotti, D. Moisa, T. Paduszynski, A. Pagano, M. Papa, C. M. Petrovici, E. Piasecki, G. Politi, E. Pollacco, A. Pop, F. Porto, A. Rapisarda, M. F. Rivet, S. Sambataro, G. Sechi, V. Simion, M. L. Sperduto, J. C. Steckmeyer, C. Sutera, A. Trifirò, M. Trimarchi, G. Vannini, J. Wilczynski, H. Wu, Z. Xiao, L. Zetta, W. Zipper, ROSATO, ELIO, VIGILANTE, MARIANO, G.Fazio, G.Giardina, F.Hanappe, G.Immé, N.Rowley, S., Pirrone, S., Aiello, M., Alderighi, A., Anzalone, M., Baldo, R., Barnà, M., Bartolucci, I., Berceanu, A., Bonasera, B., Borderie, A., Botvina, R., Bougault, M., Bruno, G., Cardella, S., Cavallaro, M., Colonna, M., D'Agostino, E., D'Amico, R., Dayra, N., De Cesare, E., De Fillippo, D., De Pasquale, M., Di Toro, S., Feminò, E., Fuschini, E., Geraci, F., Giustolisi, A., Grzeszczuk, P., Guazzoni, D., Guinet, M., Iacono Manno, A., Italiano, S., Kowalski, G., Lanzanò, G., Lanzalone, N., Le Neindre, S., Li, U., Lombardo, S., Lo Nigro, C., Maiolino, D., Mahboub, G., Manfredi, G., Margagliotti, D., Moisa, T., Paduszynski, A., Pagano, M., Papa, C. M., Petrovici, E., Piasecki, G., Politi, E., Pollacco, A., Pop, F., Porto, A., Rapisarda, M. F., Rivet, Rosato, Elio, S., Sambataro, G., Sechi, V., Simion, M. L., Sperduto, J. C., Steckmeyer, C., Sutera, A., Trifirò, M., Trimarchi, G., Vannini, Vigilante, Mariano, J., Wilczynski, H., Wu, Z., Xiao, L., Zetta, and W., Zipper

Published
2001

27. Physics with the CHIMERA detector at LNS in Catania: the REVERSE experiment

Author

A. PAGANO, S. AIELLO, M. ALDERIGHI, A. ANZALONE, M. BALDO, R. BARN, M. BARTOLUCCI, I. BERCEANU, A. BONASERA, B. BORDERIE, A. BOTVINA, R. BOUGAULT, M. BRUNO, G. CARDELLA, S. CAVALLARO, M. COLONNA, M. D'AGOSTINO, E. D'AMICO, R. DAYRAS, N. DE CESARE, E. DE FILLIPPO, D. DE PASQUALE, M. DI TORO, S. FEMIN, E. FUSCHINI, E. GERACI, F. GIUSTOLISI, A. GRZESZCZUK, P. GUAZZONI, D. GUINET, M. IACONO MANNO, A. ITALIANO, S. KOWALSKI, G. LANZAN, G. LANZALONE, N. LE NEINDRE, S. LI, U. LOMBARDO, S. LO NIGRO, C. MAIOLINO, D. MAHBOUB, G. MANFREDI, G. MARGAGLIOTTI, D. MOISA, T. PADUSZYNSKI, M. PAPA, C. M. PETROVICI, E. PIASECKI, S. PIRRONE, G. POLITI, E. POLLACCO, A. POP, F. PORTO, A. RAPISARDA, M. F. RIVET, S. SAMBATARO, G. SECHI, V. SIMION, M. L. SPERDUTO, J. C. STECKMEYER, C. SUTERA, A. TRIFIR, M. TRIMARCHI, G. VANNINI, J. WILCZYNSKI, H. WU, Z. XIAO, L. ZETTA E. W. ZIPPER, ROSATO, ELIO, VIGILANTE, MARIANO, A., Pagano, S., Aiello, M., Alderighi, A., Anzalone, M., Baldo, R., Barn, M., Bartolucci, I., Berceanu, A., Bonasera, B., Borderie, A., Botvina, R., Bougault, M., Bruno, G., Cardella, S., Cavallaro, M., Colonna, M., D'Agostino, E., D'Amico, R., Dayra, N., DE CESARE, E., DE FILLIPPO, D., DE PASQUALE, M., DI TORO, S., Femin, E., Fuschini, E., Geraci, F., Giustolisi, A., Grzeszczuk, P., Guazzoni, D., Guinet, M., IACONO MANNO, A., Italiano, S., Kowalski, G., Lanzan, G., Lanzalone, N., LE NEINDRE, S., Li, U., Lombardo, S., LO NIGRO, C., Maiolino, D., Mahboub, G., Manfredi, G., Margagliotti, D., Moisa, T., Paduszynski, M., Papa, C. M., Petrovici, E., Piasecki, S., Pirrone, G., Politi, E., Pollacco, A., Pop, F., Porto, A., Rapisarda, M. F., Rivet, Rosato, Elio, S., Sambataro, G., Sechi, V., Simion, M. L., Sperduto, J. C., Steckmeyer, C., Sutera, A., Trifir, M., Trimarchi, G., Vannini, Vigilante, Mariano, J., Wilczynski, H., Wu, Z., Xiao, and L. ZETTA E. W., Zipper

