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Abstract Proximal femoral fractures are a serious life-threatening injury with high morbidity and mortality. Magnetic resonance (MR) imaging has potential to non-invasively assess proximal femoral bone strength in vivo through usage of finite element (FE) modelling (a technique referred to as MR-FE). To precisely assess bone strength, knowledge of measurement error associated with different MR-FE outcomes is needed. The objective of this study was to characterize the short-term in vivo precision errors of MR-FE outcomes (e.g., stress, strain, failure loads) of the proximal femur for fall and stance loading configurations using 13 participants (5 males and 8 females; median age: 27 years, range: 21–68), each scanned 3 times. MR-FE models were generated, and mean von Mises stress and strain as well as principal stress and strain were calculated for 3 regions of interest. Similarly, we calculated the failure loads to cause 5% of contiguous elements to fail according to the von Mises yield, Brittle Coulomb-Mohr, normal principal, and Hoffman stress and strain criteria. Precision (root-mean squared coefficient of variation) of the MR-FE outcomes ranged from 3.3% to 11.8% for stress and strain-based mechanical outcomes, and 5.8% to 9.0% for failure loads. These results provide evidence that MR-FE outcomes are a promising non-invasive technique for monitoring femoral strength in vivo.

Kabuki Syndrome (KS) encompasses a spectrum of clinical manifestations, primarily attributed to pathogenic variants in the KMT2D gene. This study aims to elucidate novel features in KS patients with missense variants, contrasting their presentation with both literature-reported cases of patients with missense pathogenic variants as well as other KS patients with truncating pathogenic variants. Employing a survey questionnaire and clinical evaluations, we examined ten KS patients with missense variants, focusing on their dysmorphism characteristics, behavior and psychomotor development. We identified unique features in missense variant patients, including foot hyperesthesia, musicality, and sensory integration disorders. Notably, despite similarities in developmental trajectories, distinct phenotypic traits emerged in missense variant cases, suggesting a potential genotype-phenotype correlation. These findings contribute to a deeper understanding of KS heterogeneity and underscore the importance of genotype-specific characterization for prognostic and therapeutic considerations. Further exploration of genotype-phenotype relationships promises to refine clinical management strategies and enhance patient outcomes in this complex syndrome.

The present article contains an introduction (describing problems in the study of microhistory and distinguishing groups interested in these types of considerations), the characteristics of interviews and written papers and the conclusions drawn from them. The basis for its creation was the “My Family” Project, consisting of three elements: students’ written papers, a recording of an interview with a family member (preferably a grandmother or grandfather) and a presentation at a conference. The project was carried out in the summer semester of 2022 with second-year B.A. students at the Institute of History of the Jan Kochanowski University in Kielce as part of “The historian’s research methods” classes. Students involved in this initiative also took part in a conference entitled “My Family as an Archival Source” (as part of the “Meetings with an Archival Source” series), which took place on September 28, 2022. A report on this event was written by one of the students participating in the project. The first part of the project consisted of student interviews with family members. Parents and grandparents discussed topics such as the history of their ancestors, the years of German and Soviet occupation, and everyday life. The representatives of the older generation focused on telling about their experience of World War II in small towns of today’s Świętokrzyskie province, while the students’ parents discussed the dull reality of the Polish People’s Republic. The interviews concerning the occupation period were emotional; they show the savagery of the Germans murdering Polish ­civilians and indicate that historians have not yet worked through this issue. Students’ papers deal with the unique history of their ancestors. The topics discussed in them mainly concern the fate of the authors’ great-grandparents and grandparents. The texts describe the realities of Kielce villages during World War II, as well as the hardships of everyday life. The overwhelming majority of the ancestors of the students participating in the project lived in the countryside, having peasant or landowning origins. The article ends with conclusions presented by students during the discussion summarizing the project. Student papers can encourage readers to research their family’s past. Every history student should know the history of their family.

