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Developing binder-free Cu3N electrode materials by magnetron sputtering for high performance quasi-solid-state asymmetric supercapacitor.

This work aimed to analyze expression mechanism of micro ribonucleic acid (RNA)-10b (miR-10b) in cervical cancer (CC) based on Curcumin-monomethoxy polyethylene glycol-polylactic acid-drug-loaded nanoparticles (CUR-MPEG-PLA DLNPs). 36 Kunming mice were selected and randomly rolled into group A and group B, and 18 nude mice were deemed as controls. CUR-MPEG-PLA DLNPs were prepared for the treatment of 18 Kunming mice in group A. The CC tumor tissues of 36 Kunming mice were harvested, the miR-10b of CC cells was extracted, and the expression level of CC cells was detected by fluorescence quantitative polymerase chain reaction (qPCR). The results showed that the average particle size of CUR-MPEG-PLA DLNPs was 362.52±6.34 nm. The tumor inhibition rate of Kunming mice in group A against CC tumor strains 63.35±3.62% was considerably superior to those in group B (26.31 ±2.54%) (P < 0.05). In group A, expression rate of miR-10b (77.78%) was remarkably superior to controls (55.55%) (x2 = 2.364, P < 0.05). In 20 cases of CC tissues with positive expression of latent membrane protein 1 (LMP-1), expression of miR-10b in metastasis group was obviously higher relative to non-metastasis group (Z = −3.214, P < 0.05). In 16 cases of CC tissues with negative expression of LMP-1, expression of miR-10b in metastasis group was also considerably higher versus non-metastasis group (Z = −2.245, P < 0.05). In conclusion, the average particle size of CUR-MPEG-PLA DLNPs was 362.52 ±6.34 nm, the electromotive force was −9.23 mV, the dispersion coefficient was 0.064, the drug loading rate of nanoparticles was 8.54%, and the encapsulation rate was 72.36%. miR-10b has certain correlation with the metastasis of cervical cancer. LMP-1 gene has the function of promoting the metastasis of cervical cancer tumor cells, which may be dependent on miR-10b. CUR-MPEG-PLA DLNPs loading system can inhibit tumor growth obviously, and has excellent therapeutic effect in CC disease.

Long non-coding RNAs (lncRNAs) are involved in development of non-small cell lung cancer (NSCLC) by interacting with microRNAs (miRNAs) and/or mRNAs. However, the function of most lncRNAs in NSCLC ...

Stretchable and self-healing polymer gels with luminescent property are very promising materials for next generation soft optical devices. This work presents the preparation of self-healing and luminescent polymer gels by simply blending organometal halide perovskite nanocrystals (OHP NCs) with poly(dimethylsiloxane)-urea copolymer (PDMS-urea). On the one hand, the obtained luminescent gels are not only flexible, stretchable and relatively transparent, they also exhibit excellent self-healing capability due to the reversible hydrogen bonding network in the PDMS-urea copolymer. On the other hand, the embedding of OHP NCs (MAPbBr3 and MAPbI3 NCs) inside the hydrophobic PDMS-urea gel greatly improved the photoluminescence stability of OHP NCs against water. Their applications as phosphors for LEDs have been demonstrated. Both the MAPbBr3/PDMS-urea gel and MAPbI3/PDMS-urea gel can fully convert the blue emission of GaN chip to green and red emissions, respectively. These gels can be used as photoluminescent materials in flexible optical devices with good self-healing capability.

Poly(vinylidene fluoride/trifluoroethylene) (PVDF-TrFE) as a representative organic piezoelectric material have recently attracted wide attention. However, low dielectric permittivity limits its applications. We successfully prepared transparent PVDF-TrFE/graphene oxide (GO) ultrathin films. The addition of GO greatly improved the dielectric properties of PVDF-TrFE. The dielectric constant of the composite film is almost three times of that of the PVDF-TrFE film with the addition of 0.1 wt. % of GO nanosheets. Furthermore, the composite film also exhibits enhanced energy harvesting performance. The electric generator based on the PVDF-TrFE/ GO ultrathin film shows an output voltages of 49 mV under a pressure of 3.06 KPa. The advantages of transparence, flexibility and better energy harvesting performance make PVDF-TrFE/GO composite films much more attractive in promising applications of nano/micro electronic devices.

Organometal halide perovskites, as promising semiconductor materials for achieving future low-cost optoelectronic devices, suffer from inherent instability and undergo extremely fast degradation under exposure to moisture, UV light, or high temperature. Herein, we present a facile and low cost approach for the preparation of perovskite-based composite films via blending CH3NH3PbBr3 nanocrystals (MAPbBr3 NCs) with two kinds of commercially available silicone resins. The highest photoluminescence quantum yield of the prepared composite films is up to 62%. The composite films of MAPbBr3 NCs with phenyl methyl silicon resin (PMSR) show unprecedented stability against water, heat and UV exposure. Their applications as paints or as phosphors for the fabrication of green and white light LEDs are demonstrated.

Bismuth selenide (Bi2Se3) has attracted great attention as one of typical topological insulator materials. In this work, size-controllable Bi2Se3 nanoflowers (NFs) composed of numerous thin nanosheets are successfully synthesized by a hot-solution injection method under mild conditions. The structure and morphology of the obtained Bi2Se3 NFs are characterized by powder X-ray diffraction (XRD), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopic (EDS), and selected area electron diffraction (SAED) techniques. The reaction temperature, time, and surfactant ratio (oleylamine/oleic acid) affect the phase purity and morphology of Bi2Se3 samples. Based on the experimental results, the formation mechanism of Bi2Se3 nanoflowers is proposed. Meanwhile, the photocatalytic behavior of the as-prepared Bi2Se3 nanoflowers in the presence of H2O2 is explored and it is found that the degrading rate of RhB can reach 93% after 2 h visible light irradiation.

