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1. First Dark Matter Search Results from the LUX-ZEPLIN (LZ) Experiment

Author: Aalbers, J., Akerib, D. S., Akerlof, C. W., Musalhi, A. K. Al, Alder, F., Alqahtani, A., Alsum, S. K., Amarasinghe, C. S., Ames, A., Anderson, T. J., Angelides, N., Araújo, H. M., Armstrong, J. E., Arthurs, M., Azadi, S., Bailey, A. J., Baker, A., Balajthy, J., Balashov, S., Bang, J., Bargemann, J. W., Barry, M. J., Barthel, J., Bauer, D., Baxter, A., Beattie, K., Belle, J., Beltrame, P., Bensinger, J., Benson, T., Bernard, E. P., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Birrittella, B., Blockinger, G. M., Boast, K. E., Boxer, B., Bramante, R., Brew, C. A. J., Brás, P., Buckley, J. H., Bugaev, V. V., Burdin, S., Busenitz, J. K., Buuck, M., Cabrita, R., Carels, C., Carlsmith, D. L., Carlson, B., Carmona-Benitez, M. C., Cascella, M., Chan, C., Chawla, A., Chen, H., Cherwinka, J. J., Chott, N. I., Cole, A., Coleman, J., Converse, M. V., Cottle, A., Cox, G., Craddock, W. W., Creaner, O., Curran, D., Currie, A., Cutter, J. E., Dahl, C. E., David, A., Davis, J., Davison, T. J. R., Delgaudio, J., Dey, S., de Viveiros, L., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Dushkin, A., Edberg, T. K., Edwards, W. R., Elnimr, M. M., Emmet, W. T., Eriksen, S. R., Faham, C. H., Fan, A., Fayer, S., Fearon, N. M., Fiorucci, S., Flaecher, H., Ford, P., Francis, V. B., Fraser, E. D., Fruth, T., Gaitskell, R. J., Gantos, N. J., Garcia, D., Geffre, A., Gehman, V. M., Genovesi, J., Ghag, C., Gibbons, R., Gibson, E., Gilchriese, M. G. D., Gokhale, S., Gomber, B., Green, J., Greenall, A., Greenwood, S., van der Grinten, M. G. D., Gwilliam, C. B., Hall, C. R., Hans, S., Hanzel, K., Harrison, A., Hartigan-O'Connor, E., Haselschwardt, S. J., Hertel, S. A., Heuermann, G., Hjemfelt, C., Hoff, M. D., Holtom, E., Hor, J. Y-K., Horn, M., Huang, D. Q., Hunt, D., Ignarra, C. M., Jacobsen, R. G., Jahangir, O., James, R. S., Jeffery, S. N., Ji, W., Johnson, J., Kaboth, A. C., Kamaha, A. C., Kamdin, K., Kasey, V., Kazkaz, K., Keefner, J., Khaitan, D., Khaleeq, M., Khazov, A., Khurana, I., Kim, Y. D., Kocher, C. D., Kodroff, D., Korley, L., Korolkova, E. V., Kras, J., Kraus, H., Kravitz, S., Krebs, H. J., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Kyre, S., Landerud, B., Leason, E. A., Lee, C., Lee, J., Leonard, D. S., Leonard, R., Lesko, K. T., Levy, C., Li, J., Liao, F. -T., Liao, J., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Liu, R., Liu, X., Liu, Y., Loniewski, C., Lopes, M. I., Asamar, E. Lopez, Paredes, B. López, Lorenzon, W., Lucero, D., Luitz, S., Lyle, J. M., Majewski, P. A., Makkinje, J., Malling, D. C., Manalaysay, A., Manenti, L., Mannino, R. L., Marangou, N., Marzioni, M. F., Maupin, C., McCarthy, M. E., McConnell, C. T., McKinsey, D. N., McLaughlin, J., Meng, Y., Migneault, J., Miller, E. H., Mizrachi, E., Mock, J. A., Monte, A., Monzani, M. E., Morad, J. A., Mendoza, J. D. Morales, Morrison, E., Mount, B. J., Murdy, M., Murphy, A. St. J., Naim, D., Naylor, A., Nedlik, C., Nehrkorn, C., Neves, F., Nguyen, A., Nikoleyczik, J. A., Nilima, A., O'Dell, J., O'Neill, F. G., O'Sullivan, K., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Orpwood, J., Pagenkopf, D., Pal, S., Palladino, K. J., Palmer, J., Pangilinan, M., Parveen, N., Patton, S. J., Pease, E. K., Penning, B., Pereira, C., Pereira, G., Perry, E., Pershing, T., Peterson, I. B., Piepke, A., Podczerwinski, J., Porzio, D., Powell, S., Preece, R. M., Pushkin, K., Qie, Y., Ratcliff, B. N., Reichenbacher, J., Reichhart, L., Rhyne, C. A., Richards, A., Riffard, Q., Rischbieter, G. R. C., Rodrigues, J. P., Rodriguez, A., Rose, H. J., Rosero, R., Rossiter, P., Rushton, T., Rutherford, G., Rynders, D., Saba, J. S., Santone, D., Sazzad, A. B. M. R., Schnee, R. W., Scovell, P. R., Seymour, D., Shaw, S., Shutt, T., Silk, J. J., Silva, C., Sinev, G., Skarpaas, K., Skulski, W., Smith, R., Solmaz, M., Solovov, V. N., Sorensen, P., Soria, J., Stancu, I., Stark, M. R., Stevens, A., Stiegler, T. M., Stifter, K., Studley, R., Suerfu, B., Sumner, T. J., Sutcliffe, P., Swanson, N., Szydagis, M., Tan, M., Taylor, D. J., Taylor, R., Taylor, W. C., Temples, D. J., Tennyson, B. P., Terman, P. A., Thomas, K. J., Tiedt, D. R., Timalsina, M., To, W. H., Tomás, A., Tong, Z., Tovey, D. R., Tranter, J., Trask, M., Tripathi, M., Tronstad, D. R., Tull, C. E., Turner, W., Tvrznikova, L., Utku, U., Va'vra, J., Vacheret, A., Vaitkus, A. C., Verbus, J. R., Voirin, E., Waldron, W. L., Wang, A., Wang, B., Wang, J. J., Wang, W., Wang, Y., Watson, J. R., Webb, R. C., White, A., White, D. T., White, J. T., White, R. G., Whitis, T. J., Williams, M., Wisniewski, W. J., Witherell, M. S., Wolfs, F. L. H., Wolfs, J. D., Woodford, S., Woodward, D., Worm, S. D., Wright, C. J., Xia, Q., Xiang, X., Xiao, Q., Xu, J., Yeh, M., Yin, J., Young, I., Zarzhitsky, P., Zuckerman, A., and Zweig, E. A.
Subjects: High Energy Physics - Experiment, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: The LUX-ZEPLIN experiment is a dark matter detector centered on a dual-phase xenon time projection chamber operating at the Sanford Underground Research Facility in Lead, South Dakota, USA. This Letter reports results from LUX-ZEPLIN's first search for weakly interacting massive particles (WIMPs) with an exposure of 60~live days using a fiducial mass of 5.5 t. A profile-likelihood ratio analysis shows the data to be consistent with a background-only hypothesis, setting new limits on spin-independent WIMP-nucleon, spin-dependent WIMP-neutron, and spin-dependent WIMP-proton cross sections for WIMP masses above 9 GeV/c$^2$. The most stringent limit is set for spin-independent scattering at 36 GeV/c$^2$, rejecting cross sections above 9.2$\times 10^{-48}$ cm$^2$ at the 90% confidence level., Comment: 9 pages, 8 figures. See https://doi.org/10.1103/PhysRevLett.131.041002 for a data release related to this paper
Published: 2022
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2. A Computing and Detector Simulation Framework for the HIBEAM/NNBAR Experimental Program at the ESS

Author: Barrow, J., Brooijmans, G., Damian, J. I. M., DiJulio, D., Dunne, K., Frost, M., Golubeva, E., Kamyshkov, Y., Kittelmann, T., Klinkby, E., Kókai, Z., Makkinje, J., Meirose, B., Milstead, D., Nepomuceno, A., Oskarsson, A., Ramic, K., Rizzi, N., Santoro, V., Silverstein, S., Takibayev, A., Wagner, R., Yiu, S-C., Zanini, L., and Zimmer, O.
Subjects: Physics - Instrumentation and Detectors
Abstract: The HIBEAM/NNBAR program is a proposed two-stage experiment at the European Spallation Source focusing on searches for baryon number violation via processes in which neutrons convert to antineutrons. This paper outlines the computing and detector simulation framework for the HIBEAM/NNBAR program. The simulation is based on predictions of neutron flux and neutronics together with signal and background generation. A range of diverse simulation packages are incorporated, including Monte Carlo transport codes, neutron ray-tracing simulation packages, and detector simulation software. The common simulation package in which these elements are interfaced together is discussed. Data management plans and triggers are also described., Comment: Contribution to CHEP2021. Accepted for publication in the European Physical Journal (EPJ) Web of Conferences
Published: 2021
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3. New high-sensitivity searches for neutrons converting into antineutrons and/or sterile neutrons at the European Spallation Source

Author: Addazi, A., Anderson, K., Ansell, S., Babu, K., Barrow, J., Baxter, D. V., Bentley, P. M., Berezhiani, Z., Bevilacqua, R., Bohm, C., Brooijmans, G., Broussard, J., Biondi, R., Dev, B., Crawford, C., Dolgov, A., Dunne, K., Fierlinger, P., Fitzsimmons, M. R., Fomin, A., Frost, M., Gardner, S., Galindo-Uribarri, A., Golubeva, E., Girmohanta, S., Greene, G. L., Greenshaw, T., Gudkov, V., Hall-Wilton, R., Heilbronn, L., Herrero-Garcia, J., Ito, G. Ichikawa T. M., Iverson, E., Johansson, T., Joensson, L., Jwa, Y-J., Kamyshkov, Y., Kanaki, K., Kearns, E., Kitaguchi, M., Kittelmann, T., Klinkby, E., Koerner, L. W., Kopeliovich, B., Kozela, A., Kudryatsev, V., Kupsc, A., Lee, Y., Lindroos, M., Makkinje, J., Marquez, J. I., Mohapatra, R., Meirose, B., Miller, T. M., Milstead, D., Morishima, T., Muhrer, G., Mumm, H. P., Nagamoto, K., Nesvizhevsky, V. V., Nilsson, T., Oskarsson, A., Paryev, E., Pattie Jr, R. W., Penttil, S., Pokotilovski, Y. N., Potashnikova, I., Redding, C., Richard, J-M, Ries, D., Rinaldi, E., Ruggles, A., Rybolt, B., Santoro, V., Sarkar, U., Saunders, A., Senjanovic, G., Serebrov, A. P., Shimizu, H. M., Shrock, R., Silverstein, S., Silvermyr, D., Snow, W. M., Takibayev, A., Townsend, L., Tkachev, I., Varriano, L., Vainshtein, A., de VRies, J., Woracek, R., Yamagata, Y., Young, A. R., Zanini, L., Zhang, Z., and Zimmer, O.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: The violation of Baryon Number, $\mathcal{B}$, is an essential ingredient for the preferential creation of matter over antimatter needed to account for the observed baryon asymmetry in the universe. However, such a process has yet to be experimentally observed. The HIBEAM/NNBAR %experiment program is a proposed two-stage experiment at the European Spallation Source (ESS) to search for baryon number violation. The program will include high-sensitivity searches for processes that violate baryon number by one or two units: free neutron-antineutron oscillation ($n\rightarrow \bar{n}$) via mixing, neutron-antineutron oscillation via regeneration from a sterile neutron state ($n\rightarrow [n',\bar{n}'] \rightarrow \bar{n}$), and neutron disappearance ($n\rightarrow n'$); the effective $\Delta \mathcal{B}=0$ process of neutron regeneration ($n\rightarrow [n',\bar{n}'] \rightarrow n$) is also possible. The program can be used to discover and characterise mixing in the neutron, antineutron, and sterile neutron sectors. The experiment addresses topical open questions such as the origins of baryogenesis, the nature of dark matter, and is sensitive to scales of new physics substantially in excess of those available at colliders. A goal of the program is to open a discovery window to neutron conversion probabilities (sensitivities) by up to three orders of magnitude compared with previous searches. The opportunity to make such a leap in sensitivity tests should not be squandered. The experiment pulls together a diverse international team of physicists from the particle (collider and low energy) and nuclear physics communities, while also including specialists in neutronics and magnetics.
Published: 2020
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4. The LUX-ZEPLIN (LZ) radioactivity and cleanliness control programs

Author: Akerib, D. S., Akerlof, C. W., Akimov, D. Yu., Alquahtani, A., Alsum, S. K., Anderson, T. J., Angelides, N., Araújo, H. M., Arbuckle, A., Armstrong, J. E., Arthurs, M., Auyeung, H., Aviles, S., Bai, X., Bailey, A. J., Balajthy, J., Balashov, S., Bang, J., Barry, M. J., Bauer, D., Bauer, P., Baxter, A., Belle, J., Beltrame, P., Bensinger, J., Benson, T., Bernard, E. P., Bernstein, A., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Birrittella, B., Boast, K. E., Bolozdynya, A. I., Boulton, E. M., Boxer, B., Bramante, R., Branson, S., Brás, P., Breidenbach, M., Brew, C. A. J., Buckley, J. H., Bugaev, V. V., Bunker, R., Burdin, S., Busenitz, J. K., Cabrita, R., Campbell, J. S., Carels, C., Carlsmith, D. L., Carlson, B., Carmona-Benitez, M. C., Cascella, M., Chan, C., Cherwinka, J. J., Chiller, A. A., Chiller, C., Chott, N. I., Cole, A., Coleman, J., Colling, D., Conley, R. A., Cottle, A., Coughlen, R., Cox, G., Craddock, W. W., Curran, D., Currie, A., Cutter, J. E., da Cunhaw, J. P., Dahl, C. E., Dardin, S., Dasu, S., Davis, J., Davison, T. J. R., de Viveiros, L., Decheine, N., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Dushkin, A., Edberg, T. K., Edwards, W. R., Edwards, B. N., Edwards, J., Elnimr, M. M., Emmet, W. T., Eriksen, S. R., Faham, C. H., Fan, A., Fayer, S., Fiorucci, S., Flaecher, H., Florang, I. M. Fogarty, Ford, P., Francis, V. B., Fraser, E. D., Froborg, F., Fruth, T., Gaitskell, R. J., Gantos, N. J., Garcia, D., Gehman, V. M., Gelfand, R., Genovesi, J., Gerhard, R. M., Ghag, C., Gibson, E., Gilchriese, M. G. D., Gokhale, S., Gomber, B., Gonda, T. G., Greenall, A., Greenwood, S., Gregerson, G., van der Grinten, M. G. D., Gwilliam, C. B., Hall, C. R., Hamilton, D., Hans, S., Hanzel, K., Harrington, T., Harrison, A., Harrison, J., Hasselkus, C., Haselschwardt, S. J., Hemer, D., Hertel, S. A., Heise, J., Hillbrand, S., Hitchcock, O., Hjemfelt, C., Hoff, M. D., Holbrook, B., Holtom, E., Hor, J. Y-K., Horn, M., Huang, D. Q., Hurteau, T. W., Ignarra, C. M., Irving, M. N., Jacobsen, R. G., Jahangir, O., Jeffery, S. N., Ji, W., Johnson, M., Johnson, J., Johnson, P., Jones, W. G., Kaboth, A. C., Kamaha, A., Kamdin, K., Kasey, V., Kazkaz, K., Keefner, J., Khaitan, D., Khaleeq, M., Khazov, A., Khromov, A. V., Khurana, I., Kim, Y. D., Kim, W. T., Kocher, C. D., Kodroff, D., Konovalov, A. M., Korley, L., Korolkova, E. V., Koyuncu, M., Kras, J., Kraus, H., Kravitz, S. W., Krebs, H. J., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Kumpan, A. V., Kyre, S., Lambert, A. R., Landerud, B., Larsen, N. A., Laundrie, A., Leason, E. A., Lee, H. S., Lee, J., Lee, C., Lenardo, B. G., Leonard, D. S., Leonard, R., Lesko, K. T., Levy, C., Li, J., Liu, Y., Liao, J., Liao, F. -T., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Liu, R., Liu, X., Loniewski, C., Lopes, M. I., Lopez-Asamar, E., Paredes, B. López, Lorenzon, W., Lucero, D., Luitz, S., Lyle, J. M., Lynch, C., Majewski, P. A., Makkinje, J., Malling, D. C., Manalaysay, A., Manenti, L., Mannino, R. L., Marangou, N., Markley, D. J., MarrLaundrie, P., Martin, T. J., Marzioni, M. F., Maupin, C., McConnell, C. T., McKinsey, D. N., McLaughlin, J., Mei, D. -M., Meng, Y., Miller, E. H., Minaker, Z. J., Mizrachi, E., Mock, J., Molash, D., Monte, A., Monzani, M. E., Morad, J. A., Morrison, E., Mount, B. J., Murphy, A. St. J., Naim, D., Naylor, A., Nedlik, C., Nehrkorn, C., Nelson, H. N., Nesbit, J., Neves, F., Nikkel, J. A., Nikoleyczik, J. A., Nilima, A., O'Dell, J., Oh, H., O'Neill, F. G., O'Sullivan, K., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Oxborough, L., Pagac, A., Pagenkopf, D., Pal, S., Palladino, K. J., Palmaccio, V. M., Palmer, J., Pangilinan, M., Parveen, N., Patton, S. J., Pease, E. K., Penning, B. P., Pereira, G., Pereira, C., Peterson, I. B., Piepke, A., Pierson, S., Powell, S., Preece, R. M., Pushkin, K., Qie, Y., Racine, M., Ratcliff, B. N., Reichenbacher, J., Reichhart, L., Rhyne, C. A., Richards, A., Riffard, Q., Rischbieter, G. R. C., Rodrigues, J. P., Rose, H. J., Rosero, R., Rossiter, P., Rucinski, R., Rutherford, G., Saba, J. S., Sabarots, L., Santone, D., Sarychev, M., Sazzad, A. B. M. R., Schnee, R. W., Schubnell, M., Scovell, P. R., Severson, M., Seymour, D., Shaw, S., Shutt, G. W., Shutt, T. A., Silk, J. J., Silva, C., Skarpaas, K., Skulski, W., Smith, A. R., Smith, R. J., Smith, R. E., So, J., Solmaz, M., Solovov, V. N., Sorensen, P., Sosnovtsev, V. V., Stancu, I., Stark, M. R., Stephenson, S., Stern, N., Stevens, A., Stiegler, T. M., Stifter, K., Studley, R., Sumner, T. J., Sundarnath, K., Sutcliffe, P., Swanson, N., Szydagis, M., Tan, M., Taylor, W. C., Taylor, R., Taylor, D. J., Temples, D., Tennyson, B. P., Terman, P. A., Thomas, K. J., Thomson, J. A., Tiedt, D. R., Timalsina, M., To, W. H., Tomás, A., Tope, T. E., Tripathi, M., Tronstad, D. R., Tull, C. E., Turner, W., Tvrznikova, L., Utes, M., Utku, U., Uvarov, S., Va'vra, J., Vacheret, A., Vaitkus, A., Verbus, J. R., Vietanen, T., Voirin, E., Vuosalo, C. O., Walcott, S., Waldron, W. L., Walker, K., Wang, J. J., Wang, R., Wang, L., Wang, W., Wang, Y., Watson, J. R., Migneault, J., Weatherly, S., Webb, R. C., Wei, W. -Z., While, M., White, R. G., White, J. T., White, D. T., Whitis, T. J., Wisniewski, W. J., Wilson, K., Witherell, M. S., Wolfs, F. L. H., Wolfs, J. D., Woodward, D., Worm, S. D., Xiang, X., Xiao, Q., Xu, J., Yeh, M., Yin, J., Young, I., Zhang, C., and Zarzhitsky, P.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: LUX-ZEPLIN (LZ) is a second-generation direct dark matter experiment with spin-independent WIMP-nucleon scattering sensitivity above $1.4 \times 10^{-48}$ cm$^{2}$ for a WIMP mass of 40 GeV/c$^{2}$ and a 1000 d exposure. LZ achieves this sensitivity through a combination of a large 5.6 t fiducial volume, active inner and outer veto systems, and radio-pure construction using materials with inherently low radioactivity content. The LZ collaboration performed an extensive radioassay campaign over a period of six years to inform material selection for construction and provide an input to the experimental background model against which any possible signal excess may be evaluated. The campaign and its results are described in this paper. We present assays of dust and radon daughters depositing on the surface of components as well as cleanliness controls necessary to maintain background expectations through detector construction and assembly. Finally, examples from the campaign to highlight fixed contaminant radioassays for the LZ photomultiplier tubes, quality control and quality assurance procedures through fabrication, radon emanation measurements of major sub-systems, and bespoke detector systems to assay scintillator are presented., Comment: 45 pages (79 inc. tables), 7 figures, 9 tables
Published: 2020
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5. Rebalancing of mitochondrial homeostasis through an NAD+-SIRT1 pathway preserves intestinal barrier function in severe malnutrition