Abstract Dysregulation of hypothalamic ceramides has been associated with disrupted neuronal pathways in control of energy and glucose homeostasis. However, the specific ceramide species promoting neuronal lipotoxicity in obesity have remained obscure. Here, we find increased expression of the C16:0 ceramide-producing ceramide synthase (CerS)6 in cultured hypothalamic neurons exposed to palmitate in vitro and in the hypothalamus of obese mice. Conditional deletion of CerS6 in hypothalamic neurons attenuates high-fat diet (HFD)-dependent weight gain and improves glucose metabolism. Specifically, CerS6 deficiency in neurons expressing pro-opiomelanocortin (POMC) or steroidogenic factor 1 (SF-1) alters feeding behavior and alleviates the adverse metabolic effects of HFD feeding on insulin sensitivity and glucose tolerance. POMC-expressing cell-selective deletion of CerS6 prevents the diet-induced alterations of mitochondrial morphology and improves cellular leptin sensitivity. Our experiments reveal functions of CerS6-derived ceramides in hypothalamic lipotoxicity, altered mitochondrial dynamics, and ER/mitochondrial stress in the deregulation of food intake and glucose metabolism in obesity.

Abstract Design of metallosupramolecular materials encompassing more than one kind of supramolecular interaction can become deceptive, but it is necessary to better understand the concept of the controlled formation of supramolecular systems. Herein, we show the structural diversity of the bis-compartmental phenoxo-benzimidazole ligand H3 L 1 upon self-assembly with variety of d-block metal ions, accounting for factors such as: counterions, pH, solvent and reaction conditions. Solid-state and solution studies show that the parent ligand can accommodate different forms, related to (de)protonation and proton-transfer, resulting in the formation of mono-, bi- or tetrametallic architectures, which was also confirmed with control studies on the new mono-compartmental phenoxo-benzimidazole H2 L 2 ligand analogue. For the chosen architectures, structural variables such as porous character, magnetic behaviour or luminescence studies were studied to demonstrate how the form of H3 L 1 ligand affects the final form of the supramolecular architecture and observed properties. Such complex structural variations within the benzimidazole-phenoxo-type ligand have been demonstrated for the first time and this proof-of-concept can be used to integrate these principles in more sophisticated architectures in the future, combining both the benzimidazole and phenoxide subunits. Ultimately, those principles could be utilized for targeted manipulation of properties through molecular tectonics and crystal engineering aspects.

The design of an aircraft’s internal structure, and therefore the appropriate choice of material type, is a direct function of the performed tasks and the magnitude and type of the acting loads. The design of a durable aircraft structure with appropriate stiffness and lightness requires knowledge of the loads that will be applied to the structure. Therefore, this paper presents the results of an aerodynamic experimental test and numerical analysis of a newly designed jet-propelled aerial target. The experimental tests were carried out in a low-speed wind tunnel for a wide range of angles of attack and sideslips. Moreover, they were performed for various configurations of the airplane model. In addition, the results of the experimental test were supplemented with the results of the numerical analysis performed using computational fluid dynamics methods. During numerical analysis, specialized software based on solving partial differential equations using the Finite Volumes Method was used. This article presents the methodology of the conducted research. The results of the aerodynamic analysis are presented in the form of diagrams showing the aerodynamic force and moment components as a function of the angle of attack and sideslip. In addition, qualitative results of the flow around the plane have been presented. The results obtained prove that the adopted methods are sufficient to solve these types of problem. The aerial system was positively verified during the qualification tests of the system at the Polish Air Force training range and finally received the type certificate.

