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Surface acoustic waves (SAWs) are a versatile tool for realizing coherent quantum interfaces between various solid-state qubits spanning microwave to optical frequencies. Through strain, electric, or magnetic fields associated with acoustic waves, qubit states can be controlled and measured with exquisite precision for applications in quantum information processing, memory, transduction, and sensing. In this review, we discuss progress toward quantum control using surface acoustic waves coupled to optically active artificial atoms, including semiconductor quantum dots (QDs), optically addressable solid-state spins, and quantum emitters in van der Waals materials. We outline the device, material, and theoretical considerations for realizing interactions with surface acoustic waves in the quantum regime, summarize the state of the art in coupling surface acoustic waves to artificial atoms, and provide insight into the current trends and trajectory of the field.

In this study, we evaluate hydrogels based on oxidized hyaluronic acid, cross-linked with adipic acid dihydrazide, for their suitability as bioinks for 3D bioprinting. Aldehyde containing hyaluronic acid (AHA) is synthesized and cross-linked via Schiff Base chemistry with bifunctional adipic acid dihydrazide (ADH) to form a mechanically stable hydrogel with good printability. Mechanical and rheological properties of the printed and casted hydrogels are tunable depending on the concentrations of AHA and ADH cross-linkers.

Abstract Microfluidics and droplet-based assays are the basis for numerous high-throughput experiments, including bio-inspired microreactors and selection platforms for directed evolution. While elaborate techniques are available for the production of picoliter-sized droplets, there is an increasing demand for subsequent manipulation and control of the droplet interior. Here, we report on a straightforward method to rapidly adjust the size of single to several hundred double-emulsion droplets in a microfluidic sieve by varying the carrier fluid’s salt concentration. We show that the concomitant concentration changes in the droplet interior can drive a reversible demixing transition in a biomimetic binary fluid. As another application, we show that growing and shrinking of trapped droplets can be utilized to achieve a reversible dissociation of double-stranded DNA into single strands, i.e. cycles of reversible DNA hybridization, similar to PCR cycles, can be achieved by reversibly changing the droplet size at constant temperature. Altogether, our approach shows how a simple and temporally tunable manipulation of the size and the chemistry in prefabricated droplets can be achieved by an external control parameter.

Abstract Background Device-related bacterial infections account for a large proportion of hospital-acquired infections. The ability of bacteria to form a biofilm as a protective shield usually makes treatment impossible without removal of the implant. Topographic surfaces have attracted considerable attention in studies seeking antibacterial properties without the need for additional antimicrobial substances. As there are still no valid rules for the design of antibacterial microstructured surfaces, a fast, reproducible production technique with good resolution is required to produce test surfaces and to examine their effectiveness with regard to their antibacterial properties. Methods In this work various surfaces, flat and with microcylinders in different dimensions (flat, 1, 3 and 9 μm) with a surface area of 7 × 7 mm were fabricated with a nanoprinter using two-photon lithography and evaluated for their antibiofilm effect. The microstructured surfaces were cultured for 24 h with different strains of Pseudomonas aeruginosa and Staphylococcus aureus to study bacterial attachment to the patterned surfaces. In addition, surface wettability was measured by a static contact angle measurement. Results Contact angles increased with cylinder size and thus hydrophobicity. Despite the difference in wettability, Staphylococcus aureus was not affected by the microstructures, while for Pseudomonas aeruginosa the bacterial load increased with the size of the cylinders, and compared to a flat surface, a reduction in bacteria was observed for one strain on the smallest cylinders. Conclusions Two-photon lithography allowed rapid and flexible production of microcylinders of different sizes, which affected surface wettability and bacterial load, however, depending on bacterial type and strain.

Abstract In this work we present a complete three-loop renormalisation of an abelian chiral gauge theory within the Breitenlohner-Maison/’t Hooft-Veltman (BMHV) scheme of dimensional regularisation (DReg). In this scheme the γ 5-matrix appearing in gauge interactions is a non-anticommuting object, leading to a breaking of gauge and BRST invariance. Employing an efficient method based on the quantum action principle, we obtain the complete three-loop counterterm action which serves both to render the theory finite and to restore gauge and BRST invariance. The UV singular counterterms involve not only higher order ϵ-poles but also new counterterm structures emerging at the three-loop level for the first time; the finite symmetry-restoring counterterms are restricted to the same structures as at lower loop orders, just with different coefficients, aligning with our expectations. Both the singular and the finite counterterms include structures which cannot be obtained by the standard multiplicative renormalisation. Our results demonstrate that a rigorous treatment of chiral gauge theories with γ 5 defined in the BMHV scheme at the multi-loop level is possible and that the obtained counterterm action is suitable for computer implementations, allowing automated calculations without ambiguities caused by γ 5.

