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3. Screening for Excessive Gambling Behaviors on the Internet (EDEIN)

Author

Université de Nantes, ODJ (Observatoire des Jeux), ARJEL (Autorité de Régulation des Jeux En Ligne), MILDECA (Mission Interministérielle de Lutte contre les Drogues Et les Conduites Addictives), University of Paris 13, and Institut de Recherche en Santé Publique, France

Published
2020

4. Predicting depression onset in young people based on clinical, cognitive, environmental, and neurobiological data

Author

Yara J. Toenders, Akhil Kottaram, Richard Dinga, Christopher G. Davey, Tobias Banaschewski, Arun L.W. Bokde, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Tomáš Paus, Luise Poustka, Sarah Hohmann, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Argyris Stringaris, Betteke van Noort, Jani Penttilä, Yvonne Grimmer, Corinna Insensee, Andreas Becker, Gunter Schumann, Lianne Schmaal, Developmental Neuroscience in Society, University of Melbourne, Radboud University [Nijmegen], Heidelberg University, Trinity College Dublin, King‘s College London, Universität Mannheim, Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), University of Vermont [Burlington], University of Nottingham, UK (UON), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Physikalisch-Technische Bundesanstalt [Braunschweig] (PTB), Trajectoires Développementales en Psychiatrie [Paris], Université Paris Descartes - Paris 5 (UPD5)-PRES Sorbonne Paris Cité-Institut National de la Santé et de la Recherche Médicale (INSERM), CB - Centre Borelli - UMR 9010 (CB), Service de Santé des Armées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-Université Paris Cité (UPCité), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Kiel University, Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), University of Toronto, University Medical Center Göttingen (UMG), Technische Universität Dresden = Dresden University of Technology (TU Dresden), National Institute of Mental Health (NIMH), Leibniz Institute for Neurobiology [Magdeburg] (LIN), Fudan University [Shanghai], This work was supported by the MQ Brighter Futures Award (MQBFC/2 [to LS]), the National Institute of Mental Health of the National Institutes of Health (Award Number R01MH117601 [to LS]), a National Health and Medical Research Council (NHMRC) Career Development Fellowship (1140764 [to LS]), the Dame Kate Campbell Fellowship from the Faculty of Medicine, Dentistry and Health Sciences at The University of Melbourne, and an NHMRC Career Development Award (141738 [to CGD]).This work received support from the following sources: the European Union–funded FP6 Integrated Project IMAGEN (Reinforcement-related behavior in normal brain function and psychopathology) (LSHM-CT-2007-037286), the Horizon 2020–funded ERC Advanced Grant 'STRATIFY' (Brain network based stratification of reinforcement-related disorders) (695313), Human Brain Project (HBP SGA 2, 785907, and HBP SGA 3, 945539), the Medical Research Council Grant 'c-VEDA' (Consortium on Vulnerability to Externalizing Disorders and Addictions) (MR/N000390/1), the National Institutes of Health (NIH) (R01DA049238, A decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers), the National Institute for Health Research Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London, the Bundesministerium für Bildung und Forschung (BMBF Grant Nos. 01GS08152, 01EV0711, Forschungsnetz AERIAL 01EE1406A, 01EE1406B, Forschungsnetz IMAC-Mind 01GL1745B), the Deutsche Forschungsgemeinschaft (DFG Grant Nos. SM 80/7-2, SFB 940, TRR 265, NE 1383/14-1), the Medical Research Foundation and Medical Research Council (Grant Nos. MR/R00465X/1 and MR/S020306/1), and the NIH-funded ENIGMA (Grant Nos. 5U54EB020403-05 and 1R56AG058854-01). Further support was provided by grants from the ANR (ANR-12-SAMA-0004, AAPG2019 – GeBra), the Eranet Neuron (AF12-NEUR0008-01 – WM2NA, and ANR-18-NEUR00002-01 – ADORe), the Fondation de France (00081242), the Fondation pour la Recherche Médicale (DPA20140629802), the Mission Interministérielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA), the Assistance-Publique-Hôpitaux-de-Paris and INSERM (interface grant), Paris Sud University IDEX 2012, the Fondation de l’Avenir (grant AP-RM-17-013), the Fédération pour la Recherche sur le Cerveau, the National Institutes of Health, Science Foundation Ireland (16/ERCD/3797), USA (Axon, Testosterone and Mental Health during Adolescence, RO1 MH085772-01A1), and by NIH Consortium grant U54 EB020403, supported by a cross-NIH alliance that funds Big Data to Knowledge Centres of Excellence., Project IMAGEN, Human Brain Project, ANR-12-SAMA-0004,ADODEP,Dépression à l'Adolescence: Structure cérébrale et myélinisation(2012), and ANR-18-NEUR-0002,ADORe,TARGETING ADOLESCENT NEUROCOGNITIVE PROCESSES IN DEPRESSION TO PROMOTE INTERVENTION RESPONSE(2018)