Published
2001

28. REVERSE: the first experiment with the CHIMERA detector

Author

S. Aiello, M. Alderighi, A. Anzalone, M. Baldo, R. Barnà, M. Bartolucci, I. Berceanu, A. Bonasera, B. Borderie, A. Botvina, R. Bougault, M. Bruno, G. Cardella, S. Cavallaro, M. Colonna, M. D'Agostino, E. D'Amico, R. Dayras, N. De Cesare, E. De Fillippo, D. De Pasquale, M. Di Toro, S. Feminò, E. Fuschini, F. Giustolisi, A. Grzeszczuk, P. Guazzoni, D. Guinet, M. Iacono Manno, A. Italiano, S. Kowalski, G. Lanzanò, G. Lanzalone, N. Le Neindre, S. Li, U. Lombardo, S. Lo Nigro, C. Maiolino, D. Mahboub, G. Manfredi, G. Margagliotti, D. Moisa, T. Paduszynski, A. Pagano, M. Papa, C. M. Petrovici, E. Piasecki, S. Pirrone, G. Politi, E. Pollacco, A. Pop, F. Porto, A. Rapisarda, M. F. Rivet, S. Sambataro, G. Sechi, V. Simion, M. L. Sperduto, J. C. Steckmeyer, C. Sutera, A. Trifirò, M. Trimarchi, G. Vannini, J. Wilczynski, H. Wu, Z. Xiao, L. Zetta, W. Zippe, ROSATO, ELIO, VIGILANTE, MARIANO, G.C.Bonsignori, M.Bruno, A.Ventura, D.Vretenar, S., Aiello, M., Alderighi, A., Anzalone, M., Baldo, R., Barnà, M., Bartolucci, I., Berceanu, A., Bonasera, B., Borderie, A., Botvina, R., Bougault, M., Bruno, G., Cardella, S., Cavallaro, M., Colonna, M., D'Agostino, E., D'Amico, R., Dayra, N., De Cesare, E., De Fillippo, D., De Pasquale, M., Di Toro, S., Feminò, E., Fuschini, F., Giustolisi, A., Grzeszczuk, P., Guazzoni, D., Guinet, M., Iacono Manno, A., Italiano, S., Kowalski, G., Lanzanò, G., Lanzalone, N., Le Neindre, S., Li, U., Lombardo, S., Lo Nigro, C., Maiolino, D., Mahboub, G., Manfredi, G., Margagliotti, D., Moisa, T., Paduszynski, A., Pagano, M., Papa, C. M., Petrovici, E., Piasecki, S., Pirrone, G., Politi, E., Pollacco, A., Pop, F., Porto, A., Rapisarda, M. F., Rivet, Rosato, Elio, S., Sambataro, G., Sechi, V., Simion, M. L., Sperduto, J. C., Steckmeyer, C., Sutera, A., Trifirò, M., Trimarchi, G., Vannini, Vigilante, Mariano, J., Wilczynski, H., Wu, Z., Xiao, L., Zetta, and W., Zippe

Published
2001

29. REVERSE experiment at Laboratori Nazionali del Sud

Author

S. Aiello, M. Alderighi, A. Anzalone, M. Baldo, R. Barnà, M. Bartolucci, I. Berceanu, A. Bonasera, B. Borderie, A. Botvina, R. Bougault, M. Bruno, G. Cardella, S. Cavallaro, M. Colonna, M. D'Agostino, E. D'Amico, R. Dayras, N. De Cesare, E. De Fillippo, D. De Pasquale, M. Di Toro, S. Feminò, E. Fuschini, F. Giustolisi, A. Grzeszczuk, P. Guazzoni, D. Guinet, M. Iacono Manno, A. Italiano, S. Kowalski, G. Lanzanò, G. Lanzalone, N. Le Neindre, S. Li, U. Lombardo, S. Lo Nigro, C. Maiolino, D. Mahboub, G. Manfredi, G. Margagliotti, D. Moisa, T. Paduszynski, A. Pagano, M. Papa, C. M. Petrovici, E. Piasecki, S. Pirrone, G. Politi, E. Pollacco, A. Pop, F. Porto, A. Rapisarda, M. F. Rivet, S. Sambataro, G. Sechi, V. Simion, M. L. Sperduto, J. C. Steckmeyer, C. Sutera, A. Trifirò, M. Trimarchi, G. Vannini, J. Wilczynski, H. Wu, Z. Xiao, L. Zetta, W. Zipper, ROSATO, ELIO, VIGILANTE, MARIANO, G.C.Bonsignori, M.Bruno, A.Ventura, D.Vretenar, S., Aiello, M., Alderighi, A., Anzalone, M., Baldo, R., Barnà, M., Bartolucci, I., Berceanu, A., Bonasera, B., Borderie, A., Botvina, R., Bougault, M., Bruno, G., Cardella, S., Cavallaro, M., Colonna, M., D'Agostino, E., D'Amico, R., Dayra, N., De Cesare, E., De Fillippo, D., De Pasquale, M., Di Toro, S., Feminò, E., Fuschini, F., Giustolisi, A., Grzeszczuk, P., Guazzoni, D., Guinet, M., Iacono Manno, A., Italiano, S., Kowalski, G., Lanzanò, G., Lanzalone, N., Le Neindre, S., Li, U., Lombardo, S., Lo Nigro, C., Maiolino, D., Mahboub, G., Manfredi, G., Margagliotti, D., Moisa, T., Paduszynski, A., Pagano, M., Papa, C. M., Petrovici, E., Piasecki, S., Pirrone, G., Politi, E., Pollacco, A., Pop, F., Porto, A., Rapisarda, M. F., Rivet, Rosato, Elio, S., Sambataro, G., Sechi, V., Simion, M. L., Sperduto, J. C., Steckmeyer, C., Sutera, A., Trifirò, M., Trimarchi, G., Vannini, Vigilante, Mariano, J., Wilczynski, H., Wu, Z., Xiao, L., Zetta, and W., Zipper

