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Your search keyword '"Male, R. D."' showing total 2 results
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2 results on '"Male, R. D."'

1. Novel Synthesis of Impurity A, B, and C of Antidepressant Drug Trazodone.

Author

RANE, R. A., SURYAWANSHI, M. R., BABHULKAR, G. V., KHOBRAGADE, P. D., PATIL, R. K., MALE, R. D., CHINDHE, S. A., and PAWAR, D. K.

Subjects
TRAZODONE, SEROTONIN antagonists, ANTIDEPRESSANTS, SEROTONIN receptors, VENLAFAXINE
Abstract

Trazodone is a triazolopyridine analogue from the antidepressant class of serotonin receptor antagonists and reuptake inhibitors (SARIs). In the API and finished product of Trazodone impurity A, B and C are observed regularly. The present work discloses the first synthesis of these impurities with good to excellent yield and purity. [ABSTRACT FROM AUTHOR]

Published
2023
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2. Novel high yielding route for the synthesis of Melphalan dimer impurity G.

Author

Rane, R. A., Male, R. D., Babhulkar, G. V., Suryawanshi, M. R., Kumar, Dileep, Chindhe, S., Pawar, D., Moharir, S. R., and Patil, R. K.

Subjects
*MELPHALAN, *ANTINEOPLASTIC agents, *DIMERS, *HIGH performance liquid chromatography, *MASS spectrometry
Abstract

Melphalan dimer is an impurity from the synthesis of Melphalan (M216900) which is an antineoplastic agent. In this article, a new route for the synthesis of Melphalan dimer impurity G has been discussed. The new research provides the first high-yield, high-purity synthesis of this impurity. The impurity has been confirmed for purity using HPLC, and its structure has been identified using MS, ¹H and 13C NMR. [ABSTRACT FROM AUTHOR]

Published
2023
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