124 results on '"Marcuccio, L"'
Search Results
2. BDNF Val66Met polymorphism and brain volumes in multiple sclerosis
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Dinacci, D., Tessitore, A., Russo, A., De Bonis, M. L., Lavorgna, L., Picconi, O., Sacco, R., Bonavita, S., Gallo, A., Servillo, G., Marcuccio, L., Comerci, M., Galletti, P., Alfano, B., and Tedeschi, G.
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- 2011
- Full Text
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3. Executive resting-state network connectivity in migraine with and without aura: EP3257
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Marcuccio, L., Russo, A., Esposito, F., Giordano, A., De Stefano, M., Cirillo, M., Tedeschi, G., and Tessitore, A.
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- 2014
4. Abnormal thalamic function in patients with vestibular migraine: EP1234
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Conte, F., Russo, A., Marcelli, V., Esposito, F., Corvino, V., Marcuccio, L., Giannone, A., Conforti, R., Marciano, E., Tedeschi, G., and Tessitore, A.
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- 2014
5. EHMTI-0055. Abnormal thalamic function in patients with vestibular migraine
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Russo, A, Marcelli, V, Esposito, F, Corvino, V, Marcuccio, L, Giannone, A, Conforti, R, Marciano, E, Gioacchino, T, and Tessitore, A
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- 2014
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6. Legionella pneumophila and related organisms induce the generation of procoagulant activity by peripheral mononuclear cells in vitro
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Miragliotta, G., Semeraro, N., Marcuccio, L., and Fumarold, D.
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- 1982
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7. In vitro antimicrobial properties of azidothymidine (AZT)
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Rosa Monno, Marcuccio, L., Valenza, M. A., Leone, E., Bitetto, C., Larocca, A., Maggi, P., Quarto, M., Monno, R, Marcuccio, L, Valenza, Ma, Leone, E, Bitetto, C, Larocca, A, Maggi, P, and Quarto, M.
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Acquired Immunodeficiency Syndrome ,Bacteria ,Anti-HIV Agents ,HIV Seropositivity ,Humans ,Microbial Sensitivity Tests ,Zidovudine - Abstract
In addition to the activity against a number of retroviruses, azidothymidine (AZT) has antibacterial activity against many bacteria. The effect of AZT on 224 bacterial species, including 25 strains of Salmonella spp. isolated from HIV-positive patients, was tested. AZT had no activity against all the strains of tested Gram-positive bacteria and Pseudomonas species (MIC128 micrograms/ml), whereas a different activity against Enterobacteriaceae (MIC range, 128 to 0.06 micrograms/ml) was found. In particular 76% of Salmonella spp. isolated from HIV-positive patients showed MICs1 microgram/ml, whereas similar MICs value were found in 50% of the Salmonella strains isolated from HIV-negative subjects. In addition, strains of Salmonella isolated from stools were more resistant to AZT when compared to strains isolated from blood even if this difference was not statistically significant. No correlation was found between length of therapy and Salmonella resistance to AZT in HIV-positive patients and a low incidence of Salmonella relapses in subjects treated with AZT was observed. The possibility that AZT may have an ancillary benefit in controlling some bacterial infections in AIDS patients is discussed.
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- 1997
8. Leptospirosi in cavalli importati dall'Europa dell'Est: una nuova potenziale fonte di infezione umana in Puglia
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Maggi P, Pece S, Lo Caputo S, Federico M, Marcuccio L., Maggi, P, Pece, S, Lo Caputo, S, Federico, M, and Marcuccio, L.
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- 1994
9. Indicatori di progressione del’aterosclerosi in pazienti con stenosi carotidea: la risposta immuno-umorale all’antigene di 12 K-DA
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Sposato, Angela, Sciarra, G., Tesori, M. C., Mastroluca, E., Forcione, A., Fabbri, F., Marcuccio, L., Riganò, R., Profumo, E., and Capoano, Raffaele
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- 2004
10. INDICATORI DI PROGRESSIONE DELLA ATEROSCLEROSI IN PAZIENTI CON STENOSI CAROTIDEA: LA RISPOSTA IMMUNO-UMORALE ALL’ANTIGENE DI 12 kDA
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Sposato, A., Sciarra, G., Tesori, M. C., Mastroluca, E., Forcione, A., Fabbri, F., Marcuccio, L., Rigano', R., Profumo, E., and Capoano, Raffaele
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- 2004
11. L’ernia lombare: un caso clinico
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Zappa, B., Sposato, Angela, Costanzo, A., Sciarra, G., Tesori, . M. C., Mastroluca, E., Guerrieri, E., Marcuccio, L., Forcione, . A., and Capoano, Raffaele
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- 2004
12. Occupational risk linked to leptospirae in Apulia
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Squarcione, S., Paolo Maggi, Pece, S., Lo Caputo, S., Marcuccio, L., Squarcione, S, Maggi, P, Pece, S, Lo Caputo, S, and Marcuccio, L.
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Adult ,Male ,Adolescent ,Occupational Diseases ,Italy ,Risk Factors ,Zoonoses ,Animals ,Humans ,Female ,Horse Diseases ,Leptospirosis ,Horses ,Child ,Aged - Published
- 1993
13. Abnormal thalamic function in patients with vestibular migraine
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Russo, A., primary, Marcelli, V., additional, Esposito, F., additional, Corvino, V., additional, Marcuccio, L., additional, Giannone, A., additional, Conforti, R., additional, Marciano, E., additional, Tedeschi, G., additional, and Tessitore, A., additional
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- 2014
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14. Screening per la leptospirosi su un campione di popolazione del Barese
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Maggi P, Marcuccio L, Marcuccio C, Maggi, P, Marcuccio, L, and Marcuccio, C
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- 1990
15. BDNF Val66Met polymorphism and brain volumes in multiple sclerosis
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Dinacci, D., primary, Tessitore, A., additional, Russo, A., additional, De Bonis, M. L., additional, Lavorgna, L., additional, Picconi, O., additional, Sacco, R., additional, Bonavita, S., additional, Gallo, A., additional, Servillo, G., additional, Marcuccio, L., additional, Comerci, M., additional, Galletti, P., additional, Alfano, B., additional, and Tedeschi, G., additional
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- 2010
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16. Identification of IP-10 and IL-5 as Proteins Differentially Expressed in Human Complicated and Uncomplicated Carotid Atherosclerotic Plaques
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Profumo, E., primary, Buttari, B., additional, Tosti, M.E., additional, Alessandri, C., additional, Valesini, G., additional, Marcuccio, L., additional, Tesori, C., additional, Capoano, R., additional, Salvati, B., additional, and Riganò, R., additional
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- 2010
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17. Letter to the editors
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Fumarola, D., Marcuccio, L., Brandonisio, O., Monno, R., Longo-Papadia, L., Kemmerich, B., and Lode, H.
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- 1981
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18. Evaluation of Nonspecific Immunity and Plasma Levels of Interferon-γ, Interleukin-6 and Tumor Necrosis Factor-α in Preeclampsia
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Munno, I., primary, Chiechi, L. M., additional, Lacedra, G., additional, Berardesca, C., additional, Patimo, C., additional, Marcuccio, L., additional, Nardelli, P., additional, and Loizzi, P., additional
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- 1999
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19. Effect of Leucogenenol on Human Peripheral Lymphocyte Cultures.
