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4. Function/structure correlation in novel pH-dependent cationic liposomes for glioma cells transfection in vitro

Author

Esposito C. 1, Masotti A. 2, Del Grosso N. 3, Malizia D. 4, Bianco A. 5, Bonadies F. 6, Napolitano R. 7, Ortaggi G. 8, and Mossa G. 9

Subjects
trasfezione, liposomi, glioma, lipidi, terapia
Abstract

Cationic liposomes are good candidates as gene carriers in cell biology due to their ability to bind DNA through electrostatic interactions. These molecules are used as non-viral delivery systems in the gene therapy of glioma. pH-dependency and transfection efficiency of seven novel lipids (MORF-1, MORF-2, MORF-3, PIPR-1, PIPR-2, MM54 and DC-Amy) were studied. Two of these molecules (PIPR-2 and MM54) show a better transfection efficiency than that of some commercially available liposomes.

Published
2003

13. Poster Abstracts

Author

Littger, Ralf, primary, Alke, Alexandra, additional, Tewes, Bernhard, additional, Gropp, Felix, additional, Asai, T., additional, Watanabe, K., additional, Kuromi, K., additional, Kurohane, K., additional, Ogino, K., additional, Taki, T., additional, Tsukada, H., additional, Nakayama, J., additional, Oku, N., additional, Babai, I., additional, Matyas, G., additional, Baranji, L., additional, Milosevits, J., additional, Alving, C. R., additional, Bendas, G., additional, Rothe, U., additional, Scherphof, G. L., additional, Kamps, J. A. A. M., additional, Kessner, S., additional, Carafa, M., additional, Di Stefano, A., additional, Sozio, P., additional, Cacciatore, I., additional, Mosciatti, B., additional, Santucci, E., additional, Choice, E., additional, Harvie, P., additional, Galbraith, T., additional, Zunder, E., additional, Dutzar, B., additional, Anklesaria, P., additional, Paul, R., additional, Cocquyt, J., additional, De Cuyper, M., additional, Van der Meeren, P., additional, Cruz, M. E. M., additional, Gaspar, M. M., additional, Silva, M. T., additional, Dathe, M., additional, Nikolenko, H., additional, Wessolowski, A., additional, Schmieder, P., additional, Beyermann, M., additional, Bienert, M., additional, Santos, N. Dos, additional, Cox, K. A., additional, Allen, C., additional, Gallagher, R. C., additional, Ickenstein, L., additional, Mayer, L. D., additional, Bally, M. B., additional, Fischer, S., additional, Margalit, R., additional, Freisleben, H.-J., additional, Garidel, P., additional, Chen, H. C., additional, Moore, D., additional, Mendelsohn, R., additional, Keller, M., additional, Hildebrand, A., additional, Blume, A., additional, Girão da Cruz, M. T., additional, Simões, S., additional, Pedroso de Lima, M. C., additional, Graser, A., additional, Nahde, T., additional, Fahr, A., additional, Müller, R., additional, Müller-Brüsselbach, S., additional, Cudmore, S., additional, O'Mahony, D., additional, Hoving, S., additional, van Tiel, S. T., additional, Seynhaeve, A. L. B., additional, Ambagtsheer, G., additional, Eggermont, A. M. M., additional, ten Hagen, T. L. M., additional, Høyrup, P., additional, Jensen, S. S., additional, Jørgensen, K., additional, Iden, D., additional, Kuang, H., additional, Mullen, P., additional, Jacobs, C., additional, Roben, P., additional, Stevens, T., additional, Lollo, C., additional, Ishida, T., additional, Maeda, R., additional, Masuda, K., additional, Ichihara, M., additional, Kiwada, H., additional, Jung, K., additional, Reszka, R., additional, Kaiser, N., additional, Ohloff, I., additional, Linser-Haar, S., additional, Massing, U., additional, Schubert, R., additional, Kan, P., additional, Tsao, C. W., additional, Chen, W. K., additional, Wang, A. J., additional, Kimpfler, A., additional, Gerber, C., additional, Wieschollek, A., additional, Bruchelt, G., additional, Kobayashi, T., additional, Okada, Y., additional, Sone, S., additional, Harashima, H., additional, Maruyama, K., additional, Kondo, Masayo, additional, Lee, Chun