Subjects
Longitudinal study, Adolescent, Cognitive Neuroscience, MESH: Cognition, Major depressive disorder, Logistic regression, Adolescents, 050105 experimental psychology, 03 medical and health sciences, 0302 clinical medicine, Cognition, MESH: Risk Factors, Risk Factors, Machine learning, medicine, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Longitudinal Studies, Big Five personality traits, MESH: Longitudinal Studies, Biological Psychiatry, Depression (differential diagnoses), MESH: Adolescent, Depressive Disorder, Major, MESH: Humans, Receiver operating characteristic, business.industry, Depression, 05 social sciences, MESH: Depression / psychology, medicine.disease, Neuroticism, Penalized logistic regression, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Female, Neurology (clinical), MESH: Depressive Disorder, Major* / diagnosis, business, Prediction, MESH: Female, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Clinical psychology
Abstract

BackgroundAdolescent onset of depression is associated with long-lasting negative consequences. Identifying adolescents at risk for developing depression would enable the monitoring of risk factors and the development of early intervention strategies. Using machine learning to combine several risk factors from multiple modalities might allow prediction of depression onset at the individual level. MethodsA subsample of a multisite longitudinal study in adolescents, the IMAGEN study, was used to predict future (subthreshold) major depressive disorder onset in healthy adolescents. Based on 2-year and 5-year follow-up data, participants were grouped into the following: 1) those developing a diagnosis of major depressive disorder or subthreshold major depressive disorder and 2) healthy control subjects. Baseline measurements of 145 variables from different modalities (clinical, cognitive, environmental, and structural magnetic resonance imaging) at age 14 years were used as input to penalized logistic regression (with different levels of penalization) to predict depression onset in a training dataset (n = 407). The features contributing the highest to the prediction were validated in an independent hold-out sample (three independent IMAGEN sites; n = 137). ResultsThe area under the receiver operating characteristic curve for predicting depression onset ranged between 0.70 and 0.72 in the training dataset. Baseline severity of depressive symptoms, female sex, neuroticism, stressful life events, and surface area of the supramarginal gyrus contributed most to the predictive model and predicted onset of depression, with an area under the receiver operating characteristic curve between 0.68 and 0.72 in the independent validation sample. ConclusionsThis study showed that depression onset in adolescents can be predicted based on a combination multimodal data of clinical characteristics, life events, personality traits, and brain structure variables.

Published
2022

5. Violences et rapports de genre. Enquête sur les violences de genre

Author

Brown, Elizabeth, Debauche, Alice, Hamel, Christelle, Mazuy, Magali, Université Paris 1 Panthéon-Sorbonne (UP1), Université de Strasbourg (UNISTRA), Institut national d'études démographiques (INED), Ministère des Droits des femmesMinistère de l’Éducation nationale, de l’enseignement supérieur et de la rechercheMinistère de l’IntérieurInstitut national d’études démographiques (Ined)Mission interministérielle de lutte contre les drogues et les conduites addictives (Mildeca)Institut national de prévention et d’éducation pour la santé (Inpes)Agence nationale de recherche sur le sida et les hépatites virales (ANRS)Centre Hubertine-Auclert – centre francilien de ressources pour l’égalité femmes-hommesCaisse nationale des allocations familiales (Cnaf)Observatoire de l’égalité entre les femmes et les hommes – Ville de ParisAgence nationale pour la cohésion sociale et l’égalité des chances (ACSE)Comité interministériel de prévention de la délinquance et de la radicalisation(CIPDR)Mission de recherche Droit et JusticeDéfenseur des DroitsMutualité françaiseConseil général de l’EssonneConseil général de la SommeConseil général des Bouches-du RhôneConseil général du Val-de-MarneConseil général de Meurthe-et-MoselleConseil général de Seine-Saint-Denis, INED, and Alain Blum et Eva Lelièvre