Abstract In recent years, theoretical and phenomenological studies with effective field theories have become a trending and prolific line of research in the field of high-energy physics. In order to discuss present and future prospects concerning automated tools in this field, the SMEFT-Tools 2022 workshop was held at the University of Zurich from 14th–16th September 2022. The current document collects and summarizes the content of this workshop.

Abstract Drought has a significant impact on plant–insect interactions by altering plant survival, growth, leaf quality, and defense traits. Tropical plants are particularly vulnerable to water depression because of shallow root depth. In the context of climate change, drought events are expected to increase in frequency and intensity; however, their impact on tropical ecosystems remains poorly known. Insect herbivores represent the largest feeding guild of arthropods, and they devour four to five times more plant material than vertebrates do. Understanding how drought affects plant traits and leaf palatability in a keystone and ecologically diverse plant genus, such as Ficus (Moraceae), is crucial for predicting how climate change might alter tropical plant–insect interactions. We examined the impact of drought intensity and duration on the leaf nutritional quality, defensive traits, and herbivory damage by caterpillars in three tropical and one Mediterranean Ficus species in a greenhouse. We also conducted food choice trials with generalist caterpillars to evaluate the impact of drought on herbivores. Drought intensity and duration had no direct effect on leaf palatability across the Ficus species. However, drought indirectly affected leaf palatability via drought‐induced leaf traits in a species‐specific manner. Drought intensity and duration decreased leaf water content, resulting in decreased leaf palatability in F. benjamina and F. lyrata. Leaf defensive traits such as flavonoid concentration were affected by drought intensity and decreased leaf palatability in F. carica. Drought influenced the leaf traits of F. elastica, but none of them affected leaf palatability. Overall, this study establishes the link between drought and insect feeding on plants via leaf traits. The species‐specific responses to drought highlight the significance of climate‐related plant life histories in relation to climate change, underscoring the need for further investigations.

The sheet metal forming of magnesium is challenging due to the material’s complex springback behaviour, which is due to the tension/compression yield mismatch. In this study, three different AZ31 grain sizes are produced by a special heat treatment, while maintaining the material strength in uniaxial tension at a similar level. Pure, V-die and channel bending tests are combined with roll forming to compare bending scenarios with and without tension applied transverse and parallel to the bending axis. This is complemented with electron backscatter diffraction to measure the twinning type and twinning area fraction (TAF) in the tension and compression bending zones. Our study shows that, like conventional steel, when bending magnesium, springback reduces with the increasing level of the outer fibre bending strain, i.e., when the bend radius is decreased and the TAF increased. It is further shown that when tension is applied, the TAF increases. However, while in some forming cases, the increase in TAF leads to a clear reduction in springback, in other forming cases the effect of the TAF on springback is less pronounced. Overall, this study provides clear evidence that the twinning behaviour in bending magnesium is influenced by the bend deformation mode and that this influences the springback behaviour.

Abstract Isolated active sites have great potential to be highly efficient and stable in heterogeneous catalysis, while enabling low costs due to the low transition metal content. Herein, we present results on the synthesis, first catalytic trials, and characterization of the Ga9Rh2 phase and the hitherto not-studied Ga3Rh phase. We used XRD and TEM for structural characterization, and with XPS, EDX we accessed the chemical composition and electronic structure of the intermetallic compounds. In combination with catalytic tests of these phases in the challenging propane dehydrogenation and by DFT calculations, we obtain a comprehensive picture of these novel catalyst materials. Their specific crystallographic structure leads to isolated Rhodium sites, which is proposed to be the decisive factor for the catalytic properties of the systems.

Anomalous-diffusion identifies the departure of diffusive dynamics from the traditional Brownian-motion and is a signature feature of a large number of complex soft-matter and biological systems. This article reports an analysis of an easy to implement method to decide on the type of an apparent anomaly, even in the presence of localisation errors.

Hybrid quantum technologies synergistically combine different types of systems with complementary strengths. Here, the authors show monolithic integration and control of quantum dots and the emitted single photons in a surface acoustic wave-driven GaAs integrated quantum photonic circuit.