Man, additional, Tanaka, Toshiyuki, additional, Su, Wei, additional, Kitagawa, Toru, additional, Ito, Toshinori, additional, Matsuda, Hikaru, additional, Murai, Toshiyuki, additional, Miyasaka, Masayuki, additional, Junji, Kimura, additional, Kondo, Masami, additional, Asai, Tomohiro, additional, Ogino, Koichi, additional, Taki, Takao, additional, Tsukada, Hideo, additional, Baba, Kazuhiko, additional, Oku, Naoto, additional, Koning, G. A., additional, Wauben, M. H. M., additional, Vestweber, D., additional, Everts, M., additional, Kok, R. J., additional, Schraa, A. J., additional, Molema, G., additional, Schiffelers, R. M., additional, Storm, G., additional, Kristl, J., additional, Šentjurc, M., additional, Abramović, Z., additional, Landry, S., additional, Perron, S., additional, Bestman-Smith, J., additional, Désormeaux, A., additional, Tremblay, M. J., additional, Bergeron, M. G., additional, Madeira, C., additional, Loura, L. M. S., additional, Fedorov, A., additional, Prieto, M., additional, Aires-Barros, M. R., additional, Marques, C. M., additional, Simões, S. I., additional, Cruz, M. E., additional, Cevc, G., additional, Martins, M. B., additional, Moreira, J. N., additional, Gaspar, R., additional, Allen, T. M., additional, Esposito, C., additional, Ortaggi, G., additional, Bianco, A., additional, Bonadies, F., additional, Malizia, D., additional, Napolitano, R., additional, Cametti, C., additional, Mossa, G., additional, Endert, Gerold, additional, Essler, Frank, additional, Lutz, Silke, additional, Panzner, Steffen, additional, Pastorino, F., additional, Brignole, C., additional, Pagnan, G., additional, Moase, E. H., additional, Ponzoni, M., additional, Pavelic, Z., additional, Škalko-Basnet, N., additional, Jalšenjak, I., additional, Penacho, N., additional, Pisano, C., additional, Bucci, F., additional, Serafini, S., additional, Martinelli, R., additional, Cupelli, A., additional, Marconi, A., additional, Ferrara, F. F., additional, Santaniello, M., additional, Critelli, L., additional, Tinti, O., additional, Luisi, P., additional, Carminati, P., additional, Galletti, B., additional, Sauer, I., additional, Schleef, M., additional, Voß, C., additional, Schmidt, T., additional, Flaschel, E., additional, König, S., additional, Wenger, T., additional, Dumond, J., additional, Bogetto, N., additional, Reboud-Ravaux, M., additional, Schramm, H. J., additional, Schramm, W., additional, Sheynis, T., additional, Rozner, S., additional, Kolusheva, S., additional, Satchell, D., additional, Jelnik, R., additional, Shigeta, Y., additional, Imanaka, H., additional, Ando, H., additional, Makino, T., additional, Baba, N., additional, Shimizu, K., additional, Takada, M., additional, Baba, K., additional, Namba, Y., additional, Simberg, Dmitri, additional, Danino, Dganit, additional, Talmon, Yeshayahu, additional, Minsky, Abraham, additional, Ferrari, Marilyn E., additional, Wheeler, Carl J., additional, Barenholz, Yechezkel, additional, Takada, Miki, additional, Shimizu, Kosuke, additional, Kuromi, Koici, additional, Takeuchi, Y., additional, North, J. R., additional, Nango, M., additional, Tewes, B., additional, Köchling, T., additional, Deissler, M., additional, Kühl, C., additional, Marx, U., additional, Strote, G., additional, Gropp, F., additional, Qualls, Marquita M., additional, Kim, Jong-Mok, additional, Thompson, David H., additional, Zhang, Zhi-Yi, additional, Shum, Pochi, additional, Collier, Joel H., additional, Hu, Bi-Huang, additional, Ruberti, Jeffrey W., additional, Messersmith, Phillip B., additional, Tsuruda, T., additional, Nakade, A., additional, Sadzuka, Y., additional, Hirota, S., additional, Sonobe, T., additional, Vorauer-Uhl, K., additional, Wagner, A., additional, Katinger, H., additional, Weeke-Klimp, A. H., additional, Bartsch, M., additional, Meijer, D. K. F., additional, Zeisig, R., additional, Walther, W., additional, Reß, A., additional, Fichtner, I., additional, Zschörnig, O., additional, Schiller, J., additional, Süß, M., additional, Bergmeier, C., additional, Arnold, K., additional, Nchinda, Godwin, additional, Überla, Klaus, additional, and Zschörnig, Olaf, additional

Published
2003
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14. Late Cenozoic tectonism and landscape development in the foreland of the Andes: Northern Sierras Pampeanas (26°-28°S), Argentina.