Subjects
Tentatives de meurtres, [SHS.SOCIO]Humanities and Social Sciences/Sociology, [SHS.STAT]Humanities and Social Sciences/Methods and statistics, Violences intrafamiliales, Violences de genre, Violences sexuelles, Violences conjugales, [SHS.DEMO]Humanities and Social Sciences/Demography, Enquête statistique, Violences contre le minorités, [SHS]Humanities and Social Sciences
Abstract

International audience; Réalisée en 2015 auprès de 27 000 femmes et hommes, l’enquête Violences et rapports de genre (Virage) constitue un outil majeur de mesure et d’analyse des violences subies par les personnes. En interrogeant à la fois les femmes et les hommes, elle rend possible la comparaison des déclarations et l’analyse des effet des normes de genre sur les violences auxquelles femmes et hommes sont confrontés.Quels sont les types de faits, à quelle fréquence et dans quels espaces les violences sont-elles vécues ? Les faits de violence déclarés traduisent-ils les mêmes réalités pour les femmes et les hommes ? Les conséquences matérielles et psychologiques, l’impact sur la santé sont-ils semblables pour les deux sexes ?Complété par des modalités spécifiques (enquêtes par Internet) afin d’atteindre des populations plus difficiles à identifier, le dispositif a permis d’interroger des étudiant·e·s et des personnes LGBT.Les violences fondées sur les rapports de genre sont aujourd’hui au centre d’enjeux sociétaux fortement médiatisés. Leur étude doit enrichir, actualiser et renouveler les connaissances, et fournir des outils solides afin de répondre aux besoins de mise en place et de renforcement des politiques publiques. Elles permettront d’anticiper des situations et des cadres propices à accompagner les personnes qui en sont victimes.

Published
2021

6. Long-term follow-up of children with risk organ-negative Langerhans cell histiocytosis after 2-chlorodeoxyadenosine treatment

Author

Anne Lambilliotte, Nathalie Aladjidi, Jean-François Emile, Geneviève Plat, Sébastien Héritier, Anne Lutun, Mohamed-Aziz Barkaoui, Eric Jeziorski, Caroline Thomas, Fabienne Toutain, J. Donadieu, Despina Moshous, Abdelatif Tazi, Marion Gillibert-Yvert, Kamila Kebaili, Anne Pagnier, Ludovic Mansuy, Damien Bodet, Frédéric Millot, Pascale Schneider, Guy Leverger, Yves Reguerre, Emma Queheille, Hélène Pacquement, Natacha Entz-Werle, Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de référence des Histiocytoses [HU Saint-Louis, Lariboisière, Fernand-Widal - APHP], Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal, Centre de référence des Histiocytoses, Centre Hospitalier Universitaire de Bordeaux (CHU de Bordeaux), Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Département d'Immunologie, hématologie et rhumatologie pédiatriques [Hôpital Necker-Enfants malades - APHP], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University Paris Descartes Sorbonne Paris Cité, Imagine Institute, Paris, Centre Hospitalier Universitaire de Lille (CHU de Lille), Institut d'hématologie et oncologie pédiatriques, 69008 Lyon, France, parent, Service de pédiatrie, adolescents, jeunes adultes [Institut Curie], Institut Curie [Paris], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Hospitalier Régional Universitaire de Strasbourg (CHRU de Strasbourg), Department of Hematology, Centre Hospitalier Universitaire (CHU), Faculté de Médecine, University of Normandie Caen, Centre Hospitalier Universitaire de Rouen, Centre Hospitalo-Universitaire de Grenoble (CHU de Grenoble), CHU Grenoble, CHU Amiens-Picardie, Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre Hospitalier Universitaire de Rennes (CHU Rennes), Centre Hospitalier Universitaire de la Réunion, Saint Denis de la Réunion, Centre hospitalier universitaire de Nantes (CHU Nantes), Immunologie humaine, physiopathologie & immunothérapie (HIPI (UMR_S_976 / U976)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Biomarqueurs et essais cliniques en Cancérologie et Onco-Hématologie (BECCOH), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay, Association Histiocytose France, AHF, Les 111 des Arts Association, la Petite Maison dans la Prairie, Mission Interministérielle de Lutte Contre les Drogues et les Conduites Addictives, MILDECA, Institut de Veille Sanitaire, InVS, Institut National de la Santé et de la Recherche Médicale, Inserm, Roche, Société Française de lutte contre les Cancers de l'Enfant et de l'Adolescent, Fédération Enfants et Santé, the Association Recherche et Maladie Hématologiques de l'Enfant, Gardrat family, Centre de Référence des Histiocytoses, We thank the patients and their families for their participation in this study. The authors thank Dr. Claire Galambrun who contributed to the diagnosis and care of the patient, and Jean Miron for the management of the data. This study was supported by grants from the Soci?t? Fran?aise de lutte contre les Cancers de l'Enfant et de l'Adolescent, the F?d?ration Enfants et Sant?, the Association Recherche et Maladie H?matologiques de l'Enfant, the Association Les 111 des Arts de Paris, and the Association la Petite Maison dans la Prairie. This project received ongoing support from the Association Histiocytose France. The French LCH registry was supported by a grant from InVS and INSERM for the rare disease registry, a grant from Roche, and funds from the Gardrat family. This study was based on research from the Centre de Reference des Histiocytoses (www.histiocytose.org)., and Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)