Air-coupled ultrasonic testing is an established alternative to conventional ultrasonic methods for testing of light-weight components in aerospace and automotive industry. Compared to direct coupled contact technique or immersion technique it is less invasive, so that it offers numerous financial incentives. While phased arrays are already an industrial standard in fluid-coupled mechanized ultrasonic testing, air-coupled testing is usually performed using two single-element probes and a transmission technique. Therefore, advantages of phased arrays such as active focussing and manipulation of the incidence angle are rarely used with air-coupled testing. This paper presents a newly developed air-coupled phased array device with the emphasis on the characterization of the probes. The device consists of a linear array probe, a transmitter unit and a receiver unit. The main novelty is that the array probe is based on high-voltage excitation of charged cellular polypropylene. Charged cellular polymers are referred to as ferroelectrets or as piezoelectrets. They exhibit an extremely low stiffness and acoustic impedance, so that a matching layer is not necessary. Extremely low mechanical cross-coupling enables independent excitation of the elements of the array. The development of the phased array probes is supported by computations of the sound field using point source synthesis. The main intended applications are transmission with focussing, transmission with an electronic sweep and testing with air-coupled guided waves by using beam steering, applied to carbon-fibre-reinforced plates and similar materials. Air-coupled guided waves enable testing of objects with one-sided access. This work was funded from the “Technologietransfer-Programm Leichtbau” by the German Federal Ministry for Economic Affairs and Climate Action, project 03LB1001A.

Standard non-invasive acoustic non-destructive testing (NDT) methods like testing in contact or using immersion tank arrangements are limited since the probes need to be in direct contact with the test piece or using a fluid as coupling media. Air-coupled ultrasonic testing avoids these limitations and enables new testing methods. Two up-and-coming transducer technologies are recognized as promising: transducers using ferroelectrets and transmitters based on the thermoacoustic principle. Thermoacoustic radiators based on thin-film technology offer a resonant-free generation of ultrasound. The resonance-free operation enables the wideband generation of acoustics waves and promises advantages for existing NDT methods. Using specially shaped substrates and electrodes enables the fabrication of planar and focused thermoacoustic radiators. This contribution presents the latest results of our ongoing research regarding thermoacoustic radiators, which is the thermoacoustic phased-array. Phased-array transducers offer the on-the-fly change of the steering angle and the position of the focal point without moving or modifying the transducer itself. Combining both technologies, thermoacoustic emitter and the phasedarray principle broaden the spectrum of classical NDT applications and modern approaches like the excitation of guided waves or structural health monitoring. In detail, we modelled the sound field of a self-fabricated thermoacoustic phased-array radiator, characterised the emitter elementwise and tested several application scenarios (e.g., transmission, beam steering, focusing and the excitation of guided waves).

Background: Lymph node metastases (LNM) are rare in early-stage endometrial cancer, but a diagnostic systematic lymphadenectomy (LNE) is often performed to achieve reliable N-staging. Therefore, this prospective study aimed to evaluate the benefit of [18F]-Fluorodeoxyglucose (FDG) PET/MRI complementary to SPECT/CT guided sentinel lymphonodectomy (SLNE) for a less invasive N-staging Methods: 79 patients underwent a whole-body FDG-PET/MRI, SLN mapping with 99mTc-Nanocolloid SPECT/CT and indocyanine green (ICG) fluoroscopy followed by LNE which served as ground truth. Results: FDG-PET/MRI was highly specific in N-staging (97.2%) but revealed limited sensitivity (66.7%) due to missed micrometastases. In contrast, bilateral SLN mapping failed more often in patients with macrometastases. The combination of SLN mapping and FDG-PET/MRI increased the sensitivity from 66.7% to 77.8%. Additional SLN labeling with dye (ICG) revealed a complete SLN mapping in 80% (8/10) of patients with failed or incomplete SLN detection in SPECT/CT, reducing the need for diagnostic systematic LNE up to 87%. FDG-PET/MRI detected para-aortic LNM in three out of four cases and a liver metastasis. Conclusions: The combination of FDG-PET/MRI and SLNE can reduce the need for diagnostic systematic LNE by up to 87%. PET/MRI complements the SLN technique particularly in the detection of para-aortic LNM and occasional distant metastases.

