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640 results on '"M. Delfino"'

1. Multimessenger Characterization of Markarian 501 during Historically Low X-Ray and γ-Ray Activity

Author: H. Abe, S. Abe, V. A. Acciari, I. Agudo, T. Aniello, S. Ansoldi, L. A. Antonelli, A. Arbet-Engels, C. Arcaro, M. Artero, K. Asano, D. Baack, A. Babić, A. Baquero, U. Barres de Almeida, J. A. Barrio, I. Batković, J. Baxter, J. Becerra González, W. Bednarek, E. Bernardini, M. Bernardos, A. Berti, J. Besenrieder, W. Bhattacharyya, C. Bigongiari, A. Biland, O. Blanch, G. Bonnoli, Ž. Bošnjak, I. Burelli, G. Busetto, R. Carosi, M. Carretero-Castrillo, A. J. Castro-Tirado, G. Ceribella, Y. Chai, A. Chilingarian, S. Cikota, E. Colombo, J. L. Contreras, J. Cortina, S. Covino, G. D’Amico, V. D’Elia, P. Da Vela, F. Dazzi, A. De Angelis, B. De Lotto, A. Del Popolo, M. Delfino, J. Delgado, C. Delgado Mendez, D. Depaoli, F. Di Pierro, L. Di Venere, E. Do Souto Espiñeira, D. Dominis Prester, A. Donini, D. Dorner, M. Doro, D. Elsaesser, G. Emery, J. Escudero, V. Fallah Ramazani, L. Fariña, A. Fattorini, L. Foffano, L. Font, C. Fruck, S. Fukami, Y. Fukazawa, R. J. García López, M. Garczarczyk, S. Gasparyan, M. Gaug, J. G. Giesbrecht Paiva, N. Giglietto, F. Giordano, P. Gliwny, N. Godinović, R. Grau, D. Green, J. G. Green, D. Hadasch, A. Hahn, T. Hassan, L. Heckmann, J. Herrera, D. Hrupec, M. Hütten, R. Imazawa, T. Inada, R. Iotov, K. Ishio, I. Jiménez Martínez, J. Jormanainen, D. Kerszberg, Y. Kobayashi, H. Kubo, J. Kushida, A. Lamastra, D. Lelas, F. Leone, E. Lindfors, L. Linhoff, S. Lombardi, F. Longo, R. López-Coto, M. López-Moya, A. López-Oramas, S. Loporchio, A. Lorini, E. Lyard, B. Machado de Oliveira Fraga, P. Majumdar, M. Makariev, G. Maneva, N. Mang, M. Manganaro, S. Mangano, K. Mannheim, M. Mariotti, M. Martínez, A. Mas-Aguilar, D. Mazin, S. Menchiari, S. Mender, S. Mićanović, D. Miceli, T. Miener, J. M. Miranda, R. Mirzoyan, E. Molina, H. A. Mondal, A. Moralejo, D. Morcuende, V. Moreno, T. Nakamori, C. Nanci, L. Nava, V. Neustroev, M. Nievas Rosillo, C. Nigro, K. Nilsson, K. Nishijima, T. Njoh Ekoume, K. Noda, S. Nozaki, Y. Ohtani, T. Oka, A. Okumura, J. Otero-Santos, S. Paiano, M. Palatiello, D. Paneque, R. Paoletti, J. M. Paredes, L. Pavletić, M. Persic, M. Pihet, G. Pirola, F. Podobnik, P. G. Prada Moroni, E. Prandini, G. Principe, C. Priyadarshi, W. Rhode, M. Ribó, J. Rico, C. Righi, A. Rugliancich, N. Sahakyan, T. Saito, S. Sakurai, K. Satalecka, F. G. Saturni, B. Schleicher, K. Schmidt, F. Schmuckermaier, J. L. Schubert, T. Schweizer, J. Sitarek, V. Sliusar, D. Sobczynska, A. Spolon, A. Stamerra, J. Strišković, D. Strom, M. Strzys, Y. Suda, T. Surić, H. Tajima, M. Takahashi, R. Takeishi, F. Tavecchio, P. Temnikov, K. Terauchi, T. Terzić, M. Teshima, L. Tosti, S. Truzzi, A. Tutone, S. Ubach, J. van Scherpenberg, M. Vazquez Acosta, S. Ventura, V. Verguilov, I. Viale, C. F. Vigorito, V. Vitale, I. Vovk, R. Walter, M. Will, C. Wunderlich, T. Yamamoto, D. Zarić, The MAGIC Collaboration, M. Cerruti, J. A. Acosta-Pulido, G. Apolonio, R. Bachev, M. Baloković, E. Benítez, I. Björklund, V. Bozhilov, L. F. Brown, A. Bugg, W. Carbonell, M. I. Carnerero, D. Carosati, C. Casadio, W. Chamani, W. P. Chen, R. A. Chigladze, G. Damljanovic, K. Epps, A. Erkenov, M. Feige, J. Finke, A. Fuentes, K. Gazeas, M. Giroletti, T. S. Grishina, A. C. Gupta, M. A. Gurwell,, E. Heidemann, D. Hiriart, W. J. Hou, T. Hovatta, S. Ibryamov, M. D. Joner, S. G. Jorstad, J. Kania, S. Kiehlmann, G. N. Kimeridze, E. N. Kopatskaya, M. Kopp, M. Korte, B. Kotas, S. Koyama, J. A. Kramer, L. Kunkel, S. O. Kurtanidze, O. M. Kurtanidze, A. Lähteenmäki, J. M. López, V. M. Larionov, E. G. Larionova, L. V. Larionova, C. Leto, C. Lorey, R. Mújica, G. M. Madejski, N. Marchili, A. P. Marscher, M. Minev, A. Modaressi, D. A. Morozova, T. Mufakharov, I. Myserlis, A. A. Nikiforova, M. G. Nikolashvili, E. Ovcharov, M. Perri, C. M. Raiteri, A. C. S. Readhead, A. Reimer, D. Reinhart, S. Righini, K. Rosenlehner, A. C. Sadun, S. S. Savchenko, A. Scherbantin, L. Schneider, K. Schoch, D. Seifert, E. Semkov, L. A. Sigua, C. Singh, P. Sola, Y. Sotnikova, M. Spencer, R. Steineke, M. Stojanovic, A. Strigachev, M. Tornikoski, E. Traianou, A. Tramacere, Yu. V. Troitskaya, I. S. Troitskiy, J. B. Trump, A. Tsai, A. Valcheva, A. A. Vasilyev, F. Verrecchia, M. Villata, O. Vince, K. Vrontaki, Z. R. Weaver, E. Zaharieva, and N. Zottmann
Subjects: Active galaxies, BL Lacertae objects, Markarian galaxies, Active galactic nuclei, Blazars, Astrophysics, QB460-466
Abstract: We study the broadband emission of Mrk 501 using multiwavelength observations from 2017 to 2020 performed with a multitude of instruments, involving, among others, MAGIC, Fermi's Large Area Telescope (LAT), NuSTAR, Swift, GASP-WEBT, and the Owens Valley Radio Observatory. Mrk 501 showed an extremely low broadband activity, which may help to unravel its baseline emission. Nonetheless, significant flux variations are detected at all wave bands, with the highest occurring at X-rays and very-high-energy (VHE) γ -rays. A significant correlation (>3 σ ) between X-rays and VHE γ -rays is measured, supporting leptonic scenarios to explain the variable parts of the emission, also during low activity. This is further supported when we extend our data from 2008 to 2020, and identify, for the first time, significant correlations between the Swift X-Ray Telescope and Fermi-LAT. We additionally find correlations between high-energy γ -rays and radio, with the radio lagging by more than 100 days, placing the γ -ray emission zone upstream of the radio-bright regions in the jet. Furthermore, Mrk 501 showed a historically low activity in X-rays and VHE γ -rays from mid-2017 to mid-2019 with a stable VHE flux (>0.2 TeV) of 5% the emission of the Crab Nebula. The broadband spectral energy distribution (SED) of this 2 yr long low state, the potential baseline emission of Mrk 501, can be characterized with one-zone leptonic models, and with (lepto)-hadronic models fulfilling neutrino flux constraints from IceCube. We explore the time evolution of the SED toward the low state, revealing that the stable baseline emission may be ascribed to a standing shock, and the variable emission to an additional expanding or traveling shock.
Published: 2023
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2. A Problem-Based Learning Activity for Enhancing Inquiry Skills and Facilitating Conceptual Change in a Biological Chemistry Course

Author: Wanda M. Valsecchi, Jose M. Delfino, Javier Santos, and Santiago E. Faraj
Abstract: When teaching STEM courses, it is important to introduce state-of-the-art techniques. Students need to learn how to conduct experiments, analyse data and choose the most effective approaches to address meaningful situations. Here we present the assessment of the implementation of a structured inquiry-based activity aimed at teaching students about protein mass and size. This activity emerges as an intervention in our educational module, designed to create a cognitive conflict that effectively drives a conceptual change. To evaluate the efficacy of this module, we collected data on students' perceived and actual knowledge through pre- and post-class surveys (n = 36 and 34, respectively, mean age 26 ± 2). Additionally, we evaluated lab reports using a detailed rubric. Results indicate that the practical innovation we propose is a challenging activity that promotes the accomplishment of our learning objectives. The activity led to improvements both in confidence and in actual mastery of theoretical concepts and techniques. After completing the activity, students were able to choose the most appropriate technique to solve specific problems. Furthermore, we found that the use of a structured questionnaire in lab reports helped students to accurately analyse and process experimental data. It also allows them to demonstrate understanding of technical limitations, while integrating the knowledge and skills acquired during the module. Overall, this activity provides notions that are conceivable and profitable, thus leading to successful conceptual changes.
Published: 2024
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3. Cherenkov Telescope Array Contributions to the 35th International Cosmic Ray Conference (ICRC2017)