Published
2001

30. Rounding error in the computation of opposite sign floating point number parametric addition: a case study

Author

G.R. Sechi and M. Bartolucci

Subjects
Computer Science::Hardware Architecture, Adder, Floating point, Computer science, Computation, Rounding, General Engineering, Hardware_ARITHMETICANDLOGICSTRUCTURES, Round-off error, Error detection and correction, Algorithm, Sign (mathematics), Parametric statistics
Abstract

This paper presents a study about rounding error arising in the addition of opposite sign floating point operands: the algebraic study of the adder functionalities provides the possibility to modify hardware in order to measure the rounding error effect in terms of error size and incoming rate.

Published
1994
Full Text
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31. Multicentre evaluation of a biphasic culture system for recovery of mycobacteria from clinical specimens

Author

F. Marchesani, Enrico Tortoli, M. T. Simonetti, C. Passerini Tosi, Valeria Penati, F. Mandler, G. Bertoli, M. Bartolucci, Antonio Goglio, C. Lacchini, B. Innocenti, and Danila Costa

Subjects
Microbiology (medical), Tuberculosis, food.ingredient, Early detection, Sensitivity and Specificity, Mycobacterium, Microbiology, Mycobacterium tuberculosis, Chocolate agar, chemistry.chemical_compound, food, medicine, Humans, Agar, Prospective Studies, Bacteriological Techniques, Mycobacterium Infections, biology, Sputum, General Medicine, biology.organism_classification, medicine.disease, Isolation (microbiology), Pleural Effusion, Infectious Diseases, chemistry, Multicenter study, Bronchoalveolar Lavage Fluid
Abstract

A new biphasic system (MB Check, Roche) for isolation of mycobacteria from clinical specimens was evaluated by eight different microbiological laboratories in comparison with methods routinely used in the respective laboratories. Altogether 1125 clinical specimens were processed; pretreatment, if performed, was by a variety of methods. Mycobacteria were recovered from 167 specimens with the biphasic system and 165 specimens with the other methods. The average time required for isolation of Mycobacterium tuberculosis was 22.6 days with the biphasic system and 24.7 days with egg-based media; for other mycobacterial species it was 23.5 versus 20.8 days. The inclusion of a chocolate agar section in the biphasic system facilitated the early detection of contaminants, while the NAP-containing section appeared unable to differentiate Mycobacterium tuberculosis from other mycobacterial species. The biphasic system, which enables recovery of mycobacteria in small laboratories without specialized equipment, is more practical than conventional methods and at least as sensitive.

Published
1993
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32. Atopic derrnatitis and food alergy in Europe - prevalence and risk factors

Author

Luisa Businco and M. Bartolucci

Subjects
medicine.medical_specialty, Allergy, business.industry, Immunology, Atopic sensitization, Atopic dermatitis, medicine.disease, medicine.disease_cause, Dermatitis, Atopic, Europe, Atopy, Allergen, Risk Factors, Food allergy, Environmental health, Epidemiology, Prevalence, medicine, Humans, Immunology and Allergy, Risk factor, business, Food Hypersensitivity
Published
1998
Full Text
View/download PDF

33. Screening of lung cancer with low dose spiral CT: results of a three year pilot study and design of the randomised controlled trial 'Italung-CT'

Author

G, Picozzi, E, Paci, A, Lopez Pegna, M, Bartolucci, G, Roselli, A, De Francisci, S, Gabrielli, A, Masi, N, Villari, and M, Mascalchi

Subjects
Male, Lung Neoplasms, Humans, Female, Pilot Projects, Middle Aged, Lung, Tomography, Spiral Computed, Randomized Controlled Trials as Topic
Abstract

