13 results on '"Mary Wallis"'
Search Results
2. Supporting breastfeeding mothers in hospital: part 2b
- Author
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Mary Wallis and Margaret Harper
- Subjects
Heart Defects, Congenital ,Hospitalization ,Breast Feeding ,Face ,Skull ,Infant, Newborn ,Humans ,Social Support ,Female ,General Medicine - Abstract
In this third article in the series, two further hypothetical scenarios are used to provide guidance on supporting breastfeeding mothers when the baby has a craniofacial anomaly or a cardiac defect. Successful breastfeeding in such circumstances has a positive effect on maternal confidence and attachment, and appears in itself to have healing potential. Unexpected benefits of breastfeeding critically ill babies include enhanced immunity and feeding tolerance in babies undergoing chemotherapy. A structured breastfeeding support service can assist staff in promoting successful breastfeeding in the paediatric environment. Expert, experiential knowledge of overcoming challenges in breastfeeding for mothers of critically ill babies can be applied in the absence of research evidence.
- Published
- 2007
3. Supporting breastfeeding mothers in hospital: part 1
- Author
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Margaret Harper and Mary Wallis
- Subjects
Postnatal Care ,medicine.medical_specialty ,Inservice Training ,Decision Making ,Breastfeeding ,Mothers ,Health Promotion ,Nursing Staff, Hospital ,Nurse's Role ,Institutional support ,Social support ,Education, Nursing, Continuing ,Nursing ,London ,Humans ,Medicine ,Program Development ,Breastfeeding support ,Information Services ,Service (business) ,Internet ,Health Priorities ,business.industry ,Public health ,Infant, Newborn ,Delayed onset ,Social Support ,General Medicine ,Hospitals, Pediatric ,Organizational Policy ,Pediatric Nursing ,Benchmarking ,Breast Feeding ,Practice Guidelines as Topic ,Anxiety ,Female ,Public Health ,medicine.symptom ,business - Abstract
Breastfeeding makes a vital contribution to the health and development of babies, as well as to long term health. Establishing breastfeeding may not be easy even for mothers with healthy full-term babies. Mothers in the paediatric environment experience additional challenges: sick babies, delayed onset of breastfeeding and having to establish and maintain breastfeeding in situations where privacy may be limited and anxiety levels high. This first part of a two-part article describes the development of a breastfeeding support service in a tertiary children's hospital. Institutional support, a dedicated post and a planned programme of training and education, with the development of specific resource materials, have resulted in a service that closely matches the expressed needs of mothers.
- Published
- 2007
4. Sex determination in mammals--before and after the evolution of SRY
- Author
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Paul D. Waters, Jennifer A. Marshall Graves, and Mary Wallis
- Subjects
Monotreme ,Birds ,Evolution, Molecular ,Cellular and Molecular Neuroscience ,Gene mapping ,biology.animal ,parasitic diseases ,Animals ,Molecular Biology ,Pharmacology ,Genetics ,Mammals ,Autosome ,Sex Chromosomes ,biology ,Chromosome ,Cell Biology ,Sex Determination Processes ,biology.organism_classification ,Sex-Determining Region Y Protein ,Testis determining factor ,Evolutionary biology ,Echidna ,Molecular Medicine ,Mammal ,Platypus - Abstract
Therian mammals (marsupials and placentals) have an XX female: XY male sex chromosome system, which is homologous to autosomes in other vertebrates. The testis-determining gene, SRY, is conserved on the Y throughout therians, but is absent in other vertebrates, suggesting that the mammal system evolved about 310 million years ago (MYA). However, recent work on the basal monotreme mammals has completely changed our conception of how and when this change occurred. Platypus and echidna lack SRY, and the therian X and Y are represented by autosomes, implying that SRY evolved in therians after their divergence from monotremes only 166 MYA. Clues to the ancestral mechanism usurped by SRY in therians are provided by the monotremes, whose sex chromosomes are homologous to the ZW of birds. This suggests that the therian X and Y, and the SRY gene, evolved from an ancient bird-like sex chromosome system which predates the divergence of mammals and reptiles 310 MYA.