Author: Acero, F., Acharya, B. S., Portella, V. Acín, Adams, C., Agudo, I., Aharonian, F., Samarai, I. Al, Alberdi, A., Alcubierre, M., Alfaro, R., Alfaro, J., Alispach, C., Aloisio, R., Batista, R. Alves, Amans, J. -P., Amato, E., Ambrogi, L., Ambrosi, G., Ambrosio, M., Anderson, J., Anduze, M., Angüner, E. O., Antolini, E., Antonelli, L. A., Antonuccio, V., Antoranz, P., Aramo, C., Araya, M., Arcaro, C., Armstrong, T., Arqueros, F., Arrabito, L., Arrieta, M., Asano, K., Asano, A., Ashley, M., Aubert, P., Singh, C. B., Babic, A., Backes, M., Bajtlik, S., Balazs, C., Balbo, M., Ballester, O., Ballet, J., Ballo, L., Balzer, A., Bamba, A., Bandiera, R., Barai, P., Barbier, C., Barcelo, M., Barkov, M., de Almeida, U. Barres, Barrio, J. A., Bastieri, D., Bauer, C., Becciani, U., Becherini, Y., Tjus, J. Becker, Bednarek, W., Belfiore, A., Benbow, W., Benito, M., Berge, D., Bernardini, E., Bernardini, M. G., Bernardos, M., Bernhard, S., Bernlöhr, K., Salucci, C. Bertinelli, Bertucci, B., Besel, M. -A., Beshley, V., Bettane, J., Bhatt, N., Bhattacharyya, W., Bhattachryya, S., Biasuzzi, B., Bicknell, G., Bigongiari, C., Biland, A., Bilinsky, A., Bird, R., Bissaldi, E., Biteau, J., Bitossi, M., Blanch, O., Blasi, P., Blazek, J., Boccato, C., Bockermann, C., Boehm, C., Bohacova, M., Boisson, C., Bolmont, J., Bonanno, G., Bonardi, A., Bonavolontà, C., Bonnoli, G., Borkowski, J., Bose, R., Bosnjak, Z., Böttcher, M., Boutonnet, C., Bouyjou, F., Bowman, L., Bozhilov, V., Braiding, C., Brau-Nogué, S., Bregeon, J., Briggs, M., Brill, A., Brisken, W., Bristow, D., Britto, R., Brocato, E., Brown, A. M., Brown, S., Brügge, K., Brun, P., Brun, F., Brunetti, L., Brunetti, G., Bruno, P., Bryan, M., Buckley, J., Bugaev, V., Bühler, R., Bulgarelli, A., Bulik, T., Burton, M., Burtovoi, A., Busetto, G., Buson, S., Buss, J., Byrum, K., Caccianiga, A., Cameron, R., Canelli, F., Canestrari, R., Capalbi, M., Capasso, M., Capitanio, F., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Cárdenas, V., Cardenzana, J., Cardillo, M., Carlile, C., Caroff, S., Carosi, R., Carosi, A., Carquín, E., Carr, J., Casandjian, J. -M., Casanova, S., Cascone, E., Castro-Tirado, A. J., Mora, J. Castroviejo, Catalani, F., Catalano, O., Cauz, D., Silva, C. Celestino, Celli, S., Cerruti, M., Chabanne, E., Chadwick, P., Chakraborty, N., Champion, C., Chatterjee, A., Chaty, S., Chaves, R., Chen, A., Chen, X., Cheng, K., Chernyakova, M., Chikawa, M., Chitnis, V. R., Christov, A., Chudoba, J., Cieślar, M., Clark, P., Coco, V., Colafrancesco, S., Colin, P., Colombo, E., Colome, J., Colonges, S., Conforti, V., Connaughton, V., Conrad, J., Contreras, J. L., Cornat, R., Cortina, J., Costa, A., Costantini, H., Cotter, G., Courty, B., Covino, S., Covone, G., Cristofari, P., Criswell, S. J., Crocker, R., Croston, J., Crovari, C., Cuadra, J., Cuevas, O., Cui, X., Cumani, P., Cusumano, G., D'Aì, A., D'Ammando, F., D'Avanzo, P., D'Urso, D., Da Vela, P., Dale, Ø., Dang, V. T., Dangeon, L., Daniel, M., Davids, I., Dawson, B., Dazzi, F., De Angelis, A., De Caprio, V., Anjos, R. de Cássia dos, De Cesare, G., De Franco, A., De Frondat, F., Pino, E. M. de Gouveia Dal, de la Calle, I., De Lisio, C., Lopez, R. de los Reyes, De Lotto, B., De Luca, A., De Lucia, M., Neto, J. R. T. de Mello, de Naurois, M., Wilhelmi, E. de Oña, De Palma, F., De Persio, F., de Souza, V., Decock, J., Deil, C., Deiml, P., Del Santo, M., Delagnes, E., Deleglise, G., Reznicek, M. Delfino, Delgado, C., Mengual, J. Delgado, Della Ceca, R., della Volpe, D., Detournay, M., Devin, J., Di Girolamo, T., Di Giulio, C., Di Pierro, F., Di Venere, L., Diaz, L., Díaz, C., Dib, C., Dickinson, H., Diebold, S., Digel, S., Djannati-Ataï, A., Doert, M., Domínguez, A., Prester, D. Dominis, Donnarumma, I., Dorner, D., Doro, M., Dournaux, J. -L., Downes, T., Drake, G., Drappeau, S., Drass, H., Dravins, D., Drury, L., Dubus, G., Morå, K. Dundas, Durkalec, A., Dwarkadas, V., Ebr, J., Eckner, C., Edy, E., Egberts, K., Einecke, S., Eisch, J., Eisenkolb, F., Ekoume, T. R. N., Eleftheriadis, C., Elsässer, D., Emmanoulopoulos, D., Ernenwein, J. -P., Escarate, P., Eschbach, S., Espinoza, C., Evans, P., Evoli, C., Fairbairn, M., Falceta-Goncalves, D., Falcone, A., Ramazani, V. Fallah, Farakos, K., Farrell, E., Fasola, G., Favre, Y., Fede, E., Fedora, R., Fedorova, E., Fegan, S., Fernandez-Alonso, M., Fernández-Barral, A., Ferrand, G., Ferreira, O., Fesquet, M., Fiandrini, E., Fiasson, A., Filipovic, M., Fink, D., Finley, J. P., Finley, C., Finoguenov, A., Fioretti, V., Fiorini, M., Flores, H., Foffano, L., Föhr, C., Fonseca, M. V., Font, L., Fontaine, G., Fornasa, M., Fortin, P., Fortson, L., Fouque, N., Fraga, B., Franco, F. J., Coromina, L. Freixas, Fruck, C., Fugazza, D., Fujita, Y., Fukami, S., Fukazawa, Y., Fukui, Y., Funk, S., Furniss, A., Füßling, M., Gabici, S., Gadola, A., Gallant, Y., Galloway, D., Gallozzi, S., Garcia, B., Garcia, A., Gil, R. García, López, R. Garcia, Garczarczyk, M., Gardiol, D., Gargano, F., Gargano, C., Garozzo, S., Garrido-Ruiz, M., Gascon, D., Gasparetto, T., Gaté, F., Gaug, M., Gebhardt, B., Gebyehu, M., Geffroy, N., Genolini, B., Ghalumyan, A., Ghedina, A., Ghirlanda, G., Giammaria, P., Gianotti, F., Giebels, B., Giglietto, N., Gika, V., Gimenes, R., Giommi, P., Giordano, F., Giovannini, G., Giro, E., Giroletti, M., Gironnet, J., Giuliani, A., Glicenstein, J. -F., Gnatyk, R., Godinovic, N., Goldoni, P., Gómez, J. L., Gómez-Vargas, G., González, M. M., González, J. M., Gothe, K. S., Gotz, D., Goullon, J., Grabarczyk, T., Graciani, R., Graham, J., Grandi, P., Granot, J., Grasseau, G., Gredig, R., Green, A. J., Greenshaw, T., Grenier, I., Griffiths, S., Grillo, A., Grondin, M. -H., Grube, J., Guarino, V., Guest, B., Gueta, O., Gunji, S., Gyuk, G., Hadasch, D., Hagge, L., Hahn, J., Hahn, A., Hakobyan, H., Hara, S., Hardcastle, M. J., Hassan, T., Haubold, T., Haupt, A., Hayashi, K., Hayashida, M., He, H., Heller, M., Helo, J. C., Henault, F., Henri, G., Hermann, G., Hermel, R., Llorente, J. Herrera, Herrero, A., Hervet, O., Hidaka, N., Hinton, J., Hiroshima, N., Hirotani, K., Hnatyk, B., Hoang, J. K., Hoffmann, D., Hofmann, W., Holder, J., Horan, D., Hörandel, J., Hörbe, M., Horns, D., Horvath, P., Houles, J., Hovatta, T., Hrabovsky, M., Hrupec, D., Huet, J. -M., Hughes, G., Hui, D., Hull, G., Humensky, T. B., Hussein, M., Hütten, M., Iarlori, M., Ikeno, Y., Illa, J. M., Impiombato, D., Inada, T., Ingallinera, A., Inome, Y., Inoue, S., Inoue, T., Inoue, Y., Iocco, F., Ioka, K., Ionica, M., Iori, M., Iriarte, A., Ishio, K., Israel, G. L., Iwamura, Y., Jablonski, C., Jacholkowska, A., Jacquemier, J., Jamrozy, M., Janecek, P., Jankowsky, F., Jankowsky, D., Jansweijer, P., Jarnot, C., Jean, P., Johnson, C. A., Josselin, M., Jung-Richardt, I., Jurysek, J., Kaaret, P., Kachru, P., Kagaya, M., Kakuwa, J., Kalekin, O., Kankanyan, R., Karastergiou, A., Karczewski, M., Karkar, S., Katagiri, H., Kataoka, J., Katarzyński, K., Katz, U., Kawanaka, N., Kaye, L., Kazanas, D., Kelley-Hoskins, N., Khélifi, B., Kieda, D. B., Kihm, T., Kimeswenger, S., Kimura, S., Kisaka, S., Kishida, S., Kissmann, R., Kluźniak, W., Knapen, J., Knapp, J., Knödlseder, J., Koch, B., Kocot, J., Kohri, K., Komin, N., Kong, A., Konno, Y., Kosack, K., Kowal, G., Koyama, S., Kraus, M., Krause, M., Krauß, F., Krennrich, F., Kruger, P., Kubo, H., Kudryavtsev, V., Mezek, G. Kukec, Kumar, S., Kuroda, H., Kushida, J., Kushwaha, P., La Palombara, N., La Parola, V., La Rosa, G., Lahmann, R., Lalik, K., Lamanna, G., Landoni, M., Landriu, D., Landt, H., Lang, R. G., Lapington, J., Laporte, P., Blanc, O. Le, Flour, T. Le, Sidaner, P. Le, Leach, S., Leckngam, A., Lee, S. -H., Lee, W. H., Lees, J. -P., Lefaucheur, J., de Oliveira, M. A. Leigui, Lemoine-Goumard, M., Lenain, J. -P., Leto, G., Lico, R., Limon, M., Lindemann, R., Lindfors, E., Linhoff, L., Lipniacka, A., Lloyd, S., Lohse, T., Lombardi, S., Longo, F., Lopez, M., Lopez-Coto, R., Louge, T., Louis, F., Louys, M., Lucarelli, F., Lucchesi, D., Luque-Escamilla, P. L., Lyard, E., Maccarone, M. C., Maccarone, T., Mach, E., Madejski, G. M., Maier, G., Majczyna, A., Majumdar, P., Makariev, M., Malaguti, G., Malouf, A., Maltezos, S., Malyshev, D., Mandat, D., Maneva, G., Manganaro, M., Mangano, S., Manigot, P., Mannheim, K., Maragos, N., Marano, D., Marcowith, A., Marín, J., Mariotti, M., Marisaldi, M., Markoff, S., Martí, J., Martin, J. -M., Martin, P., Martin, L., Martínez, M., Martínez, G., Martínez, O., Marx, R., Masetti, N., Massimino, P., Mastichiadis, A., Mastropietro, M., Masuda, S., Matsumoto, H., Matthews, N., Mattiazzo, S., Maurin, G., Maxted, N., Mayer, M., Mazin, D., Mazziotta, M. N., Comb, L. Mc, McHardy, I., Medina, C., Melandri, A., Melioli, C., Melkumyan, D., Mereghetti, S., Meunier, J. -L., Meures, T., Meyer, M., Micanovic, S., Michael, T., Michałowski, J., Mievre, I., Miller, J., Minaya, I. A., Mineo, T., Mirabel, F., Miranda, J. M., Mirzoyan, R., Mitchell, A., Mizuno, T., Moderski, R., Mohammed, M., Mohrmann, L., Molijn, C., Molinari, E., Moncada, R., Montaruli, T., Monteiro, I., Mooney, D., Moore, P., Moralejo, A., Morcuende-Parrilla, D., Moretti, E., Mori, K., Morlino, G., Morris, P., Morselli, A., Moscato, F., Motohashi, D., Moulin, E., Mueller, S., Mukherjee, R., Munar, P., Mundell, C., Mundet, J., Murach, T., Muraishi, H., Murase, K., Murphy, A., Nagai, A., Nagar, N., Nagataki, S., Nagayoshi, T., Nagesh, B. K., Naito, T., Nakajima, D., Nakamori, T., Nakamura, Y., Nakayama, K., Naumann, D., Nayman, P., Neise, D., Nellen, L., Nemmen, R., Neronov, A., Neyroud, N., Nguyen, T., Nguyen, T. T., Trung, T. Nguyen, Nicastro, L., Nicolau-Kukliński, J., Niemiec, J., Nieto, D., Nievas-Rosillo, M., Nikołajuk, M., Nishijima, K., Nishikawa, K. -I., Nishiyama, G., Noda, K., Nogues, L., Nolan, S., Nosek, D., Nöthe, M., Novosyadlyj, B., Nozaki, S., Nunio, F., O'Brien, P., Oakes, L., Ocampo, C., Ochoa, J. P., Oger, R., Ohira, Y., Ohishi, M., Ohm, S., Okazaki, N., Okumura, A., Olive, J. -F., Ong, R. A., Orienti, M., Orito, R., Orlati, A., Osborne, J. P., Ostrowski, M., Otte, N., Ou, Z., Ovcharov, E., Oya, I., Ozieblo, A., Padovani, M., Paiano, S., Paizis, A., Palacio, J., Palatiello, M., Palatka, M., Pallotta, J., Panazol, J. -L., Paneque, D., Panter, M., Paoletti, R., Paolillo, M., Papitto, A., Paravac, A., Paredes, J. M., Pareschi, G., Parsons, R. D., Paśko, P., Pavy, S., Pe'er, A., Pech, M., Pedaletti, G., Del Campo, P. Peñil, Perez, A., Pérez-Torres, M. A., Perri, L., Perri, M., Persic, M., Petrashyk, A., Petrera, S., Petrucci, P. -O., Petruk, O., Peyaud, B., Pfeifer, M., Piano, G., Piel, Q., Pieloth, D., Pintore, F., García, C. Pio, Pisarski, A., Pita, S., Pizarro, L., Platos, Ł., Pohl, M., Poireau, V., Pollo, A., Porthault, J., Poutanen, J., Pozo, D., Prandini, E., Prasit, P., Prast, J., Pressard, K., Principe, G., Prokhorov, D., Prokoph, H., Prouza, M., Pruteanu, G., Pueschel, E., Pühlhofer, G., Puljak, I., Punch, M., Pürckhauer, S., Queiroz, F., Quinn, J., Quirrenbach, A., Rafighi, I., Rainò, S., Rajda, P. J., Rando, R., Rannot, R. C., Razzaque, S., Reichardt, I., Reimer, O., Reimer, A., Reisenegger, A., Renaud, M., Reposeur, T., Reville, B., Rezaeian, A. H., Rhode, W., Ribeiro, D., Ribó, M., Richer, M. G., Richtler, T., Rico, J., Rieger, F., Riquelme, M., Ristori, P. R., Rivoire, S., Rizi, V., Rodriguez, J., Fernandez, G. Rodriguez, Vázquez, J. J. Rodríguez, Rojas, G., Romano, P., Romeo, G., Roncadelli, M., Rosado, J., Rosen, S., Lees, S. Rosier, Rousselle, J., Rovero, A. C., Rowell, G., Rudak, B., Rugliancich, A., del Mazo, J. E. Ruíz, Rujopakarn, W., Rulten, C., Russo, F., Saavedra, O., Sabatini, S., Sacco, B., Sadeh, I., Hatlen, E. Sæther, Safi-Harb, S., Sahakian, V., Sailer, S., Saito, T., Sakaki, N., Sakurai, S., Salek, D., Greus, F. Salesa, Salina, G., Sanchez, D., Sánchez-Conde, M., Sandaker, H., Sandoval, A., Sangiorgi, P., Sanguillon, M., Sano, H., Santander, M., Santangelo, A., Santos, E. M., Sanuy, A., Sapozhnikov, L., Sarkar, S., Satalecka, K., Sato, Y., Saturni, F. G., Savalle, R., Sawada, M., Schanne, S., Schioppa, E. J., Schlenstedt, S., Schmidt, T., Schmoll, J., Schneider, M., Schoorlemmer, H., Schovanek, P., Schulz, A., Schussler, F., Schwanke, U., Schwarz, J., Schweizer, T., Schwemmer, S., Sciacca, E., Scuderi, S., Seglar-Arroyo, M., Segreto, A., Seitenzahl, I., Semikoz, D., Sergijenko, O., Serre, N., Servillat, M., Seweryn, K., Shah, K., Shalchi, A., Sharma, M., Shellard, R. C., Shilon, I., Sidoli, L., Sidz, M., Siejkowski, H., Silk, J., Sillanpää, A., Simone, D., Singh, B. B., Sironi, G., Sitarek, J., Sizun, P., Sliusar, V., Slowikowska, A., Smith, A., Sobczyńska, D., Sokolenko, A., Sol, H., Sottile, G., Springer, W., Stahl, O., Stamerra, A., Stanič, S., Starling, R., Staszak, D., Stawarz, Ł., Steenkamp, R., Stefanik, S., Stegmann, C., Steiner, S., Stella, C., Stephan, M., Sternberger, R., Sterzel, M., Stevenson, B., Stodulska, M., Stodulski, M., Stolarczyk, T., Stratta, G., Straumann, U., Stuik, R., Suchenek, M., Suomijarvi, T., Supanitsky, A. D., Suric, T., Sushch, I., Sutcliffe, P., Sykes, J., Szanecki, M., Szepieniec, T., Tagliaferri, G., Tajima, H., Takahashi, K., Takahashi, H., Takahashi, M., Takalo, L., Takami, S., Takata, J., Takeda, J., Tam, T., Tanaka, M., Tanaka, T., Tanaka, Y., Tanaka, S., Tanci, C., Tavani, M., Tavecchio, F., Tavernet, J. -P., Tayabaly, K., Tejedor, L. A., Temme, F., Temnikov, P., Terada, Y., Terrazas, J. C., Terrier, R., Terront, D., Terzic, T., Tescaro, D., Teshima, M., Testa, V., Thoudam, S., Tian, W., Tibaldo, L., Tiengo, A., Tiziani, D., Tluczykont, M., Peixoto, C. J. Todero, Tokanai, F., Tokarz, M., Toma, K., Tomastik, J., Tonachini, A., Tonev, D., Tornikoski, M., Torres, D. F., Torresi, E., Tosti, G., Totani, T., Tothill, N., Toussenel, F., Tovmassian, G., Trakarnsirinont, N., Travnicek, P., Trichard, C., Trifoglio, M., Pujadas, I. Troyano, Tsirou, M., Tsujimoto, S., Tsuru, T., Uchiyama, Y., Umana, G., Uslenghi, M., Vagelli, V., Vagnetti, F., Valentino, M., Vallania, P., Valore, L., Berg, A. M. Van den, van Driel, W., van Eldik, C., van Soelen, B., Vandenbroucke, J., Vanderwalt, J., Varner, G. S., Vasileiadis, G., Vassiliev, V., Vázquez, J. R., Acosta, M. Vázquez, Vecchi, M., Vega, A., Veitch, P., Venault, P., Venter, C., Vercellone, S., Veres, P., Vergani, S., Verzi, V., Vettolani, G. P., Veyssiere, C., Viana, A., Vicha, J., Vigorito, C., Villanueva, J., Vincent, P., Vink, J., Visconti, F., Vittorini, V., Voelk, H., Voisin, V., Vollhardt, A., Vorobiov, S., Vovk, I., Vrastil, M., Vuillaume, T., Wagner, S. J., Wagner, R., Wagner, P., Wakely, S. P., Walstra, T., Walter, R., Ward, M., Ward, J. E., Warren, D., Watson, J. J., Webb, N., Wegner, P., Weiner, O., Weinstein, A., Weniger, C., Werner, F., Wetteskind, H., White, M., White, R., Wierzcholska, A., Wiesand, S., Wijers, R., Wilcox, P., Wilhelm, A., Wilkinson, M., Will, M., Williams, D. A., Winter, M., Wojcik, P., Wolf, D., Wood, M., Wörnlein, A., Wu, T., Yadav, K. K., Yaguna, C., Yamamoto, T., Yamamoto, H., Yamane, N., Yamazaki, R., Yanagita, S., Yang, L., Yelos, D., Yoshida, T., Yoshida, M., Yoshiike, S., Yoshikoshi, T., Yu, P., Zaborov, D., Zacharias, M., Zaharijas, G., Zajczyk, A., Zampieri, L., Zandanel, F., Zanin, R., Sanchez, R. Zanmar, Zaric, D., Zavrtanik, M., Zavrtanik, D., Zdziarski, A. A., Zech, A., Zechlin, H., Zhdanov, V. I., Ziegler, A., Ziemann, J., Ziętara, K., Zink, A., Ziółkowski, J., Zitelli, V., Zoli, A., and Zorn, J.
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: List of contributions from the Cherenkov Telescope Array Consortium presented at the 35th International Cosmic Ray Conference, July 12-20 2017, Busan, Korea., Comment: Index of Cherenkov Telescope Array conference proceedings at the ICRC2017, Busan, Korea
Published: 2017

4. Multiwavelength study of the gravitationally lensed blazar QSO B0218+357 between 2016 and 2020

Author: V A Acciari, S Ansoldi, L A Antonelli, A Arbet Engels, M Artero, K Asano, D Baack, A Babić, A Baquero, U Barres de Almeida, J A Barrio, I Batković, J Becerra González, W Bednarek, L Bellizzi, E Bernardini, M Bernardos, A Berti, J Besenrieder, W Bhattacharyya, C Bigongiari, A Biland, O Blanch, G Bonnoli, Ž Bošnjak, G Busetto, R Carosi, G Ceribella, M Cerruti, Y Chai, A Chilingarian, S Cikota, S M Colak, E Colombo, J L Contreras, J Cortina, S Covino, G D’Amico, V D’Elia, P Da Vela, F Dazzi, A De Angelis, B De Lotto, M Delfino, J Delgado, C Delgado Mendez, D Depaoli, F Di Pierro, L Di Venere, E Do Souto Espiñeira, D Dominis Prester, A Donini, D Dorner, M Doro, D Elsaesser, V Fallah Ramazani, A Fattorini, G Ferrara, M V Fonseca, L Font, C Fruck, S Fukami, R J García López, M Garczarczyk, S Gasparyan, M Gaug, N Giglietto, F Giordano, P Gliwny, N Godinović, J G Green, D Green, D Hadasch, A Hahn, L Heckmann, J Herrera, J Hoang, D Hrupec, M Hütten, T Inada, S Inoue, K Ishio, Y Iwamura, I Jiménez, J Jormanainen, L Jouvin, Y Kajiwara, M Karjalainen, D Kerszberg, Y Kobayashi, H Kubo, J Kushida, A Lamastra, D Lelas, F Leone, E Lindfors, S Lombardi, F Longo, R López-Coto, M López-Moya, A López-Oramas, S Loporchio, B Machado de Oliveira Fraga, C Maggio, P Majumdar, M Makariev, M Mallamaci, G Maneva, M Manganaro, K Mannheim, L Maraschi, M Mariotti, M Martínez, D Mazin, S Menchiari, S Mender, S Mićanović, D Miceli, T Miener, M Minev, J M Miranda, R Mirzoyan, E Molina, A Moralejo, D Morcuende, V Moreno, E Moretti, V Neustroev, C Nigro, K Nilsson, K Nishijima, K Noda, S Nozaki, Y Ohtani, T Oka, J Otero-Santos, S Paiano, M Palatiello, D Paneque, R Paoletti, J M Paredes, L Pavletić, P Peñil, C Perennes, M Persic, P G Prada Moroni, E Prandini, C Priyadarshi, I Puljak, W Rhode, M Ribó, J Rico, C Righi, A Rugliancich, L Saha, N Sahakyan, T Saito, S Sakurai, K Satalecka, F G Saturni, B Schleicher, K Schmidt, T Schweizer, J Sitarek, I Šnidarić, D Sobczynska, A Spolon, A Stamerra, D Strom, M Strzys, Y Suda, T Surić, M Takahashi, F Tavecchio, P Temnikov, T Terzić, M Teshima, L Tosti, S Truzzi, A Tutone, S Ubach, J van Scherpenberg, G Vanzo, M Vazquez Acosta, S Ventura, V Verguilov, C F Vigorito, V Vitale, I Vovk, M Will, C Wunderlich, D Zarić, F de Palma, F D’Ammando, A Barnacka, D K Sahu, M Hodges, T Hovatta, S Kiehlmann, W Max-Moerbeck, A C S Readhead, R Reeves, T J Pearson, A Lähteenmäki, I Björklund, M Tornikoski, J Tammi, S Suutarinen, K Hada, and K Niinuma
Published: 2021
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5. Multiwavelength Variability and Correlation Studies of Mrk 421 During Historically Low X-ray and Y-ray Activity in 2015–2016

Author: Janeth Valverde Quispe, V. A. Acciari, S. Ansoldi, L. A. Antonelli, K. Asano, A. Babic, B. Banerjee, A. Baquero, U.BarresdeAlmeida, J. A. Barrio, J. Becerra Gonzalez, W. Bednarek, L. Bellizzi, E. Bernardini, M. Bernardos, A. Berti, J. Besenrieder, W. Bhattacharyya, C. Bigongiari, O. Blanch, G. Bonnoli, Z. Bosnjak, G. Busetto, R. Carosi, G. Ceribella, M. Cerruti, Y. Chai, A. Chilingarian, S. Cikota, S. M. Colak, E. Colombo, J. L. Contreras, J. Cortina, S. Covino, G. D’Amico, V. D’Elia, P. Da Vela, F. Dazzi, A. De Angelis, B. De Lotto, M. Delfino, J. Delgado, C. Delgado Mendez, D. Depaoli, T. Di Girolamo, F. Di Pierro, L. Di Venere, E. Do Souto Espineira, D. Dominis Prester, A. Donini, M. Doro, V. Fallah Ramazani, A. Fattorini, G. Ferrara, L. Foffano, M. V. Fonseca, L. Font, C. Fruck, S. Fukami, R. J. Garcıa Lopez, M. Garczarczyk, S. Gasparyan, M. Gaug, N. Giglietto, F. Giordano, P. Gliwny, N. Godinovic, J. G. Green, D. Green, D. Hadasch, A. Hahn, L. Heckmann, J. Herrera, J. Hoang, D. Hrupec, M. Hutten, T. Inada, S. Inoue, K. Ishio, Y. Iwamura, J. Jormanainen, L. Jouvin, Y. Kajiwara, M. Karjalainen, D. Kerszberg, Y. Kobayashi, H. Kubo, J. Kushida, A. Lamastra, D. Lelas, F. Leone, E. Lindfors, S. Lombardi, F. Longo, M. Lopez, R. Lopez-Coto, A. Lopez-Oramas, S. Loporchio, B. Machado de Oliveira Fraga, C. Maggio, P. Majumdar, M. Makariev, M. Mallamaci, G. Maneva, M. Manganaro, L. Maraschi, M. Mariotti, M. Martınez, D. Mazin, S. Mender, S. Micanovic, D. Miceli, T. Miener, M. Minev, J. M. Miranda, R. Mirzoyan, E. Molina, A. Moralejo, D. Morcuende, V. Moreno, E. Moretti, P. Munar-Adrover, V. Neustroev, C. Nigro, K. Nilsson, D. Ninci, K. Nishijima, K. Noda, S. Nozaki, Y. Ohtani, T. Oka, J. Otero-Santos, M. Palatiello, D. Paneque, R. Paoletti, J. M. Paredes, L. Pavletic, P. P enil, C. Perennes, M. Persic, P. G . Prada Moroni, E. Prandini, C. Priyadarshi, I. Puljak, W. Rhode, M. Ribo, J. Rico, C. Righi, A. Rugliancich, L. Saha, N. Sahakyan, T. Saito, S. Sakurai, K. Satalecka, B. Schleicher, K. Schmidt, T. Schweizer, J. Sitarek, I. Snidaric, D. Sobczynska, A. Spolon, A. Stamerra, D. Strom, M. Strzys, Y. Suda, T. Suric, M. Takahashi, F. Tavecchio, P. Temnikov, T. Terzic, M. Teshima, N. Torres-Alba, L. Tosti, S. Truzzi, J. van Scherpenberg, G. Vanzo, M. Vazquez Acosta, S. Ventura, V. Verguilov, C. F. Vigorito, V. Vitale, I. Vovk, M. Will, D. Zaric, A. Arbet-Engels, D. Baack, M. Balbo, M. Beck, N. Biederbeck, A. Biland, T. Bretz, K. Bruegge, J. Buss, D. Dorner, D. Elsaesser, D. Hildebrand, R. Iotov, M. Klinger, K. Mannheim, D. Neise, A. Neronov, M. Noethe, A. Paravac, V. Sliusar, F. Theissen, R. Walter, J. Valverde, D. Horan, M. Giroletti, M. Perri, F. Verrecchia, C. Leto, A. C. Sadun, J. W. Moody, M. Joner, A. P. Marscher, S. G. Jorstad, A. Lahteenmaki, M. Tornikoski, V. Ramakrishnan, E. Jarvela, R. J. C. Vera, S. Righini, and A.Y.Lien
Subjects: Astronomy
Abstract: We report a characterization of the multiband flux variability and correlations of the nearby (z=0.031) blazar Markarian 421(Mrk 421) using data from Mets ̈ahovi, Swift, Fermi-LAT, MAGIC, FACT, and other collaborations and instruments from 2014November till 2016 June. Mrk 421 did not show any prominent flaring activity, but exhibited periods of historically low activity above 1 TeV (F>1TeV<1.7×10−12ph cm−2s−1) and in the 2–10 keV (X-ray) band (F2−10 keV<3.6×10−11erg cm−2s−1),during which the Swift-BAT data suggest an additional spectral component beyond the regular synchrotron emission. The highest flux variability occurs in X-rays and very high-energy (E>0.1 TeV)γ-rays, which, despite the low activity, show a significant positive correlation with no time lag. The HRkeV and HRTeV show the harder-when-brighter trend observed in many blazars, but the trend flattens at the highest fluxes, which suggests a change in the processes dominating the blazar variability. Enlarging our dataset with data from years 2007 to 2014, we measured a positive correlation between the optical and the GeV emission over a range of about 60 d centred at time lag zero, and a positive correlation between the optical/GeV and the radio emission over a range of about 60 d centred at a time lag of 43+9−6d. This observation is consistent with the radio-bright zone being located about 0.2 parsec downstream from the optical/GeV emission regions of the jet. The flux distributions are better described with a lognormal function in most of the energy bands probed, indicating that the variability in Mrk 421 is likely produced by a multiplicative process.
Published: 2020
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6. O envolvimento de genes e proteínas na regulação da apoptose – Carcinogênese