Allometric relations between two observables are a widespread phenomenon in biology. The volume of nuclei, for example, has frequently been reported to scale linearly with cell volume, V_{N}∼V_{C}, but conflicting, sublinear power-law correlations have also been found. Given that nuclei are vital organelles that harbor and maintain the DNA of cells, an understanding of allometric nuclear volumes that ultimately define the concentration and accessibility of chromatin is of great interest. Using the model organism Caenorhabditis elegans, we show here that the allometry of nuclei is a dynamically adapting phenomenon; i.e., we find V_{N}∼V_{C}^{α} with a time-dependent scaling exponent α (“dynamic allometry”). This finding is due to relaxation growth of nuclear volumes at a rate that scales with cell size. If cell division stops the relaxation of nuclei in a premature stage, α

Abstract Background Functional genomics uses unbiased systematic genome-wide gene disruption or analyzes natural variations such as gene expression profiles of different tissues from multicellular organisms to link gene functions to particular phenotypes. Functional genomics approaches are of particular importance to identify large sets of genes that are specifically important for a particular biological process beyond known candidate genes, or when the process has not been studied with genetic methods before. Results Here, we present a large set of genes whose disruption interferes with the function of the odoriferous defensive stink glands of the red flour beetle Tribolium castaneum. This gene set is the result of a large-scale systematic phenotypic screen using RNA interference applied in a genome-wide forward genetics manner. In this first-pass screen, 130 genes were identified, of which 69 genes could be confirmed to cause phenotypic changes in the glands upon knock-down, which vary from necrotic tissue and irregular reservoir size to irregular color or separation of the secreted gland compounds. Gene ontology analysis revealed that many of those genes are encoding enzymes (peptidases and cytochromes P450) as well as proteins involved in membrane trafficking with an enrichment in lysosome and mineral absorption pathways. The knock-down of 13 genes caused specifically a strong reduction of para-benzoquinones in the gland reservoirs, suggesting a specific function in the synthesis of these toxic compounds. Only 14 of the 69 confirmed gland genes are differentially overexpressed in stink gland tissue and thus could have been detected in a transcriptome-based analysis. However, only one out of eight genes identified by a transcriptomics approach known to cause phenotypic changes of the glands upon knock-down was recognized by this phenotypic screen, indicating the limitation of such a non-redundant first-pass screen. Conclusion Our results indicate the importance of combining diverse and independent methodologies to identify genes necessary for the function of a certain biological tissue, as the different approaches do not deliver redundant results but rather complement each other. The presented phenotypic screen together with a transcriptomics approach are now providing a set of close to hundred genes important for odoriferous defensive stink gland physiology in beetles.

ObjectivePatients with impaired kidney function are at elevated risk for nephrotoxicity and hematotoxicity from peptide receptor radionuclide therapy (PPRT) for advanced neuroendocrine tumors. Somatostatin receptor (SSR)-PET/CT imaging is the method of choice to identify sufficient SSR expression as a prerequisite for PRRT. Therefore, our study aimed to explore whether split renal function could be evaluated using imaging data from routine SSR-PET/CT prior to PRRT.MethodsIn total, 25 consecutive patients who underwent SSR-PET/CT (Siemens Biograph mCT®) before PRRT between June 2019 and December 2020 were enrolled in this retrospective study. PET acquisition in the caudocranial direction started at 20 ± 0.5 min after an i.v. injection of 173 ± 20 MBq [68Ga]Ga-ha DOTATATE, and the kidneys were scanned at 32 ± 0.5 min p.i. The renal parenchyma was segmented semi-automatically using an SUV-based isocontour (SUV between 5 and 15). Multiple parameters including SUVmean of renal parenchyma and blood pool, as well as parenchyma volume, were extracted, and accumulation index (ACI: renal parenchyma volume/SUVmean) and total kidney accumulation (TKA: SUVmean x renal parenchyma volume) were calculated. All data were correlated with the reference standard tubular extraction rate (TER-MAG) from [99mTc]Tc-MAG3 scintigraphy and glomerular filtration rate (GFRCDK − EPI).ResultsSUVmean of the parenchymal tracer retention showed a negative correlation with TERMAG (r: −0.519, p < 0.001) and GFRCDK − EPI (r: −0.555, p < 0.001) at 32 min p.i. The herein-introduced ACI revealed a significant correlation (p < 0.05) with the total tubular function (r: 0.482), glomerular renal function (r: 0.461), split renal function (r: 0.916), and absolute single-sided renal function (r: 0.549). The mean difference between the split renal function determined by renal scintigraphy and ACI was 1.8 ± 4.2 % points.ConclusionThis pilot study indicates that static [68Ga]Ga-ha DOTATATE PET-scans at 32 min p.i. may be used to estimate both split renal function and absolute renal function using the herein proposed “Accumulation Index” (ACI).

