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1. Identification of Senescent Cells in the Bone Microenvironment

Author

Joshua N, Farr, Daniel G, Fraser, Haitao, Wang, Katharina, Jaehn, Mikolaj B, Ogrodnik, Megan M, Weivoda, Matthew T, Drake, Tamara, Tchkonia, Nathan K, LeBrasseur, James L, Kirkland, Lynda F, Bonewald, Robert J, Pignolo, David G, Monroe, and Sundeep, Khosla

Subjects
Male, Osteoblasts, DNA, Satellite, Osteocytes, Bone and Bones, Mice, Inbred C57BL, Phenotype, Cellular Microenvironment, Animals, Cell Lineage, Female, Myeloid Cells, Biomarkers, Cells, Cultured, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16
Abstract

Cellular senescence is a fundamental mechanism by which cells remain metabolically active yet cease dividing and undergo distinct phenotypic alterations, including upregulation of p16

Published
2016

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