Author: Ana Bárbara M. Delfino, Emandes Campos Barreto, Edejar Teixeira da Silva Jr., Renato Gonçalves de Mendonça, and Maria Helena Ornellas
Subjects: General Engineering, General Earth and Planetary Sciences, General Environmental Science
Abstract: A apoptose é um fator importante em muitos processos biológicos normais, tais como a embriogênese, o desenvolvimento do sistema imune, a maturação e a diferenciação celular. Em situações patológicas, a apoptose parece estar implicada na imunodeficiência, resistência a drogas e carcinogênese. Sabe-se que a carcinogênese envolve alterações genéticas cumulativas em oncogenes e genes supressores de tumor. Dessa forma, o prognóstico de cada tumor humano parece depender do equilíbrio entre os diversos genes, sendo previsível que um conhecimento mais profundo da cooperação e antagonismo entre esses genes possa fornecer num futuro próximo informações clinicamente relevantes. Nós revisamos alguns dos mais recentes progressos a respeito de genes envolvidos na apoptose e nos cânceres humanos (p53, bcl-2, c-myc, fas-APO-l, mdr-1) e suas implicações clínicas.
Published: 2022

7. La Corte costituzionale e il licenziamento illegittimo nelle piccole imprese: una bussola per il legislatore?

Author: m. delfino and Delfino, M.
Published: 2023

8. Observation of inverse Compton emission from a long γ-ray burst

Author: P. Veres, P. N. Bhat, M. S. Briggs, W. H. Cleveland, R. Hamburg, C. M. Hui, B. Mailyan, R. D. Preece, O. J. Roberts, A. von Kienlin, C. A. Wilson-Hodge, D. Kocevski, M. Arimoto, D. Tak, K. Asano, M. Axelsson, G. Barbiellini, E. Bissaldi, F.Fana Dirirsa, R. Gill, J. Granot, J. McEnery, N. Omodei, S. Razzaque, F. Piron, J. L. Racusin, D. J. Thompson, S. Campana, M. G. Bernardini, N. P. M. Kuin, M. H. Siegel, S. B. Cenko, P. O’Brien, M. Capalbi, A. Daì, M. De Pasquale, J. Gropp, N. Klingler, J. P. Osborne, M. Perri, R. L. C. Starling, G. Tagliaferri, A. Tohuvavohu, A. Ursi, M.Tavani, M. Cardillo, C. Casentini, G. Piano, Y. Evangelista, F. Verrecchia, C. Pittori, F. Lucarelli, A. Bulgarelli, N. Parmiggiani, G. E. Anderson, J. P. Anderson, G. Bernardi, J. Bolmer, M. D. Caballero-García, I. M. Carrasco, A. Castellón, N. Castro Segura, A. J. Castro-Tirado, S. V. Cherukuri, A. M. Cockeram, P. D’Avanzo, A. Di Dato, R. Diretse, R. P. Fender, E. Fernández-García, J. P. U. Fynbo, A. S.Fruchter, J. Greiner, M. Gromadzki, K. E. Heintz, I. Heywood, A. J. van der Horst, Y.-D. Hu, C. Inserra, L. Izzo, V. Jaiswal, P. Jakobsson, J. Japelj, E. Kankare, D. A.Kann, C. Kouveliotou, S. Klose, A. J. Levan, X. Y. Li, S. Lotti, K. Maguire, D. B. Malesani, I. Manulis, M. Marongiu, S. Martin, A. Melandri, M. J.Michałowski, J. C. A. Miller-Jones, K. Misra, A. Moin, K. P. Mooley, S. Nasri, M. Nicholl, A. Noschese, G. Novara, S. B. Pandey, E. Peretti, C. J. Pérez del Pulgar, M. A. Pérez-Torres, D. A. Perley, L. Piro, F. Ragosta, L. Resmi, R. Ricci, A. Rossi, R. Sánchez-Ramírez, J. Selsing, S. Schulze, S. J. Smartt, I. A. Smith, V. V. Sokolov, J. Stevens, N. R. Tanvir, C. C. Thöne, A. Tiengo, E. Tremou, E. Troja, A. de Ugarte Postigo, A. F. Valeev, S. D. Vergani, M. Wieringa, P. A. Woudt, D. Xu, O. Yaron, D. R. Young, V. A. Acciari, S. Ansoldi, L. A. Antonelli, A. Arbet Engels, D. Baack, A. Babić, B. Banerjee, U. Barres de Almeida, J. A. Barrio, J. Becerra González, W. Bednarek, L. Bellizzi, E. Bernardini, A. Berti, J. Besenrieder, W. Bhattacharyya, C. Bigongiari, A. Biland, O. Blanch, G. Bonnoli, Ž. Bošnjak, G. Busetto, R. Carosi, G. Ceribella, Y. Chai, A. Chilingaryan, S. Cikota, S. M. Colak, U. Colin, E. Colombo, J. L. Contreras, J. Cortina, S. Covino, V. D’Elia, P. Da Vela, F. Dazzi, A. De Angelis, B. De Lotto, M. Delfino, J. Delgado, D. Depaoli, F. Di Pierro, L. Di Venere, E. Do Souto Espiñeira, D. Dominis Prester, A. Donini, D. Dorner, M. Doro, D. Elsaesser, V. Fallah Ramazani, A. Fattorini, G. Ferrara, D. Fidalgo, L. Foffano, M. V. Fonseca, L. Font, C. Fruck, S. Fukami, R. J. García López, M. Garczarczyk, S.Gasparyan, M. Gaug, N. Giglietto, F. Giordano, N. Godinović, D. Green, D. Guberman, D. Hadasch, A. Hahn, J. Herrera, J. Hoang, D. Hrupec, M. Hütten, T. Inada, S. Inoue, K. Ishio, Y. Iwamura, L. Jouvin, D. Kerszberg, H. Kubo, J. Kushida, A. Lamastra, D. Lelas, F. Leone, E. Lindfors, S. Lombardi, F. Longo, M. López, R. López-Coto, A. López-Oramas, S. Loporchio, B. Machado de Oliveira Fraga, C. Maggio, P. Majumdar, M. Makariev, M. Mallamaci, G. Maneva, M. Manganaro, K. Mannheim, L. Maraschi, M. Mariotti, M. Martínez, D. Mazin, S. Mićanović, D. Miceli, M. Minev, J. M. Miranda, R. Mirzoyan, E. Molina, A. Moralejo, D. Morcuende, V. Moreno, E. Moretti, P. Munar-Adrover, V. Neustroev, C. Nigro, K. Nilsson, D. Ninci, K. Nishijima, K. Noda, L. Nogués, S. Nozaki, S. Paiano, M. Palatiello, D. Paneque, R. Paoletti, J. M. Paredes, P. Peñil, M. Peresano, M. Persic, P. G. Prada Moroni, E. Prandini, I. Puljak, W. Rhode, M. Ribó, J. Rico, C. Righi, A. Rugliancich, L. Saha, N. Sahakyan, T. Saito, S. Sakurai, K. Satalecka, K. Schmidt, T. Schweizer, J. Sitarek, I. Šnidarić, D. Sobczynska, A. Somero, A. Stamerra, D. Strom, M. Strzys, Y. Suda, T. Surić, M. Takahashi, F. Tavecchio, P. Temnikov, T. Terzić, M. Teshima, N. Torres-Albà, L. Tosti, V. Vagelli, J. van Scherpenberg, G. Vanzo, M. Vazquez Acosta, C. F. Vigorito, V. Vitale, I. Vovk, M. Will, D. Zarić, and L. Nava
Subjects: Space Sciences (General)
Abstract: Long-duration γ-ray bursts (GRBs) originate from ultra-relativistic jets launched from the collapsing cores of dying massive stars. They are characterized by an initial phase of bright and highly variable radiation in the kiloelectronvolt-to-megaelectronvolt band, which is probably produced within the jet and lasts from milliseconds to minutes, known as the prompt emission. Subsequently, the interaction of the jet with the surrounding medium generates shock waves that are responsible for the afterglow emission, which lasts from days to months and occurs over a broad energy range from the radio to the gigaelectronvolt bands. The afterglow emission is generally well explained as synchrotron radiation emitted by electrons accelerated by the external shock. Recently, intense long-lasting emission between 0.2 and 1 teraelectronvolts was observed from GRB 190114C. Here we report multifrequency observations of GRB 190114C, and study the evolution in time of the GRB emission across 17 orders of magnitude in energy, from 5 × 10^(−6) to 10^(12) electronvolts. We find that the broadband spectral energy distribution is double-peaked, with the teraelectronvolt emission constituting a distinct spectral component with power comparable to the synchrotron component. This component is associated with the afterglow and is satisfactorily explained by inverse Compton up-scattering of synchrotron photons by high-energy electrons. We find that the conditions required to account for the observed teraelectronvolt component are typical for GRBs, supporting the possibility that inverse Compton emission is commonly produced in GRBs.
Published: 2019
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9. MAGIC and Fermi-LAT gamma-ray results on unassociated HAWC sources

Author: M. L. Ahnen, S. Ansoldi, L. A. Antonelli, C. Arcaro, D. Baack, A. Babic, B. Banerjee, P. Bangale, U. Barres de Almeida, J. A. Barrio, J. Becerra Gonzalez, W. Bednarek, E. Bernardini, R. Ch. Berse, A. Berti, W. Bhattacharyya, A. Biland, O. Blanch, G. Bonnoli, R. Carosi, A. Carosi, G. Ceribella, A. Chatterjee, S. M. Colak, P. Colin, E. Colombo, J. L. Contreras, J. Cortina, S. Covino, P. Cumani, P. Da Vela, F. Dazzi, A. De Angelis, B. De Lotto, M. Delfino, J. Delgado, F. Di Pierro, A. Domınguez, D. Dominis Prester, D. Dorner, M. Doro, S. Einecke, D. Elsaesser, V. Fallah Ramazani, A. Fernandez-Barral, D. Fidalgo, M. V. Fonseca, L. Font, C. Fruck, D. Galindo, R. J. Garcıa Lopez, M. Garczarczyk, M. Gaug, P. Giammaria, N. Godinovic, D. Gora, D. Guberman, D. Hadasch, A. Hahn, T. Hassan, M. Hayashida, J. Herrera, J. Hose, D. Hrupec, K. Ishio, Y. Konno, H. Kubo, J. Kushida, D. Kuvezdic, D. Lelas, E. Lindfors, S. Lombardi, F. Longo, M. Lopez, C. Maggio, P. Majumdar, M. Makariev, G. Maneva, M. Manganaro, K. Mannheim, L. Maraschi, M. Mariotti, M. Martınez, S. Masuda, D. Mazin, K. Mielke, M. Minev, J. M. Miranda, R. Mirzoyan, A. Moralejo, V. Moreno, E. Moretti, T. Nagayoshi, V. Neustroev, A. Niedzwiecki, M. Nievas Rosillo, C. Nigro, K. Nilsson, D. Ninci, K. Nishijima, K. Noda, L. Nogues, S. Paiano, J. Palacio, D. Paneque, R. Paoletti, J. M. Paredes, G. Pedaletti, M. Peresano, M. Persic, P. G. Prada Moroni, E. Prandini, I. Puljak, J. R. Garcia, I. Reichardt, W. Rhodes, M. Ribo, J. Rico, C. Righi, A. Rugliancich, T. Saito, K. Satalecka, T. Schweizer, J. Sitarek, I. Snidaric, D. Sobczynska, A. Stamerra, M. Strzys, T. Suric, M. Takahashi, L. Takalo, F. Tavecchio, P. Temnikov, T. Terzic, M. Teshima, N. Torres-Alba, A. Treves, S. Tsujimoto, G. Vanzo, M. Vazquez Acosta, I. Vovk, J. E. Ward, M. Will, D. Zaric, A. Albert, R. Alfaro, C. Alvarez, R. Arceo, J. C. Arteaga-Velazquez, D. Avila Rojas, H. A. Ayala Solares, A. Becerril, E. Belmont-Moreno, S. Y. BenZvi, A. Bernal, J. Braun, K. S. Caballero-Mora, T. Capistran, A. Carraminana, S. Casanova, M. Castillo, U. Cotti, J. Cotzomi, S. Coutino de Leon, C. De Leon, E. De la Fuente, R. Diaz Hernandez, S. Dichiara, B. L. Dingus, M. A. DuVernois, J. C. Dıaz-Velez, R. W. Ellsworth, K. Engel, O. Enriquez-Rivera, D. W. Fiorino, H. Fleischhack, N. Fraija, J. A. Garcıa-Gonzalez, F. Garfias, A. Gonzalez-Munoz, M. M. Gonzalez, J. A. Goodman, Z. Hampel-Arias, J. P. Harding, S. Hernandez, F. Hueyotl-Zahuantitla, C. M. Hui, P. Huntemeyer, A. Iriarte, A. Jardin-Blicq, V. Joshi, S. Kaufmann, A. Lara, R. J. Lauer, W. H. Lee, D. Lennarz, H. Leon Vargas, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, R. Luna-Garcıa, R. Lopez-Coto, K. Malone, S. S. Marinelli, O. Martinez, I. Martinez-Castellanos, J. Martınez-Castro, H. Martınez-Huerta, J. A. Matthews, P. Miranda-Romagnoli, E. Moreno, A. Nayerhoda, L. Nellen, M. Newbold, M. U. Nisa, R. Noriega-Papaqui, R. Pelayo, J. Pretz, E. G. Perez-Perez, Z. Ren, C. D. Rho, C. Riviere, D. Rosa-Gonzalez, M. Rosenberg, E. Ruiz-Velasco, F. Salesa Greus, A. Sandoval, M. Schneider, M. Seglar Arroyo, G. Sinnis, A. J. Smith, R. W. Springer, P. Surajbali, I. Taboada, O. Tibolla, K. Tollefson, I. Torres, T. N. Ukwatta, G. Vianello, L. Villasenor, F. Werner, S. Westerhoff, J. Wood, T. Yapici, G. Yodh, A. Zepeda, H. Zhou, J. D. Alvarez, M. Ajello, L. Baldini, G. Barbiellini, B. Berenji, E. Bissaldi, R. D. Blandford, R. Bonino, E. Bottacini, T. J. Brandt, J. Bregeon, P. Bruel, R. A. Cameron, R. Caputo, P. A. Caraveo, D. Castro, E. Cavazzuti, G. Chiaro, S. Ciprini, D. Costantin, F. D'Ammando, F. de Palma, A. Desai, N. Di Lalla, M. Di Mauro, L. Di Venere, C. Favuzzi, Y. Fukazawa, S. Funk, P. Fusco, F. Gargano, D. Gasparrini, N. Giglietto, F. Giordano, M. Giroletti, T. Glanzman, D. Green, I. A. Grenier, S. Guiriec, A. K. Harding, E. Hays, J. W. Hewitt, D. Horan, G. Johannesson, M. Kuss, S. Larsson, I. Liodakis, F. Loparco, P. Lubrano, J. D. Magill, S. Maldera, A. Manfreda, M. N. Mazziotta, I. Mereu, P. F. Michelson, T. Mizuno, M. E. Monzani, A. Morselli, I. V. Moskalenko, M. Negro, E. Nuss, N. Omodei, M. Orienti, E. Orlando, J. F. Ormes, M. Palatiello, V. S. Paliya, M. Pesce-Rollins, V. Petrosian, F. Piron, T. A. Porter, G. Principe, S. Raino, B. Rani, M. Razzano, S. Razzaque, A. Reimer, O. Reimer, C. Sgro, E. J. Siskind, G. Spandre, P. Spinelli, H. Tajima, J. B. Thayer, David J Thompson, D. F. Torres, E. Torresi, E. Troja, J. Valverde, K. Wood, and M. Yassine
Subjects: Astronomy, Astrophysics
Abstract: The HAWC Collaboration released the 2HWC catalogue of TeV sources, in which 19 show no association with any known high-energy (HE; E ≳ 10 GeV) or very-high-energy (VHE; E ≳ 300 GeV) sources. This catalogue motivated follow-up studies by both the Major Atmospheric Gamma-ray Imaging Cherenkov (MAGIC) and Fermi-LAT (Large Area Telescope) observatories with the aim of investigating gamma-ray emission over a broad energy band. In this paper, we report the results from the first joint work between High Altitude Water Cherenkov (HAWC), MAGIC, and Fermi-LAT on three unassociated HAWC sources: 2HWC J2006+341, 2HWC J1907+084*, and 2HWC J1852+013*. Although no significant detection was found in the HE and VHE regimes, this investigation shows that a minimum 1° extension (at 95 per cent confidence level) and harder spectrum in the GeV than the one extrapolated from HAWC results are required in the case of 2HWC J1852+013*, whilst a simply minimum extension of 0.16° (at 95 per cent confidence level) can already explain the scenario proposed by HAWC for the remaining sources. Moreover, the hypothesis that these sources are pulsar wind nebulae is also investigated in detail.
Published: 2019
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10. Diagnostic evaluation of syncope in a tertiary hospital in Metro Manila: a retrospective study

Author: Jean Paolo M. Delfino, MD and Anna Marie Sage-Nolido, MD, FPNA
Subjects: General Medicine
Published: 2022

11. Diagnostic evaluation of syncope in a tertiary hospital in Metro Manila: a retrospective study

Author: Paolo M. Delfino, MD, Jean, primary and Marie Sage-Nolido, MD, FPNA, Anna, additional
Published: 2022
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12. PICNIC - Portal-based Platform for MRI Processing of Neurodegenerative Diseases.