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Fumarola, D., Marcuccio, L., and De Rinaldis, P.
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- 1972
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20. [Effects of leucogenenol on rabbit skin homografts]
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Giordano, D, Scuderi, Nicolo', and Marcuccio, L.
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Graft Rejection ,Animals ,Transplantation, Homologous ,Spiro Compounds ,Leucogenenol ,Rabbits ,Skin Transplantation - Published
- 1973
21. The effect of azidothymidine on germ tube formation in Candida albicans
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Rosa Monno, Caggiano, G., Coscia, M. F., and Marcuccio, L.
22. Spontaneous binding of Vibrio cholerae to human leucocytes
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Monno, R., Valenza, M. A., Panaro, M. A., Lisi, S., Marcuccio, L., Danila De Vito, and Mitolo, V.
23. Abnormal thalamic function in patients with vestibular migraine
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Conte, F., Russo, A., Marcelli, V., Esposito, F., Corvino, V., Marcuccio, L., Giannone, A., renata conforti, Marciano, E., Tedeschi, G., and Tessitore, A.
24. Polarizing response of human polymorphonuclear cells to Vibrio cholerae
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Valenza, M. A., Monno, R., Vito, D., Mitolo, V., Sabrina LISI, Marcuccio, C., Marcuccio, L., and Panaro, M. A.
25. Cognitive Impairment in Convalescent COVID-19 Patients Undergoing Multidisciplinary Rehabilitation: The Association with the Clinical and Functional Status
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Pasquale Moretta, Pasquale Ambrosino, Anna Lanzillo, Laura Marcuccio, Salvatore Fuschillo, Antimo Papa, Gabriella Santangelo, Luigi Trojano, Mauro Maniscalco, Moretta, Pasquale, Ambrosino, Pasquale, Lanzillo, Anna, Marcuccio, Laura, Fuschillo, Salvatore, Papa, Antimo, Santangelo, Gabriella, Trojano, Luigi, Maniscalco, Mauro, Moretta, P., Ambrosino, P., Lanzillo, A., Marcuccio, L., Fuschillo, S., Papa, A., Santangelo, G., Trojano, L., and Maniscalco, M.
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Health Information Management ,disability ,exercise ,Leadership and Management ,Health Policy ,occupational medicine ,outcome ,COVID-19 ,Health Informatics ,cognitive impairment ,rehabilitation - Abstract
Background. Cognitive impairment has been reported in the aftermath of severe acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) infection. We investigated the possible association between cognitive impairment and the main clinical and functional status variables in a cohort of convalescent COVID-19 patients without premorbid diseases potentially affecting cognition. Methods. We consecutively screened for inclusion of convalescent COVID-19 patients referring to a post-acute care facility for pulmonary rehabilitation. All the enrolled patients were assessed for cognitive functions. We also investigated features of psychological distress (anxiety, depression, symptoms of posttraumatic stress disorder and quality of life) and cardiac and pulmonary functional status. Results. The 63 enrolled patients (mean age 59.82 ± 10.78, male gender = 47) showed a high frequency of depressive symptoms (76.2%) and anxiety (55.5%), and a high prevalence of symptoms of posttraumatic stress disorder (PTSD, 44.4%). About half of the total sample showed reduced cognitive efficiency (RCE, 44.4%) in the domains of spatial and verbal long-term memory and executive functions. Patients with RCE more frequently showed alteration of blood pressure (BP) circadian rhythm (p = 0.01), higher levels of D-Dimer (p = 0.03), had experienced a severe illness (p = 0.02), had longer disease duration (p = 0.04), more clinically relevant symptoms of PTSD (p = 0.02), more frequent cognitive complaints (p = 0.002), higher anxiety scores (p = 0.01) and lower quality of life (p = 0.02) than patients with normal cognitive efficiency. Conclusions. Our findings indicated a possible association between the RCE after COVID-19 and some cardiological variables, including some indirect measures of a residual autonomic disorder, such as the presence of an altered BP circadian rhythm. Future research studies with large samples are needed to provide valid conclusions.
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- 2022
26. BDNF Val66Met polymorphism and brain volumes in multiple sclerosis
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Laura Marcuccio, Antonio Russo, Marco Comerci, M. L. De Bonis, Alessandro Tessitore, G. Tedeschi, D. Dinacci, Simona Bonavita, Bruno Alfano, G. Servillo, Luigi Lavorgna, O. Picconi, Rosaria Sacco, Antonio Gallo, Patrizia Galletti, Dinacci, D, Tessitore, Alessandro, Russo, Antonio, DE BONIS, Ml, Lavorgna, L, Picconi, O, Sacco, R, Bonavita, Simona, Gallo, Antonio, Servillo, G, Marcuccio, L, Comerci, M, Galletti, P, Alfano, B, and Tedeschi, Gioacchino
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Adult ,Male ,Brain atrophy ,medicine.medical_specialty ,Multiple Sclerosis ,Neurology ,Adolescent ,Genotype ,DNA Mutational Analysis ,Dermatology ,Polymorphism, Single Nucleotide ,White matter ,Disability Evaluation ,Young Adult ,Methionine ,Atrophy ,Gene Frequency ,Internal medicine ,Image Processing, Computer-Assisted ,medicine ,Humans ,Allele ,Pathological ,Brain-derived neurotrophic factor ,Analysis of Variance ,BDNF polymorphism ,Brain-Derived Neurotrophic Factor ,Multiple sclerosis ,Brain ,Valine ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Psychiatry and Mental health ,medicine.anatomical_structure ,Endocrinology ,Case-Control Studies ,Regression Analysis ,Female ,Neurology (clinical) ,Psychology ,Neuroscience ,MRI - Abstract
Brain derived neurotrophic factor (BDNF) regulates several CNS physiological and pathological processes. To investigate in multiple sclerosis (MS) patients, the relationship between the Val66Met polymorphism of BDNF and clinical markers of disease activity and MRI markers of focal and diffuse brain pathologies. 45 MS patients and 34 healthy controls (HCs) were genotyped and subjected to clinical-MRI examination. Global white matter fraction (gWM-f), gray matter-f (GM-f), cerebrospinal fluid-f (CSF-f), and abnormal WM-f were measured. We studied 26 Val/Val and 19 Val/Met patients and 23 Val/Val and 11 Val/Met HCs. We found that Val/Val patients had lower GM-f and higher CSF-f than Val/Val HCs; such differences were not statistically significant comparing Val/Met patients to HCs. The regression analysis showed that both Val/Met genotype and relapse number were associated with lower CSF-f. Our data suggest that Met allele might be a protective factor against MS as it is associated to a lower brain atrophy.
