30 results on '"Molinos, C."'
Search Results
2. Individual neutron monitoring in workplaces with mixed neutron/photon radiation
- Author
-
Bolognese-Milsztajn, T., Bartlett, D., Boschung, M., Coeck, M., Curzio, G., d'Errico, F., Fiechtner, A., Giusti, V., Gressier, V., Kyllönen, J., Lacoste, V., Lindborg, L., Luszik-Bhadra, M., Molinos, C., Pelcot, G., Reginatto, M., Schuhmacher, H., Tanner, R., Vanhavere, F., Derdau, D., Bolognese-Milsztajn, T., Bartlett, D., Boschung, M., Coeck, M., Curzio, G., d'Errico, F., Fiechtner, A., Giusti, V., Gressier, V., Kyllönen, J., Lacoste, V., Lindborg, L., Luszik-Bhadra, M., Molinos, C., Pelcot, G., Reginatto, M., Schuhmacher, H., Tanner, R., Vanhavere, F., and Derdau, D. more...
- Abstract
EVIDOS (‘evaluation of individual dosimetry in mixed neutron and photon radiation fields') is an European Commission (EC)-sponsored project that aims at a significant improvement of radiation protection dosimetry in mixed neutron/photon fields via spectrometric and dosimetric investigations in representative workplaces of the nuclear industry. In particular, new spectrometry methods are developed that provide the energy and direction distribution of the neutron fluence from which the reference dosimetric quantities are derived and compared to the readings of dosemeters. The final results of the project will be a comprehensive set of spectrometric and dosimetric data for the workplaces and an analysis of the performance of dosemeters, including novel electronic dosemeters. This paper gives an overview of the project and focuses on the results from measurements performed in calibration fields with broad energy distributions (simulated workplace fields) and on the first results from workplaces in the nuclear industry, inside a boiling water reactor and around a spent fuel transport cask more...
- Published
- 2017
Catalog
3. Electronic neutron personal dosemeters: their performance in mixed radiation fields in nuclear power plants
- Author
-
Luszik-Bhadra, M., Bartlett, D., Boschung, M., Coeck, M., Curzio, G., Derdau, D., d'Errico, F., Fiechtner, A., Itié, C., Kyllönen, J.-E, Lacoste, V., Lahaye, T., Lindborg, L., Molinos, C., Reginatto, M., Schuhmacher, H., Tanner, R., Vanhavere, F., Luszik-Bhadra, M., Bartlett, D., Boschung, M., Coeck, M., Curzio, G., Derdau, D., d'Errico, F., Fiechtner, A., Itié, C., Kyllönen, J.-E, Lacoste, V., Lahaye, T., Lindborg, L., Molinos, C., Reginatto, M., Schuhmacher, H., Tanner, R., and Vanhavere, F. more...
- Abstract
This work describes spectral distributions of neutrons obtained as function of energy and direction at four workplace fields at the Krümmel reactor in Germany. Values of personal dose equivalent Hp(10) and effective dose E are determined for different directions of a person's orientation in these fields and readings of personal neutron dosemeters—especially electronic dosemeters—are discussed with respect to Hp(10) and E more...
- Published
- 2017
4. Evaluation of individual monitoring in mixed neutron/photon fields: mid-term results from the EVIDOS project
- Author
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Vanhavere, F., Bartlett, D., Bolognese-Milsztajn, T., Boschung, M., Coeck, M., Curzio, G., d'Errico, F., Fiechtner, A., Kyllönen, J., Lacoste, V., Lahaye, T., Lindborg, L., Luszik-Bhadra, M., Molinos, C., Muller, H., Reginatto, M., Schuhmacher, H., Tanner, R., Vanhavere, F., Bartlett, D., Bolognese-Milsztajn, T., Boschung, M., Coeck, M., Curzio, G., d'Errico, F., Fiechtner, A., Kyllönen, J., Lacoste, V., Lahaye, T., Lindborg, L., Luszik-Bhadra, M., Molinos, C., Muller, H., Reginatto, M., Schuhmacher, H., and Tanner, R. more...
- Abstract
EVIDOS is an EC sponsored project that aims at an evaluation and improvement of radiation protection dosimetry in mixed neutron/photon fields. This is performed through spectrometric and dosimetric investigations during different measurement campaigns in representative workplaces of the nuclear industry. The performance of routine and, in particular, novel personal dosemeters and survey instruments is tested in selected workplace fields. Reference values for the dose equivalent quantities, H*(10) and Hp(10) and the effective dose E, are determined using different spectrometers that provide the energy distribution of the neutron fluence and using newly developed devices that determine the energy and directional distribution of the neutron fluence. The EVIDOS project has passed the mid-term, and three measurement campaigns have been performed. This paper will give an overview and some new results from the third campaign that was held in Mol (Belgium), around the research reactor VENUS and in the MOX producing plant of Belgonucléaire more...