Author: J. Delgado-Mengual, Yolanda Vives-Gilabert, A. Sainz-Ruiz, M. Delfino-Reznicek, and B. Gómez-Ansón
Published: 2010

13. The Proposal for an EU Directive on adequate Minimum Wages and its impact on Italy

Author: M. Delfino and Delfino, M.
Subjects: minimum wages, Law in general. Comparative and uniform law. Jurisprudence, collective bargaining, statutory intervention, Labor. Work. Working class, K1-7720, HD4801-8943, eu competence
Abstract: This contribution aims to assess the effects on the Italian legal order of the proposed directive of the European Union on minimum wages. The approach adopted in the research was that of the legal-regulatory analysis of the provisions of the proposal and their effects on the Italian statutory and collective sources. The approval of the directive would require the Italian legislator to take transposition action even if it were not decided to introduce legislation on minimum wages. The research has the limit of placing a proposal for a directive at the centre of the investigation which is not known whether and in which version it will be approved but the contribution constitutes a useful tool available to the European and domestic legislators to understand the constraints and potential of regulatory intervention on the matter. The original features of the research are represented by the delimitation of the boundaries of the Union's competence in the field of remuneration and the interaction between the EU and Italian legal dimensions., Italian Labour Law e-Journal, Vol. 14 No. 1 (2021)
Published: 2021

14. Structural coalescence underlies the aggregation propensity of a β-barrel protein motif.

Author: Carla R Angelani, Julio J Caramelo, Lucrecia M Curto, and José M Delfino
Subjects: Medicine, Science
Abstract: A clear understanding of the structural foundations underlying protein aggregation is an elusive goal of central biomedical importance. A step toward this aim is exemplified by the β-barrel motif represented by the intestinal fatty acid binding protein (IFABP) and two abridged all-β sheet forms (Δ98Δ and Δ78Δ). At odds with the established notion that a perturbation of the native fold should necessarily favor a buildup of intermediate forms with an enhanced tendency to aggregate, the intrinsic stability (ΔG°H2O) of these proteins does not bear a straightforward correlation with their trifluoroethanol (TFE)-induced aggregation propensity. In view of this fact, we found it more insightful to delve into the connection between structure and stability under sub-aggregating conditions (10% TFE). In the absence of the co-solvent, the abridged variants display a common native-like region decorated with a disordered C-terminal stretch. Upon TFE addition, an increase in secondary structure content is observed, assimilating them to the parent protein. In this sense, TFE perturbs a common native like region while exerting a global compaction effect. Importantly, in all cases, fatty acid binding function is preserved. Interestingly, energetic as well as structural diversity in aqueous solution evolves into a common conformational ensemble more akin in stability. These facts reconcile apparent paradoxical findings related to stability and rates of aggregation. This scenario likely mimics the accrual of aggregation-prone species in the population, an early critical event for the development of fibrillation.
Published: 2017
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15. Clinical Validation of a Colorimetric Loop-Mediated Isothermal Amplification Using a Portable Device for the Rapid Detection of SARS-CoV-2

Author: Bruna W. Raddatz, Felipe J. Rabello, Rafael Benedetti, Gisleine J. Steil, Louise M. Imamura, Edson Y. S. Kim, Erika B. Santiago, Luís F. Hartmann, João V. Predebon, Bruna M. Delfino, Meri B. Nogueira, Jucélia S. dos Santos, Breno G. da Silva, Diego R. P. Nicollete, Bernardo M. M. de Almeida, Sergio R. Rogal, and Marcus V. M. Figueredo
Subjects: Clinical Biochemistry, RT-LAMP, colorimetric, SARS-CoV-2, Point-of-Care, diagnostics
Abstract: Quick and reliable mass testing of infected people is an effective tool for the contingency of SARS-CoV-2. During the COVID-19 pandemic, Point-of-Care (POC) tests using Loop-Mediated Isothermal Amplification (LAMP) arose as a useful diagnostic tool. LAMP tests are a robust and fast alternative to Polymerase Chain Reaction (PCR), and their isothermal property allows easy incorporation into POC platforms. The main drawback of using colorimetric LAMP is the reported short-term stability of the pre-mixed reagents, as well as the relatively high rate of false-positive results. Also, low-magnitude amplification can produce a subtle color change, making it difficult to discern a positive reaction. This paper presents Hilab Molecular, a portable device that uses the Internet of Things and Artificial Intelligence to pre-analyze colorimetric data. In addition, we established manufacturing procedures to increase the stability of colorimetric RT-LAMP tests. We show that ready-to-use reactions can be stored for up to 120 days at −20 °C. Furthermore, we validated both the Hilab Molecular device and the Hilab RT-LAMP test for SARS-CoV-2 using 581 patient samples without any purification steps. We achieved a sensitivity of 92.93% and specificity of 99.42% (samples with CT ≤ 30) when compared to RT-qPCR.
Published: 2023

16. La reinterpretazione del principio di sussidiarietà orizzontale nel diritto sociale europeo

Author: M. Delfino, AA.VV., and Delfino, M.
Published: 2022

17. Lo stato d’emergenza e le misure in tema di sospensione dal lavoro al tempo del Covid-19

Author: M. Delfino, A. Ciriello, M. Delfino, and Delfino, M.
Published: 2021

18. Amyloidogenic propensity of a natural variant of human apolipoprotein A-I: stability and interaction with ligands.

Author: Silvana A Rosú, Omar J Rimoldi, Eduardo D Prieto, Lucrecia M Curto, José M Delfino, Nahuel A Ramella, and M Alejandra Tricerri
Subjects: Medicine, Science
Abstract: A number of naturally occurring mutations of human apolipoprotein A-I (apoA-I) have been associated with hereditary amyloidoses. The molecular mechanisms involved in amyloid-associated pathology remain largely unknown. Here we examined the effects of the Arg173Pro point mutation in apoA-I on the structure, stability, and aggregation propensity, as well as on the ability to bind to putative ligands. Our results indicate that the mutation induces a drastic loss of stability, and a lower efficiency to bind to phospholipid vesicles at physiological pH, which could determine the observed higher tendency to aggregate as pro-amyloidogenic complexes. Incubation under acidic conditions does not seem to induce significant desestabilization or aggregation tendency, neither does it contribute to the binding of the mutant to sodium dodecyl sulfate. While the binding to this detergent is higher for the mutant as compared to wt apoA-I, the interaction of the Arg173Pro variant with heparin depends on pH, being lower at pH 5.0 and higher than wt under physiological pH conditions. We suggest that binding to ligands as heparin or other glycosaminoglycans could be key events tuning the fine details of the interaction of apoA-I variants with the micro-environment, and probably eliciting the toxicity of these variants in hereditary amyloidoses.
Published: 2015
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19. Zoledronate repositioning as a potential trypanocidal drug: Trypanosoma cruzi HPRT an alternative target to be considered

Author: S. H. Fernandez Villamil, W.M. Valsecchi, José M. Delfino, and Javier Santos
Subjects: 0301 basic medicine, Chagas disease, Hypoxanthine Phosphoribosyltransferase, Cell Survival, Trypanosoma cruzi, Drug resistance, Biology, Pharmacology, Biochemistry, Zoledronic Acid, purl.org/becyt/ford/1 [https], 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Farnesyl diphosphate synthase, Drug Delivery Systems, HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE (HPRT), BISPHOSPHONATES, ZOLEDRONATE, Chlorocebus aethiops, medicine, Animals, Humans, purl.org/becyt/ford/1.6 [https], Nucleotide salvage, Vero Cells, Bone Density Conservation Agents, GROWTH INHIBITION, Drug Repositioning, TRYPANOSOMA CRUZI, medicine.disease, biology.organism_classification, Trypanocidal Agents, 030104 developmental biology, chemistry, Hypoxanthine-guanine phosphoribosyltransferase, 030220 oncology & carcinogenesis, biology.protein, Growth inhibition
Abstract: Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and affects 7 million people worldwide. Considering the side effects and drug resistance shown by current treatments, the development of new anti-Chagas therapies is an urgent need. T. cruzi hypoxanthine phosphoribosyltransferase (TcHPRT), the key enzyme of the purine salvage pathway, is essential for the survival of trypanosomatids. Previously, we assessed the inhibitory effect of different bisphosphonates (BPs), HPRT substrate analogues, on the activity of the isolated enzyme. BPs are used as a treatment for bone diseases and growth inhibition studies on T. cruzi have associated BPs action with the farnesyl diphosphate synthase inhibition. Here, we demonstrated significant growth inhibition of epimastigotes in the presence of BPs and a strong correlation with our previous results on the isolated TcHPRT, suggesting this enzyme as a possible and important target for these drugs. We also found that the parasites exhibited a delay at S phase in the presence of zoledronate pointing out enzymes involved in the cell cycle, such as TcHPRT, as intracellular targets. Moreover, we validated that micromolar concentrations of zoledronate are capable to interfere with the progression of cell infection by this parasite. Altogether, our findings allow us to propose the repositioning of zoledronate as a promising candidate against Chagas disease and TcHPRT as a new target for future rational design of antiparasitic drugs. Fil: Valsecchi, Wanda Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina Fil: Delfino, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina Fil: Santos, Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina Fil: Fernandez Villamil, Silvia Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
Published: 2021

20. Peptides Derived From the α-Core and γ-Core Regions of a Putative Silybum marianum Flower Defensin Show Antifungal Activity Against Fusarium graminearum

Author: Agustina Fernández, María Laura Colombo, Lucrecia M. Curto, Gabriela E. Gómez, José M. Delfino, Fanny Guzmán, Laura Bakás, Ismael Malbrán, and Sandra E. Vairo-Cavalli
Subjects: Microbiology (medical), Fusarium, Biología, Antimicrobial peptides, lcsh:QR1-502, antifungal peptide design, Microbiology, lcsh:Microbiology, Antifungal peptides, Cell wall, Defensins, 03 medical and health sciences, chemistry.chemical_compound, Antifungal peptide design, antimicrobial peptides, Complementary DNA, Propidium iodide, Defensin, 030304 developmental biology, Original Research, fusarium head blight, 0303 health sciences, biology, 030306 microbiology, fungi, food and beverages, biology.organism_classification, Fusarium graminearum, Cell killing, Fusarium head blight, chemistry, Biochemistry, antifungal peptides, Cytoplasm, defensins
Abstract: Fusarium graminearum is the etiological agent of Fusarium head blight (FHB), a disease that produces a significant decrease in wheat crop yield and it is further aggravated by the presence of mycotoxins in the affected grains that may cause health problems to humans and animals. Plant defensins and defensin-like proteins are antimicrobial peptides (AMPs); they are small basic, cysteine-rich peptides (CRPs) ubiquitously expressed in the plant kingdom and mostly involved in host defence. They present a highly variable sequence but a conserved structure. The γ-core located in the C-terminal region of plant defensins has a conserved β-hairpin structure and is a well-known determinant of the antimicrobial activity among disulphide-containing AMPs. Another conserved motif of plant defensins is the α-core located in the N-terminal region, not conserved among the disulphide-containing AMPs, it has not been yet extensively studied. In this report, we have cloned the putative antimicrobial protein DefSm2, expressed in flowers of the wild plant Silybum marianum. The cDNA encodes a protein with two fused basic domains of an N-terminal defensin domain (DefSm2-D) and a C-terminal Arg-rich and Lys-rich domain. To further characterize the DefSm2-D domain, we built a 3D template-based model that will serve to support the design of novel antifungal peptides. We have designed four potential antifungal peptides: two from the DefSm2-D α-core region (SmAPα1-21 and SmAPα10-21) and two from the γ-core region (SmAPγ27-44 and SmAPγ29-35). We have chemically synthesized and purified the peptides and further characterized them by electrospray ionization mass spectrometry (ESI-MS) and Circular dichroism (CD) spectroscopy. SmAPα1-21, SmAPα10-21, and SmAPγ27-44 inhibited the growth of the phytopathogen F. graminearum at low micromolar concentrations. Conidia exposure to the fungicidal concentration of the peptides caused membrane permeabilization to the fluorescent probe propidium iodide (PI), suggesting that this is one of the main contributing factors in fungal cell killing. Furthermore, conidia treated for 0.5h showed cytoplasmic disorganization as observed by transmission electron microscopy (TEM). Remarkably, the peptides derived from the α-core induced morphological changes on the conidia cell wall, which is a promising target since its distinctive biochemical and structural organization is absent in plant and mammalian cells., Centro de Investigación de Proteínas Vegetales, Centro de Investigaciones en Fitopatología
Published: 2021

21. The Great Transformation

Author: G. Gernez, Elena Maini, H.-P. Uerpmann, M. Cattani, D. Frenez, S. Salvatori, M. Delfino, M. Buta, Eugenio Bortolini, M. Uerpmann, M. Lemée, V.M. Azzarà, R.W. Law, Antonio Curci, M. Carletti, O. Munoz, F. Borgi, S. Scaruffi, C. Giardino, Jonathan Mark Kenoyer, F. Cavulli, J. Frazier, and V. Charpentier
Subjects: Algebra, Computer science, Transformation (music)
Published: 2021

22. Transrectal needle ablation in the genitourinary tract: description of a novel technique

Author: R. S. Morais Neto, Tibana, Tiago Kojun, A. Arao Filho, B. M. Delfino, Inchingolo, Riccardo, Da Motta Leal Filho, Joaquim Mauricio, and Thiago Franchi Nunes
Published: 2021
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23. Brevi riflessioni sull’art. 19 Stat. Lav. nella prospettiva de iure condito

Author: M. Delfino and Delfino, M.
Published: 2021

24. Il distacco transnazionale dei lavoratori nel prisma del bilanciamento degli interessi

Author: M. Delfino and Delfino, M.
Published: 2021

25. La didattica a distanza fra insicurezze e potenzialità

Author: M. Delfino and Delfino, M.
Subjects: Didattica a distanza, didattica in presenza, didattica mista, diseguaglianze, sicurezza sul lavoro
Abstract: 1. La DaD nelle Università al tempo del Covid-19: un problema globale. 2. La DaD come generatore di diseguaglianze e di (qualche) opportunità. 3. Una Dad, mille DaD. 4. L'approccio dell'Università di Napoli Federico II: il potenziamento degli strumenti già esi-stenti. 5. Segue. La didattica blended fra bilanci e prospettive. 6. Spunti giuslavoristici: la sicurezza degli smart teachers e degli smart students.
Published: 2021

26. Proposta di direttiva, tutela giuridica dei salari e nodi della contrattazione collettiva in Italia

Author: M. Delfino and Delfino, M.
Subjects: Salari minimi, competenza Stati/UE, contrattazione collettiva, intervento legale
Abstract: Obiettivi: Il contributo si propone di valutare gli effetti sull’ordinamento italiano della proposta di direttiva dell’Unione europea in tema di salario minimo. Metodologia: L'approccio adottato nella ricerca è stato quello dell’analisi giuridico-normativa delle previsioni della proposta e dei loro effetti sulle fonti legali e collettive interne. Risultati: L’approvazione della direttiva imporrebbe un intervento attuativo del legislatore italiano anche nel caso in cui non si decidesse di introdurre una legislazione sui minimi salariali. Limiti e implicazioni: La ricerca presenta il limite di mettere al centro dell’indagine una proposta di direttiva che non è dato sapere se e in quale versione sarà approvata ma costituisce un utile strumento a disposizione del legislatore europeo e di quello interno per comprendere i vincoli e le potenzialità di un intervento normativo in materia. Originalità: I tratti originali della ricerca sono rappresentati dalla delimitazione dei confini della competenza dell’Unione in materia retributiva e dall’interazione fra la dimensione europea e quella italiana.
Published: 2021

27. La qualificazione del rapporto di lavoro nella platform economy. Riflessioni a partire dalle sentenze Uber

Author: M. Delfino, Fabozzi, Sigillò Massara, and Delfino, M.
Published: 2021

28. La tutela della salute nel diritto dell’Unione europea

Author: M. Delfino and Delfino, M.
Published: 2021

29. Author Correction: Proton acceleration in thermonuclear nova explosions revealed by gamma rays

Author: V. A. Acciari, S. Ansoldi, L. A. Antonelli, A. Arbet Engels, M. Artero, K. Asano, D. Baack, A. Babić, A. Baquero, U. Barres de Almeida, J. A. Barrio, I. Batković, J. Becerra González, W. Bednarek, L. Bellizzi, E. Bernardini, M. Bernardos, A. Berti, J. Besenrieder, W. Bhattacharyya, C. Bigongiari, A. Biland, O. Blanch, H. Bökenkamp, G. Bonnoli, Ž. Bošnjak, G. Busetto, R. Carosi, G. Ceribella, M. Cerruti, Y. Chai, A. Chilingarian, S. Cikota, S. M. Colak, E. Colombo, J. L. Contreras, J. Cortina, S. Covino, G. D’Amico, V. D’Elia, P. Da Vela, F. Dazzi, A. De Angelis, B. De Lotto, A. Del Popolo, M. Delfino, J. Delgado, C. Delgado Mendez, D. Depaoli, F. Di Pierro, L. Di Venere, E. Do Souto Espiñeira, D. Dominis Prester, A. Donini, D. Dorner, M. Doro, D. Elsaesser, V. Fallah Ramazani, L. Fariña Alonso, A. Fattorini, M. V. Fonseca, L. Font, C. Fruck, S. Fukami, Y. Fukazawa, R. J. García López, M. Garczarczyk, S. Gasparyan, M. Gaug, N. Giglietto, F. Giordano, P. Gliwny, N. Godinović, J. G. Green, D. Green, D. Hadasch, A. Hahn, T. Hassan, L. Heckmann, J. Herrera, J. Hoang, D. Hrupec, M. Hütten, T. Inada, K. Ishio, Y. Iwamura, I. Jiménez Martínez, J. Jormanainen, L. Jouvin, D. Kerszberg, Y. Kobayashi, H. Kubo, J. Kushida, A. Lamastra, D. Lelas, F. Leone, E. Lindfors, L. Linhoff, S. Lombardi, F. Longo, R. López-Coto, M. López-Moya, A. López-Oramas, S. Loporchio, B. Machado de Oliveira Fraga, C. Maggio, P. Majumdar, M. Makariev, M. Mallamaci, G. Maneva, M. Manganaro, K. Mannheim, L. Maraschi, M. Mariotti, M. Martínez, A. Mas Aguilar, D. Mazin, S. Menchiari, S. Mender, S. Mićanović, D. Miceli, T. Miener, J. M. Miranda, R. Mirzoyan, E. Molina, A. Moralejo, D. Morcuende, V. Moreno, E. Moretti, T. Nakamori, L. Nava, V. Neustroev, M. Nievas Rosillo, C. Nigro, K. Nilsson, K. Nishijima, K. Noda, S. Nozaki, Y. Ohtani, T. Oka, J. Otero-Santos, S. Paiano, M. Palatiello, D. Paneque, R. Paoletti, J. M. Paredes, L. Pavletić, P. Peñil, M. Persic, M. Pihet, P. G. Prada Moroni, E. Prandini, C. Priyadarshi, I. Puljak, W. Rhode, M. Ribó, J. Rico, C. Righi, A. Rugliancich, N. Sahakyan, T. Saito, S. Sakurai, K. Satalecka, F. G. Saturni, B. Schleicher, K. Schmidt, T. Schweizer, J. Sitarek, I. Šnidarić, D. Sobczynska, A. Spolon, A. Stamerra, J. Strišković, D. Strom, M. Strzys, Y. Suda, T. Surić, M. Takahashi, R. Takeishi, F. Tavecchio, P. Temnikov, T. Terzić, M. Teshima, L. Tosti, S. Truzzi, A. Tutone, S. Ubach, J. van Scherpenberg, G. Vanzo, M. Vazquez Acosta, S. Ventura, V. Verguilov, C. F. Vigorito, V. Vitale, I. Vovk, M. Will, C. Wunderlich, T. Yamamoto, D. Zarić, F. Ambrosino, M. Cecconi, G. Catanzaro, C. Ferrara, A. Frasca, M. Munari, L. Giustolisi, J. Alonso-Santiago, M. Giarrusso, U. Munari, and P. Valisa
Subjects: Astronomy and Astrophysics
Published: 2022

30. Author Correction: Global Implications of Local Unfolding Phenomena, Probed by Cysteine Reactivity in Human Frataxin

Author: Santiago Enrique Faraj, José M. Delfino, Martín Ezequiel Noguera, and Javier Santos
Subjects: Multidisciplinary, biology, Chemistry, lcsh:R, Frataxin, biology.protein, lcsh:Medicine, lcsh:Q, Reactivity (chemistry), Computational biology, lcsh:Science, Cysteine
Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Published: 2020