Author

Strecker, M. R., Cerveny, P., Bloom, A. L., and Malizia, D.

Abstract

The Argentine Sierras Pampeanas are reverse fault-bounded mountain blocks of Precambrian to Paleozoic basement rocks in the foreland of the central Andes. Uplift in the northernmost Sierras Pampeanas fault blocks of Sierra de Quilmes, Sierra Cumbres Calchaquíes, and Sierra Aconquija started about 7 Ma and became pronounced between 4 and 3.4 Ma. The movements culminated after 2.9 Ma, when the conformable Mio/Pliocene Santa María Group was overthrusted, faulted, and folded in the course of principal basement uplift. These movements created climate and base level conditions that resulted in the formation of five pediment levels in the deformed basin strata between 2.5 and 0.3 Ma. Tectonically induced base level changes in the piedmont resulted in three tectonism-related pediment surfaces between 2.5 and 0.6 Ma, which attest to the neotectonic activity in the Andean foreland. The chronology of young tectonic uplift contradicts models in which early uplift between 20 and 13 Ma is due to the interaction between high topography on the subducting Nazca Plate and the South American craton. In conjunction with the principal uplift of the adjacent Puna Plateau the northernmost Sierras Pampeanas are better explained by E-W compressional stresses superposed on a thinned lithosphere and inherited zones of structural weakness that facilitated uplift. [ABSTRACT FROM AUTHOR]

Published
1989
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15. Poster Abstracts

