1. Protective effects of a novel water-soluble biphenyl compound WLP-S-14 against acute-on-chronic liver failure in rats.
- Author
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Wang, Shao-Yuan, Li, Mei, Miao, Lu-Yang, Wu, Song, Tong, Yuan-Feng, Zhang, Wen-Xuan, Zhang, Yu-Yang, and Sun, Hua
- Subjects
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AMINOTRANSFERASES , *ANIMAL experimentation , *APOPTOSIS , *BIOMARKERS , *BIOCHEMISTRY , *BIOLOGICAL models , *BIPHENYL compounds , *BLOOD coagulation , *CARBOHYDRATES , *HISTOLOGICAL techniques , *INTERLEUKINS , *LIVER , *LIVER failure , *MOLECULAR structure , *MORTALITY , *PHYSIOLOGIC salines , *RATS , *SERUM , *SURVIVAL , *TUMOR necrosis factors , *WESTERN immunoblotting , *LIPOPOLYSACCHARIDES - Abstract
This study investigated the therapeutic effects of a water-soluble biphenyl compound, WLP-S-14, in acute-on-chronic liver failure (ACLF). Wistar rats were injected intraperitoneally with porcine serum twice a week for 8 weeks prior to administration of 600 mg/kg D-galactosamine and 50 μg/kg lipopolysaccharide to induce ACLF. Study groups were treated intravenously with saline or with 100 or 200 mg/kg WLP-S-14. WLP-S-14 ameliorated ACLF with significant reductions in the mortality rate and transaminase levels, indicating improved liver function. The mechanism underlying these effects may involve decreased levels of tumor necrosis factor-α and interleukin-6, with associated inhibition of apoptotic pathways. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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