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- 2010
27. Abnormal thalamic function in patients with vestibular migraine
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Renata Conforti, Alessandro Tessitore, Fabrizio Esposito, Laura Marcuccio, Antonio Dello Russo, Elio Marciano, Vincenzo Marcelli, Virginia Corvino, Gioacchino Tedeschi, Antonio Giannone, Russo, Antonio, Marcelli, V, Esposito, F, Corvino, V, Marcuccio, L, Giannone, A, Conforti, Renata, Marciano, E, Tedeschi, Gioacchino, Tessitore, Alessandro, A., Russo, V., Marcelli, F., Esposito, V., Corvino, L., Marcuccio, A., Giannone, R., Conforti, Marciano, Elio, G., Tedeschi, A., Tessitore, Cognitive Neuroscience, and RS: FPN CN 1
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Male ,Migraine without Aura ,VM 5 vestibular migraine ,EVENT-RELATED FMRI ,Aura ,functional Magnetic Resonance Imaging ,Migraine ,physiopathology, Vestibular Function Tests ,methods, Caloric Tests, Cerebral Cortex ,CALORIC STIMULATION ,Stimulation ,GALVANIC STIMULATION ,Thalamus ,MwoA 5 migraine without aura ,Vertigo ,Neural Pathways ,Prospective Studies ,Prospective cohort study ,Vestibular system ,Cerebral Cortex ,biology ,VERTIGO ,PAIN ,Magnetic Resonance Imaging ,Pathophysiology ,EXPECTATION ,Anesthesia ,Vestibule ,Cardiology ,Female ,Vestibule, Labyrinth ,Psychology ,Adult ,medicine.medical_specialty ,BOLD 5 blood oxygen level–dependent ,Migraine Disorders ,DIAGNOSTIC-CRITERIA ,methods ,HC 5 healthy control ,Internal medicine ,medicine ,Caloric Tests ,otorhinolaryngologic diseases ,Humans ,MODULATION ,IMAGE-ANALYSIS ,ICHD 5 International Classification of Headache Disorder ,Vestibular Function Tests ,medicine.disease ,biology.organism_classification ,FIR 5 finite impulse response ,GLM 5 general linear model ,Neurology (clinical) ,sense organs ,physiopathology ,RESPONSES - Abstract
OBJECTIVE: To investigate the functional response of neural pathways associated with vestibular stimulation in patients with vestibular migraine (VM). METHODS: Twelve patients with VM underwent whole-brain blood oxygen level-dependent (BOLD) fMRI during ear irrigation with cold water. The functional response of neural pathways to this stimulation in patients with VM was compared with age- and sex-matched patients with migraine without aura and healthy controls. Secondary analyses explored associations between BOLD signal change and clinical features of migraine in patients. RESULTS: We observed a robust cortical and subcortical pattern of BOLD signal change in response to ear irrigation across all participants. Patients with VM showed a significantly increased thalamic activation in comparison with both patients with migraine without aura and healthy controls. The magnitude of thalamic activation was positively correlated with the frequency of migraine attacks in patients with VM. CONCLUSIONS: We provide novel evidence for abnormal thalamic functional response to vestibular stimulation in patients with VM. These functional abnormalities in central vestibular processing may contribute to VM pathophysiology.
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- 2014
28. Executive resting-state network connectivity in migraine without aura
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Gioacchino Tedeschi, Fabrizio Salemi, Manuela De Stefano, Antonio Russo, Laura Marcuccio, Daniele Corbo, Alessandro Tessitore, Fabrizio Esposito, Alfonso Giordano, Renata Conforti, Russo, Antonio, Tessitore, Alessandro, Giordano, A, Corbo, D, Marcuccio, L, De Stefano, M, Salemi, F, Conforti, Renata, Esposito, F, and Tedeschi, Gioacchino
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Adult ,Male ,Migraine without Aura ,Aura ,Intelligence ,Neuropsychological Tests ,Gyrus Cinguli ,Executive Function ,Young Adult ,Cognition ,Parietal Lobe ,medicine ,Humans ,Ictal ,Prospective Studies ,Migraine, executive functions, resting-state fMRI, fronto-parietal network ,Resting state fMRI ,business.industry ,Neuropsychology ,Pain Perception ,General Medicine ,Executive functions ,medicine.disease ,Magnetic Resonance Imaging ,Frontal Lobe ,Frontal lobe ,Migraine ,Case-Control Studies ,Female ,Neurology (clinical) ,Nerve Net ,business ,Neuroscience ,Executive dysfunction - Abstract
Background: Converging neuropsychological evidence suggests that in migraine executive functions (EF) may be affected during interictal periods. Objective: To evaluate the functional connectivity of the fronto-parietal networks (FPN) known to be associated with EF, in migraine without aura (MwoA) patients, in the interictal period, in comparison to healthy controls (HC). Methods: Using resting-state functional MRI (RS-fMRI), we compared functional connectivity within the FPN in 14 patients with MwoA versus 14 sex- and age-matched HC, and assessed the correlation between functional connectivity within FPN, clinical features of MwoA patients, and EF. We used voxel-based morphometry to assess whether between-group differences in functional connectivity were dependent on structural differences. Results: Neuropsychological data revealed no significant executive dysfunction in MwoA patients. RS-fMRI showed that MwoA patients, compared to HC, had significant functional connectivity reduction within the right FPN and specifically in the middle frontal gyrus (MFG) and the dorsal anterior cingulate cortex. In addition, we found that MFG reduced connectivity was negatively correlated with the pain intensity of migraine attacks. There were no structural differences between the two groups. Conclusions: Our data suggest that, even in the absence of clinically evident EF deficits, MwoA is associated with reduced FPN functional connectivity. This study provides further insights into the complex scenario of migraine mechanisms.
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- 2012
29. Pain processing in patients with migraine: an event-related fMRI study during trigeminal nociceptive stimulation
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Gioacchino Tedeschi, Laura Marcuccio, Florindo d’Onofrio, Antonella Paccone, Andrea Truini, Antonio Russo, Alessandro Tessitore, Renata Conforti, Alfonso Giordano, Fabrizio Esposito, Russo, Antonio, Tessitore, Alessandro, Esposito, F, Marcuccio, L, Giordano, A, Conforti, Renata, Truini, A, Paccone, A, D’Onofrio, F, and Tedeschi, Gioacchino
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Adult ,Male ,Pain Threshold ,Migraine Disorders ,fmri ,anterior cingulate cortex ,pain processing ,secondary somatosensory cortex ,migraine ,pons ,Pain processing ,Physical Stimulation ,Image Processing, Computer-Assisted ,medicine ,Noxious stimulus ,Humans ,Trigeminal Nerve ,Evoked potential ,Anterior cingulate cortex ,Migraine ,Pain Measurement ,Analysis of Variance ,Brain Mapping ,medicine.diagnostic_test ,Secondary somatosensory cortex ,Somatosensory Cortex ,medicine.disease ,Magnetic Resonance Imaging ,Pons ,Oxygen ,medicine.anatomical_structure ,Nociception ,Neurology ,Hyperalgesia ,Case-Control Studies ,Anesthesia ,Female ,Neurology (clinical) ,Functional magnetic resonance imaging ,Psychology - Abstract
We explored the functional pattern of the pain-processing network in patients with migraine, in the interictal periods, during trigeminal noxious stimulation. Contact heat evoked potential stimulation induced thermal pain and functional magnetic resonance imaging were used to measure whole-brain activation in 16 patients with episodic migraine without aura and 16 age- and gender-matched healthy controls in response to a severe (53°C) noxious, a moderate (51°C) noxious, and a control (41°C) stimulus applied to the maxillary skin. When comparing the fMRI activation over the entire brain, patients with migraine, with respect to healthy controls, showed a significantly greater activation in the perigenual part of anterior cingulate cortex at 51°C and less activation in the bilateral secondary somatosensory cortex at 53°C. A group-by-stimulus interaction analysis revealed a region in the pons showing a divergent response in patients and healthy controls. Correlation analyses demonstrated that the pons activation correlated with higher headache-related disability in patients. Our findings demonstrate increased antinociceptive activity in patients with migraine, which may represent a compensatory reorganization to modulate pain perception at the same intensity of healthy controls.
