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3 results on '"Momoka Tsuneyoshi"'

1. Multiomics analysis to explore blood metabolite biomarkers in an Alzheimer’s Disease Neuroimaging Initiative cohort

Author

Takaki Oka, Yuki Matsuzawa, Momoka Tsuneyoshi, Yoshitaka Nakamura, Ken Aoshima, Hiroshi Tsugawa, and the Alzheimer’s Disease Metabolomics Consortium

Subjects
Medicine, Science
Abstract

Abstract Alzheimer's disease (AD) is a neurodegenerative disease that commonly causes dementia. Identifying biomarkers for the early detection of AD is an emerging need, as brain dysfunction begins two decades before the onset of clinical symptoms. To this end, we reanalyzed untargeted metabolomic mass spectrometry data from 905 patients enrolled in the AD Neuroimaging Initiative (ADNI) cohort using MS-DIAL, with 1,304,633 spectra of 39,108 unique biomolecules. Metabolic profiles of 93 hydrophilic metabolites were determined. Additionally, we integrated targeted lipidomic data (4873 samples from 1524 patients) to explore candidate biomarkers for predicting progressive mild cognitive impairment (pMCI) in patients diagnosed with AD within two years using the baseline metabolome. Patients with lower ergothioneine levels had a 12% higher rate of AD progression with the significance of P = 0.012 (Wald test). Furthermore, an increase in ganglioside (GM3) and decrease in plasmalogen lipids, many of which are associated with apolipoprotein E polymorphism, were confirmed in AD patients, and the higher levels of lysophosphatidylcholine (18:1) and GM3 d18:1/20:0 showed 19% and 17% higher rates of AD progression, respectively (Wald test: P = 3.9 × 10–8 and 4.3 × 10–7). Palmitoleamide, oleamide, diacylglycerols, and ether lipids were also identified as significantly altered metabolites at baseline in patients with pMCI. The integrated analysis of metabolites and genomics data showed that combining information on metabolites and genotypes enhances the predictive performance of AD progression, suggesting that metabolomics is essential to complement genomic data. In conclusion, the reanalysis of multiomics data provides new insights to detect early development of AD pathology and to partially understand metabolic changes in age-related onset of AD.

Published
2024
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2. Collaborative environmental DNA sampling from petal surfaces of flowering cherry Cerasus ×- yedoensis 'Somei-yoshino' across the Japanese archipelago

Author

Kazuharu Arakawa, Motomu Matsui, Shuichi Kawashima, Takeshi Kawashima, Wataru Nemoto, Momoka Tsuneyoshi, Keiichi Kanno, Akito Dobashi, Yukuto Sato, Yosuke Tanigawa, Takafumi Kataoka, Haruo Suzuki, Tazro Ohta, Kazutoshi Yoshitake, Suguru Nishijima, Satoshi Hiraoka, Yoichi Takenaka, Wataru Iwasaki, Y-h. Taguchi, Riu Yamashita, Natsuko O. Shinozaki, Tatsuhiko Hoshino, and Natsuki Suganuma

Subjects
geography, geography.geographical_feature_category, Prunus x yedoensis, fungi, Biology, medicine.disease_cause, chemistry.chemical_compound, chemistry, Pollen, Archipelago, Botany, medicine, Biological dispersal, Environmental DNA, Petal, Cultivar, DNA
Abstract

Recent studies have shown that environmental DNA is found almost everywhere. Flower petal surfaces are an attractive tissue to use for investigation of the dispersal of environmental DNA in nature as they are isolated from the external environment until the bud opens and only then can the petal surface accumulate environmental DNA. Here, we performed a crowdsourced experiment, the “Ohanami Project”, to obtain environmental DNA samples from petal surfaces of Cerasus × yedoensis ‘Somei-yoshino’ across the Japanese archipelago during spring 2015. C. × yedoensis is the most popular garden cherry species in Japan and clones of this cultivar bloom simultaneously every spring. Data collection spanned almost every prefecture and totaled 577 DNA samples from 149 collaborators. Preliminary amplicon-sequencing analysis showed the rapid attachment of environmental DNA onto the petal surfaces. Notably, we found DNA of other common plant species in samples obtained across a wide distribution; this DNA likely originated from pollen of the Japanese cedar. Our analysis supports our belief that petal surfaces after blossoming are a promising target to reveal the dynamics of environmental DNA in nature. The success of our experiment also shows that crowdsourced environmental DNA analyses have considerable value in ecological studies.

Published
2017
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3. Collaborative environmental DNA sampling from petal surfaces of flowering cherry Cerasus × yedoensis 'Somei-yoshino' across the Japanese archipelago

Author

Riu Yamashita, Shuichi Kawashima, Motomu Matsui, Momoka Tsuneyoshi, Keiichi Kanno, Wataru Nemoto, Tazro Ohta, Tatsuhiko Hoshino, Yosuke Tanigawa, Akito Dobashi, Haruo Suzuki, Takeshi Kawashima, Satoshi Hiraoka, Yukuto Sato, Takafumi Kataoka, Yoichi Takenaka, Wataru Iwasaki, Y-h. Taguchi, Natsuko O. Shinozaki, Natsuki Suganuma, Kazutoshi Yoshitake, Suguru Nishijima, and Kazuharu Arakawa

Subjects
0301 basic medicine, Chloroplasts, Prunus x yedoensis, DNA, Plant, Plant Science, Flowers, Biology, Environment, medicine.disease_cause, Cyanobacteria, 03 medical and health sciences, chemistry.chemical_compound, Japan, Pollen, Botany, Proteobacteria, medicine, Environmental DNA, Cultivar, geography, geography.geographical_feature_category, fungi, DNA, Sequence Analysis, DNA, 030104 developmental biology, chemistry, Archipelago, Biological dispersal, Petal, Prunus, Sequence Alignment
Abstract

Recent studies have shown that environmental DNA is found almost everywhere. Flower petal surfaces are an attractive tissue to use for investigation of the dispersal of environmental DNA in nature as they are isolated from the external environment until the bud opens and only then can the petal surface accumulate environmental DNA. Here, we performed a crowdsourced experiment, the “Ohanami Project”, to obtain environmental DNA samples from petal surfaces of Cerasus × yedoensis ‘Somei-yoshino’ across the Japanese archipelago during spring 2015. C. × yedoensis is the most popular garden cherry species in Japan and clones of this cultivar bloom simultaneously every spring. Data collection spanned almost every prefecture and totaled 577 DNA samples from 149 collaborators. Preliminary amplicon-sequencing analysis showed the rapid attachment of environmental DNA onto the petal surfaces. Notably, we found DNA of other common plant species in samples obtained from a wide distribution; this DNA likely originated from the pollen of the Japanese cedar. Our analysis supports our belief that petal surfaces after blossoming are a promising target to reveal the dynamics of environmental DNA in nature. The success of our experiment also shows that crowdsourced environmental DNA analyses have considerable value in ecological studies.

Published
2017

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