97 results on '"Mariangela Tosca"'
Search Results
2. Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases
- Author
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Marzia Duse, Francesca Santamaria, Maria Carmen Verga, Marcello Bergamini, Giovanni Simeone, Lucia Leonardi, Giovanna Tezza, Annamaria Bianchi, Annalisa Capuano, Fabio Cardinale, Giovanni Cerimoniale, Massimo Landi, Monica Malventano, Mariangela Tosca, Attilio Varricchio, Anna Maria Zicari, Carlo Alfaro, Salvatore Barberi, Paolo Becherucci, Roberto Bernardini, Paolo Biasci, Carlo Caffarelli, Valeria Caldarelli, Carlo Capristo, Serenella Castronuovo, Elena Chiappini, Renato Cutrera, Giovanna De Castro, Luca De Franciscis, Fabio Decimo, Iride Dello Iacono, Lucia Diaferio, Maria Elisa Di Cicco, Caterina Di Mauro, Cristina Di Mauro, Dora Di Mauro, Francesco Di Mauro, Gabriella Di Mauro, Mattia Doria, Raffaele Falsaperla, Valentina Ferraro, Vassilios Fanos, Elena Galli, Daniele Giovanni Ghiglioni, Luciana Indinnimeo, Ahmad Kantar, Adima Lamborghini, Amelia Licari, Riccardo Lubrano, Stefano Luciani, Francesco Macrì, Gianluigi Marseglia, Alberto Giuseppe Martelli, Luigi Masini, Fabio Midulla, Domenico Minasi, Vito Leonardo Miniello, Michele Miraglia del Giudice, Sergio Renzo Morandini, Germana Nardini, Agostino Nocerino, Elio Novembre, Giovanni Battista Pajno, Francesco Paravati, Giorgio Piacentini, Cristina Piersantelli, Gabriella Pozzobon, Giampaolo Ricci, Valter Spanevello, Renato Turra, Stefania Zanconato, Melissa Borrelli, Alberto Villani, Giovanni Corsello, Giuseppe Di Mauro, and Diego Peroni
- Subjects
Inhaled corticosteroids ,Asthma ,Wheezing ,Rhinitis ,Rhinosinusitis ,Laryngospasm ,Pediatrics ,RJ1-570 - Abstract
Abstract Background In 2019, a multidisciplinary panel of experts from eight Italian scientific paediatric societies developed a consensus document for the use of inhaled corticosteroids in the management and prevention of the most common paediatric airways disorders. The aim is to provide healthcare providers with a multidisciplinary document including indications useful in the clinical practice. The consensus document was intended to be addressed to paediatricians who work in the Paediatric Divisions, the Primary Care Services and the Emergency Departments, as well as to Residents or PhD students, paediatric nurses and specialists or consultants in paediatric pulmonology, allergy, infectious diseases, and ear, nose, and throat medicine. Methods Clinical questions identifying Population, Intervention(s), Comparison and Outcome(s) were addressed by methodologists and a general agreement on the topics and the strength of the recommendations (according to the GRADE system) was obtained following the Delphi method. The literature selection included secondary sources such as evidence-based guidelines and systematic reviews and was integrated with primary studies subsequently published. Results The expert panel provided a number of recommendations on the use of inhaled corticosteroids in preschool wheezing, bronchial asthma, allergic and non-allergic rhinitis, acute and chronic rhinosinusitis, adenoid hypertrophy, laryngitis and laryngospasm. Conclusions We provided a multidisciplinary update on the current recommendations for the management and prevention of the most common paediatric airways disorders requiring inhaled corticosteroids, in order to share useful indications, identify gaps in knowledge and drive future research.
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- 2021
- Full Text
- View/download PDF
3. Inhaled corticosteroids use in childhood respiratory diseases: an italian survey on pediatricians’ prescription habits
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Giovanni Cerimoniale, Paolo Becherucci, Maria Carmen Verga, Giuseppe Di Mauro, Luciana Indinnimeo, Alberto Villani, Mariangela Tosca, Gian Luigi Marseglia, Marzia Duse, Paolo Biasci, Mattia Doria, Diego Peroni, Giorgio Piacentini, Maria Di Cicco, Gabriella Pozzobon, and Riccardo Lubrano
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Inhaled corticosteroids ,Allergic rhinitis ,Asthma ,Preschool wheezing ,Laryngitis ,Children ,Pediatrics ,RJ1-570 - Abstract
Abstract Background A national consensus document on inhaled corticosteroids (ICS) use in childhood, produced by the main Italian pediatric scientific societies, has been recently released. The aim of this study was to gather information on the current pediatricians’ ICS prescription habits in Italy for the management of the most common pediatric respiratory diseases, namely allergic rhinitis (AR), asthma, preschool wheezing and laryngitis. Methods From the 1st October 2018 to the 31st January 2019 a link to an online questionnaire was sent monthly through a newsletter to the members of the Italian Society of Pediatrics. The questionnaire included 18 items on ICS use in the most common pediatric respiratory diseases. Data collection and reporting was based on STROBE Statement Checklist for cross-sectional studies. Results One thousand-two questionnaires were returned from primary care pediatricians (39.1%), hospital pediatricians (38.7%), private practicers (16.4%), university pediatricians (3.1%) and Pediatrics residents (2.7%). We found a good adherence to the international guidelines on AR, with prevalent use of oral antihistamine (60.6%) in the secretive phenotype and nasal ICS in the obstructive phenotype (64.8%). In asthma exacerbations ICS are not used in 53.4% of cases, but they are used at high dose in 27.9% and at low dose in 18.7% of cases. In intermittent asthma, ICS are not chosen as a daily controller therapy in 54.1% of cases, while they are chosen as a low dose daily therapy in 44.5% of cases (high dose in 1.4%). In children with persistent asthma, ICS are chosen as a daily low dose therapy in 67.4% of cases and as a daily high dose therapy in 31%. In the management of preschool wheezing, when a long-term treatment is needed, ICS are chosen both alone and in association with antileukotrienes in 71.4% of cases. Children affected by recurrent asthma exacerbations and wheezing are closely followed up, in particular by their primary care pediatricians. The preference for certain molecules in the treatment of different respiratory diseases also emerged. Conclusions Pediatricians’ ICS prescription habits in Italy should be improved, especially in the management of asthma. Future surveys on a more numerous sample will be useful to analyze differences in prescription habits on the basis of pediatricians’ work settings and geographical distribution.
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- 2021
- Full Text
- View/download PDF
4. Correction: Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases
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Marzia Duse, Francesca Santamaria, Maria Carmen Verga, Marcello Bergamini, Giovanni Simeone, Lucia Leonardi, Giovanna Tezza, Annamaria Bianchi, Annalisa Capuano, Fabio Cardinale, Giovanni Cerimoniale, Massimo Landi, Monica Malventano, Mariangela Tosca, Attilio Varricchio, Anna Maria Zicari, Carlo Alfaro, Salvatore Barberi, Paolo Becherucci, Roberto Bernardini, Paolo Biasci, Carlo Caffarelli, Valeria Caldarelli, Carlo Capristo, Serenella Castronuovo, Elena Chiappini, Renato Cutrera, Giovanna De Castro, Luca De Franciscis, Fabio Decimo, Iride Dello Iacono, Lucia Diaferio, Maria Elisa Di Cicco, Caterina Di Mauro, Cristina Di Mauro, Dora Di Mauro, Francesco Di Mauro, Gabriella Di Mauro, Mattia Doria, Raffaele Falsaperla, Valentina Ferraro, Vassilios Fanos, Elena Galli, Daniele Giovanni Ghiglioni, Luciana Indinnimeo, Ahmad Kantar, Adima Lamborghini, Amelia Licari, Riccardo Lubrano, Stefano Luciani, Francesco Macrì, Gianluigi Marseglia, Alberto Giuseppe Martelli, Luigi Masini, Fabio Midulla, Domenico Minasi, Vito Leonardo Miniello, Michele Miraglia Del Giudice, Sergio Renzo Morandini, Germana Nardini, Agostino Nocerino, Elio Novembre, Giovanni Battista Pajno, Francesco Paravati, Giorgio Piacentini, Cristina Piersantelli, Gabriella Pozzobon, Giampaolo Ricci, Valter Spanevello, Renato Turra, Stefania Zanconato, Melissa Borrelli, Alberto Villani, Giovanni Corsello, Giuseppe Di Mauro, and Diego Peroni
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Pediatrics ,RJ1-570 - Published
- 2022
- Full Text
- View/download PDF
5. Anaphylactic Shock During Pediatric Anesthesia: An Unexpected Reaction to Sevoflurane
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Alessandro Simonini, Etrusca Brogi, Brunella Gily, Mariangela Tosca, Claudia Barbieri, Francesca Antonini, and Genny Del Zotto
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Sevoflurane ,anaphylaxis ,anaphylactic shock ,allergy ,perioperative complications ,pediatric anesthesia ,Pediatrics ,RJ1-570 - Abstract
During general anesthesia, while muscle relaxants, latex and antibiotics are normally considered as very common causes of anaphylactic reactions, there are no documented cases of anaphylaxis due to inhalational agents. We report the case of a 6-year-old child scheduled for adenotonsillectomy who had an anaphylactic shock reaction due to Sevoflurane. Several allergic tests were performed to detect the trigger. Drugs used during operation were tested on both patient and three matched controls. While controls were negative, the patient displayed a positive reaction to Sevoflurane. To our knowledge, this is the first published report describing an allergic reaction caused by a volatile anesthetic.
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- 2018
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6. Serotonin in Allergic Rhinitis: a Possible Role for Behavioural Symptoms
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Giorgio Ciprandi, Mara De Amici, Mariangela Tosca, Roberta Alesina, Gianluigi Marseglia, and Dietmar Fuchs
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Allergic Rhinitis ,Behavioral Symptoms ,Pollen Allergen Exposure ,Serum ,Serotonin ,Medicine - Abstract
Allergic rhinitis (AR) is a very frequent disease which is not only characterized by nasal symptoms, but also with behavioural changes. This study evaluated the serum serotonin levels in patients with pollen-induced AR during and outside the pollen season. One-hundred-two (56 females, 46 males, median age: 28.7 years) were included in this study: 56 with seasonal AR (SAR) evaluated outside the pollen season and so without allergic inflammation and symptoms, and 46 with SAR evaluated during the pollen season with symptoms. Blood specimens were collected to assess serum concentrations of serotonin and to compare results to scores of a Quality of Life (QoL) questionnaire which was performed in all subjects. Serotonin serum concentrations were higher in AR patients out of pollen season than in (p
- Published
- 2011
7. Respiratory comorbidities in severe asthma: focus on the pediatric age
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Amelia Licari, Beatrice Andrenacci, Maria Elisa Di Cicco, Maddalena Leone, Gian Luigi Marseglia, and Mariangela Tosca
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severe asthma ,Pulmonary and Respiratory Medicine ,Asthma comorbidities ,breathing pattern disorders ,bronchiectasis ,inducible laryngeal obstructions ,obstructive sleep apnea ,pediatrics ,rhinitis ,rhinosinusitis ,severe asthma with fungal sensitization ,Public Health, Environmental and Occupational Health ,Immunology and Allergy - Published
- 2023
- Full Text
- View/download PDF
8. [Beclomethasone dipropionate: efficacy and safety of the administration by nebulization.]
