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Objectives: There is conflicting evidence about the efficacy of statin use in regard to clinical outcomes in patients with coronavirus disease 2019 (COVID-19). A systematic review and meta-analysis was performed to examine the effect of statin use on mortality in COVID-19 patients. Methods: The electronic databases were searched, from inception to March 3, 2021. Unadjusted and adjusted effect estimates with their 95% confidence intervals (95% CI) were pooled using random-effects models. Results: Twenty-five cohort studies involving 147 824 patients were included. The mean age of the patients ranged from 44.9 to 70.9 years; 57% of patients were male and 43% were female. The use of statins was not associated with mortality when applying the unadjusted risk ratio (uRR 1.16, 95% CI 0.86–1.57; 19 studies). In contrast, meta-analyses of the adjusted odds ratio (aOR 0.67, 95% CI 0.52–0.86; 11 studies) and adjusted hazard ratio (aHR 0.73, 95% CI 0.58–0.91; 10 studies) showed that statins were independently associated with a significant reduction in mortality. Subgroup analyses showed that only chronic use of statins significantly reduced mortality according to the adjusted models. Conclusions: The use of statins was found to be associated with a lower risk of mortality in COVID-19 patients based on adjusted effects of cohort studies. However, randomized controlled trials are still needed to confirm these findings.

Objetivos: El objetivo de este trabajo es determinar la proporción de ansiedad en estudiantes españoles de medicina durante la pandemia de COVID-19. Metodología: 31 estudiantes del grado de medicina de una universidad española contestaron un cuestionario on-line en abril del 2020. La escala GAD-7 se utilizó para evaluar sintomatología ansiosa autorreportada, y se utilizaron los puntos de corte para clasificarlos en ansiedad probable. Resultados: El 64,5% de la muestra presentó ansiedad, siendo más prevalente entre mujeres y los más jóvenes. Conclusiones: La prevalencia de ansiedad en la muestra analizada sugiere la necesidad de evaluar sintomatología ansiosa entre los estudiantes de medicina durante la pandemia de COVID-19 y establecer programas de apoyo psicológico adecuados. Estudios epidemiológicos futuros con muestras amplias y representativas se hacen necesarios para hacer un seguimiento de la salud mental de este colectivo.

Introduction: The current pandemic due to a new coronavirus (SARS-Cov-2) has claimed the health and lives of many people worldwide. This has a negative impact on the mental health of health personnel, which includes medical students. Objective: To determine the degree of anxiety present in first-year medical students from a private university, Lima-Peru. Methods: The sample consisted of 57 students from private university in Lima Perú. The scale was applied to measure Generalized Anxiety Disorder-7 (GAD-7). The data were analyzed using frequency and contingency tables, in addition bivariate analysis was performed applying the statistical tests X2 and Student's t. Results: 75.4% of the medical students manifested some degree of anxiety. A statistically significant association was found between female sex and anxiety (p = 0.045). Likewise, there was no association between the variables age and anxiety (p = 0.058). Conclusion: First-year medical students showed high levels of anxiety during the current pandemic, with women being among those who anxiety occurs more frequently. The development of intervention strategies in university centers for the care of mental health of health sciences students is timely.