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250 results on '"Miglioresi L"'

1. T.06.9: PT1 CANCER OF THE COLON AND RECTUM (CCR): RETROSPECTIVE EVALUATION AND FOLLOW-UP IN REAL PRACTICE

Author

Lisi, D., primary, Miglioresi, L., additional, Bruno, G., additional, Conti, L., additional, Lucidi, C., additional, D'Ovidio, V., additional, Vannella, L., additional, Foschia, F., additional, Cassieri, C., additional, La Gaetana, E., additional, Biancaniello, F., additional, Spinelli, I., additional, Pica, R., additional, and Fracasso, P., additional

Published
2024
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3. A Bayesian methodology to improve prediction of early graft loss after liver transplantation derived from the Liver Match study

Author

Angelico, M., Cillo, U., Fagiuoli, S., Strazzabosco, M., Caraceni, P., Toniutto, P.L., Nanni Costa, A., Salizzoni, Torino M., Romagnoli, R., Bertolotti, G., Patrono, D., De Carlis, L., Slim, A., Mangoni, J.M.E., Rossi, G., Caccamo, L., Antonelli, B., Mazzaferro, V., Regalia, E., Sposito, C., Colledan, M., Corno, V., Tagliabue, F., Marin, S., Vitale, A., Gringeri, E., Donataccio, M., Donataccio, D., Baccarani, U., Lorenzin, D., Bitetto, D., Valente, U., Gelli, M., Cupo, P., Gerunda, G.E., Rompianesi, G., Pinna, A.D., Grazi, G.L., Cucchetti, A., Zanfi, C., Risaliti, A., Faraci, M.G., Tisone, G., Anselmo, A., Lenci, I., Sforza, D., Agnes, S., Di Mugno, M., Avolio, A.W., Ettorre, G.M., Miglioresi, L., Vennarecci, G., Berloco, P., Rossi, M., Ginanni Corradini, S., Molinaro, A., Calise, F., Scuderi, V., Cuomo, O., Migliaccio, C., Lupo, L., Notarnicola, G., Gridelli, B., Volpes, R., Li Petri, S., Zamboni, F., Carbotta, G., Dedola, S., Nardi, A., Marianelli, T., Gavrila, C., Ricci, A., Vespasiano, F., Angelico, Mario, Nardi, Alessandra, Romagnoli, Renato, Marianelli, Tania, Corradini, Stefano Ginanni, Tandoi, Francesco, Gavrila, Caius, Salizzoni, Mauro, Pinna, Antonio D., Cillo, Umberto, Gridelli, Bruno, De Carlis, Luciano G., Colledan, Michele, Gerunda, Giorgio E., Costa, Alessandro Nanni, and Strazzabosco, Mario

Published
2014
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4. HCV NS3 sequencing as a reliable and clinically useful tool for the assessment of genotype and resistance mutations for clinical samples with different HCV-RNA levels

Author

Di Maio, V. C., Cento, V., Di Paolo, D., Aragri, M., De Leonardis, F., Tontodonati, M., Micheli, V., Bellocchi, M. C., Antonucci, F. P., Bertoli, A., Lenci, I., Milana, M., Gianserra, L., Melis, M., Di Biagio, A., Sarrecchia, C., Sarmati, L., Landonio, S., Francioso, S., Lambiase, L., Nicolini, L. A., Marenco, S., Nosotti, L., Giannelli, V., Siciliano, M., Romagnoli, D., Pellicelli, A., Vecchiet, J., Magni, C. F., Babudieri, S., Mura, M. S., Taliani, G., Mastroianni, C., Vespasiani-Gentilucci, U., Romano, M., Morisco, F., Gasbarrini, A., Vullo, V., Bruno, S., Baiguera, C., Pasquazzi, C., Tisone, G., Picciotto, A., Andreoni, M., Parruti, G., Rizzardini, G., Angelico, M., Perno, C. F., Ceccherini-Silberstein, F., Mariani, R., Paoloni, M., Iapadre, N., Grimaldi, A., Menzaghi, B., Quirino, T., Vecchiet, J., Bruzzone, B., De Maria, A., Di Biagio, A., Marenco, S., Nicolini, L. A., Picciotto, A., Viscoli, C., Casinelli, K., Monache, M. Delle, Lichtner, M., Mastroianni, C., Aghemo, A., Bruno, S., Cerrone, M., Colombo, M., Monforte, A. DʼArminio, Danieli, E., Donato, F., Gubertini, G., Landonio, S., Magni, C. F., Mancon, A., Micheli, V., Monico, S., Niero, F., Puoti, M., Rizzardini, G., Russo, M. L., Alfieri, R., Gnocchi, M., Orro, A., Milanesi, L., Baldelli, E., Bertolotti, M., Borghi, V., Mussini, C., Romagnoli, D., Brancaccio, G., Caporaso, N., Gaeta, G. B., Lembo, V., Morisco, F., Calvaruso, V., Craxì, A., Di Marco, V., Mazzola, A., Petta, S., DʼAmico, E., Cacciatore, P., Consorte, A., Palitti, V. Pace, Parruti, G., Pieri, A., Polilli, E., Tontodonati, M., Andreoni, M., Angelico, M., Antenucci, F., Antonucci, F. P., Aragri, M., Armenia, D., Baiocchi, L., Bellocchi, M., Bertoli, A., Biliotti, E., Biolato, M., Carioti, L., Ceccherini-Silberstein, F., Cento, V., Cerasari, G., Cerva, C., Ciotti, M., DʼAmbrosio, C., DʼEttorre, G., De Leonardis, F., De Sanctis, A., Di Maio, V. C., Di Paolo, D., Francioso, S., Furlan, C., Gallo, P., Gasbarrini, A., Giannelli, V., Gianserra, L., Grieco, A., Grieco, S., Lambiase, L., Lattanzi, B., Lenci, I., Malagnino, V., Manuelli, M., Merli, M., Miglioresi, L., Milana, M., Nosotti, L., Palazzo, D., Pasquazzi, C., Pellicelli, A., Perno, C. F., Romano, M., Santopaolo, F., Santoro, M. M., Sarmati, L., Sarrecchia, C., Sforza, D., Siciliano, M., Sorbo, M. C., Spaziante, M., Svicher, V., Taliani, G., Teti, E., Tisone, G., Vespasiani-Gentilucci, U., Vullo, V., Mangia, A., Babudieri, S., Maida, I., Melis, M., Mura, M. S., Falconi, L., Di Giammartino, D., and Tarquini, P.

Published
2016
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8. Worse Graft Survival in HCV-Infected Transplanted Females Receiving a Male Donor Graft. The Liver Match Study.: Abstract# O-164

Author

Romagnoli, R., Rossi, M., Gerunda, G. E., Pinna, A. D., Agnes, S., Spada, M., Colledan, M., Tisone, G., De Carlis, L., Baccarani, U., Ettorre, G. M., Cillo, U., Calise, F., Caccamo, L., Cuomo, O., Lupo, L., Corradini, S., Zamboni, F, Marianelli, T., Risaliti, A., Patrono, D., Petri, S. Li, Tagliabue, F., Mangoni, J. M.E., Antonelli, B., Sposito, C., Gringeri, E., Rompianesi, G., Sforza, D., Cucchetti, A., Miglioresi, L., Donataccio, M., Gelli, M., Gavrila, C., Nardi, A., and Angelico, M.