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Mariangela, Tosca and Giovanni A, Rossi
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Adrenal Cortex Hormones ,Administration, Inhalation ,Beclomethasone ,Humans ,Anti-Asthmatic Agents ,Asthma - Abstract
The advent of inhaled corticosteroids (ICS) brought a revolution in the management of asthma, representing now the cornerstone in this pathological condition treatment. Indeed, these drugs have clearly shown to possess a high degree of both efficacy and safety. Beclomethasone dipropionate (BDP) is the first molecule tested in the early 1970s. When administered via nebulizers or pressurized metered-dose inhalers (pMDI), BDP was found to be effective in reducing the symptoms frequency and severity in asthmatic patients, even in those previously treated with low-dose oral corticosteroids. The drug was thus produced to be administered by nebulization or via pMDI. Nebulizers are a practical and efficient tool for administering inhaled drugs in patients of all degree of severity and belonging to all ages, but are especially useful for those unable to utilize other inhaler devices correctly. BDP aerosolization, when generated by modern pneumatic nebulizers, can deliver particles with a mass median aerodynamic diameter (MMAD) value of 2.9-3.7 µm. This ability allows the deposition of the drug in small caliber airways, and considerably reduces the amount of drug deposited in the oropharynx, thus improving this molecule pharmacokinetics. This review aims to analyze the factors influencing the efficacy and safety of ICS, evaluating in detail the characteristics of BDP administered by nebulization.
- Published
- 2022
9. An update on the role of chronic rhinosinusitis with nasal polyps as a co-morbidity in severe asthma
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Mariangela Tosca, Gian Luigi Marseglia, Giorgio Ciprandi, Ilaria Brambilla, Riccardo Castagnoli, and Amelia Licari
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Chronic rhinosinusitis ,Severe asthma ,Comorbidity ,Severity of Illness Index ,Pathogenesis ,03 medical and health sciences ,Nasal Polyps ,0302 clinical medicine ,immune system diseases ,Prevalence ,otorhinolaryngologic diseases ,Humans ,Immunology and Allergy ,Medicine ,Nasal polyps ,030212 general & internal medicine ,Sinusitis ,Rhinitis ,Asthma ,business.industry ,Public Health, Environmental and Occupational Health ,medicine.disease ,Dermatology ,respiratory tract diseases ,Phenotype ,030228 respiratory system ,Chronic Disease ,Co morbidity ,business - Abstract
Chronic rhinosinusitis and asthma are heterogeneous diseases with complex pathogenesis. The presence of chronic rhinosinusitis with nasal polyps has been associated with increased asthma exacerbation frequency and may represent a predictor of future exacerbations in severe asthma.This review provides the clinician with an overview of the prevalence and clinical impact of the chronic rhinosinusitis with nasal polyps in severe asthma and summarizes recommended therapeutic approaches, including innovative biologic therapies. To select relevant literature for inclusion in this review, we conducted a literature search using the PubMed and ClinicalTrials.gov databases, using terms 'chronic rhinosinusitis with nasal polyps' AND 'asthma' OR 'severe asthma.' The literature review was performed for publication years 2010-2020, restricting the articles to humans and English language publications.Biological therapies have opened new perspectives in the treatment of upper and lower airway allergic diseases. Care pathways in severe asthma are almost consolidated, while they still rely on phenotypic rather than endotypic features in chronic rhinosinusitis with nasal polyps. Unveiling the correlation between clinical phenotypes and molecular endotypes will allow better stratification of patients with chronic rhinosinusitis with nasal polyps to identify candidates who benefit most from biological therapy.
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- 2020
- Full Text
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10. Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases
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Vassilios Fanos, Fabio Cardinale, Salvatore Barberi, Alberto Villani, Carlo Caffarelli, Giovanni Simeone, Elena Chiappini, Roberto Bernardini, Monica Malventano, Luca De Franciscis, Annalisa Capuano, Stefano Luciani, Renato Turra, Stefania Zanconato, Domenico Minasi, Paolo Becherucci, Annamaria Bianchi, Marzia Duse, Paolo Biasci, Marcello Bergamini, Francesca Santamaria, Giuseppe Di Mauro, Serenella Castronuovo, Adima Lamborghini, Gian Luigi Marseglia, Francesco Paravati, Giovanni Battista Pajno, Alberto Martelli, Elio Novembre, Gabriella Di Mauro, Francesco Macrì, Giorgio Piacentini, Maria Carmen Verga, Giovanna Tezza, Iride Dello Iacono, Lucia Leonardi, Mattia Doria, Michele Miraglia Del Giudice, Giovanna De Castro, Raffaele Falsaperla, Luciana Indinnimeo, Riccardo Lubrano, Valentina Ferraro, Renato Cutrera, Lucia Diaferio, Vito Leonardo Miniello, Giampaolo Ricci, Melissa Borrelli, Gabriella Pozzobon, Agostino Nocerino, Germana Nardini, Francesco Di Mauro, Fabio Decimo, Anna Maria Zicari, Diego Peroni, Mariangela Tosca, Maria Di Cicco, Fabio Midulla, Luigi Masini, Amelia Licari, Carlo Alfaro, Valeria Caldarelli, Caterina Di Mauro, Elena Galli, Carlo Capristo, Cristina Piersantelli, Sergio Renzo Morandini, Massimo Landi, Giovanni Cerimoniale, Valter Spanevello, Daniele Giovanni Ghiglioni, Ahmad Kantar, Dora Di Mauro, Cristina Di Mauro, Giovanni Corsello, Attilio Varricchio, Duse, M., Santamaria, F., Verga, M. C., Bergamini, M., Simeone, G., Leonardi, L., Tezza, G., Bianchi, A., Capuano, A., Cardinale, F., Cerimoniale, G., Landi, M., Malventano, M., Tosca, M., Varricchio, A., Zicari, A. M., Alfaro, C., Barberi, S., Becherucci, P., Bernardini, R., Biasci, P., Caffarelli, C., Caldarelli, V., Capristo, C., Castronuovo, S., Chiappini, E., Cutrera, R., De Castro, G., De Franciscis, L., Decimo, F., Iacono, I. D., Diaferio, L., Di Cicco, M. E., Di Mauro, C., Di Mauro, D., Di Mauro, F., Di Mauro, G., Doria, M., Falsaperla, R., Ferraro, V., Fanos, V., Galli, E., Ghiglioni, D. G., Indinnimeo, L., Kantar, A., Lamborghini, A., Licari, A., Lubrano, R., Luciani, S., Macri, F., Marseglia, G., Martelli, A. G., Masini, L., Midulla, F., Minasi, D., Miniello, V. L., del Giudice, M. M., Morandini, S. R., Nardini, G., Nocerino, A., Novembre, E., Pajno, G. B., Paravati, F., Piacentini, G., Piersantelli, C., Pozzobon, G., Ricci, G., Spanevello, V., Turra, R., Zanconato, S., Borrelli, M., Villani, A., Corsello, G., Peroni, D., Duse, Marzia, Santamaria, Francesca, Verga, Maria Carmen, Bergamini, Marcello, Simeone, Giovanni, Leonardi, Lucia, Tezza, Giovanna, Bianchi, Annamaria, Capuano, Annalisa, Cardinale, Fabio, Cerimoniale, Giovanni, Landi, Massimo, Malventano, Monica, Tosca, Mariangela, Varricchio, Attilio, Zicari, Anna Maria, Alfaro, Carlo, Barberi, Salvatore, Becherucci, Paolo, Bernardini, Roberto, Biasci, Paolo, Caffarelli, Carlo, Caldarelli, Valeria, Capristo, Carlo, Castronuovo, Serenella, Chiappini, Elena, Cutrera, Renato, De Castro, Giovanna, De Franciscis, Luca, Decimo, Fabio, Iacono, Iride Dello, Diaferio, Lucia, Di Cicco, Maria Elisa, Di Mauro, Caterina, Di Mauro, Cristina, Di Mauro, Dora, Di Mauro, Francesco, Di Mauro, Gabriella, Doria, Mattia, Falsaperla, Raffaele, Ferraro, Valentina, Fanos, Vassilio, Galli, Elena, Ghiglioni, Daniele Giovanni, Indinnimeo, Luciana, Kantar, Ahmad, Lamborghini, Adima, Licari, Amelia, Lubrano, Riccardo, Luciani, Stefano, Macrì, Francesco, Marseglia, Gianluigi, Martelli, Alberto Giuseppe, Masini, Luigi, Midulla, Fabio, Minasi, Domenico, Miniello, Vito Leonardo, Del Giudice, Michele Miraglia, Morandini, Sergio Renzo, Nardini, Germana, Nocerino, Agostino, Novembre, Elio, Pajno, Giovanni Battista, Paravati, Francesco, Piacentini, Giorgio, Piersantelli, Cristina, Pozzobon, Gabriella, Ricci, Giampaolo, Spanevello, Valter, Turra, Renato, Zanconato, Stefania, Borrelli, Melissa, Villani, Alberto, Corsello, Giovanni, Di Mauro, Giuseppe, Peroni, Diego, and Marzia Duse, Francesca Santamaria, Maria Carmen Verga, Marcello Bergamini, Giovanni Simeone, Lucia Leonardi, Giovanna Tezza, Annamaria Bianchi, Annalisa Capuano, Fabio Cardinale, Giovanni Cerimoniale, Massimo Landi, Monica Malventano, Mariangela Tosca, Attilio Varricchio, Anna Maria Zicari, Carlo Alfaro, Salvatore Barberi, Paolo Becherucci, Roberto Bernardini, Paolo Biasci, Carlo Caffarelli, Valeria Caldarelli, Carlo Capristo, Serenella Castronuovo, Elena Chiappini, Renato Cutrera, Giovanna De Castro, Luca De Franciscis, Fabio Decimo, Iride Dello Iacono, Lucia Diaferio, Maria Elisa Di Cicco, Caterina Di Mauro, Cristina Di Mauro, Dora Di Mauro, Francesco Di Mauro, Gabriella Di Mauro, Mattia Doria, Raffaele Falsaperla, Valentina Ferraro, Vassilios Fanos, Elena Galli, Daniele Giovanni Ghiglioni, Luciana Indinnimeo, Ahmad Kantar, Adima Lamborghini, Amelia Licari, Riccardo Lubrano, Stefano Luciani, Francesco Macrì, Gianluigi Marseglia, Alberto Giuseppe Martelli, Luigi Masini, Fabio Midulla, Domenico Minasi, Vito Leonardo Miniello, Michele Miraglia Del Giudice, Sergio Renzo Morandini, Germana Nardini, Agostino Nocerino, Elio Novembre, Giovanni Battista Pajno, Francesco Paravati, Giorgio Piacentini, Cristina Piersantelli, Gabriella Pozzobon, Giampaolo Ricci, Valter Spanevello, Renato Turra , Stefania Zanconato, Melissa Borrelli, Alberto Villani, Giovanni Corsello, Giuseppe Di Mauro, Diego Peroni
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Male ,Delphi Technique ,Rhinosinusitis ,Respiratory Tract Diseases ,Delphi method ,Rhinosinusiti ,Laryngitis ,Adrenal Cortex Hormone ,Pediatrics ,0302 clinical medicine ,Adrenal Cortex Hormones ,Multidisciplinary approach ,Inhaled corticosteroid ,030212 general & internal medicine ,Child ,Respiratory Tract Disease ,Rhiniti ,Societies, Medical ,Rhinitis ,education.field_of_study ,Inhaled corticosteroids ,Wheezing ,General Medicine ,Settore MED/38 ,Systematic review ,Italy ,Laryngotracheitis ,Child, Preschool ,Laryngotracheiti ,Female ,medicine.symptom ,Human ,medicine.medical_specialty ,Consensus ,Adolescent ,Population ,Consensu ,RJ1-570 ,03 medical and health sciences ,Intervention (counseling) ,Administration, Inhalation ,medicine ,Laryngospasm ,Humans ,Adenoid hypertrophy ,education ,Intensive care medicine ,Asthma ,business.industry ,Research ,Infant ,medicine.disease ,030228 respiratory system ,business - Abstract
Background In 2019, a multidisciplinary panel of experts from eight Italian scientific paediatric societies developed a consensus document for the use of inhaled corticosteroids in the management and prevention of the most common paediatric airways disorders. The aim is to provide healthcare providers with a multidisciplinary document including indications useful in the clinical practice. The consensus document was intended to be addressed to paediatricians who work in the Paediatric Divisions, the Primary Care Services and the Emergency Departments, as well as to Residents or PhD students, paediatric nurses and specialists or consultants in paediatric pulmonology, allergy, infectious diseases, and ear, nose, and throat medicine. Methods Clinical questions identifying Population, Intervention(s), Comparison and Outcome(s) were addressed by methodologists and a general agreement on the topics and the strength of the recommendations (according to the GRADE system) was obtained following the Delphi method. The literature selection included secondary sources such as evidence-based guidelines and systematic reviews and was integrated with primary studies subsequently published. Results The expert panel provided a number of recommendations on the use of inhaled corticosteroids in preschool wheezing, bronchial asthma, allergic and non-allergic rhinitis, acute and chronic rhinosinusitis, adenoid hypertrophy, laryngitis and laryngospasm. Conclusions We provided a multidisciplinary update on the current recommendations for the management and prevention of the most common paediatric airways disorders requiring inhaled corticosteroids, in order to share useful indications, identify gaps in knowledge and drive future research.
