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STRESZCZENIEWstęp: Celem pracy było przedstawienie diagnostyki i terapii pacjentki z dysfunkcją stawu skroniowo­‍-żuchwowego spowodowane zmianami o charakterze dysplazji włóknistej głowy wyrostka kłykcia żuchwy po stronie prawej.Materiał i metody: W procesie diagnostycznym struktur kostnych wykorzystano technikę radiografii cyfrowej – system Digora, natomiast ruchomość żuchwy oceniano za pomocą techniki aksjograficznej. Pomiary przeprowadzono za pomocą urządzenia Cadiax (Diagnostic) Gamma.Wnioski: Zastosowane metody diagnostyczne pozwoliły potwierdzić diagnozę i ustalić plan leczenia, który obejmował zastosowanie aparatu terapeutycznego. Przeprowadzone procedury przyniosły pozytywny efekt terapeutyczny.

Xeroderma pigmentosum is a rare autosomal recessive disease that is associated with a severe deficiency in nucleotide excision repair. The presence of a distinct the nucleotide excision repair (NER) mutation signature in melanoma suggests that perturbations in this critical repair process are likely to be involved with disease risk. We hypothesized that persons with polymorphic NER gene(s) are likely to have reduced NER activity and are consequently at an increased risk of melanoma development. We assessed the association between 94 SNPs within seven XP genes (XPA-XPG) and the melanoma risk in the Polish population. We genotyped 714 unselected melanoma patients and 1,841 healthy adults to determine if there were any polymorphisms differentially represented in the disease group. We found that a significantly decreased risk of melanoma was associated with the Xeroderma pigmentosum complementation (XPC) rs2228000-CT genotype (odds ratio [OR] = 0.15; p < 0.001) and the rs2228000-TT genotype (OR = 0.11; p < 0.001) compared to the reference genotype. Haplotype analysis within XPC revealed the rs2228001-A + G1475A-G + G2061A-A + rs2228000-T + rs3731062-C haplotype (OR = 0.26; p < 0.05) was associated with a significantly decreased disease risk. The haplotype analysis within the Xeroderma pigmentosum group D (XPD) showed a modest association between two haplotypes and a decrease in melanoma risk. There were no major differences between the prevalence of the XP polymorphisms among young or older patients with melanoma. Linkage disequilibrium of XPC: rs2228001, G1475A, G2061A, rs2228000 and rs3731062 was found. The data from our study support the notion that only XPC and XPD genes are associated with melanoma susceptibility. What's new? Frequent mutation of the nucleotide excision repair (NER) system in both malignant melanoma and the inherited skin disease Xeroderma pigmentosum (XP) has led to speculation about whether XP may influence melanoma risk. Here, haplotype analysis of seven XP genes (XPA-XPG) in a Polish population uncovered a significant association between an XPC haplotype and decreased risk of malignant melanoma. Modest associations were also found for two XPD haplotypes. The findings contribute to the growing body of evidence that has implicated XPC and XPD polymorphisms as factors in melanoma susceptibility.

Background Observational studies have reported an inverse relationship between selenium status (blood or toenail) and the risk of laryngeal cancer; however, the impact of low serum selenium level on survival has not been evaluated. Methods We conducted a prospective study of 296 patients diagnosed with laryngeal cancer in Szczecin, Poland. Serum selenium was measured at diagnosis and prior to treatment. Patients were followed from the date of diagnosis to death at five years. Vital status was obtained by linkage to the Polish National Death Registry. Results The five-year survival after diagnosis was 82.0% (95% CI: 68% to 91%) for individuals in the highest quartile of serum selenium (> 66.8 μg/L) and was 28.6% (95% CI 19% to 42%) for individuals in the lowest quartile (

Background : There is continuing interest in identifying low-penetrance genes which are associated with an increased susceptibility to common types of cancer, including malignant melanoma. Methods : We sought to examine the association between four VDR common variants (rs1544410, rs731236, rs10735810, rs4516035) and the risk of melanoma in the Polish population. We also determined the prevalence of compound carriers of VDR and known MM genetic risk factors MC1R and CDKN2A (A148T) variants. We examined 763 unselected melanoma cases, 763 healthy adults matched for sex and age with the melanoma cases and 777 newborns. Results : None of the VDR variants alone or as compound carriers of two or more of the VDR genotypes were associated with MM risk. There were no major differences between the prevalences of the examined variants among patients with MM on UV-exposed and UV-non exposed skin areas, as well as among early-onset and late-onset cases. We found no association between VDR and MC1R or between VDR and CDKN2A common variants. A statistically significant over-representation of one VDR haplotype: rs731236_A+rs1544410_T (OR=3.2, p =0.02) was detected. Linkage disequilibrium of rs1544410 and rs731236 was confirmed. Conclusion : To answer the question, whether VDR can be regarded as melanoma susceptibility gene, additional, large multi-center association studies have to be performed.