Published
2012

11. Survival after the diagnosis of de novo malignancy in liver transplant recipients

Author

Taborelli, M, Piselli, P, Ettorre, Gm, Baccarani, U, Burra, P, Lauro, A, Galatioto, L, Rendina, M, Shalaby, S, Petrara, R, Nudo, F, Toti, L, Fantola, G, Cimaglia, C, Agresta, A, Vennarecci, G, Pinna, Ad, Gruttadauria, S, Risaliti, A, Di Leo, A, Rossi, M, Tisone, G, Zamboni, F, Serraino, D, Zanus, G, Zanini, S, Rigotti, P, Schena, Fp, Grandaliano, G, Fiorentino, M, Di Gioia, P, Pellegrini, S, Zanfi, C, Scolari, Mp, Stefoni, S, Todeschini, P, Panicali, L, Valentini, C, Adani, Gl, Lorenzin, D, Colasanti, M, Coco, M, Ettorre, F, Santoro, R, Miglioresi, L, Mennini, G, Casella, A, Fazzolari, L, Sforza, D, Iaria, G, Gazia, C, Belardi, C, D'Offizi, G, Comandini, Uv, Lionetti, R, Montalbano, M, Taibi, C, Piredda, Gb, Michittu, Mb, Murgia, Mg, Onano, B, Fratino, L, Maso, Ld, De Paoli, P, Verdirosi, D, Vaccher, E, Pisani, F, Famulari, A, Delreno, F, Iesari, S, De Luca, L, Iaria, M, Capocasale, E, Cremaschi, E, Sandrini, S, Valerio, F, Mazzucotelli, V, Bossini, N, Setti, G, Veroux, M, Veroux, P, Giuffrida, G, Giaquinta, A, Zerbo, D, Busnach, G, Di Leo, L, Perrino, Ml, Querques, M, Colombo, V, Sghirlanzoni, Mc, Messa, P, Leoni, A, Sparacino, V, Caputo, F, Buscemi, B, Citterio, F, Spagnoletti, G, Salerno, Mp, Favi, E, Segoloni, Gp, Biancone, L, Lavacca, A, Maresca, Mc, Cascone, C, Virgilio, B, Donati, D, Dossi, F, Fontanella, A, Ambrosini, A, and Di Cicco, M.

Published
2019

12. HCV NS3 sequencing as a reliable and clinically useful tool for the assessment of genotype and resistance mutations for clinical samples with different HCV-RNA levels

Author

Di Maio, V C, Cento, V, Di Paolo, D, Aragri, M, De Leonardis, F, Tontodonati, M, Micheli, V, Bellocchi, M C, Antonucci, F P, Bertoli, A, Lenci, I, Milana, M, Gianserra, L, Melis, M, Di Biagio, A, Sarrecchia, C, Sarmati, L, Landonio, S, Francioso, S, Lambiase, L, Nicolini, L A, Marenco, S, Nosotti, L, Giannelli, V, Siciliano, M, Romagnoli, D, Pellicelli, A, Vecchiet, J, Magni, C F, Babudieri, S, Mura, M S, Taliani, G, Mastroianni, C, Vespasiani-Gentilucci, U, Romano, M, Morisco, F, Gasbarrini, A, Vullo, V, Bruno, S, Baiguera, C, Pasquazzi, C, Tisone, G, Picciotto, A, Andreoni, M, Parruti, G, Rizzardini, G, Angelico, M, Perno, C F, Ceccherini-Silberstein, F, Collaborators (129) Mariani R, HCV Italian Resistance Network Study Group., Paoloni, M, Iapadre, N, Grimaldi, A, Menzaghi, B, Quirino, T, Bruzzone, B, De Maria, A, Nicolini, La, Viscoli, C, Casinelli, K, Monache, Md, Lichtner, M, Aghemo, A, Cerrone, M, Colombo, M, Monforte, Ad, Danieli, E, Donato, F, Gubertini, G, Magni, Cf, Mancon, A, Monico, S, Niero, F, Puoti, M, Russo, Ml, Alfieri, R, Gnocchi, M, Orro, A, Milanesi, L, Baldelli, E, Bertolotti, M, Borghi, V, Mussini, C, Brancaccio, G, Caporaso, N, Gaeta, Gb, Lembo, V, Calvaruso, V, Craxì, A, Di Marco, V, Mazzola, A, Petta, S, D'Amico, E, Cacciatore, P, Consorte, A, Palitti, Vp, Pieri, A, Polilli, E, Antenucci, F, Antonucci, Fp, Armenia, D, Baiocchi, L, Bellocchi, M, Biliotti, E, Biolato, M, Carioti, L, Cerasari, G, Cerva, C, Ciotti, M, D'Ambrosio, C, D'Ettorre, G, De Sanctis, A, Di Maio VC, Furlan, C, Gallo, P, Grieco, A, Grieco, S, Lattanzi, B, Malagnino, V, Manuelli, M, Merli, M, Miglioresi, L, Palazzo, D, Perno, Cf, Santopaolo, F, Santoro, Mm, Sforza, D, Sorbo, Mc, Spaziante, M, Svicher, V, Teti, E, Mangia, A, Maida, I, Mura, Ms, Falconi, L, Di Giammartino, D, Tarquini, P., Di Maio, V C, Cento, V, Di Paolo, D, Aragri, M, De Leonardis, F, Tontodonati, M, Micheli, V, Bellocchi, M C, Antonucci, F P, Bertoli, A, Lenci, I, Milana, M, Gianserra, L, Melis, M, Di Biagio, A, Sarrecchia, C, Sarmati, L, Landonio, S, Francioso, S, Lambiase, L, Nicolini, L A, Marenco, S, Nosotti, L, Giannelli, V, Siciliano, M, Romagnoli, D, Pellicelli, A, Vecchiet, J, Magni, C F, Babudieri, S, Mura, M S, Taliani, G, Mastroianni, C, Vespasiani-Gentilucci, U, Romano, M, Morisco, F, Gasbarrini, A, Vullo, V, Bruno, S, Baiguera, C, Pasquazzi, C, Tisone, G, Picciotto, A, Andreoni, M, Parruti, G, Rizzardini, G, Angelico, M, Perno, C F, Ceccherini-Silberstein, F, HCV Italian Resistance Network Study Group., Collaborators (129) Mariani R, Paoloni, M, Iapadre, N, Grimaldi, A, Menzaghi, B, Quirino, T, Bruzzone, B, De Maria, A, Nicolini, La, Viscoli, C, Casinelli, K, Monache, Md, Lichtner, M, Aghemo, A, Cerrone, M, Colombo, M, Monforte, Ad, Danieli, E, Donato, F, Gubertini, G, Magni, Cf, Mancon, A, Monico, S, Niero, F, Puoti, M, Russo, Ml, Alfieri, R, Gnocchi, M, Orro, A, Milanesi, L, Baldelli, E, Bertolotti, M, Borghi, V, Mussini, C, Brancaccio, G, Caporaso, N, Gaeta, Gb, Lembo, V, Calvaruso, V, Craxì, A, Di Marco, V, Mazzola, A, Petta, S, D'Amico, E, Cacciatore, P, Consorte, A, Palitti, Vp, Pieri, A, Polilli, E, Antenucci, F, Antonucci, Fp, Armenia, D, Baiocchi, L, Bellocchi, M, Biliotti, E, Biolato, M, Carioti, L, Cerasari, G, Cerva, C, Ciotti, M, D'Ambrosio, C, D'Ettorre, G, De Sanctis, A, Di Maio, Vc, Furlan, C, Gallo, P, Grieco, A, Grieco, S, Lattanzi, B, Malagnino, V, Manuelli, M, Merli, M, Miglioresi, L, Palazzo, D, Perno, Cf, Santopaolo, F, Santoro, Mm, Sforza, D, Sorbo, Mc, Spaziante, M, Svicher, V, Teti, E, Mangia, A, Maida, I, Mura, M, Falconi, L, Di Giammartino, D, Tarquini, P., Di Maio, V. C, Bellocchi, M. C, Antonucci, F. P, Nicolini, L. A, Magni, C. F, Mura, M. S, Vespasiani Gentilucci, U, Morisco, Filomena, Perno, C. F, Ceccherini Silberstein, F., Caporaso, Nicola, Di Maio, V., Cento, V., Di Paolo, D., Aragri, M., De Leonardis, F., Tontodonati, M., Micheli, V., Bellocchi, M., Antonucci, F., Bertoli, A., Lenci, I., Milana, M., Gianserra, L., Melis, M., Di Biagio, A., Sarrecchia, C., Sarmati, L., Landonio, S., Francioso, S., Lambiase, L., Nicolini, L., Marenco, S., Nosotti, L., Giannelli, V., Siciliano, M., Romagnoli, D., Pellicelli, A., Vecchiet, J., Magni, C., Babudieri, S., Mura, M., Taliani, G., Mastroianni, C., Vespasiani-Gentilucci, U., Romano, M., Morisco, F., Gasbarrini, A., Vullo, V., Bruno, S., Baiguera, C., Pasquazzi, C., Tisone, G., Picciotto, A., Andreoni, M., Parruti, G., Rizzardini, G., Angelico, M., Perno, C., Ceccherini-Silberstein, F., Mariani, R., Paoloni, M., Iapadre, N., Grimaldi, A., Menzaghi, B., Quirino, T., Bruzzone, B., De Maria, A., Viscoli, C., Casinelli, K., Delle Monache, M., Lichtner, M., Aghemo, A., Cerrone, M., Colombo, M., D'Arminio Monforte, A., Danieli, E., Donato, F., Gubertini, G., Mancon, A., Monico, S., Niero, F., Puoti, M., Russo, M., Alfieri, R., Gnocchi, M., Orro, A., Milanesi, L., Baldelli, E., Bertolotti, M., Borghi, V., Mussini, C., Brancaccio, G., Caporaso, N., Gaeta, G., Lembo, V., Calvaruso, V., Craxã­, A., DI MARCO, V., Mazzola, A., Petta, S., D'Amico, E., Cacciatore, P., Consorte, A., Pace Palitti, V., Pieri, A., Polilli, E., Antenucci, F., Armenia, D., Baiocchi, L., Biliotti, E., Biolato, M., Carioti, L., Cerasari, G., Cerva, C., Ciotti, M., D'Ambrosio, C., D'Ettorre, G., De Sanctis, A., Furlan, C., Gallo, P., Grieco, A., Grieco, S., Lattanzi, B., Malagnino, V., Manuelli, M., Merli, M., Miglioresi, L., Palazzo, D., Santopaolo, F., Santoro, M., Sforza, D., Sorbo, M., Spaziante, M., Svicher, V., Teti, E., Mangia, A., Maida, I., Falconi, L., and Di Giammartino, D.