Author: Ling, Catriona, Versloot, Christian J., Arvidsson Kvissberg, Matilda E., Hu, Guanlan, Swain, Nathan, Horcas-Nieto, José M., Miraglia, Emily, Thind, Mehakpreet K., Farooqui, Amber, Gerding, Albert, van Eunen, Karen, Koster, Mirjam H., Kloosterhuis, Niels J., Chi, Lijun, ChenMi, YueYing, Langelaar-Makkinje, Miriam, Bourdon, Celine, Swann, Jonathan, Smit, Marieke, de Bruin, Alain, Youssef, Sameh A., Feenstra, Marjon, van Dijk, Theo H., Thedieck, Kathrin, Jonker, Johan W., Kim, Peter K., Bakker, Barbara M., and Bandsma, Robert H.J.
Published: 2023
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6. Rebalancing of mitochondrial homeostasis through an NAD+-SIRT1 pathway preserves intestinal barrier function in severe malnutritionResearch in context

Author: Catriona Ling, Christian J. Versloot, Matilda E. Arvidsson Kvissberg, Guanlan Hu, Nathan Swain, José M. Horcas-Nieto, Emily Miraglia, Mehakpreet K. Thind, Amber Farooqui, Albert Gerding, Karen van Eunen, Mirjam H. Koster, Niels J. Kloosterhuis, Lijun Chi, YueYing ChenMi, Miriam Langelaar-Makkinje, Celine Bourdon, Jonathan Swann, Marieke Smit, Alain de Bruin, Sameh A. Youssef, Marjon Feenstra, Theo H. van Dijk, Kathrin Thedieck, Johan W. Jonker, Peter K. Kim, Barbara M. Bakker, and Robert H.J. Bandsma
Subjects: Malnutrition, Enteropathy, SIRT1, Autophagy, Mitochondria, Medicine, Medicine (General), R5-920
Abstract: Summary: Background: The intestine of children with severe malnutrition (SM) shows structural and functional changes that are linked to increased infection and mortality. SM dysregulates the tryptophan-kynurenine pathway, which may impact processes such as SIRT1- and mTORC1-mediated autophagy and mitochondrial homeostasis. Using a mouse and organoid model of SM, we studied the repercussions of these dysregulations on malnutrition enteropathy and the protective capacity of maintaining autophagy activity and mitochondrial health. Methods: SM was induced through feeding male weanling C57BL/6 mice a low protein diet (LPD) for 14-days. Mice were either treated with the NAD+-precursor, nicotinamide; an mTORC1-inhibitor, rapamycin; a SIRT1-activator, resveratrol; or SIRT1-inhibitor, EX-527. Malnutrition enteropathy was induced in enteric organoids through amino-acid deprivation. Features of and pathways to malnutrition enteropathy were examined, including paracellular permeability, nutrient absorption, and autophagic, mitochondrial, and reactive-oxygen-species (ROS) abnormalities. Findings: LPD-feeding and ensuing low-tryptophan availability led to villus atrophy, nutrient malabsorption, and intestinal barrier dysfunction. In LPD-fed mice, nicotinamide-supplementation was linked to SIRT1-mediated activation of mitophagy, which reduced damaged mitochondria, and improved intestinal barrier function. Inhibition of mTORC1 reduced intestinal barrier dysfunction and nutrient malabsorption. Findings were validated and extended using an organoid model, demonstrating that resolution of mitochondrial ROS resolved barrier dysfunction. Interpretation: Malnutrition enteropathy arises from a dysregulation of the SIRT1 and mTORC1 pathways, leading to disrupted autophagy, mitochondrial homeostasis, and ROS. Whether nicotinamide-supplementation in children with SM could ameliorate malnutrition enteropathy should be explored in clinical trials. Funding: This work was supported by the Bill and Melinda Gates Foundation, the Sickkids Research Institute, the Canadian Institutes of Health Research, and the University Medical Center Groningen.
Published: 2023
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7. The LUX-ZEPLIN (LZ) Experiment

Author: The LZ Collaboration, Akerib, D. S., Akerlof, C. W., Akimov, D. Yu., Alquahtani, A., Alsum, S. K., Anderson, T. J., Angelides, N., Araújo, H. M., Arbuckle, A., Armstrong, J. E., Arthurs, M., Auyeung, H., Bai, X., Bailey, A. J., Balajthy, J., Balashov, S., Bang, J., Barry, M. J., Barthel, J., Bauer, D., Bauer, P., Baxter, A., Belle, J., Beltrame, P., Bensinger, J., Benson, T., Bernard, E. P., Bernstein, A., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birrittella, B., Boast, K. E., Bolozdynya, A. I., Boulton, E. M., Boxer, B., Bramante, R., Branson, S., Brás, P., Breidenbach, M., Buckley, J. H., Bugaev, V. V., Bunker, R., Burdin, S., Busenitz, J. K., Campbell, J. S., Carels, C., Carlsmith, D. L., Carlson, B., Carmona-Benitez, M. C., Cascella, M., Chan, C., Cherwinka, J. J., Chiller, A. A., Chiller, C., Chott, N. I., Cole, A., Coleman, J., Colling, D., Conley, R. A., Cottle, A., Coughlen, R., Craddock, W. W., Curran, D., Currie, A., Cutter, J. E., da Cunha, J. P., Dahl, C. E., Dardin, S., Dasu, S., Davis, J., Davison, T. J. R., de Viveiros, L., Decheine, N., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Dushkin, A., Edberg, T. K., Edwards, W. R., Edwards, B. N., Edwards, J., Elnimr, M. M., Emmet, W. T., Eriksen, S. R., Faham, C. H., Fan, A., Fayer, S., Fiorucci, S., Flaecher, H., Florang, I. M. Fogarty, Ford, P., Francis, V. B., Froborg, F., Fruth, T., Gaitskell, R. J., Gantos, N. J., Garcia, D., Geffre, A., Gehman, V. M., Gelfand, R., Genovesi, J., Gerhard, R. M., Ghag, C., Gibson, E., Gilchriese, M. G. D., Gokhale, S., Gomber, B., Gonda, T. G., Greenall, A., Greenwood, S., Gregerson, G., van der Grinten, M. G. D., Gwilliam, C. B., Hall, C. R., Hamilton, D., Hans, S., Hanzel, K., Harrington, T., Harrison, A., Hasselkus, C., Haselschwardt, S. J., Hemer, D., Hertel, S. A., Heise, J., Hillbrand, S., Hitchcock, O., Hjemfelt, C., Hoff, M. D., Holbrook, B., Holtom, E., Hor, J. Y-K., Horn, M., Huang, D. Q., Hurteau, T. W., Ignarra, C. M., Irving, M. N., Jacobsen, R. G., Jahangir, O., Jeffery, S. N., Ji, W., Johnson, M., Johnson, J., Johnson, P., Jones, W. G., Kaboth, A. C., Kamaha, A., Kamdin, K., Kasey, V., Kazkaz, K., Keefner, J., Khaitan, D., Khaleeq, M., Khazov, A., Khromov, A. V., Khurana, I., Kim, Y. D., Kim, W. T., Kocher, C. D., Konovalov, A. M., Korley, L., Korolkova, E. V., Koyuncu, M., Kras, J., Kraus, H., Kravitz, S. W., Krebs, H. J., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Kumpan, A. V., Kyre, S., Lambert, A. R., Landerud, B., Larsen, N. A., Laundrie, A., Leason, E. A., Lee, H. S., Lee, J., Lee, C., Lenardo, B. G., Leonard, D. S., Leonard, R., Lesko, K. T., Levy, C., Li, J., Liu, Y., Liao, J., Liao, F. -T., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Liu, R., Liu, X., Loniewski, C., Lopes, M. I., Paredes, B. López, Lorenzon, W., Lucero, D., Luitz, S., Lyle, J. M., Lynch, C., Majewski, P. A., Makkinje, J., Malling, D. C., Manalaysay, A., Manenti, L., Mannino, R. L., Marangou, N., Markley, D. J., MarrLaundrie, P., Martin, T. J., Marzioni, M. F., Maupin, C., McConnell, C. T., McKinsey, D. N., McLaughlin, J., Mei, D. -M., Meng, Y., Miller, E. H., Minaker, Z. J., Mizrachi, E., Mock, J., Molash, D., Monte, A., Monzani, M. E., Morad, J. A., Morrison, E., Mount, B. J., Murphy, A. St. J., Naim, D., Naylor, A., Nedlik, C., Nehrkorn, C., Nelson, H. N., Nesbit, J., Neves, F., Nikkel, J. A., Nikoleyczik, J. A., Nilima, A., O'Dell, J., Oh, H., O'Neill, F. G., O'Sullivan, K., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Oxborough, L., Pagac, A., Pagenkopf, D., Pal, S., Palladino, K. J., Palmaccio, V. M., Palmer, J., Pangilinan, M., Patton, S. J., Pease, E. K., Penning, B. P., Pereira, G., Pereira, C., Peterson, I. B., Piepke, A., Pierson, S., Powell, S., Preece, R. M., Pushkin, K., Qie, Y., Racine, M., Ratcliff, B. N., Reichenbacher, J., Reichhart, L., Rhyne, C. A., Richards, A., Riffard, Q., Rischbieter, G. R. C., Rodrigues, J. P., Rose, H. J., Rosero, R., Rossiter, P., Rucinski, R., Rutherford, G., Rynders, D., Saba, J. S., Sabarots, L., Santone, D., Sarychev, M., Sazzad, A. B. M. R., Schnee, R. W., Schubnell, M., Scovell, P. R., Severson, M., Seymour, D., Shaw, S., Shutt, G. W., Shutt, T. A., Silk, J. J., Silva, C., Skarpaas, K., Skulski, W., Smith, A. R., Smith, R. J., Smith, R. E., So, J., Solmaz, M., Solovov, V. N., Sorensen, P., Sosnovtsev, V. V., Stancu, I., Stark, M. R., Stephenson, S., Stern, N., Stevens, A., Stiegler, T. M., Stifter, K., Studley, R., Sumner, T. J., Sundarnath, K., Sutcliffe, P., Swanson, N., Szydagis, M., Tan, M., Taylor, W. C., Taylor, R., Taylor, D. J., Temples, D., Tennyson, B. P., Terman, P. A., Thomas, K. J., Thomson, J. A., Tiedt, D. R., Timalsina, M., To, W. H., Tomás, A., Tope, T. E., Tripathi, M., Tronstad, D. R., Tull, C. E., Turner, W., Tvrznikova, L., Utes, M., Utku, U., Uvarov, S., Va'vra, J., Vacheret, A., Vaitkus, A., Verbus, J. R., Vietanen, T., Voirin, E., Vuosalo, C. O., Walcott, S., Waldron, W. L., Walker, K., Wang, J. J., Wang, R., Wang, L., Wang, Y., Watson, J. R., Migneault, J., Weatherly, S., Webb, R. C., Wei, W. -Z., While, M., White, R. G., White, J. T., White, D. T., Whitis, T. J., Wisniewski, W. J., Wilson, K., Witherell, M. S., Wolfs, F. L. H., Wolfs, J. D., Woodward, D., Worm, S. D., Xiang, X., Xiao, Q., Xu, J., Yeh, M., Yin, J., Young, I., and Zhang, C.
Subjects: Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract: We describe the design and assembly of the LUX-ZEPLIN experiment, a direct detection search for cosmic WIMP dark matter particles. The centerpiece of the experiment is a large liquid xenon time projection chamber sensitive to low energy nuclear recoils. Rejection of backgrounds is enhanced by a Xe skin veto detector and by a liquid scintillator Outer Detector loaded with gadolinium for efficient neutron capture and tagging. LZ is located in the Davis Cavern at the 4850' level of the Sanford Underground Research Facility in Lead, South Dakota, USA. We describe the major subsystems of the experiment and its key design features and requirements.
Published: 2019
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8. Organoids as a model to study intestinal and liver dysfunction in severe malnutrition

Author: Horcas-Nieto, José M., Versloot, Christian J., Langelaar-Makkinje, Miriam, Gerding, Albert, Blokzijl, Tjasso, Koster, Mirjam H., Baanstra, Mirjam, Martini, Ingrid A., Coppes, Robert P., Bourdon, Céline, van Ijzendoorn, Sven C.D., Kim, Peter, Bandsma, Robert H.J., and Bakker, Barbara M.
Published: 2023
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9. T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice

Author: Venetia Bazioti, Anouk M. La Rose, Sjors Maassen, Frans Bianchi, Rinse de Boer, Benedek Halmos, Deepti Dabral, Emma Guilbaud, Arthur Flohr-Svendsen, Anouk G. Groenen, Alejandro Marmolejo-Garza, Mirjam H. Koster, Niels J. Kloosterhuis, Rick Havinga, Alle T. Pranger, Miriam Langelaar-Makkinje, Alain de Bruin, Bart van de Sluis, Alison B. Kohan, Laurent Yvan-Charvet, Geert van den Bogaart, and Marit Westerterp
Subjects: Science
Abstract: Cholesterol efflux is mediated by specific transporters in T cells. Here the authors show that when the ABCA1/ABCG1 cholesterol transporters are absent, peripheral T cell numbers are reduced but activation increased with a premature aging phenotype of T cell senescence and apoptosis in middle aged Ldlr −/− mice.
Published: 2022
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10. Butyrate oxidation attenuates the butyrate-induced improvement of insulin sensitivity in myotubes

Author: Rios-Morales, Melany, Vieira-Lara, Marcel A., Homan, Esther, Langelaar-Makkinje, Miriam, Gerding, Albert, Li, Zhuang, Huijkman, Nicolette, Rensen, Patrick C.N., Wolters, Justina C., Reijngoud, Dirk-Jan, and Bakker, Barbara M.
Published: 2022
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11. T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice

Author: Bazioti, Venetia, La Rose, Anouk M., Maassen, Sjors, Bianchi, Frans, de Boer, Rinse, Halmos, Benedek, Dabral, Deepti, Guilbaud, Emma, Flohr-Svendsen, Arthur, Groenen, Anouk G., Marmolejo-Garza, Alejandro, Koster, Mirjam H., Kloosterhuis, Niels J., Havinga, Rick, Pranger, Alle T., Langelaar-Makkinje, Miriam, de Bruin, Alain, van de Sluis, Bart, Kohan, Alison B., Yvan-Charvet, Laurent, van den Bogaart, Geert, and Westerterp, Marit
Published: 2022
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12. Erratum to: The LUX-ZEPLIN (LZ) radioactivity and cleanliness control programs