- Published
- 2017
5. Neutron area survey instrument measurements in the EVIDOS project
- Author
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Tanner, R. J., Bolognese-Milsztajn, T., Boschung, M., Coeck, M., Curzio, G., d'Errico, F., Fiechtner, A., Hager, L. G., Hussien, M., Kyllönen, J.-E, Lacoste, V., Lindborg, L., Luszik-Bhadra, M., Molinos, C., Reginatto, M., Schuhmacher, H., Vanhavere, F., Tanner, R. J., Bolognese-Milsztajn, T., Boschung, M., Coeck, M., Curzio, G., d'Errico, F., Fiechtner, A., Hager, L. G., Hussien, M., Kyllönen, J.-E, Lacoste, V., Lindborg, L., Luszik-Bhadra, M., Molinos, C., Reginatto, M., Schuhmacher, H., and Vanhavere, F. more...
- Abstract
Neutron survey instruments have been exposed at all the measurement locations used in the EVIDOS project. These results have an important impact in the interpretation of the results from the project, since operationally the survey instrument will be used for an initial assessment of and routine monitoring of the ambient dose equivalent dose rate. Additionally, since the response of these instruments is in some cases very well characterised, their systematic deviations from the reference quantities provide an important verification of the determination of those quantities more...
- Published
- 2017
6. Individual monitoring in workplaces with mixed neutron/photon radiation
- Author
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BOLOGNESE MILSZTAJN, T, Bartlett, B, Boschung, M, Coeck, M, Curzio, Giorgio, D'Errico, Francesco, Fiechtner, A, Giusti, Valerio, Gressier, V, Lacoste, V, Lindborg, L, LUSZIK BHADRA, M, Molinos, C, Pelcot, G, Reginatto, M, Schuhmacher, H, Tanner, R, Vanhavere, V, and Derdau, D. more...
- Published
- 2004
7. Pathological complete remission with preoperative hyperfractionated chemoradiation v/s standard chemoradiation
- Author
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Villamil Montufar, S., primary, Pena Vivas, J., additional, García Morales, M., additional, Fuentes Sánchez, C., additional, Hernández González, R., additional, Martínez Cedres, J., additional, Armijo Mallorquin, A., additional, Martín Ortega, J., additional, Espineira Yanes, M., additional, and Borque Molinos, C., additional more...
- Published
- 2013
- Full Text
- View/download PDF
8. Neutron area survey instrument measurements in the EVIDOS project
- Author
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Tanner, R. J., primary, Bolognese-Milsztajn, T., additional, Boschung, M., additional, Coeck, M., additional, Curzio, G., additional, d'Errico, F., additional, Fiechtner, A., additional, Hager, L. G., additional, Hussien, M., additional, Kyllonen, J.-E., additional, Lacoste, V., additional, Lindborg, L., additional, Luszik-Bhadra, M., additional, Molinos, C., additional, Reginatto, M., additional, Schuhmacher, H., additional, and Vanhavere, F., additional more...
- Published
- 2006
- Full Text
- View/download PDF
9. Evaluation of individual monitoring in mixed neutron/photon fields: mid-term results from the EVIDOS project
- Author
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Vanhavere, F., primary, Bartlett, D., additional, Bolognese-Milsztajn, T., additional, Boschung, M., additional, Coeck, M., additional, Curzio, G., additional, d'Errico, F., additional, Fiechtner, A., additional, Kyllönen, J., additional, Lacoste, V., additional, Lahaye, T., additional, Lindborg, L., additional, Luszik-Bhadra, M., additional, Molinos, C., additional, Muller, H., additional, Reginatto, M., additional, Schuhmacher, H., additional, and Tanner, R., additional more...
- Published
- 2006
- Full Text
- View/download PDF
10. Electronic neutron personal dosemeters: their performance in mixed radiation fields in nuclear power plants
- Author
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Luszik-Bhadra, M., primary, Bartlett, D., additional, Boschung, M., additional, Coeck, M., additional, Curzio, G., additional, Derdau, D., additional, d'Errico, F., additional, Fiechtner, A., additional, Itié, C., additional, Kyllönen, J.-E., additional, Lacoste, V., additional, Lahaye, T., additional, Lindborg, L., additional, Molinos, C., additional, Reginatto, M., additional, Schuhmacher, H., additional, Tanner, R., additional, and Vanhavere, F., additional more...
- Published
- 2006
- Full Text
- View/download PDF
11. Modelling of neutron survey instrument performance and experimental validation of those calculated response data
- Author
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Tanner, R. J., primary, Bartlett, D. T., additional, Hager, L. G., additional, Jones, L. N., additional, Molinos, C., additional, Roberts, N. J., additional, Taylor, G. C., additional, and Thomas, D. J., additional more...