Author

Littger, Ralf, Alke, Alexandra, Tewes, Bernhard, Gropp, Felix, Asai, T., Watanabe, K., Kuromi, K., Kurohane, K., Ogino, K., Taki, T., Tsukada, H., Nakayama, J., Oku, N., Babai, I., Matyas, G., Baranji, L., Milosevits, J., Alving, C. R., Bendas, G., Rothe, U., Scherphof, G. L., Kamps, J. A. A. M., Kessner, S., Rothe, U., Bendas, G., Carafa, M., Di Stefano, A., Sozio, P., Cacciatore, I., Mosciatti, B., Santucci, E., Choice, E., Harvie, P., Galbraith, T., Zunder, E., Dutzar, B., Anklesaria, P., Paul, R., Cocquyt, J., De Cuyper, M., Van der Meeren, P., Cruz, M. E. M., Gaspar, M. M., Silva, M. T., Dathe, M., Nikolenko, H., Wessolowski, A., Schmieder, P., Beyermann, M., Bienert, M., Santos, N. Dos, Cox, K. A., Allen, C., Gallagher, R. C., Ickenstein, L., Mayer, L. D., Bally, M. B., Fischer, S., Margalit, R., Freisleben, H.-J., Garidel, P., Chen, H. C., Moore, D., Mendelsohn, R., Garidel, P., Keller, M., Hildebrand, A., Blume, A., Girão da Cruz, M. T., Simões, S., Pedroso de Lima, M. C., Graser, A., Nahde, T., Fahr, A., Müller, R., Müller-Brüsselbach, S., Harvie, P., Dutzar, B., Choice, E., Cudmore, S., O'Mahony, D., Anklesaria, P., Paul, R., Hoving, S., van Tiel, S. T., Seynhaeve, A. L. B., Ambagtsheer, G., Eggermont, A. M. M., ten Hagen, T. L. M., Høyrup, P., Jensen, S. S., Jørgensen, K., Iden, D., Kuang, H., Mullen, P., Jacobs, C., Roben, P., Stevens, T., Lollo, C., Ishida, T., Maeda, R., Masuda, K., Ichihara, M., Kiwada, H., Jung, K., Reszka, R., Kaiser, N., Ohloff, I., Linser-Haar, S., Massing, U., Schubert, R., Kan, P., Tsao, C. W., Chen, W. K., Wang, A. J., Kimpfler, A., Gerber, C., Wieschollek, A., Bruchelt, G., Schubert, R., Kobayashi, T., Okada, Y., Ishida, T., Sone, S., Harashima, H., Maruyama, K., Kiwada, H., Kondo, Masayo, Lee, Chun Man, Tanaka, Toshiyuki, Su, Wei, Kitagawa, Toru, Ito, Toshinori, Matsuda, Hikaru, Murai, Toshiyuki, Miyasaka, Masayuki, Junji, Kimura, Kondo, Masami, Asai, Tomohiro, Ogino, Koichi, Taki, Takao, Tsukada, Hideo, Baba, Kazuhiko, Oku, Naoto, Koning, G. A., Wauben, M. H. M., ten Hagen, T. L. M., Vestweber, D., Everts, M., Kok, R. J., Schraa, A. J., Molema, G., Schiffelers, R. M., Storm, G., Kristl, J., Šentjurc, M., Abramovi, Z., Landry, S., Perron, S., Bestman-Smith, J., Désormeaux, A., Tremblay, M. J., Bergeron, M. G., Madeira, C., Loura, L. M. S., Fedorov, A., Prieto, M., Aires-Barros, M. R., Marques, C. M., Simões, S. I., Cruz, M. E., Cevc, G., Martins, M. B., Moreira, J. N., Gaspar, R., Allen, T. M., Esposito, C., Ortaggi, G., Bianco, A., Bonadies, F., Malizia, D., Napolitano, R., Cametti, C., Mossa, G., Endert, Gerold, Essler, Frank, Lutz, Silke, Panzner, Steffen, Pastorino, F., Brignole, C., Pagnan, G., Moase, E. H., Allen, T. M., Ponzoni, M., Pavelic, Z., Škalko-Basnet, N., Jalšenjak, I., Penacho, N., Simões, S., Pedroso de Lima, M. C., Pisano, C., Bucci, F., Serafini, S., Martinelli, R., Cupelli, A., Marconi, A., Ferrara, F. F., Santaniello, M., Critelli, L., Tinti, O., Luisi, P., Carminati, P., Santaniello, M., Bucci, F., Tinti, O., Pisano, C., Critelli, L., Galletti, B., Luisi, P., Carminati, P., Sauer, I., Nikolenko, H., Dathe, M., Schleef, M., Voß, C., Schmidt, T., Flaschel, E., König, S., Wenger, T., Dumond, J., Bogetto, N., Reboud-Ravaux, M., Schramm, H. J., Schramm, W., Sheynis, T., Rozner, S., Kolusheva, S., Satchell, D., Jelnik, R., Shigeta, Y., Imanaka, H., Ando, H., Makino, T., Kurohane, K., Oku, N., Baba, N., Shimizu, K., Asai, T., Takada, M., Baba, K., Namba, Y., Oku, N., Simberg, Dmitri, Danino, Dganit, Talmon, Yeshayahu, Minsky, Abraham, Ferrari, Marilyn E., Wheeler, Carl J., Barenholz, Yechezkel, Takada, Miki, Shimizu, Kosuke, Kuromi, Koici, Asai, Tomohiro, Baba, Kazuhiko, Oku, Naoto, Takeuchi, Y., Kurohane, K., North, J. R., Namba, Y., Nango, M., Oku, N., Tewes, B., Köchling, T., Deissler, M., Kühl, C., Marx, U., Strote, G., Gropp, F., Qualls, Marquita M., Kim, Jong-Mok, Thompson, David H., Zhang, Zhi-Yi, Shum, Pochi, Collier, Joel H., Hu, Bi-Huang, Ruberti, Jeffrey W., Messersmith, Phillip B., Thompson, David H., Tsuruda, T., Nakade, A., Sadzuka, Y., Hirota, S., Sonobe, T., Vorauer-Uhl, K., Wagner, A., Katinger, H., Wagner, A., Vorauer-Uhl, K., Katinger, H., Weeke-Klimp, A. H., Bartsch, M., Meijer, D. K. F., Scherphof, G. L., Kamps, J. A. A. M., Zeisig, R., Walther, W., Reß, A., Fichtner, I., Zschörnig, O., Schiller, J., Süß, M., Bergmeier, C., Arnold, K., Nchinda, Godwin, Überla, Klaus, and Zschörnig, Olaf