- Published
- 2008
5. Sex determination in platypus and echidna: autosomal location of SOX3 confirms the absence of SRY from monotremes
- Author
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Paul D. Waters, Willem Rens, Mary Wallis, Malcolm A. Ferguson-Smith, Frank Grützner, Margaret L. Delbridge, Andrew J Pask, Jennifer A. Marshall Graves, and Patrick J. Kirby
- Subjects
X Chromosome ,Tachyglossidae ,Molecular Sequence Data ,Y chromosome ,Monotreme ,Chromosome Painting ,biology.animal ,Y Chromosome ,parasitic diseases ,Genetics ,Animals ,Amino Acid Sequence ,Platypus ,X chromosome ,In Situ Hybridization, Fluorescence ,Prototheria ,Autosome ,biology ,Sequence Homology, Amino Acid ,SOXB1 Transcription Factors ,High Mobility Group Proteins ,Sex Determination Processes ,biology.organism_classification ,Sex-Determining Region Y Protein ,DNA-Binding Proteins ,Testis determining factor ,Echidna ,Transcription Factors - Abstract
In eutherian ('placental') mammals, sex is determined by the presence or absence of the Y chromosome-borne gene SRY, which triggers testis determination. Marsupials also have a Y-borne SRY gene, implying that this mechanism is ancestral to therians, the SRY gene having diverged from its X-borne homologue SOX3 at least 180 million years ago. The rare exceptions have clearly lost and replaced the SRY mechanism recently. Other vertebrate classes have a variety of sex-determining mechanisms, but none shares the therian SRY-driven XX female:XY male system. In monotreme mammals (platypus and echidna), which branched from the therian lineage 210 million years ago, no orthologue of SRY has been found. In this study we show that its partner SOX3 is autosomal in platypus and echidna, mapping among human X chromosome orthologues to platypus chromosome 6, and to the homologous chromosome 16 in echidna. The autosomal localization of SOX3 in monotreme mammals, as well as non-mammal vertebrates, implies that SRY is absent in Prototheria and evolved later in the therian lineage 210-180 million years ago. Sex determination in platypus and echidna must therefore depend on another male-determining gene(s) on the Y chromosomes, or on the different dosage of a gene(s) on the X chromosomes.
- Published
- 2007
6. Search for the sex-determining switch in monotremes: mapping WT1, SF1, LHX1, LHX2, FGF9, WNT4, RSPO1 and GATA4 in platypus
- Author
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Jennifer A. Marshall Graves, Patricia C. M. O’Brien, Willem Rens, Oliver Clarke, Mary Wallis, Daria Grafodatskaya, Malcolm A. Ferguson-Smith, and Vladimir A. Trifonov
- Subjects
Fibroblast Growth Factor 9 ,Male ,Chromosomes, Artificial, Bacterial ,Steroidogenic Factor 1 ,Wnt4 Protein ,biology.animal ,parasitic diseases ,WNT4 ,Genetics ,Homologous chromosome ,Animals ,Humans ,RSPO1 ,Platypus ,Gene ,Metaphase ,Homeodomain Proteins ,Autosome ,biology ,Models, Genetic ,Sex Determination Processes ,Human genetics ,GATA4 Transcription Factor ,Wnt Proteins ,Testis determining factor ,Gene Expression Regulation ,Female ,Thrombospondins - Abstract
The duck-billed platypus has five pairs of sex chromosomes, but there is no information about the primary sex-determining switch in this species. As there is no apparent SRY orthologue in platypus, another gene must acquire the function of a key regulator of the gonadal male or female fate. SOX9 was ruled out from being this key regulator as it maps to an autosome in platypus. To check whether other genes in mammalian gonadogenesis could be the primary switch in monotremes, we have mapped a number of candidates in platypus. We report here the autosomal location of WT1, SF1, LHX1, LHX9, FGF9, WNT4 and RSPO1 in platypus, thus excluding these from being key regulators of sex determination in this species. We found that GATA4 maps to sex chromosomes Y1 and X2; however, it lies in the pairing region shown by chromosome painting to be homologous, so is unlikely to be either male-specific or differentially dosed in male and female.
