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4. A Clinical Journey Mobile Health App for Perioperative Patients: Cross-sectional Study

Author

Willems, Stijn J, Coppieters, Michel W, Pronk, Yvette, Diks, Miranda J F, van der Heijden, Klaas W A P, Rooker, Servan, and Scholten-Peeters, Gwendolyne G M

Subjects
Medical technology, R855-855.5
Abstract

BackgroundMobile eHealth apps are important tools in personal health care management. The Patient Journey app was developed to inform patients with musculoskeletal disorders during their perioperative period. The app contains timely information, video exercises, and functional tasks. Although the Patient Journey app and other health apps are widely used, little research is available on how patients appreciate these apps. ObjectiveThe primary aim of this study was to evaluate the user-friendliness of the Patient Journey app in terms of its usability and the attitudes of users toward the app. The secondary aim was to evaluate positive and negative user experiences. MethodsA web-based questionnaire was sent to 2114 patients scheduled for surgery for a musculoskeletal disorder. Primary outcomes were usability (measured with the System Usability Scale) and user attitudes regarding the Patient Journey app (assessed with the second part of the eHealth Impact Questionnaire). The secondary outcomes were evaluated with multiple choice questions and open-ended questions, which were analyzed via inductive thematic content analyses. ResultsOf the 940 patients who responded, 526 used the Patient Journey app. The usability of the app was high (System Usability Scale: median 85.0, IQR 72.5-92.5), and users had a positive attitude toward the Information and Presentation provided via the app (eHealth Impact Questionnaire: median 78.0, IQR 68.8-84.4). The app did not adequately improve the users’ confidence in discussing health with others (eHealth Impact Questionnaire: median 63.9, IQR 50.0-75.0) or motivation to manage health (eHealth Impact Questionnaire: median 61.1, IQR 55.6-72.2). Three core themes emerged regarding positive and negative user experiences: (1) content and information, (2) expectations and experiences, and (3) technical performance. Users experienced timely information and instructions positively and found that the app prepared and guided them optimally through the perioperative period. Negative user experiences were overly optimistic information, scarcely presented information about pain (medication), lack of reference data, insufficient information regarding clinical course deviations and complications, and lack of interaction with clinicians. ConclusionsThe Patient Journey app is a usable, informative, and presentable tool to inform patients with musculoskeletal disorders during their perioperative period. The qualitative analyses identified aspects that can further improve the user experiences of the app.

Published
2021
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5. In COVID-19 Health Messaging, Loss Framing Increases Anxiety with Little-to-No Concomitant Benefits: Experimental Evidence from 84 Countries

Author

Dorison, C. A., Lerner, J. S., Heller, B. H., Rothman, A. J., Kawachi, I. I., Wang, K., Rees, V. W., Gill, B. P., Gibbs, N., Ebersole, C. R., Vally, Z., Tajchman, Z., Zsido, A. N., Zrimsek, M., Chen, Z., Ziano, I., Gialitaki, Z., Ceary, C. D., Jang, Y., Lin, Y., Kunisato, Y., Yamada, Y., Xiao, Q., Jiang, X., Du, X., Yao, E., Ryan, W., Wilson, J. P., Cyrus-Lai, W., Jimenez-Leal, W., Law, W., Unanue, W., Collins, W. M., Richard, K. L., Vranka, M., Ankushev, V., Schei, V., DePaola, C., Lerche, V., Kovic, V., Križanić, V., Kadreva, V. H., Adoric, V. C., Tran, U. S., Yeung, S. K., Hassan, W., Houston, R., Machin, M. A., Lima, T. J. S., Ostermann, T., Frizzo, T., Sverdrup, T. E., House, T., Gill, T., Fedotov, M., Paltrow, T., Jernsäther, T., Rahman, T., Machin, T., Koptjevskaja-Tamm, M., Hostler, T. J., Ishii, T., Szaszi, B., Adamus, S., Suter, L., von Bormann, S. M., Habib, S., Studzinska, A., Stojanovska, D., Janssen, S. M. J., Stieger, S., Schulenberg, S. E., Tatachari, S., Azouaghe, S., Sorokowski, P., Sorokowska, A., Song, X., Morbée, S., Lewis, S. C., Sinkolova, S., Grigoryev, D., Drexler, S. M., Daches, S., Levine, S. L., Geniole, S. N., Akter, S., Vračar, S., Massoni, S., Costa, S., Zorjan, S., Sarıoğuz, E., Morales Izquierdo, S., Tshonda, S. S., Alves, S. G., Pöntinen, S., Álvarez Solas, S., Ordoñez-Riaño, S., Batić Očovaj, S., Onie, S., Lins, S., Biberauer, T., Çoksan, S., Khumkom, S., Sacakli, A., Ruiz-Fernández, S., Geiger, S. J., FatahModares, S., Walczak, R. B., Betlehem, R., Vilar, R., Doekemeijer, R., Cárcamo, R., Ross, R. M., McCarthy, R., Ballantyne, T., Westgate, E. C., Gargurevich, R., Afhami, R., Ren, D., Monteiro, R. P., Reips, U-D., Reggev, N., Calin-Jageman, R. J., Pourafshari, R., London, R., Oliveira, R., Nedelcheva-Datsova, M., Rahal, R-M., Ribeiro, R. R., Radtke, T., Searston, R., Jai-ai, R., Habte, R., Zdybek, P., Chen, S-C., Wajanatinapart, P., Maturan, P. L. G., Perillo, J. T., Isager, P. M., Kačmár, P., Macapagal, P. M., Maniaci, M. R., Szwed, P., Hanel, P. H. P., Forbes, P. A. G., Arriaga, P., Paris, B., Parashar, N., Papachristopoulos, K., Sebastián-Correa, P., Kácha, O., Bernardo, M., Campos, O., Niño Bravo, O., Galindo-Caballero, O. J., Ogbonnaya, C. E., Bialobrzeska, O., Kiselnikova, N., Simonovic, N., Cohen, N., Nock, N. L., Hernandez, A., Thogersen-Ntoumani, C., Ntoumanis, N., Johannes, N., Albayrak-Aydemir, N., Say, N., Neubauer, A. B., Martin, N. I., Torunsky, N., van Antwerpen, N., Van Doren, N., Sunami, N., Rachev, N. R., Majeed, N. M., Schmidt, N-D., Nadif, K., Corral-Frías, N. S., Ouherrou, N., Abbas, N., Pantazi, M., Lucas, M. Y., Vasilev, Martin R., Ortiz, M. V., Butt, M. M., Kurfali, M., Kabir, M., Muda, R., Tejada Rivera, M. C., Sirota, M., Seehuus, M., Parzuchowski, M., Toro, M., Hricova, M., Alarcón Maldonado, M., Rentzelas, P., Vansteenkiste, M., Metz, M. A., Marszalek, M., Karekla, M., Mioni, G., Bosma, M. J., Westerlund, M., Vdovic, M., Bialek, M., Silan, M. A., Anne, M., Misiak, M., Gugliandolo, M. C., Grinberg, M., Capizzi, M., Espinoza Barría, M. F., Kurfali, M. A., Mensink, M. C., Harutyunyan, M., Khosla, M., Dunn, M. R., Korbmacher, M., Adamkovič, M., Ribeiro, M. F. F., Terskova, M., Hruška, M., Martončik, M., Jansen, M., Voracek, M., Čadek, M., Frias-Armenta, M., Kowal, M., Topor, M., Roczniewska, M., Oosterlinck, M., Braun Kohlová, M., Paruzel-Czachura, M., Sabristov, M., Romanova, M., Papadatou-Pastou, M., Lund, M. L., Antoniadi, M., Magrin, M. E., Jones, M. V., Ortiz, M. S., Manavalan, M., Muminov, A., Kossowska, M., Friedemann, M., Wielgus, M., van Hooff, M. L. M., Varella, M. A. C., Standage, M., Nicolotti, M., Colloff, M. F., Bradford, M., Vaughn, L. A., Eudave, L., Vieira, L., Sanabria Pineda, L. M., Matos, L., Calderón Pérez, L., Lazarevic, L. B., Jaremka, L. M., Smit, E. S., Kushnir, E., Ferguson, L. J., Anton-Boicuk, L., Lins de Holanda Coelho, G., Ahlgren, L., Liga, F., Levitan, C. A., Micheli, L., Gunton, L-A., Volz, L., Stojanovska, M., Boucher, L., Samojlenko, L., Javela Delgado, L. G., Kaliska, L., Labadi, B., Warmelink, L., Rojas-Berscia, L. M., Yu, K., Wylie, K., Wachowicz, J., Desai, K., Barzykowski, K., Kozma, L., Evans, K., Kirgizova, K., Agesin, B. E., Koehn, M. A., Wolfe, K., Korobova, T., Morris, K., Klevjer, K., van Schie, K., Vezirian, K., Damnjanović, K., Krabbe Thommesen, K., Schmidt, K., Filip, K., Staniaszek, K., Grzech, K., Hoyer, K., Moon, K., Khaobunmasiri, S., Rana, K., Janjić, K., Suchow, J. W., Kielińska, J., Cruz Vásquez, J. E., Chanal, J., Beitner, J., Vargas-Nieto, J. C., Roxas, J. C. T., Taber, J., Urriago-Rayo, J., Pavlacic, J. M., Benka, J., Bavolar, J., Soto, J. A., Olofsson, J. K., Vilsmeier, J. K., Messerschmidt, J., Czamanski-Cohen, J., Waterschoot, J., Moss, J. D., Boudesseul, J., Lee, J. M., Kamburidis, J., Joy-Gaba, J. A., Zickfeld, J., Miranda, J. F., Verharen, J. P. H., Hristova, E., Beshears, J. E., Đorđević, J. M., Bosch, J., Valentova, J. V., Antfolk, J., Berkessel, J. B., Schrötter, J., Urban, J., Röer, J. P., Norton, J. O., Silva, J. R., Pickering, J. S., Vintr, J., Uttley, J., Kunst, J. R., Ndukaihe, I. L. G., Iyer, A., Vilares, I., Ivanov, A., Ropovik, I., Sula, I., Sarieva, I., Metin-Orta, I., Prusova, I., Pinto, I., Bozdoc, A. I., Almeida, I. A. T., Pit, I. L., Dalgar, I., Zakharov, I., Arinze, A. I., Ihaya, K., Stephen, I. D., Gjoneska, B., Brohmer, H., Flowe, H., Godbersen, H., Kocalar, H. E., Hedgebeth, M. V., Chuan-Peng, H., Sharifian, M. H., Manley, H., Akkas, H., Hajdu, N., Azab, H., Kaminski, G., Nilsonne, G., Anjum, G., Travaglino, G. A., Feldman, G., Pfuhl, G., Czarnek, G., Marcu, G. M., Hofer, G., Banik, G., Adetula, G. A., Bijlstra, G., Verbruggen, F., Kung, F. Y. H., Martela, F., Foroni, F., Forest, J., Singer, G., Muchembled, F., Azevedo, F., Mosannenzadeh, F., Marinova, E., Štrukelj, E., Etebari, Z., Baskin, E., Garcia, E. O. L., Musser, E., van Steenkiste, I. M. M., Bradshaw, E. L., Ahn, E. R., Quested, E., Pronizius, E., Jackson, E. A., Manunta, E., Agadullina, E., Šakan, D., Dursun, P., Dujols, O., Dubrov, D., Willis, M., Tümer, M., Beaudry, J. L., Popović, D., Dunleavy, D., Djamai, I., Krupić, D., Herrera, D., Vega, D., Du, H., Mola, D., Chakarova, D., Davis, W. E., Holford, D. L., Lewis, D. M. G., Vaidis, D. C., Hausman Ozery, D., Zambrano Ricaurte, D., Storage, D., Sousa, D., Serrato Alvarez, D., Boller, D., Dalla Rosa, A., Dimova, D., Marko, D., Moreau, D., Reeck, C., Correia, R. C., Whitt, C. M., Lamm, C., Singh Solorzano, C., von Bastian, C.C., Sutherland, C. A. M., Overkott, C., Aberson, C. L., Wang, C., Niemiec, C. P., Reimer, C., Karashiali, C., Noone, C., Chiu, F., Picciocchi, C., Eben, C., Brownlow, C., Karaarslan, C., Cellini, N., Esteban-Serna, C., Reyna, C., Ferreyra, C., Batres, C., Li, R., Grano, C., Carpentier, J., Tamnes, C. K., Fu, C. H. Y., Ishkhanyan, B., Bylinina, L., Jaeger, B., Bundt, C., Bulut Allred, T., Vermote, B. J., Bokkour, A., Bogatyreva, N., Shi, J., Chopik, W. J., Antazo, B., Becker, M., Bayyat, M. M., Cocco, B., Chou, W-L., Barkoukis, V., Aczel, B., Baklanova, E., Bai, H., Balci, B. B., Babinčák, P., Soenens, B., Dixson, B. J. W., Mokady, A., Kappes, H. B., Atari, M., Szala, A., Szabelska, A., Aruta, J. J. B., Domurat, A., Arinze, N. C., Modena, A., Adiguzel, A., Monajem, A., El Arabi, K. A., Özdoğru, A. A., Rothbaum, A. O., Torres, A. J. O., Theodoropoulou, A., Skowronek, A., Jurković, A. P., Singh, A., Kassianos, A. P., Findor, A., Hartanto, A., Thibault Landry, A., Ferreira, A., Caetano Santos, A., De la Rosa-Gomez, A., Gourdon-Kanhukamwe, A., Luxon, A. M., Todsen, A. L., Karababa, A., Janak, A., Pilato, A., Bran, A., Tullett, A. M., Kuzminska, A. O., Krafnick, A. J., Urooj, A., Khaoudi, A., Ahmed, A., Groyecka-Bernard, A., Askelund, A. D., Adetula, A., Belaus, A., Charyate, A. C., Wichman, A. L., Stoyanova, A., Greenburgh, A., Thomas, A. G., Arvanitis, A., Forscher, P. S., Mallik, P. R., Primbs, M. A., Miller, J. K., Moshontz, H., Urry, H. L., IJzerman, H., Basnight-Brown, D. M., Chartier, C. R., Buchanan, E. M., Coles, N. A., MÜ, Eğitim Fakültesi, Eğitim Bilimleri Bölümü, Kocalar, Halil Emre, Faculdade de Psicologia e de Ciências da Educação, Organizational Psychology, Jernsäther, Teodor [0000-0002-7030-3299], Tatachari, Srinivasan [0000-0003-1838-2361], Geiger, Sandra J [0000-0002-3262-5609], Butt, Muhammad Mussaffa [0000-0001-5271-111X], Varella, Marco A C [0000-0002-7274-7360], Stephen, Ian D [0000-0001-9714-8295], Kaminski, Gwenael [0000-0001-5300-5655], Bai, Hui [0000-0003-2671-5955], Coles, Nicholas A [0000-0001-8583-5610], Apollo - University of Cambridge Repository, Center Ph. D. Students, Department of Social Psychology, Tilburg University, and Medical and Clinical Psychology