To report the results of a three-year observational pilot study of lung cancer screening with low dose computed tomography (CT) and to present the study design of a randomised clinical trial named as ''Italung-CT''.Sixty (47 males and 13 females, mean age 64+/-4.5 years) heavy smokers (at least 20 packs-year) underwent three low-dose spiral CT screening tests one year apart on a single slice or multislice CT scanner. Indeterminate nodules were managed according to the recommendations of the Early Lung Cancer Action Project.and Indeterminate nodules were observed in 33 (55%) of the subjects (60% at the baseline screening test, 24% at the first annual test and 16% at the second annual test). The size of the largest indeterminate nodule was5 mm in diameter in 20 subjects, 10 of whom showed the nodule at the baseline test. Forty-five subjects (75%) completed the first annual test and 42 (70%) the second annual test. One (1.6%) prevalent lung cancer (adenosquamous carcinoma) and one (2.2%) incident lung cancer (small cell cancer at the first annual examination) were observed, as well as a pulmonary localisation of Hodgkin's lymphoma (at the second annual test). In addition, one subject underwent lung surgery for a chondromatous hamartoma.The results of the pilot study are substantially in line with those of other observational studies of greater sample size. This justifies optimism about the reliability of the results in the screened arm of the ''Italung CT'' trial which has just begun.

Published
2005

34. γδ lymphocytes in mumps meningitis patients

Author

G De Giorgi, Fabrizio Spinozzi, Alberto Bertotto, P Pazzelli, M. Bartolucci, R. Vaccaro, Roberto Gerli, G Bassotti, and N Forenza

Subjects
Pathology, medicine.medical_specialty, business.industry, T-cell receptor, General Medicine, Mumps virus, medicine.disease, medicine.disease_cause, Central nervous system disease, Immune system, Cerebrospinal fluid, Antigen, Pediatrics, Perinatology and Child Health, Immunology, Medicine, business, Meningitis, CD8
Abstract

Flowcytometric analysis on T-cell subpopulations in the blood and cerebrospinal fluid (CSF) of 10 children with mumps meningitis (MM) revealed that the proportion of lymphocytes which bore the gamma delta T-cell receptor for antigen was significantly higher in CSF than in autologous and heterologous blood samples. gamma delta T-cell values in CSF of MM patients were also significantly higher than those calculated in CSF specimens from nine children with non-inflammatory neurological disorders. Whether and how the expanded CSF gamma delta T-lymphocyte subset, either CD8+ or double-negative (CD4-/CD8-), contributes to the eradication of mumps virus infection from the central nervous system represents a central focus of our ongoing research.

Published
1995
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35. The enhanced data acquisition system for the 4π detector CHIMERA

Author

S. Aiello, M. Alderighi, A. Anzalone, M. Bartolucci, M.G. Campisi, G. Cardella, S. Cavallaro, E. De Filippo, S. Femino, E. Geraci, M. Geraci, F. Giustolisi, A. Greco, P. Guazzoni, C.M. Iacono Manno, G. Lanzalone, G. Lanzano, S. Lo Nigro, G. Manfredi, A. Pagano, M. Papa, S. Pirrone, G. Politi, F. Porto, S. Sambataro, G. Sechi, M.L. Sperduto, C.M. Sutera, and L. Zetta

Published
2003
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36. The on-line computational and control system for the 4π-detector CHIMERA

Author

S. Aiello, M. Alderighi, A. Anzalone, M. Bartolucci, G. Cardella, S. Cavallaro, E. De Filippo, S. Femino, E. Geraci, M. Geraci, F. Giustolisi, A. Greco, P. Guazzoni, M. IaconoManno, G. Lanzalone, G. Lanzano, S. LoNigro, G. Manfredi, A. Pagano, M. Papa, S. Pirrone, G. Politi, F. Porto, D. Salvadori, S. Sambataro, G. Sechi, L. Sperduto, C. Sutera, and L. Zetta

Published
2003
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37. Real-time computing of special algorithms with a DSP-based board

Author

G. Cardella, M.I. Manno, S. Pirrone, F. Rizzo, Michele Papa, L. Zetta, S. Lo Nigro, S. Sambataro, G. Lanzano, L. Sperduto, C. M. Sutera, G.R. Sechi, M. Geraci, E. De Filippo, A. Pagano, P. Guazzoni, M. Bartolucci, A. Anzalone, G. Lanzalone, F. Porto, S. Cavallaro, S. Femino, A. Di Pietro, G. Manfredi, A. Musumarra, Sebastiano Aiello, and G. Politi

Subjects
Approximation theory, Identification (information), Emulation, Correctness, Computer science, business.industry, Transcendental function, Computation, Real-time computing, business, Algorithm, Host (network), Digital signal processing
Abstract

The on-line computation of special algorithms, as power-law for particle identification in nuclear physics, is a basic problem requiring real-time computational resources that have to fit time constraints, due to the randomness of nuclear events, and assure correctness. Present work concentrates on the possibility to use a low cost commercially available DSP boards for this purpose. The used DSP board computes in real-time transcendental functions expanded in Chebychev polynomial series with assembler routines ad hoc written, in order to perform the identification of the charged particles emitted in nuclear reactions. In particular a presentation of an emulation framework is described where Assembler DSP algorithms are tested at full speed, while input and output are tested at low velocity, by using two host PC, simulating peripherals for the I/O data.