Subjects
Male, medicine.medical_specialty, Adolescent, [SDV]Life Sciences [q-bio], long-term follow-up, Disease, cladribine, Gastroenterology, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, Langerhans cell histiocytosis, children, Internal medicine, medicine, Chlorodeoxyadenosine, Humans, Cumulative incidence, Lymphocyte Count, Registries, Child, Cladribine, 2-chlorodeoxyadenosine, Childhood Langerhans Cell Histiocytosis, business.industry, Infant, Hematology, medicine.disease, 3. Good health, Discontinuation, Survival Rate, Histiocytosis, Langerhans-Cell, Child, Preschool, 030220 oncology & carcinogenesis, Female, France, business, Progressive disease, Follow-Up Studies, 030215 immunology, medicine.drug
Abstract

International audience; The nucleoside analogue, 2-chlorodeoxyadenosine (2CDA), was reported to be an active treatment for childhood Langerhans cell histiocytosis (LCH) without risk organ (RO−) involvement. However, we lack data on long-term effects of 2CDA treatment, including the disease reactivation rate, permanent sequelae and long-term tolerance. This study included 44 children from the French LCH registry, treated for a RO− LCH with 2CDA monotherapy (median number of six courses). The median age at the beginning of 2CDA was 3·6 years (range, 0·3–19·7 years) and the median follow-up after was 5·4 years (range, 0·6–15·1 years). Objective response to 2CDA was observed in 25 patients (56·8%), while six patients (13·6%) had stable disease and 13 patients (29·5%) exhibited progressive disease. Among patients without progression, only two experienced disease reactivation after 2CDA discontinuation. The five-year cumulative incidence of disease progression or reactivation after 2CDA therapy initiation was 34·3%. The lymphopenia reported in all cases [72% below absolute lymphocyte count (ALC) of 0·5 G/l], was addressed with appropriate prophylactic measures. Other toxicities above grade 2 were uncommon, and no second malignant neoplasm or neuropathy was reported. The five-year overall survival was 97·7%. In conclusion, we could confirm that 2CDA monotherapy was a beneficial long-term therapy for treating patients with RO− LCH. Appropriate management of induced immune deficiency is mandatory.

Published
2020

7. Alcohol, tobacco and cannabis use are associated with job loss at follow-up: Findings from the CONSTANCES cohort

Author

Guillaume Airagnes, Cédric Lemogne, Pierre Meneton, Marie Plessz, Marcel Goldberg, Nicolas Hoertel, Yves Roquelaure, Frédéric Limosin, Marie Zins, Department of Psychiatry and Addictology [Paris], Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Psychiatrie et Neurosciences (U894), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé (LIMICS), Université Paris 13 (UP13)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), The CONSTANCES cohort is supported by the Caisse Nationale d’Assurance Maladie des travailleurs salariés-CNAMTS. CONSTANCES is accredited as a 'National Infrastructure for Biology and health' by the governmental Investissements d’avenir program and was funded by the Agence nationale de la recherche (ANR-11-INBS-0002 Grant). CONSTANCES also receives funding from MSD, AstraZeneca and Lundbeck managed by INSERM-Transfert. This study has received a funding from the Interministerial Mission for Combating Drugs and Addictive Behaviors ('Mission Interministérielle de Lutte contre les Drogues et les Conduites Addictives', MILDECA)., ANR-11-INBS-0002,CONSTANCES,La cohorte CONSTANCES - Infrastructure épidémiologique ouverte pour la recherche et la surveillance(2011), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Bodescot, Myriam, and Infrastructures - La cohorte CONSTANCES - Infrastructure épidémiologique ouverte pour la recherche et la surveillance - - CONSTANCES2011 - ANR-11-INBS-0002 - INBS - VALID