Author: D. S. Akerib, C. W. Akerlof, D. Yu. Akimov, A. Alquahtani, S. K. Alsum, T. J. Anderson, N. Angelides, H. M. Araújo, A. Arbuckle, J. E. Armstrong, M. Arthurs, H. Auyeung, S. Aviles, X. Bai, A. J. Bailey, J. Balajthy, S. Balashov, J. Bang, M. J. Barry, D. Bauer, P. Bauer, A. Baxter, J. Belle, P. Beltrame, J. Bensinger, T. Benson, E. P. Bernard, A. Bernstein, A. Bhatti, A. Biekert, T. P. Biesiadzinski, H. J. Birch, B. Birrittella, K. E. Boast, A. I. Bolozdynya, E. M. Boulton, B. Boxer, R. Bramante, S. Branson, P. Brás, M. Breidenbach, C. A. J. Brew, J. H. Buckley, V. V. Bugaev, R. Bunker, S. Burdin, J. K. Busenitz, R. Cabrita, J. S. Campbell, C. Carels, D. L. Carlsmith, B. Carlson, M. C. Carmona-Benitez, M. Cascella, C. Chan, J. J. Cherwinka, A. A. Chiller, C. Chiller, N. I. Chott, A. Cole, J. Coleman, D. Colling, R. A. Conley, A. Cottle, R. Coughlen, G. Cox, W. W. Craddock, D. Curran, A. Currie, J. E. Cutter, J. P. da Cunha, C. E. Dahl, S. Dardin, S. Dasu, J. Davis, T. J. R. Davison, L. de Viveiros, N. Decheine, A. Dobi, J. E. Y. Dobson, E. Druszkiewicz, A. Dushkin, T. K. Edberg, W. R. Edwards, B. N. Edwards, J. Edwards, M. M. Elnimr, W. T. Emmet, S. R. Eriksen, C. H. Faham, A. Fan, S. Fayer, S. Fiorucci, H. Flaecher, I. M. Fogarty Florang, P. Ford, V. B. Francis, E. D. Fraser, F. Froborg, T. Fruth, R. J. Gaitskell, N. J. Gantos, D. Garcia, V. M. Gehman, R. Gelfand, J. Genovesi, R. M. Gerhard, C. Ghag, E. Gibson, M. G. D. Gilchriese, S. Gokhale, B. Gomber, T. G. Gonda, A. Greenall, S. Greenwood, G. Gregerson, M. G. D. van der Grinten, C. B. Gwilliam, C. R. Hall, D. Hamilton, S. Hans, K. Hanzel, T. Harrington, A. Harrison, J. Harrison, C. Hasselkus, S. J. Haselschwardt, D. Hemer, S. A. Hertel, J. Heise, S. Hillbrand, O. Hitchcock, C. Hjemfelt, M. D. Hoff, B. Holbrook, E. Holtom, J. Y-K. Hor, M. Horn, D. Q. Huang, T. W. Hurteau, C. M. Ignarra, M. N. Irving, R. G. Jacobsen, O. Jahangir, S. N. Jeffery, W. Ji, M. Johnson, J. Johnson, P. Johnson, W. G. Jones, A. C. Kaboth, A. Kamaha, K. Kamdin, V. Kasey, K. Kazkaz, J. Keefner, D. Khaitan, M. Khaleeq, A. Khazov, A. V. Khromov, I. Khurana, Y. D. Kim, W. T. Kim, C. D. Kocher, D. Kodroff, A. M. Konovalov, L. Korley, E. V. Korolkova, M. Koyuncu, J. Kras, H. Kraus, S. W. Kravitz, H. J. Krebs, L. Kreczko, B. Krikler, V. A. Kudryavtsev, A. V. Kumpan, S. Kyre, A. R. Lambert, B. Landerud, N. A. Larsen, A. Laundrie, E. A. Leason, H. S. Lee, J. Lee, C. Lee, B. G. Lenardo, D. S. Leonard, R. Leonard, K. T. Lesko, C. Levy, J. Li, Y. Liu, J. Liao, F.-T. Liao, J. Lin, A. Lindote, R. Linehan, W. H. Lippincott, R. Liu, X. Liu, C. Loniewski, M. I. Lopes, E. Lopez-Asamar, B. López Paredes, W. Lorenzon, D. Lucero, S. Luitz, J. M. Lyle, C. Lynch, P. A. Majewski, J. Makkinje, D. C. Malling, A. Manalaysay, L. Manenti, R. L. Mannino, N. Marangou, D. J. Markley, P. MarrLaundrie, T. J. Martin, M. F. Marzioni, C. Maupin, C. T. McConnell, D. N. McKinsey, J. McLaughlin, D.-M. Mei, Y. Meng, E. H. Miller, Z. J. Minaker, E. Mizrachi, J. Mock, D. Molash, A. Monte, M. E. Monzani, J. A. Morad, E. Morrison, B. J. Mount, A. St. J. Murphy, D. Naim, A. Naylor, C. Nedlik, C. Nehrkorn, H. N. Nelson, J. Nesbit, F. Neves, J. A. Nikkel, J. A. Nikoleyczik, A. Nilima, J. O’Dell, H. Oh, F. G. O’Neill, K. O’Sullivan, I. Olcina, M. A. Olevitch, K. C. Oliver-Mallory, L. Oxborough, A. Pagac, D. Pagenkopf, S. Pal, K. J. Palladino, V. M. Palmaccio, J. Palmer, M. Pangilinan, N. Parveen, S. J. Patton, E. K. Pease, B. P. Penning, G. Pereira, C. Pereira, I. B. Peterson, A. Piepke, S. Pierson, S. Powell, R. M. Preece, K. Pushkin, Y. Qie, M. Racine, B. N. Ratcliff, J. Reichenbacher, L. Reichhart, C. A. Rhyne, A. Richards, Q. Riffard, G. R. C. Rischbieter, J. P. Rodrigues, H. J. Rose, R. Rosero, P. Rossiter, R. Rucinski, G. Rutherford, J. S. Saba, L. Sabarots, D. Santone, M. Sarychev, A. B. M. R. Sazzad, R. W. Schnee, M. Schubnell, P. R. Scovell, M. Severson, D. Seymour, S. Shaw, G. W. Shutt, T. A. Shutt, J. J. Silk, C. Silva, K. Skarpaas, W. Skulski, A. R. Smith, R. J. Smith, R. E. Smith, J. So, M. Solmaz, V. N. Solovov, P. Sorensen, V. V. Sosnovtsev, I. Stancu, M. R. Stark, S. Stephenson, N. Stern, A. Stevens, T. M. Stiegler, K. Stifter, R. Studley, T. J. Sumner, K. Sundarnath, P. Sutcliffe, N. Swanson, M. Szydagis, M. Tan, W. C. Taylor, R. Taylor, D. J. Taylor, D. Temples, B. P. Tennyson, P. A. Terman, K. J. Thomas, J. A. Thomson, D. R. Tiedt, M. Timalsina, W. H. To, A. Tomás, T. E. Tope, M. Tripathi, D. R. Tronstad, C. E. Tull, W. Turner, L. Tvrznikova, M. Utes, U. Utku, S. Uvarov, J. Va’vra, A. Vacheret, A. Vaitkus, J. R. Verbus, T. Vietanen, E. Voirin, C. O. Vuosalo, S. Walcott, W. L. Waldron, K. Walker, J. J. Wang, R. Wang, L. Wang, W. Wang, Y. Wang, J. R. Watson, J. Migneault, S. Weatherly, R. C. Webb, W.-Z. Wei, M. While, R. G. White, J. T. White, D. T. White, T. J. Whitis, W. J. Wisniewski, K. Wilson, M. S. Witherell, F. L. H. Wolfs, J. D. Wolfs, D. Woodward, S. D. Worm, X. Xiang, Q. Xiao, J. Xu, M. Yeh, J. Yin, I. Young, C. Zhang, and P. Zarzhitsky
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published: 2022
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13. LUX-ZEPLIN (LZ) Technical Design Report

Author: Mount, B. J., Hans, S., Rosero, R., Yeh, M., Chan, C., Gaitskell, R. J., Huang, D. Q., Makkinje, J., Malling, D. C., Pangilinan, M., Rhyne, C. A., Taylor, W. C., Verbus, J. R., Kim, Y. D., Lee, H. S., Lee, J., Leonard, D. S., Li, J., Belle, J., Cottle, A., Lippincott, W. H., Markley, D. J., Martin, T. J., Sarychev, M., Tope, T. E., Utes, M., Wang, R., Young, I., Araújo, H. M., Bailey, A. J., Bauer, D., Colling, D., Currie, A., Fayer, S., Froborg, F., Greenwood, S., Jones, W. G., Kasey, V., Khaleeq, M., Olcina, I., Paredes, B. López, Richards, A., Sumner, T. J., Tomás, A., Vacheret, A., Brás, P., Lindote, A., Lopes, M. I., Neves, F., Rodrigues, J. P., Silva, C., Solovov, V. N., Barry, M. J., Cole, A., Dobi, A., Edwards, W. R., Faham, C. H., Fiorucci, S., Gantos, N. J., Gehman, V. M., Gilchriese, M. G. D., Hanzel, K., Hoff, M. D., Kamdin, K., Lesko, K. T., McConnell, C. T., O'Sullivan, K., Oliver-Mallory, K. C., Patton, S. J., Saba, J. S., Sorensen, P., Thomas, K. J., Tull, C. E., Waldron, W. L., Witherell, M. S., Bernstein, A., Kazkaz, K., Xu, J., Akimov, D. Yu., Bolozdynya, A. I., Khromov, A. V., Konovalov, A. M., Kumpan, A. V., Sosnovtsev, V. V., Dahl, C. E., Temples, D., Carmona-Benitez, M. C., de Viveiros, L., Akerib, D. S., Auyeung, H., Biesiadzinski, T. P., Breidenbach, M., Bramante, R., Conley, R., Craddock, W. W., Fan, A., Hau, A., Ignarra, C. M., Ji, W., Krebs, H. J., Linehan, R., Lee, C., Luitz, S., Mizrachi, E., Monzani, M. E., O'Neill, F. G., Pierson, S., Racine, M., Ratcliff, B. N., Shutt, G. W., Shutt, T. A., Skarpaas, K., Stifter, K., To, W. H., Va'vra, J., Whitis, T. J., Wisniewski, W. J., Bai, X., Bunker, R., Coughlen, R., Hjemfelt, C., Leonard, R., Miller, E. H., Morrison, E., Reichenbacher, J., Schnee, R. W., Stark, M. R., Sundarnath, K., Tiedt, D. R., Timalsina, M., Bauer, P., Carlson, B., Horn, M., Johnson, M., Keefner, J., Maupin, C., Taylor, D. J., Balashov, S., Ford, P., Francis, V., Holtom, E., Khazov, A., Kaboth, A., Majewski, P., Nikkel, J. A., O'Dell, J., Preece, R. M., van der Grinten, M. G. D., Worm, S. D., Mannino, R. L., Stiegler, T. M., Terman, P. A., Webb, R. C., Levy, C., Mock, J., Szydagis, M., Busenitz, J. K., Elnimr, M., Hor, J. Y-K., Meng, Y., Piepke, A., Stancu, I., Kreczko, L., Krikler, B., Penning, B., Bernard, E. P., Jacobsen, R. G., McKinsey, D. N., Watson, R., Cutter, J. E., El-Jurf, S., Gerhard, R. M., Hemer, D., Hillbrand, S., Holbrook, B., Lenardo, B. G., Manalaysay, A. G., Morad, J. A., Stephenson, S., Thomson, J. A., Tripathi, M., Uvarov, S., Haselschwardt, S. J., Kyre, S., Nehrkorn, C., Nelson, H. N., Solmaz, M., White, D. T., Cascella, M., Dobson, J. E. Y., Ghag, C., Liu, X., Manenti, L., Reichhart, L., Shaw, S., Utku, U., Beltrame, P., Davison, T. J. R., Marzioni, M. F., Murphy, A. St. J., Nilima, A., Boxer, B., Burdin, S., Greenall, A., Powell, S., Rose, H. J., Sutcliffe, P., Balajthy, J., Edberg, T. K., Hall, C. R., Silk, J. S., Hertel, S., Akerlof, C. W., Arthurs, M., Lorenzon, W., Pushkin, K., Schubnell, M., Boast, K. E., Carels, C., Fruth, T., Kraus, H., Liao, F. -T., Lin, J., Scovell, P. R., Druszkiewicz, E., Khaitan, D., Koyuncu, M., Skulski, W., Wolfs, F. L. H., Yin, J., Korolkova, E. V., Kudryavtsev, V. A., Rossiter, P., Woodward, D., Chiller, A. A., Chiller, C., Mei, D. -M., Wang, L., Wei, W. -Z., While, M., Zhang, C., Alsum, S. K., Benson, T., Carlsmith, D. L., Cherwinka, J. J., Dasu, S., Gregerson, G., Gomber, B., Pagac, A., Palladino, K. J., Vuosalo, C. O., Xiao, Q., Buckley, J. H., Bugaev, V. V., Olevitch, M. A., Boulton, E. M., Emmet, W. T., Hurteau, T. W., Larsen, N. A., Pease, E. K., Tennyson, B. P., and Tvrznikova, L.
Subjects: Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract: In this Technical Design Report (TDR) we describe the LZ detector to be built at the Sanford Underground Research Facility (SURF). The LZ dark matter experiment is designed to achieve sensitivity to a WIMP-nucleon spin-independent cross section of three times ten to the negative forty-eighth square centimeters., Comment: 392 pages. Submitted to the Department of Energy as part of the documentation for the Critical Decision Numbers Two and Three (CD-2 and CD-3) management processes. Report also available by chapter at this URL
Published: 2017

14. Heptanoate Improves Compensatory Mechanism of Glucose Homeostasis in Mitochondrial Long-Chain Fatty Acid Oxidation Defect

Author: Siti Nurjanah, Albert Gerding, Marcel A. Vieira-Lara, Bernard Evers, Miriam Langelaar-Makkinje, Ute Spiekerkoetter, Barbara M. Bakker, and Sara Tucci
Subjects: fatty acid oxidation disorder, glycerol, glucose homeostasis, heptanoate, stable isotope, very long-chain acyl-CoA dehydrogenase, Nutrition. Foods and food supply, TX341-641
Abstract: Defects in mitochondrial fatty acid β-oxidation (FAO) impair metabolic flexibility, which is an essential process for energy homeostasis. Very-long-chain acyl-CoA dehydrogenase (VLCADD; OMIM 609575) deficiency is the most common long-chain mitochondrial FAO disorder presenting with hypoglycemia as a common clinical manifestation. To prevent hypoglycemia, triheptanoin—a triglyceride composed of three heptanoates (C7) esterified with a glycerol backbone—can be used as a dietary treatment, since it is metabolized into precursors for gluconeogenesis. However, studies investigating the effect of triheptanoin on glucose homeostasis are limited. To understand the role of gluconeogenesis in the pathophysiology of long-chain mitochondrial FAO defects, we injected VLCAD-deficient (VLCAD−/−) mice with 13C3-glycerol in the presence and absence of heptanoate (C7). The incorporation of 13C3-glycerol into blood glucose was higher in VLCAD−/− mice than in WT mice, whereas the difference disappeared in the presence of C7. The result correlates with 13C enrichment of liver metabolites in VLCAD−/− mice. In contrast, the C7 bolus significantly decreased the 13C enrichment. These data suggest that the increased contribution of gluconeogenesis to the overall glucose production in VLCAD−/− mice increases the need for gluconeogenesis substrate, thereby avoiding hypoglycemia. Heptanoate is a suitable substrate to induce glucose production in mitochondrial FAO defect.
Published: 2023
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15. LUX-ZEPLIN (LZ) Technical Design Report

Author: Mount, BJ, Hans, S, Rosero, R, Yeh, M, Chan, C, Gaitskell, RJ, Huang, DQ, Makkinje, J, Malling, DC, Pangilinan, M, Rhyne, CA, Taylor, WC, Verbus, JR, Kim, YD, Lee, HS, Lee, J, Leonard, DS, Li, J, Belle, J, Cottle, A, Lippincott, WH, Markley, DJ, Martin, TJ, Sarychev, M, Tope, TE, Utes, M, Wang, R, Young, I, Araújo, HM, Bailey, AJ, Bauer, D, Colling, D, Currie, A, Fayer, S, Froborg, F, Greenwood, S, Jones, WG, Kasey, V, Khaleeq, M, Olcina, I, Paredes, B López, Richards, A, Sumner, TJ, Tomás, A, Vacheret, A, Brás, P, Lindote, A, Lopes, MI, Neves, F, Rodrigues, JP, Silva, C, Solovov, VN, Barry, MJ, Cole, A, Dobi, A, Edwards, WR, Faham, CH, Fiorucci, S, Gantos, NJ, Gehman, VM, Gilchriese, MGD, Hanzel, K, Hoff, MD, Kamdin, K, Lesko, KT, McConnell, CT, O'Sullivan, K, Oliver-Mallory, KC, Patton, SJ, Saba, JS, Sorensen, P, Thomas, KJ, Tull, CE, Waldron, WL, Witherell, MS, Bernstein, A, Kazkaz, K, Xu, J, Akimov, D Yu, Bolozdynya, AI, Khromov, AV, Konovalov, AM, Kumpan, AV, Sosnovtsev, VV, Dahl, CE, Temples, D, Carmona-Benitez, MC, Viveiros, L de, Akerib, DS, Auyeung, H, Biesiadzinski, TP, Breidenbach, M, Bramante, R, Conley, R, Craddock, WW, Fan, A, Hau, A, Ignarra, CM, Ji, W, and Krebs, HJ
Subjects: physics.ins-det, astro-ph.IM, hep-ex
Abstract: In this Technical Design Report (TDR) we describe the LZ detector to be builtat the Sanford Underground Research Facility (SURF). The LZ dark matterexperiment is designed to achieve sensitivity to a WIMP-nucleonspin-independent cross section of three times ten to the negative forty-eighthsquare centimeters.
Published: 2017