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- 2012
30. Resting-state brain connectivity in patients with Parkinson's disease and freezing of gait
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Marina Picillo, Mario Cirillo, Gioacchino Tedeschi, Antonio Russo, Fabrizio Esposito, Carmine Vitale, Marianna Amboni, Paolo Barone, Alessandro Tessitore, Laura Marcuccio, Maria Teresa Pellecchia, Tessitore, Alessandro, Amboni, M, Esposito, F, Russo, Antonio, Picillo, M, Marcuccio, L, Pellecchia, Mt, Vitale, C, Cirillo, Mario, Tedeschi, Gioacchino, and Barone, P.
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Male ,medicine.medical_specialty ,Parkinson's disease ,Brain mapping ,Angular gyrus ,Physical medicine and rehabilitation ,Gait (human) ,Gyrus ,Parietal Lobe ,Neural Pathways ,medicine ,Humans ,Resting-state fMRI ,Gait Disorders, Neurologic ,Aged ,Parkinson’s disease ,Freezing of gait ,Brain Mapping ,medicine.diagnostic_test ,Resting state fMRI ,Functional Neuroimaging ,Magnetic resonance imaging ,Parkinson Disease ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Frontal Lobe ,medicine.anatomical_structure ,Neurology ,Case-Control Studies ,Female ,Neurology (clinical) ,Occipital Lobe ,Geriatrics and Gerontology ,Psychology ,Functional magnetic resonance imaging ,Neuroscience ,human activities - Abstract
Freezing of gait is a common cause of disability and falls in patients with Parkinson's disease. We studied brain functional connectivity, by means of resting-state functional magnetic resonance imaging, in patients with Parkinson's disease and freezing of gait.Resting-state functional magnetic resonance imaging at 3 T was collected in 29 patients with Parkinson's disease, of whom 16 presented with freezing of gait as determined by a validated freezing of gait questionnaire, and 15 matched healthy controls. Single-subject and group-level independent component analysis was used to identify the main resting-state networks differing between Parkinson's disease patients with and without freezing of gait. Statistical analysis was performed using BrainVoyager QX.Between-group differences in resting-state networks revealed that patients with freezing of gait exhibit significantly reduced functional connectivity within both "executive-attention" (in the right middle frontal gyrus and in the angular gyrus) and visual networks (in the right occipito-temporal gyrus) [p0.05 corrected for multiple comparisons]. Freezing of gait clinical severity was significantly correlated with decreased connectivity within the two networks. Consistent with their "executive-attention" network impairment, patients with freezing of gait scored lower on tests of frontal lobe functions (phonemic verbal fluency: p = 0.005; frontal assessment battery: p0.001; ten point clock test: p = 0.04).Our findings suggest that a resting-state functional connectivity disruption of "executive-attention" and visual neural networks may be associated with the development of freezing of gait in patients with Parkinson's disease.
- Published
- 2012
31. Hemiparkinsonism and hemiatrophy syndrome: A rare observation
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Alessandro Tessitore, Mario Cirillo, Gioacchino Tedeschi, Laura Marcuccio, Antonio Russo, Alfonso Giordano, Tessitore, Alessandro, Russo, Antonio, Cirillo, Mario, Giordano, A, Marcuccio, L, and Tedeschi, Gioacchino
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Pathology ,medicine.medical_specialty ,Pediatrics ,Dystonic posturing ,Functional Laterality ,Atrophy ,Fluorodeoxyglucose F18 ,Hemiatrophy ,Medicine ,Humans ,Gait disorders ,Gait Disorders, Neurologic ,Early onset ,Brain Chemistry ,Neurologic Examination ,Tomography, Emission-Computed, Single-Photon ,Dopamine Plasma Membrane Transport Proteins ,Muscle Weakness ,business.industry ,Parkinsonism ,Parkinson Disease ,General Medicine ,Middle Aged ,medicine.disease ,Dystonia ,Surgery ,Female ,Neurology (clinical) ,Skeletal abnormalities ,Radiopharmaceuticals ,business - Abstract
Hemiparkinsonism with hemiatrophy syndrome is defined by the occurrence of a body hemiatrophy with features of an early onset, slowly progressive, asymmetric parkinsonism more prominent on the side of the hemiatrophy. The underlying pathogenesis is not well understood but perinatal cerebral insults seem to play a crucial role. We describe the case of a 52-year-old woman who presented with a two year history of slowness and stiffness of left arm and leg with dystonic posturing of the ipsilateral hand. When examined, she had a left body hemiatrophy which was present since early childhood. Clinical and imaging findings supported the diagnosis of hemiparkinsonism with hemiatrophy syndrome with a good response to dopamine agonist therapy. This case report further characterizes this heterogeneous form of parkinsonism which deserves attention for clinical management and prognostic evaluation.
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- 2010
32. O021. Abnormal connectivity within executive resting-state network in migraine with aura
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Fabrizio Esposito, Alessandro Tessitore, Francesca Conte, Laura Marcuccio, Manuela De Stefano, Antonio Russo, Alfonso Giordano, Mario Cirillo, Gioacchino Tedeschi, Russo, A., Conte, F., Marcuccio, L., Esposito, F., Giordano, A., De Stefano, M., Cirillo, M., Tessitore, A., Tedeschi, G., Vision, and RS: FPN CN 1
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medicine.diagnostic_test ,Resting state fMRI ,Aura ,business.industry ,Clinical Neurology ,Context (language use) ,General Medicine ,medicine.disease ,Executive functions ,Migraine with aura ,Anesthesiology and Pain Medicine ,Migraine ,medicine ,Oral Presentation ,Neurology (clinical) ,medicine.symptom ,Functional magnetic resonance imaging ,business ,Neuroscience ,Executive dysfunction - Abstract
Background Despite the fact that the clinical features of migraine are well described, the relationship between migraine and cognitive performance is still poorly understood. Indeed, some authors have reported the presence of cognitive deficits in patients with migraine without aura (MwoA) and with aura (MwA) whereas others have not confirmed these findings. Although neuropsychological studies in migraine are not conclusive, the most likely pattern of neuropsychological impairment would relate to the cognitive domain of executive functions (EF) [1]. Recent imaging studies have shown a significant functional connectivity decrease within the fronto-parietal networks (FPN), known to be associated with EF, in patients with MwoA in absence of significant executive dysfunction [2]. Objective To further explore FPN functional connectivity in patients with MwA and patients with MwoA, in the interictal period. Methods Using resting-state functional magnetic resonance imaging (RS-fMRI), we compared functional connectivity within the FPN in 20 patients with MwA, versus 20 sex- and agematched healthy controls (HC). To examine the specificity of any observed differences in FPN functional connectivity between patients and HC, we further studied 20 age- and sex-matched patients with MwoA. Furthermore, we assessed the correlation between functional connectivity within FPN and EF in both migraine groups. Finally, we used voxel-based morphometry to assess whether between-group differences in functional connectivity were dependent on structural differences. Results Neuropsychological data revealed no significant executive dysfunction in both migraine groups compared to HC. RS-fMRI showed that both MwA and MwoA patients, compared to HC, had a significant functional connectivity decrease within the right FPN and specifically in the middle frontal gyrus and the dorsal anterior cingulate cortex. There were no structural differences between the three groups. Conclusions Our data demonstrate that, even in the absence of clinically evident EF deficits, MwA and MwoA are associated with reduced FPN functional connectivity. We suggest that disrupted FPN functional connectivity might be only a part of a complex cascade that terminates in a migraine attack. In this context, FPN abnormalities may be the neuronal substrate on which biological, genetic and environmental factors could induce, and in turn correlate with, migraine attacks mostly characterized by high pain intensity in patients with MwoA and aura phenomenon in patients with MwA. In other terms, observed FPN connectivity changes may represent a migraine biomarker, probably related to well-known maladaptive stress response in migraine patients. Written informed consent to publish was obtained from the patient(s).