Subjects
0301 basic medicine, ns3, Genotyping Techniques, viruses, Drug Resistance, Hepacivirus, Viral Nonstructural Proteins, medicine.disease_cause, Gastroenterology, Telaprevir, chemistry.chemical_compound, genotype, genotyping techniques, hepacivirus, hepatitis C, humans, RNA viral, retrospective studies, sequence analysis, DNA, viral nonstructural proteins, drug resistance, viral, mutation, pharmacology, infectious diseases, 0302 clinical medicine, Retrospective Studie, Genotype, Pharmacology (medical), Viral, Hepatitis C, Humans, RNA, Viral, Retrospective Studies, Sequence Analysis, DNA, Drug Resistance, Viral, Mutation, Proteolytic enzymes, virus diseases, Settore MED/07 - Microbiologia e Microbiologia Clinica, hcv-rna levels, Infectious Diseases, HCV-RNA, 030211 gastroenterology & hepatology, Sequence Analysis, medicine.drug, Human, Microbiology (medical), medicine.medical_specialty, Hepatitis C virus, Concordance, Settore MED/12 - GASTROENTEROLOGIA, Pharmacology, Biology, 03 medical and health sciences, Boceprevir, Internal medicine, medicine, hcv, Genotyping, Hepaciviru, Viral Nonstructural Protein, Settore MED/09 - MEDICINA INTERNA, Virology, digestive system diseases, 030104 developmental biology, chemistry, Sequence Analysi, RNA, Genotyping Technique
Abstract

OBJECTIVES: This study aims to evaluate the reliability and clinical utility of NS3 sequencing in hepatitis C virus (HCV) 1-infected patients who were candidates to start a PI-containing regimen. METHODS: NS3 protease sequencing was performed by in-house-developed HCV-1 subtype-specific protocols. Phylogenetic analysis was used to test sequencing reliability and concordance with previous genotype/subtype assignment by commercial genotyping assays. RESULTS: Five hundred and sixty-seven HCV plasma samples with quantifiable HCV-RNA from 326 HCV-infected patients were collected between 2011 and 2014. Overall, the success rate of NS3 sequencing was 88.9%. The success rate between the two subtype protocols (HCV-1a/HCV-1b) was similarly high for samples with HCV-RNA >3 log IU/mL (>92% success rate), while it was slightly lower for HCV-1a samples with HCV-RNA ≤3 log IU/mL compared with HCV-1b samples. Phylogenetic analysis confirmed the genotype/subtype given by commercial genotyping assays in 92.9% (303/326) of cases analysed. In the remaining 23 cases (7.1%), 1 was HCV-1g (previously defined as subtype 1a), 1 was HCV-4d (previously defined as genotype 1b) and 1 was HCV-1b (previously defined as genotype 2a/2c). In the other cases, NS3 sequencing precisely resolved the either previous undetermined/discordant subtype 1 or double genotype/subtype assignment by commercial genotyping assays. Resistance-associated variants (RAVs) to PI were detected in 31.0% of samples. This prevalence changed according to PI experience (17.1% in PI-naive patients versus 79.2% in boceprevir/telaprevir/simeprevir-failing patients). Among 96 patients with available virological outcome following boceprevir/telaprevir treatment, a trend of association between baseline NS3 RAVs and virological failure was observed (particularly for HCV-1a-infected patients: 3/21 failing patients versus 0/22 achieving sustained virological response; P = 0.11). CONCLUSIONS: HCV-NS3 sequencing provides reliable results and at the same time gives two clinically relevant pieces of information: a correct subtype/genotype assignment and the detection of variants that may interfere with the efficacy of PI.

