Search

As of May 19, 2021, Ethiopia was among the five African countries most affected by COVID-19. A cross-sectional design was used to assess the level of knowledge, perceptions, and practices of bus station workers about COVID-19 between August 25 and September 17, 2020. Face-to-face interviewer-administered questionnaires were used. To identify the factors associated with the dependent variables, simple and multiple binary logistic regression analyses were used. A P value < 0.05 was considered significant. Data were analyzed using SPSS version 20 software. In this study, 427 workers from three bus stations participated. Approximately 84.5%, 84.8%, and 81.3% of the workers had good knowledge, positive perceptions, and good practices, respectively. Multivariable logistic regression analysis showed that workers with a monthly income of 3,001 to 4,000 birr were about four times more likely to have poor knowledge compared with higher income workers. Those workers with poor knowledge were 2.4 times, and security workers were 3.7 times, more likely to have poor practices compared with workers with good knowledge and drivers, respectively. In conclusion, workers used in security and those who had poor knowledge regarding COVID-19 failed to exhibit effective preventative practices against the virus.

Introduction: Lifestyle interventions as supper arranging and exercise assume a significant job in a Diabetes Self-Management Education (DSME) program. The impact of poly-pharmacy on way of life changes, for example, nourishment and exercise isn't surely known. Deciding and evaluating patient's dimension of enactment and its association with physical action level, supper arranging, and poly-pharmacy in patients with Type II diabetes is a significant standard for Diabetes Self-Management mediations. Objective: The aim of this study was to determine patient activation levels and associated factors among type II diabetic patents attending diabetic clinic at hospitals in Addis Ababa. Methods: Institutional based cross-sectional examination configuration was led. This investigation was led on 423 Type II diabetic patients going to diabetic facilities at emergency clinics in Addis Ababa. Study members were chosen by utilizing orderly arbitrary examining procedure. A pre-tried organized survey was utilized to gather the information. Understanding Activation Measure (PAM-13) was utilized to survey tolerant actuation levels. Information were entered and dissected utilizing SPSS rendition 23 for windows. Concentrate members' qualities were portrayed as far as mean (Standard deviation) and recurrence (extent). Bivariate examination and various calculated relapse investigations were completed to recognize free factors related with patient enactment among sort II diabetes patients. Results: The mean (SD) age of the study participants was 55.7(±9.8) years. Majority of the study participants, 319 (77.8%) had low meal planning knowledge, 62.4% of patients involved in low physical activity and 82.2% had poor glycemic control. About 75.6% of the patients had low activation and the remaining 24.4% had high activation. The independent factors associated with lower activation were Illiterate educational status (AOR=2.4, 95% CI: 1.5-3.3), low physical activity (AOR=1.8, 95% CI: 1.4-2.9), low meal planning knowledge (AOR=1.5, 95% CI: 1.3-2.4), chronic comorbidities (AOR=2.1, 95% CI: 1.6-3.9) and poor glycemic control (AOR = 4.2, 95% CI: 2.4–7.5). Conclusions: The findings revealed that majority of diabetic II patients had low activation; indicating patients had low knowledge and understanding regarding the influence of lifestyle in diabetes management. Illiterate educational status, low physical activity, low meal planning knowledge, chronic comorbidities and poor glycemic control were significantly associated with lower activation.

Background and aim Self-medication (SM) is one part of self-care which is known to contribute to primary health care. If practiced appropriately, it has major benefits for the consumers such as self-reliance and decreased expense. However, inappropriate practice can have potential dangers such as incorrect self-diagnosis, dangerous drug-drug interactions, incorrect manner of administration, incorrect dosage, incorrect choice of therapy, masking of a severe disease, and/or risk of dependence and abuse. The main objective of this study was to assess the prevalence and determinants of the self-medication practice (SMP) in Addis Ababa. Methodology A community based cross-sectional study was conducted among selected households in Addis Ababa from April 2016 to May 2016, with a recall period of two months before its conduction. Trained data collectors were employed to collect the data from the 604 sampled participants using pre-tested and validated questionnaires. Result Among the 604 participants involved in this study, 422 (69.9%) were female and 182 (30.1%) were male and there was a mean age of 41.04 (± 13.45) years. The prevalence of SM in this study was 75.5%. The three most frequently reported ailments were headache 117 (25.7%), abdominal pain 59 (12.9%) and cough 54 (11.8%). The two main reasons for SM were mildness of illness 216 (47.4%) and previous knowledge about the drug 106 (23.2%). The two most frequently consumed medications were paracetamol 92 (20.2%) and traditional remedies 73 (16.0%), while drug retail outlets 319 (83.3%) were the main source of drugs. The two most frequently reported source of drug information were health professionals 174 (45.4%) and experience from previous treatment 82 (21.4%). Moreover, there were statistically significant differences among respondents who reported practicing SM based on income and knowledge about appropriate SMP. Conclusion and recommendation Self-medication was practiced with a range of drugs from the conventional paracetamol and NSAIDs to antimicrobials. Being that the practice of SM is inevitable, health authorities and professionals are highly demanded to educate the public not only on the advantages and disadvantages of SM but on its proper use.