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33. Family caregivers improve the diagnostic accuracy of disorders of consciousness: from remote to near-bed auditory stimulation.
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Moretta P, Femiano C, Cavallo ND, Lanzillo A, Luciano F, Ferrante C, Maiorino A, Santangelo G, and Marcuccio L
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- Humans, Middle Aged, Acoustic Stimulation, Cross-Sectional Studies, Consciousness physiology, Coma, Persistent Vegetative State diagnosis, Caregivers, Consciousness Disorders diagnosis
- Abstract
Background: Family caregivers (FC) contribute to reducing the misdiagnosis rate in patients with disorders of consciousness (DOC). Unfortunately, the recent pandemic of COVID-19 imposed drastic restrictions that limited the access of FC to the sensory/cognitive stimulation protocols. Telemedicine approaches have been implemented to avoid discontinuity in care pathways and to ensure caregivers involvement in rehabilitation programs., Aim: The aim was to investigate whether the presence of FC remotely connected might help clinicians in eliciting higher cortically mediated behavioral responses in patients with DOC., Design: Cross-sectional study., Setting: Post-acute Unit of Neurorehabilitation., Population: DOC due to severe brain injury., Methods: Consecutive patients with DOC were assessed by means of the Coma Recovery Scale-Revised (CRS-R) by two expert examiners. Each patient underwent to five assessments in two weeks in three different conditions: 1) by the examiner only (standard); 2) with the verbal stimulation given by the FC remotely connected by PC tablet (caregiver in remote); and 3) with the verbal stimulation given by the FC physically present (caregiver in presence)., Results: Thirty patients with DOC (VS/UWS=10; MCS=20; mean age: 51, range: 21-79; vascular: 16; anoxic: 6; TBI=8) and their FC were enrolled. Higher total scores of CRS-R were recorded both in "caregiver in remote" and in "caregiver in presence" than in standard condition (standard vs. remote, Z=2.942, P=0.003; standard vs. presence, Z=3.736, P<0.001). Furthermore, the administration of the CRS-R with a FC, elicited higher levels of behavioral responses in MCS patients, than CRS-R performed in standard condition. In particular, 2 patients out of 30 (6.66%) showed higher scores and better diagnosis when the CRS-R was administered with FC in remote. Similarly, 5 out of 30 patients (16.66%) showed better diagnoses when the CRS-R was administered with FC in presence. Five patients changed diagnosis between standard and presence conditions (3 MCS- were diagnosed as MCS+; 2 MCS+ were diagnosed as conscious)., Conclusions: Our findings add new evidence regarding the beneficial role of family members in the diagnosis of DOC, even mediated by telemedicine approach., Clinical Rehabilitation Impact: In future guidelines, FC should have an active and supporting role in the diagnostic and rehabilitative process of DOC.
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- 2024
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34. Visual vertical neglect in acquired brain injury: a systematic review.
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Moretta P, Cavallo ND, Fonzo E, Maiorino A, Ferrante C, Ambrosino P, Femiano C, Santangelo G, and Marcuccio L
- Abstract
Vertical neglect represents a visuospatial deficit occurring as a possible consequence of acquired brain injury (ABI). Differently from unilateral spatial neglect on horizontal space, vertical neglect is poorly studied in the literature and rarely assessed in clinical practice. In the available studies, the terms "radial," "vertical," and "altitudinal" neglect are often used interchangeably, although they do not describe the same spatial dimension. "Altitudinal" and "vertical" refer to the sagittal plane, whereas "radial" refers to the transverse plane. The term "vertical" is sometimes used interchangeably with respect to both axes. The aim of this systematic review was to identify the main characteristics of vertical neglect after ABI, the diagnostic tools used, and the treatment options. We also proposed a clarification of the manifestations and characteristics of vertical and radial neglect. The 23 articles reviewed, showed that the vertical neglect occurred more frequently on the lower space than on the upper space, that its presence was associated with horizontal neglect, and that it could also occur with compromise of the radial space, with the near radial being more common. The most frequent etiology associated with vertical neglect is vascular, particularly ischaemic. The lesions side are very heterogeneous and include both cortical and subcortical areas and all lobes, although the temporal lobe is most affected. With regard to the assessment tools, paper and pencil tasks are the most commonly used diagnostic tools to identify vertical neglect, although in recent years the use of computer-based tasks increased. Taken together, our results suggest that vertical neglect may be underestimated in patients with right hemisphere lesions and should always be assessed, especially in cases where the patient shows signs of horizontal neglect. The clinical assessment of vertical neglect is very important since it can lead to important functional limitations in everyday life, such as poor wheelchair handling, stumbling over unnoticed obstacles located below (or above), walking down stairs, taking off shoes., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Moretta, Cavallo, Fonzo, Maiorino, Ferrante, Ambrosino, Femiano, Santangelo and Marcuccio.)
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- 2024
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35. Free Thyroxine (fT4) as a Potential Biomarker of Neurological and Functional Outcome in Acquired Brain Injury: A Prospective Multicenter Cohort Study.
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Mele C, Bagnato S, De Tanti A, Lucca LF, Saviola D, Marcuccio L, Moretta P, Scarponi F, Losavio E, Picciola E, and Pingue V
- Abstract
The potential involvement of thyroid hormones (THs) in the neurological and functional recovery of patients with brain damage has been hypothesized. We aimed at investigating the role of THs and their variations during the rehabilitation process as predictive biomarkers of neurological and functional outcome in patients with acquired brain injury (ABI). This prospective, multicenter cohort study included 220 patients with ABI consecutively admitted for a 6-month neurorehabilitation program. Data on the etiology of the brain injury, occurrence of seizures, neurosurgical procedures, and death during hospitalization were collected. Both at the baseline (T0) and at the end of the rehabilitation process (T1), the following variables were evaluated: thyroid function (TSH, fT4, and fT3) and outcome measure including the Glasgow Coma Scale (GCS), Glasgow Outcome Scale-Extended (GOS-E), and Functional Independence Measure (FIM) scale. During neurorehabilitation, a significant decrease in fT4 levels was documented in the population as a whole and in patients with severe ABI ( p < 0.0001), whereas no significant variations were found in TSH and fT3 levels. No significant associations were found between THs and seizure occurrence, while the neurological and functional outcomes were associated with the variation in fT4 levels during rehabilitation. In particular, a higher magnitude of decrease in fT4 levels emerged as an independent predictor of more severe neurological damage (OR = 3.48, CI 95% 1.04-11.69, p = 0.04) and a lower functional recovery (β = -0.22, p = 0.01). In conclusion, serum fT4 variation during neurorehabilitation could represent a potential biomarker of neurological and functional outcome in patients with ABI. Further studies are needed to investigate the mechanisms underlying this association.
