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1. Acute gastrointestinal bleeding cases presenting to the emergency department are associated with age, sex and seasonal and circadian factors

Author

Bastian Schönemeier, Michael P. Manns, Eliane Musmann, Henrike Lenzen, Martina Kottas, Thomas Köhnlein, and Tim O. Lankisch

Subjects
Male, Pediatrics, Time Factors, Endoscopy, Gastrointestinal, Tertiary Care Centers, 0302 clinical medicine, Risk Factors, Germany, 030212 general & internal medicine, Aged, 80 and over, Univariate analysis, Incidence, Incidence (epidemiology), Hemostasis, Endoscopic, Age Factors, Gastroenterology, Middle Aged, Circadian Rhythm, Predictive value of tests, Acute Disease, Female, 030211 gastroenterology & hepatology, Seasons, Emergency Service, Hospital, Gastrointestinal Hemorrhage, Adult, medicine.medical_specialty, Gastrointestinal bleeding, Evening, Adolescent, Young Adult, 03 medical and health sciences, Sex Factors, After-Hours Care, Predictive Value of Tests, medicine, Humans, Weather, Aged, Retrospective Studies, Chi-Square Distribution, Hepatology, business.industry, Retrospective cohort study, Emergency department, medicine.disease, Confidence interval, Logistic Models, Multivariate Analysis, business
Abstract

BACKGROUND Gastrointestinal bleeding (GIB) is one of the most common emergencies in gastroenterology. The aim of this study was to investigate the association between the incidence of GIB and seasonal, circadian and meteorological patterns in the emergency department (ED) of a tertiary hospital. PATIENTS AND METHODS From January 2007 until December 2012, we retrospectively evaluated patients presenting to the ED with respect to the number and location of GIB, season, time of day and weather. RESULTS Of 45 458 patients, 578 (1.3%) presented with a GIB. Of these, 62.5% were men compared with 54.7% of all patients in the ED (χ, P=0.0002). Patients with GIB were on average 4.4 years older than those without GIB (95% confidence interval 2.76-5.98, t-test, P

Published
2017
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2. Risk estimation for biliary tract cancer: Development and validation of a prognostic score

Author

Sarah Berhane, Philip J. Johnson, Marianne Sinn, Zeynep Balta, Mareike Fischer, Tobias J. Weismüller, Christian P. Strassburg, Arndt Vogel, Martina Kottas, Tanja Reineke-Plaaß, Arndt Weinmann, Nora Schweitzer, Michael P. Manns, Hüseyin Bektas, Maria A. Gonzalez-Carmona, and Martha M. Kirstein

Subjects
Oncology, Male, medicine.medical_specialty, Risk Assessment, Prognostic score, Metastasis, Cholangiocarcinoma, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Germany, medicine, Humans, Aged, Biliary tract neoplasm, Biliary tract cancer, Hepatology, business.industry, Proportional hazards model, Middle Aged, medicine.disease, Prognosis, Surgery, Biliary Tract Neoplasms, 030220 oncology & carcinogenesis, Cohort, 030211 gastroenterology & hepatology, Female, Risk assessment, business, Cohort study
Abstract

Background & Aims Biliary tract cancer is a rare tumour entity characterized by a poor prognosis. We aimed to identify prognostic factors and create a prognostic score to estimate survival. Methods Clinical data of the training set, consisting of 569 patients treated from 2000 to 2010 at Hannover Medical School, were analysed. A prognostic model defining three prognostic risk groups was derived from Cox regression analyses. The score was applied and validated in an independent cohort of 557 patients from four different German centres. Results Median overall survival (OS) was 14.5 months. If complete resection was performed, the patients had a significantly improved OS (23.9 months; n=242) as compared to patients with non-resectable tumours (9.1 months; n=329, P

Published
2017

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