- Published
- 2005
- Full Text
- View/download PDF
12. Individual neutron monitoring in workplaces with mixed neutron/photon radiation
- Author
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Bolognese-Milsztajn, T., primary, Bartlett, D., additional, Boschung, M., additional, Coeck, M., additional, Curzio, G., additional, d'Errico, F., additional, Fiechtner, A., additional, Giusti, V., additional, Gressier, V., additional, Kyllonen, J., additional, Lacoste, V., additional, Lindborg, L., additional, Luszik-Bhadra, M., additional, Molinos, C., additional, Pelcot, G., additional, Reginatto, M., additional, Schuhmacher, H., additional, Tanner, R., additional, Vanhavere, F., additional, and Derdau, D., additional more...
- Published
- 2004
- Full Text
- View/download PDF
13. Angle dependence of response characteristics of neutron survey instruments
- Author
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Roberts, N. J., primary, Bartlett, D. T., additional, Hager, L. G., additional, Jones, L. N., additional, Molinos, C., additional, Tanner, R. J., additional, Taylor, G. C., additional, and Thomas, D. J., additional more...
- Published
- 2004
- Full Text
- View/download PDF
14. Practical implications of neutron survey instrument performance
- Author
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Tanner, R. J., primary, Bartlett, D. T., additional, Hager, L. G., additional, Jones, L. N., additional, Molinos, C., additional, Roberts, N. J., additional, Taylor, G. C., additional, and Thomas, D. J., additional more...
- Published
- 2004
- Full Text
- View/download PDF
15. NEUTRON AREA SURVEY INSTRUMENT MEASUREMENTS IN THE EVIDOS PROJECT.
- Author
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Tanner, R. J., Bolognese-Milsztajn, T., Boschung, M., Coeck, M., Curzio, G., d'Errico, F., Fiechtner, A., Hager, L. G., Hussien, M., Kyllönen, J.-E., Lacoste, V., Lindborg, L., Luszik-Bhadra, M., Molinos, C., Reginatto, M., Schuhmacher, H., and Vanhavere, F. more...
- Subjects
NEUTRONS ,DOSE-response relationship in ionizing radiation ,EVALUATION ,NUCLEAR research ,RADIATION measurement instruments ,PARTICLES (Nuclear physics) - Abstract
Neutron survey instruments have been exposed at all the measurement locations used in the EVIDOS project. These results have an important impact in the interpretation of the results from the project, since operationally the survey instrument will be used for an initial assessment of and routine monitoring of the ambient dose equivalent dose rate. Additionally, since the response of these instruments is in some cases very well characterised, their systematic deviations from the reference quantities provide an important verification of the determination of those quantities. [ABSTRACT FROM AUTHOR] more...
- Published
- 2007
- Full Text
- View/download PDF
16. ELECTRONIC NEUTRON PERSONAL DOSEMETERS: THEIR PERFORMANCE IN MIXED RADIATION FIELDS IN NUCLEAR POWER PLANTS.
- Author
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M. Luszik-Bhadrai, Bartlett, D., Boschung, M., Coeck, M., Curzio, G., Derdau, D., d'Errico, F., Fiechtner, A., Itié, C., J.-E. Kyllönen, Lacoste, V., Lahaye, L., Lindborg, L., Molinos, C., Reginatto, M., Schuhmacher, H., Tanner, R., and Vanhavere, F. more...
- Subjects
NUCLEAR power plants ,NEUTRONS ,PARTICLES (Nuclear physics) ,NUCLEAR energy ,THERMOLUMINESCENCE dosimetry ,NUCLEAR reactors ,NUCLEAR facilities ,NUCLEAR physics ,ELECTRIC power plants - Abstract
This work describes spectral distributions of neutrons obtained as function of energy and direction at four workplace fields at the Krümmel reactor in Germany. Values of personal dose equivalent H
ubscript>p(10) and effective dose E are determined for different directions of a person's orientation in these fields and readings of personal neutron dosemeters—especially electronic dosemeters—are discussed with respect to Hp (10) and E. [ABSTRACT FROM AUTHOR] more...- Published
- 2006
- Full Text
- View/download PDF
17. Electronic neutron personal dosemeters: their performance in mixed radiation fields in nuclear power plants
- Author
-
Luszik-Bhadra, M., Bartlett, D., Boschung, M., Coeck, M., Curzio, G., Derdau, D., d'Errico, F., Fiechtner, A., Itié, C., Kyllönen, J.-E, Lacoste, V., Lahaye, T., Lindborg, L., Molinos, C., Reginatto, M., Schuhmacher, H., Tanner, R., Vanhavere, F., Luszik-Bhadra, M., Bartlett, D., Boschung, M., Coeck, M., Curzio, G., Derdau, D., d'Errico, F., Fiechtner, A., Itié, C., Kyllönen, J.-E, Lacoste, V., Lahaye, T., Lindborg, L., Molinos, C., Reginatto, M., Schuhmacher, H., Tanner, R., and Vanhavere, F. more...