Published
2002
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38. A set of parametric operators, algebraically defined for real time data processing

Author

L. Zetta, G.R. Sechi, G. Manfredi, M. Bartolucci, and P. Guazzoni

Subjects
Multiplier (Fourier analysis), Reduction (complexity), Adder, Significand, Polynomial, Floating point, Computational complexity theory, Detectors and Experimental Techniques, Algorithm, Mathematics, Parametric statistics
Abstract

The computational complexity of a wide variety of applications, makes useful the development of new design strategies both in the direction of correctness (fault detection and avoidance) and reduction of computational time and physical device size. Since large part of numerical algorithms involves the computation of polynomial expansions in terms of sum and products of floating point numbers, one possible way to reduce both dimension and execution time of the designed devices, is to adapt the elementary operators to the very computational needs. In this paper a set of elementary floating point operators parametrically defined is presented. Multiplier, adder and numeric format conversion operators, are defined in a custom way with variable mantissa and exponent word length. Further, an application is shown in which reduction of floating point mantissa length is particularly useful for the computational time and hardware size improvement. >

Published
2002
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39. Extending a monoprocessor real-time system in a DSP-based multiprocessing environment

Author

L. Zetta, S. Cavallaro, S. Lo Nigro, S. Sambataro, E. De Filippo, G. Savino, S. Pirrone, Michele Papa, S. Femino, G. Lanzano, M. Geraci, G. Cardella, G. Lanzalone, M. Iacono Manno, C. Garusi, A. Anzalone, F. Rizzo, Sebastiano Aiello, A. Pagano, P. Guazzoni, F. Porto, F. Giusolisi, L. Sperduto, C. M. Sutera, G. Manfredi, M. Bartolucci, and G. Politi

Subjects
Digital signal processor, Computer science, business.industry, Embedded system, Multiprocessing, Sensor fusion, business, Real-time operating system, Digital signal processing, Computer hardware, Computing systems
Abstract

The paper deals with the evaluation of the real-time behavior of a proposed kind of computing system for monitoring and controlling multidetector arrays used in nuclear physics experiments. The system was implemented by extending a previous monoprocessor system in a multiprocessing environment, based on ADSP-21060-SHARC digital signal processors. The proposed system is being developed within the CHIMERA multidetector project.

Published
2002
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40. Mass and charge identification of fragments detected with the Chimera Silicon-CsI(Tl) telescopes

Author

N Le Neindre, M Alderighi, A Anzalone, R Barnà, M Bartolucci, I Berceanu, B Borderie, R Bougault, M Bruno, G Cardella, S Cavallaro, M D'Agostino, R Dayras, E De Filippo, D De Pasquale, E Geraci, F Giustolisi, A Grzeszczuk, P Guazzoni, D Guinet, M Iacono-Manno, A Italiano, S Kowalski, A Lanchais, G Lanzanó, G Lanzalone, S Li, S Lo Nigro, C Maiolino, G Manfredi, D Moisa, A Pagano, M Papa, T Paduszynski, M Petrovici, E Piasecki, S Pirrone, G Politi, A Pop, F Porto, M.F Rivet, E Rosato, S Russo, S Sambataro, G Sechi, V Simion, M.L Sperduto, J.C Steckmeyer, C Sutera, A Trifirò, L Tassan-Got, M Trimarchi, G Vannini, M Vigilante, J Wilczynski, H Wu, Z Xiao, L Zetta, W Zipper, Guesnon, Sandrine, Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)

Subjects
Physics, Nuclear and High Energy Physics, Silicon, 010308 nuclear & particles physics, Physics::Instrumentation and Detectors, [PHYS.NEXP] Physics [physics]/Nuclear Experiment [nucl-ex], chemistry.chemical_element, FOS: Physical sciences, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, Nuclear physics, chemistry, 0103 physical sciences, Nuclear Experiment (nucl-ex), 010306 general physics, Instrumentation, Nuclear Experiment
Abstract

Mass and charge identification of charged products detected with Silicon-CsI(Tl) telescopes of the Chimera apparatus is presented. An identification function, based on the Bethe-Bloch formula, is used to fit empirical correlation between Delta E and E ADC readings, in order to determine, event by event, the atomic and mass numbers of the detected charged reaction products prior to energy calibration., 24 pages, 7 .jpg figures, submitted to Nucl.Instr.A