Subjects
Nudges, Behaviour Change and Well-being, ddc:150, 230 Affective Neuroscience, SDG 3 - Good Health and Well-being, message framing, anxiety, nudges, COVID-19, Message framing, General Medicine, Anxiety
Abstract

Contains fulltext : 284232.pdf (Publisher’s version ) (Closed access) The COVID-19 pandemic (and its aftermath) highlights a critical need to communicate health information effectively to the global public. Given that subtle differences in information framing can have meaningful effects on behavior, behavioral science research highlights a pressing question: Is it more effective to frame COVID-19 health messages in terms of potential losses (e.g., "If you do not practice these steps, you can endanger yourself and others") or potential gains (e.g., "If you practice these steps, you can protect yourself and others")? Collecting data in 48 languages from 15,929 participants in 84 countries, we experimentally tested the effects of message framing on COVID-19-related judgments, intentions, and feelings. Loss- (vs. gain-) framed messages increased self-reported anxiety among participants cross-nationally with little-to-no impact on policy attitudes, behavioral intentions, or information seeking relevant to pandemic risks. These results were consistent across 84 countries, three variations of the message framing wording, and 560 data processing and analytic choices. Thus, results provide an empirical answer to a global communication question and highlight the emotional toll of loss-framed messages. Critically, this work demonstrates the importance of considering unintended affective consequences when evaluating nudge-style interventions. 26 p.

Published
2022
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6. Moral Status for Malware! The Difficulty of Defining Advanced Artificial Intelligence

Author

Miranda J F Mowbray

Subjects
Moral Obligations, criteria for consciousness, Health (social science), Computer science, media_common.quotation_subject, Moral Status, 0603 philosophy, ethics and religion, computer.software_genre, artificial intelligence (AI), Code (semiotics), Software, Artificial Intelligence, Humans, media_common, business.industry, malware, Health Policy, 06 humanities and the arts, Issues, ethics and legal aspects, Incentive, Ethical obligation, 060302 philosophy, code, Malware, Robot, robots, 060301 applied ethics, Artificial intelligence, Consciousness, business, computer
Abstract

The suggestion has been made that future advanced artificial intelligence (AI) that passes some consciousness-related criteria should be treated as having moral status, and therefore, humans would have an ethical obligation to consider its well-being. In this paper, the author discusses the extent to which software and robots already pass proposed criteria for consciousness; and argues against the moral status for AI on the grounds that human malware authors may design malware to fake consciousness. In fact, the article warns that malware authors have stronger incentives than do authors of legitimate software to create code that passes some of the criteria. Thus, code that appears to be benign, but is in fact malware, might become the most common form of software to be treated as having moral status.

Published
2021
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7. A Clinical Journey Mobile Health App for Perioperative Patients: Cross-sectional Study (Preprint)

Author

Stijn J Willems, Michel W Coppieters, Yvette Pronk, Miranda J F Diks, Klaas W A P van der Heijden, Servan Rooker, and Gwendolyne G M Scholten-Peeters

Subjects
mental disorders
Abstract

BACKGROUND Mobile eHealth apps are important tools in personal health care management. The Patient Journey app was developed to inform patients with musculoskeletal disorders during their perioperative period. The app contains timely information, video exercises, and functional tasks. Although the Patient Journey app and other health apps are widely used, little research is available on how patients appreciate these apps. OBJECTIVE The primary aim of this study was to evaluate the user-friendliness of the Patient Journey app in terms of its usability and the attitudes of users toward the app. The secondary aim was to evaluate positive and negative user experiences. METHODS A web-based questionnaire was sent to 2114 patients scheduled for surgery for a musculoskeletal disorder. Primary outcomes were usability (measured with the System Usability Scale) and user attitudes regarding the Patient Journey app (assessed with the second part of the eHealth Impact Questionnaire). The secondary outcomes were evaluated with multiple choice questions and open-ended questions, which were analyzed via inductive thematic content analyses. RESULTS Of the 940 patients who responded, 526 used the Patient Journey app. The usability of the app was high (System Usability Scale: median 85.0, IQR 72.5-92.5), and users had a positive attitude toward the Information and Presentation provided via the app (eHealth Impact Questionnaire: median 78.0, IQR 68.8-84.4). The app did not adequately improve the users’ confidence in discussing health with others (eHealth Impact Questionnaire: median 63.9, IQR 50.0-75.0) or motivation to manage health (eHealth Impact Questionnaire: median 61.1, IQR 55.6-72.2). Three core themes emerged regarding positive and negative user experiences: (1) content and information, (2) expectations and experiences, and (3) technical performance. Users experienced timely information and instructions positively and found that the app prepared and guided them optimally through the perioperative period. Negative user experiences were overly optimistic information, scarcely presented information about pain (medication), lack of reference data, insufficient information regarding clinical course deviations and complications, and lack of interaction with clinicians. CONCLUSIONS The Patient Journey app is a usable, informative, and presentable tool to inform patients with musculoskeletal disorders during their perioperative period. The qualitative analyses identified aspects that can further improve the user experiences of the app.