- Abstract
This work describes spectral distributions of neutrons obtained as function of energy and direction at four workplace fields at the Krümmel reactor in Germany. Values of personal dose equivalent Hp(10) and effective dose E are determined for different directions of a person's orientation in these fields and readings of personal neutron dosemeters—especially electronic dosemeters—are discussed with respect to Hp(10) and E more...
18. Individual neutron monitoring in workplaces with mixed neutron/photon radiation
- Author
-
Bolognese-Milsztajn, T., Bartlett, D., Boschung, M., Coeck, M., Curzio, G., d'Errico, F., Fiechtner, A., Giusti, V., Gressier, V., Kyllönen, J., Lacoste, V., Lindborg, L., Luszik-Bhadra, M., Molinos, C., Pelcot, G., Reginatto, M., Schuhmacher, H., Tanner, R., Vanhavere, F., Derdau, D., Bolognese-Milsztajn, T., Bartlett, D., Boschung, M., Coeck, M., Curzio, G., d'Errico, F., Fiechtner, A., Giusti, V., Gressier, V., Kyllönen, J., Lacoste, V., Lindborg, L., Luszik-Bhadra, M., Molinos, C., Pelcot, G., Reginatto, M., Schuhmacher, H., Tanner, R., Vanhavere, F., and Derdau, D. more...
- Abstract
EVIDOS (‘evaluation of individual dosimetry in mixed neutron and photon radiation fields') is an European Commission (EC)-sponsored project that aims at a significant improvement of radiation protection dosimetry in mixed neutron/photon fields via spectrometric and dosimetric investigations in representative workplaces of the nuclear industry. In particular, new spectrometry methods are developed that provide the energy and direction distribution of the neutron fluence from which the reference dosimetric quantities are derived and compared to the readings of dosemeters. The final results of the project will be a comprehensive set of spectrometric and dosimetric data for the workplaces and an analysis of the performance of dosemeters, including novel electronic dosemeters. This paper gives an overview of the project and focuses on the results from measurements performed in calibration fields with broad energy distributions (simulated workplace fields) and on the first results from workplaces in the nuclear industry, inside a boiling water reactor and around a spent fuel transport cask more...
19. Neutron area survey instrument measurements in the EVIDOS project
- Author
-
Tanner, R. J., Bolognese-Milsztajn, T., Boschung, M., Coeck, M., Curzio, G., d'Errico, F., Fiechtner, A., Hager, L. G., Hussien, M., Kyllönen, J.-E, Lacoste, V., Lindborg, L., Luszik-Bhadra, M., Molinos, C., Reginatto, M., Schuhmacher, H., Vanhavere, F., Tanner, R. J., Bolognese-Milsztajn, T., Boschung, M., Coeck, M., Curzio, G., d'Errico, F., Fiechtner, A., Hager, L. G., Hussien, M., Kyllönen, J.-E, Lacoste, V., Lindborg, L., Luszik-Bhadra, M., Molinos, C., Reginatto, M., Schuhmacher, H., and Vanhavere, F. more...
- Abstract
Neutron survey instruments have been exposed at all the measurement locations used in the EVIDOS project. These results have an important impact in the interpretation of the results from the project, since operationally the survey instrument will be used for an initial assessment of and routine monitoring of the ambient dose equivalent dose rate. Additionally, since the response of these instruments is in some cases very well characterised, their systematic deviations from the reference quantities provide an important verification of the determination of those quantities more...
20. Evaluation of individual monitoring in mixed neutron/photon fields: mid-term results from the EVIDOS project
- Author
-
Vanhavere, F., Bartlett, D., Bolognese-Milsztajn, T., Boschung, M., Coeck, M., Curzio, G., d'Errico, F., Fiechtner, A., Kyllönen, J., Lacoste, V., Lahaye, T., Lindborg, L., Luszik-Bhadra, M., Molinos, C., Muller, H., Reginatto, M., Schuhmacher, H., Tanner, R., Vanhavere, F., Bartlett, D., Bolognese-Milsztajn, T., Boschung, M., Coeck, M., Curzio, G., d'Errico, F., Fiechtner, A., Kyllönen, J., Lacoste, V., Lahaye, T., Lindborg, L., Luszik-Bhadra, M., Molinos, C., Muller, H., Reginatto, M., Schuhmacher, H., and Tanner, R. more...