Published
2002

41. REVERSE EXPERIMENT AT LABORATORI NAZIONALI DEL SUD

Author

Aldo Bonasera, S. Femino, W. Zipper, M. Bruno, Marcello Baldo, B. Borderie, G. Vannini, A. Pagano, P. Guazzoni, S. Pirrone, M. Bartolucci, A. Anzalone, C. Maiolino, E. C. Pollacco, M. Iacono Manno, E. D'Amico, J. Wilczynski, D. De Pasquale, H. Wu, E. De Filippo, N. De Cesare, E. Geraci, Amalia Pop, M. D'Agostino, A. Botvina, E. Fuschini, Michele Papa, M. Trimarchi, S. Kolwaski, T. Paduszynski, N. Le Neindre, J.C. Steckmeyer, M. Di Toro, Andrea Rapisarda, E. Piasecki, D. M. F. Rivet, G. Lanzano, S. Sambataro, R. Dayras, G.R. Sechi, M. Geraci, V. Simion, U. Lombardo, Mihai Petrovici, Elio Rosato, R. Bougault, F. Porto, G. Margagliotti, G. Politi, D. Guinet, G. Manfredi, C. M. Sutera, G. Lanzalone, I. Berceanu, D. Moisa, Mariano Vigilante, L. Zetta, Antonio Italiano, S. Lo Nigro, M. L. Sperduto, M. Alderighi, Zhigang Xiao, S. M. Li, Sebastiano Aiello, A. Grzeszczuk, D. Mahboub, S. Cavallaro, Maria Colonna, A. Trifilo, F. Giustolisi, R. Barna, and G. Cardella

Published
2001
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42. [Schistosomiasis of the spinal cord. The MR aspects in a case]

Author

M, Bartolucci, M, Cellerini, and M, Mascalchi

Subjects
Adult, Anthelmintics, Italy, Spinal Cord, Humans, Drug Therapy, Combination, Female, Organic Chemicals, Magnetic Resonance Imaging, Brazil, Praziquantel, Schistosomiasis mansoni, Spinal Cord Diseases
Published
2000

43. REVERSE: the first experiment with the CHIMERA detector

Author

E. Defilippo, F. Giustolisi, G. Vannini, R. Barna, M. Bartolucci, D. Guinet, Aldo Bonasera, S. Pirrone, D. Mahboub, S. Cavallaro, S. M. Li, L. Zetta, S. Femino, A. Anzalone, Antonio Italiano, M.F. Rivet, H. Wu, G.R. Sechi, Antonio Trifiro, N. Decesare, R. Bougault, W. Zipper, M. Iacono-Manno, V. Simion, G. Lanzano, Michele Papa, U. Lombardo, Elio Rosato, F. Porto, G. Cardella, Maria Colonna, I. Berceanu, T. Paduszynski, A. Botvina, Sebastiano Aiello, J.C. Steckmeyer, A. Grzeszczuk, E. Fuschini, D. Depasquale, M. Geraci, C. M. Sutera, S. Lonigro, C. Maiolino, B. Borderie, J. Wilczynski, M. Alderighi, Zhigang Xiao, E. Piasecki, Mihai Petrovici, M. D'Agostino, S. Kolwaski, G. Margagliotti, G. Politi, Andrea Rapisarda, S. Sambataro, M. Bruno, E. C. Pollacco, Amalia Pop, M. Di Toro, G. Manfredi, M. L. Sperduto, D. Moisa, Marcello Baldo, A. Pagano, P. Guazzoni, Mariano Vigilante, E. D'Amico, M. Trimarchi, R. Dayras, G. Lanzalone, N. Leneindre, Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Bonsignori G.C. Bruno M. Ventura A. Vretenar D., and REVERSE

Subjects
Physics, Chimera (genetics), Optics, business.industry, Detector, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], business
Published
2000

44. Detector array control and triggering

Author

M. Papa, F. Porto, G. Cardella, A. Anzalone, S. Pirrone, G. Lanzano, F. Rizzo, L. Zetta, G. Lanzalone, M. Iacono Manno, F. Giustolisi, S. LoNigro, Sebastiano Aiello, M. Geraci, E. De Filippo, G. Politi, S. Cavallaro, A. Pagano, P. Guazzoni, S. Sambataro, M. Bartolucci, S. Femino, C. Sutera, L. Sperduto, and G. Manfredi

Subjects
Nuclear and High Energy Physics, Engineering, business.industry, Computation, Interface (computing), Analog-to-digital converter, law.invention, Programmable logic device, Data acquisition, Nuclear Energy and Engineering, law, Nuclear electronics, Control system, Electronic engineering, Electrical and Electronic Engineering, Detectors and Experimental Techniques, business, Digital signal processing, Computer hardware
Abstract

A commercial DSP-based board installed in a host-PC was employed for the fast, on-line and real-time computation of special algorithms, in order to perform event selection and operate as a 2nd level trigger. Moreover an ad hoc built interface, realized using PLDs with a view to connecting the DSP-board to the ADCs and to the data acquisition system, has been tested in order to evaluate the performances of these programmable devices used as a look-up-table and as a decisional part of a 1st level trigger.