- Published
- 2021
11. Component resolved diagnosis and risk assessment in food allergy
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Alberto, Martelli, Mauro, Calvani, Thomas, Foiadelli, Mariangela, Tosca, Giuseppe, Pingitore, Amelia, Licari, Alessia, Marseglia, Giorgio, Ciprandi, and Carlo, Caffarelli
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Humans ,Allergens ,Immunoglobulin E ,Child ,Risk Assessment ,Food Hypersensitivity ,Skin Tests - Abstract
Allergy testing should only be performed in the context of the clinical history as history provides the cornerstone of diagnosis. In food allergy, some allergy tests often give rise to false positive results and thus can lead to unnecessary avoidance or delay on foods introduction. The use of Component Resolved Diagnosis in combination with conventional sensitization testing improves analytical and diagnostic performance and can lead to the reduction of diagnostic oral food challenges. Component Resolved Diagnosis can be helpful in identifying some risks for the allergic child. Molecular diagnosis can help also in predicting the development of the allergy march, in severe reactions (lipid transfer protein, seed storage proteins, etc.) in food allergy and for potential clinical cross-reactivity.
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- 2021
12. Use of remdesivir in children with COVID-19 infection: a quick narrative review
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Andrea, La Tessa, Marco Antonio, Motisi, Gian Luigi, Marseglia, Fabio, Cardinale, Amelia, Licari, Sara, Manti, Mariangela, Tosca, Michele Miraglia, Del Giudice, Maria, De Filippo, Luisa, Galli, and Elena, Chiappini
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Adult ,Alanine ,SARS-CoV-2 ,Infant, Newborn ,Humans ,Child ,Adenosine Monophosphate ,COVID-19 Drug Treatment - Abstract
SARS-CoV-2 infection has a severe course in a small percentage of children. Remdesivir has shown promising results in reducing hospitalisation time in adults, but data on mortality rate are conflicting and few studies are available on its use use in antivirals in children. We performed a quick narrative review of the available literature data regarding the usage of remdesivir in children and neonates. In children, remdesivir showed good safety profile, however bradicardia events have been reported in children. Remdesivir is currently recommended by several guidelines in some subgroups of children with severe COVID-19, and should also be considered in critically ill patients, always in the context of the overall clinical picture and drug availability.
- Published
- 2021
13. The gender effect in children and adolescents with asthma: practical outcomes from the 'ControL'Asma' study
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I. Schiavetti, Giorgio Ciprandi, G.L. Marseglia, and Mariangela Tosca
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business.industry ,medicine.disease ,Asthma ,adolescents ,asthma control ,children ,gender ,Gender effect ,Asthma control ,Immunology and Allergy ,Medicine ,business ,Control (linguistics) ,Clinical psychology - Published
- 2021
14. Bronchial obstruction perception and uncontrolled asthma in clinical practice
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Irene Schiavetti, Mariangela Tosca, and G. Ciprandi
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,media_common.quotation_subject ,Clinical practice ,Adolescents ,Perception ,Asthma control ,Medicine ,Humans ,Bronchial obstruction ,Intensive care medicine ,Children ,Asthma ,media_common ,business.industry ,Bronchial Diseases ,medicine.disease ,Uncontrolled asthma ,Clinical Practice ,Airway Obstruction ,business - Published
- 2021
15. Inhaled corticosteroids use in childhood respiratory diseases: an italian survey on pediatricians' prescription habits
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Alberto Villani, Riccardo Lubrano, Luciana Indinnimeo, Mattia Doria, Gian Luigi Marseglia, Marzia Duse, Paolo Becherucci, Giovanni Cerimoniale, Giuseppe Di Mauro, Mariangela Tosca, Paolo Biasci, Maria Di Cicco, Gabriella Pozzobon, Giorgio Piacentini, Maria Carmen Verga, and Diego Peroni
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Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Attitude of Health Personnel ,medicine.medical_treatment ,Respiratory Tract Diseases ,Inhaled corticosteroids ,Laryngitis ,Computer-assisted web interviewing ,Drug Prescriptions ,Habits ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,children ,Adrenal Cortex Hormones ,preschool wheezing ,Surveys and Questionnaires ,030225 pediatrics ,Administration, Inhalation ,medicine ,Humans ,Pediatricians ,Medical prescription ,Child ,laryngitis ,Retrospective Studies ,Asthma ,Asthma exacerbations ,allergic rhinitis ,business.industry ,Research ,lcsh:RJ1-570 ,lcsh:Pediatrics ,Middle Aged ,asthma ,medicine.disease ,inhaled corticosteroids ,Settore MED/38 ,Checklist ,Cross-Sectional Studies ,Italy ,Female ,Antihistamine ,business - Abstract
Background A national consensus document on inhaled corticosteroids (ICS) use in childhood, produced by the main Italian pediatric scientific societies, has been recently released. The aim of this study was to gather information on the current pediatricians’ ICS prescription habits in Italy for the management of the most common pediatric respiratory diseases, namely allergic rhinitis (AR), asthma, preschool wheezing and laryngitis. Methods From the 1st October 2018 to the 31st January 2019 a link to an online questionnaire was sent monthly through a newsletter to the members of the Italian Society of Pediatrics. The questionnaire included 18 items on ICS use in the most common pediatric respiratory diseases. Data collection and reporting was based on STROBE Statement Checklist for cross-sectional studies. Results One thousand-two questionnaires were returned from primary care pediatricians (39.1%), hospital pediatricians (38.7%), private practicers (16.4%), university pediatricians (3.1%) and Pediatrics residents (2.7%). We found a good adherence to the international guidelines on AR, with prevalent use of oral antihistamine (60.6%) in the secretive phenotype and nasal ICS in the obstructive phenotype (64.8%). In asthma exacerbations ICS are not used in 53.4% of cases, but they are used at high dose in 27.9% and at low dose in 18.7% of cases. In intermittent asthma, ICS are not chosen as a daily controller therapy in 54.1% of cases, while they are chosen as a low dose daily therapy in 44.5% of cases (high dose in 1.4%). In children with persistent asthma, ICS are chosen as a daily low dose therapy in 67.4% of cases and as a daily high dose therapy in 31%. In the management of preschool wheezing, when a long-term treatment is needed, ICS are chosen both alone and in association with antileukotrienes in 71.4% of cases. Children affected by recurrent asthma exacerbations and wheezing are closely followed up, in particular by their primary care pediatricians. The preference for certain molecules in the treatment of different respiratory diseases also emerged. Conclusions Pediatricians’ ICS prescription habits in Italy should be improved, especially in the management of asthma. Future surveys on a more numerous sample will be useful to analyze differences in prescription habits on the basis of pediatricians’ work settings and geographical distribution.
- Published
- 2021
16. United airway disease
- Author
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Angela, Klain, Cristiana, Indolfi, Giulio, Dinardo, Amelia, Licari, Fabio, Cardinale, Carlo, Caffarelli, Sara, Manti, Giampaolo, Ricci, Giuseppe, Pingitore, Mariangela, Tosca, Fabio, Decimo, Michele, Miraglia Del Giudice, Klain, A., Indolfi, C., Dinardo, G., Licari, A., Cardinale, F., Caffarelli, C., Manti, S., Ricci, G., Pingitore, G., Tosca, M., Decimo, F., and Miraglia Del Giudice, M.
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Humans ,Respiration Disorders ,Lung ,Rhinitis, Allergic ,Asthma - Abstract
Nose and lungs are considered as anatomic and functional unit, as they share morphological, pathophysiological and immunological basis. Allergic rhinitis and asthma often coexist in the same individual, and the treatment of one also improves the symptoms of the other (one airway, one disease). The aim of this review is to discuss the interaction between upper and lower airways, based on recent scientific evidence and, critically, analyze the important implications the new findings have for the future therapy and prevention of these common diseases.
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- 2021
17. Allergy and covid-19
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Maria, De Filippo, Martina, Votto, Ilaria, Brambilla, Riccardo, Castagnoli, Lorenza, Montagna, Carlo, Caffarelli, Fabio, Cardinale, Michele, Miraglia Del Giudice, Mariangela, Tosca, Silvia, Caimmi, Amelia, Licari, Gian Luigi, Marseglia, De Filippo, M., Votto, M., Brambilla, I., Castagnoli, R., Montagna, L., Caffarelli, C., Cardinale, F., Miraglia Del Giudice, M., Tosca, M., Caimmi, S., Licari, A., and Marseglia, G. L.
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Adult ,Disease Outbreak ,Adolescent ,Allergy ,Pandemic ,SARS-CoV-2 ,Allergic asthma ,COVID-19 ,Eosinophil ,Disease Outbreaks ,Phenotype ,Hypersensitivity ,Humans ,Pandemics ,Children ,Human - Abstract
The first cases of as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported in Wuhan, China in December 2019. The World Health Organization declared the global pandemic in March 2020. Coronavirus disease 2019 (COVID-19) showed high rates of mortality in the adult popula-tion, whereas a mild course was observed in childhood. Allergic diseases, characterized by a type-2 polariza-tion of the immune system, were considered one of the major risk factor of severe COVID-19. Large amounts of clinical data and expert opinions have been collected since the pandemic outbreak. This review summarizes the latest insights on COVID-19 and allergy. (www.actabiomedica.it).