Published
2016

13. Multiclass HCV resistance to direct-acting antiviral failure in real-life patients advocates for tailored second-line therapies

Author

Di Maio, Velia C., Cento, Valeria, Lenci, Ilaria, Aragri, Marianna, Rossi, Piera, Barbaliscia, Silvia, Melis, Michela, Verucchi, Gabriella, Magni, Carlo F., Teti, Elisabetta, Bertoli, Ada, Antonucci, Francescopaolo, Bellocchi, Maria C., Micheli, Valeria, Masetti, Chiara, Landonio, Simona, Francioso, Simona, Santopaolo, Francesco, Pellicelli, Adriano M., Calvaruso, Vincenza, Gianserra, Laura, Siciliano, Massimo, Romagnoli, Dante, Cozzolongo, Raffaele, Grieco, Antonio, Vecchiet, Jacopo, Morisco, Filomena, Merli, Manuela, Brancaccio, Giuseppina, Di Biagio, Antonio, Loggi, Elisabetta, Mastroianni, Claudio Maria, Pace Palitti, Valeria, Tarquini, Pierluigi, Puoti, Massimo, Taliani, Gloria, Sarmati, Loredana, Picciotto, Antonino, Vullo, Vincenzo, Caporaso, Nicola, Paoloni, Maurizio, Pasquazzi, Caterina, Rizzardini, Giuliano, Parruti, Giustino, Craxì, Antonio, Babudieri, Sergio, Andreoni, Massimo, Angelico, Mario, Perno, Carlo F., Ceccherini Silberstein, Francesca, Mariani, R., Iapadre, N., Grimaldi, A., Cozzolongo, R., Andreone, P., Verucchi, G., Menzaghi, B., Quirino, T., Pisani, V., Torti, MARIA CHIARA, Vecchiet, J., Bruzzone, B., De Maria, A., Marenco, S., Nicolini, L. A., Viscoli, C., Casinelli, K., Delle Monache, M., Lichtner, Miriam, Aghemo, A., Boccaccio, V., Bruno, S., Cerrone, M., Colombo, M., D'Arminio Monforte, A., Danieli, E., Donato, F., Gubertini, G., Lleo, A., Magni, C. F., Mancon, A., Monico, S., Niero, F., Russo, M. L., Gnocchi, M., Orro, A., Milanesi, L., Baldelli, E., Bertolotti, M., Borghi, V., Mussini, C., Brancaccio, G., Gaeta, G. B., Lembo, V., Sangiovanni, V., Di Marco, V., Mazzola, A., Petta, S., D'Amico, E., Cacciatore, P., Consorte, A., Pieri, A., Polilli, E., Sozio, F., Antenucci, F., Aragri, M., Baiocchi, L., Barbaliscia, S., Biliotti, Elisa, Biolato, M., Carioti, L., Ceccherini Silberstein, F., Cerasari, G., Cerva, C., Ciotti, M., D'Ambrosio, C., D'Ettorre, G., De Leonardis, F., De Sanctis, A., Di Maio, V. C., Di Paolo, D., Furlan, Caterina, Gallo, P., Gasbarrini, A., Giannelli, V., Grieco, S., Lambiase, L., Lattanzi, B., Lenci, I., Lula, R., Malagnino, V., Manuelli, M., Miglioresi, L., Milana, M., Moretti, A., Nosotti, L., Palazzo, Donatella, Pellicelli, A., Romano, M., Sarrecchia, C., Sforza, D., Sorbo, M. C., Spaziante, M., Svicher, V., Tisone, G., Vespasiani Gentilucci, U., D'Adamo, G., Mangia, A., Maida, I., Mura, M. S., Falconi, L., Di Giammartino, D., Di Maio, V., Cento, V., Lenci, I., Aragri, M., Rossi, P., Barbaliscia, S., Melis, M., Verucchi, G., Magni, C., Teti, E., Bertoli, A., Antonucci, F., Bellocchi, M., Micheli, V., Masetti, C., Landonio, S., Francioso, S., Santopaolo, F., Pellicelli, A., Calvaruso, V., Gianserra, L., Siciliano, M., Romagnoli, D., Cozzolongo, R., Grieco, A., Vecchiet, J., Morisco, F., Merli, M., Brancaccio, G., Di Biagio, A., Loggi, E., Mastroianni, C., Pace Palitti, V., Tarquini, P., Puoti, M., Taliani, G., Sarmati, L., Picciotto, A., Vullo, V., Caporaso, N., Paoloni, M., Pasquazzi, C., Rizzardini, G., Parruti, G., Craxã¬, A., Babudieri, S., Andreoni, M., Angelico, M., Perno, C., Ceccherini-Silberstein, F., Mariani, R., Iapadre, N., Grimaldi, A., Andreone, P., Menzaghi, B., Quirino, T., Pisani, V., Torti, C., Bruzzone, B., De Maria, A., Marenco, S., Nicolini, L., Viscoli, C., Casinelli, K., Delle Monache, M., Lichtner, M., Aghemo, A., Boccaccio, V., Bruno, S., Cerrone, M., Colombo, M., D'Arminio Monforte, A., Danieli, E., Donato, F., Gubertini, G., Lleo, A., Mancon, A., Monico, S., Niero, F., Russo, M., Gnocchi, M., Orro, A., Milanesi, L., Baldelli, E., Bertolotti, M., Borghi, V., Mussini, C., Gaeta, G., Lembo, V., Sangiovanni, V., DI MARCO, V., Mazzola, A., Petta, S., D'Amico, E., Cacciatore, P., Consorte, A., Pieri, A., Polilli, E., Sozio, F., Antenucci, F., Baiocchi, L., Biliotti, E., Biolato, M., Carioti, L., Cerasari, G., Cerva, C., Ciotti, M., D'Ambrosio, C., D'Ettorre, G., De Leonardis, F., De Sanctis, A., Di Paolo, D., Furlan, C., Gallo, P., Gasbarrini, A., Giannelli, V., Grieco, S., Lambiase, L., Lattanzi, B., Lula, R., Malagnino, V., Manuelli, M., Miglioresi, L., Milana, M., Moretti, A., Nosotti, L., Palazzo, D., Romano, M., Sarrecchia, C., Sforza, D., Sorbo, M., Spaziante, M., Svicher, V., Tisone, G., Vespasiani-Gentilucci, U., D'Adamo, G., Mangia, A., Maida, I., Mura, M., Falconi, L., Di Giammartino, D., Di Maio, V, Cento, V, Lenci, I, Aragri, M, Rossi, P, Barbaliscia, S, Melis, M, Verucchi, G, Magni, C, Teti, E, Bertoli, A, Antonucci, F, Bellocchi, M, Micheli, V, Masetti, C, Landonio, S, Francioso, S, Santopaolo, F, Pellicelli, A, Calvaruso, V, Gianserra, L, Siciliano, M, Romagnoli, D, Cozzolongo, R, Grieco, A, Morisco, F, Merli, M, Brancaccio, G, Di Biagio, A, Loggi, E, Mastroianni, C, Pace Palitti, V, Tarquini, P, Puoti, M, Taliani, G, Sarmati, L, Picciotto, A, Vullo, V, Caporaso, N, Paoloni, M, Pasquazzi, C, Rizzardini, G, Parruti, G, Craxì, A, Babudieri, S, Andreoni, M, Angelico, M, Perno, C, Ceccherini-Silberstein, F, Velia C. Di Maio, Valeria Cento, Ilaria Lenci, Marianna Aragri, Piera Rossi, Silvia Barbaliscia, Michela Meli, Gabriella Verucchi, Carlo F. Magni, Elisabetta Teti, Ada Bertoli, Francesco Paolo Antonucci, Maria C. Bellocchi, Valeria Micheli, Chiara Masetti, Simona Landonio, Simona Francioso, Francesco Santopaolo, Adriano M. Pellicelli, Vincenza Calvaruso, Laura Gianserra, Massimo Siciliano, Dante Romagnoli, Raffaele Cozzolongo, Antonio Grieco, Jacopo Vecchiet, Filomena Morisco, Manuela Merli, Giuseppina Brancaccio, Antonio Di Biagio, Elisabetta Loggi, Claudio M. Mastroianni, Valeria Pace Palitti, Pierluigi Tarquini, Massimo Puoti, Gloria Taliani, Loredana Sarmati, Antonino Picciotto, Vincenzo Vullo, Nicola Caporaso, Maurizio Paoloni, Caterina Pasquazzi, Giuliano Rizzardini, Giustino Parruti, Antonio Craxì, Sergio Babudieri, Massimo Andreoni, Mario Angelico, Carlo F. Perno, Francesca Ceccherini-Silberstein, for the HCV Italian Resistance Network Study Group: [.., P. Andreone, E. Loggi, G. Verucchi, ], Di Maio, Velia C., Cento, Valeria, Lenci, Ilaria, Aragri, Marianna, Rossi, Piera, Barbaliscia, Silvia, Melis, Michela, Verucchi, Gabriella, Magni, Carlo F., Teti, Elisabetta, Bertoli, Ada, Antonucci, Francescopaolo, Bellocchi, Maria C., Micheli, Valeria, Masetti, Chiara, Landonio, Simona, Francioso, Simona, Santopaolo, Francesco, Pellicelli, Adriano M., Calvaruso, Vincenza, Gianserra, Laura, Siciliano, Massimo, Romagnoli, Dante, Cozzolongo, Raffaele, Grieco, Antonio, Vecchiet, Jacopo, Morisco, Filomena, Merli, Manuela, Brancaccio, Giuseppina, Di Biagio, Antonio, Loggi, Elisabetta, Mastroianni, Claudio M., Pace Palitti, Valeria, Tarquini, Pierluigi, Puoti, Massimo, Taliani, Gloria, Sarmati, Loredana, Picciotto, Antonino, Vullo, Vincenzo, Caporaso, Nicola, Paoloni, Maurizio, Pasquazzi, Caterina, Rizzardini, Giuliano, Parruti, Giustino, Craxã¬, Antonio, Babudieri, Sergio, Andreoni, Massimo, Angelico, Mario, Perno, Carlo F., Ceccherini-Silberstein, Francesca, Nicolini, L. A., Magni, C. F., Russo, M. L., Gaeta, G. B., Di Marco, V., Di Maio, V. C., Sorbo, M. C., Mura, M. S., Di Maio, Velia C, Magni, Carlo F, Bellocchi, Maria C, Pellicelli, Adriano M, Mastroianni, Claudio M, Craxì, Antonio, Perno, Carlo F, and Ceccherini Silberstein, Francesca