31. La reinterpretazione del principio di sussidiarietà orizzontale nel diritto sociale europeo

Author: M. Delfino and Delfino, M.
Published: 2020

32. VHE gamma-ray detection of FSRQ QSO B1420+326 and modeling of its enhanced broadband state in 2020

Author: Yu. V. Troitskaya, D. Zarić, M. I. Martínez, Svetlana G. Jorstad, J. Becerra González, Stefano Ansoldi, P. Peñil, D. Miceli, T. S. Grishina, Pullur Anil Kumar, Markus Gaug, Stefano Truzzi, A. De Angelis, D. Dorner, Alice Donini, G. Vanzo, L. A. Antonelli, Y. Suda, C. C. Cheung, J. van Scherpenberg, Fabrizio Tavecchio, Abelardo Moralejo, S. Lombardi, Francesco Longo, A. Babić, Elina Lindfors, Antonio Stamerra, D. Hadasch, Valeri M. Larionov, Petar Temnikov, Luigi Pacciani, Andrea Marchini, M. Orienti, B. Machado de Oliveira Fraga, E. Moretti, D. Depaoli, A. Porras, Kyoshi Nishijima, L. Bellizzi, Alan P. Marscher, R. J. C. Vera, Tjark Miener, M.K. Hallum, G. Maneva, M. Mariotti, Koji Noda, Elisa Bernardini, Yosuke Kobayashi, W. Bhattacharyya, Marco Berton, V. Fallah Ramazani, John Hoang, Stefano Ciprini, K. Mannheim, S. Mićanović, Alexander Kurtenkov, Alessia Spolon, P. Prajapati, I. Vovk, C. Maggio, S. M. Colak, Anne Lähteenmäki, A. Hahn, David H. Green, Matteo Cerruti, E. Molina, T. Surić, M. Minev, Simone Mender, D. Elsaesser, A. Rugliancich, T. Saito, M. Makariev, C. Perennes, K. Nilsson, G. Ceribella, Christian Fruck, W. Rhode, R. Carosi, V. A. Acciari, R. J. García López, Maria-Isabel Bernardos, Walter Max-Moerbeck, M. Hart, D. Paneque, Daria A. Morozova, D. Dominis Prester, Razmik Mirzoyan, Ciro Bigongiari, F. Giordano, Z. R. Weaver, J. Besenrieder, Damir Lelas, Oscar Blanch, F. Leone, J. Rico, Daniel Kerszberg, M. Will, B. De Lotto, Elisa Prandini, F. Di Pierro, Jenni Jormanainen, T. Schweizer, R. López-Coto, M. Vazquez Acosta, Pratik Majumdar, Giacomo D'Amico, A. Arbet Engels, Lea Heckmann, M. Karjalainen, Y. Kajiwara, L. Di Venere, Vitaly Neustroev, A. A. Vasilyev, S. Nozaki, D. Ninci, Elena G. Larionova, G. A. Borman, M. V. Fonseca, Rodrigo Reeves, W. Bednarek, Katsuaki Asano, R. Angioni, Dorota Sobczyńska, J. Herrera, Andrés Baquero, S. Paiano, Luca Tosti, Juan Abel Barrio, Chiara Righi, T. J. Pearson, M. Hodges, L. Jouvin, Joni Tammi, Dominik Baack, Shashikiran Ganesh, S. Fukami, Sebastian Kiehlmann, K. Ishio, G. Ferrara, Ashot Chilingarian, Antonio Tutone, J. Kushida, Narek Sahakyan, G. Bonnoli, Jose Luis Contreras, Y. Chai, M. Palatiello, Valerio D'Elia, Jarred Gershon Green, V. Verguilov, I. Puljak, A. López-Oramas, U. Barres de Almeida, Filippo D'Ammando, D. Strom, J. Otero-Santos, E. Colombo, Nikola Godinovic, Juan Cortina, Jose Miguel Miranda, Chaitanya Priyadarshi, I. Šnidarić, Dario Hrupec, R. Paoletti, A. Fattorini, Sergey S. Savchenko, Francesco Dazzi, Shunsuke Sakurai, Y. Iwamura, A. Berti, M. Teshima, M. Mallamaci, S. Ventura, M. Takahashi, Massimo Persic, J. M. Paredes, Markus Garczarczyk, M. Delfino, Vincenzo Vitale, G. Busetto, Tomohiko Oka, S. Gasparyan, Lab Saha, A. Lamastra, G. Escobedo, E. Recillas, F.G. Saturni, Hidetoshi Kubo, Jordi Delgado, Tomohiro Inada, S. Loporchio, Carlo Vigorito, S. Cikota, Susumu Inoue, Kevin Schmidt, Talvikki Hovatta, Ž. Bošnjak, Manuel Artero, M. López-Moya, Anthony C. S. Readhead, A. A. Nikiforova, Lovro Pavletić, Laura Maraschi, Pawel Gliwny, Nicola Giglietto, L. Font, E. Do Souto Espiñeira, Tomislav Terzić, C. Nigro, Luca Foffano, Julian Sitarek, E. N. Kopatskaya, Yoshiki Ohtani, N. Torres-Albà, C. Delgado Mendez, M. Strzys, Bernd Schleicher, Marina Manganaro, P. G. Prada Moroni, Merja Tornikoski, Konstancja Satalecka, D. Mazin, Michele Doro, Stefano Covino, Ivan S. Troitsky, A. Biland, L. Carrasco, P. Da Vela, M. Ribó, D. Morcuende, V. Moreno, Moritz Hütten, University of La Laguna, University of Udine, National Institute for Astrophysics, Swiss Federal Institute of Technology Zurich, Institute for High Energy Physics, The University of Tokyo, Dortmund University, University of Zagreb, Complutense University, Centro Brasileiro de Pesquisas Físicas, University of Łódź, University of Siena, German Electron Synchrotron, University of Padova, University of Turin, Max Planck Institute for Physics, University of Pisa, University of Barcelona, A. Alikhanian Yerevan Institute of Physics, CIEMAT, Polytechnic University of Bari, University of Rijeka, University of Würzburg, University of Turku, Autonomous University of Barcelona, National Academy of Sciences of the Republic of Armenia, University of Split, Josip Juraj Strossmayer University of Osijek, Kyoto University, Tokai University, Saha Institute of Nuclear Physics, Bulgarian Academy of Sciences, University of Oulu, Ruder Boskovic Institute, National Institute for Nuclear Physics, University of Rome Tor Vergata, ASI Science Data Center, Istituto di Astrofisica Spaziale e Fisica Cosmica di Bologna, Naval Research Laboratory, Physical Research Laboratory India, Instituto Nacional de Astrofisica Optica y Electronica, Metsähovi Radio Observatory, Boston University, St. Petersburg State University, Crimean Astrophysical Observatory, California Institute of Technology, Foundation for Research and Technology - Hellas, Universidad de Chile, Universidad de Concepción, Department of Electronics and Nanoengineering, Aalto-yliopisto, Aalto University, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Artero, M., Asano, K., Baack, D., Babi??, A., Baquero, A., Barres de Almeida, U., Barrio, J. A., Becerra Gonz??lez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bo??njak, ??., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D???amico, G., D???elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espi??eira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Ferrara, G., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Garc??a L??pez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinovi??, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., H??tten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jormanainen, J., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., L??pez-Coto, R., L??pez-Moya, M., L??pez-Oramas, A., Loporchio, S., Machado de Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Mart??nez, M., Mazin, D., Mender, S., Mi??anovi??, S., Miceli, D., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavleti??, L., Pe??il, P., Perennes, C., Persic, M., Prada Moroni, P. G., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Rib??, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., nidari??, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suri??, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzi??, T., Teshima, M., Torres-Alb??, N., Tosti, L., Truzzi, S., Tutone, A., van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Zari??, D., Angioni, R., D???ammando, F., Ciprini, S., Cheung, C. C., Orienti, M., Pacciani, L., Prajapati, P., Kumar, P., Ganesh, S., Kurtenkov, A., Marchini, A., Carrasco, L., Escobedo, G., Porras, A., Recillas, E., L??hteenm??ki, A., Tornikoski, M., Berton, M., Tammi, J., Vera, R. J. C., Jorstad, S. G., Marscher, A. P., Weaver, Z. R., Hart, M., Hallum, M. K., Larionov, V. M., Borman, G. A., Grishina, T. S., Kopatskaya, E. N., Larionova, E. G., Nikiforova, A. A., Morozova, D. A., Savchenko, S. S., Troitskaya, Yu. V., Troitsky, I. S., Vasilyev, A. A., Hodges, M., Hovatta, T., Kiehlmann, S., Max-Moerbeck, W., Readhead, A. C. S., Reeves, R., and Pearson, T. J.
Subjects: Radiation mechanisms: non-thermal, individual: QSO B1420+326 [quasars], Astrophysics::High Energy Astrophysical Phenomena, jets [galaxies], FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, gamma rays: galaxies, galaxies: jets, radiation mechanisms: non-thermal, quasars: individual: QSO B1420+326, law.invention, law, 0103 physical sciences, Galaxies: jets, Gamma rays: galaxies, Quasars: individual: QSO B1420+326, galaxie [gamma rays], Blazar, Spectroscopy, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Superluminal motion, 010308 nuclear & particles physics, Astronomy and Astrophysics, Optical polarization, Quasar, non-thermal [radiation mechanisms], galaxies, Astrophysics - High Energy Astrophysical Phenomena [gamma rays], jet [galaxies], Space and Planetary Science, galaxies [gamma rays], Spectral energy distribution, ddc:520, Física nuclear, Astrophysics - High Energy Astrophysical Phenomena, Equivalent width, Flare
Abstract: Astronomy and astrophysics 647, A163 (2021). doi:10.1051/0004-6361/202039687, Context. QSO B1420+326 is a blazar classified as a flat-spectrum radio quasar (FSRQ). At the beginning of the year 2020, it was found to be in an enhanced flux state and an extensive multiwavelength campaign allowed us to trace the evolution of the flare.Aims. We search for very high-energy (VHE) gamma-ray emission from QSO B1420+326 during this flaring state. We aim to characterize and model the broadband emission of the source over different phases of the flare.Methods. The source was observed with a number of instruments in radio, near-infrared, optical (including polarimetry and spectroscopy), ultraviolet, X-ray, and gamma-ray bands. We use dedicated optical spectroscopy results to estimate the accretion disk and the dust torus luminosity. We performed spectral energy distribution modeling in the framework of combined synchrotron-self-Compton and external Compton scenario in which the electron energy distribution is partially determined from acceleration and cooling processes.Results. During the enhanced state, the flux of both SED components of QSO B1420+326 drastically increased and the peaks were shifted to higher energies. Follow-up observations with the MAGIC telescopes led to the detection of VHE gamma-ray emission from this source, making it one of only a handful of FSRQs known in this energy range. Modeling allows us to constrain the evolution of the magnetic field and electron energy distribution in the emission region. The gamma-ray flare was accompanied by a rotation of the optical polarization vector during a low -polarization state. Also, a new superluminal radio knot contemporaneously appeared in the radio image of the jet. The optical spectroscopy shows a prominent FeII bump with flux evolving together with the continuum emission and a MgII line with varying equivalent width.Key words: gamma rays: galaxies / galaxies: jets / radiation mechanisms: non-thermal / quasars: individual: QSO B1420+326�� Corresponding authors; contact.magic@mpp.mpg.de�� Deceased., Published by EDP Sciences, Les Ulis
Published: 2020
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33. Testing two-component models on very high-energy gamma-ray-emitting BL Lac objects

Author: Razmik Mirzoyan, D. Ninci, Susumu Inoue, Dorota Sobczyńska, V. Verguilov, Chiara Righi, J. van Scherpenberg, I. Šnidarić, John Hoang, Y. Chai, Stefano Covino, A. Babić, F. Di Pierro, D. Strom, Jose Luis Contreras, Petar Temnikov, Elisa Bernardini, C. Arcaro, Y. Iwamura, Ž. Bošnjak, Juan Cortina, Andrei Berdyugin, Bernd Schleicher, L. Jouvin, M. Makariev, Massimo Persic, P. Peñil, Markus Garczarczyk, Antonio Stamerra, J. Becerra González, F. de Palma, A. Arbet Engels, F. Leone, B. Machado de Oliveira Fraga, L. Nogués, Juan Abel Barrio, Sebastian Kiehlmann, A. Rugliancich, Marina Manganaro, S. Ansoldi, J. Rico, Anthony C. S. Readhead, M. Palatiello, H. Kubo, M. Karjalainen, Vitaly Neustroev, Laura Maraschi, Pawel Gliwny, Tomohiro Inada, N. Godinović, Giacomo Bonnoli, L. Bellizzi, Narek Sahakyan, M. Vazquez Acosta, Nicola Giglietto, P. G. Prada Moroni, K. Mannheim, M. Takahashi, Luca Tosti, S. Loporchio, D. Dominis Prester, Miguel Nievas-rosillo, Francesco Giordano, U. Barres de Almeida, C. Nigro, Valerio D'Elia, J. Otero-Santos, M. I. Martínez, Francesco Dazzi, Simone Mender, Alessia Spolon, G. Maneva, D. Hadasch, Elina Lindfors, Konstancja Satalecka, Luca Foffano, R. J. García López, Jenni Jormanainen, Michele Doro, A. Hahn, Takeshi Oka, Rumen Bachev, Kyoshi Nishijima, Daniel Mazin, A. Berti, A. Donini, B. Banerjee, T. Schweizer, Kari Nilsson, K. Noda, Armin Nabizadeh, G. Busetto, Shunsuke Sakurai, Daniel Kerszberg, M. Will, S. Gasparyan, A. Lamastra, M. Delfino, P. Munar-Adrover, A. López-Oramas, V. Fallah Ramazani, Carlo Vigorito, L. Saha, M. Mariotti, Walter Max-Moerbeck, N. Torres-Albà, Sarah M. Wagner, David Paneque, A. Biland, F. D' Ammando, Anton Strigachev, J. Besenrieder, M. Hütten, I. Vovk, C. Maggio, Arto Oksanen, L. Pavletić, D. Elsaesser, Matteo Cerruti, S. Fukami, Christian Fruck, U. Colin, David A. Green, D. Lelas, Kazuma Ishio, V. A. Acciari, W. Bhattacharyya, Yosuke Kobayashi, A. Fattorini, R. Reinthal, D. Zarić, Seiya Nozaki, E. Do Souto Espiñeira, Tomislav Terzić, Y. Kajiwara, Julian Sitarek, A. De Angelis, D. Miceli, M. V. Fonseca, W. Rhode, Francesco Longo, S. Lombardi, B. De Lotto, Roberto Carosi, Elisa Prandini, Sofia Ventura, D. Morcuende, N. Talebpour Sheshvan, W. Bednarek, Saša Mićanović, M. Minev, Riccardo Paoletti, M. Teshima, S. M. Colak, Markus Gaug, M. Peresano, Yoshiki Ohtani, Jordi Delgado, J. Kushida, P. Kehusmaa, Oscar Blanch, Ashot Chilingarian, D. Dorner, L. A. Antonelli, L. O. Takalo, V. Moreno, Giacomo D'Amico, S. Cikota, Kevin Schmidt, Y. Suda, Talvikki Hovatta, Fabrizio Tavecchio, Rodrigo Reeves, Eduardo Colombo, Ll. Font, M. Hodges, G. Ferrara, Dario Hrupec, M. A. Lopez, G. Ceribella, J. M. Paredes, Ciro Bigongiari, M. Mallamaci, R. López-Coto, Abelardo Moralejo, E. Moretti, D. Depaoli, Edgar Molina, G. Vanzo, T. Saito, P. Majumdar, Jose Carlos Herrera, F. Wierda, M. Strzys, L. Di Venere, Vincenzo Vitale, Dominik Baack, Jose Miguel Miranda, Tjark Miener, T. Surić, P. Da Vela, M. Ribó, I. Puljak, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Baack, D., Babic, A., Banerjee, B., Barres De Almeida, U., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bosnjak, A., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espineira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Ferrara, G., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Garcia Lopez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinovic, N., Green, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Hutten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lopez-Coto, R., Lopez-Oramas, A., Loporchio, S., MacHado De Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Mazin, D., Mender, S., Micanovic, S., Miceli, D., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletic, L., Penil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suric, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Torres-Alba, N., Tosti, L., Van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Zaric, D., Nievas-Rosillo, M., Arcaro, C., D' Ammando, F., De Palma, F., Hodges, M., Hovatta, T., Kiehlmann, S., Max-Moerbeck, W., Readhead, A. C. S., Reeves, R., Takalo, L., Reinthal, R., Jormanainen, J., Wierda, F., Wagner, S. M., Berdyugin, A., Nabizadeh, A., Talebpour Sheshvan, N., Oksanen, A., Bachev, R., Strigachev, A., Kehusmaa, P., 30588766 - Arcaro, Cornelia, Academy of Finland, Ministerio de Economía y Competitividad (España), Swiss National Science Foundation, European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Japan Society for the Promotion of Science, Metsähovi Radio Observatory, Aalto-yliopisto, and Aalto University
Subjects: galaxies [Gamma rays], Astronomical databases: miscellaneous, BL Lacertae objects: general, Galaxies: Active, Galaxies: jets, Gamma rays: galaxies, Radiation mechanisms: non-Thermal, SHEATH POLARIZATION STRUCTURES, Astrophysics, Parameter space, galaxies: active, galaxies: jets, astronomical databases: miscellaneous, radiation mechanisms: non-thermal, gamma rays: galaxies, 01 natural sciences, jet [Galaxies], non-Thermal [Radiation mechanisms], 010303 astronomy & astrophysics, LACERTAE OBJECTS, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, TEV BLAZARS, CROSS-CORRELATIONS, galaxie [Gamma rays], 1ES 1959+650, Gamma ray, Active [Galaxies], miscellaneous [Astronomical databases], Spectral energy distribution, Física nuclear, RELATIVISTIC JETS, Astrophysics - High Energy Astrophysical Phenomena, ACTIVE GALACTIC NUCLEI, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Context (language use), Astrophysics::Cosmology and Extragalactic Astrophysics, GeneralLiterature_MISCELLANEOUS, 0103 physical sciences, Very-long-baseline interferometry, Blazar, MULTIWAVELENGTH OBSERVATIONS, 010308 nuclear & particles physics, general [BL Lacertae objects], ComputingMilieux_PERSONALCOMPUTING, Astronomy and Astrophysics, Light curve, Space and Planetary Science, X-RAY, ddc:520, jets [Galaxies], miscellaneou [Astronomical databases], COMPLETE SAMPLE, Free parameter
Abstract: MAGIC Collaboration: et al., [Context]: It has become evident that one-zone synchrotron self-Compton models are not always adequate for very high-energy (VHE) gamma-ray-emitting blazars. While two-component models perform better, they are difficult to constrain due to the large number of free parameters., [Aims]: In this work, we make a first attempt at taking into account the observational constraints from very long baseline interferometry (VLBI) data, long-term light curves (radio, optical, and X-rays), and optical polarisation to limit the parameter space for a two-component model and test whether or not it can still reproduce the observed spectral energy distribution (SED) of the blazars., [Methods]: We selected five TeV BL Lac objects based on the availability of VHE gamma-ray and optical polarisation data. We collected constraints for the jet parameters from VLBI observations. We evaluated the contributions of the two components to the optical flux by means of decomposition of long-term radio and optical light curves as well as modelling of the optical polarisation variability of the objects. We selected eight epochs for these five objects based on the variability observed at VHE gamma rays, for which we constructed the SEDs that we then modelled with a two-component model., [Results]: We found parameter sets which can reproduce the broadband SED of the sources in the framework of two-component models considering all available observational constraints from VLBI observations. Moreover, the constraints obtained from the long-term behaviour of the sources in the lower energy bands could be used to determine the region where the emission in each band originates. Finally, we attempt to use optical polarisation data to shed new light on the behaviour of the two components in the optical band. Our observationally constrained two-component model allows explanation of the entire SED from radio to VHE with two co-located emission regions., VFR and EL were supported by Academy of Finland projects 317636 and 320045. We would like to thank the Instituto de Astrofísica de Canarias for the excellent working conditions at the Observatorio del Roque de los Muchachos in La Palma. The financial support of the German BMBF and MPG; the Italian INFN and INAF; the Swiss National Fund SNF; the ERDF under the Spanish MINECO (FPA2017-87859-P, FPA2017-85668-P, FPA2017-82729-C6-2-R, FPA2017-82729-C6-6-R, FPA2017-82729-C6-5-R, AYA2015-71042-P, AYA2016-76012-C3-1-P, ESP2017-87055-C2-2-P, FPA2017-90566-REDC); the Indian Department of Atomic Energy; the Japanese ICRR, the University of Tokyo, JSPS, and MEXT; the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-268/16.12.2019 and the Academy of Finland grant nr. 320045 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2016-0588 and SEV2015-0548, the Unidad de Excelencia “María de Maeztu” MDM-2014-0369 and the “la Caixa” Foundation (fellowship LCF/BQ/PI18/11630012), by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3, the Polish National Research Centre grant UMO2016/22/M/ST9/00382 and by the Brazilian MCTIC, CNPq and FAPERJ.
Published: 2020

