1. Local control of rhino-orbito-cerebral mucormycosis dramatically impacts survival
- Author
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O. Lortholary, Dea Garcia-Hermoso, Philippe Herman, Caroline Elie, Romain Kania, P. Vironneau, Fanny Lanternier, Gloria Morizot, Service d'oto-rhino-laryngologie, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Lariboisière, Centre National de Référence des Mycoses invasives et antifongiques - Mycologie moléculaire (CNRMA), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Service des Maladies infectieuses et tropicales [CHU Necker], Université Paris Descartes - Paris 5 (UPD5)-CHU Necker - Enfants Malades [AP-HP]-Institut des Maladies Génétiques Imagine [Paris], CHU Necker - Enfants Malades [AP-HP], Appendix 1. Members of the French Mycosis Study Group and ENT surgeons in this study Besançon (A. Dussaucy, J.F. Viel, F. Grenouillet, G. Blasco, F. Legrand, J. C. Navellou, E. Plouvier, L. Tavernier, B. Kantelip), Bordeaux (A. Kostrzewa, B. Couprie, J. P. Bebear, E. Blanchart, L. De Gabory, M. Dupon, C. Deminière), Dijon (C. Quantin, D. Caillot, C. Duvillard), Nice (G. Daideri, M. Gari-Toussaint, H. Hyvernat, M. Poiree, P. M. Roger), Nimes (C. Lechiche, L Lachaud), Perpignan (M. Saada, C. Billotet, J.M. Lopez), Rennes (A. Fresnel, X. Carsin, J. P. Gangneux, C. Arvieux, T. Lamy de la Chapelle, N. Rioux), Toulouse (L. Molinier, S. Cassaing, M. Alvarez, L. Esposito, B. Marchou, X. Brousset, E. Uro-Coste, E. Serrano). Those in Paris are as follows: Bichat (C. Chochillon, O. Brugière, M. Wolff, V. Joly, H. Adle- Biassette), Lariboisière (T. Meas, R. Kania, P.Herman, E. Sauvaget), Necker (C. Lebihan, M. E. Bougnoux), Pitié Salpétrière (A. Fekkar, A. Datry, L. Bodin, Y. Samson), Saint-Louis (C. Lacroix, P. Ribaud, A. Xhaard, A. Bergeron-Lafaurie, O. Marie, J. Pavie, E. Raffoux)., Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Male ,MESH: Combined Modality Therapy ,Antifungal Agents ,MESH: Skull Base ,MESH: Brain Diseases ,MESH: Paranasal Sinus Diseases ,Rhino orbito cerebral mucormycosis ,mucormycosis ,necrosis ,surgery ,0302 clinical medicine ,MESH: Aged, 80 and over ,MESH: Bone Diseases, Infectious ,Orbital Diseases ,030212 general & internal medicine ,Sinusitis ,[SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology ,Aged, 80 and over ,Skull Base ,MESH: Aged ,Brain Diseases ,0303 health sciences ,MESH: Middle Aged ,General Medicine ,Middle Aged ,Bone Diseases, Infectious ,Combined Modality Therapy ,3. Good health ,Survival Rate ,Infectious Diseases ,MESH: Young Adult ,Female ,Adult ,Microbiology (medical) ,medicine.medical_specialty ,MESH: Survival Rate ,sinusitis ,Young Adult ,03 medical and health sciences ,Paranasal Sinus Diseases ,medicine ,Humans ,MESH: Debridement ,Reference standards ,Aged ,Retrospective Studies ,MESH: Mucormycosis ,MESH: Humans ,MESH: Orbital Diseases ,030306 microbiology ,business.industry ,Mucormycosis ,MESH: Adult ,MESH: Retrospective Studies ,Surgical procedures ,medicine.disease ,MESH: Antifungal Agents ,MESH: Male ,Surgery ,Debridement ,Local control ,business ,MESH: Female - Abstract
International audience; Surgery and antifungals are the reference standard for rhino-orbito-cerebral mucormycosis (ROCM) treatment. The impact of local control on survival of 22 consecutive ROCM adults was studied on day 90: none vs. 75% died, respectively, with or without local control (p
- Published
- 2014
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