Published
1997

45. A three-year prospective study of specific immunotherapy to inhalant allergens: evidence of safety and efficacy in 300 children with allergic asthma

Author

A, Cantani, G, Arcese, P, Lucenti, D, Gagliesi, and M, Bartolucci

Subjects
Male, Mites, Allergens, Immunoglobulin E, Asthma, Radioallergosorbent Test, Child, Preschool, Administration, Inhalation, Animals, Humans, Pollen, Female, Immunotherapy, Child, Skin Tests
Abstract

The effectiveness and safety of specific immunotherapy (SIT) in allergic diseases such as asthma have increasingly come under question. Some authors advocate eliminating SIT as a therapeutic option for allergic patients, since the risks associated with this form of asthma may outweigh its positive effects. However, in a review of twenty-nine controlled studies in 2077 children and an equal number of controls, 27 (93.1%) have shown the effectiveness of SIT in pediatric age for the treatment of asthma due to inhalant allergens (p0.0001). The scope of this study was to ascertain whether this form of therapy is safe and effective in pediatrics. 300 children (median age 4.4 years) with asthma due to pollen or house dust mite were prospectively followed for three years. They were randomly divided into two groups: the study group and control group, being almost equal in number of children and clinical characteristics such as sex and age. No child suffered severe reactions due to SIT. Children receiving SIT had significantly greater reductions in days (p = 0.0001) and nights (p = 0.0005) without asthma and drug usage (p = 0.0003), compared with drug-treated children. In addition, the number of asthma attacks (p = 0.0001), and the quality of life were significantly improved in the study group (p = 0.0001). These findings suggest that if suitable allergen extracts are used with close observation of therapeutic indications, and children are followed by their doctors as frequently as required, SIT is effective in the treatment of pediatric asthma, with few adverse effects.

Published
1997

46. CD26 and CD31 surface antigen expression on human colostral T cells

Author

A. Bertotto, F. Spinozzi, R. Gerli, G. Castellucci, G. Bassotti, S. Crupi, G.M. Fabietti, C. Vagliasindi, N. Forenza, P. Pazzelli, M. Bartolucci, and R. Vaccaro

Subjects
CD3, Dipeptidyl Peptidase 4, T-Lymphocytes, Antigens, Differentiation, Myelomonocytic, Immune system, Antigen, Immunity, Lactation, medicine, Humans, biology, Colostrum, Antibodies, Monoclonal, T lymphocyte, Flow Cytometry, Platelet Endothelial Cell Adhesion Molecule-1, medicine.anatomical_structure, Pediatrics, Perinatology and Child Health, Immunology, Antigens, Surface, biology.protein, Female, Antibody, Cell Adhesion Molecules, Developmental Biology
Abstract

The expression levels of CD26 and CD31 surface antigens, two adhesion/activation molecules with helper and suppressor activities, respectively, were found to be significantly higher on human colostral T cells (CD3+) than in autologous peripheral blood samples. These findings provide further phenotypical evidence that immune system T lymphocytes are compartmentalized in the mammary gland late in pregnancy and during lactation. The question of whether these overexpanded T lymphocyte populations in breast milk modulate in situ, either by enhancing or suppressing, the cellular and/or humoral immune response of the suckling infant remains to be answered. Additional studies are, therefore, needed to explore this intriguing field concerning the immunology of the colostrum.

Published
1995

47. Seroprevalence of anti-HTLV I/II and anti-HIV-1 antibodies in a sample population in the Marche Region, Italy

Author

S. Cipriani, M. Bartolucci, I. Covelli, F. Mignini, and L. Quarenghi

Subjects
Anti hiv 1, Adult, medicine.medical_specialty, Adolescent, Epidemiology, Blotting, Western, Enzyme-Linked Immunosorbent Assay, HIV Antibodies, Virus, Serology, HIV Seroprevalence, HIV Seropositivity, medicine, Htlv i ii, Seroprevalence, Humans, Blood Transfusion, Child, Substance Abuse, Intravenous, Aged, Aged, 80 and over, biology, business.industry, Prisoners, virus diseases, Middle Aged, Virology, HTLV-I Antibodies, HTLV-II Antibodies, Hospitalization, Italy, Immunology, biology.protein, HIV-1, Viral disease, Antibody, business
Abstract

A total of 1292 sera, provided by different USLs (Local Health Centers) in the Marche Region (Italy), was tested by ELISA and Western Blot for the detection of anti-HTLV I/II ad HIV-1 antibodies. It was decided not to follow any particular criterion when collecting the sera, so no protocol of admission was established in advance. Of the 1292 sera tested, 12 were found antibody positive to HTLV I/II, 18 to HIV-1 and 4 to both viruses. Of the seropositives, for HTLV I/II and HIV-1, respectively, 2 and 3 were prisoners; 2 and 4 were IVDAs, 3 and 7 were hematological patients, 3 and 2 were hospitalized subjects (not for hematological disorders), and 2 and 2 were positives belonging to a healthy population group. These data suggest that the viruses may also be spreading among groups other than the high-risk ones (homosexuals, IVDAs, prisoners, blood-transfusion recipients, promiscuous heterosexuals).