34. New Hard-TeV Extreme Blazars Detected with the MAGIC Telescopes*

Author: D. Fidalgo, K. Nishijima, R. Mirzoyan, B. Machado de Oliveira Fraga, P. Majumdar, P. Temnikov, L. Bellizzi, H. Kubo, M. Vazquez Acosta, M. I. Martínez, B. De Lotto, D. Dominis Prester, S. Paiano, I. Šnidarić, C. Nigro, Y. Iwamura, A. Carosi, Stefano Covino, M. Makariev, Alice Donini, A. Rugliancich, P. Munar-Adrover, G. Vanzo, Satoshi Fukami, John Hoang, Massimo Persic, J. Becerra González, Kazuma Ishio, T. Saito, S. Ansoldi, M. Palatiello, V. Fallah Ramazani, Jordi Delgado, C. Maggio, M. Delfino, S. Gasparyan, Elisa Prandini, Francesco Dazzi, Saverio Lombardi, A. Lamastra, Saša Mićanović, A. Berti, V. Vitale, J. Kushida, Kari Nilsson, Dario Hrupec, D. Lelas, A. Arbet Engels, M. Mallamaci, L. Maraschi, Elisa Bernardini, Fabrizio Tavecchio, P. Peñil, Vitaly Neustroev, Elina Lindfors, Ll. Font, M. Peresano, K. Noda, U. Colin, N. Godinović, Mitsunari Takahashi, E. Molina, David Paneque, A. Biland, W. Bednarek, W. Bhattacharyya, A. Fattorini, Ž. Bošnjak, M. Will, Anne M. Lohfink, A. Somero, Luca Tosti, Antonio Stamerra, P. Da Vela, C. Fruck, F. D'Ammando, D. Guberman, Katsuaki Asano, K. Mannheim, R. Carosi, M. Minev, Francesco Longo, Jose Luis Contreras, M. Teshima, A. Hahn, R. J. García López, G. Maneva, L. Nogués, Susumu Inoue, I. Puljak, M. V. Fonseca, Abelardo Moralejo, Nicola Giglietto, J. van Scherpenberg, Juan Cortina, Ferdinando Giordano, Kevin Schmidt, E. Moretti, D. Miceli, U. Barres de Almeida, Victoria Moreno, Valerio Vagelli, B. Banerjee, Shunsuke Sakurai, A. Babić, F. Di Pierro, D. Hadasch, M. Ribó, Oscar Blanch, T. Schweizer, Serena Loporchio, Marina Manganaro, A. De Angelis, A. Chilingaryan, Dominik Baack, M. Strzys, S. Cikota, Daniel Kerszberg, P. G. Prada Moroni, Chiara Righi, V. D'Elia, Wolfgang Rhode, G. Ceribella, M. López, Konstancja Satalecka, D. Mazin, Michele Doro, C. Arcaro, G. Busetto, Ciro Bigongiari, D. Zarić, Matteo Cerruti, R. López-Coto, Tomohiro Inada, J. Herrera, Léa Jouvin, F. Leone, Julian Sitarek, G. Ferrara, D. Dorner, Louis Antonelli, E. Colombo, D. Morcuende, N. Torres-Albà, M. Garczarczyk, I. Vovk, Dorota Sobczyńska, Victor A. Acciari, Y. Chai, Moritz Hütten, D. Strom, J. Rico, R. Paoletti, J. Besenrieder, David H. Green, T. Surić, M. Gaug, L. Di Venere, G. Bonnoli, D. Elsaesser, D. Ninci, Jose Miguel Miranda, E. Do Souto Espiñeira, Tomislav Terzić, S. M. Colak, Juan Abel Barrio, Narek Sahakyan, A. López-Oramas, Yusuke Suda, Carlo Vigorito, L. Saha, J. M. Paredes, Francesco Tombesi, Seiya Nozaki, Davide Depaoli, L. Foffano, M. Mariotti, Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), MAGIC, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Engels, A. A., Asano, K., Baack, D., Babic, A., Banerjee, B., De Almeida, U. B., Barrio, J. A., Gonzalez, J. B., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bosnjak, Z., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingaryan, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Elia, V., Vela, P. D., Dazzi, F., Angelis, A. D., Lotto, B. D., Delfino, M., Delgado, J., Depaoli, D., Pierro, F. D., Venere, L. D., Souto Espieira, E. D., Prester, D. D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Ramazani, V. F., Fattorini, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Lopez, R. J. G., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Godinovic, N., Green, D., Guberman, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Hutten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kerszberg, D., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lopez-Coto, R., Lopez-Oramas, A., Loporchio, S., De Oliveira Fraga, B. M., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Mazin, D., Micanovic, S., Miceli, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Nozaki, S., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Peil, P., Peresano, M., Persic, M., Moroni, P. G. P., Prandini, E., Puljak, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Schmidt, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Somero, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suric, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Torres-Alb, N., Tosti, L., Vagelli, V., Scherpenberg, J. V., Vanzo, G., Acosta, M. V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Zaric, D., Arcaro, C., Carosi, A., D'Ammando, F., Tombesi, F., Lohfink, A., 30588766 - Arcaro, Cornelia, Laboratoire d'Annecy de Physique des Particules (LAPP), German Research Foundation, Istituto Nazionale di Fisica Nucleare, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Department of Atomic Energy (India), Japan Society for the Promotion of Science, Ministry of Education, Culture, Sports, Science and Technology (Japan), Academy of Finland, Croatian Science Foundation, University of Rijeka, Polish National Agency for Academic Exchange, and European Commission
Subjects: Non-thermal radiation sources, VHE [gamma ray], Non-thermal radiation source, Astrophysics, 01 natural sciences, Relativistic jet, MAGIC (telescope), 010303 astronomy & astrophysics, model: leptonic, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, astro-ph.HE, education.field_of_study, Gamma ray, gamma ray: emission, quality, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies, BL Lacertae objects, Física nuclear, Catalog, Astrophysics and Astronomy, astro-ph.GA, Astrophysics::High Energy Astrophysical Phenomena, Population, energy spectrum, FOS: Physical sciences, Proton Synchrotron, magnetization, BL Lacertae object, leptonic [model], blazar, X-ray, Settore FIS/05 - Astronomia e Astrofisica, emission [gamma ray], 0103 physical sciences, synchrotron, education, Blazar, Active galactic nuclei, Gamma-ray sources, X-ray active galactic nuclei, 010308 nuclear & particles physics, Spectral density, Astronomy and Astrophysics, Catalogues, proton synchrotron, MAGIC, Synchrotron emission, Blazars, Relativistic jets, Catalogs, Automatic Keywords, gamma ray: VHE, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), ddc:520, spectral, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: Extreme high-frequency-peaked BL Lac objects (EHBLs) are blazars that exhibit extremely energetic synchrotron emission. They also feature nonthermal gamma-ray emission whose peak lies in the very high-energy (VHE, E > 100 GeV) range, and in some sources exceeds 1 TeV: this is the case for hard-TeV EHBLs such as 1ES 0229+200. With the aim of increasing the EHBL population, 10 targets were observed with the MAGIC telescopes from 2010 to 2017, for a total of 265 hr of good-quality data. The data were complemented by coordinated Swift observations. The X-ray data analysis confirms that all but two sources are EHBLs. The sources show only a modest variability and a harder-when-brighter behavior, typical for this class of objects. At VHE gamma-rays, three new sources were detected and a hint of a signal was found for another new source. In each case, the intrinsic spectrum is compatible with the hypothesis of a hard-TeV nature of these EHBLs. The broadband spectral energy distributions (SEDs) of all sources are built and modeled in the framework of a single-zone, purely leptonic model. The VHE gamma-ray-detected sources were also interpreted with a spine-layer model and a proton synchrotron model. The three models provide a good description of the SEDs. However, the resulting parameters differ substantially in the three scenarios, in particular the magnetization parameter. This work presents the first mini catalog of VHE gamma-ray and multiwavelength observations of EHBLs., We would like to thank the Instituto de Astrofísica de Canarias for the excellent working conditions at the Observatorio del Roque de los Muchachos in La Palma. The financial support of the German BMBF and MPG, the Italian INFN and INAF, the Swiss National Fund SNF, the ERDF under the Spanish MINECO (FPA2015-69818-P, FPA2012-36668, FPA 2015-68378-P, FPA2017-82729-C6-2-R, FPA2015-69210-C6- 4-R, FPA2015-69210-C6-6-R, AYA2015-71042-P, AYA2016- 76012-C3-1-P, ESP2015-71662-C2-2-P, FPA2017-90566-RE DC), the Indian Department of Atomic Energy, the Japanese JSPS and MEXT, the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-153/28.08.2018, and the Academy of Finland grant nr. 320045 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2016-0588 and SEV-2015-0548, and Unidad de Excelencia “María de Maeztu” MDM-2014-0369, by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3, the Polish National Research Centre grant UMO-2016/22/M/ST9/00382, and by the Brazilian MCTIC, CNPq and FAPERJ. E.P. has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska–Curie grant agreement No. 664931. M.C. has received financial support through the Postdoctoral Junior Leader Fellowship Programme from la Caixa Banking Foundation, grant No. LCF/BQ/LI18/11630012.
Published: 2020

35. MAGIC very large zenith angle observations of the Crab Nebula up to 100 TeV

Author: David Paneque, A. Biland, T. Schweizer, D. Ninci, Elina Lindfors, J. Besenrieder, D. Guberman, Masahiro Teshima, Chiara Righi, Daniel Mazin, A. De Angelis, J. Becerra González, A. Berti, S. Ansoldi, N. Godinović, S. Fukami, B. Machado de Oliveira Fraga, L. Bellizzi, Giacomo Bonnoli, D. Dominis Prester, K. Mannheim, N. Torres-Albà, J. Palacio, J. van Scherpenberg, P. Da Vela, A. Babić, D. Elsaesser, M. Ribó, D. Morcuende, P. Peñil, F. Leone, I. Šnidarić, A. Rugliancich, Marina Manganaro, V. Moreno, Dario Hrupec, Antonio Stamerra, P. G. Prada Moroni, G. Ceribella, Massimo Persic, Stefano Covino, Konstancja Satalecka, V. Fallah Ramazani, L. Nogués, P. Majumdar, Jose Carlos Herrera, Michele Doro, M. A. Lopez, G. Maneva, Elisa Prandini, D. Miceli, D. Fidalgo, Julian Sitarek, M. Mariotti, S. Cikota, M. I. Martínez, Razmik Mirzoyan, L. Saha, A. Chilingaryan, W. Rhode, G. Vanzo, M. Strzys, J. M. Paredes, Kyoshi Nishijima, U. Barres de Almeida, U. Colin, David A. Green, D. Hadasch, E. Do Souto Espiñeira, Tomislav Terzić, Ciro Bigongiari, D. Dorner, L. A. Antonelli, Petar Temnikov, M. Mallamaci, M. Minev, W. Bhattacharyya, Christian Fruck, S. Lombardi, D. Zarić, Jordi Delgado, John Hoang, Elisa Bernardini, G. Busetto, Y. Suda, Jose Luis Contreras, Dorota Sobczyńska, C. Maggio, Juan Cortina, R. López-Coto, Saša Mićanović, T. Surić, D. Lelas, Fabrizio Tavecchio, Y. Chai, Seiya Nozaki, S. Gasparyan, A. Lamastra, Eduardo Colombo, Ll. Font, S. M. Colak, D. Strom, J. Kushida, V. Vagelli, M. V. Fonseca, Auni Somero, M. Peresano, Kevin Schmidt, A. Arbet Engels, F. Di Pierro, M. Palatiello, Vitaly Neustroev, Luca Tosti, Juan Abel Barrio, M. Takahashi, I. Puljak, Narek Sahakyan, Carlo Vigorito, Laura Maraschi, Francesco Dazzi, Riccardo Paoletti, Markus Gaug, M. Vazquez Acosta, Nicola Giglietto, Valerio D'Elia, M. Delfino, A. López-Oramas, P. Munar-Adrover, G. Ferrara, Susumu Inoue, Abelardo Moralejo, E. Moretti, D. Depaoli, C. Nigro, V. A. Acciari, M. Makariev, Dominik Baack, R. J. García López, Luca Foffano, Francesco Giordano, Kari Nilsson, J. Rico, H. Kubo, Daniel Kerszberg, M. Will, Ž. Bošnjak, L. Jouvin, S. Loporchio, Simona Paiano, K. Noda, Jose Miguel Miranda, Edgar Molina, T. Saito, L. Di Venere, M. Hütten, B. Banerjee, Shunsuke Sakurai, Vincenzo Vitale, Ievgen Vovk, A. Hahn, Y. Iwamura, Markus Garczarczyk, Kazuma Ishio, B. De Lotto, W. Bednarek, Francesco Longo, Oscar Blanch, A. Fattorini, Roberto Carosi, Tomohiro Inada, A. Donini, Federal Ministry of Education and Research (Germany), Istituto Nazionale di Fisica Nucleare, Istituto Nazionale di Astrofisica, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Department of Atomic Energy (India), Ministry of Education, Youth and Science (Bulgaria), Academy of Finland, Universidad de Barcelona, Croatian Science Foundation, University of Rijeka, Ministério da Ciência, Tecnologia e Inovação (Brasil), Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Baack, D., Babic, A., Banerjee, B., Barres De Almeida, U., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bosnjak, Z., Busetto, G., Carosi, R., Ceribella, G., Chai, Y., Chilingaryan, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espineira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Garcia Lopez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Godinovic, N., Green, D., Guberman, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Hutten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kerszberg, D., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lopez-Coto, R., Lopez-Oramas, A., Loporchio, S., Machado De Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Mazin, D., Micanovic, S., Miceli, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Nozaki, S., Paiano, S., Palacio, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Penil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Schmidt, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Somero, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suric, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Torres-Alba, N., Tosti, L., Vagelli, V., Van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., and Zaric, D.
Subjects: Gamma rays: general, ISM: supernova remnants, Methods: observational, Astronomy, gamma rays general, methods observational, ISM supernova remnants, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics, model [emission], generalI [Gamma rays], Astrophysics, 01 natural sciences, Raigs gamma, optical, MAGIC (telescope), 010303 astronomy & astrophysics, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Supernoves, supernova remnants [ISM], Astrophysics::Instrumentation and Methods for Astrophysics, imaging, Supernovae, Gamma rays: generalI, high [energy], Spectral energy distribution, Física nuclear, Astrophysics::High Energy Astrophysical Phenomena, general [Gamma rays], FOS: Physical sciences, SM: supernova remnants, monitoring [atmosphere], emission [gamma ray], 0103 physical sciences, Calibration, observational [Methods], 14. Life underwater, 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Cherenkov radiation, Zenith, Computer Science::Information Retrieval, Gamma rays, Astronomy and Astrophysics, calibration, supernova remnants [SM], MAGIC, Cherenkov counter, Crab Nebula, Space and Planetary Science, ddc:520, spectral, supernova remnant [ISM], Energy (signal processing), Fermi Gamma-ray Space Telescope
Abstract: Aims. We measure the Crab Nebula γ-ray spectral energy distribution in the ~100 TeV energy domain and test the validity of existing leptonic emission models at these high energies. Methods. We used the novel very large zenith angle observations with the MAGIC telescope system to increase the collection area above 10 TeV. We also developed an auxiliary procedure of monitoring atmospheric transmission in order to assure proper calibration of the accumulated data. This employs recording optical images of the stellar field next to the source position, which provides a better than 10% accuracy for the transmission measurements. Results. We demonstrate that MAGIC very large zenith angle observations yield a collection area larger than a square kilometer. In only ~ 56 h of observations, we detect the γ-ray emission from the Crab Nebula up to 100 TeV, thus providing the highest energy measurement of this source to date with Imaging Atmospheric Cherenkov Telescopes. Comparing accumulated and archival MAGIC and Fermi/LAT data with some of the existing emission models, we find that none of them provides an accurate description of the 1 GeV to 100 TeV γ-ray signal., The financial support of the German BMBF and MPG, the Italian INFN and INAF, the Swiss National Fund SNF, the ERDF under the Spanish MINECO (FPA2015-69818-P, FPA2012-36668, FPA2015-68378-P, FPA2015-69210-C6-2-R, FPA2015-69210-C6-4-R, FPA2015-69210-C6-6-R, AYA2015-71042-P, AYA2016-76012-C3-1-P, ESP2015-71662-C2-2-P, FPA2017-90566-REDC), the Indian Department of Atomic Energy, the Japanese JSPS and MEXT, the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-153/28.08.2018 and the Academy of Finland grant nr. 320045 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2016-0588 and SEV-2015-0548, and Unidad de Excelencia “María de Maeztu” MDM-2014-0369, by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3, the Polish National Research Centre grant UMO-2016/22/M/ST9/00382 and by the Brazilian MCTIC, CNPq and FAPERJ. This research has made use of the CTA instrument response functions provided by the CTA Consortium and Observatory, see http://www.cta-observatory.org/science/cta-performance/ (version prod3b-v1) for more details.
Published: 2020

36. Off-label use of vincristine for intralesional treatment of isolated papules in Kaposi's sarcoma: Dermatologic experience with 10 patients

Author: T, Peduto, G, Fabbrocini, M, Delfino, P, Nappa, M, Guarino, F, Cillo, Peduto, T., Fabbrocini, G., Delfino, M., Nappa, P., Guarino, M., and Cillo, F.
Subjects: Aged, 80 and over, Male, Skin Neoplasms, Off-Label Use, Injections, Intralesional, Middle Aged, Antineoplastic Agents, Phytogenic, Mouth Neoplasm, Vincristine, Humans, Mouth Neoplasms, Female, Skin Neoplasm, Sarcoma, Kaposi, Aged, Human
Published: 2020

37. A metabolic control analysis approach to introduce the study of systems in biochemistry: the glycolytic pathway in the red blood cell

Author: María V. Espelt, Pablo J. Schwarzbaum, Mariela S. Ferreira-Gomes, José M. Delfino, Carla Romina Angelani, Damiana María Salvatierra Fréchou, Nicolás A. Saffioti, Gabriela E. Gómez, Karen Magalí Cruz, Irene C. Mangialavori, Pablo Carabias, Marilina de Sautu, María Florencia Pignataro, Javier Santos, and Malena Manzi
Subjects: 0301 basic medicine, chemistry.chemical_classification, Metabolite, Context (language use), Metabolism, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Glycolysis Inhibition, 030104 developmental biology, 0302 clinical medicine, Enzyme, chemistry, 030220 oncology & carcinogenesis, Metabolic control analysis, Glycolysis, Molecular Biology, Flux (metabolism)
Abstract: Metabolic control analysis (MCA) is a promising approach in biochemistry aimed at understanding processes in a quantitative fashion. Here the contribution of enzymes and transporters to the control of a given pathway flux and metabolite concentrations is determined and expressed quantitatively by means of numerical coefficients. Metabolic flux can be influenced by a wide variety of modulators acting on one or more metabolic steps along the pathway. We describe a laboratory exercise to study metabolic regulation of human erythrocytes (RBCs). Within the framework of MCA, students use these cells to determine the sensitivity of the glycolytic flux to two inhibitors (iodoacetic acid: IA, and iodoacetamide: IAA) known to act on the enzyme glyceraldehyde-3-phosphate-dehydrogenase. Glycolytic flux was estimated by determining the concentration of extracellular lactate, the end product of RBC glycolysis. A low-cost colorimetric assay was implemented, that takes advantage of the straightforward quantification of the absorbance signal from the photographic image of the multi-well plate taken with a standard digital camera. Students estimate flux response coefficients for each inhibitor by fitting an empirical function to the experimental data, followed by analytical derivation of this function. IA and IAA exhibit qualitatively different patterns, which are thoroughly analyzed in terms of the physicochemical properties influencing their action on the target enzyme. IA causes highest glycolytic flux inhibition at lower concentration than IAA. This work illustrates the feasibility of using the MCA approach to study key variables of a simple metabolic system, in the context of an upper level biochemistry course. © 2018 International Union of Biochemistry and Molecular Biology, 46(5):502-515, 2018.
Published: 2018

38. Prevalence of hepatitis D virus in blood donors with different hepatitis B virus markers of infection

Author: Verónica L. Mathet, Cecilia M. Delfino, Gabriela Pataccini, Williams René Pedrozo, and Mirna Biglione
Subjects: Hepatitis B virus, Hepatitis B Surface Antigens, Hepatology, business.industry, Gastroenterology, Blood Donors, Hepatitis B, medicine.disease_cause, Virology, Prevalence, medicine, Humans, Hepatitis D virus, Hepatitis B Antibodies, Hepatitis Delta Virus, business
Published: 2021

39. Kinetic and thermodynamic studies of the interaction between activating and inhibitory Ly49 natural killer receptors and MHC class I molecules

Author: Emilio L. Malchiodi, Maria Belén Sarratea, Pablo Nicolas Romasanta, Roy A. Mariuzza, Marisa M. Fernández, Lucrecia María Curto, María Julieta Fernández Lynch, José M. Delfino, Sofia Noli Truant, and María Belén Antonoglou
Subjects: 0301 basic medicine, Circular dichroism, Stereochemistry, Otras Ciencias Biológicas, Ly49 receptors, NK cells, Major histocompatibility complex, Biochemistry, Ciencias Biológicas, Mice, 03 medical and health sciences, MHC class I, Animals, Surface plasmon resonance, Binding site, Histocompatibility Antigen H-2D, Receptor, Molecular Biology, Mice, Inbred BALB C, Innate immune system, biology, Cell Biology, Surface Plasmon Resonance, Kinetics, 030104 developmental biology, positive co-operativity, Multiprotein Complexes, biology.protein, Biophysics, Thermodynamics, CIENCIAS NATURALES Y EXACTAS, NK Cell Lectin-Like Receptor Subfamily A, Fluorescence anisotropy
Abstract: Natural killer (NK) cells are lymphocytes of the innate immune system that eliminate virally infected or malignantly transformed cells. NK cell function is regulated by diverse surface receptors that are both activating and inhibitory. Among them, the homodimeric Ly49 receptors control NK cell cytotoxicity by sensing major histocompatibility complex class I molecules (MHC-I) on target cells. Although crystal structures have been reported for Ly49/MHC-I complexes, the underlying binding mechanism has not been elucidated. Accordingly, we carried out thermodynamic and kinetic experiments on the interaction of four NK Ly49 receptors (Ly49G, Ly49H, Ly49I and Ly49P) with two MHC-I ligands (H-2Dd and H-2Dk). These Ly49s embrace the structural and functional diversity of the highly polymorphic Ly49 family. Combining surface plasmon resonance, fluorescence anisotropy and far-UV circular dichroism (CD), we determined that the best model to describe both inhibitory and activating Ly49/MHC-I interactions is one in which the two MHC-I binding sites of the Ly49 homodimer present similar binding constants for the two sites (∼106 M–1) with a slightly positive co-operativity in some cases, and without far-UV CD observable conformational changes. Furthermore, Ly49/MHC-I interactions are diffusion-controlled and enthalpy-driven. These features stand in marked contrast with the activation-controlled and entropy-driven interaction of Ly49s with the viral immunoevasin m157, which is characterized by strong positive co-operativity and conformational selection. These differences are explained by the distinct structures of Ly49/MHC-I and Ly49/m157 complexes. Moreover, they reflect the opposing roles of NK cells to rapidly scan for virally infected cells and of viruses to escape detection using immunoevasins such as m157. Fil: Romasanta, Pablo Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina Fil: Curto, Lucrecia María. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina Fil: Sarratea, Maria Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina Fil: Noli Truant, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina Fil: Antonoglou, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina Fil: Fernández Lynch, María Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina Fil: Delfino, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina Fil: Mariuzza, Roy A.. University of Maryland; Estados Unidos Fil: Fernández, Marisa Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina Fil: Malchiodi, Emilio Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Published: 2016

