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16 results on '"Mikhaylenko, Dmitry S."'

3. Parental Origin of the RB1 Gene Mutations in Families with Low Penetrance Hereditary Retinoblastoma

Author

Alekseeva, Ekaterina A., primary, Babenko, Olga V., additional, Kozlova, Valentina M., additional, Ushakova, Tatiana L., additional, Kazubskaya, Tatiana P., additional, Nemtsova, Marina V., additional, Chesnokova, Galina G., additional, Mikhaylenko, Dmitry S., additional, Bure, Irina V., additional, Kalinkin, Alexey I., additional, Kuznetsova, Ekaterina B., additional, Tanas, Alexander S., additional, Kutsev, Sergey I., additional, Zaletaev, Dmitry V., additional, and Strelnikov, Vladimir V., additional

Published
2021
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4. Mutations in Epigenetic Regulation Genes in Gastric Cancer

Author

Nemtsova, Marina V., primary, Kalinkin, Alexey I., additional, Kuznetsova, Ekaterina B., additional, Bure, Irina V., additional, Alekseeva, Ekaterina A., additional, Bykov, Igor I., additional, Khorobrykh, Tatiana V., additional, Mikhaylenko, Dmitry S., additional, Tanas, Alexander S., additional, and Strelnikov, Vladimir V., additional

Published
2021
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5. Comprehensive Molecular Genetic Diagnostics of Birt-Hogg-Dube Syndrome in a Russian Patient with Renal Cancer and Lung Cysts: A Case Report

Author

Mikhaylenko, Dmitry S., primary, Matveev, Vsevolod B., additional, Filippova, Margarita G., additional, Anoshkin, Kirill I., additional, Kozlov, Nikolay A., additional, Khachaturyan, Alexander V., additional, Semyanikhina, Alexandra V., additional, Nifatov, Sergey D., additional, Tanas, Alexander S., additional, Nemtsova, Marina V., additional, and Zaletayev, Dmitry V., additional

Published
2021
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7. Secretion of Mutant DNA and mRNA by the Exosomes of Breast Cancer Cells

Author

Andreeva, Olga E., primary, Shchegolev, Yuri Y., additional, Scherbakov, Alexander M., additional, Mikhaevich, Ekaterina I., additional, Sorokin, Danila V., additional, Gudkova, Margarita V., additional, Bure, Irina V., additional, Kuznetsova, Ekaterina B., additional, Mikhaylenko, Dmitry S., additional, Nemtsova, Marina V., additional, Bagrov, Dmitry V., additional, and Krasil’nikov, Mikhail A., additional

Published
2021
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8. Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3′-diindolylmethane and chemotherapy drugs

Author

Nikulin, Sergey V., primary, Alekseev, Boris Ya., additional, Sergeeva, Nataliya S., additional, Karalkin, Pavel A., additional, Nezhurina, Elizaveta K., additional, Kirsanova, Valentina A., additional, Sviridova, Irina K., additional, Akhmedova, Suraja A., additional, Volchenko, Nadezhda N., additional, Bolotina, Larisa V., additional, Osipyants, Andrey I., additional, Hushpulian, Dmitry M., additional, Topchiy, Maxim A., additional, Asachenko, Andrey F., additional, Koval, Anastasia P., additional, Shcherbo, Dmitry S., additional, Kiselev, Vsevolod I., additional, Mikhaylenko, Dmitry S., additional, Schumacher, Udo, additional, and Poloznikov, Andrey A., additional

Published
2020
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9. Application Areas of Traditional Molecular Genetic Methods and NGS in relation to Hereditary Urological Cancer Diagnosis

Author

Mikhaylenko, Dmitry S., Tanas, Alexander S., Zaletaev, Dmitry V., and Nemtsova, Marina V.

Subjects
Article Subject
Abstract

Next generation sequencing (NGS) is widely used for diagnosing hereditary cancer syndromes. Often, exome sequencing and extended gene panel approaches are the only means that can be used to detect a pathogenic germline mutation in the case of multiple primary tumors, early onset, a family history of cancer, or a lack of specific signs associated with a particular syndrome. Certain germline mutations of oncogenes and tumor suppressor genes that determine specific clinical phenotypes may occur in mutation hot spots. Diagnosis of such cases, which involve hereditary cancer, does not require NGS, but may be made using PCR and Sanger sequencing. Diagnostic criteria and professional community guidelines developed for hereditary cancers of particular organs should be followed when ordering molecular diagnostic tests for a patient. This review focuses on urological oncology associated with germline mutations. Clinical signs and genetic diagnostic laboratory tests for hereditary forms of renal cell cancer, prostate cancer, and bladder cancer are summarized. While exome sequencing, or, conversely, traditional molecular genetic methods are the procedure of choice in some cases, in most situations, sequencing of multigene panels that are specifically aimed at detecting germline mutations in early onset renal cancer, prostate cancer, and bladder cancer seems to be the basic solution for molecular genetic diagnosis of hereditary cancers.