Abstract The objective of this study is to examine the association between neighborhood socioeconomic status (nSES) and baseline allostatic load (AL) and clinical trial endpoints in patients enrolled in the E1A11 therapeutic trial in multiple myeloma (MM). Study endpoints were symptom burden (pain, fatigue, and bother) at baseline and 5.5 months, non-completion of induction therapy, overall survival (OS) and progression-free survival (PFS). Multivariable logistic and Cox regression examined associations between nSES, AL and patient outcomes. A 1-unit increase in baseline AL was associated with greater odds of high fatigue at baseline (adjusted OR [95% CI] = 1.21 [1.08–1.36]) and a worse OS (adjusted hazard ratio, [95% CI] = 1.21 [1.06–1.37]). High nSES was associated with worse baseline bother (middle OR = 4.22 [1.11–16.09] and high 4.49 [1.16–17.43]) compared to low nSES. There was no association between AL or nSES and symptom burden at 5.5 months, non-completion of induction therapy or PFS. Additionally, there was no association between nSES and OS. AL may have utility as a predictive marker for OS among patients with MM and may allow individualization of treatment. Future studies should standardize and validate AL patients with MM.

Abstract Background Most of the known genes required for developmental processes have been identified by genetic screens in a few well-studied model organisms, which have been considered representative of related species, and informative—to some degree—for human biology. The fruit fly Drosophila melanogaster is a prime model for insect genetics, and while conservation of many gene functions has been observed among bilaterian animals, a plethora of data show evolutionary divergence of gene function among more closely-related groups, such as within the insects. A quantification of conservation versus divergence of gene functions has been missing, without which it is unclear how representative data from model systems actually are. Results Here, we systematically compare the gene sets required for a number of homologous but divergent developmental processes between fly and beetle in order to quantify the difference of the gene sets. To that end, we expanded our RNAi screen in the red flour beetle Tribolium castaneum to cover more than half of the protein-coding genes. Then we compared the gene sets required for four different developmental processes between beetle and fly. We found that around 50% of the gene functions were identified in the screens of both species while for the rest, phenotypes were revealed only in fly (~ 10%) or beetle (~ 40%) reflecting both technical and biological differences. Accordingly, we were able to annotate novel developmental GO terms for 96 genes studied in this work. With this work, we publish the final dataset for the pupal injection screen of the iBeetle screen reaching a coverage of 87% (13,020 genes). Conclusions We conclude that the gene sets required for a homologous process diverge more than widely believed. Hence, the insights gained in flies may be less representative for insects or protostomes than previously thought, and work in complementary model systems is required to gain a comprehensive picture. The RNAi screening resources developed in this project, the expanding transgenic toolkit, and our large-scale functional data make T. castaneum an excellent model system in that endeavor.

In the near future, humans will increasingly be required to offload tasks to artificial systems to facilitate daily as well as professional activities. Yet, research has shown that humans are often averse to offloading tasks to algorithms (so-called "algorithmic aversion"). In the present study, we asked whether this aversion is also present when humans act under high cognitive load. Participants performed an attentionally demanding task (a multiple object tracking (MOT) task), which required them to track a subset of moving targets among distractors on a computer screen. Participants first performed the MOT task alone (Solo condition) and were then given the option to offload an unlimited number of targets to a computer partner (Joint condition). We found that participants significantly offloaded some (but not all) targets to the computer partner, thereby improving their individual tracking accuracy (Experiment 1). A similar tendency for offloading was observed when participants were informed beforehand that the computer partner's tracking accuracy was flawless (Experiment 2). The present findings show that humans are willing to (partially) offload task demands to an algorithm to reduce their own cognitive load. We suggest that the cognitive load of a task is an important factor to consider when evaluating human tendencies for offloading cognition onto artificial systems.

Kompetenzentwicklung in der beruflichen Aus- und Weiterbildung beinhaltet den Erwerb von Wissen, Fertigkeiten und Einstellungen, häufig mit einem Schwerpunkt auf psychomotorischer Koordination. Der Kompetenzerwerb in der Ausbildung zum Fahrzeuglackierer bzw. zur Fahrzeuglackiererin wird durch soziale, wirtschaftliche und ökologische Faktoren behindert. Um diese Hürden zu überwinden, entwickelt das Forschungsprojekt HandLeVR (Handlungsorientiertes Lernen in der VR-Lackierwerkstatt) ein Virtual-Reality-Training auf der Grundlage des empirisch validierten 4C/ID-Modells. Der Artikel stellt das Vorgehen und die Resultate des Projekts vor und präsentiert Ergebnisse einer ersten Evaluierungsstudie (z. B. zu Akzeptanz und Präsenzerleben).