- Published
- 2023
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36. Cognitive impairment is associated with gait variability and fall risk in amyotrophic lateral sclerosis.
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Dubbioso R, Spisto M, Hausdorff JM, Aceto G, Iuzzolino VV, Senerchia G, De Marco S, Marcuccio L, Femiano C, Iodice R, Salvatore E, Santangelo G, Trojano L, and Moretta P
- Subjects
- Humans, Gait, Walking, Cognition, Amyotrophic Lateral Sclerosis complications, Cognitive Dysfunction complications
- Abstract
Background: In amyotrophic lateral sclerosis (ALS), gait abnormalities contribute to poor mobility and represent a relevant risk for falls. To date, gait studies in ALS patients have focused on the motor dimension of the disease, underestimating the cognitive aspects., Methods: Using a wearable gait analysis device, we compared gait patterns in ambulatory ALS patients with mild cognitive impairment (ALS MCI+; n = 18), and without MCI (ALS MCI-; n = 24), and healthy subjects (HS; n = 16) under two conditions: (1) normal gait (single task) and (2) walking while counting backward (dual task). Finally, we examined if the occurrence and number of falls in the 3 months following the baseline test were related to cognition., Results: In the single task condition, ALS patients, regardless of cognition, displayed higher gait variability than HS, especially for stance and swing time (p < 0.001). The dual task condition revealed additional differences in gait variability parameters between ALS MCI+ and ALS MCI- for cadence (p = 0.005), stance time (p = 0.04), swing time (p = 0.04) and stability index (p = 0.02). Moreover, ALS MCI+ showed a higher occurrence (p = 0.001) and number of falls (p < 0.001) at the follow-up. Regression analyses demonstrated that MCI condition predicted the occurrence of future falls (β = 3.649; p = 0.01) and, together with executive dysfunction, was associated with the number of falls (cognitive impairment: β = 0.63; p < 0.001; executive dysfunction: β = 0.39; p = 0.03), regardless of motor impairment at clinical examination., Conclusion: In ALS, MCI is associated with exaggerated gait variability and predicts the occurrence and number of short-term falls., (© 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.)
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- 2023
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37. Cardiac and Pulmonary Rehabilitation: Two Underutilized Approaches with Some Unexpected Benefits.
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Ambrosino P, Marcuccio G, Formisano R, Marcuccio L, Filosa R, and Maniscalco M
- Abstract
Although still underutilized [...].
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- 2023
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38. Thyrotropic Axis and Disorders of Consciousness in Acquired Brain Injury: A Potential Intriguing Association?
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Mele C, De Tanti A, Bagnato S, Lucca LF, Saviola D, Estraneo A, Moretta P, Marcuccio L, Lanzillo B, Aimaretti G, Nardone A, Marzullo P, and Pingue V
- Subjects
- Cohort Studies, Consciousness, Humans, Retrospective Studies, Thyrotropin, Treatment Outcome, Brain Injuries complications, Brain Injuries rehabilitation, Consciousness Disorders complications, Consciousness Disorders rehabilitation
- Abstract
Purpose: A potential involvement of thyrotropic axis in influencing the state of consciousness could be hypothesized. We aimed at investigating thyroid function tests as predictors of disorders of consciousness (DoC) and relating recovery in a large cohort of patients with DoC secondary to acquired brain injury (ABI)., Methods: This retrospective, multicenter, cohort study included 151 patients with DoC following ABI, consecutively admitted for a 6-month neurorehabilitation program. Data on etiology of brain injury, evolution of DoC, disability and rehabilitation assessments, and death during rehabilitation were collected at baseline and on discharge. Thyroid function tests (serum TSH, fT4 and fT3 levels) were assessed on admission in all patients and at final discharge in 50 patients., Results: Lower baseline TSH levels and greater TSH increments (ΔTSH) after neurorehabilitation predicted a favorable change in DoC independent of age, sex, BMI, etiology of brain injury and initial DoC subtype (TSH: OR=0.712, CI 95% 0.533-0.951, p=0.01; ΔTSH: OR=2.878, CI 95% 1.147-7.223, p=0.02). On the other hand, neither fT4 nor fT3 or their variations appeared to play any role on DoC changes after 6-months inpatient neurorehabilitation. A lower magnitude of ΔfT4 acted as a strong predictor of improved functional disability level (β=0.655, p=0.002) and cognitive functions (β=-0.671, p=0.003), implying that smaller changes in fT4 were associated with higher outcomes., Conclusions: Serum TSH levels assessed in the subacute post-ABI phase and its variation during neurorehabilitation could represent a potential biomarker of DoC evolution, while variations in fT4 levels seem to be associated with rehabilitation and cognitive functions. Further studies are needed to investigate the mechanisms underlying these associations., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Mele, De Tanti, Bagnato, Lucca, Saviola, Estraneo, Moretta, Marcuccio, Lanzillo, Aimaretti, Nardone, Marzullo and Pingue.)
- Published
- 2022
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39. Cognitive Impairment in Convalescent COVID-19 Patients Undergoing Multidisciplinary Rehabilitation: The Association with the Clinical and Functional Status.
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Moretta P, Ambrosino P, Lanzillo A, Marcuccio L, Fuschillo S, Papa A, Santangelo G, Trojano L, and Maniscalco M
- Abstract
Background: Cognitive impairment has been reported in the aftermath of severe acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) infection. We investigated the possible association between cognitive impairment and the main clinical and functional status variables in a cohort of convalescent COVID-19 patients without premorbid diseases potentially affecting cognition., Methods: We consecutively screened for inclusion of convalescent COVID-19 patients referring to a post-acute care facility for pulmonary rehabilitation. All the enrolled patients were assessed for cognitive functions. We also investigated features of psychological distress (anxiety, depression, symptoms of posttraumatic stress disorder and quality of life) and cardiac and pulmonary functional status., Results: The 63 enrolled patients (mean age 59.82 ± 10.78, male gender = 47) showed a high frequency of depressive symptoms (76.2%) and anxiety (55.5%), and a high prevalence of symptoms of posttraumatic stress disorder (PTSD, 44.4%). About half of the total sample showed reduced cognitive efficiency (RCE, 44.4%) in the domains of spatial and verbal long-term memory and executive functions. Patients with RCE more frequently showed alteration of blood pressure (BP) circadian rhythm ( p = 0.01), higher levels of D-Dimer ( p = 0.03), had experienced a severe illness ( p = 0.02), had longer disease duration ( p = 0.04), more clinically relevant symptoms of PTSD ( p = 0.02), more frequent cognitive complaints ( p = 0.002), higher anxiety scores ( p = 0.01) and lower quality of life ( p = 0.02) than patients with normal cognitive efficiency., Conclusions: Our findings indicated a possible association between the RCE after COVID-19 and some cardiological variables, including some indirect measures of a residual autonomic disorder, such as the presence of an altered BP circadian rhythm. Future research studies with large samples are needed to provide valid conclusions.
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- 2022
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40. Prognosis of severe acquired brain injury: Short and long-term outcome determinants and their potential clinical relevance after rehabilitation. A comprehensive approach to analyze cohort studies.