Published
2020
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8. A Clinical Journey Mobile Health App for Perioperative Patients: Cross-sectional Study

Author

S. Rooker, Yvette Pronk, Miranda J F Diks, Gwendolyne G M Scholten-Peeters, Michel W. Coppieters, Klaas W A P van der Heijden, Stijn J. Willems, Neuromechanics, AMS - Musculoskeletal Health, and AMS - Rehabilitation & Development

Subjects
020205 medical informatics, applications, Health Informatics, Human Factors and Ergonomics, 02 engineering and technology, patient education, rehabilitation, 03 medical and health sciences, 0302 clinical medicine, Musculoskeletal disorder, Nursing, mental disorders, 0202 electrical engineering, electronic engineering, information engineering, eHealth, medicine, Medical technology, 030212 general & internal medicine, adherence, R855-855.5, mHealth, Multiple choice, Original Paper, user-friendliness, musculoskeletal, business.industry, System usability scale, Usability, Perioperative, medicine.disease, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], usability, disability, technology, Human medicine, Psychology, business, Patient education, feasibility
Abstract

Background Mobile eHealth apps are important tools in personal health care management. The Patient Journey app was developed to inform patients with musculoskeletal disorders during their perioperative period. The app contains timely information, video exercises, and functional tasks. Although the Patient Journey app and other health apps are widely used, little research is available on how patients appreciate these apps. Objective The primary aim of this study was to evaluate the user-friendliness of the Patient Journey app in terms of its usability and the attitudes of users toward the app. The secondary aim was to evaluate positive and negative user experiences. Methods A web-based questionnaire was sent to 2114 patients scheduled for surgery for a musculoskeletal disorder. Primary outcomes were usability (measured with the System Usability Scale) and user attitudes regarding the Patient Journey app (assessed with the second part of the eHealth Impact Questionnaire). The secondary outcomes were evaluated with multiple choice questions and open-ended questions, which were analyzed via inductive thematic content analyses. Results Of the 940 patients who responded, 526 used the Patient Journey app. The usability of the app was high (System Usability Scale: median 85.0, IQR 72.5-92.5), and users had a positive attitude toward the Information and Presentation provided via the app (eHealth Impact Questionnaire: median 78.0, IQR 68.8-84.4). The app did not adequately improve the users’ confidence in discussing health with others (eHealth Impact Questionnaire: median 63.9, IQR 50.0-75.0) or motivation to manage health (eHealth Impact Questionnaire: median 61.1, IQR 55.6-72.2). Three core themes emerged regarding positive and negative user experiences: (1) content and information, (2) expectations and experiences, and (3) technical performance. Users experienced timely information and instructions positively and found that the app prepared and guided them optimally through the perioperative period. Negative user experiences were overly optimistic information, scarcely presented information about pain (medication), lack of reference data, insufficient information regarding clinical course deviations and complications, and lack of interaction with clinicians. Conclusions The Patient Journey app is a usable, informative, and presentable tool to inform patients with musculoskeletal disorders during their perioperative period. The qualitative analyses identified aspects that can further improve the user experiences of the app.

Published
2020
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14. Abstracts of papers medicinal chemical meeting

Author

Damsma, G., Westerink, B. H. C., de Vries, J. B., Horn, A. S., Rettenmayr, N., de Miranda, J. F. Rodrigues, Lambrecht, G., Mutschler, E., Russel, F. G. M., van Galen, P. J. M., van Viijmen, H. W. Th., Ijzerman, A. P., Soudijn, W., Vromans, R. M., van de Straat, R., Groeneveld, M., Vermeiden, N. P. E., Siero, H. L. M., van Zwam, A. J. G., de Miranda, J. F. Rodriques, van Ginneken, C. A. M., Willems, P. H. G. M., de Pont, J. J. H. H. M., van Gelderen, J. G., Pruijn, F. B., Bast, A., de Zwart, M. A. H., van der Goot, H., Timmerman, H., Kramer, K., Voss, H. P., Grimbergen, J. A., Goeptar, A. R., Haenen, G. R. M. M., Veerman, M., Vermeulen, N. P. E., Boom, S. P. A., Koper, J. G., Leurs, J. N. L. Go. R., Rekka, E., Sterk, G. J., van der Weide, Jan, Tendijck, H., Tepper, P. G., Horn, A. B., Bosker, F. J., van Bussel, F. J., Plug, M. J., Dijk, J., Tepper, P., Möller, W., Leusen, F. J. J., van Vlijmen, H. W. Th., de Kaste, D., van Amsterdam, J. G. C., Llorens-Cortes, C., Vleeming, W., v. d. Wouw, P. A., v. Rooij, H. H., Wemer, J., Porsius, A. J., Lusthof, K. J., de Mol, N. J., Janssen, L. H. M., Bakri, Aziz, Janssen, Lambert H. M., Wilting, Jaap, Kelder, P. P., Kuit, M. C. A. W., van Sterkenburg, E. L. M., Wilting, J., Bos, O. J. M., and Fischer, M. J. E.

Published
1987
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15. Occurrence of mastitis before and after homeopathic treatment in dairy cattle, in the state of Rio de Janeiro, Brazil.

Author

SOUZA, R. M., MIRANDA, J. F., SILVA, G. C. L., MEDEIROS, T. P. X., and BARBOSA, G. M.

Subjects
*CATTLE, *HOMEOPATHIC agents, *DAIRY cattle, *MASTITIS, *ANIMAL herds, *CATTLE breeds
Abstract

Bovine mastitis is an infectious disease that impacts milk production and leads to economic losses and public health problems. It can present in subclinical and clinical forms. The treatment generally used is antibiotic therapy, but the resistance to bovine's Staphylococcus aureus has increased in Brazil (Rabello et.al., 2020), which makes homeopathy an important therapy option. In our study, two dairy herds in Rio de Janeiro state were evaluated, regarding the presence of mastitis, in two subsequent periods: (1) Control Stage (CS): antibiotic therapy, chosen after isolation, identification and antimicrobial susceptibility testing of mastitis bacteria, and (2) Experimental Stage (ES): nosode (Staphylococcus aureus 30 cH + Staphylococcus spp. 30 cH + Enterobacteriaceae 30 cH, in equal parts), whose microorganisms were isolated from mastitis in the dairy herds studied. The CS took place from February to April 2022 and the ES from May to July 2022. To analyze the treatment, the animals were evaluated with the California Mastitis Test (CMT), and the milk from mammary quarters, that presented mastitis, was collected and analyzed for bacterial isolation and identification in MALDITOF. During the CS and ES, 7 CMTs were performed. The occurrence of subclinical mastitis in the CS in 1681 analyzed quarters was 36.4% (n= 608), while in the ES, in 1290 analyzed quarters, mastitis was 26.5% (n= 335). The number of samples in the CS was slightly higher because some animals were removed from production (milk drying) during the ES. There was a reduction (p<0.0001) in the occurrence of subclinical mastitis after homeopathic treatment. In both stages, Staphylococcus spp. was the most prevalent microorganism. Considering that the two dairy herds were analyzed during CS and ES, some external factors such as environmental, origin, and breed of cattle and level of exposure to bacteria remained the same in both periods, it is inferred that there was an insignificant influence on the results. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Muscle forces of the shoulder complex with different external loads and movements: a biomechanical simulation analysis.

Author

Dhein, William, Brodt, Guilherme A., de Toledo, Joelly M., Miranda J. F. Loss, Iã F. Miranda, and Loss, Jefferson F.

Subjects
MUSCLES, SHOULDER, SHOULDER injuries, SHOULDER joint range of motion, KINEMATICS, BIOMECHANICS
Abstract

Copyright of Revista Brasileira de Ciência e Movimento: RBCM is the property of Revista Brasileira de Ciencia e Movimento and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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17. Abstracts of papers

Author

Rodrigues de Miranda, J. F., van der Weide, J., Tepper, P. C., de Vries, J. B., Horn, A. S., Ijzerman, A. P., Bultsma, T., Timmerman, H., Tulp, M. Th. M., Janssen, L. H. M., de Kaste, D., van Buuren, K. J. H., Soudijn, W., Kloosterboer, H. J., Bergink, E. W., van Oene, Joop C., Kebabian, John W., Rademnker, B., Bast, A., Kramer, K., Rademaker, B., Bakri, A., BeijersberRen van Henegouwen, G. M. J., de Vries, H., Wilting, J., Underberg, W. J. M., Busker, R. W., Beijersbergen van Henesouwen, G. M. J., Beijersbergen van Henegouwen, G. M. J., de Zwart, M., van der Goot, H., Donne-Op den Kelder, G. M., Bijloo, G. J., Haaksma, E. E. J., Eriks, J. Ch., Severne, Y., Nerme, V., Vauquelin, G., Leurs, R., Mennen, M. M., Plantjé, J. F., Stoof, J. C., 't Hart, B. J., de Gier, J. J., Straat, R. v. d., Kulkons, T., Debets, A. J. J., de Vries, J., Verneulen, H. P. E., van der Werf, J. F., van der Kuyl, A. C., van Maanen, J. M. S., de Ruiter, C., Kootstra, P. R., Broersen, J., Lafleur, M. V. M., Retèl, J., Pinedo, H. M., Wezel, K., Bakker, E. I., Wolf, M., Beld, A. J., and Mutschler, E.

Published
1985
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18. Abstracts of papers

Author

Slangen, J. L., Ciurgea, C. E., Jolles, J., van Amsterdam, J. G. C., van Buuren, K. J. H., Soudijn, W., van Oene, J. C., de Vries, J. B., Dijkstra, D., Renkema, R. J. W., Tepper, P. G., Horn, A. S., Bast, A., Savenije-Chapel, E. M., Kroes, B. H., Nugteren, H. A., de Haan, F. H. N., Joosten, J. G. H., Jansen, A. C. A., Koopmans, R. E., Rekker, R. F., Ijzerman, A. P., Aué, G., Bultsma, T., Timmerman, H., Krielaart, M. J., von der Schaar, M. W. G., Rademaker, B., Zaagsma, J., van Koppen, C. J., Siero, H. L. M., Rodrigues de Miranda, J. F., Beld, A. J., Ariëns, E. J., Scheres, H. M. E., Klaassen, A. B. M., Kuypers, W., van Amsterdam, F. T. M., Sterk, G. J., van der Goot, H., van Maanen, J. M. S., Cobas, F., de Ruiter, C., de Vries, J., Pinedo, H. M., Linschoten, M. R., Gaisser, H. -D., Dröge, J. H. M., Janssen, L. H. M., Wilting, J., Voorbrood, E. L. M., Kremer, J. M. H., Bakri, A., Beijersbergen van Henegouwen, G. M. J., de Vries, H., Huf, F. A., Sedee, A. G. J., Lusthof, K. J., Lodder, G., de Mol, N. J., Busker, R. W., Drexler, T. B., Weeda, L., Maanders, J. P. A. C. M., Posthuma, R. M., Mohn, G. R., Plantlé, J. F., Daus, F. J., Hansen, H. A., Stoof, J. C., Hazelhoff, B., Dijkstra, P., Mulder, T., Elferink, F., van der Vijgh, W. J. F., Brussee, J., te Koppele, J. M., and Groenendijk, J. L. G.

