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4. Comprehensive genomic profiling of salivary gland carcinoma: Analysis of the Center for Cancer Genomics and Advanced Therapeutics database in Japan.

Author

Iwaki, Sho, Kawakita, Daisuke, Nagao, Toshitaka, Tada, Yuichiro, Honma, Yoshitaka, Ando, Mizuo, Matoba, Takuma, Minohara, Kiyoshi, Nakano, Satsuki, Murase, Takayuki, Iwasaki, Shinichi, and Inagaki, Hiroshi

Subjects
SALIVARY glands, DATABASES, ADENOID cystic carcinoma, SALIVARY gland cancer, PLEOMORPHIC adenoma, DRUG accessibility
Abstract

Comprehensive information on genetic alterations in salivary gland cancer (SGC) is limited. This study aimed to elucidate the genetic and clinical characteristics of patients with SGC using the Center for Cancer Genomics and Advanced Therapeutics (C‐CAT) database, a Japanese national genomic database. We analyzed data of 776 patients with SGC registered in the C‐CAT database between June 1, 2019, and June 30, 2023. Adenoid cystic carcinoma was the most common histologic type, followed by salivary duct carcinoma (SDC) and adenocarcinoma not otherwise specified. Genetic data of 681 patients receiving FoundationOne® CDx were analyzed. We identified specific features of the combination of TP53 and CDKN2A alterations among the histological types. Specific LYN amplification was mainly detected in carcinoma ex pleomorphic adenoma and myoepithelial carcinoma. For SDC, the frequency of ERBB2 and BRAF alterations were higher in cases with metastatic lesions than in those with primary lesions. Although 28.6% patients were offered recommended treatment options, only 6.8% received the recommended treatments. This study highlights the differences in genetic alterations among the histological types of SGC, with comprehensive genomic profiling tests revealing lower drug accessibility. These findings could contribute to the development of personalized treatment for patients with SGC. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Impact of salvage chemotherapy after immune checkpoint inhibitor for recurrent or metastatic head and neck cancer.

Author

Matoba, Takuma, Minohara, Kiyoshi, Kawakita, Daisuke, Sawabe, Michi, Takano, Gaku, Oguri, Keisuke, Murashima, Akihiro, Iwaki, Sho, Tsuge, Hiroshi, Imaizumi, Sae, Hojo, Wataru, Kondo, Ayano, Tsukamoto, Koji, and Iwasaki, Shinichi

Subjects
IMMUNE checkpoint inhibitors, CETUXIMAB, HEAD & neck cancer, CANCER chemotherapy, OVERALL survival, PROGRESSION-free survival
Abstract

Background: It is unclear witch regimen is optimal as salvage chemotherapy (SCT) after immune checkpoint inhibitor (ICI) monotherapy for recurrent or metastatic head and neck cancer (RM‐HNC). Methods: This study enrolled 109 patients. Overall survival (OS) and progression‐free survival 2 (PFS2) were compared between patients stratified by SCT regimen. Results: Of the 109 patients, 55 underwent SCT after the failure of ICI monotherapy. The OS of these 55 patients was longer than that of patients who did not undergo SCT. The OS and PFS2 were similar between patients treated with paclitaxel (PTX) and cetuximab (Cmab) combination and those treated with PTX monotherapy. The occurrence of irAEs did not impact PFS2 nor OS. Conclusions: SCT can improve the survival outcomes of patients with RM‐HNC. In addition to PTX and Cmab, PTX monotherapy is also considered an effective SCT regimen. SCT is effective regardless of the presence or absence of irAEs. [ABSTRACT FROM AUTHOR]

Published
2024
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6. The impact of clinicopathological factors on clinical outcomes in patients with salivary gland adenoid cystic carcinoma: a multi-institutional analysis in Japan

Author

Kawakita, Daisuke, Murase, Takayuki, Ueda, Kaori, Kano, Satoshi, Tada, Yuichiro, Tsukahara, Kiyoaki, Okami, Kenji, Onitsuka, Tetsuro, Fujimoto, Yasushi, Matoba, Takuma, Sakurai, Kazuo, Nagao, Toru, Hanai, Nobuhiro, Kawata, Ryo, Hato, Naohito, Nibu, Ken-ichi, Urano, Makoto, Taguchi, Ken-ichi, Nakaguro, Masato, Kusafuka, Kimihide, Yamamoto, Hidetaka, Nagao, Toshitaka, and Inagaki, Hiroshi