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Lanzillo B, Piscosquito G, Marcuccio L, Lanzillo A, and Vitale DF
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- Adult, Aged, Brain Injuries epidemiology, Brain Injuries rehabilitation, Cohort Studies, Female, Humans, Male, Middle Aged, Neurological Rehabilitation statistics & numerical data, Prognosis, Proportional Hazards Models, Brain Injuries diagnosis
- Abstract
Background: Accurate prognostic evaluation is a key factor in the clinical management of patients affected by severe acute brain injury (ABI) and helps planning focused therapies, better caregiver's support and allocation of resources. Aim of the study was to assess factors independently associated with both the short and long-term outcomes after rehabilitation in patients affected by ABI in the setting of a single Rehabilitation Unit specifically allocated to these patients., Methods and Findings: In all patients (567) with age ≥ 18 years discharged from the Unit in the period 2006/2015 demographic, etiologic, comorbidity indicators, and descriptors of the disability burden (at hospital admission and discharge) were evaluated as potential prognostic factors of both short-term (4 classes of disability status at discharge) and long-term (mortality) outcomes. A comprehensive analytical method was adopted to combine several tasks. Select the factors with a significant independent association with the outcome, assess the relative weights and the "stability" (by bootstrap resampling) of them and estimate the role of the prognostic models in the clinical framework considering "cost" and "benefits". The generalized ordered logistic model for ordinal dependent variables was used for the short-term outcome while the Cox proportional hazard model was used for the long-term outcome. The final short-term model identified 7 factors that independently account for 37% of the outcome variability as shown by pseudo R2 (pR2) = 0.37. The disability status descriptors show the strongest association since they account for more than 60% of the pR2, followed by age (14.8%), the presence of percutaneous endoscopic gastrostomy or nasogastric intubation (14.4%), a longer stay in the acute ward (5.9%) and concomitant coronary disease (1.3%). The final multivariable Cox model identified 4 factors that independently account for 52% of the outcome variability (R2 = 0.52). The disability extent and the disability recovered lead the long-term mortality since they account for the 53% of the global R2. The relevant effect of age (42%) is appreciable only after 2 years given the significant interaction with time. A longer stay in the acute ward explains the remaining fraction (5%). Considering 'cost and benefits', the decision curve analysis shows that the clinical benefit achieved by using both prognostic models is greater than the other possible action strategies, namely 'treat all' and 'treat none. Several less obvious characteristics of the prognostic models are appreciated by integrating the results of multiple analytical methods., Conclusion: The comprehensive analytical tool aimed to integrate statistical significance, weight, "stability" and clinical "net" benefit, gives back a prognostic framework explaining a relevant portion of both outcomes' variability in which the strong association of the disability status with both outcomes is comparable to and followed by a time modulated role of age. Our data do not support a differentiated association of traumatic vs non-traumatic etiology. The results encourage the use of integrated approach to analyze cohort data., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2019
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41. Prospective memory is dysfunctional in migraine without aura.
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Santangelo G, Russo A, Tessitore A, Garramone F, Silvestro M, Della Mura MR, Marcuccio L, Fornaro I, Trojano L, and Tedeschi G
- Subjects
- Adult, Female, Humans, Male, Middle Aged, Memory Disorders epidemiology, Memory Disorders etiology, Migraine without Aura complications
- Abstract
Introduction Prospective memory is the ability to carry out a delayed intended action, so to maintain and retrieve future plans, goals and activities. Deficits of prospective memory negatively impact on patients and caregivers' everyday living and determine poor adherence to treatment. Since frontal regions are involved in both event- and time-based prospective memory tasks and are impaired in migraine without aura, defects of prospective memory might occur in migraine without aura patients; until now this issue has not been investigated. The aim of the current study was to explore time- versus event-based prospective memory in migraine without aura. Patients and methods Ninty-one consecutive migraine without aura patients and 84 healthy subjects were enrolled in the study. They underwent a standardized measure of prospective memory evaluating both time-based and event-based prospective memory, and the Montreal Cognitive Assessment assessing global cognitive status. Moreover, all participants completed the Beck Depression Inventory-II and a self-administered version of the Apathy Evaluation Scale, to assess severity of depressive symptoms and apathy, respectively. Results Migraine without aura and healthy subjects did not differ on demographic aspects (i.e. age, education and gender). However, individuals with migraine without aura demonstrated impaired prospective memory performance compared to healthy subjects, with a greater impairment demonstrated for the time-based tasks. Within the migraine without aura group, no significant association was found between prospective memory performance and clinical scores, apathy, and depression. Conclusions Individuals with migraine without aura experience particular difficulty executing a future intention; therefore, migraine without aura is associated with dysfunction of prospective memory.
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- 2018
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42. Migraine Does Not Affect Pain Intensity Perception: A Cross-Sectional Study.
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Russo A, Tessitore A, Bruno A, Siciliano M, Marcuccio L, Silvestro M, and Tedeschi G
- Subjects
- Adult, Cross-Sectional Studies, Female, Humans, Hyperalgesia physiopathology, Male, Migraine Disorders physiopathology, Pain Perception physiology, Pain Threshold physiology
- Abstract
Objective: To explore perceived pain intensity (PPI) in three drug-naïve patient groups characterized by homogeneous migraine phenotypes-migraine without aura without cutaneous allodynia (MwoA CA-), MwoA with ictal CA (MwoA CA+), and migraine with aura without cutaneous allodynia (MwA CA-)-compared with age- and sex-matched healthy controls (HCs)., Methods: Using trigeminal heat stimulation (THS) at three different predefined intensities (41 °C, 51 °C, and 53 °C) performed by the contact heat-evoked potential stimulator (CHEPS), PPI was investigated in 34 patients with MwoA CA-, 30 patients with MwoA CA+, and 30 patients with MwA CA- compared with 30 age- and sex-matched HCs. The patients had never taken migraine-preventive drugs, and they were investigated during an interictal period to avoid confounds associated with migraine attack. Secondary analyses evaluated associations between PPI and clinical features of migraine in patients., Results: No significant differences were observed between the four groups for each experimentally induced stimulus. Moreover, no significant correlations were found between clinical variables and the PPI of the THS at any level of experimental stimulus., Conclusions: Despite the converging evidence of pain threshold abnormalities in migraine patients, our findings suggest that migraine patients did not exhibit differences in the PPI of THS when compared with HCs, independent of phenotype and migraine severity, as well as somatic, psychiatric, or pharmacological interferences. This may depend on both the nature of the pain stimulus experienced and the involvement of selective regions or specific pain processing pathways.
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- 2018
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43. Functional Changes of the Perigenual Part of the Anterior Cingulate Cortex after External Trigeminal Neurostimulation in Migraine Patients.