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1984
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19. Abstracts of papers medicinal chemistry meeting

Author

Timmerman, H., Wilting, J., Tulp, M. Th. M., Kelder, J., Saxena, Pramod R., van Nueten, J. M., Janssens, W. J., Bast, A., Freyne, E. J., Raeymaekers, A. H. M., van Gelder, J., Venet, M. G., Sipido, V. K., de Clerck, F., van Lommen, Guy, de Bruvn, Marcel, Schroven, Marc, Wouters, W., Rademaker, B., Rollema, Hans, Booth, Ray, Castagnoli, Jr., Neal, Timmerman, W., Westerink, B. H. C., de Vries, J. B., Tepper, P. G., Horn, A. S., Pirovano, I. M., van Galen, P. J. M., Ijzerman, A. P., Soudijn, W., Voorschuur, A. H., Garritsen, Anja, Ijzerman, Adriaan f., Bijloo, G. J., van der Goot, H., Timmerman, H., van der Vlies, A. J., Haaksma, E. E. J., Kelder, G. M. Donné-Op den, Voss, H. -P., Ravenek, W., Vernooijs, P., Ciere, S., Klaver, C. J., Koymans, Luc, van Lenthe, Joop H., van de Straat, Ronald, Vermeulen, Nico P. E., Bastiaans, H. M. M., Kramer, K., Dijkstra, H., Smink, C. G. W. C., Haenen, G. R. M. M., de Rooij, B. M., Convents, A., Vauquelin, G., de Miranda, J. F. Rodrigues, Feifel, R., Aasen, A., Strohmann, C., Tacke, R., Waelbroeck, M., Christophe, J., Lambrecht, G., Mutschler, E., van Rijn, C. M., Velden, T. vd, Feenstra, M. G. P., Hommes, O. R., Vleeming, W., Pijnenburg, R., van Rooij, H. H., Wemer, J., Porsius, A. J., van Helden, S. P., Claessens, A. J., van Drooge, M. J., Jansen, A. C. A., Janssen, L. H. M., Kelder, P. P., de Mol, N. J., Lusthot, K. J., Richter, W., de Kaste, D., Wynne, H. J. A., Blankesteijn, W. M., Grasveld, P., de Vos, C. J., de Graaf, J. S., Witmans, C. J., Grol, C. J., Wierenga, R. K., Hol, W. G. J., Opperdoes, F. R., van der Vliet, A., and Tuinstra, T. J. R.

Published
1988
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20. Abstracts of papers pharmacological meeting

Author

Beckorinqh, J. J., Korstanje, C., van Zwieten, P. A., Boddeke, H. W. G. M., Jonkman, F. A. M., Daemen, M., van Essen, H., Smits, J., Thljssen, H., de Bruijn, E. A., Driessen, O., Hermans, J., de Graeff, P. A., Kingma, J. H., van Gilst, W. H., Bel, K., de Langen, C. D. J., Wesselinq, H., Doods, H. N., Davidesko, D., Mathy, M. -J., Batink, H. D., de Jonge, A., Ellenbroek, B., Klockgether, T., Turskit, L., Schwarz, M., Cools, A., Franken, N. A. P., van Delft, J. L., van Langevelde, A., Dubbelman, T. M. A. R., Oosterhuis, J. A., Star, W. M., Marljnissen, J. P. A., Journée-de Korver, J. G., Pauwels, E. K. J., Haenen, G. R. M. M., Bast, A., de Vries, J., Vcrmeulen, N. P. E., Timmerman, H., Hugtenburg, J. G., Beckeringh, J. J., Janssen, B. J. A., Struyker-Boudier, H. A. J., Smits, J. F. N., Jonkman, P. A. M., Man, P. W., Knape, J. T. A., Lambalk, C. B., van Kessel, H., van Rees, G. P., Schoemaker, J., Lammers, J. H. C. M., Meelis, W., Kruk, M. R., van der Poel, A. M., Lippens, F. J. P., van Valkenburg, C. F. M., van der Krogt, J. A., Krick, E. W. C., Belfroid, R. D. M., Noach, E. L., Loesberg, C., Woutersen-v. Nijnanten, F. M. A., Nijkamp, F. P., Molenaar, P. C., Pen, B. S., Polak, R. L., Nievelstein, H. N. M. W., Tijssen, C. M., Smits, J. F. M., Plant jé, J. F., Stoof, J. C., Maikel Kaghoebar, Jan A., Huisman, M., van Ginneken, Cees A. M., Rahusen, F. D., Robillard, G. T., Wildevuur, Ch. R. N., Russel, F. C. M., van der Linden, P. E. M., Vermeulen, W. G., van Ginneken, C. A. M., Smits, R. P. J. H., Steinhusch, H. U. M., Mulder, A. H., ten Brink, E. M. J., van der Plas, J., van Giersbergen, P. L. M., Wlegant, V. M., de Jong, W., van Koppen, C. J., Hermanussen, M. W., Verrijp, C. N., Rodrigues de Miranda, J. F., Beld, A. J., Lammers, J. W. J., van Oosterhout, A. J. M., Vulto, Arnold G., Sharp, Trevor, Ungerstedt, Urban, Wolterink, G., and van Ree, J. M.

Published
1985
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21. Abstracts of papers

Author

Biessels, P. T. M., Agoston, S., Horn, A. S., van Amsterdam, J. G. C., van Buuren, K. J. H., Soudijn, W., Brussee, J., Jansen, A. C. A., Kühn, A., Buhl, T., Rodrigues de Miranda, J. F., Beld, A. J., Lambrecht, G., Mutschler, E., Bultsma, T., Linschoten, M. R., Timmerman, H., Dröge, J. H. M., Wachter, A. A. H., Gaisser, H. D., van der Goot, H., Timnerman, H., Haenen, G. R. M. M., Bast, A., Grünbauer, H. J. M., Hall, David W. R., de Wijn, Spencer R., de Jong, J., de Vries, J., de Klerk, S. J., de Haan, F. H. N., Kelder, J., de Boer, Th., de Graaf, J. S., Wieringa, J. H., Krielaart, M. J., Veenstra, D. M. J., Zuiderveld, O. P., de Mol, N. J., Nieuwenhuyse, Hugo, Koenen, J., Mohn, G. R., Salden, H. J. M., Schonewille, E., Kothuis, M. J. M., Sterk, G. J., van der Schaar, M. W. G., Rademaker, B., van de Straat, R., de Boer, H., Vromans, R. M., Tijms, R. P. J. H., Bosman, P., and Zaagsma, J.

Published
1984
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22. Abstracts of papers

Author

Kleinbloesem, C. H., van Brummelen, P., van de Linde, J. A., Breimer, D. D., Kerremans, A. L. M., Cremers, H. J., Rodrigues de Miranda, J. F., van Ginneken, C. A. M., Gribnau, F. W. J., Schols, M., Mooy, J., van Hooff, M., van Baak, M. A., Rahn, K. H., Soeterboek, A. M., van Thiel, M., Westra, P., Vermeer, G. A., van Rooy, H. H., Pirovano, I. M., Soudijn, W., Lohman, J. J. H. M., Hooymans, P. M., Verhey, M. T. J. M., Pluym, B. F. M., Merkus, F. W. H. M., Thijssen, H. H. W., Baars, L. G., Reijnders, M. J., Wagenvoort, J. H. T., Fieren, M. W. J. A., Goessens, W. H. F., Michel, M. F., Edelbroek, P. M., Zitman, F. G., Schreuder, J. N., Rooymans, H. G. M., de Wolff, F. A., Hekster, Ch. A., Vree, T. B., van Baak, M. A., Jennen, W. H. J., Verstappen, F. T. J., Salemans, J., Lenders, J. W. M., Fennis, J., Thien, Th., Houben, H., Binkhorst, R. A., van 't Laar, A., Koopmans, P. P., van Hees, P. A. M., Hoefnagels, W. H. L., Huysmans, F. T. M., Woittiez, A. J. J., Wenting, G. J., Derkx, F. H. M., Schalekamp, M. A. D. H., Storms, G. E. M. G., Lutterman, J. A., de Nobel, E., van 't Laar, A., Sitsen, J. M. A., de Jong, W., Stuyt, P. M. J., Stalenhoef, A. F. H., Demacker, P. N. M., van 't Laar, A., Oosterhuis, B., Berge, R. J. M.ten, Sauerwein, N. P., Endert, E., Schellekens, P. Th. A., van Boxtel, C. J., Terpstra G. K., Raaijmakers, J. A. M., Wassink, G. A., Kreukniet, J., Bakker, J. C., de Vries-v. Rossen, A., Bleeker, W. K., Ufkes, J. G. R., van Rosevelt, R. F., van Mourik, J. A., Loos, J. A., Brummelhuis, H. G. J., Schalken, J. J., Lammers, J. W. J., Beld, A. J., and van Herwaarden, C. L. A.