Published
2020
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11. Genetic Polymorphisms Associated with Rheumatoid Arthritis Development and Antirheumatic Therapy Response

Author

Mikhaylenko, Dmitry S., primary, Nemtsova, Marina V., additional, Bure, Irina V., additional, Kuznetsova, Ekaterina B., additional, Alekseeva, Ekaterina A., additional, Tarasov, Vadim V., additional, Lukashev, Alexander N., additional, Beloukhova, Marina I., additional, Deviatkin, Andrei A., additional, and Zamyatnin, Andrey A., additional

Published
2020
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13. Differentially Expressed Genes Associated With Prognosis in Locally Advanced Lymph Node-Negative Prostate Cancer

Author

Pudova, Elena A., primary, Lukyanova, Elena N., additional, Nyushko, Kirill M., additional, Mikhaylenko, Dmitry S., additional, Zaretsky, Andrew R., additional, Snezhkina, Anastasiya V., additional, Savvateeva, Maria V., additional, Kobelyatskaya, Anastasiya A., additional, Melnikova, Nataliya V., additional, Volchenko, Nadezhda N., additional, Efremov, Gennady D., additional, Klimina, Kseniya M., additional, Belova, Anastasiya A., additional, Kiseleva, Marina V., additional, Kaprin, Andrey D., additional, Alekseev, Boris Y., additional, Krasnov, George S., additional, and Kudryavtseva, Anna V., additional

Published
2019
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14. Epigenetic Changes in the Pathogenesis of Rheumatoid Arthritis

Author

Nemtsova, Marina V., primary, Zaletaev, Dmitry V., additional, Bure, Irina V., additional, Mikhaylenko, Dmitry S., additional, Kuznetsova, Ekaterina B., additional, Alekseeva, Ekaterina A., additional, Beloukhova, Marina I., additional, Deviatkin, Andrei A., additional, Lukashev, Alexander N., additional, and Zamyatnin, Andrey A., additional

Published
2019
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16. Genes associated with testicular germ cell tumors and testicular dysgenesis in patients with testicular microlithiasis.

Author

Dantsev IS, Ivkin EV, Tryakin AA, Godlevski DN, Latyshev OY, Rudenko VV, Mikhaylenko DS, Chernykh VB, Volodko EA, Okulov AB, Loran OB, and Nemtsova MV

Subjects
Adolescent, Adult, Calculi complications, Calculi diagnostic imaging, Case-Control Studies, Cohort Studies, DNA genetics, Gene Frequency, Genetic Predisposition to Disease, Gonadal Dysgenesis complications, Humans, Male, Neoplasms, Germ Cell and Embryonal complications, Polymerase Chain Reaction, Testicular Diseases complications, Testicular Diseases diagnostic imaging, Testicular Neoplasms complications, Ultrasonography, Young Adult, Calculi genetics, Gonadal Dysgenesis genetics, Neoplasms, Germ Cell and Embryonal genetics, Testicular Diseases genetics, Testicular Neoplasms genetics
Abstract

Testicular microlithiasis (TM) is one of the symptoms of testicular dysgenesis syndrome (TDS). TM is particularly interesting as an informative marker of testicular germ cell tumors (TGCTs). KIT ligand gene (KITLG), BCL2 antagonist/killer 1 (BAK1), and sprouty RTK signaling antagonist 4 (SPRY4) genes are associated with a high risk of TGCTs, whereas bone morphogenetic protein 7 gene (BMP7), transforming growth factor beta receptor 3 gene (TGFBR3), and homeobox D cluster genes (HOXD) are related to TDS. Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis, we investigated allele and genotype frequencies for KITLG (rs995030, rs1508595), SPRY4 (rs4624820, rs6897876), BAK1 (rs210138), BMP7 (rs388286), TGFBR3 (rs12082710), and HOXD (rs17198432) in 142 TGCT patients, 137 TM patients, and 153 fertile men (control group). We found significant differences in the KITLG GG_rs995030 genotype in TM (P = 0.01) and TGCT patients (P = 0.0005) compared with the control. We also revealed strong associations between KITLG_rs1508595 and TM (G allele, P = 0.003; GG genotype, P = 0.01) and between KITLG_rs1508595 and TGCTs (G allele, P = 0.0001; GG genotype, P = 0.0007). Moreover, there was a significant difference in BMP7_rs388286 between the TGCT group and the control (T allele, P = 0.00004; TT genotype, P = 0.00006) and between the TM group and the control (T allele, P = 0.04). HOXD also demonstrated a strong association with TGCTs (rs17198432 A allele, P = 0.0001; AA genotype, P = 0.001). Furthermore, significant differences were found between the TGCT group and the control in the BAK1_rs210138 G allele (P = 0.03) and the GG genotype (P = 0.01). KITLG and BMP7 genes, associated with the development of TGCTs, may also be related to TM. In summary, the KITLG GG_rs995030, GG_rs1508595, BMP7 TT_rs388286, HOXD AA_rs17198432, and BAK1 GG_rs210138 genotypes were associated with a high risk of TGCT development., Competing Interests: None

Published
2018
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