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- 2021
18. The impact of age on serum allergen-specific IgE to inhaled molecular components
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Roberta Olcese, Michela Silvestri, Mariangela Tosca, G. A. Rossi, Giorgio Ciprandi, and Angela Pistorio
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Adult ,Male ,Pulmonary and Respiratory Medicine ,Aging ,Allergy ,Adolescent ,Immunology ,Immunoglobulin E ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Humans ,Immunology and Allergy ,Medicine ,030212 general & internal medicine ,Young adult ,Child ,Allergen specific IgE ,Retrospective Studies ,biology ,business.industry ,Age Factors ,Rhinitis, Allergic, Seasonal ,General Medicine ,Allergens ,Middle Aged ,medicine.disease ,030228 respiratory system ,Quartile ,Ageing ,biology.protein ,Female ,Analysis of variance ,business - Abstract
Respiratory allergy is characterised by an IgE-mediated reaction. The immune system functions, including IgE production, progressively decline over time, such as growing up and ageing. Molecular-based allergy diagnostic defines sensitisation profile. This study aimed to evaluate the impact of age on serum allergen-specific IgE to molecular component levels in a large sample of subjects.Serum IgE to: Phl p1, Bet v1, Ole e1, Cup a1, Par j2, Can f1, Der p2, and Fel d1 were assessed by ISAC method. Sera from 2788 patients, 1230 males (44.1%) and 1558 females (55.9%), median age 23 years (1st and 3rd quartiles: 9.7-49.7 years; age range: 1 month-103 years) were analysed.The number of positive tests (i.e. sensitisation) tended to increase between birth and school-age till young adulthood and then decreased (p0.0001) with the exception of Fel d 1 (p=0.14). A similar age-dependent trend was observed considering the levels of each allergen components: the levels of each allergen component, with the exception of Fel d 1, tended to increase till early adulthood and then to decrease reaching the lowest levels in the elderly.Allergen-specific IgE production to inhaled molecular components trend to reduce with ageing, but with differences between allergens. This phenomenon should be adequately evaluated managing allergic patients.
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- 2017
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19. Hexavalent vaccines in preterm infants: an update by Italian Society of Pediatric Allergy and Immunology jointly with the Italian Society of Neonatology
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Fabio Mosca, Mauro Calvani, Domenico Minasi, Chiara Petrolini, Carlo Caffarelli, Carlo Pietrasanta, Elena Chiappini, Arabella Martelli, Lorenza Pugni, Marzia Duse, G B Pajno, Mariangela Tosca, Sara Manti, Gian Luigi Marseglia, Fabio Cardinale, M. Miraglia Del Giudice, Amelia Licari, Chiappini, E., Petrolini, C., Caffarelli, C., Calvani, M., Cardinale, F., Duse, M., Licari, A., Manti, S., Martelli, A., Minasi, D., Miraglia Del Giudice, M., Pajno, G. B., Pietrasanta, C., Pugni, L., Tosca, M. A., Mosca, F., and Marseglia, G. L.
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Pediatrics ,medicine.medical_specialty ,Vaccination schedule ,Hexavalent vaccines ,Preterm infants ,Vaccines ,Review ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Humans ,Medicine ,Age Factor ,Hexavalent vaccine ,Vaccines, Combined ,030212 general & internal medicine ,Neonatology ,Adverse effect ,Immunization Schedule ,Age Factors ,Infant ,Infant, Newborn ,Infant, Premature ,Italy ,Practice Guidelines as Topic ,business.industry ,Tetanus ,Diphtheria ,lcsh:RJ1-570 ,lcsh:Pediatrics ,medicine.disease ,Vaccination ,Immunization ,Preterm infant ,Vaccine-preventable diseases ,business ,Vaccine ,Human - Abstract
Hexavalent vaccines, protecting against six diseases (diphtheria, tetanus, pertussis [DTaP], poliovirus, hepatitis B virus [HBV], and Haemophilus influenzae type b [Hib], are routinely the standard of care in Europe. The use of combined vaccines allows the reduction of number of injections and side effects, the reduction of costs, and the increase in adherence of the family to the vaccination schedule both in terms of the number of doses and timing. The safety profile, efficacy and effectiveness of hexavalent vaccines have been extensively documented in infants and children born at term, and data are accumulating in preterm infants. Hexavalent vaccines are particularly important for preterm infants, who are at increased risk for severe forms of vaccine preventable diseases. However, immunization delay has been commonly reported in this age group. All the three hexavalent vaccines currently marketed in Italy can be used in preterm infants, and recent data confirm that hexavalent vaccines have a similar or lower incidence of adverse events in preterm compared to full-term infants; this is likely due to a weaker immune system response and reduced ability to induce an inflammatory response in preterm infants. Apnoea episodes are the adverse events that can occur in the most severe preterm infants and / or with history of respiratory distress. The risk of apnoea after vaccination seems to be related to a lower gestational age and a lower birth weight, supporting the hypothesis that it represents an unspecific response of the preterm infant to different procedures. High seroprotection rates have been reported in preterm infants vaccinated with hexavalent vaccine. However, a lower gestational age seems to be associated with lower antibody titres against some vaccine antigens (e.g. HBV, Hib, poliovirus serotype 1, and pertussis), regardless of the type of hexavalent vaccine used. Waiting for large effectiveness studies, hexavalent vaccines should be administered in preterm infants according to the same schedule recommended for infants born at term, considering their chronological age and providing an adequate monitoring for cardio-respiratory events in the 48–72 h after vaccination, especially for infants at risk of recurrence of apnoea.
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- 2019
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20. Can an otorhinolaryngological visit induce the suspect of allergic rhinitis in children?
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Franco Ameli, Mariangela Tosca, Amelia Licari, Giorgio Ciprandi, and Fabio Gallo
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Male ,medicine.medical_specialty ,Passive smoking ,Palatine Tonsil ,medicine.disease_cause ,Adenoid ,Atopy ,Otolaryngology ,medicine ,Immunology and Allergy ,Humans ,Child ,Asthma ,Skin Tests ,Sleep disorder ,business.industry ,Otitis Media with Effusion ,Endoscopy ,medicine.disease ,Comorbidity ,Dermatology ,Rhinitis, Allergic ,medicine.anatomical_structure ,Otitis ,Tonsil ,Child, Preschool ,Adenoids ,Female ,medicine.symptom ,business - Abstract
Summary Allergic rhinitis (AR) is very frequent in childhood. AR is commonly associated with some co-morbidities and typical clinical features. This study aimed to test the hypothesis whether an otorhinolaryngological (ORL) visit could induce the suspect of AR. Globally, 1,002 children (550 males, mean age 5.77 years) were consecutively visited at an ORL clinic. Clinical visit, nasal endoscopy, and skin prick test were performed in all patients. In particular, history investigated atopic familiarity, birth, feeding type, passive smoking, comorbidities, including asthma, respiratory infections, otitis media, respiratory sleep disorder. Endoscopy assessed the tonsil and adenoid volume, turbinate contacts, mucosal color, and nasal discharge. Univariate and multivariate analysis were performed. The study showed that 547 (54.6%) children had AR. Some parameters were predicting factor for suspecting AR: middle turbinate contact (OR = 9.27), familial atopy (OR = 6.24), pale nasal mucosa (OR = 4.95), large adenoid volume (OR = 3.02 for score 4), and asthma co-morbidity (OR = 2.95). In conclusion this real-life study showed that during an ORL visit it is possible to suspect AR in children with turbinate hypertrophy, familial atopy, nasal pale mucosa, adenoid enlargement, and asthma comorbidity.
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- 2019
21. When asthma and rhinitis coexist, could rhinitis reduce asthma control in children?
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Massimiliano Marazzato, Luciana Indinnimeo, Mariangela Tosca, Laura Schiavi, Valentina De Vittori, Marzia Duse, Giovanna De Castro, Anna Pacilio, Anna Maria Zicari, and Giulia Brindisi
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Pulmonary and Respiratory Medicine ,Spirometry ,medicine.medical_specialty ,Disease ,01 natural sciences ,03 medical and health sciences ,0302 clinical medicine ,immune system diseases ,Internal medicine ,Asthma control ,medicine ,Mite ,Immunology and Allergy ,Humans ,0101 mathematics ,asthma ,act ,children ,allergy ,Asthma ,Rhinitis ,medicine.diagnostic_test ,biology ,business.industry ,010102 general mathematics ,General Medicine ,medicine.disease ,biology.organism_classification ,respiratory tract diseases ,030228 respiratory system ,Exhaled nitric oxide ,Cohort ,business ,Asthma Control Test - Abstract
Background Bronchial asthma and rhinitis are among the most common diseases in children and frequently coexist in the patient. The primary aim of anti-asthmatic therapy is disease control. Several questionnaires can be used in pediatrics to assess asthma control and the Children Asthma Control Test (C-ACT) is one of the most used. Objective To evaluate the percentage of asthma control in our cohort of patients with asthma and correlate C-ACT with bronchial and nasal function tests. Methods We enrolled all children ages between 5 and 11 years with persistent bronchial asthma, sensitized to dust mite, and who presented to our center during an 8-month period. All the children had skin-prick tests, spirometry, measurement of fractional exhaled nitric oxide levels, active anterior rhinomanometry, measurement of nasal nitric oxide level, and C-ACT. Results Sixty patients were enrolled; 80% of these children had rhinitis. According to C-ACT, 31% of our patients had uncontrolled asthma. Nasal flow values were significantly lower in patients with uncontrolled asthma, who also had higher nasal inflammation. Conclusion The disease is not controlled in a significant percentage of children with asthma. In patients with uncontrolled asthma, worse nasal flow was detected. These results supported the relationship between upper and lower airways, and highlighted the importance of performing nasal function tests in all patients with asthma, which could be useful to determine whether better control of asthma symptoms can be reached through an appropriate treatment of rhinitis.
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- 2019
22. Anaphylactic Shock During Pediatric Anesthesia: An Unexpected Reaction to Sevoflurane
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Francesca Antonini, Brunella Gily, Etrusca Brogi, Genny Del Zotto, Claudia Barbieri, Alessandro Simonini, and Mariangela Tosca
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Allergy ,medicine.drug_class ,Positive reaction ,Antibiotics ,Sevoflurane ,03 medical and health sciences ,0302 clinical medicine ,030202 anesthesiology ,medicine ,anaphylaxis ,perioperative complications ,business.industry ,lcsh:RJ1-570 ,Anaphylactic reactions ,anaphylactic shock ,lcsh:Pediatrics ,medicine.disease ,allergy ,030228 respiratory system ,Anesthesia ,Pediatrics, Perinatology and Child Health ,Anaphylactic shock ,Pediatric anesthesia ,business ,Anaphylaxis ,medicine.drug ,pediatric anesthesia - Abstract
During general anesthesia, while muscle relaxants, latex and antibiotics are normally considered as very common causes of anaphylactic reactions, there are no documented cases of anaphylaxis due to inhalational agents. We report the case of a 6-year-old child scheduled for adenotonsillectomy who had an anaphylactic shock reaction due to Sevoflurane. Several allergic tests were performed to detect the trigger. Drugs used during operation were tested on both patient and three matched controls. While controls were negative, the patient displayed a positive reaction to Sevoflurane. To our knowledge, this is the first published report describing an allergic reaction caused by a volatile anesthetic.