Subjects
Male, Economics, [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Social Sciences, Cohort Studies, Tobacco Use, Habits, Sociology, Medicine and Health Sciences, Smoking Habits, Psychology, Public and Occupational Health, Alcohol Consumption, Depression, Middle Aged, Socioeconomic Aspects of Health, [SDV.TOX] Life Sciences [q-bio]/Toxicology, Behavioral Pharmacology, [SDV.TOX]Life Sciences [q-bio]/Toxicology, Medicine, Female, Marijuana Use, France, Research Article, Adult, Employment, Alcohol Drinking, Science, Jobs, Education, Young Adult, Recreational Drug Use, Mental Health and Psychiatry, Humans, Educational Attainment, Cannabis, Nutrition, Pharmacology, Behavior, Mood Disorders, Biology and Life Sciences, Diet, Health Care, Unemployment, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Labor Economics, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Follow-Up Studies
Abstract

International audience; BACKGROUND:Substance use is more prevalent among unemployed subjects compared to employed ones. However, quantifying the risk subsequent of job loss at short-term according to substance use remains underexplored as well as examining if this association persist across various sociodemographic and occupational positions previously linked to job loss. We examined this issue prospectively for alcohol, tobacco, cannabis use and their combination, among a large population-based sample of men and women, while taking into account age, gender, overall health status and depressive symptoms.METHODS:From the French population-based CONSTANCES cohort, 18,879 working participants were included between 2012 and 2016. At baseline, alcohol use disorder risk according to the Alcohol Use Disorders Identification Test (mild, dangerous, problematic or dependence), tobacco (non-smoker, former smoker, 1-9, 10-19, >19 cigarettes/day) and cannabis use (never, not in past year, less than once a month, once a month or more) were assessed. Employment status at one-year (working versus not working) was the dependent variable. Logistic regressions provided Odds Ratios(OR(95%CI)) of job loss at one-year, adjusting for age, gender, self-reported health and depressive state (measured with the Center of Epidemiologic Studies Depression scale). Stratified analyses were performed for education, occupational grade, household income, job stress (measured with the Effort-Reward Imbalance), type of job contract, type of work time and history of unemployment. In sensitivity analyses, employment status over a three-year follow-up was used as dependent variable.RESULTS:Alcohol, tobacco and cannabis use were associated with job loss, from the second to the highest category: 1.46(95%CI:1.23-1.73) to 1.92(95%CI:1.34-2.75), 1.26(95%CI:1.09-1.46) to 1.78(95%CI:1.26-2.54) and 1.45(95%CI:1.27-1.66) to 2.68(95%CI:2.10-3.42), respectively, and with dose-dependent relationships (all p for trend

Published
2019

8. Thiamine and phosphate esters concentrations in whole blood and serum of patients with alcohol use disorder: a relation with cognitive deficits

Author

François Vabret, Anne-Lise Pitel, Ludivine Ritz, Marie Nowoczyn, Hélène Beaunieux, Coralie Lannuzel, Céline Boudehent, Laurent Coulbault, Beaunieux, Helene, Retour Post-Doctorants - De l'alcoolisme chronique sans complications neurologiques au syndrome de Korsakoff : évaluations clinique, génétique, neuropsychologique et cérébrale - - GO-ALCOBRAIN2010 - ANR-10-PDOC-0006 - RPDOC - VALID, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Laboratoire de psychologie de Caen Normandie (LPCN), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Service d'Addictologie [CHU Caen], Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Neuropsychologie et imagerie de la mémoire humaine (NIMH), Normandie Université (NU)-Normandie Université (NU)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by the French National Institute for Health and Medical Research (INSERM), the French National Agency for Research (ANR) and Postdoc Return (Retour Post-Doctorants, PDOC) program, Lower Normandy Regional Council, and the Mission Interministérielle de Lutte contre les Drogues Et les Conduites Addictives (MILDECA)., ANR-10-PDOC-0006,GO-ALCOBRAIN,De l'alcoolisme chronique sans complications neurologiques au syndrome de Korsakoff : évaluations clinique, génétique, neuropsychologique et cérébrale(2010), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)