Secondary infections in coronavirus disease 2019 (COVID-19) patients are difficult to distinguish from inflammation associated with COVID-19 and/or extracorporeal membrane oxygenation (ECMO). Therefore, highly specific and sensitive biomarkers are needed to identify patients in whom antimicrobial therapy can be safely withheld. In this prospective monocentric study, 66 COVID-19 patients admitted to the intensive care unit (ICU) for ECMO evaluation were included. A total of 46 (70%) patients with secondary infections were identified by using broad microbiological and virological panels and standardized diagnostic criteria. Various laboratory parameters including C-reactive protein (CRP), interleukin (IL)-6, procalcitonin (PCT), and IL-10 were determined at time of study inclusion. The best test performance for differentiating bacterial/fungal secondary infections and COVID-19 and/or ECMO associated inflammation was achieved by IL-10 (ROC-AUC 0.84) and a multivariant step-wise regression model including CRP, IL-6, PCT, and IL-10 (ROC-AUC 0.93). Data obtained in the present study highlights the use of IL-10 to differentiate secondary bacterial/fungal infections from COVID-19 and/or ECMO associated inflammation in severely ill COVID-19 patients.

Purpose: The consideration of radiation exposure is becoming more important in metastatic melanoma due to improved prognoses. The aim of this prospective study was to investigate the diagnostic performance of whole-body (WB) magnetic resonance imaging (MRI) in comparison to computed tomography (CT) with 18F-FDG positron emission tomography (PET)/CT and 18F-PET/MRI together with a follow-up as the reference standard. Methods: Between April 2014 and April 2018, a total of 57 patients (25 females, mean age of 64 ± 12 years) underwent WB-PET/CT and WB-PET/MRI on the same day. The CT and MRI scans were independently evaluated by two radiologists who were blinded to the patients’ information. The reference standard was evaluated by two nuclear medicine specialists. The findings were categorized into different regions: lymph nodes/soft tissue (I), lungs (II), abdomen/pelvis (III), and bone (IV). A comparative analysis was conducted for all the documented findings. Inter-reader reliability was assessed using Bland–Altman procedures, and McNemar’s test was utilized to determine the differences between the readers and the methods. Results: Out of the 57 patients, 50 were diagnosed with metastases in two or more regions, with the majority being found in region I. The accuracies of CT and MRI did not show significant differences, except in region II where CT detected more metastases compared to MRI (0.90 vs. 0.68, p = 0.008). On the other hand, MRI had a higher detection rate in region IV compared to CT (0.89 vs. 0.61, p > 0.05). The level of agreement between the readers varied depending on the number of metastases and the specific region, with the highest agreement observed in region III and the lowest observed in region I. Conclusions: In patients with advanced melanoma, WB-MRI has the potential to serve as an alternative to CT with comparable diagnostic accuracy and confidence across most regions. The observed limited sensitivity for the detection of pulmonary lesions might be improved through dedicated lung imaging sequences.

Abstract In this work we study type IIB Calabi-Yau orientifold compactifications in the presence of space-time filling D7-branes and O7-planes. In particular, we conclude that α′2 g s -corrections to their DBI actions lead to a modification of the four-dimensional N $$ \mathcal{N} $$ = 1 Kähler potential and coordinates. We focus on the one-modulus case of the geometric background i.e. h 1,1 = 1 where we find that the α′2 g s -correction is of topological nature. It depends on the first Chern form of the four-cycle of the Calabi-Yau orientifold which is wrapped by the D7-branes and O7-plane. This is in agreement with our previous F-theory analysis and provides further evidence for a potential breaking of the no-scale structure at order α′2 g s . Corrected background solutions for the dilaton, the warp-factor as well as the internal space metric are derived. Additionally, we briefly discuss α′-corrections from other Dp-branes.

Abstract In this work we analyze F-theory and Type IIB orientifold compactifications to study α′-corrections to the four-dimensional, N $$ \mathcal{N} $$ = 1 effective actions. In particular, we obtain corrections to the Kählermoduli space metric and its complex structure for generic dimension originating from eight-derivative corrections to eleven-dimensional supergravity. We propose a completion of the G 2 R 3 and (∇G)2 R 2-sector in eleven-dimensions relevant in Calabi-Yau fourfold reductions. We suggest that the three-dimensional, N $$ \mathcal{N} $$ = 2 Kähler coordinates may be expressed as topological integrals depending on the first, second, and third Chern-forms of the divisors of the internal Calabi-Yau fourfold. The divisor integral Ansatz for the Kähler potential and Kähler coordinates may be lifted to four-dimensional, N $$ \mathcal{N} $$ = 1 F-theory vacua. We identify a novel correction to the Kähler potential and coordinates at order α′ 2, which is leading compared to other known corrections in the literature. At weak string coupling the correction arises from the intersection of D7-branes and O7-planes with base divisors and the volume of self-intersection curves of divisors in the base. In the presence of the conjectured novel α′-correction resulting from the divisor interpretation the no-scale structure may be broken. Furthermore, we propose a model independent scenario to achieve non-supersymmetric AdS vacua for Calabi-Yau orientifold backgrounds with negative Euler-characteristic.