Published
2020
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7. Novel Prognostic Score for recurrent or metastatic head and neck cancer patients treated with Nivolumab

Author

Minohara, Kiyoshi, Matoba, Takuma, Kawakita, Daisuke, Takano, Gaku, Oguri, Keisuke, Murashima, Akihiro, Nakai, Kazuhiro, Iwaki, Sho, Hojo, Wataru, Matsumura, Ayano, Ozaki, Shinya, Ozawa, Taijiro, Harata, Ikuma, Tanaka, Nobukazu, Maseki, Shinichiro, Tsuge, Hiroshi, Imaizumi, Sae, Mitsuya, Shoji, Moribe, Kazuho, Esaki, Shinichi, and Iwasaki, Shinichi

Published
2021
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12. Indications for sentinel lymph node biopsy in node‐negative oral cancers

Author

Ozawa, Taijiro, primary, Oze, Isao, additional, Matsuzuka, Takashi, additional, Sasaki, Eiichi, additional, Yokoyama, Junkichi, additional, Sano, Yoshie, additional, Tomifuji, Masayuki, additional, Araki, Koji, additional, Kogashiwa, Yasunao, additional, Tateya, Ichiro, additional, Agena, Shinya, additional, Sakashita, Tomohiro, additional, Tsuzuki, Hidenori, additional, Terada, Hoshino, additional, Suzuki, Hidenori, additional, Nishikawa, Daisuke, additional, Beppu, Shintarou, additional, Matoba, Takuma, additional, Mukoyama, Nobuaki, additional, Oguri, Keisuke, additional, and Hasegawa, Yasuhisa, additional

Published
2023
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13. 集学的治療を行った鼻腔粘膜悪性黒色腫の臨床的検討

Author

Tsukamoto, Koji, primary, Kawakita, Daisuke, additional, Matoba, Takuma, additional, Takano, Gaku, additional, Oguri, Keisuke, additional, Murashima, Akihiro, additional, Minohara, Kiyoshi, additional, Sumiya, Shogo, additional, Nakai, Kazuyuki, additional, Iwaki, Sho, additional, Tsuge, Hiroshi, additional, Tanaka, Nobukazu, additional, Imaizumi, Sae, additional, Kondo, Ayano, additional, Hojo, Wataru, additional, Iwata, Hiromitsu, additional, Sanuki, Tetsuji, additional, and Iwasaki, Shinichi, additional

Published
2023
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14. Mature dendritic cells enriched in regulatory molecules may control regulatory T cells and the prognosis of head and neck cancer

Author

Minohara, Kiyoshi, primary, Imai, Masaki, additional, Matoba, Takuma, additional, Wing, James Badger, additional, Shime, Hiroaki, additional, Odanaka, Mizuyu, additional, Uraki, Ryuta, additional, Kawakita, Daisuke, additional, Toyama, Tatsuya, additional, Takahashi, Satoru, additional, Morita, Akimichi, additional, Murakami, Shingo, additional, Ohkura, Naganari, additional, Sakaguchi, Shimon, additional, Iwasaki, Shinichi, additional, and Yamazaki, Sayuri, additional

Published
2023
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15. 喉頭摘出術を併施した頸部食道癌例

Author

Murashima, Akihiro, primary, Kawakita, Daisuke, additional, Matoba, Takuma, additional, Takano, Gaku, additional, Oguri, Keisuke, additional, Minohara, Kiyoshi, additional, Iwaki, Sho, additional, Tsuge, Hiroshi, additional, Imaizumi, Sae, additional, Kondo, Ayano, additional, Tsukamoto, Koji, additional, Tanaka, Tatsuya, additional, Ogawa, Ryo, additional, and Iwasaki, Shinichi, additional

Published
2023
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18. Two cases of chronic GVHD-related tongue cancer