Abstract Cerebral small vessel disease is characterised by decreased cerebral blood flow and blood–brain barrier impairments which play a key role in the development of white matter lesions. We hypothesised that cerebral hypoperfusion causes local hypoxia, affecting oligodendrocyte precursor cell—endothelial cell signalling leading to blood–brain barrier dysfunction as an early mechanism for the development of white matter lesions. Bilateral carotid artery stenosis was used as a mouse model for cerebral hypoperfusion. Pimonidazole, a hypoxic cell marker, was injected prior to humane sacrifice at day 7. Myelin content, vascular density, blood–brain barrier leakages, and hypoxic cell density were quantified. Primary mouse oligodendrocyte precursor cells were exposed to hypoxia and RNA sequencing was performed. Vegfa gene expression and protein secretion was examined in an oligodendrocyte precursor cell line exposed to hypoxia. Additionally, human blood plasma VEGFA levels were measured and correlated to blood–brain barrier permeability in normal-appearing white matter and white matter lesions of cerebral small vessel disease patients and controls. Cerebral blood flow was reduced in the stenosis mice, with an increase in hypoxic cell number and blood–brain barrier leakages in the cortical areas but no changes in myelin content or vascular density. Vegfa upregulation was identified in hypoxic oligodendrocyte precursor cells, which was mediated via Hif1α and Epas1. In humans, VEGFA plasma levels were increased in patients versus controls. VEGFA plasma levels were associated with increased blood–brain barrier permeability in normal appearing white matter of patients. Cerebral hypoperfusion mediates hypoxia induced VEGFA expression in oligodendrocyte precursor cells through Hif1α/Epas1 signalling. VEGFA could in turn increase BBB permeability. In humans, increased VEGFA plasma levels in cerebral small vessel disease patients were associated with increased blood–brain barrier permeability in the normal appearing white matter. Our results support a role of VEGFA expression in cerebral hypoperfusion as seen in cerebral small vessel disease.

Introduction Over past decades the number of patients suffering from psychiatric disorders all around the world is constantly increasing. Thank to general awareness and less stigmatization people seek for specialist’s help more willingly. Recently, one of the most common diagnoses has been anxiety disorder and many of them also tend to abuse alcohol. So far, scientists have focused mostly on alcoholism as a consequence of anxiety disorder, due to patients’ predilection to addictions. However, ethanol can also trigger anxiety itself. Aim of the study The aim of this study is to summarize the current state of knowledge on the role of alcohol in anxiety disorder development and its pathomechanisms. Material and methods This article is based on available publications in Pubmed and Google Scholar databases. Conclusions Excessive alcohol consumption may lead to the development of anxiety disorder in some patients, as well as, many other psychiatric disturbances. However, further research must be done to find out precise pathomechanism responsible for those states.

Introduction: Physical activity in pregnant women, as in the rest of the population, helps to maintain good health and prevent diseases. It has a positive effect on the body of the future mother, but is also a source of measurable benefits for the developing fetus. There are many methods of active spending time for pregnant women that are not only safe but also recommended to ensure the proper course of pregnancy. Aim of the study: The aim of our study is to present current recommendations regarding activity among pregnant women and the benefits for the mother and fetus resulting from regular and moderate physical activity. Material and methods: We reviewed scientific publications using the Google Scholar database, using keywords such as “physical activity during pregnancy” or “physical activity among pregnant women”. Conclusions: Physical activity in pregnant women is not only safe but also recommended. According to the recommendations, pregnant women should exercise regularly in a way that is not too strenuous and does not pose a risk of injury. Regular, moderate activity during pregnancy brings a number of benefits for the pregnant woman and the fetus.

