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1. Angiomotin-Like Protein 1 Controls Endothelial Polarity and Junction Stability During Sprouting Angiogenesis.

Author

Yujuan Zheng, Vertuani, Simona, Nyström, Staffan, Audebert, Stéphane, Meijer, Inëz, Tegnebratt, Tetyana, Borg, Jean-Paul, Uhlén, Per, Majumdar, Arindam, and Holmgren, Lars

Subjects
CELL polarity, CELL migration, ENDOTHELIUM, TIGHT junctions, SMALL interfering RNA, LABORATORY mice
Abstract

The article presents a study which identifies the function of angiomotin-like protein 1 (AmotL1) in comparison to angiomotin (Amot) in the polarization and migration of endothelial cell (EC). It states that (Amot) is a coiled-coil protein in ECs which controls migration, formation of tight junction (TJ) and cell polarity. Results of the small interfering ribonucleic acid-(RNA) mediated silencing in mouse cells show that AmotL1 has the same effects with Amot on EC migration and TJ formation.

Published
2009
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