Published
1983
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23. Dutch Pharmacological Meeting 1984

Author

Timmerman, H., Koeman, J. H., den Tonkelaar, E. H., Merkus, F. W. H. M., Struyker-Boudier, H. A. J., Bolt, G. R., Saxena, P. R., Bos, R. P., Breed, A. S. P. M., Theuws, J. L. G., Henderson, P. Th., de Brauw, L. M., de Bruijn, E. A., van de Velde, C. J. H., Tjaden, U. R., Kothuis, B. J. L., van Oosterom, A. T., Reeuwijk, H. J. E. M., Pinedo, H. M., van der Hoeven, R., Bultsma, T., Linschoten, M. R., Peter, J., Burbach, H., de Kloet, E. Ronald, Castelein, O., Verbeke, N., Leuven, K. U., Conings, L., Doods, H. N., Kalkman, H. O., de Jonge, A., Wilffert, B., Thoolen, M. J. M. C., Timmermans, P. B. M. W. M., van Zwieten, P. A., van Driel, J. B. M., Klaassen, A. B. M., Kuypers, W., Beld, A. J., Rodrigues de Miranda, J. F., Driessen, O., van der Velde, E. A., Engels, F., Oosting, R. S., Nijkamp, F. P., Evelo, C. T. A., Neis, J. M., Peters, J. G. P., ten Broeke, M. A. M., Vulders, C. A. J. M., Franssen, M. J. A. M., van Herwaarden, C. L. A., van de Putte, L. B. A., Gribnau, F. W. J., van der Graaff, M., Vermeulen, N. P. E., Hofman, P. H., Breimer, D. D., 't Hart, B. J., Wilting, J., de Gier, J. J., Hazelhoff, Bernard, de Vries, Jan B., Oijkstra, Durk, Mulder, Theo, Wynberg, Hans, Horn, Alan, van Doorn, R., Leijdekkers, Ch. -M., Anzion, R., Hengstum, M. v., Festen, J., Buijs, W., Broek, W. v. d., Groothedde, R., Corstens, F., van Heuven-Nolsen, P., de Wildt, D. J., Hillen, F. C., van Noordwijk, J., Janssen, Lambert H. M., Jansen, P. A. F., Meyboom, R. H. B., Vree, T. B., Jelinek, J., Schönbaum, E., Lomax, P., de Jong, W., Sandor, P., Cox van Put, J. J., Jongeneelen, F. J., Leijdekkers, Ch. M., Kerklaan, P. R. M., Zoetemelk, C. E. M., Mohn, G. R., Grote, J. J., Kuijpers, W., Kleinbloesem, C. H., van Brummelen, P., van Harten, J., Koopmans, P. P., Kateman, W., Tan, Y., van Ginneken, C. A. M., van Koppen, C. J., van der Beek, E. M., Lammers, J. W. J., Krielaart, M. J., Laban, E., Charbon, G. A., Folgering, H. Th. M., Lenders, J. W. M., Sluiter, H. E., Willemsen, J., Thien, Th., Mooy, J., Schols, M., Baak, M. v., Hooff, M. v., Rahn, K. H., Mulder, Theo B. A., Grol, Cor J., Dijkstra, Durk, Horn, Alan S., Neef, C., Meijer, D. K. F., van Gemert, P. J. L., Roelofs, H. M. J., Osterhuis, B. O, ten Berge, R. J. M., Schellekens, P. T. A., van Boxtel, C. J., Peeters, P. A. M., Raghoebar, M., Tiemessen, H. L. G. H., Raaijmakers, J. A. M., van Rozen, A. J., Terpstra, G. K., Wassink, G. A., Kreukniet, J., Remeyer, L. R., Reeuwijk, H. J. E., Touw, D. J., Rollema, Hans, Mastebroex, Dora, Russel, F. G. M., Wouterse, A. C., Rijk, M. C. M., Salden, H. J. M., De Schaepdryver, A. F., Lefebvre, R. A., Bogaert, M. G., Scheres, H. M. E., Salden, H. J. H., Siero, H. L. M., Slee, P. H. Th. J., van den Berg, L., Huysmans, F. Th. M., Koene, R. A. P., Smits, J. F. M., Nievelstein, H. M. N., Struyker Boudier, H. A. J., Raaijmakers, J. A. H., Huidekoper, H. J., Thljssen, H. H. W., Baars, L. C. M., Mathy, M. J., Veldhoven, C. M. M., AriËns, E. J., Ruland, C. M., de Vos, Cor, de Graaf, Joop, van Aalst, Gerard, Steenbergen, Hans, Hekster, Y. A., Tijhuis, M. W., Nouws, J. F. M., Wollersheim, H., Fennis, J., van 't Laar, A., Wijnands, W. J., van der Gen, A., Jzerman, A. P. I., Aué, G., Dorlas, R., Krajnc, E. I., Loeber, J. G., van Leeuwen, F. X. R., Wester, P. W., Vos, J. G., Vaessen, H. A. M. G., Heijden, C. A. v. d., Canton, J. H., de Klerk, A., Krajc, E. I., Kruizinga, W., van Ommen, B., Rozing, J., van der Heijden, C. A., van der Voet, G. B., de Wolff, F. A., Edelbroek, Peter M., de Reus, Margot J. H., van den Berg, Tjeerd, and de Wolff, Frederik A.

Published
1984
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24. Abstracts of papers

Author

Rollema, H., Grol, C. J., Feenstra, M. G. P., van Oene, Joop C., Houwing, Hendrik A., Horn, Alan S., Ijzerman, A. P., Bultsma, T., Timmerman, H., Zaagsma, J., van der Graaff, M., Vermeulen, N. P. E., Joeres, R. P., Breimer, D. D., Tsantili-Kakoulidou, A., van der Valk, F., Rekker, R. F., Bijloo, G. J., Zoetemelk, C. E. M., van Hoven, W., van Meeteren-Wālchli, B., van der Gen, A., Mohn, G. R., Buijs, W., Breimer, D. D., Onkenhout, W., de Jong, H. J., Rog, A. A., van Ginneken, C. A. M., Lentjes, E. G. W. M., Bast, A., Savenije-Chapel, E. M., Noordhoek, J., Beld A. J., Rodrigues de Miranda J. F., van Ginneken C. A. M., van der Giesen, W. F., Dröge, J. H. M., Wilting, J., Janssen, L. H. M., van Amsterdam J. G. C., van Buuren, K. J. H., Wijnne, H. J. A., Nolet, M. R. A., Kremer, J. M. H., Bakker, G., van der Heijden, P. J. C. M., van der Schaar, M. W. G., Bank, C. M. C., Eriks, J. Ch., Gaisser, H. -D., van der Goot, H., Sterk, G. J., Zaagsma, J., Lock, F. M., de Vries, J., Mullink, H., van Bree, L., Redegeld, F. A. M., Grolleman, C. W. J., de Visser, A. C., Wolke, J. G. C., Buchan, P., and Burns, J. W.

Published
1982
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25. Abstracts of papers

Author

Wesseling, H., Veur, E. v. d., Berge, B. S. ten, Donker, A. J. M., May, J. F., Schuurman, F. H., van Schaik, B. A. M., Geyskes, G. G., Petri, H., Böhm, R., Mooy, J., van Kemenade, J., van Baak, M., Rahn, K. H., van Heereveld, H. A. E. M., Wollersheim, H., Thien, Th., Lammers, J. W. J., Folgering, H. Th. M., van Herwaarden, C. L. A., Graafsma, S. J., Snijders, P. J. F., de Miranda, J. F. Rodrigues, de Bruijn, E. A., van Oosterom, A. T., Kuppen, P. J. K., Jol, C., Tjaden, U. R., Trimbos, J. B., Runhaar, E. A., Nooij, H. A., van de Loo, A. A. J., Speth, P. A. J., Linssen, P. C. M., Haanen, C., Leeuwenkamp, O. R., Neyt, J. H., van der Vijgh, W. J. F., Pinedo, H. M., Schellens, J. H. M., Danhof, M., Breimer, D. D., Overdiek, J. W. P. M., Merkus, F. W. H. M., Teeuwen, H. W. A., de Schepper, P., Tjandramaga, T. B., van Rossum, J. M., Tukker, J. J., Blankenstein, M. A., Nortier, J. W. R., Zantvoort, F. A., Wagonvoort, J. H. T., Derkx, F. H. M., Michel, M. F., Wijnands, W. J. A., Baars, A. M., Vree, T. B., van Dalen, R., Termond, E. S. F., Boekema, P., Smits, P., de Abreu, R., Thlen, Th., van 't Laar, A., Böhm, R. O. B., Arends, B. G., van Hooff, H. E. J., van Baak, M. A., Derkx F., Tan-Tjiong H., Wenting G., Manin't Veld A., Schalekamp M., van Harten, J., van Brummelen, P., Danhof, H., Lodewijks, M. Th. M., Jansen, P. A. F., van Ginneken, C. A. M., Gribnau, F. W. J., Lohman, J. J. H. M., Hooymans, P. M., Merkus, F. W. H. H., Mol, M. J. T. M., Stalenhoef, A. F. H., Demacker, P. N. M., van't Laar, A., Raaijmakers, J. A. M., Terpstra, G. K., and Holdrinet, R. S. G.

Published
1986
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26. Binding and functional properties of hexocyclium and sila-hexocyclium derivatives to muscarinic receptor suhtypes

Author

Waelbroeck, Magall, Camus, Jean, Tastenoy, Michèle, Feifel, Roland, Mutschler, Ernst, Tacke, Reinhold, Carsten Strohmann, Rafeiner, Klaus, Rodrigues Miranda, J. F., and Lambrecht, Günter

Subjects
ddc:546
Abstract

1 We have compared the binding properties of several hexocyclium and sila-hexocyclium derivatives to muscarinic Ml receptors (in rat brain, human neuroblastoma (NB-OK I) cells and calf superior cervical ganglia), rat heart M2 receptors, rat pancreas M3 receptors and M4 receptors in rat striatum, with their functional antimuscarinic properties in rabbit vas deferens (Ml/M4-like), guinea-pig atria (M2), and guinea-pig ileum (M3) muscarinic receptors. 2 Si la-substitution (C/Si exchange) of hexocyclium (~ sila-hexocyclium) and demethyl-hexocyclium (~demethyl-sila-hexocyclium) did not significantly affect their affinities for muscarinic receptors. By contrast, sila-substitution of demethoxy-hexocyclium increased its affinity 2 to 3 fold for all the muscarinic receptor subtypes studied. 3 The p-fluoro- and p-chloro-derivatives of sila-hexocyclium had lower affinities than the parent compound at the four receptor subtypes, in binding and pharmacological studies. 4 In binding studies, o-methoxy-sila-hexocyclium (Ml = M4 ~ M3 ~ M2) had a much lower affinity than sila-hexocyclium for the four receptor subtypes, and discriminated the receptor subtypes more poorly than sila-hexocyclium (Ml = M3> M4> M2)' This is in marked contrast with the very clear selectivity of demethoxy-sila-hexocyclium for the prejunctional MtlM4-like heteroreceptors in rabbit vas deferens. 5 The tertiary amines demethyl-hexocyclium, demethyl-sila-hexocyclium and demethyl-o-methoxy-silahexocyclium had 10 to 30 fold lower affinities than the corresponding quaternary ammonium derivatives.