Introduction: Sleep is a fundamental biological need of the body, crucial for maintaining health and body’s regeneration. The body position during sleep not only affects sleep quality and well-being but also influences various health aspects, such as obstructive sleep apnea, back pain or gastroesophageal reflux. Aim of the study: The aim of our study is to summarize the impact of body position during sleep on human health. We paid attention to the relationship between sleep position and aspects like: sleep quality, obstructive sleep apnea, back pain and gastroesophageal reflux. State of knowledge: The body position during sleep is crucial for maintaining mental and physical health. It affects sleep quality as well as health aspects such as: obstructive sleep apnea, back pain or gastroesophageal reflux disease. In the case of sleep quality, the most beneficial position is on the right side. The supine position is associated with worsened obstructive sleep apnea, while on the side - with reducing the frequency of symptoms. Neck pain is connected with an asymmetrical side and an upright head position, while lower back pain is associated with a supine position. The described position that reduces the reflux of gastric contents into the esophagus, and thus reduces the symptoms of reflux disease, is on the left side and with an elevated head of the bed. Summary: Sleep position is significant for many aspects of human health. Besides affecting sleep quality and well-being, it also has an impact on conditions such as obstructive sleep apnea, back pain and gastroesophageal reflux.

Introduction: Food allergies are becoming an increasingly significant challenge for medicine, public health and patients' quality of life. Over the past few decades, there has been an observed increase in the number of cases of food allergies. This has led to heightened interest among scientists, doctors and specialists in various aspects related to the diagnosis and treatment of this condition. With the increasing precision of food allergy diagnosis, it is necessary to adjust the therapy to the individual needs of patients. Aim of the study: The aim of our study is to summarize the trends and challenges in treatment and diagnosis of food allergies. We focused on current diagnostic methods and treatment options, as well as new promising therapeutic approaches. State of knowledge: In molecular or component-resolved diagnostic tests (CRD), specific IgE antibodies are measured for individual food allergenic molecules. This presents an opportunity to improve specificity for selected foods. Studies have shown that the Basophil Activation Test (BAT) exhibits higher specificity than skin prick tests (SPT) and s-IgE tests, while maintaining its sensitivity. BAT relies on flow cytometry, where the expression of activation markers on the surface of basophils stimulated by an antigen is measured. Due to the existing limitations of certain tests, Oral Food Challenge (OFC) is still considered the gold standard for diagnosing IgE-mediated food allergies. Summary: Research shows that the foundation of diagnosis is the patient's medical history, including a properly collected interview, which should then guide the doctor towards appropriate tests. An elimination diet based on the clinical interview should be implemented until significant relief of allergy symptoms is achieved.

Introduction: Growing development of obstetrics and gynecology was followed by a decrease in the frequency of operative vaginal deliveries. This occurrence has been observed over the years, coming hand in hand with an increasing popularity of caesarean sections. Operative vaginal deliveries include vacuum deliveries and forceps deliveries, which both may be an alternative to some cases of emergency caesarean sections. Aim of the study: The aim of our study was to depict the most important aspects of operative vaginal deliveries, analyze their complications, and to try to compare the consequences of mentioned techniques. Careful analysis of these issues can facilitate the decision-making process in obstetric practice. Materials and methods: A review of the current literature was made in the accessible PubMed and Google Scholar database, using the keywords: „operative vaginal deliveries”, „forceps delivery”, „vacuum delivery”. Moreover, textbooks concerning obstetrics and gynecology were reviewed in terms of operative vaginal deliveries. Conclusions: Both forceps and vacuum deliveries have variety of uses, especially in cases of slowed progress of the second stage of labor. They both have distinct differences, the analysis of which may help the obstetrician to choose the best possible method for each case. These techniques may prove to be a useful tool in preventing unnecessary caesarean sections and their complications, especially when performed by experienced doctors.

Introduction: Constipation is identified as too few bowel movements (≤2/week; severe constipation is ≤2 bowel movements per month) or hard stools (Bristol Formation Scale 1 and 2) that are passed with effort, often with a sensation of incomplete defecation . Purpose of study: The aim of this review is to present key aspects of constipation, including epidemiology, diagnosis, management and clinical treatment directed to the individual patient and individual therapy. Materials and methods: The review was based on the available literature in the PubMed database and the Google Scholar search engine using the key words: "constipation"; “constipation diagnosis”; “constipation treatment”. Conclusions: Constipation is a common health problem that affects people of all ages. It is the most frequently reported ailment in gastroenterological practice. Not only are they a cause of patient discomfort, but they are often an alarming symptom of a larger pathology in the human body. Correct diagnosis often includes multi-aspect diagnostics, in which doctors of various specialties are involved, and correct treatment significantly improves the quality of life of patients.