Subjects
0301 basic medicine, cognition, vitamin B1, Male, [SDV]Life Sciences [q-bio], Medicine (miscellaneous), Alcohol, Alcohol use disorder, Neuropsychological Tests, chemistry.chemical_compound, [SCCO]Cognitive science, 0302 clinical medicine, Medicine, Thiamine, ComputingMilieux_MISCELLANEOUS, Whole blood, Nutrition and Dietetics, alcohol, General Neuroscience, food and beverages, Montreal Cognitive Assessment, Cognition, montreal cognitive assessment, Esters, General Medicine, Middle Aged, 3. Good health, [SDV] Life Sciences [q-bio], Alcoholism, [SCCO.PSYC] Cognitive science/Psychology, [SCCO.PSYC]Cognitive science/Psychology, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Female, brief evaluation of alcohol-related neuropsychological impairment, Adult, medicine.medical_specialty, alcohol use disorder, Phosphates, 03 medical and health sciences, Internal medicine, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Cognitive Dysfunction, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], 030109 nutrition & dietetics, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience, [SCCO] Cognitive science, medicine.disease, Phosphate, Excessive alcohol consumption, Endocrinology, chemistry, business, human activities, 030217 neurology & neurosurgery
Abstract

Background: In this study, we investigated (1) the effect of chronic and excessive alcohol consumption on whole blood (WB) and serum concentrations of thiamine and its metabolites after supplementa...

Published
2019

9. Prevalence of prescribed benzodiazepine long-term use in the French general population according to sociodemographic and clinical factors: findings from the CONSTANCES cohort

Author

Airagnes, Guillaume, Lemogne, Cedric, Renuy, Adeline, Goldberg, Marcel, Hoertel, Nicolas, Roquelaure, Yves, Limosin, Frédéric, Zins, Marie, Department of Psychiatry and Addictology [Paris], Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Ambulatoire d'Addictologie [Paris], Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre de Psychiatrie et Neurosciences (U894), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Épidémiologie en Santé au Travail et Ergonomie (IRSET-ESTER), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CONSTANCES is accredited as a 'National Infrastructure for Biology and health' by the governmental Investissements d’avenir program and was funded by the Agence nationale de la recherche (ANR-11-INBS-0002 Grant). CONSTANCES also receives funding from MSD, AstraZeneca and Lundbeck managed by INSERM-Transfert. This study has received a funding from the Interministerial Mission for Combating Drugs and Addictive Behaviors ('Mission Interministérielle de Lutte contre les Drogues et les Conduites Addictives', MILDECA)., ANR-11-INBS-0002,CONSTANCES,La cohorte CONSTANCES - Infrastructure épidémiologique ouverte pour la recherche et la surveillance(2011), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Bodescot, Myriam, and Infrastructures - La cohorte CONSTANCES - Infrastructure épidémiologique ouverte pour la recherche et la surveillance - - CONSTANCES2011 - ANR-11-INBS-0002 - INBS - VALID

Subjects
Adult, Employment, Male, Long-term use, Time Factors, Misuse, [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Administrative registries, Drug Prescriptions, Cohort Studies, Benzodiazepines, Odds Ratio, Prevalence, Humans, Registries, Aged, Benzodiazepine, Marital Status, Depression, lcsh:Public aspects of medicine, lcsh:RA1-1270, General population, Sociodemographic factors, Middle Aged, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, French national cohort, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Insurance, Health, Reimbursement, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Alcohol use, Research Article
Abstract

Background Data are lacking regarding the prevalence of benzodiazepine long-term use in the general population. Our aim was to examine the prevalence of prescribed benzodiazepine long-term use (BLTU) according to sociodemographic and clinical factors in the French general population. Methods Data came from 4686 men and 4849 women included in 2015 in the French population-based CONSTANCES cohort. BLTU was examined using drug reimbursement administrative registries from 2009 to 2015. Analyses were weighted to provide results representative of the French general population covered by the general health insurance scheme. Weighted prevalence of BTLU and weighted Odds Ratios (OR) of having BTLU were computed with their 95% Confidence Interval (95% CI) according to age, education level, occupational status, occupational grade, household income, marital status, alcohol use disorder risk and depressive symptoms. All the analyses were stratified for gender. Results Weighted prevalence of BLTU were 2.8%(95% CI:2.3–3.4) and 3.8%(95% CI: 3.3–4.5) in men and women, respectively. Compared to men, women had an increased risk of having benzodiazepine long-term use with OR = 1.34(95% CI = 1.02–1.76). Aging, low education, not being at-work, low occupational grade, low income, being alone and depressive state were associated with increased risks of having BTLU. Conclusions BLTU is widespread in the French general population, however this issue may particularly concern vulnerable subgroups. These findings may help in raising attention on this public health burden as well as targeting specific at-risk subgroups in preventive intervention. Electronic supplementary material The online version of this article (10.1186/s12889-019-6933-8) contains supplementary material, which is available to authorized users.