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- 2018
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23. Diagnostic relevance of IgE sensitization profiles to eight recombinant Phleum pratense molecules
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Giuseppe Pingitore, Nunzia Maiello, Francesco Macrì, Mario Plebani, Pasquale Comberiati, Salvatore Tripodi, Francesca Cipriani, A Di Rienzo Businco, Valentina Panetta, Viviana Moschese, Maria Francesca Patria, Carla Mastrorilli, Diego Faggian, Tullio Frediani, P M Matricardi, Simone Frediani, M. Miraglia Del Giudice, Carlo Caffarelli, Mauro Calvani, Arianna Dondi, Diego Peroni, Umberto Pelosi, F. Paravati, C Lambiase, Mariangela Tosca, Maria Carmen Verga, Sandra Lucarelli, Loredana Chini, Serena Perna, I Dello Iacono, Roberto Bernardini, C. Povesi Dascola, Annamaria Bianchi, Riccardo Asero, Elena Varin, Ifigenia Sfika, Giampaolo Ricci, Cipriani, F., Mastrorilli, C., Tripodi, S., Ricci, G., Perna, S., Panetta, V., Asero, R., Dondi, A., Bianchi, A., Maiello, N., Miraglia del Giudice, M., Frediani, T., Macrì, F., Lucarelli, S., Dello Iacono, I., Patria, M.F., Varin, E., Peroni, D., Chini, L., Moschese, V., Bernardini, R., Pingitore, G., Pelosi, U., Tosca, M., Paravati, F., Sfika, I., Businco, A. Di Rienzo, Povesi Dascola, C., Comberiati, P., Frediani, S., Lambiase, C., Verga, M.C., Faggian, D., Plebani, M., Calvani, M., Caffarelli, C., Matricardi, P.M., Macrã¬, F., Patria, M. F., Verga, M. C., and Matricardi, P. M.
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Male ,Allergy ,grass pollen ,Immunoglobulin E ,Airborne allergen ,component-resolved diagnostics ,Atopy ,0302 clinical medicine ,allergy ,children ,IgE sensitization profiles ,Immunology and Allergy ,Immunology ,030212 general & internal medicine ,Child ,Sensitization ,Rhinitis ,biology ,Settore MED/38 ,Recombinant Proteins ,Phleum pratense ,medicine.anatomical_structure ,Italy ,Child, Preschool ,Female ,Adolescent ,IgE sensitization profile ,Phleum ,03 medical and health sciences ,Allergic ,Oral allergy syndrome ,medicine ,Humans ,Preschool ,Asthma ,Settore MED/38 - Pediatria Generale e Specialistica ,Seasonal ,business.industry ,Component-resolved diagnostic ,Rhinitis, Allergic, Seasonal ,Allergens ,medicine.disease ,biology.organism_classification ,Cross-Sectional Studies ,030228 respiratory system ,biology.protein ,business ,Biomarkers - Abstract
Background Grass pollen–related seasonal allergic rhinoconjunctivitis (SARg) is clinically heterogeneous in severity, comorbidities and response to treatment. The component-resolved diagnostics disclosed also a high heterogeneity at molecular level. Our study aimed at analyzing the characteristics of the IgE sensitization to Phleum pratense molecules and investigating the diagnostic relevance of such molecules in childhood. Methods We examined 1120 children (age 4–18y) with SARg. Standardized questionnaires on atopy were acquired through informatics platform (AllergyCARD™). Skin prick tests were performed with pollen extracts. Serum IgE to airborne allergens and eight Phleum pratense molecules (rPhl p 1, rPhl p 2, rPhl p 4, rPhl p 5b, rPhl p 6, rPhl p 7, rPhl p 11, rPhl p 12) were tested by ImmunoCAP FEIA. Results The analysis of IgE responses against eight Phleum pratense molecules showed 87profiles. According to the number of molecules recognized by IgE, the more complex profiles were characterized by higher serum total IgE, higher grass-specific serum IgE and higher number and degree of sensitization to pollens. The most frequent IgE sensitization profile was the monomolecular Phl p 1. Sensitization to Phl p 7 was a reliable biomarker of asthma, whereas Phl p 12 of oral allergy syndrome. Sensitization to Phl p 7 was associated with a higher severity of SAR, and complex profiles were associated with longer disease duration. Conclusions In a large pediatric population, the complexity of IgE sensitization profiles against Phleum pratense molecules is related to high atopic features although useless for predicting the clinical severity. The detection of serum IgE to Phl p 1, Phl p 7 and Phl p 12 can be used as clinical biomarkers of SARg and comorbidities. Further studies in different areas are required to test the impact of different IgE molecular profiles on AIT response. This article is protected by copyright. All rights reserved.
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- 2018
24. 72nd Congress of the Italian Society of Pediatrics
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Marco Braghero, Annamaria Staiano, Eleonora Biasin, Patrizia Matarazzo, Silvia Einaudi, Rosaria Manicone, Francesco Felicetti, Enrico Brignardello, Franca Fagioli, Elisabetta Bignamini, Elena Nave, F. Callea, C. Concato, E. Fiscarelli, S. Garrone, M.Rossi de Gasperis, Patrizia Calzi, Grazia Marinelli, Roberto Besana, Carlo Caffarelli, Antonio Di Peri, Irene Lapetina, Patrizia Cincinnati, Rosalia Maria Da Riol, Mario De Curtis, Lucia Dito, Chiara Protano, Susanna Esposito, Dante Ferrara, Rossella Galiano, Pasquale Novellino, Eric Heath Kossoff, Andrzej Krzysztofiak, Elena Bozzola, Laura Lancella, Alessandra Marchesi, Alberto Villani, Paola Lago, Elisabetta Garetti, Anna Pirelli, Paola Marchisio, Maria Santagati, Stefania Stefani, Nicola Principi, Valeria d’Apolito, Luigi Memo, Angelo Selicorni, Vito Leonardo Miniello, Lucia Diaferio, Antonella Palmieri, Luciana Parola, Ettore Piro, Claudio Romano, Maria Ausilia Catena, Sabrina Cardile, Oliviero Sacco, Donata Girosi, Roberta Olcese, Mariangela Tosca, Giovanni Arturo Rossi, Sergio Salerno, Maria Chiara Terranova, Francesca Santamaria, Giorgia Mancano, Silvia Maitz, Virginia A. Stallings, Chiara Berlolaso, Carolyn McAnlis, Joan I. Schall, Pasquale Striano, Rita Tanas, Giulia De Iaco, Maria Marsella, Guido Caggese, Paolo Toma, Piero Valentini, Danilo Buonsenso, David Pata, Manuela Ceccarelli, Elvira Verduci, Marta Brambilla, Benedetta Mariani, Carlotta Lassandro, Alice Re Dionigi, Sara Vizzuso, Giuseppe Banderali, Gianvito Panzarino, Claudia Di Paolantonio, Alberto Verrotti, Laura Cursi, Annalisa Grandin, Raffaele Virdis, Patrizia Carletti, Giovanna Weber, Silvana Caiulo, and Maria Cristina Vigone
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03 medical and health sciences ,Pediatrics ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,Maternal and child health ,030225 pediatrics ,Family medicine ,medicine ,030212 general & internal medicine ,business - Published
- 2017
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25. Hazelnut anaphylaxis: The usefulness of molecular-based allergy diagnostics
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Michela Silvestri, Angela Pistorio, Giorgio Ciprandi, Mariangela Tosca, and G. A. Rossi
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medicine.medical_specialty ,Allergy ,Food allergy ,business.industry ,medicine ,Immunology and Allergy ,medicine.disease ,business ,Dermatology ,Anaphylaxis - Published
- 2015
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26. Type 1 diabetes mellitus and asthma: A follow-up study
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G. Romanisio, Giuseppe d'Annunzio, Angela Pistorio, Renata Lorini, Michela Silvestri, Giorgio Ciprandi, Mariangela Tosca, and Giovanni A. Rossi
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Adult ,Male ,Pulmonary and Respiratory Medicine ,Pediatrics ,medicine.medical_specialty ,Immunology ,MEDLINE ,Body Mass Index ,Young Adult ,Diabetes mellitus ,Humans ,Immunology and Allergy ,Medicine ,Young adult ,Skin Tests ,Asthma ,Type 1 diabetes ,business.industry ,Incidence ,Incidence (epidemiology) ,Follow up studies ,General Medicine ,medicine.disease ,Respiratory Function Tests ,Diabetes Mellitus, Type 1 ,Female ,business ,Body mass index ,Follow-Up Studies - Published
- 2015
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27. Allergen-specific IgE to food molecular components and age: From early childhood to adulthood
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Mariangela Tosca, Roberta Olcese, Giovanni A. Rossi, Angela Pistorio, O. Sacco, Giorgio Ciprandi, and Michela Silvestri
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Pulmonary and Respiratory Medicine ,Adult ,Male ,Allergy ,Aging ,Adolescent ,Immunology ,medicine.disease_cause ,Immunoglobulin E ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Allergen ,Immune system ,Immunology and Allergy ,Medicine ,Humans ,Early childhood ,Young adult ,Pathology, Molecular ,Child ,biology ,business.industry ,Age Factors ,General Medicine ,Allergens ,medicine.disease ,030228 respiratory system ,Quartile ,Ageing ,Food ,biology.protein ,Female ,Immunization ,business ,Food Hypersensitivity ,030215 immunology - Abstract
Background Respiratory allergy is characterised by an IgE-mediated reaction. The immune system functions, including IgE production, progressively decline over time with growing up and ageing. Molecular-based allergy diagnostic defines sensitisation profile. This study aimed to evaluate the impact of age on serum allergen-specific IgE to molecular component levels in a large sample of subjects. Methods Serum IgE to: rCor a11, rPru p3, nJug r3, rAra h8, rGly m4, rCor a8, nPen m1, nAct d8, Bos d 8, and nGal d2 were assessed by ISAC method. Sera from 2795 patients, 1234 males (44.1%) and 1561 females (55.9%), median age 23 years (1st and 3rd quartiles: 9.7–43.7 years; age range: 1 month-103 years) were analysed. Results The number of positive tests (i.e. sensitisation) tended to increase between birth and school-age until young adulthood and then decreased. A similar age-dependent trend was observed considering the levels of each allergen components: the levels of each allergen component tended to increase until early adulthood, but Gal d 2 and Bos d 8 (rapidly diminishing), and then to decrease over time. However, the pattern is significantly dependent on each single tested food. Conclusions Allergen-specific IgE production to food molecular components tend to reduce with ageing, but with differences between allergens. This phenomenon should be adequately evaluated managing allergic patients.
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- 2016
28. Allergen-specific immunotherapy: an update on immunological mechanisms of action
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Mariangela Tosca, Gian Luigi Marseglia, and Giorgio Ciprandi
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Pulmonary and Respiratory Medicine ,Time Factors ,T-Lymphocytes ,atopy ,lcsh:Medicine ,Immunoglobulin E ,Atopy ,Route of administration ,Immune system ,Hypersensitivity ,Respiratory Hypersensitivity ,medicine ,Humans ,Sublingual immunotherapy ,Skin Tests ,IgG4 ,Clinical Trials as Topic ,biology ,business.industry ,lcsh:R ,Specific immunotherapy ,Dendritic Cells ,Allergens ,medicine.disease ,Slit ,Allergen-specific immunotherapy ,Desensitization, Immunologic ,Immunoglobulin G ,Immunology ,biology.protein ,IgE ,Antibody ,Cardiology and Cardiovascular Medicine ,business - Abstract
Specific immunotherapy (SIT) is the only treatment able to modify the natural history of the allergic subjects. Several aspects of the immunopathological response modified by SIT have been investigated; the first parameter historically studied was the production of allergen-specific antibodies. An increase of allergen-specific IgG4 and a decrease of IgE appear after SIT. A shift from Th2-polarized immune response toward Th1-oriented pattern has been reported after SIT. More recently, a crucial role for a subpopulation of T cells has been evidenced: T regulatory cells (Treg). Allergic patients have a defect of Tregs. SIT is able of inducing a specific Treg response. Sublingual immunotherapy is an alternative route of administration for SIT. Recent evidence shows that SLIT is also able of inducing a Treg response as detected by IL- 10 production.