Introduction: Syphilis is a systemic disease caused by Treponema pallidum. Humans are the only hosts, and the incubation period lasts from 9-90 days. Currently it can be divided into congenital or acquired. This division is due to the moment in which the infection occurred. Congenital Syphilis- when the infection happens during the prenatal period, whereas acquired, when the infection took place in the period after birth. In early acquired syphilis the I and II stages can be distinguished as well as early latent syphilis. As defined, early latent syphilis includes an acquired infection up to 1 or 2 years back, depending on the guidelines. Late syphilis however includes: late latent syphilis, tertiary syphilis, late cardiovascular syphilis, late neurosyphilis. Congenital syphilis has also been divided into early (which includes the first 2 years) as well as late, which is characterised by signs of congenital syphilis, the so-called stigmata of congenital syphilis constituting the untreated infection during the fetal stage or the infancy stage. Aim of the Study: The aim of our study is to divert the attention to one of the sexually transmitted diseases, which despite the downward trend at the end of the 20th century, rebounded at the beginning of the 21st century, especially among men who have sexual contact with other men. We paid attention to the symptoms accompanying this disease, also in the context of congenital syphilis, as well as the different methods of pharmacological treatment according to European guidelines. Materials and methods: Reviewed literature available at scientific articles , Google Scholar using keywords: “syphilis – epidemiology”, “syphilis treatment”, “symptoms of syphilis”, as well as European guidelines regarding the treatment of syphilis.

Introduction: The development of medicine and information technology in recent decades has undoubtedly contributed to improving public health. Artificial intelligence is a technology that has great potential to revolutionize the functioning of health care around the world. Appropriate use of the development of technology can revolutionize many areas of modern medicine, however, it should not be forgotten that this technology should be subjected to appropriate standardization and legal regulation. Objective: The purpose of this study is to review the available scientific literature in order to systematize the current knowledge on the use of artificial intelligence in the process of diagnosis and treatment. Ethical aspects related to the implementation of AI for use in health care are also analyzed. Results: Artificial intelligence uses deep machine learning algorithms. It is a technology that has been known for a long time, but recently the chances of its widespread use have increased significantly, although scientists still do not fully understand the operation of AI algorithms. Currently, there are attempts to use this technology in many medical fields such as cardiology, diagnostic imaging, gastroenterology, pathomorphology, ultrasound. Artificial intelligence can also be used to improve the functioning of patient service in health care. Summary: The development of artificial intelligence algorithms creates a huge opportunity to improve the quality of diagnostic and treatment processes. The current rapid development of the technology is revolutionizing many branches of medicine, improving treatment outcomes. However, the development of this technology requires the creation of an appropriate law governing AI in medicine.

Introduction: Pregnancy lasts 40 weeks from the first day of the last menstrual period, i. e. 280 days or 264 days from conception. It has been established that a child born between 37+0 and 41+6 weeks of gestation is a child born "on time". Unfortunately, in some cases it is necessary to terminate the pregnancy earlier, due to the condition of the pregnant woman, the baby or the approaching 42 weeks of pregnancy. Aim of the study: The aim of our study is to summarize available options for induction of childbirth. Particular attention was paid to available pharmacology and mechanical methods. The methods were compared in terms of effectiveness, possible complications and side effects. Materials and methods: A review of the current literature was made in the accessible PubMed and Google Scholar database, using the keywords: „birth induction”, „Cook’s catether”, „prostaglandin and oxitocine induction”, „amniotomy”, „membran stripping”. Conclusions: There are several ways to induce childbirth, which are used depending on current state of pregnacy. The availability of both pharmacotherapy and mechanical methods, allows the initiation of labor and termination of pregnancy by natural forces, in most cases avoiding the need to terminate the pregnancy by caesarean section.