- Published
- 2007
7. Mammalian sex--Origin and evolution of the Y chromosome and SRY
- Author
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Jennifer A. Marshall Graves, Paul D. Waters, and Mary Wallis
- Subjects
Male ,X Chromosome ,Biology ,Y chromosome ,Molecular evolution ,Y Chromosome ,Animals ,Humans ,Genes, sry ,X chromosome ,Genetics ,Mammals ,Chromosomes, Human, X ,Sexual differentiation ,Chromosomes, Human, Y ,High Mobility Group Proteins ,SOX9 Transcription Factor ,Cell Biology ,Sex Determination Processes ,Biological Evolution ,Sex-Determining Region Y Protein ,Testis determining factor ,DMRT1 Gene ,Evolutionary biology ,Female ,Heterogametic sex ,Sex linkage ,Developmental Biology ,Transcription Factors - Abstract
Sex determination in vertebrates is accomplished through a highly conserved genetic pathway. But surprisingly, the downstream events may be activated by a variety of triggers, including sex determining genes and environmental cues. Amongst species with genetic sex determination, the sex determining gene is anything but conserved, and the chromosomes that bear this master switch subscribe to special rules of evolution and function. In mammals, with a few notable exceptions, female are homogametic (XX) and males have a single X and a small, heterochromatic and gene poor Y that bears a male dominant sex determining gene SRY. The bird sex chromosome system is the converse in that females are the heterogametic sex (ZW) and males the homogametic sex (ZZ). There is no SRY in birds, and the dosage-sensitive Z-borne DMRT1 gene is a credible candidate sex determining gene. Different sex determining switches seem therefore to have evolved independently in different lineages, although the complex sex chromosomes of the platypus offer us tantalizing clues that the mammal XY system may have evolved directly from an ancient reptile ZW system. In this review we will discuss the organization and evolution of the sex chromosomes across a broad range of mammals, and speculate on how the Y chromosome, and SRY, evolved.
- Published
- 2006
8. Mapping platypus SOX genes; autosomal location of SOX9 excludes it from sex determining role
- Author
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Jennifer A. Marshall Graves, Mary Wallis, Malcolm A. Ferguson-Smith, Margaret L. Delbridge, Amber E. Alsop, Andrew J Pask, Patricia C. M. O’Brien, Willem Rens, and Frank Grützner
- Subjects
Chromosomes, Artificial, Bacterial ,SOX9 ,Chromosome Painting ,Chromosome 15 ,Gene mapping ,biology.animal ,parasitic diseases ,Gene duplication ,Genetics ,Animals ,Platypus ,Molecular Biology ,Gene ,Genetics (clinical) ,biology ,SOXE Transcription Factors ,High Mobility Group Proteins ,SOX9 Transcription Factor ,Sex Determination Processes ,Physical Chromosome Mapping ,Chromosomes, Mammalian ,Chromosome 17 (human) ,DNA-Binding Proteins ,Testis determining factor ,Transcription Factors - Abstract
In the absence of an SRY orthologue the platypus sex determining gene is unknown, so genes in the human testis determining pathway are of particular interest as candidates. SOX9 is an attractive choice because SOX9 deletions cause male-to-female sex reversal in humans and mice, and SOX9 duplications cause female-to-male sex reversal. We have localized platypus SOX9, as well as the related SOX10, to platypus chromosomes 15 and 10, respectively, the first assignments to these platypus chromosomes, and the first comparative mapping markers from human chromosomes 17 and 22. The autosomal localization of platypus SOX9 in this study contradicts the hypothesis that SOX9 acts as the sex determining switch in platypus.
- Published
- 2006
9. Fourth international symposium on the biology of vertebrate sex determination
- Author
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Mary Wallis, Andrew J Pask, and Tariq Ezaz
- Subjects
Genetics ,Sexual differentiation ,Downregulation and upregulation ,Meiosis ,biology ,Somatic cell ,biology.animal ,Cellular differentiation ,Gene expression ,Vertebrate ,Phenotype ,General Biochemistry, Genetics and Molecular Biology - Published
- 2006
10. Assignment of SOX1 to platypus chromosome 20q by fluorescence in situ hybridization
- Author
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Patrick J. Kirby, Frank Grützner, Amber E. Alsop, Mary Wallis, Margaret L. Delbridge, and Jennifer A. Marshall Graves
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Genetics ,biology ,medicine.diagnostic_test ,Nucleic acid sequence ,Chromosome ,Molecular biology ,HMGB Proteins ,SOX1 ,biology.animal ,medicine ,Gene sequence ,Molecular Biology ,Platypus ,Genetics (clinical) ,Fluorescence in situ hybridization - Published
- 2006
11. Search for the sex-determining switch in monotremes: Mapping WT1 , SF1 , LHX1 , LHX2 , FGF9 , WNT4 , RSPO1 and GATA4 in platypus.
