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2. A Synthesis of 1,4-Disubstituted Imidazolidin-2-ones from Fused-Ring Aziridines.

Author

Maciagiewicz, Iwona M., Fang, Fang, Roberts, Dennis A., Shu Zhou, Hines, Jennifer V., and Bergmeier, Stephen C.

Subjects
*PHARMACEUTICAL research, *ANTIBACTERIAL agents, *CATALYSIS, *AMINO acids, *IMIDAZOLES
Abstract

As part of an antibacterial drug discovery project, we were interested in preparing bioisosteric replacement analogues of 4,5-disubstituted oxazolidinones. One such isosteric replacement is the imidazolidinone ring system. Here, we report the development of a general synthesis of 1,4-disubstituted imidazolidinones that takes advantage of the base-catalyzed rearrangement of amino-methyl-substituted oxazolidinones. [ABSTRACT FROM AUTHOR]

Published
2012
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