Summary Represented the way of orbital floor reconstruction using coronoid process of the mandible pedicled on temporal muscle. The clinical evaluation of vascularised bone graft from coronoid process confirmed their usefulness in the face reconstruction surgery.

The correct name of the ninth author is: Piotr Waloszczyk. The correct affiliation for this author is: Independent Laboratory of Pathology, Zdunomed, Szczecin, Poland.

Selenium deficiency has been suggested by several studies to be associated with cancer risk. We conducted a case-control study in Szczecin, a region of northwestern Poland, on 86 cases of lung cancer, 87 cases of laryngeal cancer and an equal number of healthy controls. We studied the serum level of selenium and genotypes for four variants in four selenoprotein genes (GPX1, GPX4, TXNRD2 and SEP15) and the odds of being diagnosed with lung or laryngeal cancer. Among lung cancer cases, the mean selenium level was 63.2 µg/l, compared to a mean level of 74.7 µg/l for their matched controls (p 80 µg/l) was associated with an odds ratio of 0.10 (95% CI 0.03 to 0.34; p = 0.0002) for lung cancer and 0.24 (95% CI 0.10 to 0.59; p = 0.002) for laryngeal cancer. In four selenoproteins studied here we found a modest associations of genetic variants in GPX1 and GPX4 with lung and TXNRD2 with laryngeal cancer risk. We analyzed iron (Fe) level in serum of 77 lung cancer patients and 77 matched controls. We did not find difference in mean Fe level between cases and controls (1053.05 µg/l and 1059.39 µg/l). However, we found that Fe level in the lowest and highest quartiles was associated with a significant lung risk enhancement when compared to a serum Fe level in the middle quartiles (OR 0.3, p 0.02). We also observed that the relationship between the level of Fe and Se could be an important factor for lung cancer risk.

Selenium deficiency has been suggested by several studies to be associated with cancer risk. We conducted a case-control study in Szczecin, a region of northwestern Poland, on 86 cases of lung cancer, 87 cases of laryngeal cancer and an equal number of healthy controls. We studied the serum level of selenium and genotypes for four variants in four selenoprotein genes (GPX1, GPX4, TXNRD2 and SEP15) and the odds of being diagnosed with lung or laryngeal cancer. Among lung cancer cases, the mean selenium level was 63.2 µg/l, compared to a mean level of 74.7 µg/l for their matched controls (p 80 µg/l) was associated with an odds ratio of 0.10 (95% CI 0.03 to 0.34; p = 0.0002) for lung cancer and 0.24 (95% CI 0.10 to 0.59; p = 0.002) for laryngeal cancer. In four selenoproteins studied here we found a modest associations of genetic variants in GPX1 and GPX4 with lung and TXNRD2 with laryngeal cancer risk. In this region of endemic low selenium level, there is a strong inverse association between the level of serum selenium and the risks of lung and laryngeal cancer.

The aim of the study was to examine whether pleomorphic adenoma of salivary glands can occur on the basis of constitutional BRCA-1 mutations.Two hundred and sixty-eight patients affected by mixed tumour of salivary glands were examined for occurrence of three BRCA-1 mutations dominating in Poland.BRCA-1 mutation was detected in only one of the patients, a female affected by breast cancer and pleomorphic adenoma of parotid gland. Parotid gland tumour showed clinical and histopathological features of typical pleomorphic adenoma with no morphological features of high-grade malignancy, which are characteristic of BRCA-1-dependent tumours.Considering the low frequency of BRCA-1 mutation in the examined group and also the absence of features characterizing BRCA-1-dependent tumours in the only BRCA-1-positive case, pleomorphic adenoma of salivary glands should not be recognized as a BRCA-1 dependent tumour.

Represented the way of orbital floor reconstruction using coronoid process of the mandible pedicled on temporal muscle. The clinical evaluation of vascularised bone graft from coronoid process confirmed their usefulness in the face recon struction surgery.