Subjects
Male, 0301 basic medicine, hepatitis C virus, Sustained Virologic Response, Sofosbuvir, Hepacivirus, Drug Resistance, resistance-associated substitutions, Viral Nonstructural Proteins, VARIANTS, NS5A, medicine.disease_cause, Gastroenterology, chemistry.chemical_compound, 0302 clinical medicine, Recurrence, INFECTION, antiviral therapy, Medicine, hepatitis C viru, Viral, Treatment Failure, Chronic, direct-acting antivirals, resistance test, hepatology, biology, GENOTYPE 1, virus diseases, Middle Aged, Settore MED/07 - Microbiologia e Microbiologia Clinica, Hepatitis C, Italy, Combination, Interferon, Drug Therapy, Combination, Female, 030211 gastroenterology & hepatology, Author Keywords:antiviral therapy, RIBAVIRIN, Sequence Analysis, Human, medicine.drug, medicine.medical_specialty, Daclatasvir, Genotype, Hepatitis C virus, Antiviral Agents, LONG-TERM PERSISTENCE, DACLATASVIR, 03 medical and health sciences, Drug Therapy, Aged, Drug Resistance, Viral, Hepatitis C, Chronic, Humans, Interferons, Mutation, Ribavirin, Sequence Analysis, DNA, Hepatology, TREATMENT-NAIVE, Internal medicine, Antiviral Agent, resistance-associated substitution, direct-acting antiviral, Hepaciviru, resistance test KeyWords Plus:HEPATITIS-C VIRUS, business.industry, Viral Nonstructural Protein, DNA, biology.organism_classification, Clinical trial, 030104 developmental biology, SOFOSBUVIR, chemistry, Sequence Analysi, Immunology, business
Abstract

Background & Aims: Despite the excellent efficacy of direct-acting antivirals (DAA) reported in clinical trials, virological failures can occur, often associated with the development of resistance-associated substitutions (RASs). This study aimed to characterize the presence of clinically relevant RASs to all classes in real-life DAA failures. Methods: Of the 200 virological failures that were analyzed in 197 DAA-treated patients, 89 with pegylated-interferon+ribavirin (PegIFN+RBV) and 111 without (HCV-1a/1b/1g/2/3/4=58/83/1/6/24/25; 56.8% treatment experienced; 65.5% cirrhotic) were observed. Sanger sequencing of NS3/NS5A/NS5B was performed by home-made protocols, at failure (N= 200) and whenever possible at baseline (N= 70). Results: The majority of the virological failures were relapsers (57.0%), 22.5% breakthroughs, 20.5% non-responders. RAS prevalence varied according to IFN/RBV use, DAA class, failure type and HCV genotype/subtype. It was 73.0% in IFN group vs 49.5% in IFN free, with the highest prevalence of NS5A-RASs (96.1%), compared to NS3-RASs (75.9% with IFN, 70.5% without) and NS5B-RASs (66.6% with IFN, 20.4% without, in sofosbuvir failures). In the IFN-free group, RASs were higher in breakthrough/non-responders than in relapsers (90.5% vs 40.0%, P= 2 DAA classes showed multiclass resistance, including 11/11 NS3+NS5A failures. Furthermore, 20.0% of patients had baseline-RASs, which were always confirmed at failure. Conclusions: In our failure setting, RAS prevalence was remarkably high in all genes, with a partial exception for NS5B, whose limited resistance is still higher than previously reported. This multiclass resistance advocates for HCV resistance testing at failure, in all three genes for the best second-line therapeutic tailoring.

Published
2017

15. Treatment of genotype-1 hepatitis C recurrence after liver transplant improves survival in both sustained responders and relapsers

Author

Ponziani FR, Milani A, Gasbarrini A, Zaccaria R, Viganò R, Iemmolo RM, Donato MF, Rendina M, Toniutto P, Pasulo L, CESCON, MATTEO, Burra P, Miglioresi L, Merli M, Paolo DD, Fagiuoli S, Pompili M, AISF RECOLT C. Group, Ponziani FR, Milani A, Gasbarrini A, Zaccaria R, Viganò R, Iemmolo RM, Donato MF, Rendina M, Toniutto P, Pasulo L, Cescon M, Burra P, Miglioresi L, Merli M, Paolo DD, Fagiuoli S, Pompili M, AISF RECOLT-C Group, Ponziani, F, Milani, A, Gasbarrini, A, Zaccaria, R, Viganò, R, Iemmolo, R, Donato, M, Rendina, M, Toniutto, P, Pasulo, L, Cescon, M, Burra, P, Miglioresi, L, Merli, M, Paolo, D, Fagiuoli, S, and Pompili, M