Published
1994

27. Selective labelling of muscarinic M\(_1\) receptors in calf superior cervical ganglia by [\(^3\)H](\(\pm\))-telenzepine

Author

Feifel, R., Rodrigues de Miranda, J. F., Strohmann, C., Tacke, Reinhold, Aasen, A. J., Mutschler, E., and Lambrecht, G.

Subjects
ddc:540, Anorganische Chemie
Abstract

A method was developed to detennine the affinities of antimuscarinic drugs at M\(_1\) receptors. [\(^3\)H](±)-Telenzepine served as radioligand in crude preparations of calf superior cervical ganglia and showed high affinity for a single receptor population. consisting of M1 receptors (K\(_D\) = 1.12 nM). Kinetic experiments showed monophasic association (k\(_1\) =0.017 min\(^{-1}\) nM\(^{-1}\) ) and dissociation (k\(_1\) = 0.017 min\(^{-1}\) ) kinetics, the half-life of dissociation being 41 min at 37°C. The kinetie K\(_D\) value amounted to 1.00 nM. M\(_1\) affinities for pirenzepine, methoctramine. hexahydro-sila-difenidol and p-fluoro-hexahydro-sila-difenidol detennined in competition experiments were similar to those found in functional studies with MI receptors in rabbit isolated vas deferens. The binding assay was used to deterriline the affinities of the (R) and (S) enantiomers of tertiary (trihexyphenidyl, hexahydro-difenidol. hexbutinol, p-fluoro-hexbutinol) and quatemary musearlnie antagonists (trihexyphenidyl methiodide. hexbutinol methiodide). Comparison of results obtained with the rabbit vas deferens suggested that the ionic environment may influence the affinities.

Published
1991

35. Beta adrenoceptor binding and induced relaxation in airway smooth muscle from patients with chronic airflow obstruction.

Author

van Koppen, C J, de Miranda, J F, Beld, A J, van Herwaarden, C L, Lammers, J W, and van Ginneken, C A

Abstract

Beta adrenoceptor function in central airway smooth muscle of patients with chronic airflow obstruction was investigated by radioligand binding studies and isoprenaline relaxation experiments. Receptor characteristics were determined in tracheal smooth muscle preparations obtained at necropsy from 12 patients and in bronchial tissue obtained at thoracototomy from 21 patients with chronic airflow obstruction. Receptor characteristics were compared with those obtained in airway tissue preparations from 65 control subjects without chronic airflow obstruction. The number of beta adrenoceptors, their binding affinity for the radioligand [125I]-(-)-cyanopindolol, and the tissue binding characteristics of isoprenaline were similar in tissue from patients with chronic airflow obstruction and from control subjects. Isoprenaline induced relaxation of tracheal smooth muscle without precontraction by methacholine showed slightly (though not significantly) less sensitivity to isoprenaline in patients with chronic airflow obstruction than in control subjects (mean (SEM) pD2--the negative logarithm of the concentration producing 50% relaxation--6.32 (0.16) v 6.62 (0.15)). The same pattern of pD2 values was found in segmental bronchial strips without precontraction by methacholine (chronic airflow obstruction 6.55 (0.27), control 7.14 (0.12)). Isoprenaline relaxation in segmental bronchial strips when contracted maximally was significantly less in the patients with airflow obstruction than in the control subjects (pD2 value 5.99 (0.18) v 6.45 (0.07)). These results suggest that beta adrenoceptors in airway smooth muscle of patients with chronic airflow obstruction are not abnormal in number or in binding affinity but that there is less effective coupling between components of the relaxant system distal to the beta adrenoceptor. The possibility that the reduced isoprenaline sensitivity is a consequence of previous bronchodilator treatment cannot be excluded. [ABSTRACT FROM PUBLISHER]

Published
1989

37. Autoradiographic visualization of muscarinic receptors in human bronchi.

Author

van Koppen, C J, Blankesteijn, W M, Klaassen, A B, Rodrigues de Miranda, J F, Beld, A J, and van Ginneken, C A

Abstract

To visualize muscarinic receptors in human bronchi, the stripping film method was used which permits direct autoradiographic localization of tissue labeling. Cryostate sections of human bronchi were fixed in 0.5% glutaraldehyde in Krebs-Ringer buffer, pH 7.0 for 30 min at 0 degrees C, washed in Krebs-Ringer buffer for 20 min at 0 degrees C and incubated with (-)-[3H]Quinuclidinyl benzilate [(-)-[3H]QNB] for 90 min at 37 degrees C. Specific (-)-[3H]QNB binding to tissue sections was saturable (receptor density of 0.14 +/- 0.03 fmol/tissue section) and of high affinity (Kd of 40 +/- 9 pM). For autoradiography, labeled tissue sections were covered with stripping film and exposed for 5 months. Muscarinic receptors in human bronchi were located predominantly in submucosal glands and parasympathetic ganglia. There was less labeling in smooth muscle cells and nerve bundles. Epithelium and blood vessels located within the bronchial wall were devoid of specific labeling.

Published
1988

41. Demonstration of Alpha1-Adrenoceptors in Rat Nasal Mucosa

Author

van Megen, Y. J. B., Klaassen, A. B. M., de Miranda, J. F. Rodrigues, Wentges, R. Th.R., and van Ginneken, C. A. M.

Abstract

3H-Prazosin was used to demonstrate Alpha1-adrenoceptors in rat nasal mucosa. Specific binding is saturable and occurs to a homogeneous class of binding sites with high affinity (Kd=0.07 + 0.01 nmol/l and with a receptor density of 0.36 ± 0.02 pmo1/g tissue or 14 ± 1 fmol/mg protein. Kinetic experiments resulted in a Kd-value of 0.03 nmol/l. The binding is stereoselectively inhibited by epinephrine enantiomers. The antagonist prazosin inhibits 3H-Prazosin binding with high affinity, in contrast to yohimbine, classifying the binding sites as Alpha1-adrenoceptors. Inhibition experiments with WB4101 indicated the presence of Alpha1 a- (31 ± 9%) and Alpha1b-adrenoceptor subtypes in the rat nasal mucosa. The order of potencies of agonists determined in competition experiments was (-)epinephrine > (+)epinephrine > (-)phenylephrine.

Published
1989
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42. Kinetics of (-)125Iodocyanopindolol Binding to Intact Human Mononuclear Cells

Author

Graafsma, S. J., van Tits, L. J. H., de Miranda, J. F. Rodrigues, and Thien, T.

Abstract

In association experiments of (-)125Iodocyanopindolol (125ICYP) with human mononuclear cells (MNC) at 70 pM and a temperature of 37°C equilibrium was reached within 30 min. However, when the same experiments were performed at a concentration of 4 pM 125ICYP, equilibrium was only reached after 3 hours. The consequences of incomplete equilibrium for the interpretation of binding experiments under the incorrect assumption that equilibrium has been reached, was investigated at equilibration times of one, two and three hours. The dissociation constant, Kd, decreased from 7.4 ± 0.2 pM after one hour to 2.5 ± 0.4 pM after three hours of incubation while the receptor density, Ro, decreased from 970 ± 170 to 713 ± 58 sites/cell. Analysis of computer simulated binding curves confirmed the decrease in Kd and Ro at prolonged incubations. We conclude that in 125ICYP binding in intact MNC one hour of incubation is not sufficient to obtain equilibrium at the lower concentrations. This leads to an overestimation of Kd- and to a lesser extent of Ro-values. Extending the incubation time to three hours on the other hand may lead to a loss of cells and therefore to an underestimation of Ro.

Published
1988
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43. Does treatment with beta-adrenergic blocking agents cause a decrease in beta2-adrenoceptor affinity?

Author

Blankesteijn, W. M., Graafsma, S. J., Hectors, M. P. C., Olde Riekerink, E. A. M., Rodrigues de Miranda, J. F., and Thien, Th.

Abstract

The effect of ß-adrenoceptor antagonists (BAAs) differing in lipophilicity and partial agonist activity (PAA), and a full agonist, on the dissociation constant for [125I]-(-)- iodocyanopindolol binding to ß2-adrenoceptors (KD) has been investigated.

Published
1992
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44. Pharmacokinetic properties of the antimuscarinic drug [3H]-hexahydro-sila-difenidol in the rat

Author

Rettenmayr, N. M., Miranda, J. F., Rijntjes, N. V. M., Russel, F. G. M., Ginneken, C. A. M., Strohmann, C., Tacke, R., Lambrecht, G., and Mutschler, E.

Abstract

The pharmacokinetics of tritiated hexahydrosila-difenidol ([3H]-HHSiD) were examined in rats. Furthermore, the distribution of radioactivity was studied by means of whole body autoradiography.

Published
1990
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45. A method for the quantitative determination of the total concentration of radiopaque agents in plasma

Author

DE MIRANDA, J F RODRIGUES, PETERS, J C M, and VAN RENS, A M F P

Abstract

The total concentration of radiopaque agents in plasma can be determined spectrophotometrically after elimination of interfering factors using a double column filled with cross-linked dextran-gel Sephadex G-25c and Se-Sephadex 25c. The method gives a linear relationship between the total concentration in the sample and the maximum concentration in the eluate and is sensitive to about 50μg/ml of radiopaque agent.