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- 2016
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29. The IgE repertoire in children and adolescents resolved at component level: A cross‐sectional study
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Gyada Bazurro, Giorgio Walter Canonica, R. E. Rossi, Giovanni Passalacqua, Giovanni Melioli, Alessia Agazzi, Laura Marcomini, Giovanni A. Rossi, Mariangela Tosca, Paola Minale, and Giorgio Reggiardo
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Adult ,Male ,Allergy ,Adolescent ,Immunology ,Cross Reactions ,Immunoglobulin E ,medicine.disease_cause ,Young Adult ,Allergen ,Hypersensitivity ,medicine ,Mite ,Humans ,Immunology and Allergy ,Pathology, Molecular ,Young adult ,Child ,Sensitization ,biology ,Repertoire ,Age Factors ,Infant, Newborn ,Infant ,Allergens ,Microarray Analysis ,biology.organism_classification ,medicine.disease ,Cross-Sectional Studies ,medicine.anatomical_structure ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Cohort ,biology.protein ,Female - Abstract
To cite this article: Melioli G, Marcomini L, Agazzi A, Bazurro G, Tosca M, Rossi GA, Minale P, Rossi R, Reggiardo G, Canonica GW, Passalacqua G. The IgE repertoire in children and adolescents resolved at component level: A cross-sectional study. Pediatr Allergy Immunol 2012: 23: 433–440. Abstract Background: It is well known that allergy evolves at clinical level from the birth to adulthood, and this has been clearly demonstrated also at a level of sensitization. However, little information is available on the evolution of the IgE repertoire directed to single allergenic components. In this cross-sectional, observational study, the evolution of the IgE repertoire was analysed at component level. Methods: Serum samples from 901 allergic patients, stratified in 6 groups according to age, were analysed by ImmunoCAP ISAC, a microarray chip that allows to identify the presence of specific IgE towards 103 different allergen components. Total IgE were also evaluated. Results: The behaviour of total IgE according to age strictly paralleled that of the sum of specific IgE directed to molecular components. As expected, food-related components (in particular those of milk and egg) were the most frequently recognized in the earliest ages, whereas specific IgE to plant allergens appeared invariably later. Nonetheless, IgE specific to mite components was the most represented in all age classes. Of note, specific IgE against cross-reacting allergens was virtually absent in the first years and tended to appear only after the age of 6. Conclusion: Despite this was not a study performed on a cohort of patients followed up from birth to adolescence, the molecular patterns of allergen recognition resulted modified according to age. These findings may support, at molecular level, the clinical features of the allergic march.
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- 2011
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30. Nitric oxide metabolites in allergic rhinitis: The effect of pollen allergen exposure
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Dietmar Fuchs, Giorgio Ciprandi, and Mariangela Tosca
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Adult ,Male ,Pulmonary and Respiratory Medicine ,Pollen allergen ,Visual analogue scale ,Immunology ,Inflammation ,Nitric Oxide ,medicine.disease_cause ,Nitric oxide ,Allergic inflammation ,chemistry.chemical_compound ,Pollen ,otorhinolaryngologic diseases ,medicine ,Humans ,Immunology and Allergy ,Nitrite ,Nitrites ,business.industry ,Rhinitis, Allergic, Seasonal ,Environmental Exposure ,General Medicine ,Allergens ,Antigens, Plant ,chemistry ,Female ,Immunization ,Seasons ,Nasal Obstruction ,Nitric Oxide Synthase ,medicine.symptom ,ALLERGEN EXPOSURE ,business - Abstract
Background Seasonal allergic rhinitis (SAR) is characterised by an inflammation consequent to allergen exposure. Nitric oxide may be involved in allergic inflammation. Objective This study evaluated the serum nitrite concentrations in SAR patients during and outside pollen exposure in order to estimate activity of nitric oxide synthases. Methods One hundred and two (56 females, 46 males, median age: 28.7 years) were included in this study: 56 with SAR evaluated outside the pollen season and so without allergic inflammation and symptoms, and 46 with SAR evaluated during the pollen season with symptoms. Serum concentrations of nitrite were measured and in those patients exposed to pollens, results were compared to scores of the Visual Analogue Scale for nasal obstruction perception. Results Serum nitrite concentrations were higher in SAR patients evaluated outside the pollen season (U=-6.78; p
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- 2011
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31. Body Mass Index is Related with Bronchial Function and Reversibility in Children with Allergic Rhinitis and Asthma
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Salvatore Leonardi, Gian Luigi Marseglia, Ilaria Brambilla, Giorgio Ciprandi, A. Salpietro, Mariangela Tosca, Teresa Arrigo, and M. La Rosa
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Male ,Spirometry ,medicine.medical_specialty ,Rhinitis, Allergic, Perennial ,Adolescent ,Vital Capacity ,Immunology ,Bronchi ,Overweight ,Body Mass Index ,Allergic inflammation ,FEV1/FVC ratio ,Forced Expiratory Volume ,Internal medicine ,Bronchodilation ,medicine ,Humans ,Immunology and Allergy ,Respiratory system ,Child ,Skin Tests ,Asthma ,Pharmacology ,medicine.diagnostic_test ,business.industry ,Rhinitis, Allergic, Seasonal ,Forced Expiratory Flow Rates ,respiratory system ,medicine.disease ,Bronchodilator Agents ,Respiratory Function Tests ,respiratory tract diseases ,Female ,medicine.symptom ,business ,Body mass index - Abstract
Several studies have outlined a possible relationship between an increased body mass index and respiratory allergic diseases, such as asthma and rhinitis. The aim of the study was to analyse the relationship between BMI and lung function, including bronchodilation test, in allergic children. The study included 153 children (103 males, mean age 12.8 years) with allergic rhinitis and mild asthma. All subjects were evaluated performing skin prick test, spirometry, and bronchodilalation test. BMI values were in the normal range as well as lung function. BMI significantly related with FEV1, FVC values and FEV1/FVC ratio both before and after bronchodilation. In conclusion, this study provides the first evidence that BMI is negatively related with bronchial reversibility in children with allergic rhinitis and asthma. As reversibility is related with bronchial inflammation, this finding might underline a link between overweight and allergic inflammation.
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- 2011
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32. Bet v 1 sensitization modulates allergenic molecular 1 immune response
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Angela Pistorio, Michela Silvestri, Giorgio Ciprandi, P Del Barba, Roberta Olcese, and Mariangela Tosca
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Allergy ,biology ,business.industry ,Immunoglobulin E ,medicine.disease ,medicine.disease_cause ,Serum ige ,Large sample ,Allergen ,medicine.anatomical_structure ,Immune system ,Immunology ,biology.protein ,medicine ,Immunology and Allergy ,business ,Allergen specific IgE ,Sensitization - Abstract
Summary Background Allergy is characterized by allergen-specific IgE production. Molecular-based allergy diagnostic allows to define the precise sensitization profile. Bet v 1 is the major allergen of the PR-10 family. It has been reported that pan-allergens could affect the sensitization panel in adults. This study aimed to evaluate the impact of Bet v 1 sensitization on sensitization pattern in a large sample of children. Methods Serum IgE molecular components were assessed by ISAC method. Sera from 1,205 children, 708 males (58.76%) and 497 females (41.24%), median age 8.61 years (4.93 - 12.54 years) were analyzed. Results A total of 354 PR-10-positive subjects were detected out of 1,205 subjects. Bet v 1 positive children were significantly more frequently sensitized to other molecules belonging to PR-10 family and noteworthy also to other allergenic families than Bet v 1 negative children. Conclusions The present study demonstrates that Bet v 1 sensitization may significantly affect the sensitization pattern in children living in Genoa, a Mediterranean city located in a birch-free area.
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- 2019
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33. Bronchodilation test in patients with allergic rhinitis
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Mariangela Tosca, Alessio Signori, Giorgio Ciprandi, and I. Cirillo
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Spirometry ,Allergy ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Immunology ,Respiratory disease ,Physical examination ,medicine.disease ,Bronchodilatation ,Internal medicine ,Bronchodilation ,medicine ,Immunology and Allergy ,Risk factor ,business ,Asthma - Abstract
To cite this article: Ciprandi G, Signori A, Tosca MA, Cirillo I. Bronchodilation test in patients with allergic rhinitis. Allergy 2011; 66: 694–698. Abstract Background: Allergic rhinitis (AR) may be considered a risk factor for the onset of asthma. Recently, it has been reported that forced expiratory flow between 25% and 75% of vital capacity (FEF25–75) may predict a positive response to bronchodilation test in asthmatic children. The aim of this study was to evaluate a large group of adult AR patients to investigate the frequency of response to bronchodilation test and FEF25–75 values. Methods: One thousand four hundred and sixty-nine consecutive patients suffering from persistent AR were evaluated. Clinical examination, spirometry, and bronchodilation test were performed in all patients. Results: In this study, 62.9% of patients had reversibility to bronchodilation test and 17.8% had impaired FEF25–75 values (≤65% of predicted). Impaired FEF25–75 values associated with longer rhinitis duration may predict reversibility to bronchodilation test (OR = 11.3; P
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- 2011
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34. Immunoglobulin Production Pattern in Allergic and Non-Allergic Subjects
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M. De Amici, Gian Luigi Marseglia, Giorgio Ciprandi, and Mariangela Tosca
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biology ,business.industry ,lcsh:R ,Immunology ,lcsh:Medicine ,Immunoglobulin E ,Immune system ,Non allergic ,otorhinolaryngologic diseases ,biology.protein ,Immunology and Allergy ,Medicine ,Antibody ,business ,Allergen specific IgG - Abstract
Allergic rhinitis (AR) is characterized by Th2 polarized immune response, such as increased IL-4 and reduced IFN-γ production, and by a functional defect of T regulatory cells. This impaired immune response profile influences the pattern of immunoglobulin (Ig) production in allergic patients. However, no studies have compared the pattern of inhalant allergen-specific Ig classes between allergic patients and normal subjects. The aim of this study is to therefore investigate the allergen-specific IgE, IgG, IgG4, and IgA serum level pattern in a group of patients with pollen allergy and in non-allergic healthy subjects. One hundred and two allergic patients (evaluated both out of and in the pollen season) were enrolled. In addition, 50 healthy non-allergic subjects were recruited during the whole year. Serum allergen-specific IgE, IgG, IgG4, and IgA for Parietaria, grasses, and birch were quantitatively determined by the ImmunoCAP System method. Allergen-specific IgE, IgG, IgG4, and IgA serum levels were significantly different for each tested allergen (p=0.0001 for each class) among groups. Allergic patients, mainly during pollen season, showed the highest IgG, IgG4, and IgA levels. The present study therefore provides the preliminary evidence that Ig production pattern toward inhalant allergens may depend on the specificity of the allergenic response both in non-allergic subjects and allergic patients Allergic patients do not show a defect of IgG and IgA classes. In addition, this study is the first that quantitatively evaluates the Ig classes. However, further studies should include non-allergic subjects evaluated both during and out of the pollen season.