Published
1994

48. Inhibition of NK binding to K562 cells induced by MAb saturation of adhesion molecules on target membrane

Author

S, Papa, A, Gregorini, E, Pascucci, M, Bartolucci, M B, Rocchi, and M, Valentini

Subjects
Killer Cells, Natural, Immunoconjugates, Leukemia, Antibody Specificity, Fluorescent Antibody Technique, Direct, Cell Membrane, Tumor Cells, Cultured, Antibodies, Monoclonal, Humans, Flow Cytometry, Cell Adhesion Molecules, T-Lymphocytes, Regulatory
Abstract

Cell to cell interaction play a major role in the induction of a immune response. NK cells represent a special lymphoid subset which displays its cytotoxic function without the engagement of MHC system. In order to investigate the role of different adhesion molecules in the mechanism of binding of the NK cell to the classic tumor target K562 cell, we have employed different unclustered mAbs of the Adhesion session (5th "CD" Workshop, Boston 1993) mostly of the CAM (cell adhesion molecule) subpanel. After their reactivity characterization both on lymphocytes and K562 cells, those that demonstrate reactivity against the tumor target were tested in the binding assay. The target was pretreated with the monoclonal in order to block a possible reacting molecule for the effector. Then, after the incubation of lymphocytes with PE-labelled anti CD16 mAb, their ability to bind to the target was tested in flow. While the majority of the mAbs did not induce any significant change in the binding capacity of the NK subset, few of them did, and precisely anti-CD58 (LFA-3) and anti-CD54 (ICAM-1) which showed different level of inhibition, particularly drastic with S002, S083 and S100. Other mAbs, such as the S011 (anti-CD59), due to the presence of the PI-linked glycoprotein recognized on both target and effector membranes, and to its capacity to stimulate NK activity, produced a total binding of the NK population. The coincubation of targets with anti-CD54 and anti-CD58 allowed to reduce at the lowest level this function. This data seem to support the hypothesis of specific surface molecules involved in the binding process of the NK cell, after recognition of the target.

Published
1994

49. The blockage of the human transferrin receptor by a monoclonal antibody, EA.3, induces growth inhibition in leukemia cell lines

Author

M, Valentini, A, Gregorini, M, Bartolucci, A, Porcellini, and S, Papa

Subjects
Leukemia, Experimental, Blotting, Western, Cell Cycle, Transferrin, Antibodies, Monoclonal, HL-60 Cells, Flow Cytometry, Cell Line, Iodine Radioisotopes, Bromodeoxyuridine, Fluorescent Antibody Technique, Direct, Culture Techniques, Receptors, Transferrin, Tumor Cells, Cultured, Humans, Electrophoresis, Polyacrylamide Gel
Abstract

In our program to produce monoclonal antibodies against hemopoietic functional antigens we have obtained an hybridoma cell line EA.3 reacting with human transferrin receptor. This monoclonal antibody is an IgM that displays "in vitro" antiproliferative activity against leukemic cells due to its competition with transferrin on the receptor. Cell cytotoxicity was demonstrated either with the blockage of BrdU incorporation in HL-60 cells and with leukemic CFU inhibition. In contrast, K562 cells were insensitive to the blockage of the transferrin receptor induced by this MAb.

Published
1994

50. Cytokinetic effects of interferon in colorectal cancer tumors: implications in the design of the interferon/5-fluorouracil combinations

Author

S, Cascinu, E, Del Ferro, A, Fedeli, C, Grianti, G, Foglietti, Q, Olivieri, M, Acetoso, M, Bartolucci, V, Saba, and F, Lungarotti

Subjects
Adult, Cell Cycle, Humans, Interferon-alpha, Drug Interactions, Fluorouracil, Interferon alpha-2, Middle Aged, Colorectal Neoplasms, Flow Cytometry, Recombinant Proteins, Aged, S Phase
Abstract

Interferon (IFN) has been shown to enhance the cytotoxic effects of 5-fluorouracil (5FUra) in colorectal cancer, and clinical trials with this combination resulted in higher response rate with respect to 5FUra alone. IFN is generally administered s.c. three times a week. This prolonged exposure could determine a block of tumor cells in the G0-G1 phase of the cell cycle, thus rendering tumor cells insensitive to 5FUra, an S-phase specific agent. In order to verify the presence of this block, 21 operable colorectal cancer patients were treated with IFN-alpha 2b at the dose of 3 megaunits every other day in the week before operation, while another 22 represented the control group. Samples of tumor tissue were taken at endoscopy and operation. [3H]Thymidine labeling index and flow cytometry were used to assess the S-phase fraction. In IFN treated patients, we found a significant statistical difference between the mean percentage of S-phase fractions evaluated either by labeling index (P = 0.00001) or by flow cytometry (P0.001). On the contrary, this difference was not present in the control group: labeling index, P = 0.06; flow cytometry, P = 0.08. Furthermore a significant increase in the G0-G1 phase of the cell cycle was found after IFN administration (P0.001) but not in the control group. Our results suggest that IFN reduces the S-phase fraction in colorectal cancer tumors. This action should be considered in the design of the 5FUra/IFN combination because it could decrease 5FUra activity, leading to a loss or a decrease in the advantage of 5FUra modulation by IFN.

Published
1993

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