1. Regulatory effects of berberine on microRNome in Cancer and other conditions
- Author
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Amir Abbas Momtazi-Borojeni, Arrigo F G Cicero, Badrieh Fazeli, Amirhossein Sahebkar, Matteo Pirro, Seyed Hasan Ayati, Ayati, Sh, Fazeli, B, Momtazi-Borojeni, Aa, Cicero, Afg, Pirro, M, and Sahebkar, A.
- Subjects
0301 basic medicine ,Untranslated region ,Berberine ,Apoptosis ,Pharmacology ,Biology ,Diabete ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Neoplasms ,microRNA ,medicine ,Animals ,Humans ,Cell Proliferation ,Regulation of gene expression ,Cell growth ,Diabetes ,RNA ,Cancer ,MicroRNA ,Hematology ,medicine.disease ,Oncology ,Gene Expression Regulation ,MicroRNAs ,Geriatrics and Gerontology ,RNA silencing ,030104 developmental biology ,chemistry ,030220 oncology & carcinogenesis - Abstract
Berberine (BBR) is an isoquinoline alkaloid found in different plant families such as Berberidaceae, Ranunculaceae, and Papaveraceae. BBR is well-known for its anti-inflammatory, lipid-modifying, anticancer, anti-diabetic, antibacterial, antiparasitic and fungicide activities. Multiple pharmacological actions of BBR stem from different molecular targets of this phytochemical. MicroRNAs (miRs) are single-stranded, evolutionary conserved, small non-coding RNA molecules with a length of 19-23 nucleotides that are involved in RNA silencing and post-transcriptional regulation of gene expression through binding to the 3'-untranslated region (3'UTR) of target mRNA. MiRs emerged as important regulatory elements in almost all biological processes like cell proliferation, apoptosis, differentiation and organogenesis, and numerous human diseases such as cancer and diabetes. BBR was shown to regulate the expression of miRs in several diseases. Here, we reviewed the target miRs of BBR and the relevance of their modulation for the potential treatment of serious human diseases like multiple myeloma, hepatocellular carcinoma, colorectal cancer, gastric cancer, ovarian cancer and glioblastoma. The role of miR regulation in the putative anti-diabetic effects of BBR is discussed, as well.
- Published
- 2017