Published
1967
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46. In COVID-19 health messaging, loss framing increases anxiety with little-to-no concomitant benefits: Experimental evidence from 84 countries

Author

Dorison, C. A., Lerner, J. S., Heller, B. H., Rothman, A. J., Kawachi, I. I., Wang, K., Rees, V. W., Gill, B. P., Gibbs, N., Ebersole, C. R., Vally, Z., Tajchman, Z., Zsido, A. N., Zrimsek, M., Chen, Z., Ziano, I., Gialitaki, Z., Ceary, C. D., Jang, Y., Lin, Y., Kunisato, Y., Yamada, Y., Xiao, Q., Jiang, X., Du, X., Yao, E., Ryan, W., Wilson, J. P., Cyrus-Lai, W., Jimenez-Leal, W., Law, W., Unanue, W., Collins, W. M., Richard, K. L., Vranka, M., Ankushev, V., Schei, V., DePaola, C., Lerche, V., Kovic, V., Križanić, V., Kadreva, V. H., Adoric, V. C., Tran, U. S., Yeung, S. K., Hassan, W., Houston, R., Machin, M. A., Lima, T. J. S., Ostermann, T., Frizzo, T., Sverdrup, T. E., House, T., Gill, T., Fedotov, M., Paltrow, T., Jernsäther, T., Rahman, T., Machin, T., Koptjevskaja-Tamm, M., Hostler, T. J., Ishii, T., Szaszi, B., Adamus, S., Suter, L., von Bormann, S. M., Habib, S., Studzinska, A., Stojanovska, D., Janssen, S. M. J., Stieger, S., Schulenberg, S. E., Tatachari, S., Azouaghe, S., Sorokowski, P., Sorokowska, A., Song, X., Morbée, S., Lewis, S. C., Sinkolova, S., Grigoryev, D., Drexler, S. M., Daches, S., Levine, S. L., Geniole, S. N., Akter, S., Vračar, S., Massoni, S., Costa, S., Zorjan, S., Sarıoğuz, E., Morales Izquierdo, S., Tshonda, S. S., Alves, S. G., Pöntinen, S., Álvarez Solas, S., Ordoñez-Riaño, S., Batić Očovaj, S., Onie, S., Lins, S., Biberauer, T., Çoksan, S., Khumkom, S., Sacakli, A., Ruiz-Fernández, S., Geiger, S. J., FatahModares, S., Walczak, R. B., Betlehem, R., Vilar, R., Doekemeijer, R., Cárcamo, R., Ross, R. M., McCarthy, R., Ballantyne, T., Westgate, E. C., Gargurevich, R., Afhami, R., Ren, D., Monteiro, R. P., Reips, U-D., Reggev, N., Calin-Jageman, R. J., Pourafshari, R., London, R., Oliveira, R., Nedelcheva-Datsova, M., Rahal, R-M., Ribeiro, R. R., Radtke, T., Searston, R., Jai-ai, R., Habte, R., Zdybek, P., Chen, S-C., Wajanatinapart, P., Maturan, P. L. G., Perillo, J. T., Isager, P. M., Kačmár, P., Macapagal, P. M., Maniaci, M. R., Szwed, P., Hanel, P. H. P., Forbes, P. A. G., Arriaga, P., Paris, B., Parashar, N., Papachristopoulos, K., Sebastián-Correa, P., Kácha, O., Bernardo, M., Campos, O., Niño Bravo, O., Galindo-Caballero, O. J., Ogbonnaya, C. E., Bialobrzeska, O., Kiselnikova, N., Simonovic, N., Cohen, N., Nock, N. L., Hernandez, A., Thogersen-Ntoumani, C., Ntoumanis, N., Johannes, N., Albayrak-Aydemir, N., Say, N., Neubauer, A. B., Martin, N. I., Torunsky, N., van Antwerpen, N., Van Doren, N., Sunami, N., Rachev, N. R., Majeed, N. M., Schmidt, N-D., Nadif, K., Corral-Frías, N. S., Ouherrou, N., Abbas, N., Pantazi, M., Lucas, M. Y., Vasilev, Martin R., Ortiz, M. V., Butt, M. M., Kurfali, M., Kabir, M., Muda, R., Tejada Rivera, M. C., Sirota, M., Seehuus, M., Parzuchowski, M., Toro, M., Hricova, M., Alarcón Maldonado, M., Rentzelas, P., Vansteenkiste, M., Metz, M. A., Marszalek, M., Karekla, M., Mioni, G., Bosma, M. J., Westerlund, M., Vdovic, M., Bialek, M., Silan, M. A., Anne, M., Misiak, M., Gugliandolo, M. C., Grinberg, M., Capizzi, M., Espinoza Barría, M. F., Kurfali, M. A., Mensink, M. C., Harutyunyan, M., Khosla, M., Dunn, M. R., Korbmacher, M., Adamkovič, M., Ribeiro, M. F. F., Terskova, M., Hruška, M., Martončik, M., Jansen, M., Voracek, M., Čadek, M., Frias-Armenta, M., Kowal, M., Topor, M., Roczniewska, M., Oosterlinck, M., Braun Kohlová, M., Paruzel-Czachura, M., Sabristov, M., Romanova, M., Papadatou-Pastou, M., Lund, M. L., Antoniadi, M., Magrin, M. E., Jones, M. V., Ortiz, M. S., Manavalan, M., Muminov, A., Kossowska, M., Friedemann, M., Wielgus, M., van Hooff, M. L. M., Varella, M. A. C., Standage, M., Nicolotti, M., Colloff, M. F., Bradford, M., Vaughn, L. A., Eudave, L., Vieira, L., Sanabria Pineda, L. M., Matos, L., Calderón Pérez, L., Lazarevic, L. B., Jaremka, L. M., Smit, E. S., Kushnir, E., Ferguson, L. J., Anton-Boicuk, L., Lins de Holanda Coelho, G., Ahlgren, L., Liga, F., Levitan, C. A., Micheli, L., Gunton, L-A., Volz, L., Stojanovska, M., Boucher, L., Samojlenko, L., Javela Delgado, L. G., Kaliska, L., Labadi, B., Warmelink, L., Rojas-Berscia, L. M., Yu, K., Wylie, K., Wachowicz, J., Desai, K., Barzykowski, K., Kozma, L., Evans, K., Kirgizova, K., Agesin, B. E., Koehn, M. A., Wolfe, K., Korobova, T., Morris, K., Klevjer, K., van Schie, K., Vezirian, K., Damnjanović, K., Krabbe Thommesen, K., Schmidt, K., Filip, K., Staniaszek, K., Grzech, K., Hoyer, K., Moon, K., Khaobunmasiri, S., Rana, K., Janjić, K., Suchow, J. W., Kielińska, J., Cruz Vásquez, J. E., Chanal, J., Beitner, J., Vargas-Nieto, J. C., Roxas, J. C. T., Taber, J., Urriago-Rayo, J., Pavlacic, J. M., Benka, J., Bavolar, J., Soto, J. A., Olofsson, J. K., Vilsmeier, J. K., Messerschmidt, J., Czamanski-Cohen, J., Waterschoot, J., Moss, J. D., Boudesseul, J., Lee, J. M., Kamburidis, J., Joy-Gaba, J. A., Zickfeld, J., Miranda, J. F., Verharen, J. P. H., Hristova, E., Beshears, J. E., Đorđević, J. M., Bosch, J., Valentova, J. V., Antfolk, J., Berkessel, J. B., Schrötter, J., Urban, J., Röer, J. P., Norton, J. O., Silva, J. R., Pickering, J. S., Vintr, J., Uttley, J., Kunst, J. R., Ndukaihe, I. L. G., Iyer, A., Vilares, I., Ivanov, A., Ropovik, I., Sula, I., Sarieva, I., Metin-Orta, I., Prusova, I., Pinto, I., Bozdoc, A. I., Almeida, I. A. T., Pit, I. L., Dalgar, I., Zakharov, I., Arinze, A. I., Ihaya, K., Stephen, I. D., Gjoneska, B., Brohmer, H., Flowe, H., Godbersen, H., Kocalar, H. E., Hedgebeth, M. V., Chuan-Peng, H., Sharifian, M. H., Manley, H., Akkas, H., Hajdu, N., Azab, H., Kaminski, G., Nilsonne, G., Anjum, G., Travaglino, G. A., Feldman, G., Pfuhl, G., Czarnek, G., Marcu, G. M., Hofer, G., Banik, G., Adetula, G. A., Bijlstra, G., Verbruggen, F., Kung, F. Y. H., Martela, F., Foroni, F., Forest, J., Singer, G., Muchembled, F., Azevedo, F., Mosannenzadeh, F., Marinova, E., Štrukelj, E., Etebari, Z., Baskin, E., Garcia, E. O. L., Musser, E., van Steenkiste, I. M. M., Bradshaw, E. L., Ahn, E. R., Quested, E., Pronizius, E., Jackson, E. A., Manunta, E., Agadullina, E., Šakan, D., Dursun, P., Dujols, O., Dubrov, D., Willis, M., Tümer, M., Beaudry, J. L., Popović, D., Dunleavy, D., Djamai, I., Krupić, D., Herrera, D., Vega, D., Du, H., Mola, D., Chakarova, D., Davis, W. E., Holford, D. L., Lewis, D. M. G., Vaidis, D. C., Hausman Ozery, D., Zambrano Ricaurte, D., Storage, D., Sousa, D., Serrato Alvarez, D., Boller, D., Dalla Rosa, A., Dimova, D., Marko, D., Moreau, D., Reeck, C., Correia, R. C., Whitt, C. M., Lamm, C., Singh Solorzano, C., von Bastian, C.C., Sutherland, C. A. M., Overkott, C., Aberson, C. L., Wang, C., Niemiec, C. P., Reimer, C., Karashiali, C., Noone, C., Chiu, F., Picciocchi, C., Eben, C., Brownlow, C., Karaarslan, C., Cellini, N., Esteban-Serna, C., Reyna, C., Ferreyra, C., Batres, C., Li, R., Grano, C., Carpentier, J., Tamnes, C. K., Fu, C. H. Y., Ishkhanyan, B., Bylinina, L., Jaeger, B., Bundt, C., Bulut Allred, T., Vermote, B. J., Bokkour, A., Bogatyreva, N., Shi, J., Chopik, W. J., Antazo, B., Becker, M., Bayyat, M. M., Cocco, B., Chou, W-L., Barkoukis, V., Aczel, B., Baklanova, E., Bai, H., Balci, B. B., Babinčák, P., Soenens, B., Dixson, B. J. W., Mokady, A., Kappes, H. B., Atari, M., Szala, A., Szabelska, A., Aruta, J. J. B., Domurat, A., Arinze, N. C., Modena, A., Adiguzel, A., Monajem, A., El