Subjects
Graft Rejection, Male, hepatitis C virus, pegylated interferon, ribavirin, liver transplant, survival, hepatitis c recurrence, antiviral treatment, responders, hepatitis c virus, genotype-1, medicine.medical_treatment, hepatitis C recurrence, Kaplan-Meier Estimate, Liver transplantation, Gastroenterology, Polyethylene Glycols, Cohort Studies, chemistry.chemical_compound, Pegylated interferon, Recurrence, Hepatitis C, liver transplantation, hepatitis C viru, Chronic, medicine.diagnostic_test, Graft Survival, Middle Aged, Recombinant Proteins, Treatment Outcome, Italy, Liver biopsy, Retreatment, Regression Analysis, Female, Drug, medicine.drug, medicine.medical_specialty, Genotype, Settore MED/12 - GASTROENTEROLOGIA, responder, Alpha interferon, antiviral treatment, genotype-1, hepatitis C recurrence, hepatitis C virus , liver transplant, pegylated interferon, ribavirin, responders, survival, Antiviral Agents, Risk Assessment, Drug Administration Schedule, Viral Relapse, Dose-Response Relationship, Predictive Value of Tests, Internal medicine, medicine, Humans, Survival analysis, Retrospective Studies, Transplantation, Dose-Response Relationship, Drug, business.industry, Ribavirin, Settore MED/09 - MEDICINA INTERNA, Interferon-alpha, Hepatitis C, Chronic, medicine.disease, Survival Analysis, Surgery, Liver Transplantation, chemistry, Multivariate Analysis, business, Follow-Up Studies
Abstract

Summary The aim of this study was to evaluate the factors affecting the response to treatment and how it could affect survival in a large series of genotype-1 HCV-transplanted patients. Three-hundred and twenty six genotype-1 HCV patients were enrolled. One hundred and ninety-six patients (60.1%) were nonresponders and 130 (39.9%) showed negative HCV-RNA at the end of treatment. Eighty-four of them (25.8%) achieved sustained virological response, while 46 (14.1%) showed viral relapse. Five-year cumulative survival was significantly worse in nonresponders (76.4%) compared with sustained viral response (93.2) or relapsers (94.9%). Sustained responders and relapsers were therefore considered as a single ‘response group’ in further analysis. Pretreatment variables significantly associated with virological response at multivariate regression analysis were the absence of ineffective pretransplant antiviral therapy, the recurrence of HCV-hepatitis more than 1 year after transplant, an histological grading 4 at pretreatment liver biopsy, a pretreatment HCV-RNA level

Published
2013

18. Treatment of hepatitis C recurrence is less successful in female than in male liver transplant recipients

Author

Giannelli, V, Giusto, M, Farcomeni, A, Ponziani, F, Pompili, M, Viganò, R, Iemmolo, R, Donato, M, Rendina, M, Toniutto, P, Pasulo, L, Morelli, M, De Martin, E, Miglioresi, L, DI PAOLO, D, Fagiuoli, S, Merli, M, Belli, L, Gerunda, G, Montalti, R, Di Benedetto, F, De Ruvo, N, Rigamonti, C, Colombo, M, Rossi, G, Fornasiere, E, Di Leo, A, Castellaneta, N, Lupo, L, Nemeo, V, Bringiotti, R, Zappimbulso, M, Vero, V, Colpani, M, Cescon, M, Bertuzzo, V, Pinna, A, Visco Comandini, U, Antonucci, G, Ettorre, G, Burra, P, Senzolo, M, Ginanni, C, Mennini, G, Rossi, M, Angelico, M, Tisone, G, Gasbarrini, A, Giannelli, V, Giusto, M, Farcomeni, A, Ponziani, F, Pompili, M, Viganò, R, Iemmolo, R, Donato, M, Rendina, M, Toniutto, P, Pasulo, L, Morelli, M, De Martin, E, Miglioresi, L, Di Paolo, D, Fagiuoli, S, Merli, M, Giannelli, Valerio, Giusto, Michela, Farcomeni, Alessio, Ponziani, Francesca R, Pompili, Maurizio, Viganò, Raffaella, Iemmolo, Rosa Maria, Donato, Maria F, Rendina, Maria, Toniutto, Pierluigi, Pasulo, Luisa, Morelli, Maria Cristina, De Martin, Eleonora, Miglioresi, Lucia, Di Paolo, Daniele, Fagiuoli, Stefano, Merli, Manuela, Montalti, Roberto, Giannelli V., Giusto M., Farcomeni A., Ponziani F.R., Pompili M., Viganò R., Iemmolo R.M., Donato M.F., Rendina M., Toniutto P., Pasulo L., Morelli M.C., De Martin E., Miglioresi L., Di Paolo D., Fagiuoli S., Merli M., Belli L., Gerunda G.E., Montalti R., Di Benedetto F., De Ruvo N., Rigamonti C., Colombo M., Rossi G., Fornasiere E., Di Leo A., Castellaneta N.M., Lupo L., Nemeo V., Bringiotti R., Zappimbulso M., Vero V., Colpani M., Cescon M., Bertuzzo V., Pinna A.D., Visco-Comandini U., Antonucci G., Ettorre G.M., Burra P., Senzolo M., Ginanni C.S., Mennini G., Rossi M., Angelico M., Tisone G., and Gasbarrini A.

Subjects
Adult, Male, antiviral treatment, Sex Factor, Hepacivirus, Polyethylene Glycol, Antiviral Agents, Settore MED/01 - Statistica Medica, Polyethylene Glycols, Sex Factors, INTERFERON THERAPY, Retrospective Studie, Recurrence, Ribavirin, gender, Humans, adherence, HCV, liver transplant, hepatitis c, Aged, Retrospective Studies, Antiviral Agent, Settore MED/12 - Gastroenterologia, Hepaciviru, liver transplantation, Settore MED/09 - MEDICINA INTERNA, HCV recurrence, liver transplantation, virus diseases, HEPATITIS C VIRUS, Interferon-alpha, Hepatitis C, Chronic, Middle Aged, Viral Load, hcv, hepatitis c virus, digestive system diseases, Liver Transplantation, Treatment Outcome, Patient Compliance, RNA, Viral, Female, HCV recurrence, Human
Abstract

It has been recently suggested that the risk of graft loss after liver transplantation (LT) may increase in female HCV patients. The aim of the study was to examine gender differences in HCV therapy tolerance and outcome in LT patients treated for HCV recurrence. A retrospective study was conducted on liver recipients with HCV recurrence, who were given antiviral therapy from 2001 to 2009 in 12 transplant centers in Italy. Sustained virological response (SVR), adherence-to-therapy, and side effects were evaluated. A multivariate logistic regression model was used after adjusting for possible confounders. The data regarding 342 treated patients were analyzed. SVR was reported in 38.8% of patients. At baseline, male and female did not differ in HCV viral load, histology, or rate of diabetes. SVR was lower in females than in males (29.5% vs. 42.1%; P=0.03). Adherence-to-therapy was also lower in females than in males 43.4% vs. 23.8%; P=0.001); anemia was the main reason for lower adherence. In a multivariate analysis in patients Genotype1, female gender (P

