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5. Kruppel-associated boxes are potent transcriptional repression domains

Author

Margolin, Judith F., Friedman, Josh R., Meyer, Wolfram K.-H., Vissing, Henrik, Thiesen, Hens-Jurgen, and Rauscher, Frank J., III

Subjects
Genetic transcription -- Regulation, Amino acid sequence -- Analysis, Science and technology
Abstract

The Kruppel-associated box (KRAB) when fused to a heterologous DNA-binding domain from the yeast GAL4 protein, behaves as a DNA binding-dependent transcriptional repressor. The KRAB domain is found in the amino-terminal regions of several Kruppel-class Cys2His2 zinc finger proteins. KRAB is a conserved 75-aa region with two amphipathic alpha-helices.

Published
1994

20. Patents: a tool to bring innovation from the lab bench to the marketplace.

Author

Li ZY and Meyer W

Subjects
Biotechnology legislation & jurisprudence, Disclosure, Yeasts, Inventions legislation & jurisprudence, Laboratories, Patents as Topic
Abstract

Intellectual property (IP) is creations of the mind. Protecting IP through patents is an important venue for a researcher to reap rewards from his scientific endeavors. It is part of a competitive strategy for bringing one's invention to the marketplace. Using the US and European patent systems as examples, we provide here an overview of how patents protect innovation, with a focus on biotechnology. We explain what a patent is, what a patent owner can do with a patent, and how patents are granted. The article ends with some recent examples of noteworthy patents in the field of yeast research.

Published
2014
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