Introduction : Turner syndrome (TS) is one of the most common genetic disorders affecting approximatley 1 in 2,000-25000 live-born girls. TS is the result of complete oraz partial monosomy of the C chromosome. About half have monosomy X (45,X) and 5-10% have duplication (isochromosome) of the long arm of one X (46,X,i(Xq)). Most of the rest have mosaicism.(1) The aim of the study: The purpose of this review paper is to present the observations regarding this disease, including epidemiology, diagnosis and detailed examination of the individual needs of the patient affected by the disease. Matrials and methods: This review was based on available data collected in the PubMed database and Google Scholar web serach engine, using key words: Turner’s syndrome, diagnosis of Turner Syndrome, sex chromosome aneuploidies Summary: The article draws attention to the complexity of Turner syndrome, the variety of symptoms and the progress in the diagnosis and therapy of this disease. Early diagnosis, specialist care and modern therapeutic methods have a positive impact on the quality of life of TS patients. Future studies of molecular mechanisms and therapeutic efficacy may improve the care of patients affected by this rare disease.

Introduction: Prenatal diagnosis is a branch of medicine that deals with the detection of possible genetic and developmental abnormalities at the fetal life stage. Due to the rapid development of technology in recent decades, diagnostic capabilities at the prenatal stage have also changed their face. Aim of the study: The aim of the study is to review the available scientific literature in order to systematize the current knowledge of prenatal diagnosis with particular emphasis on the diagnosis of genetic diseases and diagnosis of heart defects. Results: Prenatal diagnosis is divided into invasive and non-invasive diagnostics. Non-invasive diagnostics include ultrasound, maternal blood biochemical tests and NIPT tests. Invasive diagnostics include tests such as amniocentesis and chorionic villus biopsy. Prenatal tests provide information on the risk of genetic diseases such as trisomy 21, 13 and 18 chromosome. In addition, serious structural heart defects such as tetralogy of Fallot are likely to be detected during prenatal diagnosis. Prenatal testing can also detect fetal heart rhythm abnormalities, which makes it possible to start treatment at an early stage. Modern ultrasound technology also allows 3D imaging, which can also provide valuable diagnostic information. Summary: Prenatal diagnosis is a highly developed field of medicine that combines knowledge from various specialties. Thanks to prenatal diagnosis, it is possible to detect various abnormalities at an early stage of fetal life, which enables early treatment.

In the problem of object pose estimation, one way to cope with the effect of ambiguity is to use multiple hypotheses. In this work, rather than generating the output pose based on a single object pose, our objective is to enable the system to be aware of the potential object ambiguity through maintaining multiple pose hypotheses. Firstly, we propose a pipeline for 6D object pose tracking on RGB images, wherein a key design is a fuzzy TOPSIS module that takes full advantage of multi-criteria decision making under uncertainties. Secondly, using decision variables determined on features that are frequently utilized in object pose estimation or tracking like segmented masks, fiducial keypoints, and distance transform the proposed method permits achieving tangible performance gains. An hourglass-based neural network is proposed to jointly detect object keypoints, predict the object’s non-occluded part, and to predict the object’s occluded part. To verify our designs, we conducted thorough experiments on the YCB-Video benchmark dataset. Besides, our method achieves competitive results in terms of ADD scores on the YCB-Video, showing that maintaining multiple pose hypotheses is beneficial to the task of object pose tracking. We observe that our method achieves competitive results against six recent methods estimating object pose from single frame and two SOTA object pose trackers. Extensive ablation studies verify our design choices.