The aim of this study was to review the antimalarial drug treatment and its resistance during the course of therapy. Malaria affects the populations of tropical and subtropical areas world-wide, as well as an increasing number of travellers to these areas. Although malaria is found in over 100 countries, the major burden of disease is carried by the nations of Africa, where over 90% of all deaths from falciparum malaria are recorded and where the high levels of morbidity and transmission place considerable strains on public health services and economic infrastructure. In the absence of effective vaccines, management of the disease has depended largely upon chemotherapy and chemoprophylaxis. The number of available and effective antimalarial drugs is quickly dwindling due to different cause. This is mainly because a number of drug resistance-associated mutations in malaria parasite genes, such as crt, mdr1, dhfr/dhps and others, have led to widespread resistance to all known classes of antimalarial compounds. Unfortunately, malaria parasites have started to exhibit some level of resistance in Southeast Asia even to the most recently introduced class of drugs, artemisinins. Molecular evolutionary and population genetic approaches will greatly facilitate our understanding of the evolution and spread of parasite drug resistance and will contribute to developing strategies for better control of malaria. While there is much need, the antimalarial drug development pipeline remains woefully thin, with little chemical diversity and there is currently no alternative to the precious artemisinins. In general, four basic methods have been routinely used to study or measure antimalarial drug resistance: in vivo, in vitro, animal model studies and molecular characterization. This review endeavors to present the background facts and treatment and more on the current status of antimalarial drug resistance, what their causes, mechanisms, spread and management are and future perspective with antimalarial treatment. Furthermore, findings from this review will be useful to clinical researchers, health planners, policy makers and stakeholders and others concerned for malaria patients.

Objective To characterise acute poisonings in pregnant and non-pregnant women treated at emergency departments of government hospitals in Addis Ababa, Ethiopia, between 2010 and 2015. Methods All data for acutely poisoned women were retrospectively collected from patient medical charts at the emergency departments of Saint Paul's Hospital Millennium Medical College, Ras Desta Memorial Hospital, Yekatit 12 Hospital Medical College and Zewditu Memorial Hospital. Data were collected by extraction questionnaire and analysed using SPSSv. 20 statistical software. Results During the study period, 998 cases of acutely poisoned women were listed in the hospital registries. Of these, complete data for inclusion in the study were available for 592. 36.3% of the study participants were in the age group of 20–24, with a mean (±SD) age of 23.03 (±6.3) years. 80.9% were from Addis Ababa; 4.6% were pregnant. The mean arrival time of all cases was 4.14 h. 85.5% of all study cases were due to intentional self-poisoning, of whom 42.1% were discharged without complications. The most common poisons were bleach and organophosphates; 25.9% of pregnant cases and 32.6% of non-pregnant cases were poisoned by bleach; and 18.5% of pregnant cases and 18.9% of non-pregnant cases had organophosphate poisoning. 0.7% had a history of poisoning; all were non-pregnant women. The common route of poison exposure was oral, and the case fatality rate of organophosphate poisoning in pregnant and non-pregnant women was 20 and 1.87%, respectively. The pre-hospital intervention for the majority of the women was milk, in 12.0% of cases. Conclusion Acute poisoning remains a public health problem in our community. Bleach is the most common poisons. Our present findings indicate the necessity of educational programmes on preventable reasons of acute poisonings and their outcomes on pregnant and non-pregnant women.

Context: Moringa stenopetala (Baker f) Cufodontis is an evergreen tree of approximately 5 to 10 m height and widely distributed in the Southern parts of Ethiopia with numerous nutritional and medicinal purposes. Objective: The aim of the study was to evaluate the effect of hydro-ethanolic extract of M. stenopetala leaves using in-vivo mice model of diuresis. Methods: Furosemide (10 mg/kg), normal saline (1 ml/100 g), and extract doses (150, 250, 350, 500 and 1000 mg/kg) of body weight were used as standard, control and test substance respectively. All substances were administered orally. The urine output and electrolyte concentration of Na+, K+ and Cl- were determined. Results: At all doses the experimental group had a significant urine output at 0.5 hour and 1 hour (P < 0.001) compared to standard and control. After 2.5 hours, at 500 mg/kg the extract showed an increased urine output compared to the control as well as the extract doses of 150, 250, 350 and 1000 mg/kg (P < 0.05). The excretion of Na+ and Cl- was significantly increased at 250 and 350 mg/kg test doses (P < 0.001) compared to control. At 500 and 1000 mg/kg, there is a comparable Na+ and Cl- excretion and a significant K+ excretion ((at 500 (P < 0.01) and 1000 mg/kg (P < 0.01)) compared to standard and control respectively. Conclusion: The outcome of the study demonstrated the diuretic activity of the hydro-ethanolic extracts of M. stenopetala leaves which is in agreement to the folkloric use of the plant for the management of hypertension and heart failure.