Abstract

DOCSPER—A Synthetic Lipid Fit for In Vivo ApplicationDOCSPER [1,3-Dioleoyloxy-2-(N5-carbamoyl-spermine)-propane] is a cationic amphiphile consisting of a hydrophobic 1,3 dioleylglycerol moiety and threefold positively charged spermine head group (1). We optimised the 5-step-synthesis of the lipospermine and after up-scaling we have obtained sufficient amounts to initiate preclinical investigations. DOCSPER was tested for its ability to transfect eukaryotic cells in vitro. It has proven to possess high transfection efficiency in comparison to commercially available liposomal transfection agents. Furthermore, DOCSPER was extensively tested in several in vivo studies (23). These studies revealed a high transfection efficiency, whereas very low toxicity levels were detected. Thus, the results clearly indicate that the cationic lipid DOCSPER is a reliable, low-risk system for broad applications in gene therapy.Groth D. et al. Int J Pharm 1998; 162:143–157.Nikol S. et al. Int J Angiol 2000; 9:87–95.Armeanu S. et al. Mol Ther 2000; 1(4):366–375.

Published
1982
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18. La libera prestazione dei servizi e la libertà di stabilimento

Author

Casale D., E. Balletti, F. Carinci, D. Casale, G. Casale, C. Cattabriga, B. De Mozzi, V. Filì, N. Girelli, M. Lamberti, F. Lunardon, M. Malizia, D. Mezzacapo, A. Montanari, R. Nunin, A. Pizzoferrato, E. Traversa, F. Carinci, A. Pizzoferrato, Casale D., and E. Balletti, F. Carinci, D. Casale, G. Casale, C. Cattabriga, B. De Mozzi, V. Filì, M. Lamberti, F. Lunardon, M. Malizia, E. Menegatti, D. Mezzacapo, A. Montanari, R. Nunin, A. Pizzoferrato, E. Traversa, A. Zilli

Subjects
Mercato unico europeo – Mercato interno europeo – Libertà di stabilimento nell’UE – Libera prestazione di servizi nell’UE – Divieto di discriminazione sulla base della cittadinanza e della residenza di imprenditori e lavoratori autonomi – Armonizzazione e coordinamento del diritto del lavoro degli Stati membri – Libertà economiche del datore e diritti sociali dei lavoratori
Abstract

Il contributo analizza la disciplina, contenuta nel Trattato sul funzionamento dell'Unione Europea e nelle principali fonti di diritto derivato, in tema di libera prestazione di servizi e libertà di stabilimento delle imprese e dei lavoratori autonomi, alla luce delle fondamentali evoluzioni che nei decenni sono state introdotte dalla giurisprudenza della Corte di Lussemburgo su numerosi versanti regolativi: innovazioni spesso, ma non sempre, apprezzabili favorevolmente in termini di politica del diritto, secondo l'opinione dell'autore.

Published
2018

19. Libera circolazione dei lavoratori

Author

Anna Montanari, Nadia Girelli, E. Balletti, F. Carinci, D. Casale, G. Casale, C. Cattabriga, B. De Mozzi, V. Filì, N. Girelli, M. Lamberti, F. Lunardon, M. Malizia, D. Mezzacapo, A. Montanari, R. Nunin, A. Pizzoferrato, E. Traversa, Franco Carinci, Alberto Pizzoferrato, Anna Montanari, and Nadia Girelli

Subjects
Diritto dell'Unione europea, Libertà di circolazione dei lavoratori, direttiva 2004/38/Ce
Abstract

Il saggio illustra le principali novità in tema di libertà di circolazione dei lavoratori all'interno dell'Unione europea. Il contributo è opera della riflessione comune delle autrici; in ogni caso i §§ 1 e 2 sono da attribuire a Nadia Girelli e i §§ 3 e 4 sono da attribuire ad Anna Montanari