Depressive disorders of antenatal and postnatal period are diagnostic challenge, as well as increasingly frequent social problem. Incidence of antenatal depression varies from 10% to 16%. Around one third of all postpartum depression cases has its beginning during the antenatal period. From the beginning of 2019, Ministry of Health’s regulations specified for the first time the recommendation to perform screening of depressive symptoms - twice during the pregnancy and once during the perinatal period, defined as the first six weeks after the delivery. Therefore the review of current studies in the subject of mental health issues during pregnancy was conducted in order to establish possible risk factors.

INTRODUCTION Social media platforms are commonly used worldwide, affecting every-day living of billions of people. It may impacts both self-esteem and self-evaluation of its users. Formed by social influence, the ideal beauty standards lead to an unhealthy comparison, need of external validation and pursuit of ideal appearance. Induced body image dissatisfaction could be the cause of many different eating disorders or rigorous exercises. Promoted by media, ideal body-image creates unhealthy focus on BMI, weight and shape of one’s own body. PURPOSE The aim of this study is to present the current state of knowledge on the impact of social media on evolving dissatisfaction with body image, followed by eating disorders. METHODS For the purposes of writing this article, the available literature was reviewed. The database of medical publications – PubMed database and publicly available books was searched, using keywords such as social media and body image disorders, eating disorders. RESULTS According to reviewed studies, spending more time on following social media intensifies body image disorders among both young women and men, as a result of negative upward comparison of their external appearance. A problematic social media use, passive and focused on image-related platforms, heightens a risk of developing a self-dissatisfaction and body concerns. Disordered eating behaviors are significantly connected to a frequent use of an image-related social media platforms. CONCLUSIONS Maintaining a healthy relationships with peers and parents protects self-esteem of adolescents and lowers the risk of body-image and eating disorders. A greater focus should be put on educating young people about their value, self-assessment and healthy relations.

Introduction Cystic fibrosis (CF) is a serious, multi-system disease. In the Caucasian population CF is the most common autosomal recessive disease, which happens for 1 person in 3,500 births [1]. In the course of CF, there is a dysfunction of many organs, mainly the respiratory and digestive systems. Symptomatic treatment of cystic fibrosis is very important. The change in daily eating habits, the use of proper breathing techniques and psychotherapy also have an impact on improving the quality of life of patients. In the past patients died at a young age. The progress in the diagnosis and treatment of cystic fibrosis has meant that nowadays more and more people are reaching adulthood. In recent years, the median survival of patients has increased to 46.2 years. [2] Purpose The aim of this review is to present the current state of knowledge about ways to improve the quality and length of life of patients with CF. Methods The literature available in the Pubmed and Google Scholarship databases was reviewed using key phrases. Results Additional methods of treatment, such as: learning the correct breathing technique, oxygen therapy, physical exercise or proper nutrition, significantly improve the living conditions of patients.

This paper presents the results of aerodynamic testing of air-launch rocket kit models for launching payloads into a low Earth orbit. The work was performed in a low-speed wind tunnel at the Military University of Technology (MUT, Warsaw, Poland)), using symmetrical airflow. Two carrier aircraft models were tested, i.e., Su-22 and MiG-29 aircraft without launched payloads and with these payloads at a dynamic pressure of q = 500 [Pa] and the range of angles of attack at α = -2828. The values obtained related to the aerodynamic drag coefficient, aerodynamic lift coefficient, pitching moment coefficient and lift to drag ratio, and are given in tabular and graphic forms. The tests were primarily used to validate the numerical results obtained during implementation of the project “Air-assisted rocket system for launching payloads into low Earth orbit - feasibility study”.

Depression is a common mental health disorder that affects the majority of the population. The exact cause of depression is not fully understood, but various factors such as genetics, environmental stressors, and psychological factors are believed to play a role. Due to the complexity of the etiopathogenesis of depression, the selection of appropriate therapeutic management is sometimes complicated. Treatment for depression typically involves a combination of medication and psychotherapy. Antidepressant medication can help alleviate symptoms by regulating neurotransmitters in the brain, while psychotherapy can help individuals understand and change negative thoughts and behaviors. Physical activity, such as sport, has been shown to have a positive impact on mental health and can help alleviate symptoms of depression. Exercise releases endorphins, reducing stress and improving mood. Health education can also play a role in preventing and managing depression by raising awareness, reducing stigma, and teaching individuals coping skills to maintain good mental health.