Author

Kondo-Matsumura, Ayano, primary, Kawakita, Daisuke, additional, Matoba, Takuma, additional, Takano, Gaku, additional, Oguri, Keisuke, additional, Murashima, Akihiro, additional, Minohara, Kiyoshi, additional, Nakai, Kazuyuki, additional, Iwaki, Sho, additional, Tsuge, Hiroshi, additional, Tsukamoto, Koji, additional, Hojo, Wataru, additional, and Iwasaki, Shinichi, additional

Published
2022
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19. Clinical analysis of lenvatinib therapy for unresectable thyroid cancer at Nagoya City University Hospital and related facilities

Author

Takano, Gaku, primary, Kawakita, Daisuke, additional, Matoba, Takuma, additional, Oguri, Keisuke, additional, Murashima, Akihiro, additional, Minohara, Kiyoshi, additional, Tsuge, Hiroshi, additional, Matsumura, Ayano, additional, Hojo, Wataru, additional, Tsukamoto, Koji, additional, Harata, Ikuma, additional, Maseki, Shinichiro, additional, Ozawa, Taijiro, additional, Mitsuya, Shoji, additional, Moribe, Kazuho, additional, and Iwasaki, Shinichi, additional

Published
2022
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21. Long-term efficacy of weekly paclitaxel therapy in unresectable primary squamous cell carcinoma of the thyroid

Author

Iwaki, Sho, primary, Kawakita, Daisuke, additional, Sawabe, Michi, additional, Matoba, Takuma, additional, Takano, Gaku, additional, Oguri, Keisuke, additional, Murashima, Akihiro, additional, Minohara, Kiyoshi, additional, Tanaka, Nobukazu, additional, Tsuge, Hiroshi, additional, Imaizumi, Sae, additional, Matsumura, Ayano, additional, Masaki, Ayako, additional, Murase, Takayuki, additional, Ogawa, Masaki, additional, and Iwasaki, Shinichi, additional

Published
2021
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22. Novel Prognostic Score for Recurrent or Metastatic Head and Neck Cancer Patients treated with Nivolumab: Japanese Multi-Institutional Cohort Study

Author

Minohara, Kiyoshi, primary, Matoba, Takuma, additional, Kawakita, Daisuke, additional, Takano, Gaku, additional, Oguri, Keisuke, additional, Murashima, Akihiro, additional, Nakai, Kazuhiro, additional, Iwaki, Sho, additional, Hojo, Ayumu, additional, Matsumura, Ayano, additional, Ozaki, Shinya, additional, Ozawa, Taijiro, additional, Harata, Ikuma, additional, Tanaka, Nobukazu, additional, Maseki, Shinichiro, additional, Tsuge, Hiroshi, additional, Imaizumi, Sae, additional, Mitsuya, Shoji, additional, Moribe, Kazuho, additional, Esaki, Shinichi, additional, and Iwasaki, Shinichi, additional

Published
2021
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24. Evaluation of the modified Pittsburgh classification for predicting the disease‐free survival outcome of squamous cell carcinoma of the external auditory canal

Author

Nabuurs, Cindy H., primary, Kievit, Wietske, additional, Labbé, Nilou, additional, Leemans, C. René, additional, Smit, Conrad F. G. M., additional, Brekel, Michiel W. M., additional, Pauw, Robert J., additional, Laan, Bernard F. A. M., additional, Jansen, Jeroen C., additional, Lacko, Martin, additional, Braunius, Weibel W., additional, Morita, Shinya, additional, Wierzbicka, Małgorzata, additional, Matoba, Takuma, additional, Hanai, Nobuhiro, additional, Takes, Robert P., additional, and Kunst, Henricus P. M., additional

Published
2020
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25. Proenkephalin + regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function

Author

Shime, Hiroaki, primary, Odanaka, Mizuyu, additional, Tsuiji, Makoto, additional, Matoba, Takuma, additional, Imai, Masaki, additional, Yasumizu, Yoshiaki, additional, Uraki, Ryuta, additional, Minohara, Kiyoshi, additional, Watanabe, Maiko, additional, Bonito, Anthony John, additional, Fukuyama, Hidehiro, additional, Ohkura, Naganari, additional, Sakaguchi, Shimon, additional, Morita, Akimichi, additional, and Yamazaki, Sayuri, additional