Published
2018

20. Il riconoscimento di titoli e qualifiche professionali nell’UE

Author

Casale D., E. Balletti, F. Carinci, D. Casale, G. Casale, C. Cattabriga, B. De Mozzi, V. Filì, N. Girelli, M. Lamberti, F. Lunardon, M. Malizia, D. Mezzacapo, A. Montanari, R. Nunin, A. Pizzoferrato, E. Traversa, Carinci F., Pizzoferrato A., Casale D., and E. Balletti, F. Carinci, D. Casale, G. Casale, C. Cattabriga, B. De Mozzi, V. Filì, M. Lamberti, F. Lunardon, M. Malizia, E. Menegatti, D. Mezzacapo, A. Montanari, R. Nunin, A. Pizzoferrato, E. Traversa, A. Zilli

Subjects
titoli professionali, Unione Europea, riconoscimento automatico, mutuo riconoscimento, professioni, lavoro autonomo, lavoro subordinato, armonizzazione, coordinamento, cooperazione amministrativa
Abstract

Il contributo analizza la disciplina dell'UE in tema di riconoscimento delle qualifiche e dei titoli professionali di lavoratori subordinati, autonomi, professionisti, imprenditori (comprese le questioni inerenti a titoli e cittadini extra-UE). In particolare, vengono considerate le regole semplificate al fine della prestazione di servizi transfrontaliera e soprattutto il triplice regime di riconoscimento (automatico per armonizzazione della disciplina materiale speciale, per esperienza professionale, regime generale residuale) finalizzato alla libertà di stabilimento, oltreché la casistica specifica (riconoscimento parziale, accesso al pubblico impiego, valenza dei tirocini professionali, disciplina speciale per le professioni legali, etc.). Il delineato quadro denota un’evoluzione normativa notevole negli ultimi due decenni, assai apprezzabile ma ancora non pienamente soddisfacente.

Published
2018

21. Parità di trattamento e divieto di discriminazione

Author

Anna Montanari, Nadia Girelli, E. Balletti, F. Carinci, D. Casale, G. Casale, C. Cattabriga, V. Filì, N. Girelli, M. Lamberti, F. Lunardon, A. Montanari, A. Pizzoferrato, R. Nunin, E. Traversa, Carinci Franco, Pizzoferrato Alberto, Montanari, Anna, Girelli Nadia, E. Balletti, F. Carinci, D. Casale, G. Casale, C. Cattabriga, B. De Mozzi, V. Filì, N. Girelli, M. Lamberti, F. Lunardon, M. Malizia, D. Mezzacapo, A. Montanari, R. Nunin, A. Pizzoferrato, E. Traversa, Franco Carinci, Alberto Pizzoferrato, Anna Montanari, and Nadia Girelli

Subjects
diritto europeo del lavoro, parità di trattamento, divieto di discriminazione, tutela della dignità del lavoratore, Diritto dell'Unione europea, parità di trattamento, divieti di discriminazione, parità retributiva, parità uomo-donna, azioni positive, congedi parentali
Abstract

Nel contributo viene tracciato un quadro dell'evoluzione del principio di parità di trattamento e del divieto di discriminazione nel rapporto di lavoro nell'ambito del diritto europeo, con particolare riferimento alla direttiva 2006/54/CE, alla disciplina dei congedi parentali e alle azioni di difesa contro le discriminazioni. Nel contributo si dà conto altresì delle più recenti sentenze in materia della Corte di giustizia europa.

Published
2015

23. Pari opportunità

Author

CHISTOLINI, Sandra, G. MALIZIA, D. ANTONIETTI, M. TONINI A CURA DI, and Chistolini, Sandra

Published
2004

24. Abbandono

Author

CHISTOLINI, Sandra, G. MALIZIA, D. ANTONIETTI, M. TONINI A CURA DI, and Chistolini, Sandra

Published
2004

25. Abbandono – Pari opportunità – Sperimentazione – Successo scolastico e professionale –

Author

CHISTOLINI, Sandra, G. Malizia, D. Antonietti, M. Tonini (a cura di), and Chistolini, Sandra

Subjects
pari opportunità, sperimentazione, Formazione professionale, successo scolastico e professionale, abbandono
Abstract

Le voci sono contenute nel volume su "Le parole chiave della formazione professionale" inteso ad offrire una visione organica dell'istruzione e della formazione professionale. Sono presentate tenendo conto della grammatica comune ed offrono materiale utile ed aggiornato ai formatori impegnati nella elaborazione di piani formativi personalizzati.