16. An Analysis of Physics Graduate Admission Data

Author: Makkinje, Jan A.
Subjects: Physics - Physics Education
Abstract: We use self-reported data from 2011--2014 and determine the academic profile of accepted students at physics graduate programs in the United States. We analyze the accepted students' grade point averages and physics Graduate Record Examination (GRE) scores. We also compare the physics GRE scores of accepted students to their grade point averages., Comment: 3 pages, 4 figures
Published: 2015

17. Erratum to: The LUX-ZEPLIN (LZ) radioactivity and cleanliness control programs

Author: Akerib, D. S., Akerlof, C. W., Akimov, D. Yu., Alquahtani, A., Alsum, S. K., Anderson, T. J., Angelides, N., Araújo, H. M., Arbuckle, A., Armstrong, J. E., Arthurs, M., Auyeung, H., Aviles, S., Bai, X., Bailey, A. J., Balajthy, J., Balashov, S., Bang, J., Barry, M. J., Bauer, D., Bauer, P., Baxter, A., Belle, J., Beltrame, P., Bensinger, J., Benson, T., Bernard, E. P., Bernstein, A., Bhatti, A., Biekert, A., Biesiadzinski, T. P., Birch, H. J., Birrittella, B., Boast, K. E., Bolozdynya, A. I., Boulton, E. M., Boxer, B., Bramante, R., Branson, S., Brás, P., Breidenbach, M., Brew, C. A. J., Buckley, J. H., Bugaev, V. V., Bunker, R., Burdin, S., Busenitz, J. K., Cabrita, R., Campbell, J. S., Carels, C., Carlsmith, D. L., Carlson, B., Carmona-Benitez, M. C., Cascella, M., Chan, C., Cherwinka, J. J., Chiller, A. A., Chiller, C., Chott, N. I., Cole, A., Coleman, J., Colling, D., Conley, R. A., Cottle, A., Coughlen, R., Cox, G., Craddock, W. W., Curran, D., Currie, A., Cutter, J. E., da Cunha, J. P., Dahl, C. E., Dardin, S., Dasu, S., Davis, J., Davison, T. J. R., de Viveiros, L., Decheine, N., Dobi, A., Dobson, J. E. Y., Druszkiewicz, E., Dushkin, A., Edberg, T. K., Edwards, W. R., Edwards, B. N., Edwards, J., Elnimr, M. M., Emmet, W. T., Eriksen, S. R., Faham, C. H., Fan, A., Fayer, S., Fiorucci, S., Flaecher, H., Florang, I. M. Fogarty, Ford, P., Francis, V. B., Fraser, E. D., Froborg, F., Fruth, T., Gaitskell, R. J., Gantos, N. J., Garcia, D., Gehman, V. M., Gelfand, R., Genovesi, J., Gerhard, R. M., Ghag, C., Gibson, E., Gilchriese, M. G. D., Gokhale, S., Gomber, B., Gonda, T. G., Greenall, A., Greenwood, S., Gregerson, G., van der Grinten, M. G. D., Gwilliam, C. B., Hall, C. R., Hamilton, D., Hans, S., Hanzel, K., Harrington, T., Harrison, A., Harrison, J., Hasselkus, C., Haselschwardt, S. J., Hemer, D., Hertel, S. A., Heise, J., Hillbrand, S., Hitchcock, O., Hjemfelt, C., Hoff, M. D., Holbrook, B., Holtom, E., Hor, J. Y-K., Horn, M., Huang, D. Q., Hurteau, T. W., Ignarra, C. M., Irving, M. N., Jacobsen, R. G., Jahangir, O., Jeffery, S. N., Ji, W., Johnson, M., Johnson, J., Johnson, P., Jones, W. G., Kaboth, A. C., Kamaha, A., Kamdin, K., Kasey, V., Kazkaz, K., Keefner, J., Khaitan, D., Khaleeq, M., Khazov, A., Khromov, A. V., Khurana, I., Kim, Y. D., Kim, W. T., Kocher, C. D., Kodroff, D., Konovalov, A. M., Korley, L., Korolkova, E. V., Koyuncu, M., Kras, J., Kraus, H., Kravitz, S. W., Krebs, H. J., Kreczko, L., Krikler, B., Kudryavtsev, V. A., Kumpan, A. V., Kyre, S., Lambert, A. R., Landerud, B., Larsen, N. A., Laundrie, A., Leason, E. A., Lee, H. S., Lee, J., Lee, C., Lenardo, B. G., Leonard, D. S., Leonard, R., Lesko, K. T., Levy, C., Li, J., Liu, Y., Liao, J., Liao, F.-T., Lin, J., Lindote, A., Linehan, R., Lippincott, W. H., Liu, R., Liu, X., Loniewski, C., Lopes, M. I., Lopez-Asamar, E., Paredes, B. López, Lorenzon, W., Lucero, D., Luitz, S., Lyle, J. M., Lynch, C., Majewski, P. A., Makkinje, J., Malling, D. C., Manalaysay, A., Manenti, L., Mannino, R. L., Marangou, N., Markley, D. J., MarrLaundrie, P., Martin, T. J., Marzioni, M. F., Maupin, C., McConnell, C. T., McKinsey, D. N., McLaughlin, J., Mei, D.-M., Meng, Y., Miller, E. H., Minaker, Z. J., Mizrachi, E., Mock, J., Molash, D., Monte, A., Monzani, M. E., Morad, J. A., Morrison, E., Mount, B. J., Murphy, A. St. J., Naim, D., Naylor, A., Nedlik, C., Nehrkorn, C., Nelson, H. N., Nesbit, J., Neves, F., Nikkel, J. A., Nikoleyczik, J. A., Nilima, A., O’Dell, J., Oh, H., O’Neill, F. G., O’Sullivan, K., Olcina, I., Olevitch, M. A., Oliver-Mallory, K. C., Oxborough, L., Pagac, A., Pagenkopf, D., Pal, S., Palladino, K. J., Palmaccio, V. M., Palmer, J., Pangilinan, M., Parveen, N., Patton, S. J., Pease, E. K., Penning, B. P., Pereira, G., Pereira, C., Peterson, I. B., Piepke, A., Pierson, S., Powell, S., Preece, R. M., Pushkin, K., Qie, Y., Racine, M., Ratcliff, B. N., Reichenbacher, J., Reichhart, L., Rhyne, C. A., Richards, A., Riffard, Q., Rischbieter, G. R. C., Rodrigues, J. P., Rose, H. J., Rosero, R., Rossiter, P., Rucinski, R., Rutherford, G., Saba, J. S., Sabarots, L., Santone, D., Sarychev, M., Sazzad, A. B. M. R., Schnee, R. W., Schubnell, M., Scovell, P. R., Severson, M., Seymour, D., Shaw, S., Shutt, G. W., Shutt, T. A., Silk, J. J., Silva, C., Skarpaas, K., Skulski, W., Smith, A. R., Smith, R. J., Smith, R. E., So, J., Solmaz, M., Solovov, V. N., Sorensen, P., Sosnovtsev, V. V., Stancu, I., Stark, M. R., Stephenson, S., Stern, N., Stevens, A., Stiegler, T. M., Stifter, K., Studley, R., Sumner, T. J., Sundarnath, K., Sutcliffe, P., Swanson, N., Szydagis, M., Tan, M., Taylor, W. C., Taylor, R., Taylor, D. J., Temples, D., Tennyson, B. P., Terman, P. A., Thomas, K. J., Thomson, J. A., Tiedt, D. R., Timalsina, M., To, W. H., Tomás, A., Tope, T. E., Tripathi, M., Tronstad, D. R., Tull, C. E., Turner, W., Tvrznikova, L., Utes, M., Utku, U., Uvarov, S., Va’vra, J., Vacheret, A., Vaitkus, A., Verbus, J. R., Vietanen, T., Voirin, E., Vuosalo, C. O., Walcott, S., Waldron, W. L., Walker, K., Wang, J. J., Wang, R., Wang, L., Wang, W., Wang, Y., Watson, J. R., Migneault, J., Weatherly, S., Webb, R. C., Wei, W.-Z., While, M., White, R. G., White, J. T., White, D. T., Whitis, T. J., Wisniewski, W. J., Wilson, K., Witherell, M. S., Wolfs, F. L. H., Wolfs, J. D., Woodward, D., Worm, S. D., Xiang, X., Xiao, Q., Xu, J., Yeh, M., Yin, J., Young, I., Zhang, C., and Zarzhitsky, P.
Published: 2022
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18. The LUX-ZEPLIN (LZ) experiment

Author: Akerib, D.S., Akerlof, C.W., Akimov, D.Yu., Alquahtani, A., Alsum, S.K., Anderson, T.J., Angelides, N., Araújo, H.M., Arbuckle, A., Armstrong, J.E., Arthurs, M., Auyeung, H., Bai, X., Bailey, A.J., Balajthy, J., Balashov, S., Bang, J., Barry, M.J., Barthel, J., Bauer, D., Bauer, P., Baxter, A., Belle, J., Beltrame, P., Bensinger, J., Benson, T., Bernard, E.P., Bernstein, A., Bhatti, A., Biekert, A., Biesiadzinski, T.P., Birrittella, B., Boast, K.E., Bolozdynya, A.I., Boulton, E.M., Boxer, B., Bramante, R., Branson, S., Brás, P., Breidenbach, M., Buckley, J.H., Bugaev, V.V., Bunker, R., Burdin, S., Busenitz, J.K., Campbell, J.S., Carels, C., Carlsmith, D.L., Carlson, B., Carmona-Benitez, M.C., Cascella, M., Chan, C., Cherwinka, J.J., Chiller, A.A., Chiller, C., Chott, N.I., Cole, A., Coleman, J., Colling, D., Conley, R.A., Cottle, A., Coughlen, R., Craddock, W.W., Curran, D., Currie, A., Cutter, J.E., da Cunha, J.P., Dahl, C.E., Dardin, S., Dasu, S., Davis, J., Davison, T.J.R., de Viveiros, L., Decheine, N., Dobi, A., Dobson, J.E.Y., Druszkiewicz, E., Dushkin, A., Edberg, T.K., Edwards, W.R., Edwards, B.N., Edwards, J., Elnimr, M.M., Emmet, W.T., Eriksen, S.R., Faham, C.H., Fan, A., Fayer, S., Fiorucci, S., Flaecher, H., Fogarty Florang, I.M., Ford, P., Francis, V.B., Froborg, F., Fruth, T., Gaitskell, R.J., Gantos, N.J., Garcia, D., Geffre, A., Gehman, V.M., Gelfand, R., Genovesi, J., Gerhard, R.M., Ghag, C., Gibson, E., Gilchriese, M.G.D., Gokhale, S., Gomber, B., Gonda, T.G., Greenall, A., Greenwood, S., Gregerson, G., van der Grinten, M.G.D., Gwilliam, C.B., Hall, C.R., Hamilton, D., Hans, S., Hanzel, K., Harrington, T., Harrison, A., Hasselkus, C., Haselschwardt, S.J., Hemer, D., Hertel, S.A., Heise, J., Hillbrand, S., Hitchcock, O., Hjemfelt, C., Hoff, M.D., Holbrook, B., Holtom, E., Hor, J.Y-K., Horn, M., Huang, D.Q., Hurteau, T.W., Ignarra, C.M., Irving, M.N., Jacobsen, R.G., Jahangir, O., Jeffery, S.N., Ji, W., Johnson, M., Johnson, J., Johnson, P., Jones, W.G., Kaboth, A.C., Kamaha, A., Kamdin, K., Kasey, V., Kazkaz, K., Keefner, J., Khaitan, D., Khaleeq, M., Khazov, A., Khromov, A.V., Khurana, I., Kim, Y.D., Kim, W.T., Kocher, C.D., Konovalov, A.M., Korley, L., Korolkova, E.V., Koyuncu, M., Kras, J., Kraus, H., Kravitz, S.W., Krebs, H.J., Kreczko, L., Krikler, B., Kudryavtsev, V.A., Kumpan, A.V., Kyre, S., Lambert, A.R., Landerud, B., Larsen, N.A., Laundrie, A., Leason, E.A., Lee, H.S., Lee, J., Lee, C., Lenardo, B.G., Leonard, D.S., Leonard, R., Lesko, K.T., Levy, C., Li, J., Liu, Y., Liao, J., Liao, F.-T., Lin, J., Lindote, A., Linehan, R., Lippincott, W.H., Liu, R., Liu, X., Loniewski, C., Lopes, M.I., López Paredes, B., Lorenzon, W., Lucero, D., Luitz, S., Lyle, J.M., Lynch, C., Majewski, P.A., Makkinje, J., Malling, D.C., Manalaysay, A., Manenti, L., Mannino, R.L., Marangou, N., Markley, D.J., MarrLaundrie, P., Martin, T.J., Marzioni, M.F., Maupin, C., McConnell, C.T., McKinsey, D.N., McLaughlin, J., Mei, D.-M., Meng, Y., Miller, E.H., Minaker, Z.J., Mizrachi, E., Mock, J., Molash, D., Monte, A., Monzani, M.E., Morad, J.A., Morrison, E., Mount, B.J., Murphy, A.St.J., Naim, D., Naylor, A., Nedlik, C., Nehrkorn, C., Nelson, H.N., Nesbit, J., Neves, F., Nikkel, J.A., Nikoleyczik, J.A., Nilima, A., O’Dell, J., Oh, H., O’Neill, F.G., O’Sullivan, K., Olcina, I., Olevitch, M.A., Oliver-Mallory, K.C., Oxborough, L., Pagac, A., Pagenkopf, D., Pal, S., Palladino, K.J., Palmaccio, V.M., Palmer, J., Pangilinan, M., Patton, S.J., Pease, E.K., Penning, B.P., Pereira, G., Pereira, C., Peterson, I.B., Piepke, A., Pierson, S., Powell, S., Preece, R.M., Pushkin, K., Qie, Y., Racine, M., Ratcliff, B.N., Reichenbacher, J., Reichhart, L., Rhyne, C.A., Richards, A., Riffard, Q., Rischbieter, G.R.C., Rodrigues, J.P., Rose, H.J., Rosero, R., Rossiter, P., Rucinski, R., Rutherford, G., Rynders, D., Saba, J.S., Sabarots, L., Santone, D., Sarychev, M., Sazzad, A.B.M.R., Schnee, R.W., Schubnell, M., Scovell, P.R., Severson, M., Seymour, D., Shaw, S., Shutt, G.W., Shutt, T.A., Silk, J.J., Silva, C., Skarpaas, K., Skulski, W., Smith, A.R., Smith, R.J., Smith, R.E., So, J., Solmaz, M., Solovov, V.N., Sorensen, P., Sosnovtsev, V.V., Stancu, I., Stark, M.R., Stephenson, S., Stern, N., Stevens, A., Stiegler, T.M., Stifter, K., Studley, R., Sumner, T.J., Sundarnath, K., Sutcliffe, P., Swanson, N., Szydagis, M., Tan, M., Taylor, W.C., Taylor, R., Taylor, D.J., Temples, D., Tennyson, B.P., Terman, P.A., Thomas, K.J., Thomson, J.A., Tiedt, D.R., Timalsina, M., To, W.H., Tomás, A., Tope, T.E., Tripathi, M., Tronstad, D.R., Tull, C.E., Turner, W., Tvrznikova, L., Utes, M., Utku, U., Uvarov, S., Va’vra, J., Vacheret, A., Vaitkus, A., Verbus, J.R., Vietanen, T., Voirin, E., Vuosalo, C.O., Walcott, S., Waldron, W.L., Walker, K., Wang, J.J., Wang, R., Wang, L., Wang, Y., Watson, J.R., Migneault, J., Weatherly, S., Webb, R.C., Wei, W.-Z., While, M., White, R.G., White, J.T., White, D.T., Whitis, T.J., Wisniewski, W.J., Wilson, K., Witherell, M.S., Wolfs, F.L.H., Wolfs, J.D., Woodward, D., Worm, S.D., Xiang, X., Xiao, Q., Xu, J., Yeh, M., Yin, J., Young, I., and Zhang, C.
Published: 2020
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19. A Simple Apparatus for the Direct Measurement of Magnetic Forces and Magnetic Properties of Materials

Author: Makkinje, Jan A. and Zimmerman, George O.
Subjects: Condensed Matter - Materials Science, Physics - Instrumentation and Detectors
Abstract: In this paper, we describe a simple apparatus consisting of a scale, capable of a one milligram resolution, and a commonly obtainable magnet to measure magnetic forces. This simple apparatus is capable of measuring magnetic properties of materials in either a research or an instructional laboratory. We illustrate the capability of this apparatus by the measurement of the force of iron samples exerted on the magnet, the force of a paramagnetic sample, that by a current carrying wire, and the force of a high temperature superconductor.
Published: 2014