Published
2019

10. Adolescent binge drinking disrupts normal trajectories of brain functional organization and personality maturation

Author

Zhaowen Liu, Herta Flor, Frauke Nees, Gabriel Robert, Christian Büchel, Juliane H. Fröhner, Tobias Banaschewski, Yunyi Zhou, Michael N. Smolka, Sylvane Desrivières, Fei Li, Qiang Luo, Robert Whelan, Andreas Heinz, Arun L.W. Bokde, Gunter Schumann, Luise Poustka, Erin Burke Quinlan, Marie-Laure Paillère Martinot, Henrik Walter, Penny A. Gowland, Vincent Frouin, Jianfeng Feng, Hongtao Ruan, Bernd Ittermann, Hugh Garavan, Jean-Luc Martinot, Dimitri Papadopoulos Orfanos, Uli Bromberg, Sarah Hohmann, Jonchère, Laurent, Santé Mentale et Addictions - Dépression à l'Adolescence: Structure cérébrale et myélinisation - - ADODEP2012 - ANR-12-SAMA-0004 - SAMENTA - VALID, Fudan University [Shanghai], Comportement et noyaux gris centraux = Behavior and Basal Ganglia [Rennes], Université de Rennes (UR)-Université européenne de Bretagne - European University of Brittany (UEB)-CHU Pontchaillou [Rennes]-Institut des Neurosciences Cliniques de Rennes (INCR), Institute of Psychiatry, Psychology & Neuroscience, King's College London, King‘s College London, Xidian University, Central Institute of Mental Health [Mannheim], Medical Faculty [Mannheim], Discipline of Psychiatry [Dublin], School of Medicine [Dublin], Trinity College Dublin-Trinity College Dublin, Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), University of Vermont [Burlington], University of Nottingham, UK (UON), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Physikalisch-Technische Bundesanstalt [Braunschweig] (PTB), Neuroimagerie en psychiatrie (U1000), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Heidelberg University, University Medical Center Göttingen (UMG), Technische Universität Dresden = Dresden University of Technology (TU Dresden), MR/N000390/1, Medical Research Council Canada, 20152234, Shanghai Municipal Education Commission, AERIAL 01EE1406A, Bundesministeriumfür Bildung und Forschung, ANR-12-SAMA-0004, ANR, Shanghai AI Platform for Diagnosis and Treatment of Brain Diseases, Fondation pour la Recherche Médicale, Assistance-Publique-Hôpitaux-de-Paris, 16/ERCD/3797, National Institutes of Health, Science Foundation Ireland, IDEX 2012, Université Paris-Sud, RO1 MH085772-01A1, U.S.A., U54 EB020403, NIH, National Institute for Health Research, MR/N027558/1, BRIDGET, 81761128035, National Natural Science Foundation of China, Fondation de France, LSHM-CT- 2007-037286, European Commission, 2016-17, Project of Zhangjiang Hi-Tech District Management Committee, Shanghai, SFB 940/1, Deutsche Forschungsgemeinschaft, 695313, Horizon 2020 Framework Programme, Mission Interministérielle de Lutte Contre les Drogues et les Conduites Addictives, 17ZR1444400, Natural Science Foundation of Shanghai, Svenska Forskningsrådet Formas, 2018SHZDZX01, Shanghai Municipal Science and Technology, 602450, FP7, Zhangjiang Lab, 16JC1420402, Shanghai Science and Technology Innovation Plan, B18015, Higher Education Discipline Innovation Project, GDEK201709, Shanghai Municipal Commission of Health and Family Planning, 16CR2025B, Shanghai Shenkang Hospital Development Center, 17XD1403200, Shanghai Committee of Science and Technology, 2018YJRC03, Xinhua Hospital of Shanghai Jiao Tong University School of Medicine, PR-ST-0416-10004, ERANID, Institut National de la Santé et de la Recherche Médicale, 603016, MATRICS, 115300-2, Innovative Medicine Initiative Project EU-AIMS, Maudsley NHS Foundation Trust, 2018YFC0910503, National Basic Research Program of China (973 Program), King's College London, ANR-12-SAMA-0004,ADODEP,Dépression à l'Adolescence: Structure cérébrale et myélinisation(2012), Université de Rennes (UR)-Université européenne de Bretagne - European University of Brittany (UEB)-CHU Pontchaillou [Rennes]-Institut des Neurosciences Cliniques de Rennes = Institute of Clinical Neurosciences of Rennes (INCR), University Hospital Mannheim | Universitätsmedizin Mannheim, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université européenne de Bretagne - European University of Brittany (UEB)-CHU Pontchaillou [Rennes]-Institut des Neurosciences Cliniques de Rennes (INCR), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Sud - Paris 11 (UP11)