Objective The aim of the study was to indicate the difficulties associated with gluten-free diet and the point of its use by people without medical indications. Another important aspect of the article was to analyze the impact of this diet on the course of chronic diseases. Methods For the purposes of writing this article, the available literature was reviewed. Using keywords such as gluten, gluten-free, or diet, the database of medical publications - PubMed was searched. Results: The popularity of the gluten-free diet is growing. The reason for this is increased interest in health lifestyle and nutrition as well as the influence of the mass media. Because of that, the number of people on a gluten-free diet without medical indications is increasing. Following a gluten-free diet is associated with many difficulties. Gluten-free products are much more expensive and less available than their gluten-containing counterparts. It is associated with many obstacles in everyday life. An important aspect is also the imbalance of supplied nutrients and the risk of macro and micronutrient deficiencies, such as magnesium, zinc or selenium, as a result of the gluten-free diet. With the increasing popularity of the gluten-free diet, there are more and more studies on the potential benefits of its use in chronic diseases. Conclusion: A gluten-free diet remains the only therapeutic option in the course of diseases such as celiac disease, non-celiac gluten sensitivity or wheat allergy. Due to the insufficient amount of data, its use is not recommended in the course of other chronic diseases and in the population of people without medical indications.

Introduction: Treatment of breast cancer may be associated with the subsequent occurrence of many side effects, which may have a significant negative impact on the quality of life of patients after treatment. Such patients may experience bothersome menopausal symptoms, persistent pain, insomnia and depressed mood. The most common treatment to combat the above symptoms is pharmacotherapy, which in turn could also be associated with additional side effects. Cognitive-behavioral therapy can be an effective alternative to pharmacological treatment as well as an effective complementary treatment. Aim of the study: The aim of the study is to summarize the current state of knowledge on the impact of cognitive-behavioral therapy on improving quality of life of patients after breast cancer treatment. Material and methods: The literature available in the Pubmed database was reviewed using key phrases. Results: Cognitive-behavioral therapy used in patients after breast cancer treatment brings good results in combating symptoms such as anxiety, depression, menopausal symptoms, persistent, chronic pain or insomnia resulting from the above symptoms. With the above therapy, you can correct not only the severity, but above all the perception of all of the above-mentioned symptoms, which is of key importance in the context of maintaining the quality of life as before the start of treatment. Conclusion: The development of patient education on the benefits of using cognitive behavioral therapy as an adjuvant treatment after breast cancer treatment may have a beneficial effect on improving the quality of life in these patients.

Introduction Acne vulgaris is the most common skin disease that affects the majority of the population. Concepts on the pathogenesis of this disease have been changing over the years, as evidenced by the current indication of the precedence of inflammatory or immunological processes over disorders of keratinization of the outlets of hair and sebaceous units during the formation of acne lesions. Due to the complexity of the etiopathogenesis of acne vulgaris, the selection of appropriate therapeutic management is sometimes complicated. In addition, the process of treating the disease is multifaceted and time-consuming. Purpose The purpose of this review is to present the current state of knowledge on the effects of physical activity, diet and stress on acne vulgaris, as well as on the pathogenesis of acne vulgaris and the therapeutic management of patients suffering from this disease. Methods Literature was searched in PubMed and Google Scholarship databases. Publicly available books were searched. Results There is a proven precedence of inflammatory or immune processes over disorders of the keratinization of the estuaries of hair and sebaceous units during the formation of acne lesions. Conclusions Specialists should delve into the mechanism of the problem visible on the patient's skin to effectively and permanently cure the disease.