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- 2010
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35. Neutrophilic Cells in Sputum of Allergic Asthmatic Children
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M. Miraglia Del Giudice, F. P. Brunese, Carlo Capristo, Salvatore Leonardi, Giorgio Ciprandi, Mariangela Tosca, M. Pedullà, and Capristo A
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business.industry ,lcsh:R ,Immunology ,Airway inflammation ,lcsh:Medicine ,Induced sputum ,Eosinophil ,medicine.disease ,respiratory tract diseases ,Asthmatic children ,medicine.anatomical_structure ,Eosinophilic infiltrate ,medicine ,Immunology and Allergy ,Sputum ,medicine.symptom ,Atopic asthma ,business ,Asthma - Abstract
Airway inflammation is regarded as a central feature of asthma and is mostly sustained by eosinophilic infiltrate. Recent studies have shown that a co-activation of eosinophil- and neutrophil-dependent inflammatory mechanisms might explain why some asthmatics do not respond to conventional asthma therapy. The aim of our study is to determine whether neutrophilic inflammation was involved in 55 allergic children with mild-moderate persistent asthma and the relationship with the response to steroid treatment. Before the sputum analysis, all children underwent spirometry with the reversibility test, and were divided into two groups on the basis of the response (such as >12% of baseline FEV1): group 1 positive and group 2 negative. Eosinophil cationic protein concentrations were measured by radioimmunoassay and neutrophyl myeloperoxidase (MPO) concentrations were measured by an MPO-EIA. Ten healthy children of comparable ages served as control group. Total IgE, FEV1 and FEV/FVC values were similar in both groups. The sputum macrophage count was higher in controls than in allergic asthmatics, but there was no difference between groups 1 and 2 (59.6% vs 18.3% and 17%; p≤ 0.005). Sputum neutrophils were significantly higher in group 2 both vs controls (62% vs 34%; p≤ 0.005) and vs group 1 (62% vs 37%; p≤ 0.005). Our data suggest that neutrophils are involved in airway allergic inflammation in mild-moderate persistent childhood asthma and a high neutrophil count in sputum may be related to a lower responsiveness to inhaled corticosteroids.
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- 2010
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36. Serum adiponectin levels in patients with seasonal allergic rhinitis
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Gian Luigi Marseglia, Mara De Amici, Giorgio Ciprandi, and Mariangela Tosca
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Adult ,Male ,medicine.medical_specialty ,Allergy ,Adolescent ,Immunology ,Physiology ,Pilot Projects ,medicine.disease_cause ,Body Mass Index ,Allergen ,Pollen ,Immunopathology ,Internal medicine ,Humans ,Immunology and Allergy ,Medicine ,Aged ,Skin Tests ,Pharmacology ,Adiponectin ,business.industry ,Rhinitis, Allergic, Seasonal ,Antigens, Plant ,Middle Aged ,medicine.disease ,Endocrinology ,Toxicity ,Cohort ,Female ,Seasons ,business ,Blood sampling - Abstract
Background A few studies have outlined a possible relationship between an increased body mass index and allergic rhinitis. A single study reported that males with seasonal allergic rhinitis (SAR), evaluated outside the pollen season, had increased serum adiponectin levels. Objective The aim of this preliminary study was to evaluate the serum adiponectin levels in a cohort of SAR normo-weight patients evaluated during the pollen season, comparing them with SAR patients evaluated out of pollen season and a group of healthy controls. Methods The study included 137 subjects; 62 SAR patients evaluated in their pollen season, while symptomatic, 41 SAR patients studied out their pollen season, while they were without symptoms, and 34 normal subjects. All subjects were consecutively evaluated. All of them were normo-weight. A skin prick test and blood sampling for assessing serum adiponectin levels were performed in all subjects. Results After analysing genders separately, symptomatic male patients had significantly higher levels than both symptomless and normal males ( p = 0.0041 and 0.0001 respectively), symptomatic female patients showed significantly higher levels than both symptomless and normal females ( p = 0.0001 and 0.0071 respectively). Conclusion This study provides the preliminary evidence that adiponectin serum levels might depend on allergen exposure in SAR normo-weight patients.
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- 2010
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37. Serum Transforming Growth Factor-β Levels Depend on Allergen Exposure in Allergic Rhinitis
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Mara De Amici, Gian Luigi Marseglia, Giorgio Ciprandi, and Mariangela Tosca
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Adult ,Male ,medicine.medical_specialty ,Allergy ,medicine.medical_treatment ,Immunology ,Administration, Sublingual ,Inflammation ,Poaceae ,medicine.disease_cause ,Pathogenesis ,Allergen ,Immune system ,Transforming Growth Factor beta ,Internal medicine ,Immunopathology ,Humans ,Immunology and Allergy ,Medicine ,Desensitization (medicine) ,business.industry ,Rhinitis, Allergic, Seasonal ,General Medicine ,Allergens ,medicine.disease ,Parietaria ,Endocrinology ,Desensitization, Immunologic ,Pollen ,Female ,medicine.symptom ,business ,Transforming growth factor - Abstract
Background:Allergic rhinitis (AR) is characterized by inflammation sustained by dysregulated immune response. T-regulatory cells are involved in AR pathogenesis, mainly producing IL-10 and transforming growth factor (TGF)-β. Indeed, there is a functional and allergen-specific defect of T-regulatory cells in AR. However, there are no data about the influence of allergen exposure on TGF-β serum levels. Therefore, the aim of this preliminary study was to evaluate TGF-β serum levels in patients with seasonal AR. Patients were evaluated either outside the pollen season and after 1 preseasonal sublingual immunotherapy (SLIT) course (38 subjects) or during the pollen season (57 subjects). Methods:All patients were allergic to Parietaria and/or grasses alone. TGF-β was measured by a commercially available kit. Symptoms, drug use and eosinophils were evaluated.Serum allergen-specific IgG and IgA levels were also measured by the ELISA method. Results:TGF-β serum levels were significantly lower in patients evaluated outside the pollen season in comparison with the other 2 situations. SLIT induced the significantly highest TGF-β serum levels. There was a significant negative relationship between TGF-β and eosinophils in patients after SLIT. IgG and IgA levels were higher in SLIT-treated patients. Conclusion: This preliminary study provides evidence that TGF-β serum levels are significantly dependent on allergen exposure.
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- 2009
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38. Relationship between Responses to Bronchodilation Testing and to Nasal Decongestion Testing in Patients with Allergic Rhinitis Alone
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I. Cirillo, Angela Pistorio, Mariangela Tosca, Gian Luigi Marseglia, and Giorgio Ciprandi
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Spirometry ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,lcsh:R ,Immunology ,lcsh:Medicine ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Feature (computer vision) ,030220 oncology & carcinogenesis ,Internal medicine ,Bronchodilation ,medicine ,Cardiology ,Immunology and Allergy ,In patient ,Rhinomanometry ,030223 otorhinolaryngology ,Bronchial obstruction ,business ,Asthma - Abstract
A remarkable relationship exists between upper and lower airways. Bronchial obstruction is a paramount feature of asthma as well as nasal obstruction of allergic rhinitis (AR). This study aims to evaluate the response to both bronchodilation and decongestion testing and their relationships in a large group of patients with moderate-severe persistent AR alone. Two hundred eleven patients with moderate-severe persistent AR were prospectively and consecutively evaluated. Clinical examination, skin prick test, spirometry, bronchodilation test, rhinomanometry, and decongestion test were performed on all patients. Seventeen subjects (8%) did not respond to any of the tests, 55 subjects (26.1%) were responders only to the decongestion test, 31 (14.7%) only to the bronchodilation test, and 108 subjects (51.2%) responded to both these tests. Longer AR duration was significantly associated with positive response to both tests (p
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- 2009
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39. Impact of allergic rhinitis on asthma: effects on bronchial hyperreactivity
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Ignazio Cirillo, Mariangela Tosca, Giorgio Ciprandi, and Angela Pistorio
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Adult ,Male ,Spirometry ,Allergy ,medicine.medical_specialty ,Immunology ,Bronchial Provocation Tests ,Risk Factors ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,Risk factor ,Sensitization ,Rhinitis ,Skin Tests ,Asthma ,Bronchus ,medicine.diagnostic_test ,business.industry ,Respiratory disease ,medicine.disease ,medicine.anatomical_structure ,Female ,Methacholine ,Bronchial Hyperreactivity ,business ,medicine.drug - Abstract
Background: Remarkable relationship exists between upper and lower airways. Bronchial hyperreactivity (BHR) is a paramount feature of asthma and may be considered a strong risk factor for the onset of asthma in patients with allergic rhinitis. Objective: This study is aimed at evaluating the presence of BHR in a large group of patients with moderate-severe persistent allergic rhinitis alone, and at investigating possible risk factors related to severe BHR. Methods: Three hundred and forty-two patients with moderate-severe persistent allergic rhinitis were prospectively and consecutively evaluated. Clinical examination, skin prick test, spirometry and bronchial methacholine (MCH) test were performed in all patients. Results: Twenty-two (6.4%) patients had severe BHR, 74 (21.6%) patients had mild BHR and 192 (56.2%) had borderline BHR; 54 (15.8%) patients had a negative MCH test. The logistic regression analysis evidenced that trees and house dust mites sensitization (ORAdj: 8.1), rhinitis duration > 5 years (ORAdj: 5.4) and FEV1 ≤ 86% of predicted (ORAdj: 4.0) were significantly associated with severe BHR. The discriminative ability of this model is appreciably satisfactory, being the AUC = 0.90. Conclusion: This study highlights the close link between upper and lower airways and the role of some risk factors, such as tree and mite sensitization, > 5-year duration, and ≤ 86% FEV1 values, as risk factors for severe BHR in patients with moderate-severe persistent allergic rhinitis alone. Therefore, BHR is frequently present in patients with chronic rhinitis and should be suspected in the presence of defined risk factors.
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- 2009
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40. Body mass index, respiratory function and bronchial hyperreactivity in allergic rhinitis and asthma
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Mariangela Tosca, Ignazio Cirillo, Maria Rosaria Ferraro, Angela Pistorio, and Giorgio Ciprandi
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Spirometry ,Adult ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Allergy ,Rhinitis, Allergic, Perennial ,Risk Assessment ,Allergic rhinitis ,Bronchial Provocation Tests ,Body Mass Index ,Bronchoconstrictor Agents ,Sex Factors ,Internal medicine ,Forced Expiratory Volume ,Administration, Inhalation ,medicine ,Humans ,Respiratory function ,Methacholine Chloride ,Asthma ,Skin Tests ,medicine.diagnostic_test ,business.industry ,medicine.disease ,Military Personnel ,Cohort ,Immunology ,Methacholine ,Female ,Rhinomanometry ,Bronchial Hyperreactivity ,business ,Body mass index ,medicine.drug - Abstract
SummaryBackgroundSeveral studies have outlined a possible relationship between an increased body mass index (BMI) and respiratory allergic diseases, such as asthma and rhinitis.The aim of the study was to analyse the relationship between BMI and allergic diseases, including allergic rhinitis and asthma, and functional parameters, such as nasal airflow, FEV1, and non-specific BHR to methacholine, in a cohort of navy army subjects.MethodsThe study included 100 patients with moderate–severe persistent allergic rhinitis alone, 100 with intermittent allergic asthma alone, and 100 healthy controls. All subjects were evaluated performing skin prick test, spirometry, and bronchostimulation test with methacholine. Rhinomanometry was performed in patients with rhinitis.ResultsBMI values were significantly lower in control subjects with respect to patients with rhinitis (P=0.0002) and with respect to patients with asthma (P
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- 2009
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41. The asthma control in daily practice
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Mohsen Sadatsafavi, Mariangela Tosca, Fabio Luigi Massimo Ricciardolo, I. Cirillo, Giorgio Ciprandi, J. Mark FitzGerald, and Fabio Gallo
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medicine.medical_specialty ,business.industry ,Immunology ,Asthma ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,Daily practice ,Asthma control ,Administration, Inhalation ,Physical therapy ,Humans ,Immunology and Allergy ,Medicine ,Anti-Asthmatic Agents ,030212 general & internal medicine ,business - Published
- 2016
42. Efficacy ofBacillus clausiispores in the prevention of recurrent respiratory infections in children: a pilot study
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Giorgio Ciprandi, Gian Luigi Marseglia, Ignazio Cirillo, Mariangela Tosca, Amelia Licari, M. Leone, Alessia Marseglia, and Anna Maria Castellazzi
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Allergy ,Pediatrics ,medicine.medical_specialty ,Chemical Health and Safety ,biology ,business.industry ,Bacillus clausii ,General Medicine ,allergy ,biology.organism_classification ,medicine.disease ,law.invention ,respiratory infections ,Probiotic ,children ,law ,medicine ,Recurrent respiratory infections ,Pharmacology (medical) ,General Pharmacology, Toxicology and Pharmaceutics ,Respiratory system ,business ,Safety Research ,probiotic ,Original Research - Abstract
Probiotic milk has been previously demonstrated to reduce the number of respiratory infections (RI) among children attending day care centres. Thus, this pilot study was aimed to assess the efficacy and the safety of 3 month treatment with Bacillus clausii in the prevention of recurrent respiratory infections (RRI) in children. Eighty children with RRI were studied: 40 of them were randomly treated with B. clausii for 3 months, and followed up for further 3 months; 40 were included in the control group during the same period. Children treated with B. clausii had shorter duration of RI in comparison with the control group both during the treatment phase (mean 11.7 days vs 14.37; p=0.037) and the follow-up period (mean 6.6 days vs 10.92; p=0.049). This effect was evident also in allergic children during the follow-up. In conclusion, this pilot study provides the first preliminary evidence that B. clausii may exert a significant and persistent impact on RI in children and is safe and well tolerated.