- Abstract
EVIDOS is an EC sponsored project that aims at an evaluation and improvement of radiation protection dosimetry in mixed neutron/photon fields. This is performed through spectrometric and dosimetric investigations during different measurement campaigns in representative workplaces of the nuclear industry. The performance of routine and, in particular, novel personal dosemeters and survey instruments is tested in selected workplace fields. Reference values for the dose equivalent quantities, H*(10) and Hp(10) and the effective dose E, are determined using different spectrometers that provide the energy distribution of the neutron fluence and using newly developed devices that determine the energy and directional distribution of the neutron fluence. The EVIDOS project has passed the mid-term, and three measurement campaigns have been performed. This paper will give an overview and some new results from the third campaign that was held in Mol (Belgium), around the research reactor VENUS and in the MOX producing plant of Belgonucléaire more...
21. PET/MR – simultaneous hybrid imaging with Intragate: freezing PET cardiac and respiratory motion with MRI
- Author
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Nauerth, A, Eigner, S, Himmelreich, U, Molinos, C, Correcher, C, Heidenreich, M, Oerther, C, Deroose, CM, and Gsell, W
- Published
- 2019
- Full Text
- View/download PDF
22. Qualche riflessione a proposito delle guerre puniche
- Author
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BRIZZI, GIOVANNI, J.P. Bellón Ruiz, A. Ruiz Rodríguez, M. Molinos Molinos, C. Rueda Galán y F. Gómez Cabeza, and Brizzi, Giovanni
- Subjects
Baecula ,Cartagine, Amilcare Barca ,Guerre puniche ,Annibale - Abstract
Contributo introduttivo contenente le linee generali in occasione del grande convegno relativo alla scoperta del campo di Baecula.
- Published
- 2015
23. The intestinal microbiome of infants with cow's milk-induced FPIES is enriched in taxa and genes of enterobacteria.
- Author
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Castro AM, Sabater C, Gutiérrez-Díaz I, Navarro S, Rodriguez S, Molinos C, Jiménez S, Claver A, Espin B, Domínguez G, Coronel C, Toyos P, Sariego L, Fernández P, Perez D, Margolles A, Díaz JJ, and Delgado S more...
- Subjects
- Humans, Infant, Male, Female, Animals, Case-Control Studies, Fatty Acids metabolism, Milk microbiology, Dysbiosis microbiology, Gastrointestinal Microbiome, Milk Hypersensitivity microbiology, Milk Hypersensitivity immunology, Feces microbiology, Enterobacteriaceae isolation & purification, Enterocolitis microbiology
- Abstract
Objectives: Food protein-induced enterocolitis syndrome (FPIES) is a severe type of non-IgE (immunoglobulin E)-mediated (NIM) food allergy, with cow's milk (CM) being the most common offending food. The relationship between the gut microbiota and its metabolites with the inflammatory process in infants with CM FPIES is unknown, although evidence suggests a microbial dysbiosis in NIM patients. This study was performed to contribute to the knowledge of the interaction between the gut microbiota and its derived metabolites with the local immune system in feces of infants with CM FPIES at diagnosis., Methods: Twelve infants with CM FPIES and a matched healthy control group were recruited and the gut microbiota was investigated by 16S amplicon and shotgun sequencing. Fatty acids (FAs) were measured by gas chromatography, while immune factors were determined by enzyme-linked immunosorbent assay and Luminex technology., Results: A specific pattern of microbiota in the gut of CM FPIES patients was found, characterized by a high abundance of enterobacteria. Also, an intense excretion of FAs in the feces of these infants was observed. Furthermore, correlations were found between fecal bifidobacteria and immune factors., Conclusion: These fecal determinations may be useful to gain insight into the pathophysiology of this syndrome and should be taken in consideration for future studies of FPIES patients., (© 2024 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.) more...