The focus of this paper is the evaluation of usability of various nose skin reconstruction methods applied after removal of a skin cancer in the Teaching Hospital of Maxillofacial Surgery at the Pomeranian Academy of Medicine in Szczecin in 1975-2004.The research material consisted of 285 patients who underwent a surgical treatment of nose skin cancers located in various skin areas. In 67 cases, the tumour was situated on a nostril flare, in 42--on the nose tip, in 98--on the bridge and in 68--on one of its sides, most frequently, near the corner of the eye. Said tumours often covered more than one of the above-mentioned areas or even all of them. Reconstruction planning and performance was an integral part of the surgical treatment. The tumour amputation was preceded by an assessment of the quantity and quality of tissues necessary for filling in the lesions. Lesions located on the nose surface were covered by free skin grafts. In the case of nostril flare tumours, they were filled in with grafts composed of skin and cartilaginous tissue from the ear. Lesions including all nose layers were most frequently (in 136 cases) covered with various types of axially vascularised frontal skin flaps i.e. by the middle or temporal part of the frontal flap. In the case of elderly people the nasolabial flaps were used.In most cases, both the aesthetic and functional effects were very good. What appeared to be the most difficult reconstruction case was the restoration of the nasal bone structures after their complete amputation.Due to the thickness, colour and easiness of preparation of the middle frontal flap, it is considered to be the best material for reconstruction of the nose.

Operative treatment of developmental anomalies were presented in actual work carried out in Maxillo-Facial Clinic PMA in Szczecin. Mesiocclusion was the most frequent anomaly, followed by microgenia, joint ankylosis of tempora mandibular, next laterogenia and first and second branchial arch syndrome. The operative treatment was finished by placing and fixing the bones in new changed position. The obtained results indicated that this type of management is the best effective in correction of visceral cranium development anomalies, it assure quick maintenance of good oral hygiene as well as stabilisation and functioning jaws.

In recent years, the osteosynthesis plate has became very popular due to its quality during treatment of visceral cranium bone fractures. It is recommended to be used for stabile fusion of multi segment fractures. In the Maxillo-Facial Surgery Clinic of PMA Szczecin the presented method is applied from the mid-80-ies of the last century. Experience and obtained results permit as to state that osteosynthesis plate of visceral cranium posttraumatic fractures provides most efficient method in their treatment. It allows to establish one-time anatomical functional bone fusion, soon return to correct stomatognathic system, shortens hospitalizations time, thus securing speedy return to normal life. Analyzing the complications it was found out that in the majority of cases the decisive significance referred to: the condition of patients, time of reporting after trauma, biomechanical fusion features as wall as skill of the operator. Not always the complications were the results of the applied method.

Surgical treatment of oral cavity neoplasms consists of the resection of tumor surrounded by a healthy tissue margin. This study is aimed at an objective, qualitative and quantitative evaluation of breathing disturbances and dyspnoea after the resection of oral cavity structures, throat structures and muscles of the neck. For the purpose of evaluating the above-mentioned disturbances an attempt was made to carry out pulse oximetry examination.We have examined 50 persons after the resection of oral cavity structures, throat structures and muscles of the neck in Maxillofacial Clinic of Pomeranian Medical Academy in Szczecin. The examinations were performed by pulse oximetry set during sleep before and after operations. The patients were divided into three groups according to the type of removed structures which included: lateral part of the mandible; mental part of the mandible; part of the tongue.The results of examinations obtained gave rise results as: pulse oximetry examination revealed an increased incidence of blood desaturation episodes and a decrease in minimum saturation level.Surgical treatment of oral cavity neoplasms leads to breathing disturbances. Apnoea episodes cause a drop in the arterial blood saturation with oxygen.

Repeatable epiglottic movement patterns were recorded during a videofluoroscopic swallow evaluation of 95 patients who had undergone a total or partial glossectomy due to a neoplasm. Because no epiglottic function assessment was performed preoperatively, for the purpose of this study it was assumed that epiglottic mobility was “normal” during this time and that all abnormalities found afterward resulted from the growth of the neoplasm and the glossectomy. It was noted that in the early postoperative period, absence of epiglottic movement was accompanied by aspiration and made swallowing incompetent in a majority of cases (9 of 10). A correlation of movement between the epiglottis and the extent of oral tissue excision was found. Epiglottic mobility was evaluated as “normal” in 72% of the patients, i.e., in 67 of 91 (74%) patients after a partial or nearly total glossectomy and in 1 of 4 people who underwent a total glossectomy. In the subgroup (16%) of patients who underwent a total or nearly total glossectomy and then had videofluoroscopic examinations, 60% of the cases had normal epiglottic movements and 40% had an immobile epiglottis. Compensatory mechanisms implemented by the patients on their own initiative, such as additional swallows and prolonged apnea during deglutition, enabled them to avoid aspiration. However, upward head movement and downward chin tilting during deglutition as compensatory mechanisms used by patients with no epiglottic movement did not reduce the aspiration risk in the early postoperative period and were found to accompany incompetent swallowing attempts.