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20. Chemical intervention of influenza virus mRNA nuclear export

Author

Esparza, Matthew, primary, Mor, Amir, additional, Niederstrasser, Hanspeter, additional, White, Kris, additional, White, Alexander, additional, Zhang, Ke, additional, Gao, Shengyan, additional, Wang, Juan, additional, Liang, Jue, additional, Sho, Sei, additional, Sakthivel, Ramanavelan, additional, Sathe, Adwait A., additional, Xing, Chao, additional, Muñoz-Moreno, Raquel, additional, Shay, Jerry W., additional, García-Sastre, Adolfo, additional, Ready, Joseph, additional, Posner, Bruce, additional, and Fontoura, Beatriz M. A., additional

Published
2020
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29. Influenza virus mRNA trafficking through host nuclear speckles

Author

Mor, Amir, primary, White, Alexander, additional, Zhang, Ke, additional, Thompson, Matthew, additional, Esparza, Matthew, additional, Muñoz-Moreno, Raquel, additional, Koide, Kazunori, additional, Lynch, Kristen W., additional, García-Sastre, Adolfo, additional, and Fontoura, Beatriz M. A., additional

Published
2016
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34. Fetal proximal humeral epiphysis as an indicator of term gestation in different ethnic groups.

Author

Garg, Deepika, Homel, Peter, Hirachan, Tinu, Mor, Amir, Patel, Kalpesh, Karakash, Scarlett, and Haberman, Shoshana

Subjects
PREGNANCY, FETAL development, EPIPHYSIS, ETHNIC groups, THREE-dimensional imaging, FETAL ultrasonic imaging, GESTATIONAL age, HUMERUS, SKELETAL maturity, CROSS-sectional method
Abstract

Objectives: Accurate pregnancy dating is critical for appropriate clinical management. Our aim was to determine the time of appearance of proximal humeral epiphysis (PHE), consistency of its appearance among ethnic groups and whether 3D imaging helps with its visualization.Methods: A cross-sectional study was done on 360 patients with 563 scans in different ethnic groups between August 2013 and July 2015. Inclusion criteria were singleton pregnancies (34-40+  weeks of gestation), well dated by <20 weeks sonogram.Results: PHE was not seen at 34 (n = 44) or 35 weeks (n = 36) and was present at gestational ages 36 (n = 3), 37 (n = 126), 38 (n = 96), 39 (n = 100) and 40 weeks (n = 28) in 2%, 12%, 51%, 75% and 100%, respectively. PHE was seen in 20 of 50 (60%) African-Americans, 22 of 61 (64%) south Asians, 41 of 72 (57%) Caucasians, 45 of 86 (48%) Hispanics and 41 of 80 (49%) Asians.Conclusion: Appearance of PHE did increase with gestational age, prior to 40 weeks, it was not uniformly present and was seen as early as 36 weeks independent of ethnic group. [ABSTRACT FROM AUTHOR]

Published
2017
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41. The life of an mRNA in space and time

Author

Ben-Ari, Ya'ara, primary, Brody, Yehuda, additional, Kinor, Noa, additional, Mor, Amir, additional, Tsukamoto, Toshiro, additional, Spector, David L., additional, Singer, Robert H., additional, and Shav-Tal, Yaron, additional

Published
2010
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44. Differential effect of high pressure on NMDA receptor currents in Xenopus laevis oocytes.

Author

Mor, Amir, Levy, Shiri, Hollmann, Michael, and Grossman, Yoram

Abstract

The article discusses a study which examined the N-methyl-D-aspartate receptor (NMDAR) component alone without the contribution of the central nervous system (CNS) network. Mammalian cRNA of the most common hippocampal NMDAR compositions NR1-1a/NR2A and NR1-1b/NR2A were injected into Xenopus laevis oocytes. According to the researchers, increased NMDAR response, in addition to other mechanisms, plays in important role in high pressure neurological syndrome (HPNS).