- Published
- 2024
- Full Text
- View/download PDF
24. Evolutive Study of Dietary Aspects and Intestinal Microbiota of Pediatric Cohort with Cow's Milk Protein Allergy.
- Author
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Castro AM, Navarro S, Carvajal I, García A, Suárez M, Toyos P, Rodríguez S, Jimenez S, González D, Molinos C, Pérez-Solís D, Fernández P, Margolles A, Díaz-Martín JJ, Gutiérrez-Díaz I, and Delgado S
- Abstract
Background: One of the most common food allergies in the pediatric population is allergy to cow's milk protein (CMPA). Treatment consists of avoiding cow's milk proteins in lactating mothers and/or using therapeutic formulas based on hydrolysates or vegetable formulas. In infants with CMPA at diagnosis, a different gut microbial profile has been found compared to healthy children, with a reduction in beneficial bacteria. The aim of this study was to evaluate changes in the gut microbiota profile and its metabolites, dietary patterns and anthropometric variables in a pediatric cohort with CMPA after six months on a restrictive diet compared to healthy controls., Methods: In total, 21 patients diagnosed with CMPA and a control group of 24 healthy infants participated in this study. The fecal microbiota of all participants were investigated by metataxonomic analysis of 16S rDNA amplicons, and fecal short-chain fatty acids were measured by gas chromatography. Epidemiological assessment and dietary questionnaires were carried out for both groups., Results: Regarding growth, no significant differences were found, but differences in dietary intake of some macro- and micronutrients were observed. Patients who were breastfed at six months had higher bifidobacteria and lipid intakes than patients fed with hydrolyzed formulas., Conclusions: Although the growth of CMPA infants fed with therapeutic formula is similar to breastfed CMPA infants, there are differences in microbiota composition and macronutrient intake that underline the importance of continued breastfeeding in CMPA cases. more...
- Published
- 2024
- Full Text
- View/download PDF
25. Gut microbiota and inflammatory mediators differentiate IgE mediated and non-IgE mediated cases of cow's milk protein at diagnosis.
- Author
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Castro AM, Gutiérrez-Díaz I, Saiz ML, Navarro S, Suárez M, Carbajal I, García Á, Sariego L, Toyos P, Rodríguez S, Jiménez S, González D, Molinos C, Pérez D, Fernández P, Suárez-Alvarez B, Margolles A, Díaz JJ, and Delgado S more...
- Subjects
- Infant, Female, Animals, Humans, Cattle, Immunoglobulin E, Milk Proteins, Gastrointestinal Microbiome, Milk Hypersensitivity diagnosis, Food Hypersensitivity
- Abstract
Objective: Analyze fecal and blood samples at point of diagnosis in IgE mediated cow's milk protein allergy (CMPA) and non-IgE mediated (NIM)-CMPA patients to look for potential new biomarkers., Patients and Methods: Fourteen patients with IgE mediated CMPA and 13 with NIM-CMPA were recruited in three hospitals in the north of Spain, and were compared with 25 infants from a control group of the same age range. To characterize intestinal microbiota, 16S rDNA gene and internal transcribed spacer amplicons of bifidobacteria were sequenced with Illumina technology. Fatty acids were analyzed by gas chromatography, meanwhile intestinal inflammation markers were quantified by enzyme-linked immunosorbent assay and a multiplex system. Immunological analysis of blood was performed by flow cytometry., Results: The fecal results obtained in the NIM-CMPA group stand out. Among them, a significant reduction in the abundance of Bifidobacteriaceae and Bifidobacterium sequences with respect to controls was observed. Bifidobacterial species were also different, highlighting the lower abundance of Bifidobacterium breve sequences. Fecal calprotectin levels were found to be significantly elevated in relation to IgE mediated patients. Also, a higher excretion of IL-10 and a lower excretion of IL-1ra and platelet derived growth factor-BB was found in NIM-CMPA patients., Conclusions: The differential fecal parameters found in NIM-CMPA patients could be useful in the diagnosis of NIM food allergy to CM proteins., (© 2024 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.) more...
- Published
- 2024
- Full Text
- View/download PDF
26. The role of specialist nurses in detecting spasticity and related symptoms in multiple sclerosis.
- Author
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Artola M, Hernando A, Vidal O, Vidal N, Cuenca E, Horno R, Robles MÁ, Oriol C, Peralta S, Solana MAJ, Rubio M, Montero C, Lleixà M, Zabay C, Martin M, Leon I, Molinos C, Matamoros M, Mercadé L, Fornali O, Montero L, Saiz A, and Solà-Valls N more...
- Subjects
- Nurses, Activities of Daily Living, Quality of Life, Humans, Male, Female, Adolescent, Middle Aged, Spain, Adult, Aged, Cross-Sectional Studies, Multiple Sclerosis complications, Muscle Spasticity, Nurse Specialists
- Abstract
Background: Spasticity is a frequent symptom of multiple sclerosis (MS), which may negatively influence daily living activities (ADL)., Objectives: To (1) explore the feasibility to conduct a structured interview by specialist nurses about limitations in ADL; (2) determine the percentage of people with MS (PwMS) with limitations in ADL related to spasticity; (3) to assess the knowledge about spasticity and describe its clinical features., Design: Observational, cross-sectional, multicentre study in 16 MS units of Catalonia (Spain). Participants were recruited from the outpatient facility and day-care hospital between July 2018 and June 2019 and met the following criteria: (1) age 18 or older, (2) diagnosis of MS according to McDonald criteria 2010 and (3) no clinical relapse in previous 30 days., Methods: Specialist nurses conducted a structured interview divided in two parts: the assessment of (1) limitations in the ADL and (2) the presence of spasticity and associated symptoms. The usefulness of this intervention was requested. This study met the STROBE reporting guidelines checklist for observational studies., Results: Three hundred sixty eight pwMS (244 women) with a mean age of 46 years and a median Expanded Disability Status Scale score of 2.5 (range, 0-8.5) were included. 262 (71%) pwMS had limitations in the ADL, and spasticity was reported as the most limiting symptom in 59 (23%). As a result of the interview, spasticity was observed in 199 (76%) participants; 47 (24%) of them were unaware that they had spasticity and 102 (51%) would not have reported it spontaneously. The level of the interview satisfaction was high (90%)., Conclusions: Spasticity is a complex and limiting symptom in MS. The structured interview conducted by specialist nurses is feasible and has good acceptance., Patient Contribution: Specialist nurses can be proactive in MS clinical assessment, which may help to detect symptoms with negative impact on quality of life., (© 2022 John Wiley & Sons Ltd.) more...