Glycyrrhiza Uralensis Polysaccharide (GCP), as a macromolecular polysaccharide extracted from the Traditional Chinese Medicine (TCM) - Licorice has been proved to inhibit tumor growth in vitro and in vivo; however, the specific anti-tumor mechanism of GCP needs to be further investigated. In this study, we explore the anti-tumor mechanism of GCP from the angle of gut microbiota. Colon carcinoma cells (CT-26) were used to set up a tumor-bearing mouse model. After 14 days of GCP treatment, the weights of tumors were significantly reduced. In addition, HE staining of tissue sections reflected that GCP could effectively inhibit tumor metastasis. 16SrRNA high-throughput sequencing of fecal samples showed a significant change between the model group and GCP group in the composition of gut microbiota. Subsequently, gut microbiota depletion and fecal transplantation experiments further confirmed the relationship between the anti-tumor effects of GCP and gut microbiota. Following depletion of gut microbiota, GCP cannot inhibit tumor growth. Fecal transplantation experiments found that transplanting the feces of GCP-treated mice, to a certain extent, could inhibit tumor growth and metastasis. These results indicate that Glycyrrhiza Polysaccharides exert anti-tumor effects by affecting gut microbiota composition. Keywords: Glycyrrhiza Uralensis Polysaccharides, Gut microbiota, Cancer, TCM, Anti-tumor

This work reports the preparation of crystals of two metal organic frameworks [(NH2CHNH2)][Zn(HCOO)3] (1) and [(NH2CHNH2)2][Cu2(HCOO)6] (2) by using the solvent evaporation method. Under the same experimental conditions, the obtained crystals show different crystal structures. The complex 1 forms 3D structure geometry with one Zn(Ⅱ) ion in the center of an octahedral coordination environment, which is bridged with six nearest Zn(Ⅱ) ions by the formate ligands. The 3D scaffold of the complex 2 consists of two copper ions (Cu1 and Cu2) in the center of an octahedral coordination environment bridged by formate ligands. Magnetic study shows diamagnetic susceptibility for [NH2CHNH2][Zn(HCOO)3] and antiferromagnetic coupling between the Cu(Ⅱ) ions for [(NH2CHNH2)2][Cu2(HCOO)6].

Summary Objective This study was designed to investigate the potentially prognostic indicators of early laryngeal squamous cell carcinomas (LSCCs), including human papillomavirus (HPV) status. Methods A total of 336 patients with T2N0–1M0 LSCC were included in this study. Clinical data were collected from archival documents, and HPV infection and p16 INK4A expression were detected. Results A total of 32/318 cases of high-risk HPV infection and 10/336 cases of p16 INK4A overexpression were found. Three hundred eighteen tumors were classified into a three-class model according to HPV infection and p16 INK4A expression: class I, HPV+/p16+; class II, HPV+/p16−; and class III, HPV−/p16−. Class III had a trend of decreased overall survival (OS) ( P = 0.076) and a markedly low relapse-free survival (RFS) ( P = 0.022) compared with class I and class II. HPV-positive cases (class I plus class II) had a significantly longer OS ( P = 0.038) and RFS ( P = 0.006). In multivariate analysis, HPV-positive ( P = 0.020), nonanemia ( P = 0.011), and N0 stage ( P = 0.005) were significant predictors for high RFS. But only HPV-positive ( P = 0.047) and nonanemia ( P Conclusion A trend of discrete survival among HPV+/p16+, HPV+/p16−, and HPV−/p16 classes was found in early LSCCs. We suggest that HPV infection and hemoglobin level are the potential factors that can stratify outcome of early LSCCs.

To fully and rationally exploit local living marine resources while have a sustainable, efficient and healthy development of shellfish culture in the Dadeng Island sea area of Xiamen, this paper determined and analyzed the related model parameters of this area, including chlorophyll a, primary productivity, phytoplankton organic carbon tent, wild filter feeder yields in subtidal and intertidal zones and suspension culture area, cultured shellfish filtration rate and organic carbon content, shellfish's total weight to fresh meat ratio, and adopted the Nutrient namic Model and Coastal Waters' Energy Flow Analysis Model to estimate the ecological capacity of shellfish this area, from which, the wild filter feeder yields were deducted for estimating shellfish carrying capacity. model established by Fang Jianguang was also used to estimate the shellfish carrying capacity. Statistics analysis was used to estimate the suitable culture area of shellfish and other species, aiming at limiting local shellfish ture and optimizing the culture of various species mollusks. According to the estimation of the three models, shellfish carrying capacity in this area should be 35,248-39,990 tons, with an average of 37,488 tons, 140,008 x 10(4) - 158,850 x 10(4) individuals, averaging 148,903 x 10(4). The theoretically suitable culture area 2 145 hm2, 1,900 hm2 for Ostreidae, 81 hm2 for razor clam (Sinonovacula constricta), 20 hm2 for blood (Tegillarca granosa), and 144 hm2 for musculus (Musculus senhousei). In 2000, the actual culture area of shellfish and other species in the waters around Dadeng surpassed the estimated suitable culture area. It is proposed that some measures should be taken to reduce the overexploited area.