Published
2020
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30. Third Epidemiological Analysis of Nasopharyngeal Carcinoma in the Central Region of Japan from 2006 to 2015

Author

Kanno, Masafumi, primary, Narita, Norihiko, additional, Fujimoto, Yasushi, additional, Wakisaka, Naohiro, additional, Yoshizaki, Tomokazu, additional, Kodaira, Takeshi, additional, Makita, Chiyoko, additional, Sato, Yuichiro, additional, Yamazaki, Keisuke, additional, Wakaoka, Takanori, additional, Shimode, Yuzo, additional, Tsuji, Hiroyuki, additional, Kito, Ryosuke, additional, Ishinaga, Hajime, additional, Hosokawa, Seiji, additional, Takakura, Hiromasa, additional, Nishimura, Kunihiro, additional, Matoba, Takuma, additional, and Fujieda, Shigeharu, additional

Published
2019
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35. Regulatory T cells expressing abundant CTLA‐4 on the cell surface with a proliferative gene profile are key features of human head and neck cancer.

Author

Matoba, Takuma, Imai, Masaki, Ohkura, Naganari, Kawakita, Daisuke, Ijichi, Kei, Toyama, Tatsuya, Morita, Akimichi, Murakami, Shingo, Sakaguchi, Shimon, and Yamazaki, Sayuri

Abstract

FOXP3+ regulatory T (Treg) cells suppress anti‐tumor immunity. The suppression of Treg cells is regulated by cytotoxic T‐lymphocyte‐associated antigen‐4 (CTLA‐4), whose expression on the cell surface is tightly regulated. Here we found that Treg cells expressing abundant CTLA‐4 on the cell surface (surface‐CTLA‐4+ Treg) were expanded in human head and neck cancer tissues. RNA sequencing of surface‐CTLA‐4+ and surface‐CTLA‐4− Treg cells infiltrating human head and neck cancer tissues revealed that surface‐CTLA‐4+ Treg cells have a previously undescribed gene expression profile correlating to cell cycle, cell proliferation, and DNA replication. Moreover, surface‐CTLA‐4+ Treg cells were PD‐1+, actively proliferated and associated with CD45RA− FOXP3high Treg cells with strong suppressive function. Thus, surface‐CTLA‐4+ Treg cells with a proliferative gene expression signature and phenotype are key features of head and neck cancer. Targeting surface‐CTLA‐4+ Treg cells might be new strategies to evoke effective immune responses to head and neck cancer. What's new? Regulatory T (Treg) cells have been shown to suppress anti‐tumor immunity. CTLA‐4 is key in controlling Treg function, but its importance in head and neck cancer remains unclear. Here, the authors found that Treg cells with abundant CTLA‐4 on the cell surface (surface‐CTLA‐4+ Treg) were expanded in human head and neck cancer. This is surprising because most CTLA‐4 is generally expressed intracellularly. Surface‐CTLA‐4+ Treg cells in human head and neck cancer highly expressed previously‐undescribed genes correlated to cell cycle, cell proliferation, and DNA replication. Targeting surface‐CTLA‐4+ Treg cells might lead to new strategies for eliciting anti‐tumor immunity in human cancer. [ABSTRACT FROM AUTHOR]

Published
2019
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37. Long-term efficacy of weekly paclitaxel therapy in unresectable primary squamous cell carcinoma of the thyroid.

Author

Iwaki, Sho, Kawakita, Daisuke, Sawabe, Michi, Matoba, Takuma, Takano, Gaku, Oguri, Keisuke, Murashima, Akihiro, Minohara, Kiyoshi, Tanaka, Nobukazu, Tsuge, Hiroshi, Imaizumi, Sae, Matsumura, Ayano, Masaki, Ayako, Murase, Takayuki, Ogawa, Masaki, and Iwasaki, Shinichi

Subjects
*SQUAMOUS cell carcinoma, *THYROID cancer, *PACLITAXEL, *ANAPLASTIC thyroid cancer, *CAROTID artery, *PROGNOSIS
Abstract