Published
2012

21. Worse Graft Survival in HCV-Infected Transplanted Females Receiving a Male Donor Graft. The Liver Match Study

Author

Romagnoli, R., Rossi, M., Gerunda, G. E., Pinna, A. D., Agnes, S., Marco Spada, Colledan, M., Tisone, G., Carlis, L., Baccarani, U., Ettorre, G. M., Cillo, U., Calise, F., Caccamo, L., Cuomo, O., Lupo, L., Corradini, S., Zamboni, F., Marianelli, T., Risaliti, A., Patrono, D., Petri, S. Li, Tagliabue, F., Mangoni, J. M. E., Antonelli, B., Sposito, C., Gringeri, E., Rompianesi, G., Sforza, D., Cucchetti, A., Miglioresi, L., Donataccio, M., Gelli, M., Gavrila, C., Nardi, A., Angelico, M., Romagnoli, R, Rossi, M, Gerunda, G, Pinna, A, Agnes, S, Spada, M, Colledan, M, Tisone, G, De Carlis, L, Baccarani, U, Ettorre, G, Cillo, U, Calise, F, Caccamo, L, Cuomo, O, Lupo, L, Corradini, S, Zamboni, F, Marianelli, T, Risaliti, A, Patrono, D, Petri, S, Tagliabue, F, Mangoni, J, Antonelli, B, Sposito, C, Gringeri, E, Rompianesi, G, Sforza, D, Cucchetti, A, Miglioresi, L, Donataccio, M, Gelli, M, Gavrila, C, Nardi, A, and Angelico, M

Subjects
HCV infection, liver transplantation, Transplantation, Hepatology, HCV-infected transplanted females, Gastroenterology, Surgery
Published
2012

22. The Persistence of HCV Replication Is Associated with an Increased Mortality Rate in HCV Recurrent Transplant Patients: Results from the AISF-RECOLT-C Group

Author

Rendina, M., Castellaneta, N. M., Fagiuoli, Stefano, Ponziani, F., Vigano, R., Iemmolo, R. M., Donato, M. F., Toniutto, P., Pasulo, L., Morelli, M. C., Burra, Patrizia, Miglioresi, L., Giannelli, V., Paolo, D. D., Leo, A. D., Rendina, M, Castellaneta, N, Fagiuoli, S, Ponziani, F, Vigano, R, Iemmolo, R, Donato, M, Toniutto, P, Pasulo, L, Morelli, M, Burra, P, Miglioresi, L, Giannelli, V, Paolo, D, and Leo, A

Subjects
HCV replication, mortality, transplant patients
Published
2011

23. Long-term maintenance of sustained virological response in liver transplant recipients treated for recurrent hepatitis C

Author

Ponziani, Fr, Viganò, R, Iemmolo, Rm, Donato, Mf, Rendina, M, Toniutto, P, Pasulo, L, Morelli, Mc, Burra, Patrizia, Miglioresi, L, Merli, M, Di Paolo, D, Fagiuoli, S, Gasbarrini, A, Pompili, M, Belli, L, Gerunda, Ge, Marino, M, Montalti, R, Di Benedetto, F, De Ruvo, N, Rigamonti, C, Colombo, M, Rossi, G, Di Leo, A, Lupo, L, Memeo, V, Bringiotti, R, Zappimbulso, M, Bitetto, D, Vero, V, Colpani, M, Fornasiere, E, Pinna, Ad, Bertuzzo, V, DE MARTIN, Eleonora, Senzolo, M, Ettorre, Gm, Visco Comandini, U, Antonucci, G, Angelico, M, Tisone, G, Giannelli, V, Giusto, M, Group, AISF RECOLT C., Ponziani, Francesca Romana, Viganò, Raffaella, Iemmolo, Rosa Maria, Donato, Maria Francesca, Rendina, Maria, Toniutto, Pierluigi, Pasulo, Luisa, Morelli, Maria Cristina, Burra, Patrizia, Miglioresi, Lucia, Merli, Manuela, Di Paolo, Daniele, Fagiuoli, Stefano, Gasbarrini, Antonio, Pompili, Maurizio, Belli, L, Gerunda, G E, Marino, M, Montalti, R, Di Benedetto, F, De Ruvo, N, Rigamonti, C, Colombo, M, Rossi, G, Di Leo, A, Lupo, L, Memeo, V, Bringiotti, R, Zappimbulso, M, Bitetto, D, Vero, V, Colpani, M, Fornasiere, E, Pinna, A D, Morelli, M C, Bertuzzo, V, De Martin, E, Senzolo, M, Ettorre, G M, Visco-Comandini, U, Antonucci, G, Angelico, M, Tisone, G, Giannelli, V, Giusto, M, Ponziani, F, Fagiuoli, S, Gasbarrini, A, Pompili, M, Francesca Romana Ponziani, Raffaella Viganò, Rosa Maria Iemmolo, Maria Francesca Donato, Maria Rendina, Pierluigi Toniutto, Luisa Pasulo, Maria Cristina Morelli, Patrizia Burra, Lucia Miglioresi, Manuela Merli, Daniele Di Paolo, Stefano Fagiuoli, Antonio Gasbarrini, Maurizio Pompili, L. Belli, G.E. Gerunda, M. Marino, R. Montalti, F. Di Benedetto, N. De Ruvo, C. Rigamonti, M. Colombo, G. Rossi, A. Di Leo, L. Lupo, V. Memeo, R. Bringiotti, M. Zappimbulso, D. Bitetto, V. Vero, M. Colpani, E. Fornasiere, A.D. Pinna, M.C. Morelli, V. Bertuzzo, E. De Martin, M. Senzolo, G.M. Ettorre, U. Visco-Comandini, G. Antonucci, M. Angelico, G. Tisone, V. Giannelli, and M. Giusto

Subjects
Male, Sustained viral response, Time Factors, medicine.medical_treatment, Hepacivirus, Liver transplantation, medicine.disease_cause, Gastroenterology, Polyethylene Glycol, Polyethylene Glycols, Virological response, HCV antiviral treatment, Recurrence, Retrospective Studie, antiviral therapy, Viral, Recurrent hepatitis, Chronic, hepatitis c, Univariate analysis, Graft Survival, Hepatitis C recurrence, Long term maintenance, Hepatitis C, Middle Aged, Recombinant Protein, Recombinant Proteins, Survival Rate, Combination, RNA, Viral, Drug Therapy, Combination, Female, Human, medicine.medical_specialty, Genotype, Time Factor, Hepatitis C virus, Settore MED/12 - GASTROENTEROLOGIA, Antiviral Agents, liver transplantation, hepatitis c recurrence, sustained viral response, hcv antiviral treatment, Follow-Up Studie, Maintenance Chemotherapy, Drug Therapy, Internal medicine, Ribavirin, medicine, Follow-Up Studies, Hepatitis C, Chronic, Humans, Interferon-alpha, Interleukins, Retrospective Studies, Liver Transplantation, Survival rate, Antiviral Agent, Hepaciviru, Hepatology, business.industry, Interleukin, medicine.disease, Immunology, HCV, virological response, liver transplant, RNA, Interferons, business
Abstract

Background The recurrence of hepatitis C viral infection is common after liver transplant, and achieving a sustained virological response to antiviral treatment is desirable for reducing the risk of graft loss and improving patients’ survival. Aim To investigate the long-term maintenance of sustained virological response in liver transplant recipients with hepatitis C recurrence. Methods 436 Liver transplant recipients (74.1% genotype 1) who underwent combined antiviral therapy for hepatitis C recurrence were retrospectively evaluated. Results The overall sustained virological response rate was 40% (173/436 patients), and the mean follow-up after liver transplantation was 11 ± 3.5 years (range, 5–24). Patients with a sustained virological response demonstrated a 5-year survival rate of 97% and a 10-year survival rate of 93%; all but 6 (3%) patients remained hepatitis C virus RNA-negative during follow-up. Genotype non-1 (p = 0.007), treatment duration >80% of the scheduled period (p = 0.027), and early virological response (p = 0.002), were associated with the maintenance of sustained virological response as indicated by univariate analysis. Early virological response was the only independent predictor of sustained virological response maintenance (p = 0.008). Conclusions Sustained virological response achieved after combined antiviral treatment is maintained in liver transplant patients with recurrent hepatitis C and is associated with an excellent 5-year survival.