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- 2007
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43. Airway function and nasal inflammation in seasonal allergic rhinitis and asthma
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Giorgio Ciprandi, Ignazio Cirillo, Mariangela Tosca, Andrea Vizzaccaro, and Manlio Milanese
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Adult ,Male ,Spirometry ,Allergy ,Immunology ,Mucous membrane of nose ,Interferon-gamma ,Forced Expiratory Volume ,otorhinolaryngologic diseases ,medicine ,Humans ,Immunology and Allergy ,Lung ,Asthma ,medicine.diagnostic_test ,business.industry ,Rhinitis, Allergic, Seasonal ,respiratory system ,Eosinophil ,Nasal Lavage Fluid ,medicine.disease ,Rhinomanometry ,respiratory tract diseases ,Eosinophils ,Nasal Mucosa ,medicine.anatomical_structure ,Regression Analysis ,Nasal Lavage ,Female ,Interleukin-4 ,Nasal Obstruction ,business - Abstract
Summary Background Allergic rhinitis (AR) and asthma are frequently associated and characterized by a Th2-dependent inflammation. Nasal and bronchial obstruction may be objectively measured. Objective The aim of this study was to evaluate the relationships among upper and lower airway function and nasal inflammation in subjects with seasonal allergic rhinitis (SAR) and asthma. Methods Twenty out-patients (12 males and eight females, mean age: 23.4+3.6 years) with SAR and asthma were evaluated during the pollen season. All of them showed a moderate–severe grade of nasal obstruction. Total symptom score, rhinomanometry, spirometry, nasal lavage, and nasal scraping were obtained in all subjects. Eosinophils were counted by conventional staining; IL-4 and IFN-γ were measured by immunoassay on fluids recovered from nasal lavage. Results Functional parameters, i.e. nasal airflow and forced expiratory volume in 1 s (FEV1), were correlated with nasal eosinophils (R2>0.83, P
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- 2004
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44. Asthma and COPD exacerbations: An 8year survey
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Giorgio Ciprandi, Irene Minetti, Mariangela Tosca, Silvano Ruffoni, and Silvana G. Dellepiane
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Adult ,Emergency Medical Services ,medicine.medical_specialty ,Adolescent ,MEDLINE ,Pulmonary disease ,Severity of Illness Index ,Pulmonary Disease, Chronic Obstructive ,Young Adult ,Internal medicine ,Severity of illness ,Internal Medicine ,medicine ,Humans ,Young adult ,Child ,Asthma ,COPD ,Asthma therapy ,business.industry ,Infant, Newborn ,Infant ,Middle Aged ,medicine.disease ,Italy ,Child, Preschool ,business - Published
- 2011
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45. Peanut anaphylaxis: the usefulness of molecular-based allergy diagnostics
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G. A. Rossi, Giorgio Ciprandi, Michela Silvestri, Angela Pistorio, and Mariangela Tosca
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medicine.medical_specialty ,Allergy ,business.industry ,Immunology ,Reproducibility of Results ,Allergens ,Immunoglobulin E ,medicine.disease ,Dermatology ,Sensitivity and Specificity ,Antibody Specificity ,medicine ,Immunology and Allergy ,Humans ,Peanut Hypersensitivity ,business ,Anaphylaxis - Published
- 2014
46. Egg allergy: the relevance of molecular-based allergy diagnostics
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Mariangela Tosca, G. A. Rossi, Andrea Accogli, Michela Silvestri, Angela Pistorio, and Giorgio Ciprandi
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Male ,Allergy ,business.industry ,Immunology ,Immunoglobulin E ,medicine.disease ,Desensitization, Immunologic ,Egg allergy ,Immunology and Allergy ,Medicine ,Humans ,Relevance (information retrieval) ,Female ,business ,Egg Hypersensitivity - Published
- 2014
47. Long-term cetirizine treatment reduces allergic symptoms and drug prescriptions in children with mite allergy
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Giorgio Walter Canonica, Mariangela Tosca, Giorgio Ciprandi, and Giovanni Passalacqua
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Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Allergy ,Time Factors ,Immunology ,Placebo ,medicine.disease_cause ,Asymptomatic ,Allergen ,Double-Blind Method ,Internal medicine ,Anti-Allergic Agents ,Hypersensitivity ,medicine ,Animals ,Humans ,Immunology and Allergy ,Child ,Asthma ,Mites ,rhinorrhea ,business.industry ,Aeroallergen ,Allergens ,medicine.disease ,Cetirizine ,Treatment Outcome ,Anesthesia ,Female ,medicine.symptom ,business ,medicine.drug - Abstract
Experimental data demonstrate that mite allergy is characterized by persistent chronic inflammation, even during asymptomatic periods. This suggests that long-term continuous treatment be included in the global strategy of allergy treatment.We conducted a study to evaluate whether regularly administered cetirizine reduces allergic symptoms and drug prescriptions in children with mite allergy.In this double-blind, randomized, placebo-controlled study, two parallel groups of 10 children with mite allergy (mean age: 6.5 years) received either cetirizine or placebo daily for 6 months. Participants were allowed to take rescue medications for rhinitis and/or mild asthma. The symptoms (nasal itching, sneezing, obstruction, rhinorrhea, conjunctival itching, lacrimation, conjunctival hyperemia, cough, wheezing, and chest tightness) were recorded on a diary card. The intake of cetirizine (as additional symptomatic treatment), antibiotics, acetaminophen, beta2-agonists, inhaled and systemic corticosteroids was also recorded.Symptom scores and drug consumption were significantly lower (P0.05) in the cetrizine-treated group versus the placebo group. The greatest reductions were in cetirizine itself, inhaled corticosteroids, beta2-agonists, and antibiotics. No side effects were reported in either group.In mite-allergic children, cetirizine administered daily for prolonged periods decreases symptoms of and drug prescriptions for allergic rhinitis and asthma compared with symptomatic treatment.
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- 2001
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48. Interferon-gamma and IL-10 may protect from allergic polysensitization in children: preliminary evidence
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Michela Silvestri, G. A. Rossi, Vito Pistoia, Giorgio Ciprandi, Mariangela Tosca, Fabio Morandi, and I. Prigione
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Allergy ,Allergic reaction ,business.industry ,Immunology ,Follow up studies ,Interferon-gamma biosynthesis ,medicine.disease ,Interleukin 10 ,medicine ,Immunology and Allergy ,Interferon gamma ,business ,medicine.drug - Abstract
To cite this article: Prigione I, Morandi F, Tosca MA, Silvestri M, Pistoia V, Ciprandi G, Rossi GA. Interferon-gamma and IL-10 may protect from allergic polysensitization in children: preliminary evidence. Allergy 2010; 65: 740–742. Abstract Background: A functional defect of T regulatory cells (Treg) has been proposed as pathogenic mechanism of allergic reaction. Polysensitization is a common feature of allergic patients. Aim of the study: It was to investigate the possible role of Treg-Th1 cytokines, in the development of new sensitizations in childhood. Methods: Forty monosensitized (MS) children with allergic rhinitis were evaluated and followed-up for 2 years. New sensitizations were investigated. IL-10 and IFN-γ were evaluated in in vitro experiments. Results: Children remaining MS showed significant higher production of both IL-10 and IFN-γ. Conclusion: This preliminary study provided evidence that IL-10 and IFN-γ production could be defective in allergic children prone to develop polysensitization.
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- 2009
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49. Food anaphylaxis in children: Peculiarity of characteristics
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Mariangela Tosca, Angela Pistorio, Giorgio Ciprandi, Andrea Accogli, and Giovanni A. Rossi
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Pulmonary and Respiratory Medicine ,Male ,medicine.medical_specialty ,business.industry ,Immunology ,Infant ,General Medicine ,Surgery ,Italy ,Risk Factors ,Food anaphylaxis ,Child, Preschool ,medicine ,Prevalence ,Immunology and Allergy ,Humans ,Female ,business ,Intensive care medicine ,Child ,Anaphylaxis ,Food Hypersensitivity - Published
- 2014
50. Asthma exacerbation in children: relationship among pollens, weather, and air pollution
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Giorgio Walter Canonica, S Ruffoni, Giorgio Ciprandi, and Mariangela Tosca
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Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Parietaria ,Exacerbation ,Immunology ,Air pollution ,medicine.disease_cause ,Air pollutants ,Air Pollution ,medicine ,Humans ,Immunology and Allergy ,Child ,Intensive care medicine ,Weather ,Pollen count ,Asthma ,Asthma exacerbations ,biology ,business.industry ,General Medicine ,biology.organism_classification ,medicine.disease ,Urticaceae ,Italy ,Pollen ,Female ,Seasons ,business ,Demography - Abstract
Background Asthma exacerbation is an episode of (sub)acute worsening of asthmatic symptoms. Exacerbation may depend on environmental factors. Objective The present study investigated emergency calls for asthma exacerbation in children, analysing: i) their trend over the course of time; and ii) their possible relationship with environmental factors, including pollen count, meteorological parameters, and air pollution. Methods Emergency calls for exacerbation were recorded for 10 years (from 2002 to 2011) in Genoa (Italy). Betulaceae, Urticaceae, Gramineae, and Oleaceae pollen counts were measured. Meteorological parameters and air pollutants were also measured in the same area and for the same period. Results The number of emergency calls did not significantly modify during the time studied. Two main peaks were detected: during the autumn and the spring. Wind speed significantly diminished as did most air pollutants. There were significant and relevant relationships between emergency calls and: pollens during the spring ( r = 0.498), rainfall ( r = 0.818), wind speed ( r = 0.727), and air pollutants ( r = 0.622 for SO 2 ; r = 0.699 for NO; r = 0.58 for NO 2 ). Conclusions This 10-year survey demonstrates that: (i) asthma exacerbations did not diminish over the time; (ii) there were seasonal peaks (autumn and spring); (iii) pollens (mainly Parietaria), wind speed and rainfall, SO 2 , NO, O 3 and NO 2 were strongly associated with asthma exacerbations in children in this area. Therefore, asthma exacerbations may significantly depend on environmental variations.
- Published
- 2014
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