Primary squamous cell carcinoma of the thyroid (PSCCT) is a rare disease with a poor prognosis. Because of its rarity, there is no established therapeutic regimen in unresectable cases. We report a case of PSCCT treated with weekly paclitaxel (wPTX) for more than 2 years. A 59-year-old woman presented to our hospital with a progressively enlarging neck mass. CT and MRI scans showed a tumor arising from the right lobe of the thyroid, invading the esophagus and trachea, as well as partially surrounding and invading the right common carotid artery. It was deemed unresectable. Biopsy revealed poorly differentiated squamous cell carcinoma. wPTX therapy was initiated. The patient achieved a partial response and is still undergoing treatment 28 months later. Adverse events included grade 3 neutropenia and grade 2 peripheral sensory neuropathy, which were manageable. Long-term wPTX therapy has been effective in this case of unresectable PSCCT. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Reply to Slominski et al.: UVB irradiation induces proenkephalin + regulatory T cells with a wound-healing function.

Author

Shime H, Odanaka M, Tsuiji M, Matoba T, Imai M, Yasumizu Y, Uraki R, Minohara K, Watanabe M, Bonito AJ, Fukuyama H, Ohkura N, Sakaguchi S, Morita A, and Yamazaki S

Subjects
Enkephalins, Homeostasis, Protein Precursors, Ultraviolet Rays, Skin, T-Lymphocytes, Regulatory
Abstract

Competing Interests: The authors declare no competing interest.

Published
2021
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39. Diagnostic Performance of Whole-Body Diffusion-Weighted Imaging Compared to PET-CT Plus Brain MRI in Staging Clinically Resectable Lung Cancer.

Author

Usuda K, Sagawa M, Maeda S, Motono N, Tanaka M, Machida Y, Matoba TM, Watanabe N, Tonami H, Ueda Y, and Uramoto H

Subjects
Adenocarcinoma diagnosis, Adenocarcinoma diagnostic imaging, Adenocarcinoma surgery, Adult, Aged, Aged, 80 and over, Carcinoma, Small Cell diagnosis, Carcinoma, Small Cell diagnostic imaging, Carcinoma, Small Cell surgery, Carcinoma, Squamous Cell diagnosis, Carcinoma, Squamous Cell diagnostic imaging, Carcinoma, Squamous Cell surgery, Female, Follow-Up Studies, Humans, Lung Neoplasms diagnostic imaging, Lung Neoplasms surgery, Male, Middle Aged, Prognosis, Diffusion Magnetic Resonance Imaging methods, Lung Neoplasms diagnosis, Multimodal Imaging methods, Neoplasm Staging standards, Positron Emission Tomography Computed Tomography methods, Whole Body Imaging methods
Abstract

Background: Precise staging of lung cancer is usually evaluated by PET-CT and brain MRI. Recently, however, whole-body diffusion-weighted magnetic resonance imaging (WB-DWI) has be applied. The aim of this study is to determine whether the diagnostic performance of lung cancer staging by WB-DWI is superior to that of PET-CT+brain MRI., Materials and Methods: PET-CT + brain MRI and WB-DWI were used for lung cancer staging before surgery with 59 adenocarcinomas, 16 squamous cell carcinomas and 6 other carcinomas., Results: PET-CT + brain MRI correctly identified the pathologic N staging in 67 patients (82.7%), with overstaging in 5 (6.2%) and understaging in 9 (11.1%), giving a staging accuracy of 0.827. WB-DWI correctly identified the pathologic N staging in 72 patients (88.9%), with overstaging in 1 (1.2%) and understaging in 8 patients (9.9%), giving a staging accuracy of 0.889. There were no significant differences in accuracies. PET-CT + brain MRI correctly identified the pathologic stages in 56 patients (69.1%), with overstaging in 7 (8.6%) and understaging in 18 (22.2%), giving a staging accuracy of 0.691. WB-DWI correctly identified the pathologic stages in 61 patients (75.3%), with overstaging in 4 (4.9%) and understagings in16(19.7%), giving a staging accuracy of 0.753. There were no significant difference in accuracies., Conclusions: Diagnostic efficacy of WB-DWI for lung cancer staging is equivalent to that of PET-CT + brain MRI.

Published
2016

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