40. Global Implications of Local Unfolding Phenomena, Probed by Cysteine Reactivity in Human Frataxin

Author: Santiago Enrique Faraj, Martín Ezequiel Noguera, Javier Santos, and José M. Delfino
Subjects: 0301 basic medicine, Multidisciplinary, biology, Philosophy, lcsh:R, lcsh:Medicine, Article, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Frataxin, biology.protein, lcsh:Q, Reactivity (chemistry), lcsh:Science, Author Correction, Humanities, 030217 neurology & neurosurgery, Cysteine
Abstract: Local events that affect specific regions of proteins are of utmost relevance for stability and function. The aim of this study is to quantitatively assess the importance of locally-focused dynamics by means of a simple chemical modification procedure. Taking human Frataxin as a working model, we investigated local fluctuations of the C-terminal region (the last 16 residues of the protein) by means of three L → C replacement mutants: L98C, L200C and L203C. The conformation and thermodynamic stability of each variant was assessed. All the variants exhibited native features and high stabilities: 9.1 (wild type), 8.1 (L198C), 7.0 (L200C) and 10.0 kcal mol−1 (L203C). In addition, kinetic rates of Cys chemical modification by DTNB and DTDPy were measured, conformational dynamics data were extracted and free energy for the local unfolding of the C-terminal region was estimated. The analysis of these results indicates that the conformation of the C-terminal region fluctuates with partial independence from global unfolding events. Additionally, numerical fittings of the kinetic model of the process suggest that the local transition occurs in the seconds to minutes timescale. In fact, standard free energy differences for local unfolding were found to be significantly lower than those of the global unfolding reaction, showing that chemical modification results may not be explained in terms of the global unfolding reaction alone. These results provide unequivocal experimental evidence of local phenomena with global effects and contribute to understanding how global and local stability are linked to protein dynamics.
Published: 2019

41. An inhibitory mechanism of action of coiled‐coil peptides against type three secretion system from enteropathogenic<scp>Escherichia coli</scp>

Author: Daniel Enriz, Silvana L. Giudicessi, Wanderson M. Silva, José M. Delfino, Gabriela E. Gómez, Mariano Larzabal, Silvia A. Camperi, Lucrecia María Curto, Héctor A. Baldoni, Angel Cataldi, and Fernando D. Suvire
Subjects: TYPE THREE SECRETION SYSTEM, Models, Molecular, Virulence, Microbial Sensitivity Tests, 010402 general chemistry, 01 natural sciences, Biochemistry, COILED-COIL DOMAINS, Type three secretion system, Ciencias Biológicas, Enteropathogenic Escherichia coli, Biología Celular, Microbiología, Structural Biology, Drug Discovery, Type III Secretion Systems, medicine, Humans, Secretion, MOLECULAR MODELING, Molecular Biology, Pharmacology, Coiled coil, chemistry.chemical_classification, biology, 010405 organic chemistry, Chemistry, Circular Dichroism, Organic Chemistry, ENTEROPATHOGENIC ESCHERICHIA COLI, PEPTIDES, General Medicine, biology.organism_classification, medicine.disease, Hemolysis, Anti-Bacterial Agents, 0104 chemical sciences, Amino acid, Thermodynamics, bacteria, Molecular Medicine, Peptides, CIENCIAS NATURALES Y EXACTAS, Bacteria
Abstract: Human pathogenic gram-negative bacteria, such as enteropathogenic Escherichia coli (EPEC), rely on type III secretion systems (T3SS) to translocate virulence factors directly into host cells. The coiled-coil domains present in the structural proteins of T3SS are conformed by amphipathic alpha-helical structures that play an important role in the protein-protein interaction and are essential for the assembly of the translocation complex. To investigate the inhibitory capacity of these domains on the T3SS of EPEC, we synthesized peptides between 7 and 34 amino acids based on the coiled-coil domains of proteins that make up this secretion system. This analysis was performed through in vitro hemolysis assays by assessing the reduction of T3SS-dependent red blood cell lysis in the presence of the synthesized peptides. After confirming its inhibitory capacity, we performed molecular modeling assays using combined techniques, docking-molecular dynamic simulations, and quantum-mechanic calculations of the various peptide-protein complexes, to improve the affinity of the peptides to the target proteins selected from T3SS. These techniques allowed us to demonstrate that the peptides with greater inhibitory activity, directed against the coiled-coil domain of the C-terminal region of EspA, present favorable hydrophobic and hydrogen bond molecular interactions. Particularly, the hydrogen bond component is responsible for the stabilization of the peptide-protein complex. This study demonstrates that compounds targeting T3SS from pathogenic bacteria can indeed inhibit bacterial infection by presenting a higher specificity than broad-spectrum antibiotics. In turn, these peptides could be taken as initial structures to design and synthesize new compounds that mimic their inhibitory pharmacophoric pattern. Fil: Larzabal, Mariano. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación En Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Baldoni, Hector Armando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi". Universidad Nacional de San Luis. Facultad de Ciencias Físico, Matemáticas y Naturales. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi"; Argentina Fil: Suvire, Fernando Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Curto, Lucrecia María. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina Fil: Gomez, Gabriela Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina Fil: Marques Da Silva, Wanderson. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación En Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Giudicessi, Silvana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina Fil: Camperi, Silvia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina Fil: Delfino, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina Fil: Cataldi, Angel Adrian. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación En Ciencias Veterinarias y Agronómicas. Instituto de Agrobiotecnología y Biología Molecular. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Agrobiotecnología y Biología Molecular; Argentina Fil: Enriz, Ricardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Published: 2019

42. The Physics of the Accelerating Universe Camera

Author: José M. Illa, Enrique Fernández, J. Carretero, Pau Tallada, M. Delfino, Carlos Díaz, I. Sevilla-Noarbe, Martin Crocce, Juan de Vicente, Francisco J. Castander, Javier Castilla, Juan Garcia-Bellido, A. Alarcon, Martin Eriksen, Luis Lopez, C. Neissner, Jelena Aleksić, S. Serrano, Cristóbal Pío, Pablo Fosalba, Laia Cardiel-Sas, Ramon Miquel, Nadia Tonello, Laura Cabayol, Cristobal Padilla, Ricard Casas, O. Ballester, Ferran Grañena, Pol Martí, Enrique Gaztanaga, J. Gaweda, E. J. Sanchez, and Jorge Jiménez
Subjects: Physics, 010504 meteorology & atmospheric sciences, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, FOS: Physical sciences, Astronomy and Astrophysics, Field of view, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Galaxy, Redshift, Photometry (optics), Cardinal point, Space and Planetary Science, 0103 physical sciences, William Herschel Telescope, Galaxy formation and evolution, Spectral energy distribution, Astrophysics - Instrumentation and Methods for Astrophysics, 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Astrophysics::Galaxy Astrophysics, 0105 earth and related environmental sciences
Abstract: The PAU (Physics of the Accelerating Universe) Survey goal is to obtain photometric redshifts (photo-z) and Spectral Energy Distribution (SED) of astronomical objects with a resolution roughly one order of magnitude better than current broad band photometric surveys. To accomplish this, a new large field of view camera (PAUCam) has been designed, built, commissioned and is now operated at the William Herschel Telescope (WHT). With the current WHT Prime Focus corrector, the camera covers ~1-degree diameter Field of View (FoV), of which, only the inner ~40 arcmin diameter are unvignetted. The focal plane consists of a mosaic of 18 2k$x4k Hamamatsu fully depleted CCDs, with high quantum efficiency up to 1 micrometers in wavelength. To maximize the detector coverage within the FoV, filters are placed in front of the CCDs inside the camera cryostat (made out of carbon fiber) using a challenging movable tray system. The camera uses a set of 40 narrow band filters ranging from ~4500 to ~8500 Angstroms complemented with six standard broad-band filters, ugrizY. The PAU Survey aims to cover roughly 100 square degrees over fields with existing deep photometry and galaxy shapes to obtain accurate photometric redshifts for galaxies down to i_AB~22.5, detecting also galaxies down to i_AB~24 with less precision in redshift. With this data set we will be able to measure intrinsic alignments, galaxy clustering and perform galaxy evolution studies in a new range of densities and redshifts. Here, we describe the PAU camera, its first commissioning results and performance., 34 pages, 55 figures
Published: 2019

43. Deep observations of the globular cluster M15 with the MAGIC telescopes

Author: B. Machado de Oliveira Fraga, A. Lamastra, Jordi Delgado, P. Giammaria, Razmik Mirzoyan, D. Baack, D. Galindo, Massimo Persic, John Hoang, E. Moretti, J. Palacio, Pablo Peñil, Chiara Righi, A. Hahn, R. J. García López, Kari Nilsson, P. Majumdar, J. M. Paredes, Antonio Stamerra, J. Becerra González, Dorota Sobczyńska, Francesco Longo, Satoshi Masuda, D. Dominis Prester, Adrian Biland, S. Gasparyan, Y. Iwamura, M. Strzys, J. Kushida, S. M. Colak, Abelardo Moralejo, Jose Luis Contreras, Juan Cortina, A. Fernández-Barral, N. Godinović, Takashi Saito, Pierre Colin, Tihomir Surić, Francesco Leone, W. Rhode, M. V. Fonseca, I. Puljak, P G Prada Moroni, N. Sahakyan, W. Bhattacharyya, V. Fallah Ramazani, J. Rico, P. Munar-Adrover, Oscar Blanch, A. Somero, Saverio Lombardi, Louis Antonelli, U. Barres de Almeida, A. Niedzwiecki, D. Fidalgo, M. Will, David H. Green, Edgar Molina, V. D'Elia, E. Colombo, S. Gallozzi, A. De Angelis, G. Vanzo, Petar Temnikov, Koji Noda, Ana Babić, Stefan Cikota, A. Fattorini, D. Ninci, Shimpei Tsujimoto, M. I. Martínez, M. Vazquez Acosta, Stefano Ansoldi, Elisa Bernardini, Masahiro Teshima, M. Peresano, Giovanni Busetto, M. Mallamaci, F. Di Pierro, Lab Saha, B. De Lotto, D. Dorner, Markus Gaug, M. López, Elisa Prandini, A. Arbet Engels, D. Hadasch, Sabrina Einecke, Victoria Moreno, D. Kuveždić, Julian Sitarek, Rodolfo Carosi, D. Lelas, Vitaly Neustroev, Francesco Dazzi, Darko Zarić, Jürgen Besenrieder, K. Mannheim, Juan Abel Barrio, D. Elsaesser, I. Vovk, M. Makariev, Ciro Bigongiari, Aaron Dominguez, M. Nöthe, S. Paiano, B. Banerjee, K. Ishio, C. Nigro, G. Ceribella, G. Pedaletti, W. Bednarek, C. Maggio, G. Maneva, E. Do Souto Espiñera, Fabrizio Tavecchio, Ll. Font, Tomislav Terzić, Susumu Inoue, M. Nievas Rosillo, Dario Hrupec, R. Paoletti, A. López-Oramas, L. Foffano, L. Maraschi, M. Delfino, Marc Ribó, Jose Carlos Herrera, Elina Lindfors, Daniel Mazin, A. Berti, J. R. Garcia, Stefano Covino, M. Minev, Hidetoshi Kubo, G. Bonnoli, T. Schweizer, L. Nogués, M. Mariotti, M. Garczarczyk, V. A. Acciari, J. van Scherpenberg, K. Nishijima, P. Da Vela, Iva Šnidarić, A. Rugliancich, Marina Manganaro, G. Ferrara, D. Paneque, Konstancja Satalecka, Michele Doro, C. Fruck, D. Guberman, N. Torres-Albà, Jose Miguel Miranda, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Baack, D., Babic, A., Banerjee, B., Barres De Almeida, U., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Busetto, G., Carosi, R., Ceribella, G., Cikota, S., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Di Pierro, F., Do Souto Espinera, E., Dominguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fernandez-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., Gallozzi, S., Garcia Lopez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giammaria, P., Godinovic, N., Green, D., Guberman, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Inoue, S., Ishio, K., Iwamura, Y., Kubo, H., Kushida, J., Kuvezdic, D., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lopez-Oramas, A., Machado De Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Masuda, S., Mazin, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Nothe, M., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Penil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Somero, A., Stamerra, A., Strzys, M., Suric, T., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Torres-Alba, N., Tsujimoto, S., Van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Vovk, I., Will, M., and Zaric, D.
Subjects: Radiation mechanisms: non-thermal, Astrophysics::High Energy Astrophysical Phenomena, Population, general [Pulsars], Globular clusters: general, FOS: Physical sciences, astro-ph.HE, Astrophysics, 01 natural sciences, 7. Clean energy, stars [gamma-rays], Pulsar, Millisecond pulsar, 0103 physical sciences, Gamma-rays: stars, Globular clusters: individual: M15, Pulsars: general, Astronomy and Astrophysics, Space and Planetary Science, Astrophysics::Solar and Stellar Astrophysics, star [Gamma-rays], education, 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, education.field_of_study, individual: M15 [Globular clusters], non-thermal [Radiation mechanisms], 010308 nuclear & particles physics, Compton scattering, Stars, Crab Nebula, Globular cluster, ddc:520, High Energy Physics::Experiment, Electrónica, general [Globular clusters], radiation mechanisms: non-thermal, pulsars: general, globular clusters: general, globular clusters: individual: M15, gamma-rays: stars, Electricidad, Astrophysics - High Energy Astrophysical Phenomena, Lepton
Abstract: A population of globular clusters (GCs) has been recently established by the Fermi-LAT telescope as a new class of GeV $\gamma$-ray sources. Leptons accelerated to TeV energies, in the inner magnetospheres of MSPs or in their wind regions, should produce $\gamma$-rays through the inverse Compton scattering in the dense radiation field from the huge population of stars. We have conducted deep observations of the globular cluster M15 with the MAGIC telescopes and used 165 hrs in order to search for $\gamma$-ray emission. A strong upper limit on the TeV $\gamma$-ray flux $, Comment: 11 pages, 7 figures, accepted for publication in MNRAS
Published: 2019

44. Multinationality with variable geometry

Author: M. DELFINO and Delfino, M.
Published: 2019

45. Proposte di legge in tema di minimo salariale, orientamenti delle Alte Corti e rischi di disintermediazione

Author: M. DELFINO, L. ZOPPOLI, Delfino, M., and Zoppoli, L.
Published: 2019

46. Gli attori del procedimento negoziale: agenzia per la rappresentanza negoziale della pubblica amministrazione e comitati di settore

Author: M. DELFINO, BALDASSARRE, Antonio, L. Fiorillo, Delfino, M., and Baldassarre, Antonio
Published: 2019

47. La Corte costituzionale e il catuc nella prospettiva degli ordinamenti sovranazionali

Author: M. DELFINO and Delfino, M.
Published: 2019

48. Discovery of TeV γ-ray emission from the neighbourhood of the supernova remnant G24.7+0.6 by MAGIC

Author: R. J. García López, P G Prada Moroni, C. Arcaro, M. Vazquez Acosta, Masahiro Teshima, Elina Lindfors, Nikola Godinovic, Victoria Moreno, Daniel Mazin, Saverio Lombardi, A. Fernández-Barral, Chiara Righi, Pratik Majumdar, M. V. Fonseca, L. Nogués, Cosimo Nigro, M. Nievas Rosillo, Lluis Font, D. Dorner, A. Lamastra, M. Minev, R. Zanin, P. Temnikov, D. Elsaesser, J. Palacio, J. M. Paredes, Antonio Stamerra, Marcel Strzys, V. D'Elia, Martin Will, Stefano Covino, D. Zarić, Adrian Biland, D.F. Torres, Dario Hrupec, R. Paoletti, Wrijupan Bhattacharyya, B. Banerjee, A. Fattorini, Marc Ribó, S. Ansoldi, P. Giammaria, M. A. Lopez, Karl Mannheim, P. Bangale, Junko Kushida, J. Delgado, J. Rico, Kyoshi Nishijima, Tomoki Saito, Giovanni Ceribella, Satoshi Masuda, John Hoang, U. Barres de Almeida, Arka Chatterjee, Tarek M. Hassan, Hidetoshi Kubo, S. Paiano, Aaron Dominguez, F. Di Pierro, D. Kuveždić, Jürgen Besenrieder, Alexander Hahn, D. Hadasch, A. Rugliancich, Marina Manganaro, Fabrizio Tavecchio, M. I. Martínez, D. Fidalgo, Juan Abel Barrio, J. Becerra González, J. E. Ward, Damir Lelas, Francesco Longo, I. Snidaric, Sidika Merve Colak, G. Ferrara, E. Colombo, Sabrina Einecke, M. Delfino, Lab Saha, D. Dominis Prester, Alessio Berti, Ievgen Vovk, Louis Antonelli, A. Arbet Engels, S. Gallozzi, Gaia Vanzo, P. Cumani, Konstancja Satalecka, A. De Angelis, D. Ninci, Michele Doro, Dorota Sobczyńska, Martin Makariev, Ana Babić, Oscar Blanch, R. Mirzoyan, Vitaly Neustroev, W. Bednarek, T. Schweizer, Jose Luis Contreras, Christian Fruck, Julian Sitarek, Juan Cortina, J. Herrera, V. Fallah Ramazani, G. Bonnoli, David Paneque, M. Mariotti, Koji Noda, A. López-Oramas, Ivica Puljak, D. Guberman, Elisa Bernardini, G. Pedaletti, G. Maneva, D. Baack, M. Persic, P. Colin, V. A. Acciari, P. Da Vela, L. Foffano, L. Maraschi, Tomislav Terzić, Kari Nilsson, Yuki Iwamura, Susumu Inoue, J. R. Garcia, Camilla Maggio, Kazuma Ishio, E. de Oña Wilhelmi, A. Niedzwiecki, Elisa Prandini, Rodolfo Carosi, M. Peresano, N. Torres-Albà, Jose Miguel Miranda, D. Galindo, Francesco Leone, T. Surić, Shimpei Tsujimoto, Abelardo Moralejo, E. Moretti, Edgar Molina, B. De Lotto, Markus Gaug, Ciro Bigongiari, M. Garczarczyk, W. Rhode, Francesco Dazzi, A. Somero, Pablo Peñil, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Arcaro, C., Baack, D., Babić, A., Banerjee, B., Bangale, P., De Almeida, U Barre, Barrio, J. A., Becerra González, J., Bednarek, W., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Carosi, R., Ceribella, G., Chatterjee, A., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Cumani, P., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Di Pierro, F., Domínguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fernández-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., Gallozzi, S., García López, R. J., Garczarczyk, M., Gaug, M., Giammaria, P., Godinović, N., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Herrera, J., Hoang, J., Hrupec, D., Inoue, S., Ishio, K., Iwamura, Y., Kubo, H., Kushida, J., Kuveždić, D., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., López, M., López-Oramas, A., Maggio, C., Majumdar, P., Makariev, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martínez, M., Masuda, S., Mazin, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Moreno, V., Moretti, E., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogués, L., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Peñil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Šnidarić, I., Sobczynska, D., Somero, A., Stamerra, A., Strzys, M., Surić, T., Tavecchio, F., Temnikov, P., Terzić, T., Teshima, M., Torres-Albà, N., Tsujimoto, S., Vanzo, G., Vazquez Acosta, M., Vovk, I., Ward, J. E., Will, M., Zarić, D., De Oña Wilhelmi, E., Torres, D. F., and Zanin, R.
Subjects: Astrophysics::High Energy Astrophysical Phenomena, cloud [ISM], ISM:supernova remnants, acceleration of particles, ISM: clouds, cosmic rays, ISM: supernova remnants, gamma-rays: general, astro-ph.HE, Cosmic ray, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, Astronomy and Astrophysics, Space and Planetary Science, 01 natural sciences, Spectral line, 0103 physical sciences, Supernova remnant, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, acceleration of particle, cosmic ray, Cherenkov radiation, Physics, Spectral index, 010308 nuclear & particles physics, supernova remnants [ISM], Spectral density, Astronomy and Astrophysic, acceleration of particles, cosmic rays, ISM:supernova remnants, ISM: clouds, gamma-rays: general, Acceleration of particles, cosmic rays, gamma-rays: general, ISM: clouds, ISM: supernova remnants, Supernova, 13. Climate action, ddc:520, supernova remnant [ISM], Física nuclear, Astrophysics - High Energy Astrophysical Phenomena, clouds [ISM], general [gamma-rays], Radio wave
Abstract: SNR G24.7+0.6 is a 9.5 kyrs radio and $\gamma$-ray supernova remnant evolving in a dense medium. In the GeV regime, SNR G24.7+0.6 (3FHL\,J1834.1--0706e/FGES\,J1834.1--0706) shows a hard spectral index ($\Gamma$$\sim$2) up to $200$\,GeV, which makes it a good candidate to be observed with Cherenkov telescopes such as MAGIC. We observed the field of view of \snr\ with the MAGIC telescopes for a total of 31 hours. We detect very high energy $\gamma$-ray emission from an extended source located 0.34\degr\ away from the center of the radio SNR. The new source, named \mgc\ is detected up to 5\,TeV, and its spectrum is well-represented by a power-law function with spectral index of $2.74 \pm 0.08$. The complexity of the region makes the identification of the origin of the very-high energy emission difficult, however the spectral agreement with the LAT source and overlapping position at less than 1.5$\sigma$ point to a common origin. We analysed 8 years of \fermi-LAT data to extend the spectrum of the source down to 60\,MeV. \fermi-LAT and MAGIC spectra overlap within errors and the global broad band spectrum is described by a power-law with exponential cutoff at $1.9\pm0.5$\,TeV. The detected $\gamma$-ray emission can be interpreted as the results of proton-proton interaction between the supernova and the CO-rich surrounding., Comment: accepted for publication by MNRAS
Published: 2019