Published
2014

25. Distribution of IL28B Polymorphism in a Cohort of Italians and Immigrants with HCV Infection: Association with Viraemia, Stage of Fibrosis and Response to Treatment

Author

Nosotti, L., primary, Petrelli, A., additional, Genovese, D., additional, Catone, S., additional, Argentini, C., additional, Vella, S., additional, Rossi, A., additional, Costanzo, G., additional, Fortino, A., additional, Chessa, L., additional, Miglioresi, L., additional, and Mirisola, C., additional

Published
2016
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27. Impact of different Sofosbuvir-based direct acting antiviral (DAA) regimen in elderly cirrhotic patients: A real world experience from CLEO Group

Author

Pellicelli, A.M., primary, Pace Palitti, V., additional, Vignally, P., additional, Moretti, A., additional, Tarquini, P., additional, Scifo, G., additional, Messina, V., additional, Ascione, A., additional, Izzi, A., additional, D’Ambrosio, C., additional, Villani, R., additional, Fondacaro, L., additional, Fontanella, L., additional, Guarascio, P., additional, Alessio, L., additional, Miglioresi, L., additional, D’amico, E., additional, Ettorre, G.M., additional, Marignani, M., additional, Begini, P., additional, Cerasari, G., additional, Barlattani, A., additional, Armignacco, O., additional, and Barbarini, G., additional

Published
2016
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29. Graft survival is worse in HCV positive females transplanted with male donor grafts

Author

Belli, L., Romagnoli, Renato, Rossi, M., Gerunda, Ge, Pinna, Ad, Agnes, S., Spada, M., Colledan, M., Tisone, G., Decarlis, L., Baccarani, U., Mazzaferro, V., Ettorre, Gm, Cillo, U., Calise, F., Cuomo, O., Lupo, L., Ginanni Corradini, S., Zamboni, F., Marianelli, T., Risaliti, A., Patrono, Damiano, Li Petri, S., Tagliabue, F., Jme, Mangoni, Antonelli, B., Sposito, C., Gringeri, E., Rompianesi, G., Sforza, D., Cucchetti, A., Miglioresi, L., Donataccio, M., Gelli, M., Gavrila, C., Nardi, A., and Angelico, M.

Subjects
HCV infection, liver transplantation
Published
2012

30. Graft survival is worse in HCV positive females transplanted with male donor grafts L

Author

Belli, Romagnoli, R., Rossi, M., Gerunda, G. E., Pinna, A. D., Agnes, S., Spada, M., Colledan, M., Tisone, G., De Carlis, L., Baccarani, U., Mazzaferro, V., Ettorre, G. M., Cillo, Umberto, Calise, F., Cuomo, O., Lupo, L., Ginanni Corradini, S., Zamboni, F., Marianelli, T., Risaliti, A., Patrono, D., Li Petri, S., Tagliabue, F., Mangoni, J. M. E., Antonelli, B., Sposito, C., Gringeri, Enrico, Rompianesi, G., Sforza, D., Cucchetti, A., Miglioresi, L., Donataccio, M., Gelli, M., Gavrila, C., Nardi, A., Angelico, M., Italian Liver Ctrs, for the Liver Match i. n. v. e. s. t. i. g. a. t. o. r. s., Italian Association for the Study of the Liver, Dept, Mathematics, Tor Vergata Univ, and Rome

Published
2012

40. Fibrosis Progression in Non Responders to Antiviral Treatment (AT) in HCV Recurrence Following Liver Transplantation (LT): An Italian Multicenter Retrospective Study

Author

DE MARTIN, Eleonora, Senzolo, Marco, Francesca, P. R., Pasulo, L., Vigano, R., Belli, L., Donato, F., Angelico, M., Paolo, D. D., Rendina, M., Miglioresi, L., Grazi, G. L., Morelli, M., Toniutto, P., Merli, M., Giannelli, V., Castellaneta, N. M., Marino, M., Iemmolo, R. M., Gerunda, G. E., Villa, E., Gasbarrini, A., Fagiuoli, S., and Burra, Patrizia

Published
2010

44. P885 RECIPIENT AND DONOR GENDER MATCH PREDICTS THE OUTCOME OF ANTIVIRAL THERAPY FOR RECURRENT HEPATITIS C

Author

Bitetto, D., primary, Pecere, S., additional, Pasulo, L., additional, Belli, L., additional, Iemmolo, R.M., additional, Morelli, M.C., additional, Donato, F., additional, Burra, P., additional, Rendina, M., additional, Ponziani, F.R., additional, Miglioresi, L., additional, Di Paolo, D., additional, Merli, M., additional, Gasbarrini, A., additional, Toniutto, P., additional, and Fagiuoli, S., additional

Published
2014
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46. The impact of IL-28B polymorphism and diabetes on SVR after antiviral therapy (AT) for post-liver transplant (LT) HCV recurrence

Author

Bitetto, D., primary, Vero, V., additional, Pecere, S., additional, Belli, L., additional, Iemmolo, R.M., additional, Morelli, M.C., additional, Donato, F., additional, Burra, P., additional, Rendina, M., additional, Ponziani, F.R., additional, Miglioresi, L., additional, Di Paolo, D., additional, Merli, M., additional, Gasbarrini, A., additional, Ginanni-Corradini, S., additional, Falleti, E., additional, De Feo, T., additional, Toniutto, P., additional, and Fagiuoli, S., additional

Published
2014
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47. Long term NUC treatment in hepatitis B virus HBeAg negative genotype D patients and risk for hepatocellular carcinoma: Evidence from the CLEO cohort study

Author

Pellicelli, A.M., primary, Vignally, P., additional, Barbarini, G., additional, Messina, V., additional, Izzi, A., additional, Mazzoni, E., additional, Romano, M., additional, Mecenate, F., additional, Barlattani, A., additional, Picardi, A., additional, Vespasiani Gentilucci, U., additional, D’ambrosio, C., additional, Fondacaro, L., additional, Miglioresi, L., additional, Telesca, C., additional, Cerasari, G., additional, Guarascio, P., additional, Andreoli, A., additional, Stroffolini, T., additional, Furlan, C., additional, Gulminetti, R., additional, Bonaventura, M.E., additional, and Bacca, D., additional

Published
2014
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48. Recipient and donor gender match predicts the outcome of antiviral therapy for recurrent hepatitis C

Author

Bitetto, D., primary, Pecere, S., additional, Pasulo, L., additional, Belli, L., additional, Iemmolo, R.M., additional, Morelli, M.C., additional, Donato, F., additional, Burra, P., additional, Rendina, M., additional, Ponziani, F.R., additional, Miglioresi, L., additional, Di Paolo, D., additional, Merli, M., additional, Gasbarrini, A., additional, Toniutto, P., additional, and Fagiuoli, S., additional

Published
2014
Full Text
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