20. The LUX-ZEPLIN (LZ) radioactivity and cleanliness control programs

Author: D. S. Akerib, C. W. Akerlof, D. Yu. Akimov, A. Alquahtani, S. K. Alsum, T. J. Anderson, N. Angelides, H. M. Araújo, A. Arbuckle, J. E. Armstrong, M. Arthurs, H. Auyeung, S. Aviles, X. Bai, A. J. Bailey, J. Balajthy, S. Balashov, J. Bang, M. J. Barry, D. Bauer, P. Bauer, A. Baxter, J. Belle, P. Beltrame, J. Bensinger, T. Benson, E. P. Bernard, A. Bernstein, A. Bhatti, A. Biekert, T. P. Biesiadzinski, H. J. Birch, B. Birrittella, K. E. Boast, A. I. Bolozdynya, E. M. Boulton, B. Boxer, R. Bramante, S. Branson, P. Brás, M. Breidenbach, C. A. J. Brew, J. H. Buckley, V. V. Bugaev, R. Bunker, S. Burdin, J. K. Busenitz, R. Cabrita, J. S. Campbell, C. Carels, D. L. Carlsmith, B. Carlson, M. C. Carmona-Benitez, M. Cascella, C. Chan, J. J. Cherwinka, A. A. Chiller, C. Chiller, N. I. Chott, A. Cole, J. Coleman, D. Colling, R. A. Conley, A. Cottle, R. Coughlen, G. Cox, W. W. Craddock, D. Curran, A. Currie, J. E. Cutter, J. P. da Cunha, C. E. Dahl, S. Dardin, S. Dasu, J. Davis, T. J. R. Davison, L. de Viveiros, N. Decheine, A. Dobi, J. E. Y. Dobson, E. Druszkiewicz, A. Dushkin, T. K. Edberg, W. R. Edwards, B. N. Edwards, J. Edwards, M. M. Elnimr, W. T. Emmet, S. R. Eriksen, C. H. Faham, A. Fan, S. Fayer, S. Fiorucci, H. Flaecher, I. M. Fogarty Florang, P. Ford, V. B. Francis, E. D. Fraser, F. Froborg, T. Fruth, R. J. Gaitskell, N. J. Gantos, D. Garcia, V. M. Gehman, R. Gelfand, J. Genovesi, R. M. Gerhard, C. Ghag, E. Gibson, M. G. D. Gilchriese, S. Gokhale, B. Gomber, T. G. Gonda, A. Greenall, S. Greenwood, G. Gregerson, M. G. D. van der Grinten, C. B. Gwilliam, C. R. Hall, D. Hamilton, S. Hans, K. Hanzel, T. Harrington, A. Harrison, J. Harrison, C. Hasselkus, S. J. Haselschwardt, D. Hemer, S. A. Hertel, J. Heise, S. Hillbrand, O. Hitchcock, C. Hjemfelt, M. D. Hoff, B. Holbrook, E. Holtom, J. Y-K. Hor, M. Horn, D. Q. Huang, T. W. Hurteau, C. M. Ignarra, M. N. Irving, R. G. Jacobsen, O. Jahangir, S. N. Jeffery, W. Ji, M. Johnson, J. Johnson, P. Johnson, W. G. Jones, A. C. Kaboth, A. Kamaha, K. Kamdin, V. Kasey, K. Kazkaz, J. Keefner, D. Khaitan, M. Khaleeq, A. Khazov, A. V. Khromov, I. Khurana, Y. D. Kim, W. T. Kim, C. D. Kocher, D. Kodroff, A. M. Konovalov, L. Korley, E. V. Korolkova, M. Koyuncu, J. Kras, H. Kraus, S. W. Kravitz, H. J. Krebs, L. Kreczko, B. Krikler, V. A. Kudryavtsev, A. V. Kumpan, S. Kyre, A. R. Lambert, B. Landerud, N. A. Larsen, A. Laundrie, E. A. Leason, H. S. Lee, J. Lee, C. Lee, B. G. Lenardo, D. S. Leonard, R. Leonard, K. T. Lesko, C. Levy, J. Li, Y. Liu, J. Liao, F.-T. Liao, J. Lin, A. Lindote, R. Linehan, W. H. Lippincott, R. Liu, X. Liu, C. Loniewski, M. I. Lopes, E. Lopez-Asamar, B. López Paredes, W. Lorenzon, D. Lucero, S. Luitz, J. M. Lyle, C. Lynch, P. A. Majewski, J. Makkinje, D. C. Malling, A. Manalaysay, L. Manenti, R. L. Mannino, N. Marangou, D. J. Markley, P. MarrLaundrie, T. J. Martin, M. F. Marzioni, C. Maupin, C. T. McConnell, D. N. McKinsey, J. McLaughlin, D.-M. Mei, Y. Meng, E. H. Miller, Z. J. Minaker, E. Mizrachi, J. Mock, D. Molash, A. Monte, M. E. Monzani, J. A. Morad, E. Morrison, B. J. Mount, A. St. J. Murphy, D. Naim, A. Naylor, C. Nedlik, C. Nehrkorn, H. N. Nelson, J. Nesbit, F. Neves, J. A. Nikkel, J. A. Nikoleyczik, A. Nilima, J. O’Dell, H. Oh, F. G. O’Neill, K. O’Sullivan, I. Olcina, M. A. Olevitch, K. C. Oliver-Mallory, L. Oxborough, A. Pagac, D. Pagenkopf, S. Pal, K. J. Palladino, V. M. Palmaccio, J. Palmer, M. Pangilinan, N. Parveen, S. J. Patton, E. K. Pease, B. P. Penning, G. Pereira, C. Pereira, I. B. Peterson, A. Piepke, S. Pierson, S. Powell, R. M. Preece, K. Pushkin, Y. Qie, M. Racine, B. N. Ratcliff, J. Reichenbacher, L. Reichhart, C. A. Rhyne, A. Richards, Q. Riffard, G. R. C. Rischbieter, J. P. Rodrigues, H. J. Rose, R. Rosero, P. Rossiter, R. Rucinski, G. Rutherford, J. S. Saba, L. Sabarots, D. Santone, M. Sarychev, A. B. M. R. Sazzad, R. W. Schnee, M. Schubnell, P. R. Scovell, M. Severson, D. Seymour, S. Shaw, G. W. Shutt, T. A. Shutt, J. J. Silk, C. Silva, K. Skarpaas, W. Skulski, A. R. Smith, R. J. Smith, R. E. Smith, J. So, M. Solmaz, V. N. Solovov, P. Sorensen, V. V. Sosnovtsev, I. Stancu, M. R. Stark, S. Stephenson, N. Stern, A. Stevens, T. M. Stiegler, K. Stifter, R. Studley, T. J. Sumner, K. Sundarnath, P. Sutcliffe, N. Swanson, M. Szydagis, M. Tan, W. C. Taylor, R. Taylor, D. J. Taylor, D. Temples, B. P. Tennyson, P. A. Terman, K. J. Thomas, J. A. Thomson, D. R. Tiedt, M. Timalsina, W. H. To, A. Tomás, T. E. Tope, M. Tripathi, D. R. Tronstad, C. E. Tull, W. Turner, L. Tvrznikova, M. Utes, U. Utku, S. Uvarov, J. Va’vra, A. Vacheret, A. Vaitkus, J. R. Verbus, T. Vietanen, E. Voirin, C. O. Vuosalo, S. Walcott, W. L. Waldron, K. Walker, J. J. Wang, R. Wang, L. Wang, W. Wang, Y. Wang, J. R. Watson, J. Migneault, S. Weatherly, R. C. Webb, W.-Z. Wei, M. While, R. G. White, J. T. White, D. T. White, T. J. Whitis, W. J. Wisniewski, K. Wilson, M. S. Witherell, F. L. H. Wolfs, J. D. Wolfs, D. Woodward, S. D. Worm, X. Xiang, Q. Xiao, J. Xu, M. Yeh, J. Yin, I. Young, C. Zhang, and P. Zarzhitsky
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract LUX-ZEPLIN (LZ) is a second-generation direct dark matter experiment with spin-independent WIMP-nucleon scattering sensitivity above $${1.4 \times 10^{-48}}\, {\hbox {cm}}^{2}$$ 1.4 × 10 - 48 cm 2 for a WIMP mass of $${40}\, \hbox {GeV}/{\hbox {c}}^{2}$$ 40 GeV / c 2 and a $${1000}\, \hbox {days}$$ 1000 days exposure. LZ achieves this sensitivity through a combination of a large $${5.6}\, \hbox {t}$$ 5.6 t fiducial volume, active inner and outer veto systems, and radio-pure construction using materials with inherently low radioactivity content. The LZ collaboration performed an extensive radioassay campaign over a period of six years to inform material selection for construction and provide an input to the experimental background model against which any possible signal excess may be evaluated. The campaign and its results are described in this paper. We present assays of dust and radon daughters depositing on the surface of components as well as cleanliness controls necessary to maintain background expectations through detector construction and assembly. Finally, examples from the campaign to highlight fixed contaminant radioassays for the LZ photomultiplier tubes, quality control and quality assurance procedures through fabrication, radon emanation measurements of major sub-systems, and bespoke detector systems to assay scintillator are presented.
Published: 2020
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21. Common genetic variants influence human subcortical brain structures

Author: Hibar, Derrek P, Stein, Jason L, Renteria, Miguel E, Arias-Vasquez, Alejandro, Desrivières, Sylvane, Jahanshad, Neda, Toro, Roberto, Wittfeld, Katharina, Abramovic, Lucija, Andersson, Micael, Aribisala, Benjamin S, Armstrong, Nicola J, Bernard, Manon, Bohlken, Marc M, Boks, Marco P, Bralten, Janita, Brown, Andrew A, Mallar Chakravarty, M, Chen, Qiang, Ching, Christopher RK, Cuellar-Partida, Gabriel, den Braber, Anouk, Giddaluru, Sudheer, Goldman, Aaron L, Grimm, Oliver, Guadalupe, Tulio, Hass, Johanna, Woldehawariat, Girma, Holmes, Avram J, Hoogman, Martine, Janowitz, Deborah, Jia, Tianye, Kim, Sungeun, Klein, Marieke, Kraemer, Bernd, Lee, Phil H, Olde Loohuis, Loes M, Luciano, Michelle, Macare, Christine, Mather, Karen A, Mattheisen, Manuel, Milaneschi, Yuri, Nho, Kwangsik, Papmeyer, Martina, Ramasamy, Adaikalavan, Risacher, Shannon L, Roiz-Santiañez, Roberto, Rose, Emma J, Salami, Alireza, Sämann, Philipp G, Schmaal, Lianne, Schork, Andrew J, Shin, Jean, Strike, Lachlan T, Teumer, Alexander, van Donkelaar, Marjolein MJ, van Eijk, Kristel R, Walters, Raymond K, Westlye, Lars T, Whelan, Christopher D, Winkler, Anderson M, Zwiers, Marcel P, Alhusaini, Saud, Athanasiu, Lavinia, Ehrlich, Stefan, Hakobjan, Marina MH, Hartberg, Cecilie B, Haukvik, Unn K, Heister, Angelien JGAM, Hoehn, David, Kasperaviciute, Dalia, Liewald, David CM, Lopez, Lorna M, Makkinje, Remco RR, Matarin, Mar, Naber, Marlies AM, Reese McKay, D, Needham, Margaret, Nugent, Allison C, Pütz, Benno, Royle, Natalie A, Shen, Li, Sprooten, Emma, Trabzuni, Daniah, van der Marel, Saskia SL, van Hulzen, Kimm JE, Walton, Esther, Wolf, Christiane, Almasy, Laura, Ames, David, Arepalli, Sampath, Assareh, Amelia A, Bastin, Mark E, Brodaty, Henry, Bulayeva, Kazima B, Carless, Melanie A, Cichon, Sven, Corvin, Aiden, Curran, Joanne E, and Czisch, Michael
Subjects: Biological Psychology, Biological Sciences, Genetics, Psychology, Brain Disorders, Human Genome, Mental Health, Neurosciences, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Neurological, Mental health, Adolescent, Adult, Aged, Aged, 80 and over, Aging, Apoptosis, Brain, Caudate Nucleus, Child, Female, Gene Expression Regulation, Developmental, Genetic Loci, Genetic Variation, Genome-Wide Association Study, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Membrane Proteins, Middle Aged, Organ Size, Putamen, Sex Characteristics, Skull, Young Adult, Alzheimer’s Disease Neuroimaging Initiative, CHARGE Consortium, EPIGEN, IMAGEN, SYS, General Science & Technology
Abstract: The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts. We identify five novel genetic variants influencing the volumes of the putamen and caudate nucleus. We also find stronger evidence for three loci with previously established influences on hippocampal volume and intracranial volume. These variants show specific volumetric effects on brain structures rather than global effects across structures. The strongest effects were found for the putamen, where a novel intergenic locus with replicable influence on volume (rs945270; P = 1.08 × 10(-33); 0.52% variance explained) showed evidence of altering the expression of the KTN1 gene in both brain and blood tissue. Variants influencing putamen volume clustered near developmental genes that regulate apoptosis, axon guidance and vesicle transport. Identification of these genetic variants provides insight into the causes of variability in human brain development, and may help to determine mechanisms of neuropsychiatric dysfunction.
Published: 2015

22. Precision-cut liver slices as an ex vivo model to assess impaired hepatic glucose production

Author: Bakker, Barbara, primary, Kiyuna, Ligia Akemi, additional, Krishnamurthy, Kishore Alagere, additional, Langelaar-Makkinje, Miriam, additional, Gerding, Albert, additional, Bos, Trijnie, additional, Oosterhuis, Dorenda, additional, Overduin, Ruben, additional, Schreuder, Andrea B., additional, De Meijer, Vincent, additional, Olinga, Peter, additional, Derks, Terry G.J., additional, Eunen, Karen van, additional, and Oosterveer, Maaike H., additional
Published: 2023
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23. Heptanoate Improves Compensatory Mechanism of Glucose Homeostasis in Mitochondrial Long-Chain Fatty Acid Oxidation Defect

Author: Nurjanah, Siti, primary, Gerding, Albert, additional, Vieira-Lara, Marcel A., additional, Evers, Bernard, additional, Langelaar-Makkinje, Miriam, additional, Spiekerkoetter, Ute, additional, Bakker, Barbara M., additional, and Tucci, Sara, additional
Published: 2023
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24. Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis

Author: Mirkov, Maša Umiċeviċ, Cui, Jing, Vermeulen, Sita H, Stahl, Eli A, Toonen, Erik JM, Makkinje, Remco R, Lee, Annette T, Huizinga, Tom WJ, Allaart, Renee, Barton, Anne, Mariette, Xavier, Miceli, Corinne Richard, Criswell, Lindsey A, Tak, Paul P, de Vries, Niek, Saevarsdottir, Saedis, Padyukov, Leonid, Bridges, S Louis, van Schaardenburg, Dirk-Jan, Jansen, Tim L, Dutmer, Ellen AJ, van de Laar, Mart AFJ, Barrera, Pilar, Radstake, Timothy RDJ, van Riel, Piet LCM, Scheffer, Hans, Franke, Barbara, Brunner, Han G, Plenge, Robert M, Gregersen, Peter K, Guchelaar, Henk-Jan, and Coenen, Marieke JH
Subjects: Biomedical and Clinical Sciences, Clinical Sciences, Immunology, Arthritis, Rheumatoid Arthritis, Genetics, Autoimmune Disease, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Adalimumab, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Antirheumatic Agents, Arthritis, Rheumatoid, DNA Mutational Analysis, Drug Resistance, Etanercept, Female, Gene Expression Regulation, Genetic Markers, Genome-Wide Association Study, Humans, Immunoglobulin G, Infliximab, Male, Polymorphism, Single Nucleotide, Receptors, Tumor Necrosis Factor, Registries, Tumor Necrosis Factor-alpha, Anti-TNF, Gene Polymorphism, Pharmacogenetics, Public Health and Health Services, Arthritis & Rheumatology, Clinical sciences
Abstract: BackgroundTreatment strategies blocking tumour necrosis factor (anti-TNF) have proven very successful in patients with rheumatoid arthritis (RA). However, a significant subset of patients does not respond for unknown reasons. Currently, there are no means of identifying these patients before treatment. This study was aimed at identifying genetic factors predicting anti-TNF treatment outcome in patients with RA using a genome-wide association approach.MethodsWe conducted a multistage, genome-wide association study with a primary analysis of 2 557 253 single-nucleotide polymorphisms (SNPs) in 882 patients with RA receiving anti-TNF therapy included through the Dutch Rheumatoid Arthritis Monitoring (DREAM) registry and the database of Apotheekzorg. Linear regression analysis of changes in the Disease Activity Score in 28 joints after 14 weeks of treatment was performed using an additive model. Markers with p
Published: 2013

25. Rebalancing of mitochondrial homeostasis through an NAD+-SIRT1 pathway preserves intestinal barrier function in severe malnutrition.