49. The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase

Author: Alexandra Cousido-Siah, Lucas A. Defelipe, Javier Santos, W.M. Valsecchi, Andre Mitschler, Alberto Podjarny, José M. Delfino, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), and Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Hypoxanthine Phosphoribosyltransferase, Stereochemistry, Trypanosoma cruzi, Proteolysis, Molecular Sequence Data, Biophysics, Protein Data Bank (RCSB PDB), Biochemistry, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Biopolymers, [CHIM.CRIS]Chemical Sciences/Cristallography, medicine, Amino Acid Sequence, Molecular Biology, Hypoxanthine, chemistry.chemical_classification, 030102 biochemistry & molecular biology, biology, medicine.diagnostic_test, Circular Dichroism, biology.organism_classification, 030104 developmental biology, Enzyme, chemistry, Hypoxanthine-guanine phosphoribosyltransferase, Spectrophotometry, Ultraviolet, Protein quaternary structure
Abstract: Hypoxanthine phosphoribosyl transferase from Trypanosoma cruzi (TcHPRT) is a critical enzyme for the survival of the parasite. This work demonstrates that the full-length form in solution adopts a stable and enzymatically active tetrameric form, exhibiting large inter-subunit surfaces. Although this protein irreversibly aggregates during unfolding, oligomerization is reversible and can be modulated by low concentrations of urea. When the C-terminal region, which is predicted as a disordered stretch, is excised by proteolysis, TcHPRT adopts a dimeric state, suggesting that the C-terminal region acts as a main guide for the quaternary arrangement. These results are in agreement with X-ray crystallographic data presented in this work. On the other hand, the C-terminal region exhibits a modulatory role on the enzyme, as attested by the enhanced activity observed for the dimeric form. Bisphosphonates act as substrate-mimetics, uncovering long-range communications among the active sites. All in all, this work contributes to establish new ways applicable to the design of novel inhibitors that could eventually result in new drugs against parasitic diseases.
Published: 2016

50. Unraveling the Complex Behavior of Mrk 421 with Simultaneous X-Ray and VHE Observations during an Extreme Flaring Activity in 2013 April

Author: Simonetta Puccetti, D. Dominis Prester, M. Makariev, Alice Donini, Sofia O. Kurtanidze, G. Bonnoli, Julian Sitarek, D. Dorner, Yoshiki Ohtani, J. Becerra González, S. Ventura, S. Ansoldi, L. Nogués, J. Besenrieder, A. Rugliancich, P. Munar-Adrover, Jose Luis Contreras, B. Jordan, I. Puljak, Pawel Gliwny, L. V. Larionova, L. Di Venere, Sunay Ibryamov, Abelardo Moralejo, M. I. Martínez, B. De Lotto, Juan Cortina, A. A. Mokrushina, E. Moretti, Kaya Mori, Maria Petropoulou, Elena G. Larionova, J. Rico, Juan Abel Barrio, Narek Sahakyan, A. Fattorini, C. Fruck, F. Del Puppo, F. Verrecchia, Victoria Moreno, Chiara Righi, M. V. Fonseca, Elina Lindfors, Justin D. Finke, D. A. Morozova, V. D'Elia, A. López-Oramas, M. G. Nikolashvili, John Hoang, Susumu Inoue, L. Maraschi, R. Paoletti, R. Reinthal, A. Strigachev, Saverio Lombardi, T. Schweizer, E. Do Souto Espiñeira, Tomislav Terzić, Ferdinando Giordano, Fabrizio Tavecchio, C. Nigro, B. Banerjee, Bernd Schleicher, A. Hahn, R. G. Chanishvili, Francesco Longo, M. Will, Shunsuke Sakurai, Ll. Font, Takeshi Oka, Davide Depaoli, Alan P. Marscher, L. Saha, D. Elsaesser, Antonio Stamerra, R. Carosi, G. Ceribella, Joni Tammi, V. Fallah Ramazani, D. Lelas, T. Guever, M. Teshima, J. M. Paredes, Dorota Sobczyńska, Zeljka Bosnjak, Chakali Eswaraiah, A. C. R. Readhead, G. Busetto, Jorge Otero-Santos, Mislav Baloković, J. L. Richards, R. A. Chigladze, Y. Chai, J. Kushida, Seiya Nozaki, Kari Nilsson, U. Barres de Almeida, L. Foffano, Ciro Bigongiari, Saša Mićanović, V. Vitale, Wen Ping Chen, P. Temnikov, T. Saito, Andrei Berdyugin, David H. Green, D. Strom, F. Di Pierro, E. N. Kopatskaya, Stefano Covino, D. Miceli, S. Gasparyan, D. Blinov, G. Maneva, E. Molina, S. G. Jorstad, T. Surić, M. Mariotti, I. Šnidarić, Satoshi Fukami, H. Kubo, M. Vazquez Acosta, R. López-Coto, Kazuma Ishio, Y. Iwamura, M. Gaug, A. Lamastra, A. C. Sadun, J. Herrera, G. Vanzo, Oscar Blanch, T. S. Grishina, Walter Max-Moerbeck, Anne Lähteenmäki, S. M. Colak, Valeri M. Larionov, C. M. Raiteri, C. Maggio, O. M. Kurtanidze, S. Cikota, D. Ninci, G. Ferrara, A. De Angelis, Rumen Bachev, Yu. V. Troitskaya, M. Minev, Georgi Latev, Elisa Bernardini, Other groups, L. Pavletić, Elisa Prandini, Goran Damljanović, Evgeni Semkov, M. Delfino, Wolfgang Rhode, Yusuke Suda, Massimo Persic, Carlo Vigorito, A. Berti, Paul S. Smith, K. Noda, Dario Hrupec, C. Leto, Victor A. Acciari, K. Nishijima, B. Machado de Oliveira Fraga, Mitsunari Takahashi, P. Peñil, L. Bellizzi, Serena Loporchio, Jose Miguel Miranda, N. Godinović, M. Strzys, Ashot Chilingarian, N. Giglietto, U. Colin, W. Bednarek, Simone Mender, Moritz Hütten, W. Bhattacharyya, I. Agudo, R. Mirzoyan, Louis Antonelli, Dominik Baack, P. Majumdar, G. M. Madejski, A. Arbet Engels, Vitaly Neustroev, J. W. Moody, Luca Tosti, M. Villata, D. Morcuende, N. Torres-Albà, I. Vovk, Jordi Delgado, H. C. Lin, Kevin Schmidt, Talvikki Hovatta, D. Hadasch, M. Palatiello, Y. Kajiwara, Francesco Dazzi, M. Mallamaci, O. Vince, M. Peresano, Yosuke Kobayashi, P. Da Vela, F. D'Ammando, K. Mannheim, R. J. García López, Ivan S. Troitsky, Tjark Miener, David Paneque, A. Biland, Marina Manganaro, P. G. Prada Moroni, Merja Tornikoski, Matteo Cerruti, M. López, Konstancja Satalecka, D. Mazin, Michele Doro, J. Barnes, F. Leone, M. Ribó, J. van Scherpenberg, A. Babić, Alessia Spolon, Léa Jouvin, Manasvita Joshi, Vassil Verguilov, Daniel Kerszberg, V. Ramakrishnan, D. Zarić, Tomohiro Inada, E. Colombo, M. Perri, M. Garczarczyk, Federal Ministry of Education and Research (Germany), Istituto Nazionale di Astrofisica, Swiss National Science Foundation, Istituto Nazionale di Fisica Nucleare, Ministerio de Economía y Competitividad (España), European Commission, Department of Atomic Energy (India), Ministry of Education, Culture, Sports, Science and Technology (Japan), Japan Society for the Promotion of Science, Ministry of Education, Youth and Science (Bulgaria), Academy of Finland, Croatian Science Foundation, University of Rijeka, German Research Foundation, National Centre for Research and Development (Poland), Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, National Aeronautics and Space Administration (US), Department of Energy (US), Centre National de la Recherche Scientifique (France), Russian Science Foundation, Gordon and Betty Moore Foundation, John Templeton Foundation, Shota Rustaveli National Science Foundation, Comisión Nacional de Investigación Científica y Tecnológica (Chile), Metsähovi Radio Observatory, Department of Electronics and Nanoengineering, Aalto-yliopisto, Aalto University, Magic, Collaboration, Other Groups And, Collaborator, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Engels, A. A., Baack, D., Babic, A., Banerjee, B., De Almeida, U. B., Barrio, J. A., Gonzalez, J. B., Bednarek, W., Bellizzi, L. K., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bosnjak, Z., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Elia, V., Vela, P. D., Dazzi, F., Angelis, A. D., Lotto, B. D., Puppo, F. D., Delfino, M., Delgado, J., Depaoli, D., Pierro, F. D., Venere, L. D., Souto Espiñeira, E. D., Prester, D. D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Ramazani, V. F., Fattorini, A., Ferrara, G., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Lopez, R. J. G., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinovic, N., Green, D., Hadasch, D., Hahn, A., Hassan, T., Herrera, J., Hoang, J., Hrupec, D., Hutten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kajiwara, Y., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lopez-Coto, R., Lopez-Oramas, A., Loporchio, S., De Oliveira Fraga, B. M., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Mazin, D., Mender, S., Micanovic, S., Miceli, D., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletic, L., Peñil, P., Peresano, M., Persic, M., Moroni, P. G. P., Prandini, E., Puljak, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suric, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Torres-Alba, N., Tosti, L., Scherpenberg, J. V., Vanzo, G., Acosta, M. V., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Zaric, D., Petropoulou, M., Finke, J., D'Ammando, F., Balokovic, M., Madejski, G., Mori, K., Puccetti, S., Leto, C., Perri, M., Verrecchia, F., Villata, M., Raiteri, C. M., Agudo, I., Bachev, R., Berdyugin, A., Blinov, D. A., Chanishvili, R., Chen, W. P., Chigladze, R., Damljanovic, G., Eswaraiah, C., Grishina, T. S., Ibryamov, S., Jordan, B., Jorstad, S. G., Joshi, M., Kopatskaya, E. N., Kurtanidze, O. M., Kurtanidze, S. O., Larionova, E. G., Larionova, L. V., Larionov, V. M., Latev, G., Lin, H. C., Marscher, A. P., Mokrushina, A. A., Morozova, D. A., Nikolashvili, M. G., Semkov, E., Smith, P. S., Strigachev, A., Troitskaya, Y. V., Troitsky, I. S., Vince, O., Barnes, J., Guver, T., Moody, J. W., Sadun, A. C., Hovatta, T., Richards, J. L., Max-Moerbeck, W., Readhead, A. C. S., Lahteenmaki, A., Tornikoski, M., Tammi, J., Ramakrishnan, V., and Reinthal, R.
Subjects: Individual sources Mrk 421, Flux, Astrophysics, Blazar, 7. Clean energy, 01 natural sciences, Imaging Atmospheric Cherenkov observations, Gamma-ray, Active galaxie, Relativistic jet, MAGIC (telescope), BL lacertae objects, BL Lacertae objects, Blazars, Active galaxies, Markarian galaxies, Gamma-ray detectors, Gamma-rays, Relativistic jets, High energy astrophysics, Observational astronomy, 010303 astronomy & astrophysics, astro-ph.HE, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, Gamma ray, X-ray, Markarian galaxie, Física nuclear, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics and Astronomy, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics - High Energy Astrophysical Phenomena, Individual sources Mrk 421, Imaging Atmospheric Cherenkov observations, MAGIC, BL Lacertae objects, Blazars, Active galaxies, Markarian galaxies, Gamma-ray detectors, Gamma-rays, Relativistic jets, High energy astrophysics, Observational astronomy, Plasmoid, Astrophysics::Cosmology and Extragalactic Astrophysics, BL Lacertae object, High energy astrophysic, 0103 physical sciences, Gamma-ray detector, 010308 nuclear & particles physics, Astronomy and Astrophysics, Magnetic reconnection, Light curve, MAGIC, 13. Climate action, Space and Planetary Science, ddc:520, High Energy Astrophysical Phenomena
Abstract: We report on a multiband variability and correlation study of the TeV blazar Mrk 421 during an exceptional flaring activity observed from 2013 April 11 to 19. The study uses, among others, data from GLAST-AGILE Support Program (GASP) of the Whole Earth Blazar Telescope (WEBT), Swift, Nuclear Spectroscopic Telescope Array (NuSTAR), Fermi Large Area Telescope, Very Energetic Radiation Imaging Telescope Array System (VERITAS), and Major Atmospheric Gamma Imaging Cherenkov (MAGIC). The large blazar activity and the 43 hr of simultaneous NuSTAR and MAGIC/VERITAS observations permitted variability studies on 15 minute time bins over three X-ray bands (3-7 keV, 7-30 keV, and 30-80 keV) and three very-high-energy (VHE; >0.1 TeV) gamma-ray bands (0.2-0.4 TeV, 0.4-0.8 TeV, and >0.8 TeV). We detected substantial flux variations on multi-hour and sub-hour timescales in all of the X-ray and VHE gamma-ray bands. The characteristics of the sub-hour flux variations are essentially energy independent, while the multi-hour flux variations can have a strong dependence on the energy of the X-rays and the VHE gamma-rays. The three VHE bands and the three X-ray bands are positively correlated with no time lag, but the strength and characteristics of the correlation change substantially over time and across energy bands. Our findings favor multi-zone scenarios for explaining the achromatic/chromatic variability of the fast/slow components of the light curves, as well as the changes in the flux-flux correlation on day-long timescales. We interpret these results within a magnetic reconnection scenario, where the multi-hour flux variations are dominated by the combined emission from various plasmoids of different sizes and velocities, while the sub-hour flux variations are dominated by the emission from a single small plasmoid moving across the magnetic reconnection layer. © 2020. The American Astronomical Society. All rights reserved., The financial support of the German BMBF and MPG, the Italian INFN and INAF, the Swiss National Fund SNF, the ERDF under the Spanish MINECO (FPA2017-87859-P, FPA2017-85668-P, FPA2017-82729-C6-2-R, FPA2017-827 29-C6-6-R, FPA2017-82729-C6-5-R, AYA2015-71042-P, AYA2016-76012-C3-1-P, ESP2017-87055-C2-2-P, and FPA 201790566REDC), the Indian Department of Atomic Energy, the Japanese JSPS and MEXT, the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO-1153/28.08.2018 and the Academy of Finland grant No. 320045 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia "Severo Ochoa" SEV-20160588 and SEV-2015-0548, and Unidad de Excelencia "Maria de Maeztu" MDM-2014-0369, by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3, the Polish National Research Centre grant UMO-2016/22/M/ST9/00382, and by the Brazilian MCTIC, CNPq and FAPERJ. The Fermi-LAT.Collaboration acknowledges generous ongoing support from a number of agencies and institutes that have supported both the development and the operation of the LAT as well as scientific data analysis. These include the National Aeronautics and Space Administration and the Department of Energy in the United States, the Commissariat a l'Energie Atomique and the Centre National de la Recherche Scientifique/Institut National de Physique Nucleaire et de Physique des Particules in France, the Agenzia Spaziale Italiana and the Istituto Nazionale di Fisica Nucleare in Italy, the Ministry of Education, Culture, Sports, Science and Technology (MEXT), High Energy Accelerator Research Organization (KEK), and Japan Aerospace Exploration Agency (JAXA) in Japan, and the K..A..Wallenberg Foundation, the Swedish Research Council, and the Swedish National Space Board in Sweden. Additional support for science analysis during the operations phase is gratefully acknowledged from the Istituto Nazionale di Astrofisica in Italy and the Centre National d'Etudes Spatiales in France. This work made use of data from the NuSTAR mission, a project led by the California Institute of Technology, managed by the Jet Propulsion Laboratory, and funded by the National Aeronautics and Space Administration. We thank the NuSTAR Operations, Software, and Calibration teams for support with the execution and analysis of these observations. This research has made use of the NuSTAR Data Analysis Software (NuSTARDAS) jointly developed by the ASI Science Data Center (ASDC; Italy) and the California Institute of Technology (USA). D.P. and A.B. are grateful to Amy Furniss and Wystan Benbow for providing the VERITAS VHE gamma-ray fluxes and for useful discussions about them. M.P. acknowledges support from the Lyman Jr. Spitzer Postdoctoral Fellowship and NASA Fermi grant No. 80NSSC18K1745., and J.F. is partially supported by NASA under contract S-15633Y. M.B. acknowledges support from NASA Headquarters under the NASA Earth and Space Science Fellowship Program (grant NNX14AQ07H) and the black hole Initiative at Harvard University, which is funded in part by the Gordon and Betty Moore Foundation (grant GBMF8273) and in part by the John Templeton Foundation. This research was partially supported by the Bulgarian National Science Fund of the Ministry of Education and Science under grants DN 18-13/2017, DN 18-10/2017, KP06-H28/3 (2018), and KP-06-PN38/1 (2019), as well as for the Spanish MIMECO (AYA2016-80889-P, RYC-2013-14511) and the IAA-CSIC "Severo Ochoa" program SEV2017-0709. The St. Petersburg University team acknowledges support from Russian Science Foundation grant 17-12-01029. The Abastumani team acknowledges financial support of the project FR/638/6-320/12 by the Shota Rustaveli National Science Foundation under contract 31/77. T.G. acknowledges support from Istanbul University (Project numbers 49429 and 48285), Bilim Akademisi (BAGEP program), and TUBITAK (project numbers 13AT100-431, 13AT100-466, and 13AT60-430). The Boston University effort was supported in part by NASA grants NNX12AO90G and NNX14AQ58G. Data from the Steward Observatory spectropolarimetric monitoring project were used in this paper. This program is supported by Fermi Guest Investigator grants NNX08AW56G, NNX09 AU10G, NNX12AO93G, and NNX15AU81G. The OVRO 40 m monitoring program is supported in part by NASA grants NNX08AW31G and NNX11A043G and NSF grants AST-0808050 and AST-1109911. The Metsahovi team acknowledges the support from the Academy of Finland to our observing projects (numbers 212656, 210338, 121148, and others). W.M. acknowledges support from CONICYT project Basal AFB-170002.
Published: 2020

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