This review provides a detailed introduction to chiral gauge theories, renormalization theory, and the application of dimensional regularization with the non-anticommuting BMHV scheme for γ5. One goal was to show how chiral gauge theories can be renormalized despite the spurious breaking of gauge invariance and how to obtain the required symmetry-restoring counterterms. A second goal was to familiarize the reader with the theoretical basis of the renormalization of chiral gauge theories, the theorems that guarantee the existence of renormalized chiral gauge theories at all orders as consistent quantum theories. Relevant topics include BPHZ renormalization, Slavnov–Taylor identities, the BRST formalism, and algebraic renormalization, as well as the theorems guaranteeing that dimensional regularization is a consistent regularization/renormalization scheme. All of these, including their proofs and interconnections, are explained and discussed in detail. Further, these theoretical concepts are illustrated in practical applications with the example of an Abelian and a non-Abelian chiral gauge theory. Not only the renormalization procedure for such chiral gauge theories is explained step by step, but also the results of all counterterms, including the symmetry-restoring ones, necessary for the consistent renormalization, are explicitly provided.

In this work we analyze the role of α′-corrections to type IIB orientifold compactifications in Kähler moduli stabilization and inflation. In particular, we propose a model independent scenario to achieve non-supersymmetric Minkowski and de Sitter vacua for geometric backgrounds with positive Euler-characteristic and generic number of Kähler moduli. The vacua are obtained by a tuning of the flux superpotential. Moreover, in the one-modulus case we argue for a mechanism to achieve model independent slow-roll.

Although muscle development has been widely studied in Drosophila melanogaster there are still many gaps in our knowledge, and it is not known to which extent this knowledge can be transferred to other insects. To help in closing these gaps we participated in a large-scale RNAi screen that used the red flour beetle, Tribolium castaneum, as a screening platform. The effects of systemic RNAi were screened upon double-stranded RNA injections into appropriate muscle-EGFP tester strains. Injections into pupae were followed by the analysis of the late embryonic/early larval muscle patterns, and injections into larvae by the analysis of the adult thoracic muscle patterns. Herein we describe the results of the first-pass screens with pupal and larval injections, which covered ∼8,500 and ∼5,000 genes, respectively, of a total of ∼16,500 genes of the Tribolium genome. Apart from many genes known from Drosophila as regulators of muscle development, a collection of genes previously unconnected to muscle development yielded phenotypes in larval body wall and leg muscles as well as in indirect flight muscles. We then present the main candidates from the pupal injection screen that remained after being processed through a series of verification and selection steps. Further, we discuss why distinct though overlapping sets of genes are revealed by the Drosophila and Tribolium screening approaches.

Abstract Purpose Cognitive impairment and reduced quality of life is a common condition in patients with heart failure (HF). Percutaneous mitral valve repair using (PMVR) MitraClip (MC) has emerged as a promising interventional tool, reducing all-cause mortality and hospitalization as well as increasing cognitive functioning and quality of life. However, the benefit of HF patients with severely depressed cognitive functioning remains unknown. Methods We assessed cognitive functioning (figural memory—FGT, executive function—TOL, TMT B), psychosocial functioning (depression—PHQ-9, quality of life—SF36), and clinical parameters (echocardiography, 6-min walk test distance, and cardiac biomarkers) 1 day before (t0) and 6 weeks after (t1) MC intervention in HF patients (n = 40). First, paired sample t tests were conducted to uncover improvements in cognitive functioning post-MC intervention. Second, the COGBAT Norm-sample, a representative age-matched healthy sample, was used to compare participants’ individual scores. Third, bivariate linear regressions were calculated for all key predictors of the detected improvements in cognitive functioning post-MC intervention (t1–t0). Results Following the MC intervention, we found significant improvements in figural memory, executive functioning, and psychosocial functioning. Most of the patients with depressed executive functioning before the MC intervention showed post-intervention test scores within the normal range (> 50th percentile; t0 22.5% vs. t1 60%) as compared to the normative COGBAT sample. Regression analyses revealed that lower baseline scores in planning ability before the MC intervention (t0) were associated with greater planning ability (TOL; B = − 0.78, 95% CI − 1.04 to − 0.53), figural memory (FGT; B = − 0.26, 95% CI − 0.44 to − 0.07), and cognitive flexibility (TMT B; B = − 0.36, 95% CI − 0.50 to − 0.23) improvement post-MC intervention (t1–t0). Psychosocial functioning and age were not associated with these improvements. Conclusions Patients with depressed executive functioning showed the greatest benefit from the MC intervention regarding cognitive functioning. Age and psychological functioning seem less important for cognitive performance improvements post-MC intervention. Hence, severely depressed cognitive functioning in patients is not a contraindication for PMVR using MitraClip.