Author: Dep Biomolecular Health Sciences, Pathobiologie, Cell Biology, Metabolism & Cancer - Cancer, Ling, Catriona, Versloot, Christian J, Arvidsson Kvissberg, Matilda E, Hu, Guanlan, Swain, Nathan, Horcas-Nieto, José M, Miraglia, Emily, Thind, Mehakpreet K, Farooqui, Amber, Gerding, Albert, van Eunen, Karen, Koster, Mirjam H, Kloosterhuis, Niels J, Chi, Lijun, ChenMi, YueYing, Langelaar-Makkinje, Miriam, Bourdon, Celine, Swann, Jonathan, Smit, Marieke, de Bruin, Alain, Youssef, Sameh A, Feenstra, Marjon, van Dijk, Theo H, Thedieck, Kathrin, Jonker, Johan W, Kim, Peter K, Bakker, Barbara M, Bandsma, Robert H J, Dep Biomolecular Health Sciences, Pathobiologie, Cell Biology, Metabolism & Cancer - Cancer, Ling, Catriona, Versloot, Christian J, Arvidsson Kvissberg, Matilda E, Hu, Guanlan, Swain, Nathan, Horcas-Nieto, José M, Miraglia, Emily, Thind, Mehakpreet K, Farooqui, Amber, Gerding, Albert, van Eunen, Karen, Koster, Mirjam H, Kloosterhuis, Niels J, Chi, Lijun, ChenMi, YueYing, Langelaar-Makkinje, Miriam, Bourdon, Celine, Swann, Jonathan, Smit, Marieke, de Bruin, Alain, Youssef, Sameh A, Feenstra, Marjon, van Dijk, Theo H, Thedieck, Kathrin, Jonker, Johan W, Kim, Peter K, Bakker, Barbara M, and Bandsma, Robert H J
Published: 2023

26. Characterizing the effects of delineation uncertainties in head and neck cancer radiotherapy

Author: Makkinje, Andri (author) and Makkinje, Andri (author)
Abstract: The goal of radiotherapy is to maximize the dose to the target while minimizing the dose to normal tissue. Treatment plans are optimized for this goal and dose delivery is improved in accuracy and precision. The optimization is based on the delineations of the volumes of interest on the medical images of the patient. The problem is that these delineations contain uncertainties and the effect of these uncertainties become more pronounced as the accuracy and precision of dose delivery improves. The delineation uncertainties are caused by various factors such as knowledge and experience of the observers, guidelines, and image quality and modality. The goal of this thesis is to research the effects of delineation uncertainties. Uncertainties are characterized using a rolling ball algorithm (RBA) to modify the delineation. The radius of the ball represents the uncertainty and ranges from -5 mm to 5 mm for the clinical target volume (CTV) and -2 mm to 2 mm for the brain stem. The effect of these uncertainties will be researched for both fixed and re-optimized dose distributions. These are then used as input to create a model that will simulate the dose distributions for different uncertainties using Polynomial Chaos Expansion (PCE). PCE will be used to model dose volume histograms (DVH) of the CTV and the brain stem. The dosimetric effect will be determined by setting confidence intervals in D98% of the CTV and D2% of the brain stem. The widths of the confidence intervals in these two metrics represent the dose uncertainty. This thesis uses three sets of patient data. Each patient had a CTV close to the brain stem. Dose uncertainty in the two metrics was found to increase as the uncertainty of CTV and brain stem delineation increases. For a fixed dose distribution, a delineation uncertainty of 0.75 mm to 1.25 mm in the CTV would lead to a dose uncertainty of 2 Gy in the D98% of the CTV. A delineation uncertainty of 0.25 mm to 0.5 mm in the brain stem would lead to the sam, Applied Physics
Published: 2023

27. Supplementary Table 3 from A First Step toward Personalized Medicine in Osteosarcoma: Pharmacogenetics as Predictive Marker of Outcome after Chemotherapy-Based Treatment

Author: Dunja M.W.M te Loo, Henk-Jan Guchelaar, Peter M. Hoogerbrugge, Frank N. van Leeuwen, Uta Flucke, H.W. Bart Schreuder, Winette T.A. van der Graaf, Eveline S.J.M. de Bont, Hanneke I. Vos, Remco R. Makkinje, Hans Gelderblom, Marieke J.H. Coenen, and Melanie M. Hagleitner
Abstract: Supplementary Table 3. Genetic variants associated with 5-year PFS
Published: 2023

28. Supplementary Table 2 from A First Step toward Personalized Medicine in Osteosarcoma: Pharmacogenetics as Predictive Marker of Outcome after Chemotherapy-Based Treatment

Author: Dunja M.W.M te Loo, Henk-Jan Guchelaar, Peter M. Hoogerbrugge, Frank N. van Leeuwen, Uta Flucke, H.W. Bart Schreuder, Winette T.A. van der Graaf, Eveline S.J.M. de Bont, Hanneke I. Vos, Remco R. Makkinje, Hans Gelderblom, Marieke J.H. Coenen, and Melanie M. Hagleitner
Abstract: Supplementary Table 2. Genetic variants associated with histologic response
Published: 2023

29. Data from A First Step toward Personalized Medicine in Osteosarcoma: Pharmacogenetics as Predictive Marker of Outcome after Chemotherapy-Based Treatment

Author: Dunja M.W.M te Loo, Henk-Jan Guchelaar, Peter M. Hoogerbrugge, Frank N. van Leeuwen, Uta Flucke, H.W. Bart Schreuder, Winette T.A. van der Graaf, Eveline S.J.M. de Bont, Hanneke I. Vos, Remco R. Makkinje, Hans Gelderblom, Marieke J.H. Coenen, and Melanie M. Hagleitner
Abstract: Purpose: Overall survival in patients with osteosarcoma is only 60%. Poor response to chemotherapy is the dominant risk factor for poor survival. Pharmacogenetic research can offer possibilities to optimize treatment and improve outcome. We applied a pathway-based approach to evaluate the cumulative effect of genes involved in the metabolism of cisplatin and doxorubicin in relationship to clinical outcome.Experimental Design: We included 126 patients with osteosarcoma. To comprehensively assess common genetic variation in the 54 genes selected, linkage disequilibrium (LD; r2 = 0.8)–based tag-single nucleotide polymorphisms (SNP) strategy was used. A final set of 384 SNPs was typed using Illumina Beadarray platform. SNPs significantly associated with 5-year progression-free survival (PFS) were replicated in another 64 patients with osteosarcoma.Results: We identified five variants in FasL, MSH2, ABCC5, CASP3, and CYP3A4 that were associated with 5-year PFS. Risk stratification based on the combined effects of the risk alleles showed a significant improvement of 5-year PFS. Patients that carried no or only one risk allele had a 5-year PFS of 100% compared with a 5-year PFS of 84.4% for carriers of two or three risk alleles, 66.7% PFS if a patient carried four to five alleles, and a 5-year PFS of 41.8% for patients with >5 risk alleles (P < 0.001).Conclusions: We identified several genes that showed association with PFS in patients with osteosarcoma. These pharmacogenetic risk factors might be useful to predict treatment outcome and to stratify patients immediately after diagnosis and offer the possibility to improve treatment and outcome. Clin Cancer Res; 21(15); 3436–41. ©2015 AACR.
Published: 2023

30. Supplementary Table 1 from A First Step toward Personalized Medicine in Osteosarcoma: Pharmacogenetics as Predictive Marker of Outcome after Chemotherapy-Based Treatment

Author: Dunja M.W.M te Loo, Henk-Jan Guchelaar, Peter M. Hoogerbrugge, Frank N. van Leeuwen, Uta Flucke, H.W. Bart Schreuder, Winette T.A. van der Graaf, Eveline S.J.M. de Bont, Hanneke I. Vos, Remco R. Makkinje, Hans Gelderblom, Marieke J.H. Coenen, and Melanie M. Hagleitner
Abstract: Supplementary Table 1. Set of 381 SNPs
Published: 2023

31. Computing and Detector Simulation Framework for the HIBEAM/NNBAR Experimental Program at the ESS

Author: Barrow Joshua, Brooijmans Gustaaf, Damian José Ignacio Marquez, DiJulio Douglas, Dunne Katherine, Golubeva Elena, Kamyshkov Yuri, Kittelmann Thomas, Klinkby Esben, Kókai Zsófi, Makkinje Jan, Meirose Bernhard, Milstead David, Nepomuceno André, Oskarsson Anders, Ramic Kemal, Rizzi Nicola, Santoro Valentina, Silverstein Samuel, Takibayev Alan, Wagner Richard, Yiu Sze-Chun, Zanini Luca, and Zimmer Oliver
Subjects: Physics, QC1-999
Abstract: The HIBEAM/NNBAR program is a proposed two-stage experiment at the European Spallation Source focusing on searches for baryon number violation via processes in which neutrons convert to antineutrons. This paper outlines the computing and detector simulation framework for the HIBEAM/NNBAR program. The simulation is based on predictions of neutron flux and neutronics together with signal and background generation. A range of diverse simulation packages are incorporated, including Monte Carlo transport codes, neutron ray-tracing simulation packages, and detector simulation software. The common simulation package in which these elements are interfaced together is discussed. Data management plans and triggers are also described.
Published: 2021
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32. A systems study reveals concurrent activation of AMPK and mTOR by amino acids

Author: Piero Dalle Pezze, Stefanie Ruf, Annika G. Sonntag, Miriam Langelaar-Makkinje, Philip Hall, Alexander M. Heberle, Patricia Razquin Navas, Karen van Eunen, Regine C. Tölle, Jennifer J. Schwarz, Heike Wiese, Bettina Warscheid, Jana Deitersen, Björn Stork, Erik Fäßler, Sascha Schäuble, Udo Hahn, Peter Horvatovich, Daryl P. Shanley, and Kathrin Thedieck
Subjects: Science
Abstract: mTORC1 is known to mediate the signalling activity of amino acids. Here, the authors combine modelling with experiments and find that amino acids acutely stimulate mTORC2, IRS/PI3K and AMPK, independently of mTORC1. AMPK activation through CaMKKβ sustains autophagy under non-starvation conditions.
Published: 2016
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33. Consequences of Mrp2 deficiency for diclofenac toxicity in the rat intestine ex vivo

Author: Niu, Xiaoyu, de Graaf, Inge A.M., van de Vegte, Dennis, Langelaar-Makkinje, Miriam, Sekine, Shuichi, and Groothuis, Geny M.M.
Published: 2015
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34. Butyrate oxidation attenuates the butyrate-induced improvement of insulin sensitivity in myotubes

Author: Melany Rios-Morales, Marcel A. Vieira-Lara, Esther Homan, Miriam Langelaar-Makkinje, Albert Gerding, Zhuang Li, Nicolette Huijkman, Patrick C.N. Rensen, Justina C. Wolters, Dirk-Jan Reijngoud, Barbara M. Bakker, Molecular Cell Physiology, AIMMS, and Center for Liver, Digestive and Metabolic Diseases (CLDM)
Subjects: Dietary Fiber, DIET-INDUCED OBESITY, Muscle Fibers, Skeletal, METABOLIC PATHWAYS, Insulins, Palmitates, Skeletal muscle, SODIUM-BUTYRATE, MOUSE, Histone Deacetylases, Histones, Mitochondrial Proteins, Humans, Coenzyme A, RNA, Messenger, Molecular Biology, IN-VIVO, Fatty Acids, Butyrate, Insulin resistance, Receptor, Insulin, Butyrates, CHAIN FATTY-ACIDS, Diabetes Mellitus, Type 2, CELLS, Fatty-acid oxidation, Molecular Medicine, SKELETAL-MUSCLE, PROTEOMICS, Glycolysis, RESISTANCE
Abstract: Skeletal muscle insulin resistance is a key pathophysiological process that precedes the development of type 2 diabetes. Whereas an overload of long-chain fatty acids can induce muscle insulin resistance, butyrate, a short -chain fatty acid (SCFA) produced from dietary fibre fermentation, prevents it. This preventive role of butyrate has been attributed to histone deacetylase (HDAC)-mediated transcription regulation and activation of mito-chondrial fatty-acid oxidation. Here we address the interplay between butyrate and the long-chain fatty acid palmitate and investigate how transcription, signalling and metabolism are integrated to result in the butyrate -induced skeletal muscle metabolism remodelling. Butyrate enhanced insulin sensitivity in palmitate-treated, insulin-resistant C2C12 cells, as shown by elevated insulin receptor 1 (IRS1) and pAKT protein levels and Slc2a4 (GLUT4) mRNA, which led to a higher glycolytic capacity. Long-chain fatty-acid oxidation capacity and other functional respiration parameters were not affected. Butyrate did upregulate mitochondrial proteins involved in its own oxidation, as well as concentrations of butyrylcarnitine and hydroyxybutyrylcarnitine. By knocking down the gene encoding medium-chain 3-ketoacyl-CoA thiolase (MCKAT, Acaa2), butyrate oxidation was inhibited, which amplified the effects of the SCFA on insulin sensitivity and glycolysis. This response was associated with enhanced HDAC inhibition, based on histone 3 acetylation levels. Butyrate enhances insulin sensitivity and induces glycolysis, without the requirement of upregulated long-chain fatty acid oxidation. Butyrate catabolism functions as an escape valve that attenuates HDAC inhibition. Thus, inhibition of butyrate oxidation indirectly prevents insulin resistance and stimulates glycolytic flux in myotubes treated with butyrate, most likely via an HDAC-dependent mechanism.
Published: 2022

35. Organoids as a model to study intestinal and liver dysfunction in severe malnutrition

Author: José M. Horcas-Nieto, Christian J. Versloot, Miriam Langelaar-Makkinje, Albert Gerding, Tjasso Blokzijl, Mirjam H. Koster, Mirjam Baanstra, Ingrid A. Martini, Robert P. Coppes, Céline Bourdon, Sven C.D. van Ijzendoorn, Peter Kim, Robert H.J. Bandsma, Barbara M. Bakker, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), and Center for Liver, Digestive and Metabolic Diseases (CLDM)
Subjects: Organoids, Malnutrition, Peroxisomes, Molecular Medicine, Amino acids, Molecular Biology, Mitochondria
Abstract: Hospitalized children with severe malnutrition face high mortality rates and often suffer from hepatic and intestinal dysfunction, with negative impacts on their survival. New treatments cannot be developed without understanding the underlying pathophysiology. We have established and characterized translational organoid models of severe malnutrition of the liver and the intestine. In these models, amino acid starvation recapitulates the expected organ-specific functional changes (e.g., hepatic steatosis, barrier dysfunction) accompanied by reduced mitochondrial and peroxisomal proteins, and altered intestinal tight junction proteins. Re-supplementation of amino acids or pharmacological interventions with rapamycin or fenofibrate lead to partial recovery. Restoration of protein levels aligned with signs of improved peroxisomal function in both organoids, and increased mitochondrial proteins and tight junction protein claudin-3 in intestinal organoids. We present two organoid models as novel tools to gain mechanistic insights and to act as a testing platform for potential treatments for intestinal and hepatic dysfunction in severe malnutrition.
Published: 2022

36. Shared and unique genetic contributions to attention deficit/hyperactivity disorder and substance use disorders: A pilot study of six candidate genes

Author: Carpentier, P.J., Arias Vasquez, A., Hoogman, M., Onnink, M., Kan, C.C., Kooij, J.J.S., Makkinje, R., Iskandar, S., Kiemeney, L.A., de Jong, C.A.J., Franke, B., and Buitelaar, J.K.
Published: 2013
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37. T-cell Abca1 and Abcg1 cholesterol efflux pathways suppress T-cell apoptosis and senescence and increase atherosclerosis in middle-agedLdlr-/-mice

Author: Venetia Bazioti, Anouk M. La Rose, Sjors Maassen, Frans Bianchi, Rinse de Boer, Emma Guilbaud, Arthur Flohr-Svendsen, Anouk G. Groenen, Alejandro Marmolejo-Garza, Mirjam H. Koster, Niels J. Kloosterhuis, Alle T. Pranger, Miriam Langelaar-Makkinje, Alain de Bruin, Bart van de Sluis, Alison B. Kohan, Laurent Yvan-Charvet, Geert van den Bogaart, and Marit Westerterp
Subjects: lipids (amino acids, peptides, and proteins)
Abstract: Atherosclerosis is a chronic inflammatory disease driven by hypercholesterolemia. During aging, T-cells accumulate cholesterol, which could lead to a pro-inflammatory phenotype. However, the role of cholesterol efflux pathways mediated by ATP-binding cassette A1 and G1 (ABCA1/ABCG1) in T-cell-dependent age-related inflammation and atherosclerosis remains poorly understood. In this study, we generated mice with T-cell-specificAbca1/Abcg1-deficiency on the low-density-lipoprotein-receptor deficient (Ldlr-/-) background. T-cellAbca1/Abcg1-deficiency decreased blood, lymph node, and splenic T-cells, and increased T-cell activation and apoptosis. T-cellAbca1/Abcg1-deficiency induced a premature T-cell aging phenotype in middle-aged (12-13 months)Ldlr-/-mice, reflected by upregulation of senescence markers. Despite T-cell senescence and enhanced T-cell activation, T-cellAbca1/Abcg1-deficiency decreased atherosclerosis and aortic inflammation in middle-agedLdlr-/-mice, accompanied by decreased T-cells in atherosclerotic plaques. We attribute these effects to T-cell apoptosis downstream of T-cell activation. Collectively, T-cell cholesterol efflux pathways are critical for maintaining T-cell numbers, suppress senescence, and induce atherosclerosis in middle-agedLdlr-/-mice.
Published: 2022

38. T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice

Author: LS Pathobiologie, Dep Biomolecular Health Sciences, Pathobiologie, dPB RMSC, Bazioti, Venetia, La Rose, Anouk M, Maassen, Sjors, Bianchi, Frans, de Boer, Rinse, Halmos, Benedek, Dabral, Deepti, Guilbaud, Emma, Flohr-Svendsen, Arthur, Groenen, Anouk G, Marmolejo-Garza, Alejandro, Koster, Mirjam H, Kloosterhuis, Niels J, Havinga, Rick, Pranger, Alle T, Langelaar-Makkinje, Miriam, de Bruin, Alain, van de Sluis, Bart, Kohan, Alison B, Yvan-Charvet, Laurent, van den Bogaart, Geert, Westerterp, Marit, LS Pathobiologie, Dep Biomolecular Health Sciences, Pathobiologie, dPB RMSC, Bazioti, Venetia, La Rose, Anouk M, Maassen, Sjors, Bianchi, Frans, de Boer, Rinse, Halmos, Benedek, Dabral, Deepti, Guilbaud, Emma, Flohr-Svendsen, Arthur, Groenen, Anouk G, Marmolejo-Garza, Alejandro, Koster, Mirjam H, Kloosterhuis, Niels J, Havinga, Rick, Pranger, Alle T, Langelaar-Makkinje, Miriam, de Bruin, Alain, van de Sluis, Bart, Kohan, Alison B, Yvan-Charvet, Laurent, van den Bogaart, Geert, and Westerterp, Marit
Published: 2022