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Russo A, Tessitore A, Esposito F, Di Nardo F, Silvestro M, Trojsi F, De Micco R, Marcuccio L, Schoenen J, and Tedeschi G
- Abstract
Objective: To explore the functional reorganization of the pain processing network during trigeminal heat stimulation (THS) after 60 days of external trigeminal neurostimulation (eTNS) in migraine without aura (MwoA) patients between attacks., Methods: Using whole-brain BOLD-fMRI, functional response to THS at two different intensities (41 and 51°C) was investigated interictally in 16 adults MwoA patients before and after eTNS with the Cefaly
® device. We calculated the percentage of patients having at least a 50% reduction of monthly migraine attacks and migraine days between baseline and the last month of eTNS. Secondary analyses evaluated associations between BOLD signal changes and clinical features of migraine., Results: Before eTNS treatment, there was no difference in BOLD response between MwoA patients and healthy controls (HC) during low-innocuous THS at 41°C, whereas the perigenual part of the right anterior cingulate cortex (ACC) revealed a greater BOLD response to noxious THS at 51°C in MwoA patients when compared to HC. The same area demonstrated a significant reduced BOLD response induced by the noxious THS in MwoA patients after eTNS ( p = 0.008). Correlation analyses showed a significant positive correlation between ACC BOLD response to noxious THS before eTNS treatment and the decrease of ACC BOLD response to noxious THS after eTNS. Moreover, a significant negative correlation in the migraine group after eTNS treatment between ACC functional activity changes and both the perceived pain ratings during noxious THS and pre-treatment migraine attack frequency has been found., Conclusion: Our findings suggest that eTNS treatment with the Cefaly® device induces a functional antinociceptive modulation in the ACC that is involved in the mechanisms underlying its preventive anti-migraine efficacy. Nevertheless, further observations to confirm whether the observed fMRI effects of eTNS are both related to clinical improvement and specific to antinociceptive modulation in migraine patients are mandatory.- Published
- 2017
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44. Functional interictal changes of pain processing in migraine with ictal cutaneous allodynia.
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Russo A, Esposito F, Conte F, Fratello M, Caiazzo G, Marcuccio L, Giordano A, Tedeschi G, and Tessitore A
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- Adult, Brain physiopathology, Brain Mapping, Female, Hot Temperature, Humans, Magnetic Resonance Imaging, Male, Prospective Studies, Hyperalgesia physiopathology, Migraine Disorders physiopathology, Pain physiopathology
- Abstract
Objective A prospective clinical imaging study has been conducted to investigate pain processing functional pathways during trigeminal heat stimulation (THS) in patients with migraine without aura experiencing ictal cutaneous allodynia (CA) (MwoA CA+). Methods Using whole-brain BOLD-fMRI, functional response to THS at three different intensities (41°, 51° and 53℃) was investigated interictally in 20 adult MwoA CA+ patients compared with 20 MwoA patients without ictal CA (MwoA CA-) and 20 healthy controls (HCs). Secondary analyses evaluated associations between BOLD signal change and clinical features of migraine. Results During moderate-noxious THS (51℃), we observed a significantly greater activation in (a) the anterior cingulate cortex in MwoA CA+ patients compared to HCs and (b) the middle frontal gyrus in MwoA CA+ patients compared to both MwoA CA- patients and HCs. Furthermore, during high-noxious THS (53℃) a significantly decreased activation in the secondary somatosensory cortices was observed in (a) MwoA CA- patients compared to both MwoA CA+ patients and HCs and (b) MwoA CA+ patients compared to HCs. CA severity was positively correlated with the secondary somatosensory cortices activation. Conclusions Our findings suggest that CA may be subtended by both a dysfunctional analgesic compensatory mechanism and an abnormal internal representation of pain in migraine patients.
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- 2017
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45. Cognitive dysfunctions and psychological symptoms in migraine without aura: a cross-sectional study.
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Santangelo G, Russo A, Trojano L, Falco F, Marcuccio L, Siciliano M, Conte F, Garramone F, Tessitore A, and Tedeschi G
- Subjects
- Adult, Aged, Anxiety etiology, Cognitive Dysfunction epidemiology, Cognitive Dysfunction psychology, Cross-Sectional Studies, Depression etiology, Disability Evaluation, Female, Humans, Italy epidemiology, Male, Middle Aged, Migraine without Aura epidemiology, Psychiatric Status Rating Scales, Cognitive Dysfunction etiology, Migraine without Aura psychology
- Abstract
Background: The occurrence of cognitive dysfunctions and psychological symptoms, as well as their mutual relationships, in migraine patients are still debated. The aim of the study was to characterize the cognitive profile and psychological symptoms (i.e. depression, anxiety and apathy) in drug-naïve migraine without aura (MwoA) patients., Methods: Seventy-two consecutive MwoA patients, referred to the Italian University Headache Clinic and 72 healthy subjects (HCs) were enrolled. Patients, during an attack-free period, and HCs completed Montreal Cognitive Assessment (MoCA), Beck Depression Inventory-II (BDI-II), Self-version of Apathy Evaluation Scale (AES-S) and State and Trait Anxiety Inventory (STAI-Y-1 and 2). Clinical parameters of disease severity (i.e. disease duration, migraine attacks per month, mean pain intensity during migraine attacks, migraine disability and impact on daily life) were recorded., Results: Although performance of MwoA patients on MoCA was above Italian cut-off threshold (<15.5) suggesting presence of cognitive impairment, MwoA patients achieved significantly lower scores than HCs on total MoCA scale (22.3 ± 2.7 versus 25.4 ± 2.3) and on its attention (4.9 ± 1.1 versus 5.6 ± 0.7), memory (1.8 ± 1.4 versus 3.1 ± 1.3), visuospatial (3.2 ± 0.9 versus 3.6 ± 0.6) and executive subscales (2.6 ± 1.1 versus 3.1 ± 0.8). In addition, we observed significant correlations between MoCA executive domain subscore and the attack-related disability score (MIDAS). As for behavioral profile, the percentage of depressive symptoms (4.2 %), high state and trait anxiety (13.9 and 9.7 %, respectively), and apathy (11.1 %) in MwoA patients were similar to that of HCs. No significant associations of behavioural symptoms with cognitive performance and clinical parameters were found., Conclusions: Drug-naïve MwoA patients are characterized by subtle cognitive dysfunctions and low percentage of behavioural symptoms. The results support the importance of searching for subclinical cognitive disturbances in patients with MwoA, who deserve to be followed-up to verify whether they develop clinically relevant disorders over time.
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- 2016
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46. P020. No evidence of microstructural changes in visual network in patients with migraine with aura: a diffusion tensor tract-based spatial statistic (TBSS) study.
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Russo A, Conte F, Marcuccio L, Corbo D, Caiazzo G, Giordano A, Conforti R, Esposito F, Tessitore A, and Tedeschi G
- Published
- 2015
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47. O020. Dysfunctional analgesic mechanisms in migraine patients with ictal cutaneous allodynia.
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Russo A, Esposito F, Conte F, Marcuccio L, Fratello M, Caiazzo G, Giordano A, Conforti R, Tessitore A, and Tedeschi G
- Published
- 2015
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48. P019. Transcutaneous supraorbital neurostimulation in "de novo" patients with migraine without aura: the first Italian experience.
- Author
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Russo A, Conte F, Marcuccio L, Giordano A, Tedeschi G, and Tessitore A
- Published
- 2015
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49. P018. No evidence of microstructural changes in patients with vestibular migraine: a diffusion tensor tract based spatial statistic (TBSS) study.
- Author
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Russo A, Marcuccio L, Conte F, Caiazzo G, Giordano A, Conforti R, Esposito F, Tedeschi G, and Tessitore A
- Published
- 2015
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50. O021. Abnormal connectivity within executive resting-state network in migraine with aura.
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Russo A, Conte F, Marcuccio L, Esposito F, Giordano A, De Stefano M, Cirillo M, Tessitore A, and Tedeschi G
- Published
- 2015
- Full Text
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