- Author
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Daria Grafodatskaya, Willem Rens, Mary Wallis, Patricia OâBrien, Oliver Clarke, Jennifer Graves, and Malcolm Ferguson-Smith
- Abstract
Abstract  The duck-billed platypus has five pairs of sex chromosomes, but there is no information about the primary sex-determining switch in this species. As there is no apparent SRY orthologue in platypus, another gene must acquire the function of a key regulator of the gonadal male or female fate. SOX9 was ruled out from being this key regulator as it maps to an autosome in platypus. To check whether other genes in mammalian gonadogenesis could be the primary switch in monotremes, we have mapped a number of candidates in platypus. We report here the autosomal location of WT1, SF1, LHX1, LHX9, FGF9, WNT4 and RSPO1 in platypus, thus excluding these from being key regulators of sex determination in this species. We found that GATA4 maps to sex chromosomes Y1 and X2; however, it lies in the pairing region shown by chromosome painting to be homologous, so is unlikely to be either male-specific or differentially dosed in male and female. [ABSTRACT FROM AUTHOR]
- Published
- 2007
- Full Text
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12. Negative Myth-Making: Canada’s Self-Image and Its Implications for Scientific and Technological Development
- Author
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Scott Tiffin and Mary Wallis
- Subjects
Cultural Studies ,History ,media_common.quotation_subject ,Negativity effect ,Mythology ,Sociology ,Social science ,Pessimism ,Set (psychology) ,Self-image ,media_common ,Epistemology - Abstract
A survey of some 12,000 research scientists and engineers in Canada unexpectedly shows widespread pessimism about our future prospects in science and technology. Closer analysis, however, suggests that the negativity of responses only partly reflects the real situation. Instead, it appears that many researchers have been influenced by a fairly consistent set of values and beliefs that perpetuates a negative national self-image. This paper makes an exploratory, interdisciplinary study of Canada’s “cultural mythology” and its implications for future industrial development.
- Published
- 1989
13. The multiple sex chromosomes of platypus and echidna are not completely identical and several share homology with the avian Z
- Author
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Frédéric Veyrunes, Jennifer A. Marshall Graves, Frank Grützner, Patricia C. M. O’Brien, Steve Johnston, Malcolm A. Ferguson-Smith, Enkhjargal Tsend-Ayush, Willem Rens, Helen E. Skelton, Oliver Clarke, Mary Wallis, Vladimir A. Trifonov, Daria Graphodatskaya, Ferguson-Smith, Malcolm [0000-0001-9372-1381], and Apollo - University of Cambridge Repository
- Subjects
Male ,Chromosomes, Artificial, Bacterial ,animal structures ,Tachyglossidae ,Monotreme ,Polymerase Chain Reaction ,Chromosome Painting ,Birds ,biology.animal ,parasitic diseases ,Animals ,Humans ,Platypus ,X chromosome ,Sex Chromosomes ,biology ,Research ,Chromosome ,Karyotype ,Evolution of mammals ,biology.organism_classification ,body regions ,Testis determining factor ,Microscopy, Fluorescence ,Evolutionary biology ,Karyotyping ,Echidna ,Female - Abstract
A comparative study of the karyotype of the short-beaked echidna shows that monotremes appear to have a unique XY sex chromosome system that shares some homology with the avian Z., Background Sex-determining systems have evolved independently in vertebrates. Placental mammals and marsupials have an XY system, birds have a ZW system. Reptiles and amphibians have different systems, including temperature-dependent sex determination, and XY and ZW systems that differ in origin from birds and placental mammals. Monotremes diverged early in mammalian evolution, just after the mammalian clade diverged from the sauropsid clade. Our previous studies showed that male platypus has five X and five Y chromosomes, no SRY, and DMRT1 on an X chromosome. In order to investigate monotreme sex chromosome evolution, we performed a comparative study of platypus and echidna by chromosome painting and comparative gene mapping. Results Chromosome painting reveals a meiotic chain of nine sex chromosomes in the male echidna and establishes their order in the chain. Two of those differ from those in the platypus, three of the platypus sex chromosomes differ from those of the echidna and the order of several chromosomes is rearranged. Comparative gene mapping shows that, in addition to bird autosome regions, regions of bird Z chromosomes are homologous to regions in four platypus X chromosomes, that is, X1, X2, X3, X5, and in chromosome Y1. Conclusion Monotreme sex chromosomes are easiest to explain on the hypothesis that autosomes were added sequentially to the translocation chain, with the final additions after platypus and echidna divergence. Genome sequencing and contig anchoring show no homology yet between platypus and therian Xs; thus, monotremes have a unique XY sex chromosome system that shares some homology with the avian Z.
- Full Text
- View/download PDF
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