Published
2008

45. Fetal proximal humeral epiphysis as an indicator of term gestation in different ethnic groups.

Author

Garg, Deepika, Homel, Peter, Hirachan, Tinu, Mor, Amir, Patel, Kalpesh, Karakash, Scarlett, and Haberman, Shoshana

Subjects
*PREGNANCY, *FETAL development, *EPIPHYSIS, *ETHNIC groups, *THREE-dimensional imaging, *FETAL ultrasonic imaging, *GESTATIONAL age, *HUMERUS, *SKELETAL maturity, *CROSS-sectional method
Abstract

Objectives: Accurate pregnancy dating is critical for appropriate clinical management. Our aim was to determine the time of appearance of proximal humeral epiphysis (PHE), consistency of its appearance among ethnic groups and whether 3D imaging helps with its visualization.Methods: A cross-sectional study was done on 360 patients with 563 scans in different ethnic groups between August 2013 and July 2015. Inclusion criteria were singleton pregnancies (34-40+  weeks of gestation), well dated by <20 weeks sonogram.Results: PHE was not seen at 34 (n = 44) or 35 weeks (n = 36) and was present at gestational ages 36 (n = 3), 37 (n = 126), 38 (n = 96), 39 (n = 100) and 40 weeks (n = 28) in 2%, 12%, 51%, 75% and 100%, respectively. PHE was seen in 20 of 50 (60%) African-Americans, 22 of 61 (64%) south Asians, 41 of 72 (57%) Caucasians, 45 of 86 (48%) Hispanics and 41 of 80 (49%) Asians.Conclusion: Appearance of PHE did increase with gestational age, prior to 40 weeks, it was not uniformly present and was seen as early as 36 weeks independent of ethnic group. [ABSTRACT FROM AUTHOR]

Published
2017
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46. Fetal proximal humeral epiphysis as an indicator of term gestation in different ethnic groups .

Author

Garg D, Homel P, Hirachan T, Mor A, Patel K, Karakash S, and Haberman S

Subjects
Cross-Sectional Studies, Epiphyses diagnostic imaging, Female, Humans, Pregnancy, Age Determination by Skeleton methods, Gestational Age, Humerus diagnostic imaging, Ultrasonography, Prenatal methods
Abstract

Objectives: Accurate pregnancy dating is critical for appropriate clinical management. Our aim was to determine the time of appearance of proximal humeral epiphysis (PHE), consistency of its appearance among ethnic groups and whether 3D imaging helps with its visualization., Methods: A cross-sectional study was done on 360 patients with 563 scans in different ethnic groups between August 2013 and July 2015. Inclusion criteria were singleton pregnancies (34-40+  weeks of gestation), well dated by <20 weeks sonogram., Results: PHE was not seen at 34 (n = 44) or 35 weeks (n = 36) and was present at gestational ages 36 (n = 3), 37 (n = 126), 38 (n = 96), 39 (n = 100) and 40 weeks (n = 28) in 2%, 12%, 51%, 75% and 100%, respectively. PHE was seen in 20 of 50 (60%) African-Americans, 22 of 61 (64%) south Asians, 41 of 72 (57%) Caucasians, 45 of 86 (48%) Hispanics and 41 of 80 (49%) Asians., Conclusion: Appearance of PHE did increase with gestational age, prior to 40 weeks, it was not uniformly present and was seen as early as 36 weeks independent of ethnic group.

Published
2017
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48. Dynamics and kinetics of nucleo-cytoplasmic mRNA export.

Author

Mor A and Shav-Tal Y

Subjects
Active Transport, Cell Nucleus, Animals, Humans, Kinetics, Models, Biological, Nuclear Envelope metabolism, Nuclear Pore metabolism, Cell Nucleus metabolism, RNA, Messenger metabolism
Abstract

Activation of the gene expression pathway in eukaryotic cells results in the nuclear transcription of mRNA molecules, many of which are destined for translation into protein by cytoplasmic ribosomes. mRNA transcripts are exported from the nucleus to the cytoplasm via passage through nuclear pore complexes (NPCs), ∼125 MDa supramolecular complexes set in the double-membraned nuclear envelope. Understanding the kinetics of mRNA translocation, from the point of transcription through export, localization, translation, and degradation, is of fundamental interest since gene expression is regulated at all the different levels of this pathway. In this review, we delineate the steps taken by an mRNA molecule in transit to the nuclear envelope and during mRNA export, with specific focus on the dynamic aspects of nucleo-cytoplasmic mRNA transport as revealed by electron microscopy and live-cell imaging., (Copyright © 2010 John Wiley & Sons, Ltd.)

Published
2010
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