39. Sjuksköterskors erfarenheter avseende patienter som avlider under sjukhusvård : Litteraturöversikt

Author: Makkinje, Therese, Karlström, Ida, Makkinje, Therese, and Karlström, Ida
Abstract: Bakgrund: Även om döden är en del av livet, så är det är svårt för människor att förstå och acceptera döden. De som lämnar livet borde få samma uppmärksamhet och kärleksfulla vård som de som träder in i det. Det är en central uppgift för sjuksköterskor att ta hand om omvårdnaden med ett personcentrerat förhållningssätt medan sjukhusvårdens huvuduppdrag är att behandla. För en god och säker hälso- och sjukvård behöver sjuksköterskan ingå i ett team med olika kompetenser som kompletterar varandra, där sjuksköterskans uppgift är att ansvara för omvårdnadskompetensen och informationsöverföringen. Vid dödsfall ska sjuksköterskan assistera läkaren vid konstaterandet och har ansvaret för att iordningställa patienten efter anhörigas önskemål. Syfte: Syftet var att beskriva sjuksköterskors erfarenheter avseende patienter som avlider under sjukhusvård. Metod: Litteraturstudien var baserad på analysen av nio kvalitativa vetenskapliga artiklar, som var hämtade från databaserna CINAHL och PsycInfo. Studierna kvalitetsgranskades med hjälp av Malmö Högskolas mall för kvalitetsgranskning av vetenskapliga artiklar. Studierna var publicerade från 2015 och framåt. Resultat: Resultatet visade att sjuksköterskor påverkades av dödsfall både personligt och yrkesmässigt. För att hantera känslor efteråt beskrevs även att stöd efter dessa upplevelser var viktigt. Kategorier arbetsplatsens påverkan, känslomässig påverkan, copingstrategier, utbildning och reflektioner om döden skapades för att de beskrev sjuksköterskornas erfarenheter avseende patienter som avlidit. Slutsats: Sjuksköterskor kan bli känslomässigt påverkade av patienter som avlider. I dessa situationer var det viktigt att få stöd från arbetsplatsen.
Published: 2022

40. Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites

Author: Niu, Xiaoyu, de Graaf, Inge A. M., Langelaar-Makkinje, Miriam, Horvatovich, Peter, and Groothuis, Geny M. M.
Published: 2015
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41. T-cell Abca1 and Abcg1 cholesterol efflux pathways suppress T-cell apoptosis and senescence and increase atherosclerosis in middle-agedLdlr-/-mice

Author: Bazioti, Venetia, primary, La Rose, Anouk M., additional, Maassen, Sjors, additional, Bianchi, Frans, additional, de Boer, Rinse, additional, Guilbaud, Emma, additional, Flohr-Svendsen, Arthur, additional, Groenen, Anouk G., additional, Marmolejo-Garza, Alejandro, additional, Koster, Mirjam H., additional, Kloosterhuis, Niels J., additional, Pranger, Alle T., additional, Langelaar-Makkinje, Miriam, additional, de Bruin, Alain, additional, van de Sluis, Bart, additional, Kohan, Alison B., additional, Yvan-Charvet, Laurent, additional, van den Bogaart, Geert, additional, and Westerterp, Marit, additional
Published: 2022
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42. New high-sensitivity searches for neutrons converting into antineutrons and/or sterile neutrons at the HIBEAM/NNBAR experiment at the European Spallation Source

Author: Addazi, A, primary, Anderson, K, additional, Ansell, S, additional, Babu, K S, additional, Barrow, J L, additional, Baxter, D V, additional, Bentley, P M, additional, Berezhiani, Z, additional, Bevilacqua, R, additional, Biondi, R, additional, Bohm, C, additional, Brooijmans, G, additional, Broussard, L J, additional, Cedercäll, J, additional, Crawford, C, additional, Dev, P S B, additional, DiJulio, D D, additional, Dolgov, A D, additional, Dunne, K, additional, Fierlinger, P, additional, Fitzsimmons, M R, additional, Fomin, A, additional, Frost, M J, additional, Gardiner, S, additional, Gardner, S, additional, Galindo-Uribarri, A, additional, Geltenbort, P, additional, Girmohanta, S, additional, Golubev, P, additional, Golubeva, E, additional, Greene, G L, additional, Greenshaw, T, additional, Gudkov, V, additional, Hall-Wilton, R, additional, Heilbronn, L, additional, Herrero-Garcia, J, additional, Holley, A, additional, Ichikawa, G, additional, Ito, T M, additional, Iverson, E, additional, Johansson, T, additional, Jönsson, L, additional, Jwa, Y-J, additional, Kamyshkov, Y, additional, Kanaki, K, additional, Kearns, E, additional, Kokai, Z, additional, Kerbikov, B, additional, Kitaguchi, M, additional, Kittelmann, T, additional, Klinkby, E, additional, Kobakhidze, A, additional, Koerner, L W, additional, Kopeliovich, B, additional, Kozela, A, additional, Kudryavtsev, V, additional, Kupsc, A, additional, Lee, Y T, additional, Lindroos, M, additional, Makkinje, J, additional, Marquez, J I, additional, Meirose, B, additional, Miller, T M, additional, Milstead, D, additional, Mohapatra, R N, additional, Morishima, T, additional, Muhrer, G, additional, Mumm, H P, additional, Nagamoto, K, additional, Nepomuceno, A, additional, Nesti, F, additional, Nesvizhevsky, V V, additional, Nilsson, T, additional, Oskarsson, A, additional, Paryev, E, additional, Pattie, R W, additional, Penttil, S, additional, Perrey, H, additional, Pokotilovski, Y N, additional, Potashnikovav, I, additional, Ramic, K, additional, Redding, C, additional, Richard, J-M, additional, Ries, D, additional, Rinaldi, E, additional, Rizzi, N, additional, Rossi, N, additional, Ruggles, A, additional, Rybolt, B, additional, Santoro, V, additional, Sarkar, U, additional, Saunders, A, additional, Senjanovic, G, additional, Serebrov, A P, additional, Shimizu, H M, additional, Shrock, R, additional, Silverstein, S, additional, Silvermyr, D, additional, Snow, W M, additional, Takibayev, A, additional, Tkachev, I, additional, Townsend, L, additional, Tureanu, A, additional, Varriano, L, additional, Vainshtein, A, additional, de Vries, J, additional, Wagner, R, additional, Woracek, R, additional, Yamagata, Y, additional, Yiu, S, additional, Young, A R, additional, Zanini, L, additional, Zhang, Z, additional, and Zimmer, O, additional
Published: 2021
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43. New high-sensitivity searches for neutrons converting into antineutrons and/or sterile neutrons at the HIBEAM/NNBAR experiment at the European Spallation Source

Author: J. I. Marquez, E. Golubeva, Zurab Berezhiani, B. Z. Kopeliovich, K. Dunne, M. Lindroos, L. Townsend, Takeyasu M. Ito, Agneta Oskarsson, A. Kozela, David Milstead, Samuel Silverstein, D. D. DiJulio, S. Yiu, A. D. Dolgov, Lawrence Heilbronn, P. Fierlinger, A. Tureanu, Christian Bohm, G. Ichikawa, B. Rybolt, E. B. Klinkby, Igor Tkachev, Arkady Vainshtein, Y. N. Pokotilovski, Archil Kobakhidze, Kevin W. Anderson, R. W. Pattie, Y. J. Jwa, Leah Broussard, R. Biondi, B. Kerbikov, David V. Baxter, J. Cedercäll, David Olle Rickard Silvermyr, A. Holley, A. Addazi, A. P. Serebrov, Hans P. Mumm, S. Girmohanta, V. Santoro, Arthur E. Ruggles, P. Geltenbort, Yuri Kamyshkov, H. M. Shimizu, Geoffrey Greene, N. Rizzi, Joshua Barrow, A. Takibayev, Christopher Crawford, T. Greenshaw, N. Rossi, E. Paryev, Thomas Nilsson, A. A. Nepomuceno, Robert Shrock, L. W. Koerner, R. Woracek, T. Johansson, S. Gardiner, L. Varriano, G. Muhrer, Susan Gardner, A. Kupsc, J. M. Richard, Bernhard Meirose, R. Hall-Wilton, Vladimir Gudkov, T. Morishima, J. Makkinje, E. Rinaldi, J. Herrero-Garcia, Michael R. Fitzsimmons, P. S. B. Dev, Y. T. Lee, Erik B. Iverson, K. S. Babu, Y. Yamagata, C. Redding, H. Perrey, Rabindra N. Mohapatra, Albert Young, V. V. Nesvizhevsky, Masaaki Kitaguchi, S. Penttil, G. Brooijmans, Fabrizio Nesti, J. de Vries, Riccardo Bevilacqua, O. Zimmer, Kalliopi Kanaki, Robert Wagner, K. Ramic, E. Kearns, Z. Zhang, K. Nagamoto, L. Zanini, S. Ansell, P. M. Bentley, T. Kittelmann, A. Fomin, T. M. Miller, U. Sarkar, Goran Senjanovic, A. Galindo-Uribarri, W. M. Snow, Pavel Golubev, V. A. Kudryavtsev, M. J. Frost, Z. Kokai, A. Saunders, L. Jönsson, D. Ries, I. Potashnikovav, Institut Laue-Langevin (ILL), ILL, Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), and Department of Physics
Subjects: baryon number violation, feebly interacting particles, European Spallation Source, baryogenesis, Physics beyond the Standard Model, Nuclear Theory, EXPERIMENTAL LIMIT, Antineutron, 01 natural sciences, Subatomär fysik, ANTIPROTON ANNIHILATION, n: oscillation, Subatomic Physics, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Nuclear Experiment, sterile, Physics, MIRROR MATTER, new physics, anti-n, ddc, Antimatter, baryon: asymmetry, proposed experiment, DAMA ANNUAL MODULATION, Nuclear and High Energy Physics, Particle physics, Accelerator Physics and Instrumentation, 114 Physical sciences, Baryon asymmetry, nuclear physics, 0103 physical sciences, DARK-MATTER, mixing, Neutron, Sensitivity (control systems), [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], TRANSITION OPERATORS, 010306 general physics, baryon number: violation, activity report, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Acceleratorfysik och instrumentering, MAJORANA NEUTRINOS, sensitivity, Baryogenesis, regeneration, UNIFIED PICTURE, B-L SYMMETRY, Baryon number, BARYON-NUMBER NONCONSERVATION
Abstract: The violation of baryon number, B , is an essential ingredient for the preferential creation of matter over antimatter needed to account for the observed baryon asymmetry in the Universe. However, such a process has yet to be experimentally observed. The HIBEAM/NNBAR program is a proposed two-stage experiment at the European Spallation Source to search for baryon number violation. The program will include high-sensitivity searches for processes that violate baryon number by one or two units: free neutron–antineutron oscillation ( n → n ̄ ) via mixing, neutron–antineutron oscillation via regeneration from a sterile neutron state ( n → [ n ′ , n ̄ ′ ] → n ̄ ), and neutron disappearance (n → n′); the effective Δ B = 0 process of neutron regeneration ( n → [ n ′ , n ̄ ′ ] → n ) is also possible. The program can be used to discover and characterize mixing in the neutron, antineutron and sterile neutron sectors. The experiment addresses topical open questions such as the origins of baryogenesis and the nature of dark matter, and is sensitive to scales of new physics substantially in excess of those available at colliders. A goal of the program is to open a discovery window to neutron conversion probabilities (sensitivities) by up to three orders of magnitude compared with previous searches. The opportunity to make such a leap in sensitivity tests should not be squandered. The experiment pulls together a diverse international team of physicists from the particle (collider and low energy) and nuclear physics communities, while also including specialists in neutronics and magnetics.
Published: 2021

44. A Computing and Detector Simulation Framework for the HIBEAM/NNBAR Experimental Program at the ESS

Author: Katherine Dunne, Samuel Silverstein, Valentina Santoro, Yuri Kamyshkov, E. B. Klinkby, Jan Makkinje, Oliver Zimmer, A. A. Nepomuceno, Thomas Kittelmann, Joshua Barrow, A. Takibayev, Kemal Ramic, Douglas D. DiJulio, Sze-Chun Yiu, L. Zanini, Jose Ignacio Marquez Damian, Bernhard Meirose, Elena Golubeva, Zsófi Kókai, Gustaaf Brooijmans, David Milstead, Anders Nils Erik Oskarsson, Richard E. Wagner, Nicola Rizzi, Institut Laue-Langevin (ILL), and ILL
Subjects: Neutron transport, Physics - Instrumentation and Detectors, Computer science, Data management, QC1-999, Astrophysics::High Energy Astrophysical Phenomena, Monte Carlo method, FOS: Physical sciences, computer.software_genre, 01 natural sciences, Computational science, Neutron flux, 0103 physical sciences, Neutron, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Nuclear Experiment, 010308 nuclear & particles physics, business.industry, Physics, SIGNAL (programming language), Detector, Instrumentation and Detectors (physics.ins-det), Simulation software, business, computer
Abstract: The HIBEAM/NNBAR program is a proposed two-stage experiment at the European Spallation Source focusing on searches for baryon number violation via processes in which neutrons convert to antineutrons. This paper outlines the computing and detector simulation framework for the HIBEAM/NNBAR program. The simulation is based on predictions of neutron flux and neutronics together with signal and background generation. A range of diverse simulation packages are incorporated, including Monte Carlo transport codes, neutron ray-tracing simulation packages, and detector simulation software. The common simulation package in which these elements are interfaced together is discussed. Data management plans and triggers are also described., Comment: Contribution to CHEP2021. Accepted for publication in the European Physical Journal (EPJ) Web of Conferences
Published: 2021
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45. New high-sensitivity searches for neutrons converting into antineutrons and/or sterile neutrons at the HIBEAM/NNBAR experiment at the European Spallation Source

Author: Addazi, A., Anderson, K., Ansell, S., Babu, K. S., Barrow, J. L., Baxter, D. V., Bentley, P. M., Berezhiani, Z., Bevilacqua, R., Biondi, R., Bohm, C., Brooijmans, G., Broussard, L. J., Cedercäll, J., Crawford, C., Dev, P. S. B., DiJulio, D. D., Dolgov, A. D., Dunne, K., Fierlinger, P., Fitzsimmons, M. R., Fomin, A., Frost, M. J., Gardiner, S., Gardner, S., Galindo-Uribarri, A., Geltenbort, P., Girmohanta, S., Golubev, P., Golubeva, E., Greene, G. L., Greenshaw, T., Gudkov, V., Hall-Wilton, R., Heilbronn, L., Herrero-Garcia, J., Holley, A., Ichikawa, G., Ito, T. M., Iverson, E., Johansson, Tord, Jönsson, L., Jwa, Y-J, Kamyshkov, Y., Kanaki, K., Kearns, E., Kokai, Z., Kerbikov, B., Kitaguchi, M., Kittelmann, T., Klinkby, E., Kobakhidze, A., Koerner, L. W., Kopeliovich, B., Kozela, A., Kudryavtsev, V., Kupsc, A., Lee, Y. T., Lindroos, M., Makkinje, J., Marquez, J. I., Meirose, B., Miller, T. M., Milstead, D., Mohapatra, R. N., Morishima, T., Muhrer, G., Mumm, H. P., Nagamoto, K., Nepomuceno, A., Nesti, F., Nesvizhevsky, V. V., Nilsson, T., Oskarsson, A., Paryev, E., Pattie Jr., R. W., Penttil, S., Perrey, H., Pokotilovski, Y. N., Potashnikovav, I., Ramic, K., Redding, C., Richard, J-M, Ries, D., Rinaldi, E., Rizzi, N., Rossi, N., Ruggles, A., Rybolt, B., Santoro, V., Sarkar, U., Saunders, A., Senjanovic, G., Serebrov, A. P., Shimizu, H. M., Shrock, R., Silverstein, S., Silvermyr, D., Snow, W. M., Takibayev, A., Tkachev, I., Townsend, L., Tureanu, A., Varriano, L., Vainshtein, A., de Vries, J., Wagner, R., Woracek, R., Yamagata, Y., Yiu, S., Young, A. R., Zanini, L., Zhang, Z., Zimmer, O., Addazi, A., Anderson, K., Ansell, S., Babu, K. S., Barrow, J. L., Baxter, D. V., Bentley, P. M., Berezhiani, Z., Bevilacqua, R., Biondi, R., Bohm, C., Brooijmans, G., Broussard, L. J., Cedercäll, J., Crawford, C., Dev, P. S. B., DiJulio, D. D., Dolgov, A. D., Dunne, K., Fierlinger, P., Fitzsimmons, M. R., Fomin, A., Frost, M. J., Gardiner, S., Gardner, S., Galindo-Uribarri, A., Geltenbort, P., Girmohanta, S., Golubev, P., Golubeva, E., Greene, G. L., Greenshaw, T., Gudkov, V., Hall-Wilton, R., Heilbronn, L., Herrero-Garcia, J., Holley, A., Ichikawa, G., Ito, T. M., Iverson, E., Johansson, Tord, Jönsson, L., Jwa, Y-J, Kamyshkov, Y., Kanaki, K., Kearns, E., Kokai, Z., Kerbikov, B., Kitaguchi, M., Kittelmann, T., Klinkby, E., Kobakhidze, A., Koerner, L. W., Kopeliovich, B., Kozela, A., Kudryavtsev, V., Kupsc, A., Lee, Y. T., Lindroos, M., Makkinje, J., Marquez, J. I., Meirose, B., Miller, T. M., Milstead, D., Mohapatra, R. N., Morishima, T., Muhrer, G., Mumm, H. P., Nagamoto, K., Nepomuceno, A., Nesti, F., Nesvizhevsky, V. V., Nilsson, T., Oskarsson, A., Paryev, E., Pattie Jr., R. W., Penttil, S., Perrey, H., Pokotilovski, Y. N., Potashnikovav, I., Ramic, K., Redding, C., Richard, J-M, Ries, D., Rinaldi, E., Rizzi, N., Rossi, N., Ruggles, A., Rybolt, B., Santoro, V., Sarkar, U., Saunders, A., Senjanovic, G., Serebrov, A. P., Shimizu, H. M., Shrock, R., Silverstein, S., Silvermyr, D., Snow, W. M., Takibayev, A., Tkachev, I., Townsend, L., Tureanu, A., Varriano, L., Vainshtein, A., de Vries, J., Wagner, R., Woracek, R., Yamagata, Y., Yiu, S., Young, A. R., Zanini, L., Zhang, Z., and Zimmer, O.
Abstract: The violation of baryon number, , is an essential ingredient for the preferential creation of matter over antimatter needed to account for the observed baryon asymmetry in the Universe. However, such a process has yet to be experimentally observed. The HIBEAM/NNBAR program is a proposed two-stage experiment at the European Spallation Source to search for baryon number violation. The program will include high-sensitivity searches for processes that violate baryon number by one or two units: free neutron–antineutron oscillation () via mixing, neutron–antineutron oscillation via regeneration from a sterile neutron state (), and neutron disappearance (n → n'); the effective process of neutron regeneration () is also possible. The program can be used to discover and characterize mixing in the neutron, antineutron and sterile neutron sectors. The experiment addre
Published: 2021
Full Text: View/download PDF

