1. Migraine improvement after spontaneous cervical artery dissection the Italian Project on Stroke in Young Adults (IPSYS)
- Author
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Filomena Caria, Corrado Lodigiani, Enrico Maria Lotti, Francesca Graziano, Elisa Giorli, Andrea Zini, Lucia Tancredi, Maurizio Paciaroni, Valeria Piras, Massimiliano Braga, Valeria De Giuli, Mario Grassi, Ilaria Casetta, Maria Luisa DeLodovici, Loris Poli, Simona Marcheselli, Laura Cucurachi, Alessandro Pezzini, Rosalba Patella, Alessandro Padovani, Alessandro Adami, Massimo Gamba, Carmela Casella, Alessia Giossi, Giorgio Silvestrelli, Marialuisa Zedde, De Giuli, V, Graziano, F, Zini, A, Zedde, M, Patella, R, Lodigiani, C, Marcheselli, S, Delodovici, M, Paciaroni, M, Casetta, I, Giorli, E, Adami, A, Braga, M, Casella, C, Giossi, A, Silvestrelli, G, Tancredi, L, Lotti, E, Poli, L, Caria, F, Piras, V, Cucurachi, L, Gamba, M, Grassi, M, Padovani, A, and Pezzini, A
- Subjects
Adult ,Male ,Migraine without Aura ,medicine.medical_specialty ,Neurology ,Aura ,Migraine with Aura ,Remission, Spontaneous ,LS5_11 ,Dermatology ,Cervical artery dissection ,Cervical artery dissection, Migraine, Stroke in young adults ,03 medical and health sciences ,Young Adult ,Economica ,Stroke in young adults ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Medicine ,Humans ,030212 general & internal medicine ,Young adult ,Stroke ,Migraine ,LS4_7 ,Vertebral Artery Dissection ,business.industry ,Migraine. Spontaneus cervical dissection ,General Medicine ,Pain scale ,Cerebral Infarction ,medicine.disease ,Migraine with aura ,Stroke in young ,Psychiatry and Mental health ,adults Migraine ,Italy ,Case-Control Studies ,Female ,Neurology (clinical) ,medicine.symptom ,Headaches ,business ,030217 neurology & neurosurgery - Abstract
Objective: Whether migraine modifies after spontaneous cervical artery dissection (sCeAD) more than after other stroke etiologic subtypes has never been adequately investigated. Methods: In the setting of the Italian Project on Stroke in Young Adults (IPSYS), we compared the course of migraine before and after acute brain infarct in a group of migraine patients with sCeAD and a group of migraine patients whose ischemia was due to a cause other than CeAD (non-CeAD IS), matched by sex, age (± 3 years), and migraine subtype.We applied linear mixed models to evaluate pre-event vs post-event changes and differences between sCeAD and non-CeAD IS patients. Results: Eighty-seven patients per group (migraine without aura/migraine with aura, 67/20) qualified for the analysis. After the acute event, migraine headaches disappeared in 14.0% of CeAD patients vs 0.0% of non-CeAD IS patients (p ≤ 0.001). Migraine frequency (patients suffering at least 1 attack, from 93.1 to 80.5%, p = 0.001), pain intensity (from 6.7 ± 1.7 to 4.6 ± 2.6 in a 0 to 10 pain scale, p ≤ 0.001), and use of acute anti-migraine medications (patients taking at least 1 preparation, from 81.6 to 64.4%, p = 0.007) also improved significantly after CeAD as opposed to that observed after non-CeAD IS. Conclusion: The spontaneous improvement of migraine after sCeAD reinforces the hypothesis of a pathogenic link between the two conditions
- Published
- 2019