Published
2004

26. Sperimentazione

Author

CHISTOLINI, Sandra, G. MALIZIA, D. ANTONIETTI, M. TONINI A CURA DI, and Chistolini, Sandra

Published
2004

28. The Effect of Regional Anesthetic Sphenopalatine Ganglion Block on Self-Reported Pain in Patients With Status Migrainosus.

Author

Mehta D, Leary MC, Yacoub HA, El-Hunjul M, Kincaid H, Koss V, Wachter K, Malizia D, Glassman B, and Castaldo JE

Subjects
Adult, Aged, Anesthetics, Local therapeutic use, Anti-Inflammatory Agents therapeutic use, Dexamethasone therapeutic use, Female, Humans, Male, Middle Aged, Retrospective Studies, Ropivacaine therapeutic use, Self Report, Treatment Outcome, Migraine Disorders therapy, Pain Management methods, Sphenopalatine Ganglion Block methods
Abstract

Background: Status migrainosus (SM) is defined as a debilitating migraine attack lasting more than 72 hours in patients previously known to suffer from migraine headache. Typically, these attacks fail to respond to over the counter and abortive medications. The sphenopalatine ganglion (SPG) plays a critical role in propagating both pain and the autonomic symptoms commonly associated with migraines. SPG block via transnasal lidocaine is moderately effective in reducing migraine symptoms, but this approach is often poorly tolerated and the results are inconsistent. We proposed that an SPG block using a suprazygomatic injection approach would be a safe and effective option to abort or alleviate pain and autonomic symptoms of SM., Methods: Through a retrospective records review, we identified patients with a well-established diagnosis of migraine, based on the International Headache Society criteria. Patients selected for study inclusion were diagnosed with SM, had failed to respond to 2 or more abortive medications, and had received a suprazygomatic SPG block. Patients had also been asked to rate their pain on a 1-10 Likert scale, both before and 30 minutes after the injection., Results: Eighty-eight consecutive patients (20 men and 68 women) received a total of 252 suprazygomatic SPG block procedures in the outpatient headache clinic after traditional medications failed to abort their SM. At 30 minutes following the injections, there was a 67.2% (±26.6%) reduction in pain severity with a median reduction of 5 points (IQR= -6 to -3) on the Likert scale (ranging from 1 to 10). Overall, patients experienced a statistically significant reduction in pain severity (P < .0001)., Conclusion: The SPG is known to play an integral role in the pathophysiology of facial pain and the trigeminal autonomic cephalalgias, although its exact role in the generation and maintenance of migraine headache remains unclear. Regional anesthetic suprazygomatic SPG block is potentially effective for immediate relief of SM. We believe the procedure is simple to perform and has minimal risk., (© 2018 American Headache Society.)

Published
2019
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29. Common plants as alternative analytical tools to monitor heavy metals in soil.

Author

Malizia D, Giuliano A, Ortaggi G, and Masotti A

Abstract

Background: Herbaceous plants are common vegetal species generally exposed, for a limited period of time, to bioavailable environmental pollutants. Heavy metals contamination is the most common form of environmental pollution. Herbaceous plants have never been used as natural bioindicators of environmental pollution, in particular to monitor the amount of heavy metals in soil. In this study, we aimed at assessing the usefulness of using three herbaceous plants (Plantago major L., Taraxacum officinale L. and Urtica dioica L.) and one leguminous (Trifolium pratense L.) as alternative indicators to evaluate soil pollution by heavy metals., Results: We employed Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES) to assess the concentration of selected heavy metals (Cu, Zn, Mn, Pb, Cr and Pd) in soil and plants and we employed statistical analyses to describe the linear correlation between the accumulation of some heavy metals and selected vegetal species. We found that the leaves of Taraxacum officinale L. and Trifolium pratense L. can accumulate Cu in a linearly dependent manner with Urtica dioica L. representing the vegetal species accumulating the highest fraction of Pb., Conclusions: In this study we demonstrated that common plants can be used as an alternative analytical tool for monitoring selected heavy metals in soil.

Published
2012
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