- Published
- 2023
- Full Text
- View/download PDF
27. Model Corrected Blood Input Function to Compute Cerebral FDG Uptake Rates From Dynamic Total-Body PET Images of Rats in vivo .
- Author
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Massey JC, Seshadri V, Paul S, Mińczuk K, Molinos C, Li J, and Kundu BK
- Abstract
Recently, we developed a three-compartment dual-output model that incorporates spillover (SP) and partial volume (PV) corrections to simultaneously estimate the kinetic parameters and model-corrected blood input function (MCIF) from dynamic 2-[18F] fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) images of mouse heart in vivo . In this study, we further optimized this model and utilized the estimated MCIF to compute cerebral FDG uptake rates, K
i , from dynamic total-body FDG PET images of control Wistar-Kyoto (WKY) rats and compared to those derived from arterial blood sampling in vivo . Dynamic FDG PET scans of WKY rats ( n = 5), fasted for 6 h, were performed using the Albira Si Trimodal PET/SPECT/CT imager for 60 min. Arterial blood samples were collected for the entire imaging duration and then fitted to a seven-parameter function. The 60-min list mode PET data, corrected for attenuation, scatter, randoms, and decay, were reconstructed into 23 time bins. A 15-parameter dual-output model with SP and PV corrections was optimized with two cost functions to compute MCIF. A four-parameter compartment model was then used to compute cerebral Ki. The computed area under the curve (AUC) and Ki were compared to that derived from arterial blood samples. Experimental and computed AUCs were 1,893.53 ± 195.39 kBq min/cc and 1,792.65 ± 155.84 kBq min/cc, respectively ( p = 0.76). Bland-Altman analysis of experimental vs. computed Ki for 35 cerebral regions in WKY rats revealed a mean difference of 0.0029 min-1 (~13.5%). Direct (AUC) and indirect (Ki) comparisons of model computations with arterial blood sampling were performed in WKY rats. AUC and the downstream cerebral FDG uptake rates compared well with that obtained using arterial blood samples. Experimental vs. computed cerebral Ki for the four super regions including cerebellum, frontal cortex, hippocampus, and striatum indicated no significant differences., Competing Interests: CM was employed by company Bruker Biospin. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Massey, Seshadri, Paul, Mińczuk, Molinos, Li and Kundu.) more...- Published
- 2021
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28. Characterization of a preclinical PET insert in a 7 tesla MRI scanner: beyond NEMA testing.