Subjects
Male, Support Vector Machine, Time Factors, Co-development, [SDV]Life Sciences [q-bio], iFC, increased rsFC, Binge drinking, Underage Drinking, Adolescent, Genome, Personality, Resting state, lcsh:RC346-429, 0302 clinical medicine, rsFC, resting-state functional connectivity, Longitudinal Studies, Cantab, Cambridge Neuropsychological Test Automated Battery, Age of Onset, Big Five personality traits, media_common, rsfMRI, resting-state fMRI, ANOVA, Analysis of Variance, NEO-PI-R, Revised NEO Personality Inventory, 05 social sciences, Brain, Regular Article, SNP, single nucleotide polymorphism, Magnetic Resonance Imaging, [SDV] Life Sciences [q-bio], ESPAD, European School Survey Project on Alcohol and Drugs, Neurology, lcsh:R858-859.7, Female, Functional organization, medicine.symptom, Psychology, Alcohol consumption, Clinical psychology, Adult, FDR, false discovery rate, Cognitive Neuroscience, media_common.quotation_subject, SVM, support-vector machine, AUC, area under curve, Impulsivity, lcsh:Computer applications to medicine. Medical informatics, 050105 experimental psychology, Young Adult, 03 medical and health sciences, Connectome, medicine, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, pSNP, protective SNP, ROC, receiver operational characteristic, lcsh:Neurology. Diseases of the nervous system, rSNP, risk SNP, dFC, decreased rsFC, Resting state fMRI, Adolescent Development, Mental health, LOO, leave-one-out, NRI, net reclassification improvement, Personality Development, Impulsive Behavior, Neurology (clinical), SURPS, Substance Use Risk Profile Scale, 030217 neurology & neurosurgery
Abstract

Adolescent binge drinking has been associated with higher risks for the development of many health problems throughout the lifespan. Adolescents undergo multiple changes that involve the co-development processes of brain, personality and behavior; therefore, certain behavior, such as alcohol consumption, can have disruptive effects on both brain development and personality maturation. However, these effects remain unclear due to the scarcity of longitudinal studies. In the current study, we used multivariate approaches to explore discriminative features in brain functional architecture, personality traits, and genetic variants in 19-year-old individuals (n = 212). Taking advantage of a longitudinal design, we selected features that were more drastically altered in drinkers with an earlier onset of binge drinking. With the selected features, we trained a hierarchical model of support vector machines using a training sample (n = 139). Using an independent sample (n = 73), we tested the model and achieved a classification accuracy of 71.2%. We demonstrated longitudinally that after the onset of binge drinking the developmental trajectory of improvement in impulsivity slowed down. This study identified the disrupting effects of adolescent binge drinking on the developmental trajectories of both brain and personality., Highlights • History of binge drinking could be identified by multivariate features at age 19. • Adolescent binge drinking disrupted frontal connectivity maturation in the brain. • Impulsivity improvement slowed down after the onset of adolescent binge drinking.

Published
2019

11. Pratiques d'usage-revente de drogues dans six groupes de jeunes : analyse d'un phénomène ignoré et stratégies pour la prévention (PURDROG)

Author

Emmanuel Langlois, Centre Émile Durkheim (CED), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-Sciences Po Bordeaux - Institut d'études politiques de Bordeaux (IEP Bordeaux), Mission interministérielle de lutte contre les drogues et les conduites addictives (MILDECA), Institut National du Cancer (INCa), Prévention, Drogues & Société (PREVDROG), and Sciences Po Bordeaux - Institut d'études politiques de Bordeaux (IEP Bordeaux)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)

Subjects
usage-ventes, drogues, [SHS.SOCIO]Humanities and Social Sciences/Sociology, jeunes, Addictions, lutte contre les drogues, [SHS.SCIPO]Humanities and Social Sciences/Political science
Abstract

Ce dispositif incitatif axé sur les problématiques de drogues et de conduites addictives vise à susciter des recherches appliquées en sciences humaines et sociales et en recherche clinique, porteuses de recommandations utiles à l’élaboration des politiques publiques de prévention.

Published
2016

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