46. Computing and Detector Simulation Framework for the HIBEAM/NNBAR Experimental Program at the ESS

Author: Barrow, Joshua, Brooijmans, Gustaaf, Damian, José Ignacio Marquez, DiJulio, Douglas, Dunne, Katherine, Golubeva, Elena, Kamyshkov, Yuri, Kittelmann, Thomas, Klinkby, Esben, Kókai, Zsófi, Makkinje, Jan, Meirose, Bernhard, Milstead, David, Nepomuceno, André, Oskarsson, Anders, Ramic, Kemal, Rizzi, Nicola, Santoro, Valentina, Silverstein, Samuel, Takibayev, Alan, Wagner, Richard, Yiu, Sze-Chun, Zanini, Luca, Zimmer, Oliver, Barrow, Joshua, Brooijmans, Gustaaf, Damian, José Ignacio Marquez, DiJulio, Douglas, Dunne, Katherine, Golubeva, Elena, Kamyshkov, Yuri, Kittelmann, Thomas, Klinkby, Esben, Kókai, Zsófi, Makkinje, Jan, Meirose, Bernhard, Milstead, David, Nepomuceno, André, Oskarsson, Anders, Ramic, Kemal, Rizzi, Nicola, Santoro, Valentina, Silverstein, Samuel, Takibayev, Alan, Wagner, Richard, Yiu, Sze-Chun, Zanini, Luca, and Zimmer, Oliver
Abstract: The HIBEAM/NNBAR program is a proposed two-stage experiment at the European Spallation Source focusing on searches for baryon number violation via processes in which neutrons convert to antineutrons. This paper outlines the computing and detector simulation framework for the HIBEAM/NNBAR program. The simulation is based on predictions of neutron flux and neutronics together with signal and background generation. A range of diverse simulation packages are incorporated, including Monte Carlo transport codes, neutron ray-tracing simulation packages, and detector simulation software. The common simulation package in which these elements are interfaced together is discussed. Data management plans and triggers are also described.
Published: 2021
Full Text: View/download PDF

47. Plant adaptogens increase lifespan and stress resistance in C. elegans

Author: Wiegant, F. A. C., Surinova, S., Ytsma, E., Langelaar-Makkinje, M., Wikman, G., and Post, J. A.
Published: 2009
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48. The LUX-ZEPLIN (LZ) radioactivity and cleanliness control programs

Author: Mikkel B. Johnson, B. Landerud, A. Biekert, B. N. Edwards, K. Hanzel, T. E. Tope, D. Curran, C. Chiller, J. Palmer, R. Leonard, P. Sutcliffe, E. D. Fraser, R. Bunker, J. So, A. A. Chiller, M. R. While, A. Dobi, D. Hamilton, M. G. D. van der Grinten, W. J. Wisniewski, J. Li, A. Fan, J.S. Saba, C. Lynch, Henrique Araujo, S. Luitz, J. Nesbit, M. Horn, C. D. Kocher, Catarina Silva, F. G. O’Neill, J. C. Davis, J. J. Silk, M. C. Carmona-Benitez, Simon Fayer, M. Pangilinan, K. O’Sullivan, D. Lucero, Q. Xiao, D. Hemer, B. Boxer, J. M. Lyle, C. Chan, C. E. Tull, J. Genovesi, A. Vaitkus, M. Arthurs, V. B. Francis, S. Kravitz, X. Liu, H. J. Birch, R. Linehan, S. Walcott, C. H. Faham, T. J. Anderson, A. B.M.R. Sazzad, D. White, A. Kamaha, M. S. Witherell, R. Studley, K. Sundarnath, R. Liu, H. Oh, L. Korley, H. Flaecher, R. Conley, K. Kamdin, P. Beltrame, S. Stephenson, C. Pereira, C. R. Hall, R. Cabrita, B. Holbrook, B. G. Lenardo, P. Majewski, T.M. Stiegler, I. B. Peterson, A. Manalaysay, A. Monte, C. Ghag, H. Kraus, C. Loniewski, J. Makkinje, X. Xiang, Robert A. Taylor, M. N. Irving, S. Uvarov, Michael Schubnell, J. Heise, R. Coughlen, A. Lambert, F. Froborg, L. Oxborough, D.C. Malling, S. Greenwood, J. Yin, S. J. Haselschwardt, H. J. Krebs, W. H. Lippincott, K. J. Palladino, R. E. Smith, V. A. Kudryavtsev, I. Olcina, C. M. Ignarra, A. Harrison, A. J. Bailey, Minfang Yeh, D. Bauer, W. Skulski, J. Keefner, O. Hitchcock, Ben Carlson, E. Leason, Benjamin Krikler, A. Cottle, E. Mizrachi, Michele Cascella, M. Khaleeq, M. Solmaz, T. J. Whitis, J. J. Wang, N. Angelides, S. Gokhale, K. Skarpaas, Daniel McKinsey, S. Dardin, S. Kyre, D. Santone, P. R. Scovell, T. Vietanen, S. Powell, Y. Wang, David Leonard, E. Morrison, N. Swanson, M. Sarychev, M. A. Olevitch, E. K. Pease, M. Elnimr, P. Brás, N.J. Gantos, R. G. Jacobsen, J. Migneault, Yeongduk Kim, W. Turner, S. D. Worm, Seth Hillbrand, T. Fruth, G. Gregerson, Wenzhao Wei, V. Kasey, L. Kreczko, J. R. Watson, A. Bhatti, D. Naim, Ethan Bernard, B. J. Mount, V. N. Solovov, C. Nedlik, K. Wilson, Elena Korolkova, G. R. C. Rischbieter, P. Ford, A. Stevens, D. J. Taylor, H. N. Nelson, F. Neves, S. Aviles, W. T. Emmet, K. Stifter, B. Birrittella, J. T. White, S. J. Patton, D. Molash, M. Severson, T. A. Shutt, A. Richards, D Kodroff, J. Lin, Kareem Kazkaz, T. P. Biesiadzinski, David Colling, J. Liao, J. Mock, J. A. Morad, E. Holtom, J. E. Y. Dobson, Bjoern Penning, C. E. Dahl, A. Dushkin, A. Konovalov, D. J. Markley, G. W. Shutt, N. Parveen, M. G. D. Gilchriese, Yanwen Liu, C. Carels, Martin Breidenbach, Kathrin C. Walker, V.V. Sosnovtsev, A. Naylor, K. T. Lesko, N. A. Larsen, C. Lee, A. Pagac, J. J. Cherwinka, N. Decheine, J. Bang, J. A. Nikoleyczik, Patrick Bauer, J.P. Rodrigues, S. Branson, T. J. R. Davison, B. Lopez Paredes, D. Pagenkopf, J. S. Campbell, M. Tan, K. C. Oliver-Mallory, M.J. Barry, J. Belle, D. Yu. Akimov, M. Timalsina, S. Shaw, Alexander Bolozdynya, W. Ji, Sridhara Dasu, D. Q. Huang, J. Edwards, F. L. H. Wolfs, K. E. Boast, J. Busenitz, Ren-Jie Wang, S. Fiorucci, N. Stern, C. Rhyne, V. Bugaev, A. Laundrie, G. Rutherford, G. Pereira, E. H. Miller, W. W. Craddock, S. Alsum, J.P. da Cunha, Richard J. Smith, A. Cole, W. Wang, Julie Harrison, I. Khurana, M. Utes, R. J. Gaitskell, J. Kras, D. Khaitan, R. L. Mannino, J. D. Wolfs, H. Auyeung, L. de Viveiros, E. Voirin, E. M. Boulton, N. I. Chott, I. Stancu, L. Tvrznikova, Richard Rosero, P. MarrLaundrie, D. R. Tronstad, T. Benson, Dongming Mei, T. J. Sumner, O. Jahangir, J. Va’vra, Ross G. White, L. Sabarots, A. Currie, A. R. Smith, W. L. Waldron, J. P. Coleman, E. Lopez-Asamar, Wolfgang Lorenzon, A. Piepke, Carl Gwilliam, S. Hans, T. Harrington, Laura Manenti, A. Greenall, F.-T. Liao, G. Cox, J. R. Bensinger, V. M. Gehman, H. J. Rose, Christopher Brew, X. Bai, P. Sorensen, A. Arbuckle, Y. Qie, R. C. Webb, R.M. Gerhard, T.W. Hurteau, K.J. Thomas, P. Rossiter, C. Hasselkus, W. G. Jones, J. Johnson, R. Gelfand, T. G. Gonda, C. O. Vuosalo, A. St. J. Murphy, Adam Bernstein, Chao Zhang, A. Nilima, R. M. Preece, T. K. Edberg, Q. Riffard, B. P. Tennyson, Yue Meng, C. Maupin, J. E. Cutter, J. Reichenbacher, J.Y-K. Hor, N. Marangou, D. Temples, Eli Gibson, M. Hoff, H. S. Lee, J. H. Buckley, Z. J. Minaker, M.I. Lopes, M. Koyuncu, P. A. Terman, J.R. Verbus, Bhawna Gomber, J. A. Nikkel, A. Alquahtani, I. M. Fogarty Florang, D. Seymour, A. V. Kumpan, Antonin Vacheret, C. Hjemfelt, M.R. Stark, S. Pierson, M. Racine, D. R. Tiedt, D. S. Akerib, A. Khazov, W. C. Taylor, J. Balajthy, A.V. Khromov, A. C. Kaboth, V. M. Palmaccio, Duncan Carlsmith, K. Pushkin, S. A. Hertel, S. N. Jeffery, E. Druszkiewicz, R. W. Schnee, S. Pal, R. Bramante, B. N. Ratcliff, M. E. Monzani, J. O'Dell, P. Zarzhitsky, L. Wang, P. Johnson, Matthew Szydagis, W. H. To, J. E. Armstrong, U. Utku, Mani Tripathi, D. Woodward, D. Garcia, W. R. Edwards, Carl W. Akerlof, Jilei Xu, C. Nehrkorn, Ian S. Young, J. McLaughlin, J. Thomson, S. R. Eriksen, R. Rucinski, T.J. Martin, C. Levy, Sergey Burdin, A. Baxter, A. Lindote, L. Reichhart, Juhyeong Lee, S. Balashov, C. T. McConnell, M. F. Marzioni, A. Tomás, W. T. Kim, S. Weatherly, and Science and Technology Facilities Council (STFC)
Subjects: BACKGROUNDS, Particle physics, Photomultiplier, Physics - Instrumentation and Detectors, Physics and Astronomy (miscellaneous), FOS: Physical sciences, lcsh:Astrophysics, Scintillator, 01 natural sciences, High Energy Physics - Experiment, Physics, Particles & Fields, High Energy Physics - Experiment (hep-ex), WIMP, lcsh:QB460-466, 0103 physical sciences, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, Gamma spectroscopy, Sensitivity (control systems), 010306 general physics, DETECTOR, physics.ins-det, 0206 Quantum Physics, Engineering (miscellaneous), Physics, Science & Technology, hep-ex, 010308 nuclear & particles physics, Scattering, IMPURITIES, Instrumentation and Detectors (physics.ins-det), Nuclear & Particles Physics, Physical Sciences, 0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics, Content (measure theory), lcsh:QC770-798, CONSTRUCTION MATERIALS
Abstract: LUX-ZEPLIN (LZ) is a second-generation direct dark matter experiment with spin-independent WIMP-nucleon scattering sensitivity above $1.4 \times 10^{-48}$ cm$^{2}$ for a WIMP mass of 40 GeV/c$^{2}$ and a 1000 d exposure. LZ achieves this sensitivity through a combination of a large 5.6 t fiducial volume, active inner and outer veto systems, and radio-pure construction using materials with inherently low radioactivity content. The LZ collaboration performed an extensive radioassay campaign over a period of six years to inform material selection for construction and provide an input to the experimental background model against which any possible signal excess may be evaluated. The campaign and its results are described in this paper. We present assays of dust and radon daughters depositing on the surface of components as well as cleanliness controls necessary to maintain background expectations through detector construction and assembly. Finally, examples from the campaign to highlight fixed contaminant radioassays for the LZ photomultiplier tubes, quality control and quality assurance procedures through fabrication, radon emanation measurements of major sub-systems, and bespoke detector systems to assay scintillator are presented., Comment: 45 pages (79 inc. tables), 7 figures, 9 tables
Published: 2020

49. Cleavable crosslinkers as tissue fixation reagents for proteomic analysis

Author: Sara Ongay, Hermen S. Overkleeft, Marcel P. Stoop, Geny M. M. Groothuis, Rainer Bischoff, Theo M. Luider, Miriam Langelaar-Makkinje, Nora Liu, Analytical Biochemistry, Nanomedicine & Drug Targeting, Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Medicinal Chemistry and Bioanalysis (MCB), and Neurology
Subjects: Proteomics, 0301 basic medicine, Tissue Fixation, Proteome, Succinimides, Biochemistry, Fixatives, 03 medical and health sciences, chemistry.chemical_compound, stomatognathic system, Tandem Mass Spectrometry, Protein purification, Journal Article, Animals, Peptide bond, Molecular Biology, Fixation (histology), chemistry.chemical_classification, Tissue Preservation, Periodic Acid, Organic Chemistry, Rats, Amino acid, Cross-Linking Reagents, 030104 developmental biology, Liver, Antigen retrieval, chemistry, Molecular Medicine, Chromatography, Liquid
Abstract: Formaldehyde fixation is widely used for long-term maintenance of tissue. However, due to formaldehyde-induced crosslinks, fixed tissue proteins are difficult to extract, which hampers mass spectrometry (MS) proteomic analyses. Recent years have seen the use of different combinations of high temperature and solubilizing agents (usually derived from antigen retrieval techniques) to unravel formaldehyde-fixed paraffin-embedded tissue proteomes. However, to achieve protein extraction yields similar to those of fresh-frozen tissue, high-temperature heating is necessary. Such harsh extraction conditions can affect sensitive amino acids and post-translational modifications, resulting in the loss of important information, while still not resulting in protein yields comparable to those of fresh-frozen tissue. Herein, the objective is to evaluate cleavable protein crosslinkers as fixatives that allow tissue preservation and efficient protein extraction from fixed tissue for MS proteomics under mild conditions. With this goal in mind, disuccinimidyl tartrate (DST) and dithiobis(succinimidylpropionate) (DSP) are investigated as cleavable fixating reagents. These compounds crosslink proteins by reacting with amino groups, leading to amide bond formation, and can be cleaved with sodium metaperiodate (cis-diols, DST) or reducing agents (disulfide bonds, DSP), respectively. Results show that cleavable protein crosslinking with DST and DSP allows tissue fixation with morphology preservation comparable to that of formaldehyde. In addition, cleavage of DSP improves protein recovery from fixed tissue by a factor of 18 and increases the number of identified proteins by approximately 20 % under mild extraction conditions compared with those of formaldehyde-fixed paraffin-embedded tissue. A major advantage of DSP is the introduction of well-defined protein modifications that can be taken into account during database searching. In contrast to DSP fixation, DST fixation followed by cleavage with sodium metaperiodate, although effective, results in side reactions that prevent effective protein extraction and interfere with protein identification. Protein crosslinkers that can be cleaved under mild conditions and result in defined modifications, such as DSP, are thus viable alternatives to formaldehyde as tissue fixatives to facilitate protein analysis from paraffin-embedded, fixed tissue.
Published: 2018

50. Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis

Author: Umiċeviċ Mirkov, Maša, Cui, Jing, Vermeulen, Sita H, Stahl, Eli A, Toonen, Erik J M, Makkinje, Remco R, Lee, Annette T, Huizinga, Tom W J, Allaart, Renee, Barton, Anne, Mariette, Xavier, Miceli, Corinne Richard, Criswell, Lindsey A, Tak, Paul P, de Vries, Niek, Saevarsdottir, Saedis, Padyukov, Leonid, Bridges, S Louis, van Schaardenburg, Dirk-Jan, Jansen, Tim L, Dutmer, Ellen A J, van de Laar, Mart A F J, Barrera, Pilar, Radstake, Timothy R D J, van Riel, Piet L C M, Scheffer, Hans, Franke, Barbara, Brunner, Han G, Plenge, Robert M, Gregersen, Peter K, Guchelaar, Henk-Jan, and Coenen, Marieke J H
Published: 2013
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