1. The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases
- Author
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Gregory Conductier, Nicolas Blondeau, Alice Guyon, Carole Rovère, Jean-Louis Nahon, Institut de pharmacologie moléculaire et cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)
- Subjects
CCR2 ,Chemokine ,MESH: Chemotaxis, Leukocyte ,0302 clinical medicine ,Neuroinflammation ,MESH: Receptors, CCR2 ,Immunology and Allergy ,MESH: Animals ,Chemokine CCL2 ,0303 health sciences ,biology ,Brain ,Alzheimer's disease ,3. Good health ,Stroke ,Chemotaxis, Leukocyte ,Neurology ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,medicine.symptom ,Chemokines ,CCL2 ,Monocyte Chemoattractant Proteins ,Multiple Sclerosis ,Receptors, CCR2 ,Immunology ,Inflammation ,MESH: Strok ,Lesion ,03 medical and health sciences ,MESH: Brain ,Immune system ,Alzheimer Disease ,medicine ,Animals ,Humans ,MESH: Chemokine CCL2 ,030304 developmental biology ,MESH: Humans ,business.industry ,Multiple sclerosis ,MESH: Multiple Sclerosis ,medicine.disease ,biology.protein ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,MESH: Alzheimer Disease - Abstract
International audience; Inflammatory response represents one of the first immune processes following injury. It is characterized by the production of various molecules that initiate the recruitment of immune cells to the lesion sites, including in the brain. Accordingly, in acute brain trauma, such as stroke, as well as during chronic affections like multiple sclerosis or Alzheimer's disease, inflammation occurs in order to "clean up" the lesion and to limit its area. Nevertheless, prolonged and sustained inflammation may have cytotoxic effects, aggravating the incidence and the severity of the disease. Among molecules produced during inflammation associated to neuronal death, monocyte chemoattractant proteins (MCPs) seem to be particularly important. This review will focus on the current knowledge about one of the MCPs, CCL2, and its cognate receptor, CCR2, both expressed in physiological conditions and during neurodegenerative diseases.
- Published
- 2010