Current state-of-the-art engine condition monitoring is based on a minimum of one steady-state data point per flight. Due to the scarcity of available data points, there are difficulties distinguishing between random scatter and an underlying fault introducing a detection latency of several flights. Today’s increased availability of data acquisition hardware in modern aircraft provides continuously sampled in-flight measurements, so-called full-flight data. These full-flight data give access to sufficient data points to detect faults within a single flight, significantly improving the availability and safety of aircraft. Artificial neural networks are considered well suited for the timely analysis of an extensive amount of incoming data. This article proposes uncertainty quantification for artificial neural networks, leading to more reliable and robust fault detection. An existing approach for approximating the aleatoric uncertainty was extended by an Out-of-Distribution Detection in order to take the epistemic uncertainty into account. The method was statistically evaluated, and a grid search was performed to evaluate optimal parameter combinations maximizing the true positive detection rates. All test cases were derived based on in-flight measurements of a commercially operated regional jet. Especially when requiring low false positive detection rates, the true positive detections could be improved 2.8 times while improving response times by approximately 6.9 compared to methods only accounting for the aleatoric uncertainty.

Anomalous diffusion or, more generally, anomalous transport, with nonlinear dependence of the mean-squared displacement on the measurement time, is ubiquitous in nature. It has been observed in processes ranging from microscopic movement of molecules to macroscopic, large-scale paths of migrating birds. Using data from multiple empirical systems, spanning 12 orders of magnitude in length and 8 orders of magnitude in time, we employ a method to detect the individual underlying origins of anomalous diffusion and transport in the data. This method decomposes anomalous transport into three primary effects: long-range correlations (“Joseph effect”), fat-tailed probability density of increments (“Noah effect”), and nonstationarity (“Moses effect”). We show that such a decomposition of real-life data allows us to infer nontrivial behavioral predictions and to resolve open questions in the fields of single-particle tracking in living cells and movement ecology.

ObjectiveCognitive impairments are a frequent and difficult to treat symptom in patients with schizophrenia and the strongest predictor for a successful reintegration in occupational and everyday life. Recent research suggests transcranial direct current stimulation (tDCS) to enhance cognition in this patient group. However, the question regarding its acute effectiveness on executive functions remains largely unanswered. Here, we examined in a randomized, double blind, sham-controlled repeated-measures design the impact of tDCS on performance in several executive functions in patients with schizophrenia, schizoaffective disorder or acute transient psychotic disorder.MethodsPatients (N = 48) were tested twice using standardized, well-constructed and clinically validated neuropsychological tests assessing verbal working memory, response inhibition, mental flexibility and problem solving. In session 1 they solely underwent the neuropsychological assessment, whereas in session 2 they additionally received 2 mA of anodal tDCS stimulation over the left dorsolateral prefrontal cortex (DLPFC), cathode right supraorbital ridge, or sham stimulation for 20 minutes.ResultsPatients of both groups were not able to correctly discriminate the type of stimulation received confirming the success of the blinding procedure. However, analyzing the whole sample the change in performance from session 1 to session 2 was the same in the verum as in the sham condition (all p >.5). Moreover, a subsequent exploratory analysis showed that performance in the response inhibition task was worse for patients that engaged in the task within 20 minutes after the end of the verum stimulation.ConclusionHence, 2 mA of anodal tDCS applied over the left DLPFC did not acutely enhance executive functions in patients with schizophrenia or related disorders but impaired performance in the response inhibition task shortly after. Future studies should continue to seek for effective stimulation configurations for this patient group.Clinical trial registrationThe study is registered in the "Deutsches Register Klinischer Studien DRKS", German Clinical Trial Register and has been allocated the following number: DRKS00022126.