- Author
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Gsell W, Molinos C, Correcher C, Belderbos S, Wouters J, Junge S, Heidenreich M, Velde GV, Rezaei A, Nuyts J, Cawthorne C, Cleeren F, Nannan L, Deroose CM, Himmelreich U, and Gonzalez AJ
- Subjects
- Animals, Equipment Design, Linear Models, Mice, Phantoms, Imaging, Rats, Signal-To-Noise Ratio, Magnetic Resonance Imaging instrumentation, Positron-Emission Tomography instrumentation
- Abstract
This study evaluates the performance of the Bruker positron emission tomograph (PET) insert combined with a BioSpec 70/30 USR magnetic resonance imaging (MRI) scanner using the manufacturer acceptance protocol and the NEMA NU 4-2008 for small animal PET. The PET insert is made of 3 rings of 8 monolithic LYSO crystals (50 × 50 × 10 mm
3 ) coupled to silicon photomultipliers (SiPM) arrays, conferring an axial and transaxial FOV of 15 cm and 8 cm. The MRI performance was evaluated with and without the insert for the following radiofrequency noise, magnetic field homogeneity and image quality. For the PET performance, we extended the NEMA protocol featuring system sensitivity, count rates, spatial resolution and image quality to homogeneity and accuracy for quantification using several MRI sequences (RARE, FLASH, EPI and UTE). The PET insert does not show any adverse effect on the MRI performances. The MR field homogeneity is well preserved (Diameter Spherical Volume, for 20 mm of 1.98 ± 4.78 without and -0.96 ± 5.16 Hz with the PET insert). The PET insert has no major effect on the radiofrequency field. The signal-to-noise ratio measurements also do not show major differences. Image ghosting is well within the manufacturer specifications (<2.5%) and no RF noise is visible. Maximum sensitivity of the PET insert is 11.0% at the center of the FOV even with simultaneous acquisition of EPI and RARE. PET MLEM resolution is 0.87 mm (FWHM) at 5 mm off-center of the FOV and 0.97 mm at 25 mm radial offset. The peaks for true/noise equivalent count rates are 410/240 and 628/486 kcps for the rat and mouse phantoms, and are reached at 30.34/22.85 and 27.94/22.58 MBq. PET image quality is minimally altered by the different MRI sequences. The Bruker PET insert shows no adverse effect on the MRI performance and demonstrated a high sensitivity, sub-millimeter resolution and good image quality even during simultaneous MRI acquisition. more...- Published
- 2020
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29. Low-Dose Imaging in a New Preclinical Total-Body PET/CT Scanner.
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Molinos C, Sasser T, Salmon P, Gsell W, Viertl D, Massey JC, Mińczuk K, Li J, Kundu BK, Berr S, Correcher C, Bahadur A, Attarwala AA, Stark S, Junge S, Himmelreich U, Prior JO, Laperre K, Van Wyk S, and Heidenreich M more...
- Abstract
Ionizing radiation constitutes a health risk to imaging scientists and study animals. Both PET and CT produce ionizing radiation. CT doses in pre-clinical in vivo imaging typically range from 50 to 1,000 mGy and biological effects in mice at this dose range have been previously described. [
18 F]FDG body doses in mice have been estimated to be in the range of 100 mGy for [18 F]FDG. Yearly, the average whole body doses due to handling of activity by PET technologists are reported to be 3-8 mSv. A preclinical PET/CT system is presented with design features which make it suitable for small animal low-dose imaging. The CT subsystem uses a X-source power that is optimized for small animal imaging. The system design incorporates a spatial beam shaper coupled with a highly sensitive flat-panel detector and very fast acquisition (<10 s) which allows for whole body scans with doses as low as 3 mGy. The mouse total-body PET subsystem uses a detector architecture based on continuous crystals, coupled to SiPM arrays and a readout based in rows and columns. The PET field of view is 150 mm axial and 80 mm transaxial. The high solid-angle coverage of the sample and the use of continuous crystals achieve a sensitivity of 9% (NEMA) that can be leveraged for use of low tracer doses and/or performing rapid scans. The low-dose imaging capabilities of the total-body PET subsystem were tested with NEMA phantoms, in tumor models, a mouse bone metabolism scan and a rat heart dynamic scan. The CT imaging capabilities were tested in mice and in a low contrast phantom. The PET low-dose phantom and animal experiments provide evidence that image quality suitable for preclinical PET studies is achieved. Furthermore, CT image contrast using low dose scan settings was suitable as a reference for PET scans. Total-body mouse PET/CT studies could be completed with total doses of <10 mGy. more...- Published
- 2019
- Full Text
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30. [Non-conventional fractionation in the irradiation of transitional cell tumors of the urinary bladder].
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Villar Rodriguez A, Martínez Cedrés JC, Fuentes Sánchez C, Espiñeíra Yanes M, Perez Suárez MD, Cabezón Pons MA, and Borque Molinos CM
- Subjects
- Dose Fractionation, Radiation, Humans, Carcinoma, Transitional Cell radiotherapy, Urinary Bladder Neoplasms radiotherapy
- Abstract
Objective: To analyze the potentials of non-conventional fractionated radiotherapy regimens for transitional cell tumors of the urinary bladder., Methods: The biological principles and clinical aspects taken into account in the design of non-conventional fractionated radiotherapy and the possibility of incorporating the foregoing to enhance the efficacy of the treatment protocols that are widely utilized are briefly analyzed., Results: Non-conventional fractionation enhances the results achieved with conventional radiotherapeutic regimens and should be included together with chemotherapy and cystectomy in the treatment of bladder cancer., Conclusions: Preservation of the bladder while maintaining or improving the cure rate continues to be the principal aim of treatment in cancer of the urinary bladder. The foregoing can be achieved with chemoradiotherapeutic regimens that include non-conventional fractionation of the radiation dose. A better understanding and knowledge of the factors that may have an influence on the therapeutic response and outcome can enhance patient selection for cystectomy. more...
- Published
- 1999
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