Arabi, K. A., Özdoğru, A. A., Rothbaum, A. O., Torres, A. J. O., Theodoropoulou, A., Skowronek, A., Jurković, A. P., Singh, A., Kassianos, A. P., Findor, A., Hartanto, A., Thibault Landry, A., Ferreira, A., Caetano Santos, A., De la Rosa-Gomez, A., Gourdon-Kanhukamwe, A., Luxon, A. M., Todsen, A. L., Karababa, A., Janak, A., Pilato, A., Bran, A., Tullett, A. M., Kuzminska, A. O., Krafnick, A. J., Urooj, A., Khaoudi, A., Ahmed, A., Groyecka-Bernard, A., Askelund, A. D., Adetula, A., Belaus, A., Charyate, A. C., Wichman, A. L., Stoyanova, A., Greenburgh, A., Thomas, A. G., Arvanitis, A., Forscher, P. S., Mallik, P. R., Primbs, M. A., Miller, J. K., Moshontz, H., Urry, H. L., IJzerman, H., Basnight-Brown, D. M., Chartier, C. R., Buchanan, E. M., Coles, N. A., Dorison, C. A., Lerner, J. S., Heller, B. H., Rothman, A. J., Kawachi, I. I., Wang, K., Rees, V. W., Gill, B. P., Gibbs, N., Ebersole, C. R., Vally, Z., Tajchman, Z., Zsido, A. N., Zrimsek, M., Chen, Z., Ziano, I., Gialitaki, Z., Ceary, C. D., Jang, Y., Lin, Y., Kunisato, Y., Yamada, Y., Xiao, Q., Jiang, X., Du, X., Yao, E., Ryan, W., Wilson, J. P., Cyrus-Lai, W., Jimenez-Leal, W., Law, W., Unanue, W., Collins, W. M., Richard, K. L., Vranka, M., Ankushev, V., Schei, V., DePaola, C., Lerche, V., Kovic, V., Križanić, V., Kadreva, V. H., Adoric, V. C., Tran, U. S., Yeung, S. K., Hassan, W., Houston, R., Machin, M. A., Lima, T. J. S., Ostermann, T., Frizzo, T., Sverdrup, T. E., House, T., Gill, T., Fedotov, M., Paltrow, T., Jernsäther, T., Rahman, T., Machin, T., Koptjevskaja-Tamm, M., Hostler, T. J., Ishii, T., Szaszi, B., Adamus, S., Suter, L., von Bormann, S. M., Habib, S., Studzinska, A., Stojanovska, D., Janssen, S. M. J., Stieger, S., Schulenberg, S. E., Tatachari, S., Azouaghe, S., Sorokowski, P., Sorokowska, A., Song, X., Morbée, S., Lewis, S. C., Sinkolova, S., Grigoryev, D., Drexler, S. M., Daches, S., Levine, S. L., Geniole, S. N., Akter, S., Vračar, S., Massoni, S., Costa, S., Zorjan, S., Sarıoğuz, E., Morales Izquierdo, S., Tshonda, S. S., Alves, S. G., Pöntinen, S., Álvarez Solas, S., Ordoñez-Riaño, S., Batić Očovaj, S., Onie, S., Lins, S., Biberauer, T., Çoksan, S., Khumkom, S., Sacakli, A., Ruiz-Fernández, S., Geiger, S. J., FatahModares, S., Walczak, R. B., Betlehem, R., Vilar, R., Doekemeijer, R., Cárcamo, R., Ross, R. M., McCarthy, R., Ballantyne, T., Westgate, E. C., Gargurevich, R., Afhami, R., Ren, D., Monteiro, R. P., Reips, U-D., Reggev, N., Calin-Jageman, R. J., Pourafshari, R., London, R., Oliveira, R., Nedelcheva-Datsova, M., Rahal, R-M., Ribeiro, R. R., Radtke, T., Searston, R., Jai-ai, R., Habte, R., Zdybek, P., Chen, S-C., Wajanatinapart, P., Maturan, P. L. G., Perillo, J. T., Isager, P. M., Kačmár, P., Macapagal, P. M., Maniaci, M. R., Szwed, P., Hanel, P. H. P., Forbes, P. A. G., Arriaga, P., Paris, B., Parashar, N., Papachristopoulos, K., Sebastián-Correa, P., Kácha, O., Bernardo, M., Campos, O., Niño Bravo, O., Galindo-Caballero, O. J., Ogbonnaya, C. E., Bialobrzeska, O., Kiselnikova, N., Simonovic, N., Cohen, N., Nock, N. L., Hernandez, A., Thogersen-Ntoumani, C., Ntoumanis, N., Johannes, N., Albayrak-Aydemir, N., Say, N., Neubauer, A. B., Martin, N. I., Torunsky, N., van Antwerpen, N., Van Doren, N., Sunami, N., Rachev, N. R., Majeed, N. M., Schmidt, N-D., Nadif, K., Corral-Frías, N. S., Ouherrou, N., Abbas, N., Pantazi, M., Lucas, M. Y., Vasilev, Martin R., Ortiz, M. V., Butt, M. M., Kurfali, M., Kabir, M., Muda, R., Tejada Rivera, M. C., Sirota, M., Seehuus, M., Parzuchowski, M., Toro, M., Hricova, M., Alarcón Maldonado, M., Rentzelas, P., Vansteenkiste, M., Metz, M. A., Marszalek, M., Karekla, M., Mioni, G., Bosma, M. J., Westerlund, M., Vdovic, M., Bialek, M., Silan, M. A., Anne, M., Misiak, M., Gugliandolo, M. C., Grinberg, M., Capizzi, M., Espinoza Barría, M. F., Kurfali, M. A., Mensink, M. C., Harutyunyan, M., Khosla, M., Dunn, M. R., Korbmacher, M., Adamkovič, M., Ribeiro, M. F. F., Terskova, M., Hruška, M., Martončik, M., Jansen, M., Voracek, M., Čadek, M., Frias-Armenta, M., Kowal, M., Topor, M., Roczniewska, M., Oosterlinck, M., Braun Kohlová, M., Paruzel-Czachura, M., Sabristov, M., Romanova, M., Papadatou-Pastou, M., Lund, M. L., Antoniadi, M., Magrin, M. E., Jones, M. V., Ortiz, M. S., Manavalan, M., Muminov, A., Kossowska, M., Friedemann, M., Wielgus, M., van Hooff, M. L. M., Varella, M. A. C., Standage, M., Nicolotti, M., Colloff, M. F., Bradford, M., Vaughn, L. A., Eudave, L., Vieira, L., Sanabria Pineda, L. M., Matos, L., Calderón Pérez, L., Lazarevic, L. B., Jaremka, L. M., Smit, E. S., Kushnir, E., Ferguson, L. J., Anton-Boicuk, L., Lins de Holanda Coelho, G., Ahlgren, L., Liga, F., Levitan, C. A., Micheli, L., Gunton, L-A., Volz, L., Stojanovska, M., Boucher, L., Samojlenko, L., Javela Delgado, L. G., Kaliska, L., Labadi, B., Warmelink, L., Rojas-Berscia, L. M., Yu, K., Wylie, K., Wachowicz, J., Desai, K., Barzykowski, K., Kozma, L., Evans, K., Kirgizova, K., Agesin, B. E., Koehn, M. A., Wolfe, K., Korobova, T., Morris, K., Klevjer, K., van Schie, K., Vezirian, K., Damnjanović, K., Krabbe Thommesen, K., Schmidt, K., Filip, K., Staniaszek, K., Grzech, K., Hoyer, K., Moon, K., Khaobunmasiri, S., Rana, K., Janjić, K., Suchow, J. W., Kielińska, J., Cruz Vásquez, J. E., Chanal, J., Beitner, J., Vargas-Nieto, J. C., Roxas, J. C. T., Taber, J., Urriago-Rayo, J., Pavlacic, J. M., Benka, J., Bavolar, J., Soto, J. A., Olofsson, J. K., Vilsmeier, J. K., Messerschmidt, J., Czamanski-Cohen, J., Waterschoot, J., Moss, J. D., Boudesseul, J., Lee, J. M., Kamburidis, J., Joy-Gaba, J. A., Zickfeld, J., Miranda, J. F., Verharen, J. P. H., Hristova, E., Beshears, J. E., Đorđević, J. M., Bosch, J., Valentova, J. V., Antfolk, J., Berkessel, J. B., Schrötter, J., Urban, J., Röer, J. P., Norton, J. O., Silva, J. R., Pickering, J. 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Abstract

The COVID-19 pandemic (and its aftermath) highlights a critical need to communicate health information effectively to the global public. Given that subtle differences in information framing can have meaningful effects on behavior, behavioral science research highlights a pressing question: Is it more effective to frame COVID-19 health messages in terms of potential losses (e.g., “If you do not practice these steps, you can endanger yourself and others”) or potential gains (e.g., “If you practice these steps, you can protect yourself and others”)? Collecting data in 48 languages from 15,929 participants in 84 countries, we experimentally tested the effects of message framing on COVID-19-related judgments, intentions, and feelings. Loss- (vs. gain-) framed messages increased self-reported anxiety among participants cross-nationally with little-to-no impact on policy attitudes, behavioral intentions, or information seeking relevant to pandemic risks. These results were consistent across 84 countries, three variations of the message framing wording, and 560 data processing and analytic choices. Thus, results provide an empirical answer to a global communication question and highlight the emotional toll of loss-framed messages. Critically, this work demonstrates the importance of considering unintended affective consequences when evaluating nudge-style interventions.

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